Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cargo receptor activity	CD44 DMBT1 CUBN LRP10	1.00e-05	85	32	4	GO:0038024
GeneOntologyMolecularFunction	serine-type endopeptidase activity	KLK8 MST1 MST1L PLG	2.32e-04	190	32	4	GO:0004252
GeneOntologyMolecularFunction	serine-type peptidase activity	KLK8 MST1 MST1L PLG	3.21e-04	207	32	4	GO:0008236
GeneOntologyMolecularFunction	serine hydrolase activity	KLK8 MST1 MST1L PLG	3.52e-04	212	32	4	GO:0017171
GeneOntologyMolecularFunction	receptor tyrosine kinase binding	MST1 MST1L TIAM1	4.00e-04	90	32	3	GO:0030971
GeneOntologyMolecularFunction	kinase binding	CD44 MST1 MST1L PLG TIAM1 RPTOR MAPKAPK3	7.18e-04	969	32	7	GO:0019900
GeneOntologyMolecularFunction	histone kinase activity	MST1 MST1L	9.16e-04	28	32	2	GO:0035173
GeneOntologyMolecularFunction	hyaluronic acid binding	CD44 CEMIP	9.83e-04	29	32	2	GO:0005540
GeneOntologyMolecularFunction	protein tyrosine kinase binding	MST1 MST1L TIAM1	1.72e-03	149	32	3	GO:1990782
GeneOntologyMolecularFunction	protein kinase binding	CD44 MST1 MST1L TIAM1 RPTOR MAPKAPK3	2.35e-03	873	32	6	GO:0019901
GeneOntologyMolecularFunction	clathrin binding	DNER CEMIP	4.57e-03	63	32	2	GO:0030276
GeneOntologyMolecularFunction	endopeptidase activity	KLK8 MST1 MST1L PLG	4.73e-03	430	32	4	GO:0004175
GeneOntologyBiologicalProcess	regulation of chemotaxis	MST1 MST1L CORO1B HDAC6 TIAM1	3.87e-05	242	33	5	GO:0050920
GeneOntologyBiologicalProcess	positive regulation of mammary gland epithelial cell proliferation	MST1 MST1L	8.87e-05	9	33	2	GO:0033601
GeneOntologyBiologicalProcess	mammary duct terminal end bud growth	MST1 MST1L	8.87e-05	9	33	2	GO:0060763
GeneOntologyBiologicalProcess	regulation of lamellipodium morphogenesis	CD44 CORO1B	1.35e-04	11	33	2	GO:2000392
GeneOntologyCellularComponent	clathrin-coated pit	CUBN LRP10 CEMIP	2.71e-04	80	33	3	GO:0005905
Domain	PAN_AP	MST1 MST1L PLG	4.56e-08	5	32	3	SM00473
Domain	PAN	MST1 MST1L PLG	1.59e-07	7	32	3	PS50948
Domain	Pan_app	MST1 MST1L PLG	1.59e-07	7	32	3	IPR003609
Domain	PAN_1	MST1 MST1L PLG	1.59e-07	7	32	3	PF00024
Domain	Kringle	MST1 MST1L PLG	3.06e-06	17	32	3	IPR000001
Domain	Kringle	MST1 MST1L PLG	3.06e-06	17	32	3	PF00051
Domain	KRINGLE_1	MST1 MST1L PLG	3.06e-06	17	32	3	PS00021
Domain	Kringle_CS	MST1 MST1L PLG	3.06e-06	17	32	3	IPR018056
Domain	KR	MST1 MST1L PLG	3.06e-06	17	32	3	SM00130
Domain	KRINGLE_2	MST1 MST1L PLG	3.06e-06	17	32	3	PS50070
Domain	Kringle-like	MST1 MST1L PLG	2.19e-05	32	32	3	IPR013806
Domain	Peptidase_S1A	KLK8 MST1 MST1L PLG	4.01e-05	113	32	4	IPR001314
Domain	TRYPSIN_DOM	KLK8 MST1 MST1L PLG	4.29e-05	115	32	4	PS50240
Domain	Tryp_SPc	KLK8 MST1 MST1L PLG	4.59e-05	117	32	4	SM00020
Domain	Trypsin	KLK8 MST1 MST1L PLG	5.24e-05	121	32	4	PF00089
Domain	Trypsin_dom	KLK8 MST1 MST1L PLG	5.24e-05	121	32	4	IPR001254
Domain	Peptidase_S1_PA	KLK8 MST1 MST1L PLG	5.58e-05	123	32	4	IPR009003
Domain	CUB	DMBT1 CUBN LRP10	7.98e-05	49	32	3	PF00431
Domain	CUB	DMBT1 CUBN LRP10	8.48e-05	50	32	3	SM00042
Domain	-	DMBT1 CUBN LRP10	9.54e-05	52	32	3	2.60.120.290
Domain	CUB	DMBT1 CUBN LRP10	1.01e-04	53	32	3	PS01180
Domain	CUB_dom	DMBT1 CUBN LRP10	1.26e-04	57	32	3	IPR000859
Domain	ZP_1	OIT3 DMBT1	2.55e-04	14	32	2	PS00682
Domain	ZP_2	OIT3 DMBT1	2.55e-04	14	32	2	PS51034
Domain	ZP	OIT3 DMBT1	2.94e-04	15	32	2	SM00241
Domain	ZP_dom	OIT3 DMBT1	3.81e-04	17	32	2	IPR001507
Domain	Zona_pellucida	OIT3 DMBT1	3.81e-04	17	32	2	PF00100
Domain	EGF_Ca-bd_CS	DNER OIT3 CUBN	6.04e-04	97	32	3	IPR018097
Domain	EGF_CA	DNER OIT3 CUBN	6.41e-04	99	32	3	PS01187
Domain	ASX_HYDROXYL	DNER OIT3 CUBN	6.60e-04	100	32	3	PS00010
Domain	EGF_3	DNER OIT3 CUBN SSPOP	6.66e-04	235	32	4	PS50026
Domain	EGF-type_Asp/Asn_hydroxyl_site	DNER OIT3 CUBN	7.82e-04	106	32	3	IPR000152
Domain	Cys_knot_C	GPHA2 SSPOP	8.32e-04	25	32	2	IPR006207
Domain	CTCK_2	GPHA2 SSPOP	8.32e-04	25	32	2	PS01225
Domain	EGF_1	DNER OIT3 CUBN SSPOP	9.03e-04	255	32	4	PS00022
Domain	EGF_2	DNER OIT3 CUBN SSPOP	1.04e-03	265	32	4	PS01186
Domain	EGF_CA	DNER OIT3 CUBN	1.17e-03	122	32	3	SM00179
Domain	EGF-like_Ca-bd_dom	DNER OIT3 CUBN	1.23e-03	124	32	3	IPR001881
Domain	LDLR_class-A_CS	LRP10 SSPOP	2.13e-03	40	32	2	IPR023415
Domain	Ldl_recept_a	LRP10 SSPOP	2.69e-03	45	32	2	PF00057
Domain	-	LRP10 SSPOP	2.81e-03	46	32	2	4.10.400.10
Domain	LDLRA_1	LRP10 SSPOP	3.05e-03	48	32	2	PS01209
Domain	LDrepeatLR_classA_rpt	LRP10 SSPOP	3.18e-03	49	32	2	IPR002172
Domain	LDLa	LRP10 SSPOP	3.18e-03	49	32	2	SM00192
Domain	LDLRA_2	LRP10 SSPOP	3.18e-03	49	32	2	PS50068
Domain	EGF	DNER OIT3 CUBN	7.45e-03	235	32	3	SM00181
Domain	EGF-like_dom	DNER OIT3 CUBN	8.73e-03	249	32	3	IPR000742
Domain	TRYPSIN_SER	KLK8 PLG	1.04e-02	90	32	2	IPR033116
Pathway	REACTOME_SIGNALING_BY_MST1	MST1 MST1L	4.51e-05	6	25	2	MM15492
Pathway	BIOCARTA_MSP_PATHWAY	MST1 MST1L	6.31e-05	7	25	2	MM1580
