Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	brain development	TTBK2 IGF1R PSEN1 MBP DVL3 FRS2 IKZF1 ATOH1 MED1 SHROOM2 PCNT	4.46e-05	859	62	11	GO:0007420
GeneOntologyBiologicalProcess	U2-type prespliceosome assembly	SNIP1 HTATSF1 BUD13	5.67e-05	25	62	3	GO:1903241
GeneOntologyBiologicalProcess	head development	TTBK2 IGF1R PSEN1 MBP DVL3 FRS2 IKZF1 ATOH1 MED1 SHROOM2 PCNT	8.18e-05	919	62	11	GO:0060322
GeneOntologyBiologicalProcess	mRNA splicing, via spliceosome	SNIP1 RBMXL3 HTATSF1 ACIN1 BUD13 CWC25 CWF19L1	9.69e-05	358	62	7	GO:0000398
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	SNIP1 RBMXL3 HTATSF1 ACIN1 BUD13 CWC25 CWF19L1	9.69e-05	358	62	7	GO:0000377
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions	SNIP1 RBMXL3 HTATSF1 ACIN1 BUD13 CWC25 CWF19L1	1.04e-04	362	62	7	GO:0000375
GeneOntologyBiologicalProcess	RNA splicing	SNIP1 RBMXL3 ZC3H13 HTATSF1 ACIN1 BUD13 CWC25 CWF19L1	1.24e-04	502	62	8	GO:0008380
GeneOntologyCellularComponent	spliceosomal complex	SNIP1 RBMXL3 HTATSF1 BUD13 CWC25 CWF19L1	3.83e-05	215	61	6	GO:0005681
GeneOntologyCellularComponent	U2 snRNP	SNIP1 HTATSF1 BUD13	7.35e-05	28	61	3	GO:0005686
GeneOntologyCellularComponent	U2-type spliceosomal complex	SNIP1 HTATSF1 BUD13 CWC25	1.86e-04	97	61	4	GO:0005684
GeneOntologyCellularComponent	nuclear protein-containing complex	SNIP1 PBRM1 RBMXL3 BAZ1B HTATSF1 ACIN1 BUD13 XPC MED1 CWC25 HCFC1 CWF19L1	5.43e-04	1377	61	12	GO:0140513
Domain	Furin_repeat	IGF1R FURIN	1.55e-03	18	61	2	IPR006212
Domain	FU	IGF1R FURIN	1.55e-03	18	61	2	SM00261
Domain	Bromodomain_CS	PBRM1 BAZ1B	3.24e-03	26	61	2	IPR018359
Domain	ig	CD33 OBSCN KIR2DL5A KIR3DS1	3.45e-03	190	61	4	PF00047
Domain	Immunoglobulin	CD33 OBSCN KIR2DL5A KIR3DS1	3.45e-03	190	61	4	IPR013151
Domain	FHA	SNIP1 MKI67	3.76e-03	28	61	2	SM00240
Domain	FHA_DOMAIN	SNIP1 MKI67	4.59e-03	31	61	2	PS50006
Domain	FHA	SNIP1 MKI67	4.59e-03	31	61	2	PF00498
Domain	-	IGF1R CD33 OBSCN NRG2 KIR2DL5A KIR3DS1 HCFC1	5.70e-03	663	61	7	2.60.40.10
Domain	FHA_dom	SNIP1 MKI67	6.15e-03	36	61	2	IPR000253
Domain	-	SNIP1 MKI67	6.15e-03	36	61	2	2.60.200.20
Domain	BROMODOMAIN_1	PBRM1 BAZ1B	6.49e-03	37	61	2	PS00633
Domain	Bromodomain	PBRM1 BAZ1B	6.84e-03	38	61	2	PF00439
Domain	BROMODOMAIN_2	PBRM1 BAZ1B	7.93e-03	41	61	2	PS50014
Domain	Ig-like_fold	IGF1R CD33 OBSCN NRG2 KIR2DL5A KIR3DS1 HCFC1	7.95e-03	706	61	7	IPR013783
Domain	BROMO	PBRM1 BAZ1B	8.31e-03	42	61	2	SM00297
Domain	Bromodomain	PBRM1 BAZ1B	8.31e-03	42	61	2	IPR001487
Domain	-	PBRM1 BAZ1B	8.31e-03	42	61	2	1.20.920.10
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SNIP1 ZC3H13 BAZ1B ACIN1 BUD13 XPC HCFC1 PCNT	1.59e-08	251	62	8	31076518
