Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	tRNA-4-demethylwyosine synthase activity	TYW1B TYW1	6.65e-06	2	52	2	GO:0102521
GeneOntologyMolecularFunction	G protein-coupled acetylcholine receptor activity	CHRM1 CHRM5	1.39e-04	7	52	2	GO:0016907
GeneOntologyMolecularFunction	oxo-acid-lyase activity	TYW1B TYW1	1.39e-04	7	52	2	GO:0016833
GeneOntologyMolecularFunction	G protein-coupled neurotransmitter receptor activity	CHRM1 CHRM5	5.09e-04	13	52	2	GO:0099528
GeneOntologyMolecularFunction	FMN binding	TYW1B TYW1	7.80e-04	16	52	2	GO:0010181
GeneOntologyMolecularFunction	SUMO ligase activity	RANBP2 RGPD1	1.23e-03	20	52	2	GO:0061665
GeneOntologyMolecularFunction	G protein-coupled serotonin receptor activity	CHRM1 CHRM5	1.49e-03	22	52	2	GO:0004993
GeneOntologyMolecularFunction	acetylcholine receptor activity	CHRM1 CHRM5	1.62e-03	23	52	2	GO:0015464
GeneOntologyCellularComponent	cytoplasmic periphery of the nuclear pore complex	RANBP2 RGPD1	1.56e-04	8	50	2	GO:1990723
GeneOntologyCellularComponent	nuclear pore cytoplasmic filaments	RANBP2 RGPD1	2.49e-04	10	50	2	GO:0044614
GeneOntologyCellularComponent	annulate lamellae	RANBP2 RGPD1	5.01e-04	14	50	2	GO:0005642
GeneOntologyCellularComponent	microtubule associated complex	SPTBN5 DYNC2I2 DNAH10 KIF17	5.92e-04	161	50	4	GO:0005875
GeneOntologyCellularComponent	nuclear pore nuclear basket	RANBP2 RGPD1	8.37e-04	18	50	2	GO:0044615
GeneOntologyCellularComponent	plasma membrane bounded cell projection cytoplasm	SPTBN5 DST DYNC2I2 DNAH10 KIF17	9.42e-04	317	50	5	GO:0032838
GeneOntologyCellularComponent	ciliary transition zone	SPTBN5 KIF17 BBS9	9.63e-04	81	50	3	GO:0035869
GeneOntologyCellularComponent	nuclear inclusion body	RANBP2 RGPD1	1.04e-03	20	50	2	GO:0042405
GeneOntologyCellularComponent	SUMO ligase complex	RANBP2 RGPD1	1.14e-03	21	50	2	GO:0106068
GeneOntologyCellularComponent	axoneme	SPTBN5 DYNC2I2 DNAH10 KIF17	1.51e-03	207	50	4	GO:0005930
GeneOntologyCellularComponent	ciliary plasm	SPTBN5 DYNC2I2 DNAH10 KIF17	1.53e-03	208	50	4	GO:0097014
GeneOntologyCellularComponent	cytoplasmic region	SPTBN5 DST DYNC2I2 DNAH10 KIF17	1.65e-03	360	50	5	GO:0099568
GeneOntologyCellularComponent	perinuclear endoplasmic reticulum	DST TRIM13	2.18e-03	29	50	2	GO:0097038
GeneOntologyCellularComponent	recycling endosome membrane	SLC9A5 CLCN4 VPS13B	2.44e-03	112	50	3	GO:0055038
Domain	tRNA_wybutosine-synth	TYW1B TYW1	7.31e-06	2	51	2	IPR013917
Domain	Wyosine_form	TYW1B TYW1	7.31e-06	2	51	2	PF08608
Domain	Musac_Ach_rcpt	CHRM1 CHRM5	7.27e-05	5	51	2	IPR000995
Domain	FLAVODOXIN_LIKE	TYW1B TYW1	2.03e-04	8	51	2	PS50902
Domain	Flavodoxin/NO_synth	TYW1B TYW1	2.03e-04	8	51	2	IPR008254
Domain	Flavdoxin-like	TYW1B TYW1	2.03e-04	8	51	2	IPR001094
Domain	Flavodoxin_1	TYW1B TYW1	2.03e-04	8	51	2	PF00258
Domain	rSAM	TYW1B TYW1	2.60e-04	9	51	2	IPR007197
Domain	Radical_SAM	TYW1B TYW1	2.60e-04	9	51	2	PF04055
Domain	MIT	RPS6KL1 RPS6KC1	3.24e-04	10	51	2	SM00745
Domain	Flavoprotein-like_dom	TYW1B TYW1	3.24e-04	10	51	2	IPR029039
Domain	MIT	RPS6KL1 RPS6KC1	3.24e-04	10	51	2	PF04212
Domain	-	TYW1B TYW1	3.24e-04	10	51	2	3.40.50.360