Pathway	WP_MIR302367_PROMOTING_CARDIOMYOCYTE_PROLIFERATION	MST1 MST1L	8.40e-05	8	25	2	MM15986
Pathway	REACTOME_HYALURONAN_METABOLISM	CD44 CEMIP	4.04e-04	17	25	2	M666
Pathway	REACTOME_HYALURONAN_METABOLISM	CD44 CEMIP	4.04e-04	17	25	2	MM14864
Pubmed	Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway.	MST1 MST1L	8.73e-07	2	33	2	29760744
Pubmed	Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3.	MST1 MST1L	8.73e-07	2	33	2	8393443
Pubmed	MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis.	MST1 MST1L	8.73e-07	2	33	2	27609031
Pubmed	Hepatocyte growth factor-like protein is required for prostate tumor growth in the TRAMP mouse model.	MST1 MST1L	8.73e-07	2	33	2	24980820
Pubmed	Mst1 deletion reduces hyperglycemia-mediated vascular dysfunction via attenuating mitochondrial fission and modulating the JNK signaling pathway.	MST1 MST1L	8.73e-07	2	33	2	31206688
Pubmed	Characterization of the effects of cross-linking of macrophage CD44 associated with increased phagocytosis of apoptotic PMN.	CD44 TIAM1	8.73e-07	2	33	2	22427969
Pubmed	Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein.	MST1 MST1L	8.73e-07	2	33	2	10728827
Pubmed	Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism.	MST1 MST1L	8.73e-07	2	33	2	16961763
Pubmed	Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice.	MST1 MST1L	8.73e-07	2	33	2	39253972
Pubmed	Cerebral ischemia-reperfusion is modulated by macrophage-stimulating 1 through the MAPK-ERK signaling pathway.	MST1 MST1L	8.73e-07	2	33	2	32017081
Pubmed	Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy.	MST1 MST1L	8.73e-07	2	33	2	30708325
Pubmed	Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.	MST1 MST1L	8.73e-07	2	33	2	24409221
Pubmed	Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1.	MST1 MST1L	8.73e-07	2	33	2	27696525
Pubmed	Hepatocyte-specific expression of the mouse hepatocyte growth factor-like protein.	MST1 MST1L	8.73e-07	2	33	2	8340069
Pubmed	Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice.	MST1 MST1L	8.73e-07	2	33	2	9486989
Pubmed	Treatment with XMU-MP-1 erases hyperglycaemic memory in hearts of diabetic mice.	MST1 MST1L	8.73e-07	2	33	2	33887258
Pubmed	CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration.	CD44 TIAM1	8.73e-07	2	33	2	10636882
Pubmed	HGFL supports mammary tumorigenesis by enhancing tumor cell intrinsic survival and influencing macrophage and T-cell responses.	MST1 MST1L	8.73e-07	2	33	2	25938541
Pubmed	The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse.	MST1 MST1L	2.62e-06	3	33	2	10225971
Pubmed	Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes.	MST1 MST1L	2.62e-06	3	33	2	38430683
Pubmed	Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons.	MST1 MST1L	2.62e-06	3	33	2	12538524
Pubmed	Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes.	MST1 MST1L	2.62e-06	3	33	2	19339990
Pubmed	TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1.	MST1 MST1L	2.62e-06	3	33	2	26698664
Pubmed	Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition.	MST1 MST1L	2.62e-06	3	33	2	30063115
Pubmed	Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury.	MST1 MST1L	2.62e-06	3	33	2	27218122
Pubmed	Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction.	MST1 MST1L	2.62e-06	3	33	2	17395874
Pubmed	Genetic deletion of Mst1 alters T cell function and protects against autoimmunity.	MST1 MST1L	2.62e-06	3	33	2	24852423
Pubmed	Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement.	MST1 MST1L	2.62e-06	3	33	2	27496379
Pubmed	Macrophage-stimulating protein cooperates with erythropoietin to induce colony formation and MAP kinase activation in primary erythroid progenitor cells.	MST1 MST1L	2.62e-06	3	33	2	12804176
Pubmed	Receptor tyrosine kinase Ron is expressed in mouse reproductive tissues during embryo implantation and is important in trophoblast cell function.	MST1 MST1L	2.62e-06	3	33	2	12606483
Pubmed	Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice.	MST1 MST1L	2.62e-06	3	33	2	36623453
Pubmed	Hippo Kinase MST1-Mediated Cell Metabolism Reprograms the Homeostasis and Differentiation of Granulocyte Progenitor Cells.	MST1 MST1L	2.62e-06	3	33	2	37184367
Pubmed	CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status.	MST1 MST1L	2.62e-06	3	33	2	38288506
Pubmed	The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues.	MST1 MST1L	2.62e-06	3	33	2	8545120
Pubmed	Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesis.	MST1 MST1L	2.62e-06	3	33	2	25049204
Pubmed	Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development.	MST1 MST1L	2.62e-06	3	33	2	1832957
Pubmed	Activation of pro-survival CaMK4β/CREB and pro-death MST1 signaling at early and late times during a mouse model of prion disease.	MST1 MST1L	2.62e-06	3	33	2	25183307
