Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCC4 ABCA5 ABCA7 ABCG8 ABCB8	7.29e-08	49	44	5	GO:0140359
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	MPL TAS1R2 OR2J1 CCR3 NPY4R2 ACKR2 GPR19 OR5AC2 KIR2DL4 NPY4R PLXNB2 GPR32 ABCA7 OR9Q2 TLR3	9.54e-08	1353	44	15	GO:0004888
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCC4 ABCA5 ABCA7 ABCG8 ABCB8	4.05e-06	109	44	5	GO:0042626
GeneOntologyMolecularFunction	G protein-coupled receptor activity	TAS1R2 OR2J1 CCR3 NPY4R2 ACKR2 GPR19 OR5AC2 NPY4R GPR32 OR9Q2	1.73e-05	884	44	10	GO:0004930
GeneOntologyMolecularFunction	pancreatic polypeptide receptor activity	NPY4R2 NPY4R	2.84e-05	4	44	2	GO:0001602
GeneOntologyMolecularFunction	immune receptor activity	MPL CCR3 ACKR2 KIR2DL4 GPR32	3.03e-05	165	44	5	GO:0140375
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	ABCC4 ABCA5 ABCA7 ABCG8 ABCB8	4.36e-05	178	44	5	GO:0015399
GeneOntologyMolecularFunction	lipid transporter activity	ABCC4 ABCA5 ABCA7 ABCG8 ATP10D	6.89e-05	196	44	5	GO:0005319
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC37A1 ABCC4 SLC44A1 ABCA5 ABCA7 ABCG8 ABCB8	7.57e-05	477	44	7	GO:0022804
GeneOntologyMolecularFunction	transporter activity	SLC37A1 PEX2 GJA3 ABCC4 SLC44A1 ABCA5 SLC38A9 ABCA7 ABCG8 ATP10D ABCB8	8.23e-05	1289	44	11	GO:0005215
GeneOntologyMolecularFunction	alcohol transmembrane transporter activity	ABCC4 SLC44A1	1.32e-04	8	44	2	GO:0015665
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC37A1 PEX2 GJA3 ABCC4 SLC44A1 ABCA5 SLC38A9 ABCA7 ABCG8 ABCB8	1.96e-04	1180	44	10	GO:0022857
GeneOntologyMolecularFunction	neuropeptide Y receptor activity	NPY4R2 NPY4R	2.58e-04	11	44	2	GO:0004983
GeneOntologyMolecularFunction	ATP hydrolysis activity	ABCC4 ABCA5 ABCA7 ABCG8 ATP10D ABCB8	3.89e-04	441	44	6	GO:0016887
GeneOntologyMolecularFunction	C-C chemokine receptor activity	CCR3 ACKR2	1.17e-03	23	44	2	GO:0016493
GeneOntologyMolecularFunction	C-C chemokine binding	CCR3 ACKR2	1.27e-03	24	44	2	GO:0019957
GeneOntologyMolecularFunction	cytokine receptor activity	MPL CCR3 ACKR2	1.27e-03	97	44	3	GO:0004896
GeneOntologyMolecularFunction	G protein-coupled chemoattractant receptor activity	CCR3 ACKR2	1.49e-03	26	44	2	GO:0001637
GeneOntologyMolecularFunction	chemokine receptor activity	CCR3 ACKR2	1.49e-03	26	44	2	GO:0004950
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ABCA7 ATP10D	1.73e-03	28	44	2	GO:0140326
GeneOntologyMolecularFunction	ATP-dependent activity	ABCC4 ABCA5 ABCA7 ABCG8 ATP10D ABCB8	2.15e-03	614	44	6	GO:0140657
GeneOntologyMolecularFunction	chemokine binding	CCR3 ACKR2	2.40e-03	33	44	2	GO:0019956
GeneOntologyMolecularFunction	neuropeptide binding	NPY4R2 NPY4R	3.01e-03	37	44	2	GO:0042923