Domain	Ran_BP1	RANBP2 RGPD1	4.74e-04	12	51	2	PF00638
Domain	RANBD1	RANBP2 RGPD1	4.74e-04	12	51	2	PS50196
Domain	-	RPS6KL1 RPS6KC1	5.59e-04	13	51	2	1.20.58.280
Domain	RanBD	RANBP2 RGPD1	5.59e-04	13	51	2	SM00160
Domain	Ran_bind_dom	RANBP2 RGPD1	5.59e-04	13	51	2	IPR000156
Domain	MIT	RPS6KL1 RPS6KC1	6.51e-04	14	51	2	IPR007330
Domain	TPR_REGION	RANBP2 DNAH10 CDC16 RGPD1	1.06e-03	165	51	4	PS50293
Domain	TPR	RANBP2 DNAH10 CDC16 RGPD1	1.06e-03	165	51	4	PS50005
Domain	Actinin_actin-bd_CS	SPTBN5 DST	1.78e-03	23	51	2	IPR001589
Domain	Spectrin	SPTBN5 DST	1.78e-03	23	51	2	PF00435
Domain	ACTININ_2	SPTBN5 DST	1.78e-03	23	51	2	PS00020
Domain	ACTININ_1	SPTBN5 DST	1.78e-03	23	51	2	PS00019
Domain	TPR_1	RANBP2 CDC16 RGPD1	1.91e-03	90	51	3	PF00515
Domain	TPR_1	RANBP2 CDC16 RGPD1	1.91e-03	90	51	3	IPR001440
Domain	ARM-type_fold	PI4KA HECTD1 LYST STAG3 GPRASP2	2.27e-03	339	51	5	IPR016024
Domain	Spectrin_repeat	SPTBN5 DST	2.83e-03	29	51	2	IPR002017
Domain	Spectrin/alpha-actinin	SPTBN5 DST	3.44e-03	32	51	2	IPR018159
Domain	SPEC	SPTBN5 DST	3.44e-03	32	51	2	SM00150
Domain	GPS	ADGRF5 PKD1L2	3.88e-03	34	51	2	SM00303
Domain	GPS	ADGRF5 PKD1L2	4.11e-03	35	51	2	PF01825
Domain	GPS	ADGRF5 PKD1L2	4.34e-03	36	51	2	PS50221
Domain	GPS	ADGRF5 PKD1L2	4.58e-03	37	51	2	IPR000203
Domain	TPR	RANBP2 CDC16 RGPD1	5.26e-03	129	51	3	SM00028
Domain	G_PROTEIN_RECEP_F2_1	GPR157 ADGRF5	5.34e-03	40	51	2	PS00649
Domain	GPCR_2_extracellular_dom	GPR157 ADGRF5	5.34e-03	40	51	2	IPR001879
Domain	G_PROTEIN_RECEP_F2_3	GPR157 ADGRF5	5.34e-03	40	51	2	PS50227
Domain	WD40	DYNC2I2 LYST PHIP WDR72	5.42e-03	259	51	4	PF00400
Domain	TPR_repeat	RANBP2 CDC16 RGPD1	5.73e-03	133	51	3	IPR019734
Domain	-	TYW1B TYW1	5.87e-03	42	51	2	3.20.20.70
Domain	WD40	DYNC2I2 LYST PHIP WDR72	6.11e-03	268	51	4	SM00320
Domain	Aldolase_TIM	TYW1B TYW1	6.43e-03	44	51	2	IPR013785
Domain	WD40_repeat	DYNC2I2 LYST PHIP WDR72	6.43e-03	272	51	4	IPR001680
Domain	WD_REPEATS_1	DYNC2I2 LYST PHIP WDR72	6.93e-03	278	51	4	PS00678
Domain	WD_REPEATS_2	DYNC2I2 LYST PHIP WDR72	7.02e-03	279	51	4	PS50082
Domain	WD_REPEATS_REGION	DYNC2I2 LYST PHIP WDR72	7.02e-03	279	51	4	PS50294
Domain	TPR-contain_dom	RANBP2 CDC16 RGPD1	7.98e-03	150	51	3	IPR013026
Domain	G_PROTEIN_RECEP_F2_2	GPR157 ADGRF5	8.24e-03	50	51	2	PS00650
Domain	7tm_2	GPR157 ADGRF5	8.24e-03	50	51	2	PF00002
Domain	WD40_repeat_dom	DYNC2I2 LYST PHIP WDR72	8.71e-03	297	51	4	IPR017986
Pathway	REACTOME_MUSCARINIC_ACETYLCHOLINE_RECEPTORS	CHRM1 CHRM5	7.04e-05	5	38	2	M27300
Pathway	REACTOME_MUSCARINIC_ACETYLCHOLINE_RECEPTORS	CHRM1 CHRM5	7.04e-05	5	38	2	MM15006
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	DST TYW1B PI4KA TYW1 TRIM13 LYST VPS13B RPS6KC1	9.20e-07	504	53	8	34432599
Pubmed	Diminished antigen-specific IgG1 and interleukin-6 production and acetylcholinesterase expression in combined M1 and M5 muscarinic acetylcholine receptor knockout mice.	CHRM1 CHRM5	2.28e-06	2	53	2	17586055
Pubmed	Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs.	TYW1B TYW1	2.28e-06	2	53	2	16162496
Pubmed	The presence of m1 to m5 receptors in human sclera: evidence of the sclera as a potential site of action for muscarinic receptor antagonists.	CHRM1 CHRM5	2.28e-06	2	53	2	16877267
