Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ARM-type_fold	DOCK5 CLTCL1 ATR UPF2 CLTC CTNNBL1 XPO1 TNPO3 ITPR2	4.72e-06	339	70	9	IPR016024
Domain	Clathrin_H-chain_propeller_rpt	CLTCL1 CLTC	1.38e-05	2	70	2	IPR022365
Domain	Clathrin-link	CLTCL1 CLTC	1.38e-05	2	70	2	PF09268
Domain	-	CLTCL1 CLTC	1.38e-05	2	70	2	2.130.10.110
Domain	Clathrin_H-chain_link/propller	CLTCL1 CLTC	1.38e-05	2	70	2	IPR016025
Domain	Clathrin_propel	CLTCL1 CLTC	1.38e-05	2	70	2	PF01394
Domain	Clathrin_heavy_chain	CLTCL1 CLTC	1.38e-05	2	70	2	IPR016341
Domain	Clathrin_H-chain_linker_core	CLTCL1 CLTC	1.38e-05	2	70	2	IPR015348
Domain	Clathrin_H-chain_propeller_N	CLTCL1 CLTC	1.38e-05	2	70	2	IPR001473
Domain	Clathrin_H-chain_linker	CLTCL1 CLTC	4.14e-05	3	70	2	IPR012331
Domain	CLH	CLTCL1 CLTC	4.14e-05	3	70	2	SM00299
Domain	Xpo1	XPO1 TNPO3	2.06e-04	6	70	2	PF08389
Domain	Exportin-1/Importin-b-like	XPO1 TNPO3	2.06e-04	6	70	2	IPR013598
Domain	Clathrin	CLTCL1 CLTC	2.87e-04	7	70	2	PF00637
Domain	CHCR	CLTCL1 CLTC	2.87e-04	7	70	2	PS50236
Domain	Clathrin_H-chain/VPS_repeat	CLTCL1 CLTC	3.82e-04	8	70	2	IPR000547
Domain	TNF_CS	TNFSF8 CD70	7.45e-04	11	70	2	IPR021184
Domain	tRNA_anti-codon	DARS1 RPA4	8.92e-04	12	70	2	PF01336
Domain	NA-bd_OB_tRNA	DARS1 RPA4	8.92e-04	12	70	2	IPR004365
Domain	Myotubularin-like_Pase_dom	MTMR7 MTMR3	1.22e-03	14	70	2	IPR010569
Domain	PPASE_MYOTUBULARIN	MTMR7 MTMR3	1.22e-03	14	70	2	PS51339
Domain	Myotubularin_fam	MTMR7 MTMR3	1.22e-03	14	70	2	IPR030564
Domain	Myotub-related	MTMR7 MTMR3	1.22e-03	14	70	2	PF06602
Domain	TNF_1	TNFSF8 CD70	1.82e-03	17	70	2	PS00251
Domain	TNF	TNFSF8 CD70	2.04e-03	18	70	2	SM00207
Domain	TNF	TNFSF8 CD70	2.27e-03	19	70	2	PF00229
Domain	TNF_dom	TNFSF8 CD70	2.27e-03	19	70	2	IPR006052
Domain	TNF_2	TNFSF8 CD70	2.27e-03	19	70	2	PS50049
Domain	ARM-like	SETX ATR CTNNBL1 XPO1 TNPO3	3.43e-03	270	70	5	IPR011989
Domain	TYR_PHOSPHATASE_2	MTMR7 STYX MTMR3	4.27e-03	87	70	3	PS50056
Domain	TYR_PHOSPHATASE_dom	MTMR7 STYX MTMR3	4.27e-03	87	70	3	IPR000387
Domain	-	MTMR7 STYX MTMR3	4.99e-03	92	70	3	3.90.190.10
Domain	Prot-tyrosine_phosphatase-like	MTMR7 STYX MTMR3	6.12e-03	99	70	3	IPR029021
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	STIM1 P2RX5 ITPR2	2.87e-05	16	54	3	M26945
Pubmed	Foxg1 coordinates the switch from nonradially to radially migrating glutamatergic subtypes in the neocortex through spatiotemporal repression.	TYRP1 EYA2 ZFPM2	3.64e-06	15	71	3	23523356
Pubmed	Defining the membrane proteome of NK cells.	CLTCL1 GBP5 GIT1 CENPE STAU2 CLTC CTNNBL1 DAD1 DARS1 XPO1 COG8 ITPR2	4.00e-06	1168	71	12	19946888
Pubmed	Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.	CLTCL1 CLTC	4.11e-06	2	71	2	8733129
Pubmed	CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function.	CLTCL1 CLTC	4.11e-06	2	71	2	29097553