Pubmed	MST1 mediates neuronal loss and cognitive deficits: A novel therapeutic target for Alzheimer's disease.	MST1 MST1L	2.62e-06	3	33	2	35525373
Pubmed	MST1 coordinately regulates autophagy and apoptosis in diabetic cardiomyopathy in mice.	MST1 MST1L	2.62e-06	3	33	2	27510910
Pubmed	Combination of melatonin and irisin ameliorates lipopolysaccharide-induced cardiac dysfunction through suppressing the Mst1-JNK pathways.	MST1 MST1L	2.62e-06	3	33	2	31976559
Pubmed	Over-expressed MST1 impaired spatial memory via disturbing neural oscillation patterns in mice.	MST1 MST1L	2.62e-06	3	33	2	32468668
Pubmed	Nicorandil alleviates myocardial injury and post-infarction cardiac remodeling by inhibiting Mst1.	MST1 MST1L	2.62e-06	3	33	2	29127009
Pubmed	Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration.	MST1 MST1L	2.62e-06	3	33	2	27465533
Pubmed	Suramin protects hepatocytes from LPS-induced apoptosis by regulating mitochondrial stress and inactivating the JNK-Mst1 signaling pathway.	MST1 MST1L	2.62e-06	3	33	2	30771091
Pubmed	MST1 mediates the N-methyl-D-aspartate-induced excitotoxicity in mouse cortical neurons.	MST1 MST1L	2.62e-06	3	33	2	34967918
Pubmed	Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity.	MST1 MST1L	2.62e-06	3	33	2	38898027
Pubmed	WASP and Mst1 coregulate B-cell development and B-cell receptor signaling.	MST1 MST1L	2.62e-06	3	33	2	32045478
Pubmed	Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2.	MST1 MST1L	2.62e-06	3	33	2	27940445
Pubmed	Inhibition of TLR4-induced IκB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein.	MST1 MST1L	5.23e-06	4	33	2	21078906
Pubmed	MST1 controls murine neutrophil homeostasis via the G-CSFR/STAT3 axis.	MST1 MST1L	5.23e-06	4	33	2	36618429
Pubmed	Hyperglycemia-Induced Overexpression of PH Domain Leucine-Rich Repeat Protein Phosphatase 1 (PHLPP1) Compromises the Cardioprotective Effect of Ischemic Postconditioning Via Modulation of the Akt/Mst1 Pathway Signaling.	MST1 MST1L	5.23e-06	4	33	2	35715527
Pubmed	Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking.	MST1 MST1L	5.23e-06	4	33	2	25074980
Pubmed	OSM mitigates post-infarction cardiac remodeling and dysfunction by up-regulating autophagy through Mst1 suppression.	MST1 MST1L	5.23e-06	4	33	2	27825852
Pubmed	MST1 deficiency promotes B cell responses by CD4+ T cell-derived IL-4, resulting in hypergammaglobulinemia.	MST1 MST1L	5.23e-06	4	33	2	28527887
Pubmed	Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration.	MST1 MST1L	5.23e-06	4	33	2	25133611
Pubmed	LncRNA SNHG17 knockdown promotes Parkin-dependent mitophagy and reduces apoptosis of podocytes through Mst1.	MST1 MST1L	5.23e-06	4	33	2	32627655
Pubmed	Macrophage MST1/2 Disruption Impairs Post-Infarction Cardiac Repair via LTB4.	MST1 MST1L	5.23e-06	4	33	2	34515499
Pubmed	The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes.	MST1 MST1L	5.23e-06	4	33	2	22412158
Pubmed	Functional role of Mst1/Mst2 in embryonic stem cell differentiation.	MST1 MST1L	5.23e-06	4	33	2	24224013
Pubmed	Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice.	MST1 MST1L	5.23e-06	4	33	2	26903296
Pubmed	Glyceraldehyde-3-phosphate dehydrogenase interacts with proapoptotic kinase mst1 to promote cardiomyocyte apoptosis.	MST1 MST1L	5.23e-06	4	33	2	23527007
Pubmed	A cell-intrinsic role for Mst1 in regulating thymocyte egress.	MST1 MST1L	5.23e-06	4	33	2	19692642
Pubmed	Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling.	MST1 MST1L	5.23e-06	4	33	2	28480597
Pubmed	Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion.	MST1 MST1L	5.23e-06	4	33	2	16892067
Pubmed	Hippo signaling pathway reveals a spatio-temporal correlation with the size of primordial follicle pool in mice.	MST1 MST1L	5.23e-06	4	33	2	25659841
Pubmed	Mammalian Sterile 20-like Kinase 1 (Mst1) Enhances the Stability of Forkhead Box P3 (Foxp3) and the Function of Regulatory T Cells by Modulating Foxp3 Acetylation.	MST1 MST1L	5.23e-06	4	33	2	26538561
Pubmed	MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS.	MST1 MST1L	5.23e-06	4	33	2	23818595
Pubmed	RON (MST1R) and HGFL (MST1) Co-Overexpression Supports Breast Tumorigenesis through Autocrine and Paracrine Cellular Crosstalk.	MST1 MST1L	5.23e-06	4	33	2	35626096
Pubmed	Mammalian sterile 20-like kinase 1 suppresses lymphoma development by promoting faithful chromosome segregation.	MST1 MST1L	5.23e-06	4	33	2	22926556
Pubmed	Treatment with Mammalian Ste-20-like Kinase 1/2 (MST1/2) Inhibitor XMU-MP-1 Improves Glucose Tolerance in Streptozotocin-Induced Diabetes Mice.	MST1 MST1L	5.23e-06	4	33	2	32987643
Pubmed	The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development.	MST1 MST1L	5.23e-06	4	33	2	30386341
Pubmed	A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870.	MST1 MST1L	5.23e-06	4	33	2	27919044
