Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF729 ZNF599 KLF12 HNF1A ZNF492 ZNF671 ZNF547 SALL1 ZNF266 ZNF280D FEZF1 ZNF273 ZNF665 ZNF648 MYT1 ZNF329 ZNF516 ZNF667 NFX1 ZNF75D ZNF99 ZNF840P	9.53e-10	1459	67	22	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF729 ZNF599 KLF12 HNF1A ZNF492 ZNF547 SALL1 ZNF266 ZNF280D FEZF1 ZNF273 ZBED6 ZNF665 ZNF648 MYT1 ZNF329 ZNF516 NFX1 ZNF75D ZNF99 ZNF840P	3.31e-09	1412	67	21	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF729 KLF12 HNF1A ZNF492 ZNF671 ZNF547 SALL1 ZNF280D FEZF1 ZNF273 ZNF665 ZNF648 MYT1 ZNF516 ZNF667 ZNF75D ZNF99 ZNF840P	8.91e-08	1244	67	18	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF729 KLF12 HNF1A ZNF492 ZNF671 ZNF547 SALL1 ZNF280D FEZF1 ZNF273 ZNF665 ZNF648 MYT1 ZNF516 ZNF667 ZNF75D ZNF99 ZNF840P	1.23e-07	1271	67	18	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZNF729 KLF12 SALL1 FEZF1 ZBED6 NFX1 ZNF99	9.70e-05	320	67	7	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZNF729 KLF12 SALL1 FEZF1 ZBED6 NFX1 ZNF99	1.09e-04	326	67	7	GO:0001217
GeneOntologyMolecularFunction	zinc ion binding	ZZZ3 ADAMTS4 MYT1 NFX1 EHMT1 ZNF622 ZNF75D CHD4 TNFAIP3 ZMYM6	7.33e-04	891	67	10	GO:0008270
HumanPheno	Ectopic anus	FREM2 SALL1 SETBP1 CHD4 FREM1	6.78e-06	93	16	5	HP:0004397
HumanPheno	Abnormal anus morphology	FREM2 SALL1 SETBP1 EHMT1 CHD4 FREM1	3.74e-05	224	16	6	HP:0034915
HumanPheno	Anteriorly placed anus	SALL1 SETBP1 CHD4 FREM1	4.69e-05	68	16	4	HP:0001545
HumanPheno	Abnormality of the anus	FREM2 SALL1 SETBP1 EHMT1 CHD4 FREM1	6.35e-05	246	16	6	HP:0004378
HumanPheno	Cryptophthalmos	FREM2 FREM1	1.38e-04	6	16	2	HP:0001126
HumanPheno	Ebstein anomaly of the tricuspid valve	MYH7 FREM1	1.38e-04	6	16	2	HP:0010316
HumanPheno	Anal stenosis	FREM2 SALL1 FREM1	1.43e-04	34	16	3	HP:0002025
MousePheno	cryptophthalmos	FREM2 FREM1	2.77e-05	3	43	2	MP:0005242
Domain	zf-C2H2	ZNF729 ZNF599 KLF12 ZNF492 ZNF671 ZNF547 SALL1 ZNF266 ZNF280D FEZF1 ZNF273 ZNF665 ZNF648 ZNF329 ZNF516 ZNF667 ZNF75D ZNF99	1.04e-11	693	64	18	PF00096
Domain	Znf_C2H2-like	ZNF729 ZNF599 KLF12 ZNF492 ZNF671 ZNF547 SALL1 ZNF266 ZNF280D FEZF1 ZNF273 ZNF665 ZNF648 ZNF329 ZNF516 ZNF667 ZNF622 ZNF75D ZNF99	1.06e-11	796	64	19	IPR015880
Domain	Znf_C2H2	ZNF729 ZNF599 KLF12 ZNF492 ZNF671 ZNF547 SALL1 ZNF266 ZNF280D FEZF1 ZNF273 ZNF665 ZNF648 ZNF329 ZNF516 ZNF667 ZNF622 ZNF75D ZNF99	1.29e-11	805	64	19	IPR007087
Domain	ZnF_C2H2	ZNF729 ZNF599 KLF12 ZNF492 ZNF671 ZNF547 SALL1 ZNF266 ZNF280D FEZF1 ZNF273 ZNF665 ZNF648 ZNF329 ZNF516 ZNF667 ZNF622 ZNF75D ZNF99	1.37e-11	808	64	19	SM00355
Domain	ZINC_FINGER_C2H2_2	ZNF729 ZNF599 KLF12 ZNF492 ZNF671 ZNF547 SALL1 ZNF266 ZNF280D FEZF1 ZNF273 ZNF665 ZNF648 ZNF329 ZNF516 ZNF667 ZNF75D ZNF99	6.54e-11	775	64	18	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF729 ZNF599 KLF12 ZNF492 ZNF671 ZNF547 SALL1 ZNF266 ZNF280D FEZF1 ZNF273 ZNF665 ZNF648 ZNF329 ZNF516 ZNF667 ZNF75D ZNF99	6.82e-11	777	64	18	PS00028