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	NPY4R2 NPY4R GPR32	3.13e-03	133	44	3	GO:0008528
GeneOntologyMolecularFunction	organophosphate ester transmembrane transporter activity	SLC37A1 ABCC4	3.34e-03	39	44	2	GO:0015605
GeneOntologyMolecularFunction	peptide receptor activity	NPY4R2 NPY4R GPR32	3.62e-03	140	44	3	GO:0001653
GeneOntologyMolecularFunction	amide transmembrane transporter activity	ABCC4 SLC38A9	3.86e-03	42	44	2	GO:0042887
GeneOntologyMolecularFunction	intramembrane lipid transporter activity	ABCA7 ATP10D	5.65e-03	51	44	2	GO:0140303
GeneOntologyMolecularFunction	neuropeptide receptor activity	NPY4R2 NPY4R	6.09e-03	53	44	2	GO:0008188
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	ABCC4 ABCA5 ABCA7 ABCG8 ATP10D ABCB8	6.73e-03	775	44	6	GO:0017111
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	FAXDC2 FMO3 FADS2B	8.93e-03	194	44	3	GO:0016705
GeneOntologyMolecularFunction	pyrophosphatase activity	ABCC4 ABCA5 ABCA7 ABCG8 ATP10D ABCB8	9.77e-03	839	44	6	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	ABCC4 ABCA5 ABCA7 ABCG8 ATP10D ABCB8	9.82e-03	840	44	6	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	ABCC4 ABCA5 ABCA7 ABCG8 ATP10D ABCB8	9.82e-03	840	44	6	GO:0016818
GeneOntologyMolecularFunction	organic hydroxy compound transmembrane transporter activity	ABCC4 SLC44A1	1.04e-02	70	44	2	GO:1901618
GeneOntologyMolecularFunction	amino acid binding	FMO3 SLC38A9	1.13e-02	73	44	2	GO:0016597
GeneOntologyMolecularFunction	organic cation transmembrane transporter activity	SLC44A1 SLC38A9	1.44e-02	83	44	2	GO:0015101
GeneOntologyMolecularFunction	cargo receptor activity	ACKR2 ABCA7	1.51e-02	85	44	2	GO:0038024
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	MPL TAS1R2 OR2J1 CCR3 NPY4R2 ACKR2 GPR19 OR5AC2 NPY4R GPR32 DAGLA ADCY9 OR9Q2	4.20e-06	1395	44	13	GO:0007186
GeneOntologyBiologicalProcess	organophosphate ester transport	SLC37A1 ABCC4 ABCA7 ABCG8 ATP10D	2.38e-05	162	44	5	GO:0015748
GeneOntologyCellularComponent	endosome	TMEM192 CCR3 ACKR2 UNC93B1 DCSTAMP KIR2DL4 ABCA5 SLC38A9 DAGLA ABCA7 TLR3	2.74e-05	1167	45	11	GO:0005768
GeneOntologyCellularComponent	ATP-binding cassette (ABC) transporter complex	ABCG8 ABCB8	6.76e-05	6	45	2	GO:0043190
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	LPCAT4 SLC37A1 FAXDC2 UNC93B1 FMO3 EMD DCSTAMP FADS2B ATP10D OR9Q2 TLR3	7.30e-05	1299	45	11	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	LPCAT4 SLC37A1 FAXDC2 UNC93B1 FMO3 EMD DCSTAMP FADS2B ATP10D OR9Q2 TLR3	8.85e-05	1327	45	11	GO:0042175
GeneOntologyCellularComponent	endosome membrane	DCSTAMP KIR2DL4 ABCA5 SLC38A9 DAGLA ABCA7 TLR3	2.78e-04	602	45	7	GO:0010008
