Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontubulin binding

CEP350 TUBGCP6 KIF21B CCSAP CCDC66 FHDC1 INO80 MAP4K4 TBCC TUBGCP3

3.01e-084284510GO:0015631
GeneOntologyMolecularFunctionmicrotubule binding

CEP350 TUBGCP6 KIF21B CCSAP CCDC66 FHDC1 MAP4K4 TUBGCP3

3.84e-07308458GO:0008017
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

SMARCA4 CHD9 CHD8 INO80

1.41e-0637454GO:0140658
GeneOntologyMolecularFunctionnuclear import signal receptor activity

KPNA5 KPNA6 KPNA1

1.19e-0520453GO:0061608
GeneOntologyMolecularFunctionnuclear localization sequence binding

KPNA5 KPNA6 KPNA1

3.01e-0527453GO:0008139
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

SMARCA4 KIF21B CHD9 CHD8 INO80 DDX55 SLFN13 TBCC BMS1

4.81e-05775459GO:0017111
GeneOntologyMolecularFunctionnucleocytoplasmic carrier activity

KPNA5 KPNA6 KPNA1

5.07e-0532453GO:0140142
GeneOntologyMolecularFunctionATP hydrolysis activity

SMARCA4 KIF21B CHD9 CHD8 INO80 DDX55 SLFN13

5.37e-05441457GO:0016887
GeneOntologyMolecularFunctionpyrophosphatase activity

SMARCA4 KIF21B CHD9 CHD8 INO80 DDX55 SLFN13 TBCC BMS1

8.87e-05839459GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

SMARCA4 KIF21B CHD9 CHD8 INO80 DDX55 SLFN13 TBCC BMS1

8.95e-05840459GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

SMARCA4 KIF21B CHD9 CHD8 INO80 DDX55 SLFN13 TBCC BMS1

8.95e-05840459GO:0016818
GeneOntologyMolecularFunctioncytoskeletal protein binding

CEP350 TUBGCP6 KIF21B CCSAP CCDC66 FHDC1 INO80 MAP4K4 TBCC TUBGCP3

1.34e-0410994510GO:0008092
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

SMARCA4 CHD9 CHD8 INO80

1.90e-04127454GO:0008094
GeneOntologyMolecularFunctionsignal sequence binding

KPNA5 KPNA6 KPNA1

2.06e-0451453GO:0005048
GeneOntologyMolecularFunctionATP-dependent activity

SMARCA4 KIF21B CHD9 CHD8 INO80 DDX55 SLFN13

4.13e-04614457GO:0140657
GeneOntologyMolecularFunctionhelicase activity

SMARCA4 CHD9 CHD8 DDX55

4.37e-04158454GO:0004386
GeneOntologyMolecularFunctionmicrotubule minus-end binding

TUBGCP6 TUBGCP3

5.12e-0415452GO:0051011
GeneOntologyMolecularFunctionG protein-coupled serotonin receptor activity

HTR2C CHRM3

1.11e-0322452GO:0004993
GeneOntologyMolecularFunctionneurotransmitter receptor activity

HTR2C CHRM3 GLRA2

1.48e-03100453GO:0030594
GeneOntologyMolecularFunctionmolecular carrier activity

KPNA5 KPNA6 KPNA1

1.85e-03108453GO:0140104
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

SMARCA4 CHD9 CHD8 INO80

2.83e-03262454GO:0140097
GeneOntologyMolecularFunctionhistone binding

SMARCA4 CHD8 KDM4A INO80

2.95e-03265454GO:0042393
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

SMARCA4 CHD9 CHD8 INO80 DDX55 SLFN13

3.09e-03645456GO:0140640
GeneOntologyMolecularFunctiongamma-tubulin binding

TUBGCP6 TUBGCP3

3.32e-0338452GO:0043015
GeneOntologyMolecularFunctionG protein-coupled amine receptor activity

HTR2C CHRM3

3.85e-0341452GO:0008227
GeneOntologyBiologicalProcessNLS-bearing protein import into nucleus

KPNA5 KPNA6 KPNA1

8.74e-0620423GO:0006607
GeneOntologyCellularComponentNLS-dependent protein nuclear import complex

KPNA5 KPNA6 KPNA1

1.03e-0610443GO:0042564
GeneOntologyCellularComponentnucleocytoplasmic transport complex

KPNA5 KPNA6 KPNA1

1.89e-0612443GO:0031074
GeneOntologyCellularComponentmicrotubule

TUBGCP6 KIF21B CCSAP CCDC66 FHDC1 INO80 TBCC TUBGCP3

1.34e-05533448GO:0005874
GeneOntologyCellularComponentequatorial microtubule organizing center