Domain	-	ZNF729 ZNF599 KLF12 ZNF492 ZNF671 ZNF547 SALL1 ZNF266 FEZF1 ZNF273 ZNF665 ZNF648 ZNF329 ZNF516 ZNF667 ZNF75D ZNF99	7.76e-11	679	64	17	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF729 ZNF599 KLF12 ZNF492 ZNF671 ZNF547 SALL1 ZNF266 FEZF1 ZNF273 ZNF665 ZNF648 ZNF329 ZNF516 ZNF667 ZNF75D ZNF99	1.09e-10	694	64	17	IPR013087
Domain	KRAB	ZNF729 ZNF599 ZNF492 ZNF671 ZNF547 ZNF266 ZNF273 ZNF667 ZNF75D ZNF99	3.57e-07	358	64	10	PS50805
Domain	KRAB	ZNF729 ZNF599 ZNF492 ZNF671 ZNF547 ZNF266 ZNF273 ZNF667 ZNF75D ZNF99	4.71e-07	369	64	10	SM00349
Domain	KRAB	ZNF729 ZNF599 ZNF492 ZNF671 ZNF547 ZNF266 ZNF273 ZNF667 ZNF75D ZNF99	4.82e-07	370	64	10	IPR001909
Domain	zf-C2H2_6	ZNF729 ZNF492 ZNF671 ZNF266 FEZF1 ZNF273 ZNF329 ZNF667 ZNF99	1.17e-06	314	64	9	PF13912
Domain	KRAB	ZNF729 ZNF599 ZNF492 ZNF671 ZNF547 ZNF273 ZNF667 ZNF75D ZNF99	3.44e-06	358	64	9	PF01352
Domain	Calx_beta	FREM2 FREM1	4.10e-04	9	64	2	IPR003644
Domain	Calx-beta	FREM2 FREM1	4.10e-04	9	64	2	PF03160
Domain	ZnF_BED	ZNF266 ZBED6	6.23e-04	11	64	2	SM00614
Domain	Znf_BED	ZNF266 ZBED6	7.46e-04	12	64	2	IPR003656
Domain	SNF2_N	RAD54B CHD4	5.37e-03	32	64	2	IPR000330
Domain	SNF2_N	RAD54B CHD4	5.37e-03	32	64	2	PF00176
Domain	Helicase_C	RAD54B CHD4 HELQ	5.91e-03	107	64	3	PF00271
Domain	HELICc	RAD54B CHD4 HELQ	5.91e-03	107	64	3	SM00490
Domain	Helicase_C	RAD54B CHD4 HELQ	6.07e-03	108	64	3	IPR001650
Domain	HELICASE_CTER	RAD54B CHD4 HELQ	6.22e-03	109	64	3	PS51194
Domain	HELICASE_ATP_BIND_1	RAD54B CHD4 HELQ	6.22e-03	109	64	3	PS51192
Domain	DEXDc	RAD54B CHD4 HELQ	6.22e-03	109	64	3	SM00487
Domain	Helicase_ATP-bd	RAD54B CHD4 HELQ	6.38e-03	110	64	3	IPR014001
Domain	RAS	DIRAS1 DIRAS2	6.39e-03	35	64	2	PS51421
Domain	Small_GTPase_Ras	DIRAS1 DIRAS2	7.13e-03	37	64	2	IPR020849
Domain	Myosin_head_motor_dom	MYH7 MYO5B	7.51e-03	38	64	2	IPR001609
Domain	MYOSIN_MOTOR	MYH7 MYO5B	7.51e-03	38	64	2	PS51456
Domain	Myosin_head	MYH7 MYO5B	7.51e-03	38	64	2	PF00063
Domain	MYSc	MYH7 MYO5B	7.51e-03	38	64	2	SM00242
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF729 ZNF599 ZNF492 ZNF671 ZNF547 ZNF266 ZNF273 ZNF665 ZNF667 EHMT1 ZNF75D ICE1 CHD4 ZNF99	3.76e-05	1387	43	14	M734
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF729 KLF12 HNF1A SALL1 ZNF280D ZNF665 MYT1 ZNF516 ZNF622 ZNF99	3.73e-06	808	68	10	20412781
Pubmed	A homozygous mutation p.Arg2167Trp in FREM2 causes isolated cryptophthalmos.	FREM2 FREM1	3.77e-06	2	68	2	29688405
Pubmed	Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.	ZZZ3 ZNF280D ZNF516 EHMT1 CHD4	4.81e-06	125	68	5	32891193
Pubmed	Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.	ZNF280D RPS11 EHMT1 CHD4	1.39e-05	74	68	4	29795351
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZZZ3 SALL1 ZNF280D ZNF516 RPS11 ICE1 CHD4	1.78e-05	418	68	7	34709266
Pubmed	The role of FREM2 and FRAS1 in the development of congenital diaphragmatic hernia.	FREM2 FREM1	2.25e-05	4	68	2	29618029