Pubmed	Analysis of CD8+ T cell-mediated anti-viral responses in mice with targeted deletions of the M1 or M5 muscarinic cholinergic receptors.	CHRM1 CHRM5	2.28e-06	2	53	2	17286988
Pubmed	Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes.	CHRM1 CHRM5	6.83e-06	3	53	2	1905013
Pubmed	Transcriptional regulation of the 230-kDa bullous pemphigoid antigen gene expression by interferon regulatory factor 1 and interferon regulatory factor 2 in normal human epidermal keratinocytes.	DST IRF1	6.83e-06	3	53	2	15560761
Pubmed	Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice.	CHRM1 CHRM5	6.83e-06	3	53	2	16956767
Pubmed	M1 receptors mediate cholinergic modulation of excitability in neocortical pyramidal neurons.	CHRM1 CHRM5	6.83e-06	3	53	2	19657040
Pubmed	Muscarinic cholinergic receptor (M2) plays a crucial role in the development of myopia in mice.	CHRM1 CHRM5	6.83e-06	3	53	2	23649821
Pubmed	M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice.	CHRM1 CHRM5	6.83e-06	3	53	2	15146045
Pubmed	Cholinergically stimulated gastric acid secretion is mediated by M(3) and M(5) but not M(1) muscarinic acetylcholine receptors in mice.	CHRM1 CHRM5	6.83e-06	3	53	2	15691866
Pubmed	Role of M1, M3, and M5 muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice.	CHRM1 CHRM5	6.83e-06	3	53	2	21335473
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	DST PI4KA CDC16 MARCHF6 PKD1L2 HECTD1	9.57e-06	322	53	6	26514267
Pubmed	Ciliary activity in the oviduct of cycling, pregnant, and muscarinic receptor knockout mice.	CHRM1 CHRM5	1.36e-05	4	53	2	22302687
Pubmed	Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway.	CHRM1 CHRM5	1.36e-05	4	53	2	8063729
Pubmed	Identification and characterization of muscarinic acetylcholine receptor subtypes expressed in human skin melanocytes.	CHRM1 CHRM5	1.36e-05	4	53	2	11855742
Pubmed	Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis.	TYW1B TYW1	1.36e-05	4	53	2	17150819
Pubmed	Differential regulation of primary afferent input to spinal cord by muscarinic receptor subtypes delineated using knockout mice.	CHRM1 CHRM5	2.27e-05	5	53	2	24695732
Pubmed	Dynamic control of glutamatergic synaptic input in the spinal cord by muscarinic receptor subtypes defined using knockout mice.	CHRM1 CHRM5	2.27e-05	5	53	2	20940295
Pubmed	Muscarinic receptors in the prenatal mouse embryo. Comparison of M35-immunohistochemistry with [3H]quinuclidinyl benzylate autoradiography.	CHRM1 CHRM5	2.27e-05	5	53	2	7648406
Pubmed	Muscarinic acetylcholine receptor subtype 4 is essential for cholinergic stimulation of duodenal bicarbonate secretion in mice - relationship to D cell/somatostatin.	CHRM1 CHRM5	2.27e-05	5	53	2	26084221
Pubmed	Roles of M2 and M4 muscarinic receptors in regulating acetylcholine release from myenteric neurons of mouse ileum.	CHRM1 CHRM5	2.27e-05	5	53	2	15574798
Pubmed	Acetylcholine modulates cortical synaptic transmission via different muscarinic receptors, as studied with receptor knockout mice.	CHRM1 CHRM5	2.27e-05	5	53	2	15919709