TUBGCP6 TUBGCP3

4.31e-055442GO:0000923
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

TUBGCP6 KIF21B CCSAP CCDC66 FHDC1 INO80 TBCC TUBGCP3

5.07e-04899448GO:0099513
GeneOntologyCellularComponentciliary transition zone

CCSAP CCDC66 TBCC

6.62e-0481443GO:0035869
GeneOntologyCellularComponentsupramolecular fiber

TUBGCP6 KIF21B CCSAP CCDC66 FHDC1 INO80 SCN1A TBCC TUBGCP3

6.62e-041179449GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

TUBGCP6 KIF21B CCSAP CCDC66 FHDC1 INO80 SCN1A TBCC TUBGCP3

6.95e-041187449GO:0099081
GeneOntologyCellularComponentgamma-tubulin complex

TUBGCP6 TUBGCP3

8.86e-0421442GO:0000930
MousePhenoincreased grooming behavior

ZNF462 CHD8 HTR2C SCN1A

3.75e-0574364MP:0001441
DomainBRK

SMARCA4 CHD9 CHD8

2.60e-076453SM00592
DomainBRK_domain

SMARCA4 CHD9 CHD8

2.60e-076453IPR006576
DomainBRK

SMARCA4 CHD9 CHD8

2.60e-076453PF07533
DomainArm_3

KPNA5 KPNA6 KPNA1

4.54e-077453PF16186
DomainImporting_su_alpha

KPNA5 KPNA6 KPNA1

4.54e-077453IPR024931
DomainArm_3

KPNA5 KPNA6 KPNA1

4.54e-077453IPR032413
DomainIBB

KPNA5 KPNA6 KPNA1

4.54e-077453PF01749
DomainIBB

KPNA5 KPNA6 KPNA1

7.26e-078453PS51214
DomainSNF2_N

SMARCA4 CHD9 CHD8 INO80

1.01e-0632454PF00176
DomainSNF2_N

SMARCA4 CHD9 CHD8 INO80

1.01e-0632454IPR000330
DomainImportin-a_IBB

KPNA5 KPNA6 KPNA1

1.09e-069453IPR002652
DomainHelicase_C

SMARCA4 CHD9 CHD8 INO80 DDX55

5.72e-06107455PF00271
DomainHELICc

SMARCA4 CHD9 CHD8 INO80 DDX55

5.72e-06107455SM00490
DomainHelicase_C

SMARCA4 CHD9 CHD8 INO80 DDX55

5.99e-06108455IPR001650
DomainHELICASE_CTER

SMARCA4 CHD9 CHD8 INO80 DDX55

6.26e-06109455PS51194
DomainHELICASE_ATP_BIND_1

SMARCA4 CHD9 CHD8 INO80 DDX55

6.26e-06109455PS51192
DomainDEXDc

SMARCA4 CHD9 CHD8 INO80 DDX55

6.26e-06109455SM00487
DomainHelicase_ATP-bd

SMARCA4 CHD9 CHD8 INO80 DDX55

6.55e-06110455IPR014001
DomainArm

KPNA5 KPNA6 KPNA1

5.60e-0531453PF00514
DomainGCP

TUBGCP6 TUBGCP3

5.65e-055452IPR007259
DomainSpc97_Spc98

TUBGCP6 TUBGCP3

5.65e-055452PF04130
DomainARM

KPNA5 KPNA6 KPNA1

1.21e-0440453SM00185
DomainARM_REPEAT

KPNA5 KPNA6 KPNA1

1.21e-0440453PS50176
DomainP-loop_NTPase

SMARCA4 KIF21B CHD9 CHD8 INO80 LRRIQ1 DDX55 SLFN13 BMS1

1.60e-04848459IPR027417
DomainArmadillo

KPNA5 KPNA6 KPNA1

1.97e-0447453IPR000225
DomainCNH

MAP4K4 MINK1

5.07e-0414452SM00036
DomainCNH

MAP4K4 MINK1

5.84e-0415452PS50219
DomainCNH_dom

MAP4K4 MINK1

5.84e-0415452IPR001180
DomainCNH

MAP4K4 MINK1

5.84e-0415452PF00780
DomainChromo_domain

CHD9 CHD8

1.51e-0324452IPR023780
DomainChromo

CHD9 CHD8

1.78e-0326452PF00385
DomainBromodomain_CS

SMARCA4 BRWD1

1.78e-0326452IPR018359
Domain-

SMARCA4 CHD9 CHD8 INO80 DDX55 SLFN13 BMS1

1.90e-037464573.40.50.300
DomainCHROMO_2

CHD9 CHD8

2.06e-0328452PS50013
DomainCHROMO_1

CHD9 CHD8

2.06e-0328452PS00598
DomainChromodomain-like

CHD9 CHD8

2.69e-0332452IPR016197
DomainCHROMO

CHD9 CHD8

2.86e-0333452SM00298
DomainChromo/shadow_dom

CHD9 CHD8

2.86e-0333452IPR000953
DomainBROMODOMAIN_1

SMARCA4 BRWD1

3.58e-0337452PS00633
DomainBromodomain

SMARCA4 BRWD1

3.78e-0338452PF00439
DomainBROMODOMAIN_2

SMARCA4 BRWD1

4.38e-0341452PS50014
DomainWD_REPEATS_1

KIF21B WDR4 PALB2 BRWD1

4.43e-03278454PS00678
DomainWD_REPEATS_2

KIF21B WDR4 PALB2 BRWD1

4.49e-03279454PS50082
DomainWD_REPEATS_REGION

KIF21B WDR4 PALB2 BRWD1

4.49e-03279454PS50294
DomainBROMO

SMARCA4 BRWD1

4.60e-0342452SM00297
DomainBromodomain

SMARCA4 BRWD1

4.60e-0342452IPR001487
Domain-

SMARCA4 BRWD1

4.60e-03424521.20.920.10
DomainWD40_repeat_dom

KIF21B WDR4 PALB2 BRWD1

5.59e-03297454IPR017986