Pubmed	The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.	CLTCL1 CLTC	4.11e-06	2	71	2	20065094
Pubmed	Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.	CLTCL1 CLTC	1.23e-05	3	71	2	19509056
Pubmed	Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestry.	SLIT3 CTNNBL1	1.23e-05	3	71	2	19228371
Pubmed	Construction of a BALB/c congenic mouse, C.C3H-Lpsd, that expresses the Lpsd allele: analysis of chromosome 4 markers surrounding the Lps gene.	TYRP1 TNFSF8	1.23e-05	3	71	2	7927709
Pubmed	Interaction between TRPC1/TRPC4 assembly and STIM1 contributes to store-operated Ca2+ entry in mesangial cells.	STIM1 TRPC4	1.23e-05	3	71	2	19307462
Pubmed	Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.	CLTCL1 CLTC	1.23e-05	3	71	2	22891263
Pubmed	The Ca(2+) sensor stromal interaction molecule 1 (STIM1) is necessary and sufficient for the store-operated Ca(2+) entry function of transient receptor potential canonical (TRPC) 1 and 4 channels in endothelial cells.	STIM1 TRPC4	1.23e-05	3	71	2	22210847
Pubmed	TRPC1 and TRPC4 channels functionally interact with STIM1L to promote myogenesis and maintain fast repetitive Ca2+ release in human myotubes.	STIM1 TRPC4	1.23e-05	3	71	2	28185894
Pubmed	Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration.	CLTCL1 CLTC	1.23e-05	3	71	2	15133132
Pubmed	CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF.	TYRP1 TNFSF8	1.23e-05	3	71	2	8391931
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	STIM1 UPF2 GIT1 KDM5A STAU2 KPRP TNRC6B DARS1 DYSF	1.65e-05	724	71	9	36232890
Pubmed	Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.	TRPC4 ITPR2	2.46e-05	4	71	2	11163362
Pubmed	HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.	CLTCL1 CLTC	2.46e-05	4	71	2	11517213
Pubmed	Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression.	STAU2 TNRC6B MCCC2 HNRNPUL1	3.57e-05	90	71	4	33087562
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	GSDME ATR DARS1 XPO1 TNPO3	3.75e-05	183	71	5	23956138
Pubmed	The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity.	MTMR3 MLST8	4.09e-05	5	71	2	26787466
Pubmed	Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.	CLTCL1 CLTC	4.09e-05	5	71	2	10436022
Pubmed	Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1.	ATR UPF2	4.09e-05	5	71	2	16086026
Pubmed	Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage.	ATR RPA4	4.09e-05	5	71	2	15929725
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	CLTCL1 CLTC KPRP TNRC6B DARS1 XPO1 HNRNPUL1 TNPO3	5.21e-05	647	71	8	26618866
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TTYH1 ATRX GIT1 KDM5A PPFIBP1 CLTC MTMR3 DAD1 DARS1 HNRNPUL1 MLST8	5.62e-05	1285	71	11	35914814
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	STIM1 CLTC DAD1 TNRC6B DARS1 XPO1 TNPO3 COG8	5.80e-05	657	71	8	36180527