Pubmed	Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system.	CHRM1 CHRM5	2.27e-05	5	53	2	12675128
Pubmed	Regulation of CD8+ cytolytic T lymphocyte differentiation by a cholinergic pathway.	CHRM1 CHRM5	2.27e-05	5	53	2	15913791
Pubmed	Expression of multiple subtypes of muscarinic receptors and cellular distribution in the human heart.	CHRM1 CHRM5	2.27e-05	5	53	2	11306684
Pubmed	Muscarinic acetylcholine receptor subtypes: localization and structure/function.	CHRM1 CHRM5	2.27e-05	5	53	2	8248499
Pubmed	The M1 muscarinic acetylcholine receptor subtype is important for retinal neuron survival in aging mice.	CHRM1 CHRM5	2.27e-05	5	53	2	30914695
Pubmed	STAG3, a novel gene encoding a protein involved in meiotic chromosome pairing and location of STAG3-related genes flanking the Williams-Beuren syndrome deletion.	STAG3L1 STAG3	2.27e-05	5	53	2	10698974
Pubmed	Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice.	CHRM1 CHRM5	2.27e-05	5	53	2	12151512
Pubmed	Muscarinic receptors 2 and 5 regulate bitter response of urethral brush cells via negative feedback.	CHRM1 CHRM5	2.27e-05	5	53	2	29401598
Pubmed	Quantitative analysis of binding parameters of [3H]N-methylscopolamine in central nervous system of muscarinic acetylcholine receptor knockout mice.	CHRM1 CHRM5	2.27e-05	5	53	2	15661360
Pubmed	Muscarinic receptor subtypes in cilia-driven transport and airway epithelial development.	CHRM1 CHRM5	2.27e-05	5	53	2	19213795
Pubmed	The role of muscarinic receptor subtypes in acetylcholine release from urinary bladder obtained from muscarinic receptor knockout mouse.	CHRM1 CHRM5	2.27e-05	5	53	2	18755247
Pubmed	Muscarinic signaling in the cochlea: presynaptic and postsynaptic effects on efferent feedback and afferent excitability.	CHRM1 CHRM5	2.27e-05	5	53	2	20463237
Pubmed	Distinct muscarinic acetylcholine receptor subtypes contribute to stability and growth, but not compensatory plasticity, of neuromuscular synapses.	CHRM1 CHRM5	2.27e-05	5	53	2	19940190
Pubmed	Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling.	CHRM1 CHRM5	3.40e-05	6	53	2	31914675
Pubmed	The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7.	CHRM1 CHRM5	3.40e-05	6	53	2	19182865
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	RANBP2 DST RGPD1 GEMIN4 CHD6 GPRASP2	4.14e-05	418	53	6	34709266
Pubmed	Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.	RANBP2 RGPD1	4.76e-05	7	53	2	30944974
Pubmed	Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.	RANBP2 RGPD1	4.76e-05	7	53	2	38838144
Pubmed	Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.	RANBP2 RGPD1	4.76e-05	7	53	2	21205196
Pubmed	Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.	RANBP2 RGPD1	4.76e-05	7	53	2	18949001
Pubmed	Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.	RANBP2 RGPD1	4.76e-05	7	53	2	25187515
Pubmed	Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.	RANBP2 RGPD1	4.76e-05	7	53	2	9037092
Pubmed	Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.	RANBP2 RGPD1	4.76e-05	7	53	2	23536549
Pubmed	Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.	RANBP2 RGPD1	4.76e-05	7	53	2	8603673