Pubmed	Killer-cell immunoglobulin-like receptors (KIR) in severe A (H1N1) 2009 influenza infections.	KIR2DL5B KIR2DL5A KIR3DS1	2.16e-08	4	62	3	22652695
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	MKI67 BAZ1B ACIN1 IKZF1 XPC HCFC1	2.71e-07	148	62	6	32538781
Pubmed	Different KIRs confer susceptibility and protection to adults with latent autoimmune diabetes in Latvian and Asian Indian populations.	KIR2DL5B KIR2DL5A KIR3DS1	1.52e-06	13	62	3	19120281
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PLEKHG4B CABLES2 IGF1R MYO5A PTPRN2 MYT1 MBP OBSCN MAGI3 SHROOM2 SNX29 LRRC41 PCNT	1.80e-06	1489	62	13	28611215
Pubmed	Insulin-like growth factor signaling regulates the timing of sensory cell differentiation in the mouse cochlea.	IGF1R MKI67 ATOH1	1.94e-06	14	62	3	22159122
Pubmed	PBAF Subunit Pbrm1 Selectively Influences the Transition from Progenitors to Pre-Myelinating Cells during Oligodendrocyte Development.	PBRM1 MBP MKI67	2.42e-06	15	62	3	37371026
Pubmed	Variants in Notch signalling pathway genes, PSEN1 and MAML2, predict overall survival in Chinese patients with epithelial ovarian cancer.	PSEN1 MAML2	3.13e-06	2	62	2	30055028
Pubmed	Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B.	KIR2DL5B KIR2DL5A	3.13e-06	2	62	2	12185535
Pubmed	Gene structure and promoter variation of expressed and nonexpressed variants of the KIR2DL5 gene.	KIR2DL5B KIR2DL5A	3.13e-06	2	62	2	11086080
Pubmed	Association of KIR2DL5B gene with celiac disease supports the susceptibility locus on 19q13.4.	KIR2DL5B KIR2DL5A	3.13e-06	2	62	2	17215859
Pubmed	Novel myosin heavy chain encoded by murine dilute coat colour locus.	MYO5A MBP	3.13e-06	2	62	2	1996138
Pubmed	Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells.	IGF1R FURIN	3.13e-06	2	62	2	18064302
Pubmed	Gene therapy for Alzheimer's disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation.	PSEN1 CD33	3.13e-06	2	62	2	32803224
Pubmed	Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection.	KIR2DL5B KIR2DL5A KIR3DS1	3.60e-06	17	62	3	20878400
Pubmed	Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China.	KIR2DL5B KIR2DL5A KIR3DS1	3.60e-06	17	62	3	20650299
Pubmed	[Analysis of natural killer cell immunoglobulin-like receptor genes in Chinese].	KIR2DL5B KIR2DL5A KIR3DS1	3.60e-06	17	62	3	19218127
Pubmed	Killer cell immunoglobulin-like receptor gene polymorphisms in patients with leukemia: possible association with susceptibility to the disease.	KIR2DL5B KIR2DL5A KIR3DS1	3.60e-06	17	62	3	19450876
Pubmed	Distribution of killer-cell immunoglobulin-like receptor genes in Eastern mainland Chinese Han and Taiwanese Han populations.	KIR2DL5B KIR2DL5A KIR3DS1	3.60e-06	17	62	3	19761533
Pubmed	Role of the Pbrm1 subunit and the PBAF complex in Schwann cell development.	PBRM1 MBP MKI67	5.12e-06	19	62	3	35173232