Pubmed	A high-resolution map in the chromosomal region surrounding the Lps locus.	TYRP1 TNFSF8	6.13e-05	6	71	2	8838309
Pubmed	Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.	ATR ATRX	6.13e-05	6	71	2	17118963
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	STIM1 HIVEP1 SETX GIT1 KDM5A PPFIBP1 HNRNPUL1 RASSF7 TNPO3	6.32e-05	861	71	9	36931259
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	ONECUT2 SETX UPF2 KDM5A STAU2 CLTC CTNNBL1 TNRC6B XPO1 HNRNPUL1	6.73e-05	1082	71	10	38697112
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	GSDME HIVEP1 UPF2 GIT1 KDM5A CLTC DYSF	7.05e-05	497	71	7	23414517
Pubmed	Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication.	ATR UPF2	8.57e-05	7	71	2	21829167
Pubmed	A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism.	CLTCL1 CLTC	8.57e-05	7	71	2	19478182
Pubmed	Enhanced expression of Stim, Orai, and TRPC transcripts and proteins in endothelial progenitor cells isolated from patients with primary myelofibrosis.	STIM1 TRPC4	8.57e-05	7	71	2	24603752
Pubmed	Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.	CLTC XPO1	8.57e-05	7	71	2	16314522
Pubmed	Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.	MTMR7 CLTCL1 STYX ATR MTMR3 XPO1 EYA2 TNPO3 ZFPM2	1.14e-04	931	71	9	27432908
Pubmed	The human RNA surveillance factor UPF1 is required for S phase progression and genome stability.	ATR UPF2	1.47e-04	9	71	2	16488880
Pubmed	Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival.	GIT1 MLST8	1.47e-04	9	71	2	27340174
Pubmed	Genetic mapping of the whirler mutation.	TYRP1 TNFSF8	1.47e-04	9	71	2	10337627
Pubmed	A co-evolution perspective of the TNFSF and TNFRSF families in the immune system.	TNFSF8 CD70	1.47e-04	9	71	2	12860530
Pubmed	Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.	STIM1 ITPR2	1.47e-04	9	71	2	25737585
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	HIVEP1 ATR ATRX GIT1 KDM5A CLTC XPO1 HNRNPUL1	1.79e-04	774	71	8	15302935
Pubmed	Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.	MTMR7 MTMR3	1.83e-04	10	71	2	9736772
Pubmed	CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.	CLTCL1 CLTC	1.83e-04	10	71	2	25898166
Pubmed	Characterization of ubiquitination dependent dynamics in growth factor receptor signaling by quantitative proteomics.	CLTC HNRNPUL1	1.83e-04	10	71	2	21956701
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	STIM1 DOCK5 SETX PPFIBP1 CLTC TNRC6B MCCC2 HNRNPUL1	1.84e-04	777	71	8	35844135
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	HIVEP1 SETX ATRX GIT1 CENPE CLTC MCCC2	1.99e-04	588	71	7	38580884
Pubmed	A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.	CTNNBL1 RASSF7 TNPO3	2.20e-04	57	71	3	16730941