Pubmed	Retina-specifically expressed novel subtypes of bovine cyclophilin.	RANBP2 RGPD1	4.76e-05	7	53	2	7559465
Pubmed	Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).	RANBP2 RGPD1	4.76e-05	7	53	2	26632511
Pubmed	Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.	RANBP2 RGPD1	4.76e-05	7	53	2	17372272
Pubmed	A parasympathetic neurotransmitter induces myoepithelial cell differentiation during salivary gland development.	CHRM1 CHRM5	4.76e-05	7	53	2	35427599
Pubmed	Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.	RANBP2 RGPD1	4.76e-05	7	53	2	24403063
Pubmed	Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.	RANBP2 RGPD1	4.76e-05	7	53	2	23818861
Pubmed	Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.	RANBP2 RGPD1	4.76e-05	7	53	2	38657106
Pubmed	Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.	RANBP2 RGPD1	4.76e-05	7	53	2	11353387
Pubmed	Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.	RANBP2 RGPD1	4.76e-05	7	53	2	12191015
Pubmed	Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	RANBP2 RGPD1	4.76e-05	7	53	2	22821000
Pubmed	Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.	RANBP2 RGPD1	4.76e-05	7	53	2	20682751
Pubmed	The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.	RANBP2 RGPD1	6.34e-05	8	53	2	22262462
Pubmed	The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.	RANBP2 RGPD1	6.34e-05	8	53	2	21670213
Pubmed	Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.	RANBP2 RGPD1	6.34e-05	8	53	2	28745977
Pubmed	Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.	RANBP2 RGPD1	6.34e-05	8	53	2	27412403
Pubmed	TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages.	IRF1 LYST	6.34e-05	8	53	2	35864246
Pubmed	Mice lacking Ran binding protein 1 are viable and show male infertility.	RANBP2 RGPD1	6.34e-05	8	53	2	21310149
Pubmed	The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.	RANBP2 RGPD1	8.15e-05	9	53	2	9733766
Pubmed	Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.	RANBP2 RGPD1	8.15e-05	9	53	2	28100513
Pubmed	Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.	RANBP2 RGPD1	8.15e-05	9	53	2	18394993
Pubmed	Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.	RANBP2 RGPD1	8.15e-05	9	53	2	28877029
Pubmed	The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.	RANBP2 RGPD1	8.15e-05	9	53	2	11553612
Pubmed	Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.	RANBP2 RGPD1	8.15e-05	9	53	2	17887960
Pubmed	The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.	RANBP2 RGPD1	8.15e-05	9	53	2	10601307
Pubmed	The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.	RANBP2 RGPD1	1.02e-04	10	53	2	27160050
Pubmed	Parkin ubiquitinates and promotes the degradation of RanBP2.	RANBP2 RGPD1	1.02e-04	10	53	2	16332688
Pubmed	Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines.	CHRM1 CHRM5	1.02e-04	10	53	2	10336173
Pubmed	Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.	RANBP2 RGPD1	1.02e-04	10	53	2	8857542
Pubmed	Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.	RANBP2 RGPD1	1.02e-04	10	53	2	21859863