GeneOntologyCellularComponent	endoplasmic reticulum membrane	LPCAT4 SLC37A1 FAXDC2 UNC93B1 FMO3 DCSTAMP FADS2B ATP10D OR9Q2 TLR3	3.45e-04	1293	45	10	GO:0005789
GeneOntologyCellularComponent	cell surface	MPL CCR3 ABCC4 ACKR2 DCSTAMP PLXNB2 ABCA7 TLR3 PDCD1LG2	5.13e-04	1111	45	9	GO:0009986
HumanPheno	Abnormal CSF glucose concentration	UNC93B1 TLR3	6.33e-05	6	11	2	HP:0031884
HumanPheno	Hypoglycorrhachia	UNC93B1 TLR3	6.33e-05	6	11	2	HP:0011972
Domain	ABC_transporter_CS	ABCC4 ABCA5 ABCA7 ABCG8 ABCB8	4.06e-08	42	43	5	IPR017871
Domain	ABC_TRANSPORTER_2	ABCC4 ABCA5 ABCA7 ABCG8 ABCB8	8.09e-08	48	43	5	PS50893
Domain	ABC_tran	ABCC4 ABCA5 ABCA7 ABCG8 ABCB8	8.09e-08	48	43	5	PF00005
Domain	ABC_TRANSPORTER_1	ABCC4 ABCA5 ABCA7 ABCG8 ABCB8	9.00e-08	49	43	5	PS00211
Domain	ABC_transporter-like	ABCC4 ABCA5 ABCA7 ABCG8 ABCB8	9.98e-08	50	43	5	IPR003439
Domain	NPY4_rcpt	NPY4R2 NPY4R	5.18e-06	2	43	2	IPR001933
Domain	7tm_1	OR2J1 CCR3 NPY4R2 ACKR2 GPR19 OR5AC2 NPY4R GPR32 OR9Q2	1.91e-05	677	43	9	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR2J1 CCR3 NPY4R2 ACKR2 GPR19 OR5AC2 NPY4R GPR32 OR9Q2	2.10e-05	685	43	9	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2J1 CCR3 NPY4R2 ACKR2 GPR19 OR5AC2 NPY4R GPR32 OR9Q2	2.25e-05	691	43	9	PS50262
Domain	GPCR_Rhodpsn	OR2J1 CCR3 NPY4R2 ACKR2 GPR19 OR5AC2 NPY4R GPR32 OR9Q2	2.27e-05	692	43	9	IPR000276
Domain	GPCR_Rhodpsn_7TM	CCR3 NPY4R2 ACKR2 GPR19 OR5AC2 NPY4R GPR32 OR9Q2	1.25e-04	670	43	8	IPR017452
Domain	NPY_rcpt	NPY4R2 NPY4R	1.84e-04	9	43	2	IPR000611
Domain	AAA+_ATPase	ABCC4 ABCA5 ABCA7 ABCB8	3.31e-04	144	43	4	IPR003593
Domain	AAA	ABCC4 ABCA5 ABCA7 ABCB8	3.31e-04	144	43	4	SM00382
Domain	ABC_A	ABCA5 ABCA7	3.37e-04	12	43	2	IPR026082
Domain	Chemokine_rcpt	CCR3 ACKR2	6.09e-04	16	43	2	IPR000355
Domain	ABC_membrane	ABCC4 ABCB8	1.38e-03	24	43	2	PF00664
Domain	ABC_TM1F	ABCC4 ABCB8	1.88e-03	28	43	2	PS50929
Domain	ABC1_TM_dom	ABCC4 ABCB8	1.88e-03	28	43	2	IPR011527
Pathway	KEGG_ABC_TRANSPORTERS	ABCC4 ABCA5 ABCA7 ABCG8 ABCB8	6.10e-08	44	34	5	M11911
Pathway	REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT	ABCC4 ABCA5 ABCA7 ABCG8 ABCB8	3.65e-06	99	34	5	MM14986
Pathway	REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT	ABCC4 ABCA5 ABCA7 ABCG8 ABCB8	4.44e-06	103	34	5	M758
Pathway	REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS	ABCA5 ABCA7 ABCG8	8.52e-06	17	34	3	MM14552
Pathway	REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS	ABCA5 ABCA7 ABCG8	1.02e-05	18	34	3	M524
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	OR2J1 CCR3 ACKR2 GPR19 NPY4R GPR32	3.24e-05	260	34	6	M39397
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	ABCC4 SLC44A1 ABCA5 ABCA7 ABCG8 ADCY9 ATP10D ABCB8	2.87e-04	736	34	8	M27287