Pubmed	Compound KIR-HLA genotype analyses in the Iranian population by a novel PCR-SSP assay.	KIR2DL5B KIR2DL5A KIR3DS1	6.02e-06	20	62	3	20193031
Pubmed	HLA and KIR frequencies in Sicilian Centenarians.	KIR2DL5B KIR2DL5A KIR3DS1	6.02e-06	20	62	3	20426625
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	STOX2 EXPH5 MKI67 DVL3 FRS2 CRYBG3	7.62e-06	263	62	6	34702444
Pubmed	Distribution of KIR genes in the population of unrelated individuals homozygous for ancestral haplotype AH8.1 (HLA-A1B8DR3).	KIR2DL5B KIR2DL5A KIR3DS1	8.11e-06	22	62	3	20492596
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	PBRM1 TRIM25 MKI67 ACIN1 MED1 HCFC1	9.03e-06	271	62	6	32433965
Pubmed	Polymorphisms of KIRs gene and HLA-C alleles in patients with ankylosing spondylitis: possible association with susceptibility to the disease.	KIR2DL5A KIR3DS1	9.37e-06	3	62	2	18297378
Pubmed	Lipoic acid-induced oxidative stress abrogates IGF-1R maturation by inhibiting the CREB/furin axis in breast cancer cell lines.	IGF1R FURIN	9.37e-06	3	62	2	32060422
Pubmed	Killer immunoglobulin-like receptor genotype may distinguish immunodeficient HIV-infected patients resistant to immune restoration diseases associated with herpes virus infections.	KIR2DL5A KIR3DS1	9.37e-06	3	62	2	17592337
Pubmed	Promoter variants of KIR2DL5 add to diversity and may impact gene expression.	KIR2DL5B KIR2DL5A	9.37e-06	3	62	2	18461314
Pubmed	The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK⁺ T-cell lymphoma.	IGF1R IKZF1	9.37e-06	3	62	2	25884514
Pubmed	Structural and functional modularity of the U2 snRNP in pre-mRNA splicing.	SNIP1 HTATSF1 BUD13	1.06e-05	24	62	3	31744343
Pubmed	MEK Is a Key Regulator of Gliogenesis in the Developing Brain.	MBP MKI67 ATOH1	1.06e-05	24	62	3	22998872
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	PBRM1 TRIM25 RNF168 MKI67 BAZ1B HTATSF1 ACIN1 MED1 HCFC1 CWF19L1	1.15e-05	1014	62	10	32416067
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	PBRM1 RNF168 MKI67 BAZ1B XPC MED1 HCFC1 LRRC41	1.23e-05	608	62	8	36089195
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SNIP1 PBRM1 RNF168 ZC3H13 MKI67 BAZ1B HTATSF1 ACIN1 XPC MED1 HCFC1	1.61e-05	1294	62	11	30804502
Pubmed	The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.	MKI67 DVL3 BAZ1B HCFC1	1.74e-05	86	62	4	37253089
Pubmed	Killer immunoglobulin-like receptor gene repertoire influences viral load of primary human cytomegalovirus infection in renal transplant patients.	KIR2DL5A KIR3DS1	1.87e-05	4	62	2	25253288
Pubmed	Structural and biochemical studies of RIG-I antiviral signaling.	TRIM25 MBP	1.87e-05	4	62	2	23264040
Pubmed	KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains.	KIR2DL5B KIR2DL5A	1.87e-05	4	62	2	10820258