Pubmed	Differential localization profile of Fras1/Frem proteins in epithelial basement membranes of newborn and adult mice.	FREM2 FREM1	2.25e-05	4	68	2	18563433
Pubmed	Deficiency of FRAS1-related extracellular matrix 1 (FREM1) causes congenital diaphragmatic hernia in humans and mice.	FREM2 FREM1	2.25e-05	4	68	2	23221805
Pubmed	Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis.	FREM2 FREM1	2.25e-05	4	68	2	36495293
Pubmed	The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation.	FREM2 SALL1 EGF FREM1	3.72e-05	95	68	4	20843830
Pubmed	Novel frem1-related mouse phenotypes and evidence of genetic interactions with gata4 and slit3.	FREM2 FREM1	3.75e-05	5	68	2	23536828
Pubmed	Spatiotemporal distribution of Fras1/Frem proteins during mouse embryonic development.	FREM2 FREM1	3.75e-05	5	68	2	17251066
Pubmed	Di-Ras, a distinct subgroup of ras family GTPases with unique biochemical properties.	DIRAS1 DIRAS2	3.75e-05	5	68	2	12194967
Pubmed	Basement membrane localization of Frem3 is independent of the Fras1/Frem1/Frem2 protein complex within the sublamina densa.	FREM2 FREM1	3.75e-05	5	68	2	17596926
Pubmed	Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract.	FREM2 FREM1	5.62e-05	6	68	2	24700879
Pubmed	Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue distribution patterns distinct from those of Fras1, Frem2, and QBRICK/Frem1.	FREM2 FREM1	5.62e-05	6	68	2	17462874
Pubmed	A census of human transcription factors: function, expression and evolution.	KLF12 HNF1A ZZZ3 SALL1 ZNF273 MYT1 SETBP1 NFX1 ZNF622	6.72e-05	908	68	9	19274049
Pubmed	Common variants in the trichohyalin gene are associated with straight hair in Europeans.	THADA EGF	1.05e-04	8	68	2	19896111
Pubmed	Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes.	ZNF492 RAD54B NFX1	1.23e-04	49	68	3	17567985
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF729 ZNF665 ZNF99	1.23e-04	49	68	3	9630514
Pubmed	ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions.	ZBED6 ZMYM6	1.68e-04	10	68	2	23533661
Pubmed	The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis.	FREM2 FREM1	1.68e-04	10	68	2	15345741
Pubmed	Functional analysis of the SRY-KRAB interaction in mouse sex determination.	ZNF729 ZNF99	1.68e-04	10	68	2	18588511
Pubmed	The transcription factor GATA-6 regulates pathological cardiac hypertrophy.	MYH7 EGF	1.68e-04	10	68	2	20705924
Pubmed	Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.	ZNF729 ZNF99	2.05e-04	11	68	2	15469996
Pubmed	Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.	ZNF729 ZNF99	2.90e-04	13	68	2	19850934
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	HNF1A ZZZ3 ZNF273 NFX1 EHMT1 CHD4 TNFAIP3 ANKRD55	3.08e-04	877	68	8	20211142
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	ZZZ3 SALL1 EHMT1 CHD4	3.29e-04	167	68	4	20362541
Pubmed	A functionally relevant IRF5 haplotype is associated with reduced risk to Wegener's granulomatosis.	KLF12 TNFAIP3	3.38e-04	14	68	2	20049410