PathwayREACTOME_ASSEMBLY_OF_THE_ORC_COMPLEX_AT_THE_ORIGIN_OF_REPLICATION

KPNA6 KPNA1

1.89e-049332MM15358
PathwayWP_15Q112_COPY_NUMBER_VARIATION_SYNDROME

TUBGCP6 TUBGCP3

1.89e-049332M39879
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

ZNF462 SMARCA4 RPL24 CHD9 EIF3D INO80 DDX55 AKAP17A MAP4K4 CCDC86 ARGLU1 TUBGCP3 BMS1

9.35e-101082461338697112
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

ZNF462 SMARCA4 CHD9 CHD8 KDM4A INO80 DDX55 CCDC86 KPNA1 BRWD1

5.73e-09608461036089195
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

CEP350 SMARCA4 CHD9 KPNA6 KDM4A ANKRD36 EIF3D WDR4 AKAP17A MAP4K4 ARGLU1 KPNA1 BRWD1

7.36e-091285461335914814
Pubmed

Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite.

KPNA5 KPNA6 KPNA1

2.16e-08546317981117
Pubmed

Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import.

KPNA5 KPNA6 KPNA1

4.32e-0864638551560
Pubmed

p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells.

KPNA5 KPNA6 KPNA1

4.32e-0864632064827
Pubmed

A synthetic peptide bearing the HIV-1 integrase 161-173 amino acid residues mediates active nuclear import and binding to importin alpha: characterization of a functional nuclear localization signal.

KPNA5 KPNA6 KPNA1

4.32e-08646315037073
Pubmed

Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation.

KPNA5 KPNA6 KPNA1

4.32e-0864638876228
Pubmed

Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection.

KPNA5 KPNA6 KPNA1

4.32e-0864637745752
Pubmed

HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator.

KPNA5 KPNA6 KPNA1

4.32e-0864637859280
Pubmed

Backbone cyclic peptide, which mimics the nuclear localization signal of human immunodeficiency virus type 1 matrix protein, inhibits nuclear import and virus production in nondividing cells.

KPNA5 KPNA6 KPNA1

4.32e-0864639548947
Pubmed

Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention.

KPNA5 KPNA6 KPNA1

4.32e-0864638529100
Pubmed

Evidence for direct association of Vpr and matrix protein p17 within the HIV-1 virion.

KPNA5 KPNA6 KPNA1

4.32e-0864638659115
Pubmed

The putative alpha helix 2 of human immunodeficiency virus type 1 Vpr contains a determinant which is responsible for the nuclear translocation of proviral DNA in growth-arrested cells.

KPNA5 KPNA6 KPNA1

4.32e-0864639557700
Pubmed

A role for human immunodeficiency virus type 1 Vpr during infection of peripheral blood mononuclear cells.

KPNA5 KPNA6 KPNA1

4.32e-0864639603322
Pubmed

CNI-H0294, a nuclear importation inhibitor of the human immunodeficiency virus type 1 genome, abrogates virus replication in infected activated peripheral blood mononuclear cells.

KPNA5 KPNA6 KPNA1

4.32e-0864639593140
Pubmed

HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase.

KPNA5 KPNA6 KPNA1

4.32e-0864637585960
Pubmed

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

KPNA5 KPNA6 KPNA1

4.32e-0864638041786
Pubmed

The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes.

KPNA5 KPNA6 KPNA1

4.32e-0864638041734
Pubmed

HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import.

KPNA5 KPNA6 KPNA1

4.32e-0864639303297
Pubmed

Inhibition of nuclear import by backbone cyclic peptidomimetics derived from the HIV-1 MA NLS sequence.

KPNA5 KPNA6 KPNA1

4.32e-08646311904219
Pubmed

Phenotype of HIV-1 lacking a functional nuclear localization signal in matrix protein of gag and Vpr is comparable to wild-type HIV-1 in primary macrophages.

KPNA5 KPNA6 KPNA1

4.32e-0864639918876
Pubmed

Phosphorylation of residue 131 of HIV-1 matrix is not required for macrophage infection.