Pubmed	Activating KIR genes are associated with ankylosing spondylitis in Asian populations.	KIR2DL5A KIR3DS1	1.87e-05	4	62	2	18638658
Pubmed	Myosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cells.	MYO5A PTPRN2	1.87e-05	4	62	2	15788565
Pubmed	Embryonic expression of pericentrin suggests universal roles in ciliogenesis.	MKI67 PCNT	1.87e-05	4	62	2	16534625
Pubmed	Biochemical and cellular characterization of transcription factors binding to the hyperconserved core promoter-associated M4 motif.	IKZF1 HCFC1	1.87e-05	4	62	2	27576892
Pubmed	Recombinant structures expand and contract inter and intragenic diversification at the KIR locus.	KIR2DL5A KIR3DS1	1.87e-05	4	62	2	23394822
Pubmed	Investigation of killer cell immunoglobulin-like receptor (KIR) gene diversity: KIR2DL2, KIR2DL5 and KIR2DS5.	KIR2DL5B KIR2DL5A	1.87e-05	4	62	2	18498296
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	PBRM1 MYO5A ZC3H13 MKI67 BAZ1B ACIN1 HCFC1 PCNT	2.05e-05	653	62	8	22586326
Pubmed	USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c.	TRIM25 MKI67 BAZ1B ACIN1	2.09e-05	90	62	4	35654790
Pubmed	A comprehensive resource of interacting protein regions for refining human transcription factor networks.	IGF1R ZC3H13 BAZ1B ACIN1 CWC25	2.38e-05	191	62	5	20195357
Pubmed	KIR gene in ethnic and Mestizo populations from Mexico.	KIR2DL5A KIR3DS1	3.12e-05	5	62	2	16698429
Pubmed	Involvement of the cytoplasmic C-terminal domain of connexin43 in neuronal migration.	MBP MKI67	3.12e-05	5	62	2	19228955
Pubmed	Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions.	MYO5A EXPH5	3.12e-05	5	62	2	12062444
Pubmed	Dual regulation of planar polarization by secreted Wnts and Vangl2 in the developing mouse cochlea.	DVL3 ATOH1 PCNT	3.39e-05	35	62	3	32907846
Pubmed	Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis.	KIR2DL5B KIR2DL5A KIR3DS1	3.39e-05	35	62	3	19683555
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	PBRM1 MKI67 BAZ1B ACIN1	3.55e-05	103	62	4	32744500
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	TRIM25 MKI67 BAZ1B HTATSF1 ACIN1 MED1 HCFC1 SNX29 PCNT	3.96e-05	934	62	9	33916271
Pubmed	Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis.	GLDN IGF1R MKI67	4.01e-05	37	62	3	35974052
Pubmed	WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis.	MKI67 KATNA1 PCNT	4.35e-05	38	62	3	34059773
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	ZC3H13 MKI67 BAZ1B HTATSF1 ACIN1 BUD13 MED1 CWC25 HCFC1	4.67e-05	954	62	9	36373674
Pubmed	Late embryonic and postnatal development of interstitial cells of cajal in mouse esophagus: distribution, proliferation and kit dependence.	IGF1R MKI67	4.67e-05	6	62	2	22269660