Pubmed	The DNA sequence and analysis of human chromosome 13.	FREM2 KLF12 CCDC168 CKAP2	3.52e-04	170	68	4	15057823
Pubmed	Sprouty1 haploinsufficiency prevents renal agenesis in a model of Fraser syndrome.	FREM2 FREM1	3.89e-04	15	68	2	23064016
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF729 ZNF99	3.89e-04	15	68	2	15885501
Pubmed	Coordinated histone modifications mediated by a CtBP co-repressor complex.	ZNF516 EHMT1	3.89e-04	15	68	2	12700765
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	ZNF516 EHMT1 ICE1 CHD4	4.10e-04	177	68	4	26206133
Pubmed	Human transcription factor protein interaction networks.	SMG1 KLF12 HNF1A EYA4 ZZZ3 SALL1 ZNF516 RPS11 EHMT1 CEP192	4.41e-04	1429	68	10	35140242
Pubmed	Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle.	FREM2 FREM1	4.44e-04	16	68	2	15878328
Pubmed	Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.	FREM2 FREM1	4.44e-04	16	68	2	16880404
Pubmed	Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041.	EGF VAV2	5.65e-04	18	68	2	19531499
Pubmed	Mi-2/NuRD is required in renal progenitor cells during embryonic kidney development.	SALL1 CHD4	5.65e-04	18	68	2	23201013
Pubmed	A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.	FREM2 FREM1	5.65e-04	18	68	2	14730302
Pubmed	Interaction network of human early embryonic transcription factors.	EYA4 ZZZ3 SALL1 ZNF516 EHMT1	6.30e-04	351	68	5	38297188
Pubmed	Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.	HNF1A THADA	7.00e-04	20	68	2	20075150
Pubmed	Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.	ZNF266 ZNF273	7.72e-04	21	68	2	7865130
Pubmed	Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.	HNF1A SALL1	7.72e-04	21	68	2	21300955
Pubmed	PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα.	FREM2 FREM1	7.72e-04	21	68	2	27856617
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	THADA WDR7 ZBED6 RPS11 EHMT1 CHD4 CEP192	8.04e-04	777	68	7	35844135
Pubmed	Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.	TRAM1 TNFAIP3	8.48e-04	22	68	2	23247143
Pubmed	Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes.	HNF1A THADA	8.48e-04	22	68	2	19794065
Pubmed	Sall1 and Sall4 cooperatively interact with Myocd and SRF to promote cardiomyocyte proliferation by regulating CDK and cyclin genes.	MYH7 SALL1	8.48e-04	22	68	2	38014633
Pubmed	Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli.	FREM2 SALL1	9.28e-04	23	68	2	18787044
Pubmed	Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity.	MYT1 CCDC168	9.28e-04	23	68	2	22792062
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	EYA4 SALL1 MYO5B RPS11 EHMT1 CHD4	9.82e-04	583	68	6	29844126
Pubmed	Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice.	EGF FOLH1	1.01e-03	24	68	2	28818950
Pubmed	Histone deacetylases 1 and 2 regulate the transcriptional programs of nephron progenitors and renal vesicles.	HNF1A SALL1	1.19e-03	26	68	2	29712641