Pathway	REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR	UNC93B1 TLR3	4.33e-04	13	34	2	M593
Pathway	WP_CHOLESTASIS	ABCC4 ABCG8	9.41e-04	19	34	2	M45520
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	CCR3 ACKR2 GPR19 NPY4R	9.99e-04	186	34	4	MM15994
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	ABCC4 SLC44A1 ABCA5 ABCA7 ABCG8 ATP10D ABCB8	1.02e-03	681	34	7	MM14985
Pathway	REACTOME_SIGNALING_BY_GPCR	TAS1R2 CCR3 ACKR2 NPY4R GPR32 DAGLA ADCY9	1.22e-03	702	34	7	M746
Pubmed	The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists.	UNC93B1 TLR3	1.64e-06	2	45	2	23166319
Pubmed	Is it time to study TLR3 or UNC-93B pathway deficiencies in reactivated herpes simplex encephalitis?	UNC93B1 TLR3	1.64e-06	2	45	2	21173679
Pubmed	HCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling pathways.	UNC93B1 TLR3	1.64e-06	2	45	2	31604943
Pubmed	Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling.	UNC93B1 TLR3	1.64e-06	2	45	2	22611194
Pubmed	Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.	ABCC4 ABCA5 ABCB8	3.06e-06	22	45	3	8894702
Pubmed	Autophagy downstream of endosomal Toll-like receptor signaling in macrophages is a key mechanism for resistance to Leishmania major infection.	UNC93B1 TLR3	4.91e-06	3	45	2	28607148
Pubmed	Acidic amino acid residues in the juxtamembrane region of the nucleotide-sensing TLRs are important for UNC93B1 binding and signaling.	UNC93B1 TLR3	4.91e-06	3	45	2	23585677
Pubmed	Dynamic control of nucleic-acid-sensing Toll-like receptors by the endosomal compartment.	UNC93B1 TLR3	4.91e-06	3	45	2	34223897
Pubmed	B Cell-intrinsic TLR7 signaling is required for optimal B cell responses during chronic viral infection.	UNC93B1 TLR3	4.91e-06	3	45	2	23761632
Pubmed	Cryo-EM structures of Toll-like receptors in complex with UNC93B1.	UNC93B1 TLR3	4.91e-06	3	45	2	33432245
Pubmed	Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.	NPY4R2 NPY4R	4.91e-06	3	45	2	8643460
Pubmed	The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.	UNC93B1 TLR3	4.91e-06	3	45	2	29768176
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	ABCC4 ABCA5 ABCA7 ABCG8 ABCB8	5.10e-06	193	45	5	19343046
Pubmed	The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling.	UNC93B1 TLR3	9.81e-06	4	45	2	17452530
Pubmed	Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing.	UNC93B1 TLR3	9.81e-06	4	45	2	19451267
Pubmed	Type I interferon is a therapeutic target for virus-induced lethal vascular damage.	UNC93B1 TLR3	9.81e-06	4	45	2	24889626
Pubmed	Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver.	ABCA5 ABCA7	9.81e-06	4	45	2	16445568