Pubmed	Mst1/2 Kinases Modulate Glucose Uptake for Osteoblast Differentiation and Bone Formation.	MST1 MST1L	5.23e-06	4	33	2	29474739
Pubmed	mTORC2 regulates cardiac response to stress by inhibiting MST1.	MST1 MST1L	5.23e-06	4	33	2	25843706
Pubmed	The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module.	CD44 TIAM1	5.23e-06	4	33	2	19893486
Pubmed	Macrophage-stimulating protein, the ligand for the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase, inhibits IL-12 production by primary peritoneal macrophages stimulated with IFN-gamma and lipopolysaccharide.	MST1 MST1L	5.23e-06	4	33	2	14734766
Pubmed	Thioredoxin-1 functions as a molecular switch regulating the oxidative stress-induced activation of MST1.	MST1 MST1L	5.23e-06	4	33	2	23085515
Pubmed	Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus.	MST1 MST1L	8.72e-06	5	33	2	23033074
Pubmed	Assignment of the gene coding for hepatocyte growth factor-like protein to mouse chromosome 9.	MST1 MST1L	8.72e-06	5	33	2	1354648
Pubmed	Mst1 inhibits Sirt3 expression and contributes to diabetic cardiomyopathy through inhibiting Parkin-dependent mitophagy.	MST1 MST1L	8.72e-06	5	33	2	29674007
Pubmed	Tubule-Specific Mst1/2 Deficiency Induces CKD via YAP and Non-YAP Mechanisms.	MST1 MST1L	8.72e-06	5	33	2	32253273
Pubmed	Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver.	MST1 MST1L	8.72e-06	5	33	2	20080689
Pubmed	The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.	MST1 MST1L	8.72e-06	5	33	2	19073936
Pubmed	Mst1-Deficiency Induces Hyperactivation of Monocyte-Derived Dendritic Cells via Akt1/c-myc Pathway.	MST1 MST1L	8.72e-06	5	33	2	31572367
Pubmed	Mst1 attenuates myocardial ischemia/reperfusion injury following heterotopic heart transplantation in mice through regulating Keap1/Nrf2 axis.	MST1 MST1L	8.72e-06	5	33	2	36646002
Pubmed	A single transcription factor is sufficient to induce and maintain secretory cell architecture.	MST1 MST1L	8.72e-06	5	33	2	28174210
Pubmed	Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice.	MST1 MST1L	1.31e-05	6	33	2	19956688
Pubmed	cDNA cloning and chromosomal mapping of the mouse type VII collagen gene (Col7a1): evidence for rapid evolutionary divergence of the gene.	MST1 MST1L	1.31e-05	6	33	2	8325648
Pubmed	Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling.	MST1 MST1L	1.31e-05	6	33	2	21572393
Pubmed	Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson's disease.	MST1 MST1L	1.31e-05	6	33	2	32929029
Pubmed	Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL.	MST1 MST1L	1.31e-05	6	33	2	24813943
Pubmed	MT1-MMP-dependent neovessel formation within the confines of the three-dimensional extracellular matrix.	CD44 PLG	1.83e-05	7	33	2	15545316
Pubmed	MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane.	MST1 MST1L	1.83e-05	7	33	2	27701149
Pubmed	CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin.	CD44 TIAM1	1.83e-05	7	33	2	17702746
Pubmed	MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.	MST1 MST1L	1.83e-05	7	33	2	18328708
Pubmed	Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.	L3MBTL1 SSPOP DNMT1	3.42e-05	66	33	3	15790807
Pubmed	Exploiting Expression of Hippo Effector, Yap, for Expansion of Functional Islet Mass.	MST1 MST1L	3.91e-05	10	33	2	26378466
Pubmed	Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2.	MST1 MST1L	4.78e-05	11	33	2	24141421
Pubmed	Extra-embryonic-specific imprinted expression is restricted to defined lineages in the post-implantation embryo.	PLG DNMT1	6.77e-05	13	33	2	21354127
Pubmed	Fv2 encodes a truncated form of the Stk receptor tyrosine kinase.	MST1 MST1L	6.77e-05	13	33	2	10508511
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PHLDB3 TIAM1	2.15e-02	206	20	2	682
Coexpression	MIKKELSEN_IPS_ICP_WITH_H3K4ME3_AND_H327ME3	CD44 MST1 MST1L ISLR	2.25e-05	132	33	4	MM841
Coexpression	SABATES_COLORECTAL_ADENOMA_UP	CD44 SLC6A6 DMBT1 CEMIP	2.83e-05	140	33	4	M929
Coexpression	HU_GENOTOXIN_ACTION_DIRECT_VS_INDIRECT_24HR	MST1 MST1L HDAC6	5.35e-05	58	33	3	MM661
Coexpression	BROWNE_HCMV_INFECTION_18HR_DN	CD44 CA12 L3MBTL1 CEMIP	7.86e-05	182	33	4	M6641
Coexpression	NABA_ECM_GLYCOPROTEINS	OIT3 DMBT1 VWA7 SSPOP	9.48e-05	191	33	4	MM17059
Coexpression	NABA_ECM_GLYCOPROTEINS	OIT3 DMBT1 VWA7 SSPOP	1.05e-04	196	33	4	M3008
Coexpression	GSE10325_LUPUS_CD4_TCELL_VS_LUPUS_BCELL_UP	TRIM16 TIAM1 DNMT1 MAPKAPK3	1.11e-04	199	33	4	M3084
Coexpression	GSE9960_GRAM_POS_VS_GRAM_NEG_AND_POS_SEPSIS_PBMC_DN	CD44 GJA10 DMBT1 LRP10	1.13e-04	200	33	4	M7133
Coexpression	GSE15324_NAIVE_VS_ACTIVATED_CD8_TCELL_DN	CD44 CA12 SLC6A6 MAPKAPK3	1.13e-04	200	33	4	M3525
Coexpression	OZANNE_AP1_TARGETS_UP	CD44 DNMT1	1.39e-04	14	33	2	M15822
Coexpression	MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_DN	DNER CD44 CA12 CEMIP	2.10e-04	235	33	4	M2256