Pubmed	Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis.	EHMT1 DIRAS2	1.19e-03	26	68	2	23892084
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	OGFRL1 KLF12 C5orf34 NFX1 FAM216A CEP192 TNFAIP3 CKAP2	1.23e-03	1084	68	8	11544199
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	THADA DIRAS1 ZNF516 NFX1 EHMT1 ICE1 CEP192 TNFAIP3	1.39e-03	1105	68	8	35748872
Pubmed	Analysis of the human HP1 interactome reveals novel binding partners.	ZNF280D CHD4	1.48e-03	29	68	2	21888893
Pubmed	Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.	FREM2 FREM1	1.48e-03	29	68	2	22613833
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF729 ZNF99	1.48e-03	29	68	2	14563677
Pubmed	Isolation and characterization of proteins associated with histone H3 tails in vivo.	EHMT1 CHD4	1.58e-03	30	68	2	17403666
Pubmed	Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.	EGF RAD54B EHMT1	1.59e-03	117	68	3	19124506
Pubmed	Dilated Cardiomyopathy Overview	MYH7 EYA4	1.80e-03	32	68	2	20301486
Pubmed	Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.	ZZZ3 ZNF280D CHD4	1.87e-03	124	68	3	20850016
Pubmed	Lhx2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth.	TNFAIP3 FREM1	1.91e-03	33	68	2	26952977
Pubmed	Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor.	EGF VAV2	1.91e-03	33	68	2	18271526
Interaction	PCBD1 interactions	HNF1A ZZZ3 EHMT1 CHD4 ZMYM6	2.49e-05	104	67	5	int:PCBD1
Interaction	ZMYM2 interactions	KLF12 ZZZ3 ZNF280D ZNF516 EHMT1 C1QTNF1 CHD4	3.21e-05	271	67	7	int:ZMYM2
Interaction	RAD51B interactions	C5orf34 ADAMTS4 CHD4 HELQ	3.35e-05	55	67	4	int:RAD51B
Interaction	RCOR1 interactions	KLF12 ZZZ3 SALL1 MYT1 ZNF516 RPS11 EHMT1 ICE1 CHD4	3.60e-05	494	67	9	int:RCOR1
Interaction	NOL4 interactions	KLF12 ZNF516 CHD4 ZMYM6	4.14e-05	58	67	4	int:NOL4
Cytoband	19q13.43	ZNF671 ZNF547 ZNF329 ZNF667	8.93e-06	87	68	4	19q13.43
Cytoband	6q23	EYA4 TNFAIP3	2.56e-04	16	68	2	6q23
Cytoband	19p12	ZNF729 ZNF492 ZNF99	3.33e-04	90	68	3	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF599 ZNF671 ZNF547 ZNF665 ZNF329 RPS11 ZNF667 LILRA5	3.76e-04	1192	68	8	chr19q13
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF729 ZNF492 ZNF99	8.09e-04	122	68	3	chr19p12
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF729 ZNF599 KLF12 ZNF492 ZNF671 ZNF547 SALL1 ZNF266 FEZF1 ZNF273 ZNF665 ZNF648 ZNF329 ZNF516 ZNF667 ZNF75D ZNF99	7.50e-13	718	46	17	28
GeneFamily	RAS type GTPase family	DIRAS1 DIRAS2	2.81e-03	31	46	2	389
CoexpressionAtlas	kidney_e15.5_Podocyte_MafB_k-means-cluster#2_top-relative-expression-ranked_200	FREM2 EYA4 SALL1 FREM1	7.24e-06	42	63	4	gudmap_kidney_e15.5_Podocyte_MafB_k2_200
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_1000_k-means-cluster#1	FREM2 ARL6IP6 SALL1 FEZF1 ERMN	1.80e-05	109	63	5	Facebase_RNAseq_e9.5_Olfactory Placode_1000_K1
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000	ZNF599 OGFRL1 FREM2 EYA4 SALL1 DIRAS1 ZNF280D MYO5B FEZF1 MYT1 SETBP1 DIRAS2	2.89e-05	989	63	12	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_500_k-means-cluster#4	FREM2 ARL6IP6 SALL1 FEZF1	6.57e-05	73	63	4	Facebase_RNAseq_e9.5_Olfactory Placode_500_K4