KPNA5 KPNA6 KPNA1

4.32e-0864639008157
Pubmed

BIG3 Inhibits the Estrogen-Dependent Nuclear Translocation of PHB2 via Multiple Karyopherin-Alpha Proteins in Breast Cancer Cells.

KPNA5 KPNA6 KPNA1

1.21e-07846326052702
Pubmed

Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha/beta pathway.

KPNA5 KPNA6 KPNA1

1.21e-07846318187047
Pubmed

Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA.

KPNA5 KPNA6 KPNA1

1.21e-0784638552640
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

TUBGCP6 SMARCA4 CHD9 CHD8 KPNA6 INO80 AKAP17A ARGLU1 TUBGCP3 KPNA1 BRWD1

1.68e-071116461131753913
Pubmed

Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein.

KPNA5 KPNA6 KPNA1

1.81e-07946310366569
Pubmed

HIV-1 nuclear import: in search of a leader.

KPNA5 KPNA6 KPNA1

1.81e-07946310525473
Pubmed

The karyophilic properties of human immunodeficiency virus type 1 integrase are not required for nuclear import of proviral DNA.

KPNA5 KPNA6 KPNA1

1.81e-07946310888652
Pubmed

HIV-1 nuclear import: in search of a leader.

KPNA5 KPNA6 KPNA1

1.81e-0794639366553
Pubmed

HIV-1 infection requires a functional integrase NLS.

KPNA5 KPNA6 KPNA1

1.81e-07946311389849
Pubmed

Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.

KPNA5 KPNA6 KPNA1

1.81e-0794631631159
Pubmed

Two nuclear localization signals in the HIV-1 matrix protein regulate nuclear import of the HIV-1 pre-integration complex.

KPNA5 KPNA6 KPNA1

1.81e-07946310860744
Pubmed

Viral protein R regulates nuclear import of the HIV-1 pre-integration complex.

KPNA5 KPNA6 KPNA1

1.81e-0794639463369
Pubmed

Reassessment of the roles of integrase and the central DNA flap in human immunodeficiency virus type 1 nuclear import.

KPNA5 KPNA6 KPNA1

1.81e-07946312414950
Pubmed

A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells.

KPNA5 KPNA6 KPNA1

1.81e-0794638105392
Pubmed

Cellular distribution and karyophilic properties of matrix, integrase, and Vpr proteins from the human and simian immunodeficiency viruses.

KPNA5 KPNA6 KPNA1

1.81e-07946311035935
Pubmed

HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway.

KPNA5 KPNA6 KPNA1

1.81e-0794639275210
Pubmed

Characterization of the nuclear import pathway for HIV-1 integrase.

KPNA5 KPNA6 KPNA1

1.81e-07946311278458
Pubmed

Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear import.

KPNA5 KPNA6 KPNA1

1.81e-07946312368302
Pubmed

HIV-1 p17 and IFN-gamma both induce fructose 1,6-bisphosphatase.

KPNA5 KPNA6 KPNA1

2.58e-07104639282826
Pubmed

HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr.

KPNA5 KPNA6 KPNA1

3.55e-07114639562972
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TUBGCP6 KIF21B CHD8 KDM4A INO80 DDX55 MAP4K4 BMS1

4.27e-0752946814621295
Pubmed

Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr.

KPNA5 KPNA6 KPNA1

4.72e-07124637494303
Pubmed

Acetylation-dependent regulation of Skp2 function.

KPNA5 KPNA6 KPNA1

4.72e-071246322770219
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

CEP350 KPNA5 KPNA6 EIF3D AKAP17A CCDC86 TUBGCP3 KPNA1 BMS1

5.42e-0775446933060197
Pubmed

Heat-shock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral preintegration complex.

KPNA5 KPNA6 KPNA1

9.74e-071546310964507
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

ZNF462 SMARCA4 RPL24 NEPRO INO80 DDX55 CCDC86 TUBGCP3 BMS1

1.42e-0684746935850772
Pubmed

Expression of the Wdr9 gene and protein products during mouse development.

SMARCA4 BRWD1

1.71e-06246212889071
Pubmed

Involvement of classical bipartite/karyopherin nuclear import pathway components in acrosomal trafficking and assembly during bovine and murid spermiogenesis.

KPNA6 KPNA1

1.71e-06246222156475
Pubmed

R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.

TUBGCP6 RPL24 KPNA6 INO80 TUBGCP3 KPNA1

2.75e-0630046628561026
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

NEPRO CHD8 EIF3D INO80 DDX55 AKAP17A CCDC86 ARGLU1 MINK1 KPNA1 BMS1

3.01e-061497461131527615
Pubmed

Exploring the link between MORF4L1 and risk of breast cancer.

KPNA5 PALB2 KPNA1

4.30e-062446321466675
Pubmed

Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domain.

KPNA6 KPNA1

5.13e-06346218716025
Pubmed

Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein.