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	EYS NADSYN1 SETX STYX MTMR3 EYA2	2.21e-04	420	71	6	28065597
Pubmed	Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.	ATR MLST8	2.23e-04	11	71	2	20427287
Pubmed	Y chromosome damage underlies testicular abnormalities in ATR-X syndrome.	ATRX ZFPM2	2.23e-04	11	71	2	38616920
Pubmed	Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion.	CLTCL1 CLTC	2.23e-04	11	71	2	29604273
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	SETX KDM5A CLTC KPRP XPO1	2.41e-04	272	71	5	31010829
Pubmed	Organization and evolutionary relatedness of OR37 olfactory receptor genes in mouse and human.	OR13C5 OR13C2	2.68e-04	12	71	2	12906860
Pubmed	Rheb binds and regulates the mTOR kinase.	ATR MLST8	2.68e-04	12	71	2	15854902
Pubmed	Congenital diaphragmatic hernia: comparison of animal models and relevance to the human situation.	SLIT3 ZFPM2	2.68e-04	12	71	2	19325248
Pubmed	Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions.	MTMR7 MTMR3	2.68e-04	12	71	2	16787938
Pubmed	Common single-nucleotide polymorphisms in DNA double-strand break repair genes and breast cancer risk.	ATR ATRX	3.16e-04	13	71	2	19064565
Pubmed	Iris phenotypes and pigment dispersion caused by genes influencing pigmentation.	TYRP1 RABGGTA	4.24e-04	15	71	2	18715234
Pubmed	Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.	CLTC KPRP DARS1 MCCC2 HNRNPUL1 ECM1	4.90e-04	488	71	6	31324722
Pubmed	The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.	CLTC KPRP DARS1 XPO1 TNPO3	5.06e-04	320	71	5	28685749
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	STIM1 PPFIBP1 FASTKD1 MCCC2 XPO1 TAF4B ECM1	5.15e-04	689	71	7	36543142
Pubmed	The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.	XPO1 HNRNPUL1	5.48e-04	17	71	2	10668806
Pubmed	Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation.	STIM1 TRPC4	5.48e-04	17	71	2	22411552
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	STIM1 GIT1 PPFIBP1 CLTC CTNNBL1 TNRC6B DARS1 MCCC2 XPO1 HNRNPUL1	5.81e-04	1415	71	10	28515276
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	ATRX CLTC CTNNBL1 DARS1 XPO1	5.98e-04	332	71	5	32786267
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	HIVEP1 ATR ATRX CLTC CTNNBL1 KPRP DARS1 MCCC2 XPO1 HNRNPUL1	6.13e-04	1425	71	10	30948266
Pubmed	CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1.	KPRP HNRNPUL1	6.16e-04	18	71	2	33361760
Pubmed	Comparative genomic analysis of eutherian tumor necrosis factor ligand genes.	TNFSF8 CD70	6.16e-04	18	71	2	26646413
Pubmed	Cd14, Gbp1, and Pla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses.	MTMR7 ELOA2	6.87e-04	19	71	2	16705022
Pubmed	Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.	ATR MLST8	6.87e-04	19	71	2	20801936