Pubmed	Nav2 hypomorphic mutant mice are ataxic and exhibit abnormalities in cerebellar development.	MKI67 ATOH1	4.67e-05	6	62	2	21419114
Pubmed	Killer cell immunoglobulin-like receptor gene polymorphism in lymphoproliferative diseases of granular lymphocytes in a Japanese population.	KIR2DL5A KIR3DS1	4.67e-05	6	62	2	20528243
Pubmed	STAT3 Controls the Long-Term Survival and Phenotype of Repair Schwann Cells during Nerve Regeneration.	MBP MKI67	4.67e-05	6	62	2	28320842
Pubmed	The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator.	MED1 HCFC1	4.67e-05	6	62	2	14983011
Pubmed	Generation of BAF53b-Cre transgenic mice with pan-neuronal Cre activities.	MBP MKI67	4.67e-05	6	62	2	26077106
Pubmed	Asynchrony of Apical Polarization, Luminogenesis, and Functional Differentiation in the Developing Thyroid Gland.	MKI67 PCNT	4.67e-05	6	62	2	34975747
Pubmed	DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC.	PBRM1 MKI67 BAZ1B PCNT	6.03e-05	118	62	4	37105989
Pubmed	Upregulation of neurovascular communication through filamin abrogation promotes ectopic periventricular neurogenesis.	IGF1R MKI67 PCNT	6.33e-05	43	62	3	27664421
Pubmed	Compensatory embryonic response to allele-specific inactivation of the murine X-linked gene Hcfc1.	MKI67 HCFC1	6.53e-05	7	62	2	26921005
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	ZC3H13 MKI67 HTATSF1 ACIN1 MED1 HCFC1	7.85e-05	399	62	6	35987950
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	PBRM1 HTATSF1 IKZF1 HCFC1	8.53e-05	129	62	4	23022380
Pubmed	Functional proteomics mapping of a human signaling pathway.	SNIP1 PBRM1 RNF168 EXPH5 DVL3 HTATSF1 XPC	8.65e-05	591	62	7	15231748
Pubmed	KIR haplotype content at the allele level in 77 Northern Irish families.	KIR2DL5A KIR3DS1	8.69e-05	8	62	2	17200871
Pubmed	The epigenetic modifier PBRM1 restricts the basal activity of the innate immune system by repressing retinoic acid-inducible gene-I-like receptor signalling and is a potential prognostic biomarker for colon cancer.	PBRM1 TRIM25	8.69e-05	8	62	2	28940253
Pubmed	Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth.	IGF1R ATOH1	8.69e-05	8	62	2	31983537
Pubmed	Primary cilia control oligodendrocyte precursor cell proliferation in white matter injury via Hedgehog-independent CREB signaling.	MBP MKI67	8.69e-05	8	62	2	37858465
Pubmed	Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling.	MBP FRS2	8.69e-05	8	62	2	10383403
Pubmed	In vivo evidence for unbiased Ikaros retinal lineages using an Ikaros-Cre mouse line driving clonal recombination.	MKI67 IKZF1	1.12e-04	9	62	2	23074133
Pubmed	Patched2 modulates tumorigenesis in patched1 heterozygous mice.	MKI67 ATOH1	1.12e-04	9	62	2	16849540