KPNA5 KPNA1

5.13e-06346212740372
Pubmed

Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus.

KPNA6 KPNA1

5.13e-06346221245837
Pubmed

Probing the specificity of binding to the major nuclear localization sequence-binding site of importin-alpha using oriented peptide library screening.

KPNA5 KPNA1

5.13e-06346220406804
Pubmed

[Identification of prototype foamy virus Bel1 nuclear localization signal and its corresponding importins].

KPNA6 KPNA1

5.13e-06346225272585
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

TUBGCP6 SMARCA4 SYNRG MAP4K4 CCDC86 ARGLU1 PALB2 MINK1

7.17e-0677446815302935
Pubmed

Molecular determinants for nuclear import of influenza A PB2 by importin α isoforms 3 and 7.

KPNA6 KPNA1

1.03e-05446225599645
Pubmed

Importin α3 regulates chronic pain pathways in peripheral sensory neurons.

KPNA6 KPNA1

1.03e-05446232792398
Pubmed

Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family.

KPNA5 KPNA6

1.03e-0544629395085
Pubmed

Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements.

KPNA6 KPNA1

1.03e-05446216298512
Pubmed

A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway.

KPNA5 KPNA1

1.03e-05446212610148
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

CHD9 CHD8 KPNA6 INO80 CCDC86 KPNA1

1.30e-0539446627248496
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

SMARCA4 RPL24 KPNA6 EIF3D DDX55 KPNA1 BMS1

1.38e-0560546728977666
Pubmed

Human transcription factor protein interaction networks.

ZNF462 SMARCA4 RPL24 NEPRO CHD8 PABPC1L EIF3D INO80 CCDC86 BMS1

1.40e-051429461035140242
Pubmed

GCP5 and GCP6: two new members of the human gamma-tubulin complex.

TUBGCP6 TUBGCP3

1.71e-05546211694571
Pubmed

Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.

KPNA5 KPNA1

1.71e-05546215929992
Pubmed

Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal.

KPNA5 KPNA1

1.71e-05546219961612
Pubmed

Importin α5 Regulates Anxiety through MeCP2 and Sphingosine Kinase 1.

KPNA6 KPNA1

1.71e-05546230540948
Pubmed

Identification of novel homologues of mouse importin alpha, the alpha subunit of the nuclear pore-targeting complex, and their tissue-specific expression.

KPNA6 KPNA1

1.71e-0554629369227
Pubmed

Nuclear localization of Duplin, a beta-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway.

CHD8 KPNA1

1.71e-05546211744694
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

KPNA5 RPL24 CHD9 CHD8 KPNA6 PABPC1L EIF3D SCN1A KPNA1

1.71e-05115346929845934
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

SMARCA4 CHD8 KPNA6 DDX55 WDR4 KPNA1

2.42e-0544046634244565
Pubmed

IPO3-mediated Nonclassical Nuclear Import of NF-κB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-κB Activation.

KPNA6 KPNA1

2.56e-05646226060253
Pubmed

Three distinct classes of the alpha-subunit of the nuclear pore-targeting complex (importin-alpha) are differentially expressed in adult mouse tissues.

KPNA6 KPNA1

2.56e-05646210026238
Pubmed

Retinoblastoma-binding Protein 4-regulated Classical Nuclear Transport Is Involved in Cellular Senescence.

KPNA5 KPNA1

2.56e-05646226491019
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

ZNF462 SMARCA4 KIF21B CHD8 MAP4K4 ARGLU1 MINK1 KPNA1

3.44e-0596346828671696
Pubmed

Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import.

KPNA6 KPNA1

3.58e-05746210523667
Pubmed

Active nuclear import and cytoplasmic retention of activation-induced deaminase.

KPNA5 KPNA1

3.58e-05746219412186
Pubmed

Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development.

SMARCA4 KDM4A

3.58e-05746221445275
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

TUBGCP6 RPL24 CHD8 INO80 THSD7A TUBGCP3

3.71e-0547546631040226
Pubmed

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

CEP350 SMARCA4 RPL24 DDX55 CCDC86 BMS1

4.07e-0548346636912080
Pubmed

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.

CEP350 TUBGCP6 CCSAP TUBGCP3

4.24e-0514646421399614
Pubmed

A High-Density Map for Navigating the Human Polycomb Complexome.

KPNA5 ZNF462 KPNA6 INO80 FAM199X KPNA1

4.66e-0549546627705803
Pubmed

An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A.

KPNA5 KPNA6

4.77e-05846220818336
Pubmed

Blocking nuclear import of pre-integration complex: an emerging anti-HIV-1 drug discovery paradigm.

KPNA5 KPNA1

4.77e-05846220015032
Pubmed

The nucleoporin MEL-28 promotes RanGTP-dependent γ-tubulin recruitment and microtubule nucleation in mitotic spindle formation.