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	STIM1 ELOA2 GBP5 FASTKD1 CLTC DAD1 DARS1 MCCC2 XPO1 ECM1	7.05e-04	1451	71	10	30550785
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	DOCK5 SETX CENPE CLTC CTNNBL1 EVPL ITPR2	7.60e-04	736	71	7	29676528
Pubmed	Identification of Protor as a novel Rictor-binding component of mTOR complex-2.	CLTC MLST8	7.62e-04	20	71	2	17461779
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	DOCK5 ATR CLTC XPO1	7.92e-04	202	71	4	33005030
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	MTMR7 STYX MTMR3 EVPL XPO1 EYA2 ECM1 TNPO3	8.23e-04	974	71	8	28675297
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	STIM1 PPFIBP1 FASTKD1 MTMR3 DAD1 TNRC6B TNPO3	8.75e-04	754	71	7	33060197
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	CENPE STAU2 TNRC6B TAF4B DYSF	8.92e-04	363	71	5	14691545
Pubmed	Chromosomal mapping of five mouse G protein gamma subunits.	TYRP1 TNFSF8	9.24e-04	22	71	2	10191100
Pubmed	SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.	SETX CLTC KPRP DARS1 HNRNPUL1 ECM1	9.84e-04	558	71	6	27591049
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	HIVEP1 ATRX HNRNPUL1 SNURF ECM1 ZFPM2	1.00e-03	560	71	6	21653829
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	STAU2 CLTC MCCC2 XPO1 TNPO3 COG8	1.00e-03	560	71	6	35241646
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	UPF2 PPFIBP1 STAU2 CLTC EVPL DARS1 XPO1 HNRNPUL1 ITPR2	1.02e-03	1257	71	9	36526897
Pubmed	Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span.	ATR ATRX	1.20e-03	25	71	2	23563309
Pubmed	Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway.	GSDME GBP5	1.20e-03	25	71	2	35139355
Pubmed	BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.	HIVEP1 CLTCL1 CLTC TNRC6B	1.20e-03	226	71	4	25900982
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DOCK5 GSDME SETX ATR ATRX SFI1	1.22e-03	582	71	6	20467437
Pubmed	KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer.	CLTC DARS1 XPO1	1.28e-03	104	71	3	36055981
Pubmed	Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.	CLTCL1 CLTC	1.29e-03	26	71	2	24067654
Pubmed	Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells.	XPO1 TNPO3	1.29e-03	26	71	2	23181366
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	STIM1 MTMR7 STYX CLTC MTMR3 XPO1 EYA2 ITPR2	1.32e-03	1049	71	8	27880917
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	ATR CLTC	1.40e-03	27	71	2	23027611
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	UPF2 KDM5A STAU2 CLTC CTNNBL1 DARS1 MCCC2 HNRNPUL1 TNPO3	1.41e-03	1318	71	9	30463901
Pubmed	Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development.	CLTC DYSF	1.50e-03	28	71	2	26884322
Pubmed	TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.	CLTC XPO1	1.50e-03	28	71	2	29653964
Pubmed	Vpr and its interactions with cellular proteins.	ATR XPO1	1.50e-03	28	71	2	20012529