Pubmed	An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.	RANBP2 RGPD1	1.24e-04	11	53	2	35771867
Pubmed	RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.	RANBP2 RGPD1	1.24e-04	11	53	2	17069463
Pubmed	T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.	RANBP2 RGPD1	1.24e-04	11	53	2	34110283
Pubmed	The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3.	MAP3K10 KIF17	1.24e-04	11	53	2	9427749
Pubmed	Genome-wide CRISPR-cas9 knockout screening identifies GRB7 as a driver for MEK inhibitor resistance in KRAS mutant colon cancer.	RANBP2 GEMIN4 GNL3	1.24e-04	63	53	3	34718347
Pubmed	NCOA2 promotes lytic reactivation of Kaposi's sarcoma-associated herpesvirus by enhancing the expression of the master switch protein RTA.	PI4KA GEMIN4 HECTD1	1.70e-04	70	53	3	31751430
Pubmed	Multiple loci influencing hippocampal degeneration identified by genome scan.	CHD6 VPS13B	1.76e-04	13	53	2	22745009
Pubmed	Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.	RANBP2 RGPD1	1.76e-04	13	53	2	31427429
Pubmed	Identification of a novel family of G protein-coupled receptor associated sorting proteins.	CHRM1 GPRASP2	2.05e-04	14	53	2	15086532
Pubmed	The BBSome controls IFT assembly and turnaround in cilia.	KIF17 BBS9	2.36e-04	15	53	2	22922713
Pubmed	Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.	RANBP2 RGPD1	2.36e-04	15	53	2	14697343
Pubmed	Human transcription factor protein interaction networks.	KLF12 DST DNAH10 RGPD1 IRF1 TWNK CHD6 ZNF471 GNL3	2.82e-04	1429	53	9	35140242
Pubmed	Mapping of five subtype genes for muscarinic acetylcholine receptor to mouse chromosomes.	CHRM1 CHRM5	3.05e-04	17	53	2	10549128
Pubmed	The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.	RANBP2 RGPD1 PHIP	3.13e-04	86	53	3	37253089
Pubmed	A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein.	KLF12 IRF1	3.43e-04	18	53	2	20599664
Pubmed	No evidence for association between 19 cholinergic genes and bipolar disorder.	CHRM1 CHRM5	3.83e-04	19	53	2	17373692
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	SPTBN5 DST PI4KA GEMIN4 TWNK TRIM13 PHIP GNL3 VPS13B	3.94e-04	1496	53	9	32877691
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	RANBP2 DST GEMIN4 HECTD1 PHIP GNL3	4.65e-04	653	53	6	22586326
Pubmed	A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP).	CHRM1 CHRM5	4.70e-04	21	53	2	15452121
Pubmed	Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.	DNAH10 GNL3	4.70e-04	21	53	2	22479202
Pubmed	Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.	RANBP2 RGPD1	5.16e-04	22	53	2	27717094
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	RANBP2 PI4KA CHD6 PHIP RPS6KC1	7.79e-04	475	53	5	31040226
Pubmed	The protein kinase complement of the human genome.	RPS6KL1 RPS6KC1	8.40e-04	28	53	2	12471243
GeneFamily	Cholinergic receptors muscarinic	CHRM1 CHRM5	4.06e-05	5	37	2	180
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RANBP2 CDC16 RGPD1	1.66e-03	115	37	3	769
GeneFamily	WD repeat domain containing	DYNC2I2 LYST PHIP WDR72	1.95e-03	262	37	4	362
ToppCell	367C-Myeloid-Dendritic-cDC_activated\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	KLF12 GPR157 LOXL2 IRF1 LYST	3.26e-06	192	53	5	e44e37e5aeba8628556020d05e1606b28e2faa4f