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_500	SALL1 DIRAS1 MYO5B FEZF1 MYT1 SETBP1 DIRAS2 ERMN	1.01e-04	493	63	8	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_500
CoexpressionAtlas	kidney_P4_CapMesRenVes_Crym_top-relative-expression-ranked_200	FREM2 EYA4 SALL1 MYO5B FREM1	1.71e-04	175	63	5	gudmap_kidney_P4_CapMesRenVes_Crym_200
CoexpressionAtlas	kidney_P4_CapMesRenVes_Crym_k-means-cluster#4_top-relative-expression-ranked_500	OGFRL1 EYA4 SALL1 FREM1	1.83e-04	95	63	4	gudmap_kidney_P4_CapMesRenVes_Crym_k4_500
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_100	FREM2 SALL1 FEZF1 ERMN	2.14e-04	99	63	4	Facebase_RNAseq_e8.5_Floor Plate_100
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-CALB1--L1-3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FREM2 KLF12 EYA4 MYO5B ANKRD55 VAV2	5.70e-07	200	67	6	f3c710f0fc8a7bfb5371d1aff6e3d8f266953153
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-CALB1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FREM2 KLF12 EYA4 MYO5B ANKRD55 VAV2	5.70e-07	200	67	6	70a06fd7fb8de2c8ec3e3182e4476ced049daeae
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-CALB1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FREM2 KLF12 EYA4 MYO5B ANKRD55 VAV2	5.70e-07	200	67	6	1639982d9d994918f7912d12d9d7cfcbc9da4145
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Granulocytic-Neutrophil-Neu_c3-CST7\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	OR11G2 ZNF516 ZNF75D ANKRD55 LILRA5	4.32e-06	160	67	5	913e59cecf3b1bdd1ef32b4e320042b9bbdb54bc
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FREM2 EYA4 FAM81A VAV2 FREM1	7.87e-06	181	67	5	aa233b652921848af2257cc3687a7a09c3acfb67
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PARP6 ZNF266 ADAMTS4 C1QTNF1 VAV2	1.27e-05	200	67	5	a372ef3f9e6ff6e3c3376d6e10182977c5067788
Disease	Marles Greenberg Persaud syndrome	FREM2 FREM1	4.63e-06	2	64	2	C1855425
Disease	Fraser syndrome (implicated_via_orthology)	FREM2 FREM1	2.77e-05	4	64	2	DOID:0090001 (implicated_via_orthology)
Disease	Unilateral agenesis of kidney	FREM2 FREM1	1.29e-04	8	64	2	C0266294
Disease	colorectal cancer (is_implicated_in)	HNF1A RAD54B CHD4 TNFAIP3	1.41e-04	121	64	4	DOID:9256 (is_implicated_in)
Disease	ankyrin-2 measurement	ZBED6 ATP2B4	2.06e-04	10	64	2	EFO_0021874
Disease	HDL cholesterol change measurement, physical activity	HNF1A FOLH1 LILRA5	3.36e-04	62	64	3	EFO_0003940, EFO_0007805
Disease	urate measurement, bone density	KLF12 SALL1 WDR7 FEZF1 ZNF516 ATP2B4 FREM1	3.81e-04	619	64	7	EFO_0003923, EFO_0004531
Disease	Yu-Zhi constitution type	FREM2 ZNF665	4.77e-04	15	64	2	EFO_0007638
Disease	red blood cell density measurement	KLF12 HNF1A SALL1 RPS11 CHD4 ANKRD55 ATP2B4 LILRA5	6.13e-04	880	64	8	EFO_0007978