Pubmed	Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.	STAU2 CLTC	1.61e-03	29	71	2	21266579
Pubmed	Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).	TGFBR3 CLTC KPRP EVPL ECM1	1.65e-03	417	71	5	19199708
Pubmed	CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.	PPFIBP1 STAU2 CLTC CD70 XPO1	1.66e-03	418	71	5	35338135
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	SETX UPF2 CLTC CTNNBL1 DARS1 MCCC2 XPO1 HNRNPUL1 ECM1	1.69e-03	1353	71	9	29467282
Interaction	COMTD1 interactions	GSDME SETX UPF2 PPFIBP1 VPS8 DARS1 XPO1 TNPO3 COG8	3.01e-08	200	70	9	int:COMTD1
Interaction	GPR17 interactions	SETX ATR PPFIBP1 CYSLTR1 FASTKD1 VPS8 XPO1 TNPO3 COG8 ITPR2	4.80e-08	283	70	10	int:GPR17
Interaction	GCGR interactions	SETX PPFIBP1 FASTKD1 VPS8 TNPO3 COG8	2.28e-06	110	70	6	int:GCGR
Interaction	GYPA interactions	GSDME SETX ATR FASTKD1 VPS8 TNPO3 COG8	2.40e-06	174	70	7	int:GYPA
Interaction	VSIG2 interactions	ATR XPO1 TNPO3 COG8	4.46e-06	32	70	4	int:VSIG2
Interaction	NPTN interactions	SETX CLTCL1 ATR FASTKD1 XPO1 MLST8 TNPO3 COG8	5.34e-06	278	70	8	int:NPTN
Interaction	DSCR9 interactions	TTYH1 GIT1 KDM5A CLTC MTMR3 DARS1	1.21e-05	147	70	6	int:DSCR9
Interaction	KIR2DL4 interactions	SETX FASTKD1 VPS8 CD70 TNPO3	1.89e-05	94	70	5	int:KIR2DL4
Interaction	SCN2B interactions	GSDME ATR FASTKD1 MLST8 TNPO3	1.99e-05	95	70	5	int:SCN2B
Interaction	EFNB1 interactions	TTYH1 GSDME SETX TNFSF8 VPS8 XPO1 TNPO3	2.91e-05	255	70	7	int:EFNB1
Interaction	P2RY10 interactions	CLTCL1 FASTKD1 XPO1 TNPO3 COG8	3.38e-05	106	70	5	int:P2RY10
Interaction	SIGLECL1 interactions	GSDME SETX VPS8 TNPO3 COG8	4.59e-05	113	70	5	int:SIGLECL1
Interaction	B3GNT8 interactions	GSDME ATR TNPO3	5.89e-05	22	70	3	int:B3GNT8
Interaction	FAM234A interactions	B3GALT4 ATR FASTKD1 XPO1 TNPO3	7.71e-05	126	70	5	int:FAM234A
Interaction	GPR45 interactions	GSDME ATR FASTKD1 VPS8 XPO1 TNPO3 COG8	8.12e-05	300	70	7	int:GPR45
Interaction	EEF1E1 interactions	ATR DARS1 XPO1 RPA4 RABGGTA	8.62e-05	129	70	5	int:EEF1E1
Interaction	MLNR interactions	SETX FASTKD1 VPS8 TNPO3	9.19e-05	68	70	4	int:MLNR
Interaction	MTMR3 interactions	MTMR7 HIVEP1 MTMR3 MLST8	1.03e-04	70	70	4	int:MTMR3
Interaction	TRPC1 interactions	STIM1 TRPC4 ITPR2	1.37e-04	29	70	3	int:TRPC1
Interaction	FPR1 interactions	FASTKD1 VPS8 XPO1 MLST8 TNPO3	1.59e-04	147	70	5	int:FPR1
Interaction	POLD1 interactions	ATR ATRX UPF2 CTNNBL1 XPO1 HNRNPUL1 ECM1	1.67e-04	337	70	7	int:POLD1
Cytoband	12p11	KDM5A ITPR2	8.43e-05	9	71	2	12p11
Cytoband	Ensembl 112 genes in cytogenetic band chrXq21	ATRX CYSLTR1 RPA4	1.45e-03	143	71	3	chrXq21
Cytoband	9q31.1	OR13C5 OR13C2	1.86e-03	41	71	2	9q31.1
Cytoband	14q11.2	CARMIL3 DAD1 RABGGTA	2.79e-03	180	71	3	14q11.2
Cytoband	22q12.2	MTMR3 SFI1	3.69e-03	58	71	2	22q12.2