Coexpression	NABA_MATRISOME	MST1 MST1L OIT3 DMBT1 PLG VWA7 SSPOP	2.17e-04	1008	33	7	MM17056
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ISLR GPHA2 MRAP CEMIP	2.71e-06	132	33	4	893b7ec2a2d8a140cc98575d1beca1189f053e9a
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD44 KLK8 MST1 MAPKAPK3	5.96e-06	161	33	4	54eda81a570e422b35fcea799e640c7654122969
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD44 DMBT1 MRAP DNMT1	9.46e-06	181	33	4	9fce5eee75684a7ecac6996e26e9215bc95098b2
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD44 DMBT1 MRAP DNMT1	9.46e-06	181	33	4	ad97e802e934738ddece675232a72308db2da256
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KLK8 CA12 MST1 CEMIP	1.24e-05	194	33	4	79baee8b35b7707bbeb07c73b5e17b68bcd7bbc2
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibro-meso\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KLK8 CA12 MST1 CEMIP	1.24e-05	194	33	4	f6e348f1f35c526cad6c349f1fdd0bd92d18aa3c
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KLK8 CA12 MST1 CEMIP	1.24e-05	194	33	4	ce599ed0dc181aea0584e426636de5098f34ebe6
ToppCell	Biopsy_Control_(H.)-Mesenchymal-Mesothelial_cells\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	KLK8 CA12 MST1 CEMIP	1.37e-05	199	33	4	ca970114b5aef4518ce580897a62ac88688b2671
ToppCell	Parenchyma_COVID-19-Stromal-TX-Mesothelial-1\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	KLK8 CA12 MST1 CEMIP	1.40e-05	200	33	4	bf50e30d5cafb71c567e89580f62084d2f894170
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Mesothelial-1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KLK8 CA12 MST1 CEMIP	1.40e-05	200	33	4	5e5ad07679d5dd2ca80249bce9aaf4a95d42187b
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Mesothelial-1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	KLK8 CA12 MST1 CEMIP	1.40e-05	200	33	4	c800f20adedf4ca736c740510889e92d8bf0ba44
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	GPHA2 MRAP CEMIP	6.22e-05	104	33	3	424a58b04c8b5108b70f15d8353c8e4b9db1e730
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Mgp_(Mgp)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	GPHA2 MRAP CEMIP	6.22e-05	104	33	3	11d91471b6c4fa6b00a91d9fd4db72ee60d1f801
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Mgp_(Mgp)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	GPHA2 MRAP CEMIP	6.22e-05	104	33	3	9b05ae514437eb0c8b1b23607ae8cbc371ffa85b
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_2-Endothelial_Tip.Dcn.1500015O10Rik_(1500015O10Rik)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	OIT3 GPHA2 MRAP	8.18e-05	114	33	3	c3feca81edee445cbe5e46a07e1a59327dc2e981
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_2-Endothelial_Tip.Dcn.1500015O10Rik_(1500015O10Rik)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	OIT3 GPHA2 MRAP	8.18e-05	114	33	3	89350483d2ce57afc612fe25398e35af121d50f0
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ISLR MRAP CEMIP	1.26e-04	132	33	3	560e836764ed7806fb18282dfebe434d30112a9a
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	OIT3 GPHA2 MRAP	1.35e-04	135	33	3	4451c44f3ad788437f4e2ae81049fbbab53f967e
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	OIT3 GPHA2 MRAP	1.35e-04	135	33	3	45f67f33c8320d9fb6dbceae603b564f6a8ffd1e
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_ALM_Tgfb1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KLK8 CA12 ISLR	1.67e-04	145	33	3	84d50a13b48d50c16e768422908e371a55972d0e
ToppCell	kidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 PLG CUBN	1.67e-04	145	33	3	47a3bb973a508d3097213a2d86ad1ce697af9bae
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-regulatory_T_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MST1 TIAM1 MAP3K14	1.70e-04	146	33	3	7748277cf2f12e2930d4f5a22247ab9bc266a954
ToppCell	PND28-Immune-Immune_Myeloid-Granulocytic-Basophil\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PHLDB3 OIT3 HDAC6	2.11e-04	157	33	3	8c42af7aa1f1b6f4fe2f8d00a8b4a800f121e804
ToppCell	PND28-Immune-Immune_Myeloid-Granulocytic\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PHLDB3 OIT3 HDAC6	2.11e-04	157	33	3	ee1be3c756b72fceac6b4ccb416dd4bd031a2193
ToppCell	PND28-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PHLDB3 OIT3 HDAC6	2.11e-04	157	33	3	008f938a338f43c3251dcac574f1b4f689926c71
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Epithelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJA10 DMBT1 VWA7	2.15e-04	158	33	3	12661763d1c309106801cb710c04cd2b62d16cba
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Epithelial-TECs\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJA10 DMBT1 VWA7	2.15e-04	158	33	3	0792c39e6fc0745095af7812de2d50949540d60f
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_IT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KLK8 CA12 ISLR	2.15e-04	158	33	3	9e0589f770920f8ac41cfe5cd0a29e9e7a04a308