Pubmed	Polymorphisms of killer cell immunoglobulin-like receptor gene: possible association with susceptibility to or clearance of hepatitis B virus infection in Chinese Han population.	KIR2DL5A KIR3DS1	1.12e-04	9	62	2	18074414
Pubmed	Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor alpha expression.	MBP MKI67	1.12e-04	9	62	2	18184726
Pubmed	A protein interaction landscape of breast cancer.	TRIM25 PSEN1 MYO5A MKI67 ACIN1 MUC5B XPC	1.34e-04	634	62	7	34591612
Pubmed	gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis.	PSEN1 MKI67	1.39e-04	10	62	2	15525534
Pubmed	Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia.	MKI67 ATOH1	1.39e-04	10	62	2	18652815
Pubmed	Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus.	KIR2DL5B KIR3DS1	1.39e-04	10	62	2	21206914
Pubmed	Macrophage-derived IGF-1 protects the neonatal intestine against necrotizing enterocolitis by promoting microvascular development.	IGF1R MKI67	1.39e-04	10	62	2	35388142
Pubmed	ASCL1 regulates proliferation of NG2-glia in the embryonic and adult spinal cord.	MBP MKI67	1.39e-04	10	62	2	29683222
Pubmed	Dlx2 progenitor migration in wild type and Nkx2.1 mutant telencephalon.	MBP MKI67	1.39e-04	10	62	2	12902388
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	SNIP1 PBRM1 TRIM25 RBMXL3 MKI67 ACIN1 XPC MED1 CWC25 HCFC1	1.46e-04	1371	62	10	36244648
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	MKI67 BAZ1B ACIN1 MED1 HCFC1	1.53e-04	283	62	5	30585729
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	PBRM1 HTATSF1 XPC HCFC1	1.53e-04	150	62	4	28242625
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	MBP HTATSF1 KATNA1 HCFC1 ZFP62 LRRC41	1.53e-04	451	62	6	36168627
Pubmed	The cerebrospinal fluid provides a proliferative niche for neural progenitor cells.	IGF1R MKI67	1.70e-04	11	62	2	21382550
Pubmed	Gli3 is required for maintenance and fate specification of cortical progenitors.	MBP MKI67	1.70e-04	11	62	2	21525285
Pubmed	Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk.	MBP FRS2	1.70e-04	11	62	2	10464310
Pubmed	Olig2-dependent developmental fate switch of NG2 cells.	MBP MKI67	1.70e-04	11	62	2	22627280
Pubmed	Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system.	MKI67 ATOH1	1.70e-04	11	62	2	11032813
Pubmed	Natural killer cells and immune surveillance.	KIR2DL5A KIR3DS1	1.70e-04	11	62	2	18830515
Pubmed	SoxC transcription factors shape the epigenetic landscape to establish competence for sensory differentiation in the mammalian organ of Corti.	MKI67 ATOH1	1.70e-04	11	62	2	37585469
Pubmed	Identification of a candidate gene for astigmatism.	XYLT1 MAML2	1.70e-04	11	62	2	23322567
Pubmed	Atoh1 drives the heterogeneity of the pontine nuclei neurons and promotes their differentiation.	MKI67 ATOH1	1.70e-04	11	62	2	37390208