Drug	p001	VILL LYST	5.32e-06	2	53	2	CID005320521
Drug	AC1NSJZ2	CHRM1 CHRM5 GNL3	7.91e-06	17	53	3	CID005311091
Drug	tripitramine	CHRM1 CHRM5 GNL3	9.48e-06	18	53	3	CID000132947
Drug	hexocyclium	CHRM1 CHRM5	3.18e-05	4	53	2	CID000024199
Drug	Botiacrine	CHRM1 CHRM5	3.18e-05	4	53	2	CID000071202
Drug	Atropine	CHRM1 CHRM5	5.29e-05	5	53	2	DB00572
Drug	Fesoterodine	CHRM1 CHRM5	5.29e-05	5	53	2	DB06702
Drug	Darifenacin	CHRM1 CHRM5	5.29e-05	5	53	2	DB00496
Drug	Metixene	CHRM1 CHRM5	5.29e-05	5	53	2	DB00340
Drug	Trihexyphenidyl	CHRM1 CHRM5	5.29e-05	5	53	2	DB00376
Drug	Solifenacin	CHRM1 CHRM5	5.29e-05	5	53	2	DB01591
Drug	5-(3-(3-hydroxyphenoxy)azetidin-1-yl)-5-methyl-2,2-diphenylhexanamide	CHRM1 CHRM5	5.29e-05	5	53	2	ctd:C568516
Drug	Pipecuronium	CHRM1 CHRM5	5.29e-05	5	53	2	ctd:D017300
Drug	N-Methylscopolamine	CHRM1 CHRM5	5.29e-05	5	53	2	ctd:D019832
Drug	F 2268	CHRM1 CHRM5	5.29e-05	5	53	2	CID000020410
Drug	eucatropine	CHRM1 CHRM5	5.29e-05	5	53	2	CID000007534
Drug	Tolterodine	CHRM1 CHRM5	5.29e-05	5	53	2	DB01036
Drug	Cryptenamine	CHRM1 CHRM5	5.29e-05	5	53	2	DB00785
Drug	Homatropine Methylbromide	CHRM1 CHRM5	5.29e-05	5	53	2	DB00725
Drug	hexahydro-difenidol	CHRM1 CHRM5	5.29e-05	5	53	2	CID000124226
Drug	Quinuclidinyl Benzilate	CHRM1 CHRM5	5.29e-05	5	53	2	ctd:D011813
Drug	Nsc34399	CHRM1 CHRM5	7.93e-05	6	53	2	CID000003622
Drug	Gallamine Triethiodide	CHRM1 CHRM5	7.93e-05	6	53	2	ctd:D005703
Drug	Dactil	CHRM1 CHRM5	7.93e-05	6	53	2	CID000004839
Drug	4-diphenylacetoxy-1,1-dimethylpiperidinium	CHRM1 CHRM5	7.93e-05	6	53	2	ctd:C042375
Drug	brucine N-oxide	CHRM1 CHRM5	7.93e-05	6	53	2	ctd:C083067
Drug	Brompheniramine	CHRM1 CHRM5	7.93e-05	6	53	2	DB00835
Drug	Benzquinamide	CHRM1 CHRM5	7.93e-05	6	53	2	DB00767
Drug	Scopolamine	CHRM1 CHRM5	7.93e-05	6	53	2	DB00747
Drug	Crotalid Venoms	CHRM1 CHRM5	7.93e-05	6	53	2	ctd:D003435
Drug	AC1L1AYE	CHRM1 CHRM5 GNL3	8.05e-05	36	53	3	CID000001205
Drug	Fenbufen [36330-85-5]; Up 200; 15.8uM; MCF7; HT_HG-U133A	KLF12 CLCN4 LOXL2 AGXT ZNF471	8.57e-05	193	53	5	4743_UP
Drug	Ketoconazole [65277-42-1]; Up 200; 7.6uM; MCF7; HT_HG-U133A	KLF12 SLC9A5 ADGRF5 ZNF471 KIF17	9.44e-05	197	53	5	5685_UP
Drug	Metoclopramide monohydrochloride [7232-21-5]; Up 200; 11.8uM; MCF7; HT_HG-U133A	KLF12 SLC9A5 CLCN4 STAG3 VPS13B	9.90e-05	199	53	5	2315_UP
Drug	doxepin	LOXL2 CHRM1 CHRM5	1.11e-04	40	53	3	CID000003158
Drug	BMS-189090	IL31RA LYST	1.11e-04	7	53	2	CID000002417
Drug	Tiotropium Bromide	CHRM1 CHRM5	1.11e-04	7	53	2	ctd:D000069447
Drug	N-methylscopolamine	PI4KA CHRM1 CHRM5	1.28e-04	42	53	3	CID000004120
Drug	AC1LAD18	LOXL2 MAP3K10 CHRM1	1.47e-04	44	53	3	CID000466138
Drug	secoverine	CHRM1 CHRM5	1.48e-04	8	53	2	CID000042470
Drug	aceclidine	CHRM1 CHRM5	1.48e-04	8	53	2	CID000001979
Drug	Pirenzepine	CHRM1 CHRM5	1.48e-04	8	53	2	ctd:D010890
Drug	Maprotiline	CHRM1 CHRM5	1.48e-04	8	53	2	DB00934
Drug	Paroxetine	CHRM1 CHRM5	1.48e-04	8	53	2	DB00715
Drug	DGM-2	CHRM1 LYST	1.89e-04	9	53	2	CID000016891
Drug	Rilapinum	CHRM1 CHRM5	1.89e-04	9	53	2	CID006446980
Drug	Trest	CHRM1 CHRM5	1.89e-04	9	53	2	CID000004167