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Epithelial-epithelial_cell_of_thymus\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJA10 DMBT1 VWA7	2.15e-04	158	33	3	e7db50d6dfaf7280a73a0d5b5aa4f43ea2762d72
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ISLR MRAP CEMIP	2.19e-04	159	33	3	cb2470b288c13e454a2a80115b0d5613b3f718e6
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_ALM_Oprk1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KLK8 CA12 ISLR	2.31e-04	162	33	3	2d28306c6125b31f11ea6d911a167b93a74907c5
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CORO1B TIAM1 CEMIP	2.35e-04	163	33	3	bca9abd02ffb2a90c8386a59f5e25126ae7b6acd
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ISLR RPTOR MAP3K14	2.39e-04	164	33	3	d167c7a987b9b35d1e7725c803df4f9cd5380e47
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-Tregs\|bone_marrow / Manually curated celltypes from each tissue	TRIM16 CORO1B TIAM1	2.44e-04	165	33	3	1ae1ad4e1fe19b6eefff0f9a03d58a384f169759
ToppCell	mild-Lymphocytic-CD4_T_cells_3\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CD44 CORO1B TIAM1	2.48e-04	166	33	3	f8f8423423d72f0ea0266b59126abb27beb23094
ToppCell	droplet-Limb_Muscle-nan-3m-Myeloid-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OIT3 GPHA2 MAP3K14	2.48e-04	166	33	3	35db3022c33d6f8bb6587d9eec89a7cccb70271a
ToppCell	facs-Large_Intestine-Proximal\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD44 CA12 DMBT1	2.57e-04	168	33	3	23e0e1592d7400012d289adb10c7598285bae2e9
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	L3MBTL1 CUBN TIAM1	2.57e-04	168	33	3	ca94b29c1030484143a77f2df06dad74d2c6136e
ToppCell	droplet-Lung-nan-3m-Myeloid-basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OIT3 PLG MAPKAPK3	2.61e-04	169	33	3	da607c1d068038d5a3d1117f6aa6e4c6f3552e97
ToppCell	droplet-Lung-nan-3m-Myeloid-Basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OIT3 PLG MAPKAPK3	2.61e-04	169	33	3	a14b46231e079a0fd9f3ca13d5d48113be76fd0f
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DNER CA12 MST1L	2.80e-04	173	33	3	0c74bdb40e635d906fd180412c23bf7fed61621e
ToppCell	droplet-Lung-3m-Hematologic-myeloid-Basophil/Mast_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OIT3 PLG MAPKAPK3	2.80e-04	173	33	3	b2c55084ef6dac0e329c2e65c24cfe0045859c30
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD44 CA12 DMBT1	2.80e-04	173	33	3	e1378201b15ffb98e196ac39fe3ee4b4078953bd
ToppCell	droplet-Lung-3m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OIT3 PLG MAPKAPK3	2.80e-04	173	33	3	120dd20e8a71f9169a1596b6171df7aa0b96dd15
ToppCell	control-Lymphocytic-CD4_T_cells_3\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CORO1B MRAP CEMIP	2.80e-04	173	33	3	0c9fb18536ddd61b51b7bb4d40841f67b017f360
ToppCell	facs-Large_Intestine-Proximal-3m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD44 CA12 DMBT1	2.80e-04	173	33	3	99532bb768ee35fed939a377acb5215d3f8904bd
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MST1 PLG CUBN	2.95e-04	176	33	3	1595dbeee336a81e581325d63208ec6262664ee9
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-nan\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD44 CA12 DMBT1	2.95e-04	176	33	3	1dd54bfaa58541de51e5a8328651d390833bd480
ToppCell	droplet-Tongue-nan-24m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD44 KLK8 TIAM1	2.95e-04	176	33	3	9739b0653c511ab017507a0c7ee4f6d7082e87db
ToppCell	droplet-Kidney-nan-21m-Lymphocytic-CD45____plasma_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD44 L3MBTL1 SSPOP	2.99e-04	177	33	3	41cbb2c109eaa7be366fc0510cce64abc06837b4
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MST1 PLG CUBN	2.99e-04	177	33	3	2f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCell	droplet-Limb_Muscle-nan-24m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CA12 SSPOP ZNF316	3.04e-04	178	33	3	f2002a5c4758d0af6c1880ca12f0af0d5e8888e4
ToppCell	facs-Pancreas-Endocrine-24m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ISLR TIAM1 MRAP	3.09e-04	179	33	3	6f51a4580c06fc55cc764052c9b26f7c55660282
ToppCell	facs-Pancreas-Endocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ISLR TIAM1 MRAP	3.09e-04	179	33	3	a6ce1fa338d4905bd6afef00763ac83e916a0b37
ToppCell	facs-Pancreas-Endocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ISLR TIAM1 MRAP	3.09e-04	179	33	3	f14440f6ce9b4fcdd4bcb2488b949f9a0e17bc23
ToppCell	IPF-Epithelial-Mesothelial\|IPF / Disease state, Lineage and Cell class	KLK8 CA12 MST1	3.15e-04	180	33	3	1fa54bf4dba72866b2295639d991af639341bc08
ToppCell	368C-Lymphocytic-ILC-ILC-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CUBN ARMC5 ZNF316	3.15e-04	180	33	3	eb5a57604c7f2ad256c300085dbf5069d0ae1ad0