Pubmed	Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.	NPY4R2 NPY4R	9.81e-06	4	45	2	7592911
Pubmed	Rel-Dependent Immune and Central Nervous System Mechanisms Control Viral Replication and Inflammation during Mouse Herpes Simplex Encephalitis.	UNC93B1 TLR3	9.81e-06	4	45	2	30683700
Pubmed	UNC93B1 and nucleic acid-sensing Toll-like receptors mediate host resistance to infection with Leishmania major.	UNC93B1 TLR3	1.63e-05	5	45	2	23325805
Pubmed	Gurmarin sensitivity of sweet taste responses is associated with co-expression patterns of T1r2, T1r3, and gustducin.	TAS1R2 TLR3	1.63e-05	5	45	2	18174025
Pubmed	Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice.	UNC93B1 TLR3	1.63e-05	5	45	2	23290966
Pubmed	Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.	NPY4R2 NPY4R	1.63e-05	5	45	2	7493937
Pubmed	Macrophages recognize streptococci through bacterial single-stranded RNA.	UNC93B1 TLR3	1.63e-05	5	45	2	21164516
Pubmed	LRRC59 Regulates Trafficking of Nucleic Acid-Sensing TLRs from the Endoplasmic Reticulum via Association with UNC93B1.	UNC93B1 TLR3	2.45e-05	6	45	2	26466955
Pubmed	Nucleic Acid-Sensing Toll-Like Receptors Play a Dominant Role in Innate Immune Recognition of Pneumococci.	UNC93B1 TLR3	2.45e-05	6	45	2	32209688
Pubmed	Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8.	ABCA7 ABCG8	2.45e-05	6	45	2	12111378
Pubmed	UNC93B1 mediates host resistance to infection with Toxoplasma gondii.	UNC93B1 TLR3	2.45e-05	6	45	2	20865117
Pubmed	Age-dependent myeloid dendritic cell responses mediate resistance to la crosse virus-induced neurological disease.	UNC93B1 TLR3	3.42e-05	7	45	2	25008929
Pubmed	Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors.	UNC93B1 TLR3	3.42e-05	7	45	2	23142781
Pubmed	Crosstalk between components of the innate immune system: promoting anti-microbial defenses and avoiding immunopathologies.	UNC93B1 TLR3	5.86e-05	9	45	2	19120481
Pubmed	Increased susceptibility to DNA virus infection in mice with a GCN2 mutation.	UNC93B1 TLR3	5.86e-05	9	45	2	22114338
Pubmed	IL-1R1/MyD88 signaling is critical for elastase-induced lung inflammation and emphysema.	UNC93B1 TLR3	5.86e-05	9	45	2	20007584
Pubmed	Neutrophils Enhance Their Own Influx to Sites of Bacterial Infection via Endosomal TLR-Dependent Cxcl2 Production.	UNC93B1 TLR3	7.32e-05	10	45	2	31852751
Pubmed	Bacterial RNA mediates activation of caspase-1 and IL-1β release independently of TLRs 3, 7, 9 and TRIF but is dependent on UNC93B.	UNC93B1 TLR3	8.94e-05	11	45	2	22634614
Pubmed	MyD88-dependent signaling contributes to host defense against ehrlichial infection.	UNC93B1 TLR3	1.07e-04	12	45	2	20668698