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	MTMR7 MTMR3	5.43e-04	15	42	2	903
GeneFamily	CD molecules\|Endogenous ligands\|Tumor necrosis factor superfamily\|Death inducing signaling complex	TNFSF8 CD70	7.87e-04	18	42	2	781
GeneFamily	Olfactory receptors, family 13	OR13C5 OR13C2	1.29e-03	23	42	2	162
GeneFamily	Phosphoinositide phosphatases	MTMR7 MTMR3	2.50e-03	32	42	2	1079
Drug	Antagonist G	CLTCL1 CLTC CTRL	2.31e-06	9	70	3	CID000163960
Drug	LY294002; Down 200; 10uM; MCF7; HG-U133A	CLTCL1 GIT1 TNFSF8 FASTKD1 CD70 DYSF ITPR2	2.64e-06	199	70	7	258_DN
Drug	Badg	CLTCL1 CLTC	9.32e-06	2	70	2	CID000125951
Drug	Trileucine	CLTCL1 CLTC CTRL	1.51e-05	16	70	3	CID000082546
Drug	Finasteride [98319-26-7]; Up 200; 10.8uM; PC3; HT_HG-U133A	ONECUT2 CLTCL1 GIT1 TRPC4 SFI1 ITPR2	3.04e-05	195	70	6	4300_UP
Drug	(-)-depudecin; Up 200; 1uM; MCF7; HT_HG-U133A_EA	STIM1 TGFBR3 ELOA2 CLTCL1 SFI1 TAF4B	3.04e-05	195	70	6	874_UP
Drug	Pseudopelletierine hydrochloride [6164-62-1]; Up 200; 21uM; HL60; HG-U133A	NADSYN1 P2RX5 GIT1 SFI1 CTRL ECM1	3.22e-05	197	70	6	1774_UP
Drug	Ketoprofen [22071-15-4]; Down 200; 15.8uM; MCF7; HT_HG-U133A	ONECUT2 GIT1 PPFIBP1 TNRC6B SFI1 CTRL	3.31e-05	198	70	6	3626_DN
Drug	Avermectin B1 [71751-41-2]; Down 200; 4.8uM; PC3; HT_HG-U133A	HIVEP1 P2RX5 ATRX MTMR3 EVPL ITPR2	3.31e-05	198	70	6	5864_DN
Drug	Pentolinium bitartrate [52-62-0]; Up 200; 7.4uM; HL60; HT_HG-U133A	DOCK5 KDM5A TRPC4 CTNNBL1 TNRC6B CD70	3.40e-05	199	70	6	2343_UP
Disease	urate measurement, bone density	DOCK5 SLC26A8 EYS GBP5 PPFIBP1 TAF4B THAP9 ITPR2	1.08e-04	619	70	8	EFO_0003923, EFO_0004531
Disease	centronuclear myopathy X-linked (implicated_via_orthology)	MTMR7 MTMR3	1.98e-04	9	70	2	DOID:0111225 (implicated_via_orthology)
Disease	congenital diaphragmatic hernia (implicated_via_orthology)	SLIT3 ZFPM2	3.61e-04	12	70	2	DOID:3827 (implicated_via_orthology)
Disease	response to olanzapine	HIVEP1 ZFPM2	5.71e-04	15	70	2	GO_0097333
Disease	lung cancer (is_implicated_in)	STIM1 ATR TRPC4	7.35e-04	74	70	3	DOID:1324 (is_implicated_in)
Disease	Uterine leiomyoma, estrogen-receptor positive breast cancer	TNRC6B ZFPM2	8.28e-04	18	70	2	EFO_1000649, HP_0000131
Disease	Chronic myeloproliferative disorder	ATR CENPE	9.24e-04	19	70	2	C1292778
Disease	BRCAX breast cancer	CTNNBL1 ITPR2	1.03e-03	20	70	2	EFO_0009443
Disease	body composition measurement	TRPC4 TNRC6B EYA2 DYSF	1.16e-03	193	70	4	EFO_0005106
Disease	Seckel syndrome	ATR CENPE	1.24e-03	22	70	2	C0265202
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	MTMR7 MTMR3	1.48e-03	24	70	2	DOID:10595 (implicated_via_orthology)
Disease	stomach carcinoma (is_marker_for)	KDM5A XPO1	1.48e-03	24	70	2	DOID:5517 (is_marker_for)
Disease	Limb-girdle muscular dystrophy	DYSF TNPO3	1.74e-03	26	70	2	cv:C0686353