ToppCell	368C-Lymphocytic-ILC\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CUBN ARMC5 ZNF316	3.15e-04	180	33	3	ddba4dc3bbcfe4e4a22400be73bbc62d3ff27d3c
ToppCell	(2)_NK/T-(230)_CD4+/CD25+_Reg_T_cell\|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)	CD44 TRIM16 CORO1B	3.20e-04	181	33	3	ad14c7111d4fb924afd233cb114447f195373a7c
ToppCell	COVID-19-kidney-Stressed_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CA12 PLG CUBN	3.20e-04	181	33	3	6980ea624151da32b7f537f263e40fcb87a02e81
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MST1 PLG CUBN	3.25e-04	182	33	3	4a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MST1 PLG CUBN	3.30e-04	183	33	3	85446581999cd66b171c4f69b7eb8b0bbbaa8617
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PLG HDAC6 CUBN	3.30e-04	183	33	3	facd6dbe0851b537d70a899ac7485714ab27d071
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MST1 PLG CUBN	3.30e-04	183	33	3	84b64cf728629c3af9a8d2ed15b93adf562c54b8
ToppCell	IPF-Epithelial-Mesothelial\|World / Disease state, Lineage and Cell class	KLK8 CA12 MST1	3.30e-04	183	33	3	7df20e3172a1220ff427f30181f4f0c3b7fe2d42
ToppCell	facs-Liver-Non-hepatocytes-3m-Lymphocytic-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CA12 MAPKAPK3	3.35e-04	184	33	3	8fc047977fad38fcd26eebcc279a688efd342ed8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MST1 PLG CUBN	3.35e-04	184	33	3	9434731f651820b05335085582960f08fbf895de
ToppCell	COVID-19-kidney-Mito-rich_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CA12 PLG CUBN	3.41e-04	185	33	3	1bbc2ba8a20f72f61981b1301cdd6018cdd9150d
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-maDC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PHLDB3 TIAM1 MAP3K14	3.41e-04	185	33	3	7e3d9f5050e71e91021245c11101e994ae41d22b
ToppCell	COPD-Epithelial-Mesothelial\|World / Disease state, Lineage and Cell class	KLK8 CA12 MST1	3.41e-04	185	33	3	23579988036fc1925992c31919750f9b3fe9f790
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_1\|390C / Donor, Lineage, Cell class and subclass (all cells)	MST1 TIAM1 LRP10	3.46e-04	186	33	3	064b6047215597465bb51a8a1547ef5a226552f9
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD44 DMBT1 DNMT1	3.46e-04	186	33	3	4ed1b97e2552f3c4134f25665d7513498ffac16c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MST1 PLG CUBN	3.46e-04	186	33	3	a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD44 DMBT1 DNMT1	3.46e-04	186	33	3	15ab6666748a641226e42e6ca6eeaf186a501c95
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A6 PLG CUBN	3.46e-04	186	33	3	b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_1-Mesothelial\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KLK8 MST1 CEMIP	3.46e-04	186	33	3	7812ed80d2378aca9957ef22fc3c8fb7fb58434b
ToppCell	Control-Myeloid-DC_Mature\|Control / Disease state, Lineage and Cell class	PHLDB3 TIAM1 MAP3K14	3.52e-04	187	33	3	049780ca2a3e6adcd89dc2cf3095b5ad068b244a
ToppCell	Control-Myeloid-DC_Mature\|World / Disease state, Lineage and Cell class	PHLDB3 TIAM1 MAP3K14	3.52e-04	187	33	3	51bfc450e78284796b02317e91830357850b5437
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium-Mesothelium_L.2.6.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KLK8 CA12 MST1	3.57e-04	188	33	3	e2bee29865805d4db30b090d4bce9a1f5311cf51
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MST1 TIAM1 LRP10	3.57e-04	188	33	3	b1ec7c45aedcc3d22cac898c6a3679e7f8b44c77
ToppCell	COPD-Epithelial-Mesothelial\|COPD / Disease state, Lineage and Cell class	KLK8 CA12 MST1	3.63e-04	189	33	3	79bb2593ad5d17f94b17972884241f03a0f43770
ToppCell	facs-Skin-Anagen\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD44 SLC6A6 LRP10	3.63e-04	189	33	3	adbfc723130079b4caf551f66d2aee86fab1903c
ToppCell	COVID-19_Mild-Treg\|COVID-19_Mild / Disease condition and Cell class	TRIM16 CORO1B TIAM1	3.63e-04	189	33	3	f0fceb5f87ca260bfe038c0db3487a6d2e1b0a6e
ToppCell	IPF-Epithelial-Basal\|Epithelial / Disease state, Lineage and Cell class	CD44 TIAM1 CEMIP	3.68e-04	190	33	3	4f15842b424eefadbfe451875e517cf70e29607f
ToppCell	facs-Skin-Anagen-3m-Epithelial\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD44 SLC6A6 LRP10	3.68e-04	190	33	3	888ded899f0513d41bf655896d59ae8ef74e0978
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CD44 CA12 CEMIP	3.68e-04	190	33	3	ad0d9aed8c9c99551765d14730d70ebef1ea856b
ToppCell	droplet-Skin-nan-21m-Epithelial-basal_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CA12 SLC6A6 GPHA2	3.68e-04	190	33	3	c1bfc1960a3df49c0f459454a7363804c32418ee
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Radial_glial-RGCs_early_2\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	CD44 LRP10 MAPKAPK3	3.74e-04	191	33	3	06107849463a1ccb78a5ccd3ae31619ef6bedda3