Interaction	NOTCH1 interactions	PBRM1 TRIM25 PSEN1 FURIN HTATSF1 IKZF1 MAML2 HCFC1	7.05e-06	345	59	8	int:NOTCH1
Interaction	SMARCD2 interactions	SNIP1 PBRM1 TRIM25 MKI67 BAZ1B IKZF1	1.56e-05	183	59	6	int:SMARCD2
Interaction	ANKRD50 interactions	SNIP1 ZC3H13 BAZ1B BUD13 CWC25	1.60e-05	108	59	5	int:ANKRD50
Interaction	GAGE5 interactions	SNIP1 MYO5A ZC3H13 CWC25	1.61e-05	52	59	4	int:GAGE5
Interaction	CTBP1 interactions	IGF1R TRIM25 MARCHF10 FURIN DVL3 IKZF1 MAML2 MED1	2.29e-05	406	59	8	int:CTBP1
Interaction	SUPT16H interactions	SNIP1 TRIM25 ZC3H13 FURIN BAZ1B ACIN1 XPC MED1	4.18e-05	442	59	8	int:SUPT16H
Interaction	TDG interactions	SNIP1 TRIM25 IKZF1 XPC	4.97e-05	69	59	4	int:TDG
Interaction	USP53 interactions	TRIM25 MKI67 BAZ1B ACIN1 HCFC1	5.21e-05	138	59	5	int:USP53
Interaction	NCK1 interactions	IGF1R SCARF2 MBP FRS2 BAZ1B SHROOM2	7.80e-05	244	59	6	int:NCK1
Interaction	ADARB1 interactions	PBRM1 TRIM25 MKI67 ACIN1 BUD13 MED1 HCFC1 ZFP62	8.49e-05	489	59	8	int:ADARB1
Interaction	BRD3 interactions	SNIP1 PBRM1 TRIM25 MKI67 BAZ1B ACIN1 BUD13 MED1	9.11e-05	494	59	8	int:BRD3
Cytoband	17q23.2	TRIM25 MARCHF10	9.22e-04	33	62	2	17q23.2
GeneFamily	CD molecules\|Killer cell immunoglobulin like receptors	KIR2DL5B KIR2DL5A KIR3DS1	1.15e-05	18	45	3	620
GeneFamily	CD molecules\|Mucins	MUC5B MUC12	1.23e-03	21	45	2	648
GeneFamily	PDZ domain containing	DVL3 MAGI3 SHROOM2	6.38e-03	152	45	3	1220
Coexpression	GSE8621_UNSTIM_VS_LPS_PRIMED_AND_LPS_STIM_MACROPHAGE_DN	TRIM25 CD33 IKZF1 CRYBG3 MED1 KIF17	6.97e-06	199	61	6	M6987
Disease	oleoyl-oleoyl-glycerol (18:1/18:1) [1] measurement	BAZ1B BUD13	5.47e-05	6	57	2	EFO_0800497
Disease	Peripheral Nervous System Diseases	IGF1R MYO5A MKI67	1.58e-04	54	57	3	C4721453
Disease	oleoyl-linoleoyl-glycerol (18:1/18:2) [1] measurement	BAZ1B BUD13	1.99e-04	11	57	2	EFO_0800332
Disease	Hypertriglyceridemia	BAZ1B BUD13	6.14e-04	19	57	2	EFO_0004211
Disease	kidney disease (biomarker_via_orthology)	XYLT1 MKI67	7.52e-04	21	57	2	DOID:557 (biomarker_via_orthology)
Disease	Acute Confusional Senile Dementia	IGF1R PSEN1 CD33	9.40e-04	99	57	3	C0546126
Disease	Alzheimer's Disease, Focal Onset	IGF1R PSEN1 CD33	9.40e-04	99	57	3	C0750900
Disease	Alzheimer Disease, Early Onset	IGF1R PSEN1 CD33	9.40e-04	99	57	3	C0750901
Disease	Presenile dementia	IGF1R PSEN1 CD33	9.40e-04	99	57	3	C0011265
Disease	Alzheimer Disease, Late Onset	IGF1R PSEN1 CD33	9.40e-04	99	57	3	C0494463
Disease	Familial Alzheimer Disease (FAD)	IGF1R PSEN1 CD33	9.68e-04	100	57	3	C0276496
Disease	Alzheimer's Disease	IGF1R PSEN1 CD33	9.96e-04	101	57	3	C0002395
Disease	diabetes mellitus (implicated_via_orthology)	IGF1R PTPRN2	1.16e-03	26	57	2	DOID:9351 (implicated_via_orthology)