TUBGCP6 TUBGCP3

4.77e-05846224509916
Pubmed

Importin α7 is essential for zygotic genome activation and early mouse development.

KPNA6 KPNA1

4.77e-05846221479251
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

SMARCA4 RPL24 CHD8 KPNA6 EIF3D AKAP17A ARGLU1 KPNA1 BMS1

4.87e-05131846930463901
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

SMARCA4 CHD8 KDM4A INO80

5.63e-0515746430186101
Pubmed

The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

KPNA5 SMARCA4 KPNA6

6.03e-055746321555454
Pubmed

Changing expression and subcellular distribution of karyopherins during murine oogenesis.

KPNA6 KPNA1

6.12e-05946226399853
Pubmed

Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules.

TUBGCP6 TUBGCP3

6.12e-05946211956313
Pubmed

Transportin 3 and importin α are required for effective nuclear import of HIV-1 integrase in virus-infected cells.

KPNA5 KPNA1

6.12e-05946221326825
Pubmed

Dynamic changes of NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis.

TUBGCP6 TUBGCP3

6.12e-0594628838651
Pubmed

14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1).

KPNA5 KPNA1

6.12e-05946215057270
Pubmed

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction.

KPNA6 KPNA1

7.65e-051046219270695
InteractionNUP43 interactions

ZNF462 SMARCA4 CHD9 NEPRO CHD8 ARGFX INO80 FAM199X DDX55 ARGLU1 BMS1

1.16e-076254611int:NUP43
InteractionMECP2 interactions

ZNF462 SMARCA4 RPL24 CHD9 NEPRO EIF3D INO80 DDX55 AKAP17A MAP4K4 CCDC86 ARGLU1 TUBGCP3 BMS1

6.07e-0712874614int:MECP2
InteractionANKRD36B interactions

CHD9 CHD8 CCDC66 AKAP17A

1.05e-0560464int:ANKRD36B
InteractionANOS1 interactions

NEPRO DDX55 AKAP17A CCDC86 BMS1

1.82e-05143465int:ANOS1
InteractionLARP7 interactions

KPNA5 RPL24 CHD9 CHD8 KPNA6 PABPC1L EIF3D CCDC86 SCN1A KPNA1 BMS1

3.10e-0511134611int:LARP7
InteractionFOXE1 interactions

KPNA5 SMARCA4 KPNA6 KPNA1

3.48e-0581464int:FOXE1
InteractionNOP56 interactions

KPNA5 SMARCA4 RPL24 KPNA6 DDX55 CCDC86 KPNA1 BMS1

3.94e-05570468int:NOP56
InteractionDOT1L interactions

ZNF462 SMARCA4 RPL24 NEPRO INO80 DDX55 CCDC86 TUBGCP3 BMS1

7.36e-05807469int:DOT1L
InteractionMEN1 interactions

ZNF462 SMARCA4 RPL24 NEPRO CHD8 KPNA6 INO80 DDX55 CCDC86 BMS1

8.75e-0510294610int:MEN1
InteractionZRANB2 interactions

KPNA5 AKAP17A MAP4K4 CCDC86 MINK1

8.81e-05199465int:ZRANB2
InteractionCBX3 interactions

ZNF462 SMARCA4 RPL24 CHD9 CHD8 KPNA6 HTR2C MAP4K4

9.49e-05646468int:CBX3
InteractionPOLR1G interactions

SMARCA4 CHD9 NEPRO CHD8 DDX55 KPNA1 BMS1

1.12e-04489467int:POLR1G
InteractionPOLR3C interactions

KPNA5 SMARCA4 KPNA6 KPNA1

1.15e-04110464int:POLR3C
InteractionBRD3 interactions

SMARCA4 CHD9 CHD8 INO80 AKAP17A CCDC86 ARGLU1

1.19e-04494467int:BRD3
InteractionKPNA1 interactions

KPNA5 SMARCA4 CHD8 KPNA6 DDX55 KPNA1

1.39e-04351466int:KPNA1
InteractionCD2BP2 interactions

TUBGCP6 KPNA6 CHRM3 TUBGCP3 KPNA1

1.81e-04232465int:CD2BP2
InteractionALKBH5 interactions

KPNA6 MINK1 KPNA1

2.02e-0450463int:ALKBH5
InteractionCENPA interactions

ZNF462 KPNA6 DDX55 ARGLU1 BRWD1 BMS1

2.05e-04377466int:CENPA
InteractionCHD4 interactions

KPNA5 ZNF462 SMARCA4 RPL24 KPNA6 EIF3D DDX55 KPNA1 BMS1

2.30e-04938469int:CHD4
InteractionH3-3A interactions

SMARCA4 CHD9 CHD8 KDM4A INO80 DDX55 KPNA1 BRWD1

2.62e-04749468int:H3-3A
InteractionSLX4 interactions

CEP350 KPNA5 ZNF462 SMARCA4 CHD9 CHD8 KPNA1

2.93e-04572467int:SLX4
InteractionH2BC3 interactions

CHD9 CHD8 WDR4 CCDC86 PALB2 KPNA1