Disease	lumbar disc degeneration	EYS HIVEP1	2.02e-03	28	70	2	EFO_0004994
Disease	stimulant use measurement	EYS HIVEP1	2.02e-03	28	70	2	EFO_0600076

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLCNRAVSNPFQQRL	TTYH1	301	Q9H313
NDRPQCVICNNILAN	FAM200B	81	P0CF97
QVALPLVTVNQCRQY	CTRL	176	P40313
AEICNANVPQIRQRV	CTNNBL1	501	Q8WYA6
RQQQDLVAFLQLVGC	GSDME	351	O60443
LVCTAPENLNQRNAI	B3GALT4	76	O96024
APVDFQLLTQQVIQC	GIT1	726	Q9Y2X7
VCIQRFAQAQQQLPL	CD70	36	P32970
QVQGNQLQTAVLCLR	C5orf38	111	Q86SI9
ELRQCNLQQFIQQTG	RASSF7	286	Q02833
FLQNFCRGNPQNQVL	ITPR2	1241	Q14571
IPVDQFRNVCNVNLQ	LRRC9	1111	Q6ZRR7
ACQLQVPTLRQQCAQ	ELOA2	521	Q8IYF1
VPTLRQQCAQVLRNN	ELOA2	526	Q8IYF1
VCLRIQINPQNKADF	DAD1	71	P61803
QGCIRQVIINNQELQ	EYS	2866	Q5T1H1
CCQRNIPLLFLQNIT	MCCC2	391	Q9HCC0
NFQIIQLIIPQERDC	MTMR7	76	Q9Y216
IQVLRINNFEPNCLR	PPFIBP1	776	Q86W92
VQQRFLDVANLNNPC	ZFPM2	756	Q8WW38
QTCPQEQAFRLQQGL	CARMIL3	666	Q8ND23
SRNLQCQRIFQVNAP	MLST8	116	Q9BVC4
CPQNKNRVRNQINAL	EPX	291	P11678
QEFCQDLPRQQRQVR	EVPL	711	Q92817
IPQAIFAQRVLCRSQ	ONECUT2	351	O95948
QLIQQLRTNIQLPAC	COG8	211	Q96MW5
IIQENFPNLARQANV	L1RE1	181	Q9UN81
FPNLARQANVQIQEI	L1RE1	186	Q9UN81
DQRVQNFNLPRLCIQ	GBP5	211	Q96PP8
VRRFQAQLPQVSCVQ	LRRC29	196	Q8WV35
VFVVQLPFCRNNIIN	OR13C5	161	Q8NGS8
VFVVQLPFCRNNIIN	OR13C2	161	Q8NGS9
QQLFSLPCVISQARQ	KDM5A	831	P29375
VIVGNERVQICLQNP	PASD1	576	Q8IV76
FRNRFINPIQNGQCA	ATRX	1776	P46100
FILLQQQNSCNRVPK	ATR	676	Q13535
CKFIQSIPDNQLVRQ	DOCK5	841	Q9H7D0
QPLLERCNNVFLSNV	FASTKD1	246	Q53R41
MCDQQQIQCRLPLQQ	KPRP	1	Q5T749
NLNQICLPNRQHVVY	ECM1	176	Q16610
NIVLNRPFSIQKLNC	FAM217A	476	Q8IXS0
VQSCVIRNLRKNPNF	DYSF	1366	O75923
ICQVNNFFNNRIIAI	CENPE	2296	Q02224
CIQANQIFPRKQLIR	MTMR3	11	Q13615
FLQQLPNCVNRDLID	UPF2	571	Q9HAU5
IQQATQCLNRLIQIA	HNRNPUL1	481	Q9BUJ2
NQQVICSIENNLPFL	PCDHB6	376	Q9Y5E3
NLIVTPNQRQNVCAE	P2RX5	106	Q93086
ALNLINSRPNCVNVL	EYA2	431	O00167
RQLLPNSQSFIQQCV	TAF4B	331	Q92750
QAQRQPIGACVARIQ	SFI1	1221	A8K8P3
VLRQICNAFQNANIL	SLC26A8	741	Q96RN1
QELLLCNNRLQQPAV	RABGGTA	511	Q92696
NFPANLNELVNCIVI	SETX	1866	Q7Z333
QFIELLCQFNPTQVI	VPS8	1031	Q8N3P4
CFLVLRQQQFNVQAL	DARS1	76	P14868
QQIEILCGFQIVNNP	STIM1	431	Q13586
ICIRQNIEANFIKPN	STYX	61	Q8WUJ0
LSANIRQNLQICVQV	CLTC	671	Q00610
LSANIRQNLQLCVQV	CLTCL1	671	P53675
RCIAIVFPVQNINLV	CYSLTR1	121	Q9Y271
INCLRVNTFQDLQNL	SLIT3	391	O75094
QECQLYPRRSQQQQV	SNURF	36	Q9Y675
NNINTIICDLQPQQV	XPO1	616	O14980
LLLFQQARAQFPRQC	TYRP1	16	P17643
IICQLQFLVQCPNNS	TNFSF8	141	P32971
RENQPLNISNNLCFL	USP45	576	Q70EL2
VRIQDVVPCNVNQLL	RPA4	41	Q13156
CLVNELARFNRVQPQ	STAU2	11	Q9NUL3
ICFLNIRAKNVAQNP	THAP9	841	Q9H5L6
QALCIPTFQLLEQQN	TNPO3	726	Q9Y5L0
TNVFPVQQLCDINLL	HIVEP1	1501	P15822
RQKEFVAQPNCQQLL	TRPC4	296	Q9UBN4
EIVVFNCSLQQVRNP	TGFBR3	566	Q03167
QLPQIPQFQLACQLL	TNRC6B	1271	Q9UPQ9
VQFCIQRFQLPALQS	NADSYN1	551	Q6IA69