Disease	disease free survival	ICE1 CCDC168	6.93e-04	18	64	2	EFO_0000409
Disease	myeloid white cell count	KLF12 HNF1A THADA EGF ZNF516 TNFAIP3 ATP2B4 VAV2	9.21e-04	937	64	8	EFO_0007988
Disease	serum non-albumin protein measurement	EGF ADAMTS4 RPS11 TNFAIP3 ANKRD55	1.13e-03	361	64	5	EFO_0004568
Disease	glucose measurement	HNF1A THADA FOLH1 NFX1 C1QTNF1	1.41e-03	380	64	5	EFO_0004468
Disease	hair morphology	THADA EGF	1.81e-03	29	64	2	EFO_0005038
Disease	Primary familial dilated cardiomyopathy	MYH7 EYA4	1.94e-03	30	64	2	cv:C0340427

Protein segments in the cluster

Peptide	Gene	Start	Entry
NHMMSFHSNRPSKRF	ZNF280D	661	Q6N043
SAPHHMAQRSQKSRS	ANKRD55	461	Q3KP44
KPYNQKSIHSFMTHP	ATP2B4	1156	P23634
HMTLSQAFHLKNNSK	CKAP2	141	Q8WWK9
HHQKSNSLKPLSMSQ	RAD54B	856	Q9Y620
FKKDNPEHTMSHINF	PGBD4	471	Q96DM1
QSTKLKMSHRDSNHQ	FAM81A	196	Q8TBF8
NKLMTNLRSTHPHFV	MYH7	656	P12883
PLASSHNSQTSMHKK	OGFRL1	331	Q5TC84
KNKARFSIPSMTEHH	LILRA5	96	A6NI73
FTLTQAPKHGHMRVS	FREM2	866	Q5SZK8
NFSTQKVKMHIHSTN	FOLH1	336	Q04609
QKHAPVHSFSMELLK	FREM1	1216	Q5H8C1
NSKKSHSFPPMNRDH	NFX1	1016	Q12986
QSHLSQHLNKGTPMK	HNF1A	141	P20823
GFRKPSQADMLHSKH	ERMN	161	Q8TAM6
HQFPAMQRLSISKGH	DIRAS1	66	O95057
MAAAAKAFKHPSIRN	ADAMTS4	246	O75173
AKKHNMPFWRISSHS	EYA4	611	O95677
HEQKTSHQLQKAMPF	ICE1	811	Q9Y2F5
AAFSVGRKKPMHSNH	C1QTNF1	146	Q9BXJ1
SKHPTQHNLFAMSLF	EGF	241	P01133
HQFPAMQRLSISKGH	DIRAS2	66	Q96HU8
PFKAALRSKMTFHIH	DNAAF9	416	Q5TEA3
PHMKHTLRFQLSGQS	CEP192	2376	Q8TEP8
SPMNLQSNKLSHVHR	KLF12	171	Q9Y4X4
SKHKHQKDSPLASNM	CCDC168	6481	Q8NDH2
MQLPEHKKHATDFAT	HELQ	131	Q8TDG4
KRQYMHVLQHSSQKP	FAM216A	131	Q8WUB2
SHQHLSKESMAGNKP	CHD4	1831	Q14839
SLALHFHNKISNMSK	C5orf34	256	Q96MH7
MSRRKQAKPQHFQSD	SALL1	1	Q9NSC2
FKMEHQNKRSPLHAA	EHMT1	766	Q9H9B1
IHRHMKIFNSPSNSS	OR11G2	31	Q8NGC1
KLPLSRLKFMHTSHQ	PARP6	431	Q2NL67
HHINNMKPSFTRENT	MT-ND4	421	P03905
RFEKRHKNMSVHLSP	RPS11	101	P62280
QTKLPMFLHCRNSHA	TATDN1	141	Q6P1N9
MFRNHKSHLKSQTAE	THADA	501	Q6YHU6
NLTFHMHTHNDKKPF	FEZF1	386	A0PJY2
RSHMSKAPSNTFHPQ	SMG1	846	Q96Q15
SPARFKKLTGHSFHM	ARL6IP6	191	Q8N6S5
NHMKNFSESPKFRSL	C12orf42	66	Q96LP6
KAFSMHSNLTKHQII	ZNF665	381	Q9H7R5
AFNQMSSLLLHKKIH	ZNF667	261	Q5HYK9
KSFPFQSSLSQHMRK	ZNF516	41	Q92618
FNNSSTLMKHKIIHT	ZNF99	266	A8MXY4
FNNSSTLMKHKIIHT	ZNF99	546	A8MXY4
FDNTPNFSRHKRNHM	ZNF273	551	Q14593
SSFIQHNMTHTREKP	ZNF599	296	Q96NL3
LLQHQASLSSMKPHK	ZNF671	256	Q8TAW3
KPTNGIIHHFKTMHR	TNFAIP3	31	P21580
FNRPSKVIQHQSMHS	ZNF840P	216	A6NDX5
KAFNQSSHLTTHKMI	ZNF492	456	Q9P255
KNSHFHPKQIMSLDF	ZBED6	921	P86452
NRRMHFSKTKHSKFN	TRAM1	106	Q15629
SDLNKHFMTHQGIKP	ZNF75D	406	P51815
SSENMKPANLSHHLK	ZMYM6	776	O95789
PTFVKNHRVHMAGKT	ZNF547	141	Q8IVP9
RKHQRNMHSNNKPFP	ZNF648	351	Q5T619
KNVAHMTKDHSFFIP	ZNF622	266	Q969S3
MSNIKPDKANANHHS	VAV2	511	P52735
LKPKHQQKSSSQNHM	SETBP1	206	Q9Y6X0
SLAALKNMAHHKLQT	WDR7	636	Q9Y4E6
LNKHLFKPSTFMTSH	ZZZ3	736	Q8IYH5
FNHFTSLGHQKIMKR	ZNF329	156	Q86UD4
AFNSFSALMKHKVIH	ZNF729	776	A6NN14
LNNHMRTHSAKKPFT	ZNF266	451	Q14584
RHSSSQHFQKPRMSN	MYO5B	531	Q9ULV0
LSMHKHRKRENAFPS	MYT1	671	Q01538