Pubmed	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	CCR3 ABCC4 ABCA5 ABCA7 ABCG8	1.31e-04	381	45	5	18676680
Pubmed	Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.	CCR3 ABCC4 ABCA5 ABCA7 ABCG8	1.33e-04	382	45	5	19170196
Pubmed	SNAT7 regulates mTORC1 via macropinocytosis.	TMEM192 SLC38A9	1.47e-04	14	45	2	35561222
Pubmed	Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5.	CCR3 ACKR2	1.70e-04	15	45	2	9139699
Pubmed	Neutrophils Directly Recognize Group B Streptococci and Contribute to Interleukin-1β Production during Infection.	UNC93B1 TLR3	1.70e-04	15	45	2	27509078
Pubmed	Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.	LPCAT4 DENND5B SLC44A1 DAGLA ADCY9	1.74e-04	405	45	5	38187761
Pubmed	Genetic susceptibility to distinct bladder cancer subphenotypes.	CCR3 ABCC4 ABCA5 ABCA7 ABCG8	2.08e-04	421	45	5	19692168
Pubmed	DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.	UNC93B1 TLR3	2.47e-04	18	45	2	22541070
Pubmed	TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.	UNC93B1 TLR3	2.76e-04	19	45	2	28400473
Pubmed	RNF115 Inhibits the Post-ER Trafficking of TLRs and TLRs-Mediated Immune Responses by Catalyzing K11-Linked Ubiquitination of RAB1A and RAB13.	UNC93B1 TLR3	2.76e-04	19	45	2	35343654
Pubmed	Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation.	CCR3 ACKR2	3.06e-04	20	45	2	25340798
Pubmed	Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.	ABCA7 ABCB8	4.07e-04	23	45	2	10708515
Pubmed	Defining the membrane proteome of NK cells.	LPCAT4 SLC37A1 PEX2 ABCC4 SLC44A1 EMD KIR2DL4	7.04e-04	1168	45	7	19946888
Pubmed	Expression profiles and pathway analysis in HEK 293 T cells overexpressing HIV-1 Tat and nucleocapsid using cDNA microarray.	FMO3 TARBP1	1.24e-03	40	45	2	18051367
Interaction	TTYH1 interactions	LPCAT4 TMEM192 ABCC4 SLC44A1 UNC93B1 DAGLA ABCA7 ADCY9	1.37e-07	300	41	8	int:TTYH1
Interaction	C3orf52 interactions	LPCAT4 ABCC4 KIR2DL4 ABCA5 DAGLA ABCA7 ADCY9	2.46e-06	305	41	7	int:C3orf52
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	MPL CCR3 SLC44A1 KIR2DL4 TLR3 PDCD1LG2	1.15e-04	394	36	6	471
GeneFamily	ATP binding cassette subfamily A	ABCA5 ABCA7	3.46e-04	14	36	2	805
GeneFamily	G protein-coupled receptors, Class A orphans	GPR19 GPR32	1.05e-02	78	36	2	262
Drug	docetaxel	ABCC4 FMO3 ABCA5 ABCA7 ABCB8	4.51e-06	133	42	5	ctd:C067311
Disease	Herpetic Acute Necrotizing Encephalitis	UNC93B1 TLR3	2.17e-05	5	44	2	C0001338
Disease	Herpetic meningoencephalitis	UNC93B1 TLR3	3.25e-05	6	44	2	C0019385
Disease	Herpes encephalitis	UNC93B1 TLR3	4.54e-05	7	44	2	C0276226
Disease	lactosyl-N-nervonoyl-sphingosine (d18:1/24:1) measurement	SLC44A1 ABCA7	7.77e-05	9	44	2	EFO_0800517
Disease	COVID-19, osteoarthritis	CCR3 ACKR2	4.06e-04	20	44	2	MONDO_0005178, MONDO_0100096