3.05e-04406466int:H2BC3
InteractionPOU5F1 interactions

ZNF462 SMARCA4 RPL24 EIF3D INO80 TUBGCP3 BRWD1

3.32e-04584467int:POU5F1
InteractionRPL23A interactions

RPL24 NEPRO EIF3D DDX55 CCDC86 TUBGCP3 BMS1

4.15e-04606467int:RPL23A
InteractionNALCN interactions

CHRM3 SCN1A

4.56e-0414462int:NALCN
InteractionSREK1IP1 interactions

KPNA5 KPNA6 KPNA1

4.60e-0466463int:SREK1IP1
GeneFamilyArmadillo repeat containing|Importins

KPNA5 KPNA6 KPNA1

2.39e-0618273596
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

KPNA5 KPNA6 KPNA1

3.52e-0543273409
GeneFamilyWD repeat domain containing

KIF21B WDR4 BRWD1

6.80e-03262273362
GeneFamilyPRD class homeoboxes and pseudogenes

ARGFX DMBX1

8.28e-0392272521
CoexpressionAtlasDevelopingKidney_e11.5_metaneph mesench_emap-3843_k-means-cluster#3_top-relative-expression-ranked_1000

TUBGCP6 KIF21B NEPRO CSRNP2 MAP4K4 PALB2 TBCC

1.52e-05376467gudmap_developingKidney_e11.5_metaneph mesench_1000_k3
ToppCell5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIF21B CHD8 THSD7A CCDC86 CHRM3 MINK1

4.01e-08188466524d1d928c9386acf20e53d31894107dd7290dc7
ToppCell5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIF21B CHD8 THSD7A CCDC86 CHRM3 MINK1

4.01e-08188466f5a2f324f3f6c5078d57130392d3f1ba74f29094
ToppCell5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIF21B CHD8 THSD7A CCDC86 CHRM3 MINK1

4.01e-081884661b57995d70cf81212e8d46dfaf44dbaf9c7bc4d5
ToppCell5'-Airway_Nasal-Endothelial-Blood_vessel_EC|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIF21B CHD8 THSD7A CCDC86 CHRM3 MINK1

4.01e-08188466cd2d1f8e43c252dd8730a5758458ef63e7ffc836
ToppCell5'-Airway_Nasal-Endothelial|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIF21B CHD8 THSD7A CCDC86 CHRM3 MINK1

4.01e-081884666c9d5e4014f807149328ff4eabd5e86dfe18094d
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

KPNA5 PABPC1L ANKRD36 THSD7A ARGLU1 BRWD1

4.68e-081934669337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellC_00|World / shred on cell type and cluster

CHD9 ANKRD36 CSRNP2 ARGLU1

3.47e-05179464da2dadc3266ffebd4a34ac61bfa05fddcadcde4c
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

FHDC1 INO80 CHRM3 SCN1A

4.20e-05188464ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCell(0)_NK_cells-(0)_NK_CD160pos|(0)_NK_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)

CHD9 SYNRG ARGLU1 SLFN13

4.84e-051954646cbeceb52bb207f3c074e57b5b3f7cfb24fd5877
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-35|World / Primary Cells by Cluster

ZNF462 CHD9 ANKRD36 MAP4K4

5.14e-05198464de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.

RPL24 CHD9 ANKRD36 THSD7A

5.34e-05200464ac0e023dbb383bbc46c5cc525431778be8f7ef46
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Interneuron|10w / Sample Type, Dataset, Time_group, and Cell type.

KIF21B ANKRD36 DMBX1 GLRA2

5.34e-05200464f5c63ef52bd7a898cf009b8bf9b2f7f4890d1c9b
DiseaseCHARGE syndrome (implicated_via_orthology)

CHD9 CHD8

4.54e-057442DOID:0050834 (implicated_via_orthology)
Diseaseautism spectrum disorder (implicated_via_orthology)

CHD9 CHD8 HTR2C SCN1A

7.83e-05152444DOID:0060041 (implicated_via_orthology)
DiseaseAutism Spectrum Disorders

CHD8 SCN1A GLRA2

2.81e-0485443C1510586
DiseaseColorectal cancer, hereditary nonpolyposis, type 1

SMARCA4 PALB2

3.66e-0419442C2936783
DiseaseHereditary Non-Polyposis Colon Cancer Type 2

SMARCA4 PALB2

3.66e-0419442C1333991
Diseaseanxiety disorder (implicated_via_orthology)