Disease	pancreatic cancer (is_implicated_in)	IGF1R MKI67 XPC	1.34e-03	112	57	3	DOID:1793 (is_implicated_in)
Disease	neuroblastoma, cutaneous melanoma	MAGI3 SNX29	1.34e-03	28	57	2	EFO_0000389, EFO_0000621
Disease	longevity, healthspan, parental longevity	FURIN MAGI3	1.44e-03	29	57	2	EFO_0004300, EFO_0007796, EFO_0009762
Disease	total blood protein measurement	CABLES2 TRIM25 RNF168 IKZF1 MAML2	1.74e-03	449	57	5	EFO_0004536
Disease	hyperuricemia	IGF1R BAZ1B	1.86e-03	33	57	2	EFO_0009104

Protein segments in the cluster

Peptide	Gene	Start	Entry
PDSSGSRSHSPLRSK	ACIN1	596	Q9UKV3
RSHRGPSERSHCSPS	C2orf16	1676	Q68DN1
TCHSPSERSHRSPSG	C2orf16	1876	Q68DN1
HDTPDSSPRRVRHGT	BUD13	121	Q9BRD0
RSSSHSPPRHASKKS	CWC25	261	Q9NXE8
SEVSPGHHGPRKSRD	CRYBG3	2101	Q68DQ2
NSGGTPRTSSKPHKH	BAZ1B	456	Q9UIG0
PASSARNKRSHSGEP	GLDN	86	Q6ZMI3
PSERSGPAASEHSHR	DVL3	621	Q92997
THGRSLSPSSPHTVR	MUC5B	4011	Q9HC84
EASSPARPSKHSVGS	PTPRN2	121	Q92932
PTEPSSKTGIRRHLH	KIR2DL5A	226	Q8N109
SSPSIKDLPAGRHSH	HCFC1	1221	P51610
DGHHSVSTPGPSRKR	PBRM1	21	Q86U86
VSKRDPPSSHGHSNK	MAGI3	1191	Q5TCQ9
RNDTHPTTGSASPKH	CD33	296	P20138
RASGHPKPHSRSSSA	GPR50	381	Q13585
KRSSTGRDSKSSPHP	CWF19L1	301	Q69YN2
SSSLPLPDRHSGHKA	IGF1R	1311	P08069
PTEPSSKTGIRRHLH	KIR2DL5B	226	Q8NHK3
SHSTRASSRHSRGPP	NRG2	826	O14511
HPPKVRERHFSESTS	EXPH5	1811	Q8NEV8
RTSGETTHTHREPAG	MKI67	1046	P46013
HKPLAEGTPRSNHSA	IKZF1	351	Q13422
KGISPAHKTSTPTHR	OSBPL6	6	Q9BZF3
RHQSHTAEAGPRKSP	PCNT	2201	O95613
PSRARHFSEHPSTSK	HTATSF1	396	O43719
DSKTPSASPRHGRSR	OBSCN	5566	Q5VST9
RKTNTLPSHTHSPGN	MAML2	241	Q8IZL2
VHGLHEKEPSSSPRT	FRMD1	421	Q8N878
SHPSSRHPSVGSARL	FRS2	161	Q8WU20
GVTKRSLSPHRPRHS	FURIN	71	P09958
SPRSHRSDGEFSPHS	ATOH1	331	Q92858
PSHHKRSRFGGTSTP	MARCHF10	311	Q8NA82
PKRGSGKDSHHPART	MBP	186	P02686
SDPKSHGNRPSTTVR	KATNA1	121	O75449
APAQRTKHTSGSPRH	CABLES2	141	Q9BTV7
ISGSTPKHERGSPSH	MED1	1436	Q15648
ARKSLTHHNSPPGLS	KIF17	966	Q9P2E2
PASSTRHTSFKRHLP	SYT6	166	Q5T7P8
TKERSTVSLPAHRHP	SLC4A11	301	Q8NBS3
SPRSKRNRSPHHSTV	SNIP1	91	Q8TAD8
SSGRKHRGHSESPEK	SNX29	361	Q8TEQ0
SHLGPHRSTPESRAA	PSEN1	346	P49768
ATSHEAPGTKRSPSA	LRRC41	346	Q15345
PTEPSSKSGNLRHLH	KIR3DS1	326	Q14943
RPQHVHGRSRSSPST	SHROOM2	911	Q13796
GSATTRHPEPRRTEH	CLEC1A	26	Q8NC01
HISRHTRPKGQPLSS	C12orf42	191	Q96LP6
NSSHGKDVSRPPHAR	XYLT1	226	Q86Y38
PHKRATPSSLAHSVG	RBMXL3	161	Q8N7X1
SSSDHAAPFKRPHST	PLEKHG4B	1176	Q96PX9
PEPSRGSSHSKVHRS	STOX2	456	Q9P2F5
PSDKSAHTVEHGSPR	SCARF2	706	Q96GP6
GEHDPASTHKSTRPV	TRIM25	366	Q14258
SSPHLGRSKSPPSHS	TTBK2	1181	Q6IQ55
RSSPPKAAGHRSHKR	nan	236	A8MX80
RQTHTKHPTPERGSR	RNF168	501	Q8IYW5
SSLINHKSTHPGRTP	ZFP62	686	Q8NB50
RTRGSPHPTSNHWKS	USP30	206	Q70CQ3
THRGSHRKDPSLPAA	XPC	486	Q01831
RDKPRSTSPAGQHHS	ZC3H13	311	Q5T200
EKSTTSHSRPGPTHT	MUC12	306	Q9UKN1
PKPGHKRTDSTHSSN	MYO5A	1106	Q9Y4I1
HRPETAEGRSPVKSH	MYT1	126	Q01538