Drug	methylfurmethide	CHRM1 CHRM5	1.89e-04	9	53	2	CID000004141
Drug	sila-hexocyclium	CHRM1 CHRM5	1.89e-04	9	53	2	CID000130169
Drug	DL-tryptophan	DST LOXL2 CHRM1 LYST	2.12e-04	126	53	4	CID000001148
Drug	Promethazine	CHRM1 CHRM5	2.36e-04	10	53	2	DB01069
Drug	tenilapine	CHRM1 CHRM5	2.36e-04	10	53	2	CID006450478
Drug	AC1L3YF4	CHRM1 GNL3	2.36e-04	10	53	2	CID000124431
Drug	homatropin	CHRM1 CHRM5	2.89e-04	11	53	2	CID000003623
Drug	Imipramine	CHRM1 CHRM5	2.89e-04	11	53	2	DB00458
Drug	Pancuronium	CHRM1 CHRM5	2.89e-04	11	53	2	ctd:D010197
Drug	cyclopentolate	CHRM1 CHRM5	2.89e-04	11	53	2	CID000002905
Drug	dicyclomine	CHRM1 CHRM5	2.89e-04	11	53	2	CID000003042
Drug	rocuronium	CHRM1 CHRM5	2.89e-04	11	53	2	ctd:C061870
Disease	response to angiotensin-converting enzyme inhibitor, Cough	GYS2 PKD1L2 VPS13B	7.86e-05	46	53	3	EFO_0005325, HP_0012735
Disease	sexual dimorphism measurement	SPTBN5 CRISPLD2 G6PC3 DNAH10 LOXL2 RGPD1 IRF1 PHIP	7.52e-04	1106	53	8	EFO_0021796
Disease	non-high density lipoprotein cholesterol measurement	KLF12 DNAH10 TYW1B IRF1 ZNF471 WDR72	1.70e-03	713	53	6	EFO_0005689

Protein segments in the cluster

Peptide	Gene	Start	Entry
ASEVKLCAFVTWSDW	ERI2	141	A8K979
LALCQADKEFVWSLW	CNTLN	116	Q9NXG0
NLDRWKGDLWEACSV	GYS2	126	P54840
SIWEFIKSLLDAWSG	CLCN4	56	P51793
PEWFIGDWLECSKTC	ADAMTS6	901	Q9UKP5
KGTERVWLWTACDFA	RANBP2	2396	P49792
VWLWTACDFADGERK	RANBP2	2401	P49792
WDINKDACLFRSWAI	IRF1	46	P10914
SKSSDVWSFGVLLWE	MAP3K10	281	Q02779
LRCAVKESKFWSDWS	IL31RA	201	Q8NI17
ACDWWSLGAVLFELL	RPS6KC1	981	Q96S38
KWDSLTGQLSDRCDW	DST	4716	Q03001
GLDLSWSISLAFKWC	G6PC3	221	Q9BUM1
EWGTVCDDKWDLVSA	LOXL2	346	Q9Y4K0
GDWSTLKSFVCAWNL	DYNC2I2	186	Q96EX3
LIFAKEDSQSDGFWW	PDE8B	136	O95263
LEKSAAAWASQCIWE	CRISPLD2	86	Q9H0B8
LACWEWLLAGKDGVE	PI4KA	1231	P42356
GWWLDICSLEMFDAT	MARCHF6	391	O60337
FWLGDDLRSWEAAKL	TWNK	306	Q96RR1
ARDWWSTILGDKEEF	BBS9	6	Q3SYG4
ETWGYFCSKWNLLEL	PKD1L2	2211	Q7Z442
GEWKTAEKWFLDALE	CDC16	416	Q13042
DDKNAWFAIDLGLWV	HECTD1	1131	Q9ULT8
WWDAEADKSLLIGVF	CHD6	1276	Q8TD26
DVSVGWCWIDLEAKD	GPR157	151	Q5UAW9
WALGTLACDLWLALD	CHRM1	91	P11229
SGSEDLLWKWDALKA	LYST	681	Q99698
AAKLLWSEWTGASLA	GNL3	386	Q9BVP2
WEGCTWKFARSDELT	KLF12	351	Q9Y4X4
CAWLSDQGWEDIILL	DNAH10	3766	Q8IVF4
GCWKDDLQKELSDIW	CCDC159	216	P0C7I6
DCEGEDGWNKLFDWI	RGPD1	131	P0DJD0
LRESCWDEDNGFWKI	KIF17	881	Q9P2E2
YLDIKWLANFWGCDD	AGXT	241	P21549
CLWEELLKEDLVWGA	TATDN2	546	Q93075
IIGSWFWAEKEASLE	GPRASP2	386	Q96D09
LLGISAVDSSKWAWD	SLC9A5	346	Q14940
LWDCAGTQLKDWEGL	STAG3L1	166	P0CL83
WLCSKEDSLASEGLW	SPTBN5	2591	Q9NRC6
QAEAWLACWEGLLLK	SPTBN5	3431	Q9NRC6
WALGSLACDLWLALD	CHRM5	96	P08912
VCWLNWEDTKALLAF	ADGRF5	1161	Q8IZF2
LEWSLFDDLATWKGC	TRIM13	336	O60858
ADGTICFWLWDAGTL	PHIP	291	Q8WWQ0
LWDCAGARLKDWEGL	STAG3	501	Q9UJ98
WMLSGDLDSCVILWD	WDR72	481	Q3MJ13
LTEACDWWSFGSLLY	RPS6KL1	461	Q9Y6S9
IFLWLGEAASEWKEA	VILL	651	O15195
EWELTAAKADCWLRA	VWA5B2	1186	Q8N398
LECSTFEENWKWEDL	ZNF471	116	Q9BX82
LINESKWDLWLFEGE	VPS13B	2991	Q7Z7G8
DGLPTESAEWFCKWL	TYW1	141	Q9NV66
ESAEWFCKWLEEASI	TYW1	146	Q9NV66
GLPTESAEWFCKWLE	TYW1B	96	Q6NUM6
SAEWFCKWLEEASID	TYW1B	101	Q6NUM6
ASEKKWAFSDEWVAC	GEMIN4	426	P57678