Disease	hepatitis B (is_marker_for)	MPL CCR3	4.48e-04	21	44	2	DOID:2043 (is_marker_for)
Disease	serum metabolite measurement	PAQR9 ABCC4 FMO3 DNAJA4 ABCA7 ATP10D ABCB8	4.60e-04	945	44	7	EFO_0005653
Disease	CCL2 measurement	CCR3 ACKR2 ABCA7	8.86e-04	126	44	3	EFO_0004749
Disease	hepatitis C (is_marker_for)	MPL TLR3	1.25e-03	35	44	2	DOID:1883 (is_marker_for)
Disease	asthma (implicated_via_orthology)	CCR3 TLR3	1.25e-03	35	44	2	DOID:2841 (implicated_via_orthology)
Disease	metabolite measurement	ABCC4 FMO3 ABCG8 ATP10D ABCB8	1.43e-03	560	44	5	EFO_0004725
Disease	Parkinson disease, disease progression measurement	GPR19 GPR32	1.55e-03	39	44	2	EFO_0008336, MONDO_0005180
Disease	sphingolipid measurement	ABCA7 ATP10D	1.64e-03	40	44	2	EFO_0004622
Disease	cholestasis (biomarker_via_orthology)	ABCC4 ABCG8	2.44e-03	49	44	2	DOID:13580 (biomarker_via_orthology)
Disease	Liver Cirrhosis, Experimental	PAQR9 UNC93B1 ABCG8 ATP10D CNPY4	5.72e-03	774	44	5	C0023893

Protein segments in the cluster

Peptide	Gene	Start	Entry
ILFPLFFLFWLILIS	ABCA5	36	Q8WWZ7
VLWFPYNLTLFLHTL	ACKR2	261	O00590
LGILLFLFLAVHEAW	CNPY4	6	Q8N129
LNLLFLLSWLPFHVA	GPR19	281	Q15760
FIFWSPFNVVLLVHL	GPR32	266	O75388
QPFLLHFLLVWLVVF	ABCG8	526	Q9H221
LIIQFLVIFPEKHWL	DNAJA4	321	Q8WW22
LYFLFLVVLNWVPLV	ATP10D	101	Q9P241
LVELLWPLFLFFILV	ABCA7	26	Q8IZY2
WPLFLFFILVAVRHS	ABCA7	31	Q8IZY2
WLLHIFIPFCIIAFI	PDCD1LG2	221	Q9BQ51
AFTEHLQWRVPLFLI	OR9Q2	16	Q8NGE9
WPHLEVVLFVVILIF	OR2J1	21	Q9GZK6
FFHWLKLFAIPILLI	FMO3	511	P31513
VLLAFIVLFLLWPFA	LPCAT4	51	Q643R3
VVAFAVLWLPLHVFN	NPY4R	271	P50391
PQHSFFFLLLLWLPD	IGKV3D-7	6	A0A0C4DH55
HILFVFLPFLWALGT	PCNX4	246	Q63HM2
LRFWVNILKNPHFIF	PLXNB2	1686	O15031
LWHGFAEFLIFLLPL	PEX2	196	P28328
FFLPILIHLCIWVLF	DCSTAMP	296	Q9H295
NFWTHFIPLLLFLSK	PAQR9	86	Q6ZVX9
FLHFVQILILEVLAW	FADS2B	171	A8MWK0
DRPWLHVLFFVVFLV	OR5AC2	21	Q9NZP5
IILFTILPFFLLHRW	KIR2DL4	251	Q99706
RAGAHWIVFIFLILL	ABCC4	706	O15439
FLFWLPLYITNVDHL	SLC37A1	346	P57057
PTFHWFLLELAIFTL	FAXDC2	166	Q96IV6
LLFLVTLPFWIHYVR	CCR3	81	P51677
LLFPFQWQHVYVPIL	DENND5B	316	Q6ZUT9
EVVLVFFLLLLLVWF	ADCY9	981	O60503
PAIFLFLLHTTWFVI	DAGLA	21	Q9Y4D2
KVFIHLPLLVFQPFW	SLC44A1	326	Q8WWI5
WGQLLLFLVFVIVLF	EMD	226	P50402
PISHIRFWALQIIFV	GJA3	71	Q9Y6H8
LTWPKLIFHVFIIIL	SLC38A9	536	Q8NBW4
LFWQFLHPHLLVLGV	ABCB8	136	Q9NUT2
FFLVIHPLGNFWLIL	PTCHD4	676	Q6ZW05
VNLLWFIHLVFVVLA	TMEM192	51	Q8IY95
FIFIVLLIHFEGWRI	TLR3	716	O15455
VHLLLTFILFFWAPV	UNC93B1	411	Q9H1C4
RHIFPLPLLFSHFLW	nan	86	Q6ZSR6
VVAFAVLWLPLHVFN	NPY4R2	271	P0DQD5
VRLFFPLHLWVKNVF	MPL	101	P40238
LAILVIFWRHFQTPI	TAS1R2	581	Q8TE23
LVLLPVFLHVASWHF	ZDHHC23	96	Q8IYP9
IEWIIILILHKFPQF	TARBP1	1211	Q13395
ILILHKFPQFLPKFW	TARBP1	1216	Q13395