ToppCell	COVID-19_Severe-Treg\|COVID-19_Severe / Disease condition and Cell class	CD44 TRIM16 CORO1B	3.74e-04	191	33	3	06fdd76ea13b93e29959c745698b57af6746aaeb
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DNER CA12 MST1L	3.80e-04	192	33	3	8769b67d1cad1be65da3938f916e5bf88f88f6b8
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CD44 ISLR CEMIP	3.80e-04	192	33	3	41a8326cd5bc19ad5041068501bab4c72399222e
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DNER CA12 MST1L	3.80e-04	192	33	3	7af2b5240b1fad2177d8022e5f4fc1fe9e8f03b5
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D175\|Adult / Lineage, Cell type, age group and donor	CD44 SLC6A6 TIAM1	3.80e-04	192	33	3	733491e932350e3c216a626cc49c3cd3fe970a82
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CD44 ISLR CEMIP	3.80e-04	192	33	3	f88aba74d6e8c594c32fe2bc095b5da28b4b28e9
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-Tregs\|lymph-node_spleen / Manually curated celltypes from each tissue	CD44 CORO1B TIAM1	3.80e-04	192	33	3	91a4d06e8d1d1fe2ce5f72668108513bd2a72c4d
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DNER CA12 MST1L	3.80e-04	192	33	3	32e4a180037e516c5cc798cd9dada9385e0f43ae
ToppCell	Control-Treg\|Control / Disease group and Cell class	CD44 CORO1B MAPKAPK3	3.80e-04	192	33	3	3a9a8ac2aa278adde848608f9bb92a002dbb9bcc
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MST1 PLG CUBN	3.80e-04	192	33	3	3e1a4cb0d83efd502c8613d41a1692bdda5860ed
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-T_cells-Treg\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD44 CORO1B MAPKAPK3	3.80e-04	192	33	3	b7e08cadb50f66c2efdde45e0fa8bab29367269b
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DNER CA12 MST1L	3.80e-04	192	33	3	46ea8f4f292db70420b378c6fa3e55e99413679c
Disease	inflammatory bowel disease (implicated_via_orthology)	MST1 MST1L	3.58e-04	25	33	2	DOID:0050589 (implicated_via_orthology)
Disease	psychosis predisposition measurement	CNOT6 CD44	3.88e-04	26	33	2	EFO_0008337
Disease	lung cancer (is_marker_for)	CA12 DNMT1	8.76e-04	39	33	2	DOID:1324 (is_marker_for)
Disease	melanoma	HDAC6 CUBN GPHA2	2.66e-03	248	33	3	C0025202
Disease	urate measurement	CA12 ISLR GJA10 CUBN CEMIP	2.98e-03	895	33	5	EFO_0004531
Disease	pentachlorophenol measurement	DNER RPTOR	3.03e-03	73	33	2	EFO_0022071
Disease	parathion measurement	DNER RPTOR	3.03e-03	73	33	2	EFO_0022070
Disease	potassium chromate measurement	DNER RPTOR	3.03e-03	73	33	2	EFO_0022072
Disease	mercuric chloride measurement	DNER RPTOR	3.03e-03	73	33	2	EFO_0022068
Disease	heptachlor epoxide measurement	DNER RPTOR	3.03e-03	73	33	2	EFO_0022067
Disease	methoxychlor measurement	DNER RPTOR	3.03e-03	73	33	2	EFO_0022069
Disease	4,6-dinitro-o-cresol measurement	DNER RPTOR	3.03e-03	73	33	2	EFO_0022053
Disease	2,4,5-trichlorophenol measurement	DNER RPTOR	3.03e-03	73	33	2	EFO_0022052
Disease	azinphos methyl measurement	DNER RPTOR	3.03e-03	73	33	2	EFO_0022055
Disease	aldrin measurement	DNER RPTOR	3.03e-03	73	33	2	EFO_0022054
Disease	dicofol measurement	DNER RPTOR	3.03e-03	73	33	2	EFO_0022060
Disease	disulfoton measurement	DNER RPTOR	3.03e-03	73	33	2	EFO_0022062
Disease	dieldrin measurement	DNER RPTOR	3.03e-03	73	33	2	EFO_0022061
Disease	endrin measurement	DNER RPTOR	3.03e-03	73	33	2	EFO_0022064
Disease	endosulfan measurement	DNER RPTOR	3.03e-03	73	33	2	EFO_0022063
Disease	heptachlor measurement	DNER RPTOR	3.03e-03	73	33	2	EFO_0022066
Disease	ethion measurement	DNER RPTOR	3.03e-03	73	33	2	EFO_0022065

Protein segments in the cluster

Peptide	Gene	Start	Entry
IPWCLPHTGNRHNHW	DNMT1	1496	P26358
DQHSGQLHVHSPCPW	GJA10	326	Q969M2
HTGPVLDIDWCPHND	CORO1B	81	Q9BR76
SPGAAWPVLHHLHGC	ARMC5	796	Q96C12
PELQPWNPGHDQDHH	CEMIP	41	Q8WUJ3
EGWGHNPENCPHVQV	PHLDB3	516	Q6NSJ2
HPQSCHWLLDPHDGR	LRP10	216	Q7Z4F1
DHHWQASGGPHIVCI	MAPKAPK3	86	Q16644
ECQRWDLQHPHQHPF	MST1L	181	Q2TV78
TQLHLHWGNPNDPHG	CA12	116	O43570
HCDVDGQPAPQLHWH	ISLR	256	O14498
CHDFWVNANSPDIHP	L3MBTL1	346	Q9Y468
PENHCGTHAPVWLNG	OIT3	76	Q8WWZ8
WADRHPGGHQVLNHC	FADS2B	86	A8MWK0
NHPHNYPPHADCIWI	CUBN	2236	O60494
EGNWNPEAHPPLIHH	CD44	356	P16070
AWGQEAVIPGCHLHP	GPHA2	21	Q96T91
GHECQPHSQPWQAAL	KLK8	36	O60259
NHCNLWDSHHPEVPQ	HDAC6	491	Q9UBN7
ECQRWDLQHPHQHPF	MST1	211	P26927
GVPCQRWDAQIPHQH	MST1	301	P26927
HCPHGWVGANCEIHL	DNER	606	Q8NFT8
CPNNGWLSHNCGHHE	DMBT1	681	Q9UGM3
CPHNGWLSHNCQHSE	DMBT1	941	Q9UGM3
PHNGWLSHNCGHHED	DMBT1	1331	Q9UGM3
HHWLVENNISGCPHP	CNOT6	511	Q9ULM6
LNHVWKLHHPQDGGP	MAP3K14	236	Q99558
ELPWAHCNHSWNTPH	SLC6A6	156	P31641
PTCHEQHPEPGWHCQ	SSPOP	1291	A2VEC9
SPKHHQTCPWSHGLN	MRAP	71	Q8TCY5
PCQDWAAQEPHRHSI	PLG	501	P00747
VGAISCLAFHPHWPH	RPTOR	1301	Q8N122
CLAFHPHWPHLAVGS	RPTOR	1306	Q8N122
LPNVHQHNPDCDIWV	TIAM1	746	Q13009
HQWAHAEEKPHRCPD	ZNF316	821	A6NFI3
EPVKDHNWRYCPAHH	TRIM16	121	O95361
HSNWVELGEQQPHPH	VWA7	176	Q9Y334
IGFAPHFPHWFCNHH	nan	76	Q8TCH9