HTR2C SCN1A

4.93e-0422442DOID:2030 (implicated_via_orthology)
DiseasePrimary microcephaly

TUBGCP6 TUBGCP3

4.93e-0422442C0431350
DiseaseHereditary Nonpolyposis Colorectal Neoplasms

SMARCA4 PALB2

6.90e-0426442C0009405
DiseaseHereditary non-polyposis colorectal cancer syndrome

SMARCA4 PALB2

7.45e-0427442C1112155
DiseaseHereditary Nonpolyposis Colorectal Cancer

SMARCA4 PALB2

8.60e-0429442C1333990
Diseasekynurenine measurement

THSD7A BRWD1

1.55e-0339442EFO_0008529
Diseaseepilepsy

CHRM3 SCN1A

1.72e-0341442EFO_0000474
Diseaseepilepsy (implicated_via_orthology)

MAP4K4 SCN1A MINK1

1.86e-03163443DOID:1826 (implicated_via_orthology)
Diseasevascular endothelial growth factor measurement

ZNF462 CHRM3

3.18e-0356442EFO_0004762
Diseaseankle injury

CHD9 ARGLU1

3.52e-0359442EFO_1002021
DiseaseIntellectual Disability

ZNF462 CHD8 WDR4 SCN1A

4.37e-03447444C3714756

Protein segments in the cluster

PeptideGeneStartEntry
IQKRRSNRQVKRKKY

CHD8

571

Q9HCK8
KERRRQEKKQRRAEN

CCDC86

291

Q9H6F5
KRQKQLRRKNVRFDQ

CSRNP2

56

Q9H175
KKAEFERQRKIRQQE

ARGLU1

106

Q9NWB6
KKRRKQQYQQRQSVI

CHRM3

566

P20309
NQDQNARRRKKKERR

HTR2C

281

P28335
FRNRRFKLKKQQQQQ

ARGFX

126

A6NJG6
KNRRQVEKRKLVAQR

CCSAP

221

Q6IQ19
RFAIQQEKKKRRNVE

ANKRD36

1436

A6QL64
KKLFRIQGQKERRNQ

BMS1

1256

Q14692
QSRRRNTQRKDKKQQ

DEFB132

76

Q7Z7B7
IQLRKQKREEQLFKR

KPNA5

36

O15131
RQQEETNRVKERKRK

INO80

1286

Q9ULG1
LRQLQRLKEQEQKQR

FHDC1

471

Q9C0D6
QKRIEQQKEQRRRLE

MAP4K4

396

O95819
IQLRKQKREQQLFKR

KPNA6

36

O60684
QKREQQLFKRRNVEL

KPNA6

41

O60684
REKQRQKLLEQQRRE

DDX55

491

Q8NHQ9
KQRKLQQKAFRKRQL

FAM199X

336

Q6PEV8
QQKAFRKRQLKEQRQ

FAM199X

341

Q6PEV8
QLKKEQRRQEFQIRA

KIF21B

786

O75037
KQEKKRQRVINSRYR

KDM4A

1036

O75164
QRRLQFEEKKKQREI

TUBGCP3

801

Q96CW5
RKREQFQRLKEQFVK

TUBGCP6

701

Q96RT7
AQKRVERQNELKRRF

PABPC1L

266

Q4VXU2
FKQNQQKKIVRRKRP

LRRIQ1

756

Q96JM4
RRKKQQKRTFISQER

PALB2

146

Q86YC2
RIQQKIKRFKLRQAQ

CHD9

741

Q3L8U1
NRRAKFRKKQRSLQK

DMBX1

121

Q8NFW5
RERIRLQKKFQKQFG

EIF3D

131

O15371
KQLQKQREEKKVRRQ

CCDC66

721

A2RUB6
VRQQEERKRKQNEEK

CEP350

601

Q5VT06
QKFNEKLRRSQRFKQ

BRWD1

1426

Q9NSI6
KEFLRLRRRQKRQNK

GLRA2

346

P23416
RKKLQKTQRDQERAR

SLFN13

31

Q68D06
REQRKLQEKEQQRRL

MINK1

416

Q8N4C8
ARELIKKKRNRNRQN

THSD7A

296

Q9UPZ6
KKKRNRNRQNRQENK

THSD7A

301

Q9UPZ6
EERKRRQFEEQKQKL

SYNRG

136

Q9UMZ2
RKQKREEQLFKRRNV

KPNA1

36

P52294
SQNKFLRRQRKPQRK

NEPRO

446

Q6NW34
LEKQQKIEQERKRRQ

SMARCA4

456

P51532
ERRNRRKKRKQKEQS

SCN1A

496

P35498
EQKQRDRELRRNQKK

AKAP17A

326

Q02040
RLQKLEQQRRLFEKK

TULP2

21

O00295
EQQRRLFEKKQRQKR

TULP2

26

O00295
EIQKKRTRRAVKFQR

RPL24

66

P83731
RQLEVERRKQKRQNQ

TBCC

36

Q15814
ERRKQKRQNQEVEKE

TBCC

41

Q15814
EEFQKRAKRQERRKQ

ZNF462

1916

Q96JM2
EERLQQQLEKKQRRR

WDR4

376

P57081