Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein serine kinase activity	NEK3 TRIO KALRN UHMK1 NIM1K PRKCI LRRK1 MAP2K3 MAP2K6	1.46e-05	363	80	9	GO:0106310
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	NEK3 TRIO KALRN UHMK1 NIM1K BAZ1B IRAK2 PRKCI DGKH LRRK1 MAP2K3 MAP2K6	2.41e-05	709	80	12	GO:0016773
GeneOntologyMolecularFunction	protein kinase activity	NEK3 TRIO KALRN UHMK1 NIM1K BAZ1B IRAK2 PRKCI LRRK1 MAP2K3 MAP2K6	2.63e-05	600	80	11	GO:0004672
GeneOntologyMolecularFunction	kinase activity	NEK3 TRIO KALRN UHMK1 NIM1K BAZ1B IRAK2 PRKCI DGKH LRRK1 MAP2K3 MAP2K6	4.99e-05	764	80	12	GO:0016301
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	NEK3 TRIO KALRN UHMK1 NIM1K PRKCI LRRK1 MAP2K3 MAP2K6	7.28e-05	446	80	9	GO:0004674
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	NEK3 TRIO KALRN UHMK1 NIM1K BAZ1B IRAK2 PRKCI DGKH LRRK1 MAP2K3 MAP2K6	3.40e-04	938	80	12	GO:0016772
Domain	Ser/Thr_kinase_AS	NEK3 TRIO KALRN UHMK1 NIM1K IRAK2 PRKCI LRRK1 MAP2K3 MAP2K6	3.23e-06	357	81	10	IPR008271
Domain	PROTEIN_KINASE_ST	NEK3 TRIO KALRN UHMK1 NIM1K IRAK2 PRKCI LRRK1 MAP2K3 MAP2K6	3.66e-06	362	81	10	PS00108
Domain	Pkinase	NEK3 TRIO KALRN UHMK1 NIM1K IRAK2 PRKCI LRRK1 MAP2K3 MAP2K6	5.75e-06	381	81	10	PF00069
Domain	S_TKc	NEK3 TRIO KALRN UHMK1 NIM1K PRKCI LRRK1 MAP2K3 MAP2K6	2.50e-05	359	81	9	SM00220
Domain	PROTEIN_KINASE_ATP	NEK3 TRIO KALRN UHMK1 NIM1K IRAK2 PRKCI LRRK1 MAP2K3 MAP2K6	2.88e-05	459	81	10	PS00107
Domain	Prot_kinase_dom	NEK3 TRIO KALRN UHMK1 NIM1K IRAK2 PRKCI LRRK1 MAP2K3 MAP2K6	4.91e-05	489	81	10	IPR000719
Domain	PROTEIN_KINASE_DOM	NEK3 TRIO KALRN UHMK1 NIM1K IRAK2 PRKCI LRRK1 MAP2K3 MAP2K6	5.26e-05	493	81	10	PS50011
Domain	Kinase-like_dom	NEK3 TRIO KALRN UHMK1 NIM1K IRAK2 PRKCI LRRK1 MAP2K3 MAP2K6	1.15e-04	542	81	10	IPR011009
Domain	Spectrin	TRIO KALRN SYNE1	1.31e-04	23	81	3	PF00435
Domain	Spectrin_repeat	TRIO KALRN SYNE1	2.65e-04	29	81	3	IPR002017
Domain	Spectrin/alpha-actinin	TRIO KALRN SYNE1	3.56e-04	32	81	3	IPR018159
Domain	SPEC	TRIO KALRN SYNE1	3.56e-04	32	81	3	SM00150
Domain	ARM-type_fold	VAC14 SAAL1 NBEAL1 INSC RTTN LTN1 SYMPK	6.71e-04	339	81	7	IPR016024
Domain	PNMA	PNMA8A PNMA8B	9.96e-04	11	81	2	PF14893
Domain	PNMA	PNMA8A PNMA8B	9.96e-04	11	81	2	IPR026523
Domain	ARM-like	VAC14 SAAL1 INSC RTTN LTN1 SYMPK	1.13e-03	270	81	6	IPR011989
Domain	-	VAC14 SAAL1 INSC RTTN SYMPK	2.79e-03	222	81	5	1.25.10.10
Domain	PH	TRIO KALRN PLEKHM2 CADPS DGKH	3.19e-03	229	81	5	PF00169
Domain	CRAL_TRIO	TRIO KALRN	3.70e-03	21	81	2	PF00650
Domain	Peptidase_M14	CPXM2 AGBL5	4.43e-03	23	81	2	PF00246
Domain	-	TRIO KALRN	4.43e-03	23	81	2	3.40.525.10
Domain	Peptidase_M14	CPXM2 AGBL5	4.43e-03	23	81	2	IPR000834
Domain	SEC14	TRIO KALRN	5.22e-03	25	81	2	SM00516
Domain	Protein_kinase_ATP_BS	NEK3 KALRN NIM1K PRKCI MAP2K3 MAP2K6	6.07e-03	379	81	6	IPR017441
Domain	CRAL_TRIO	TRIO KALRN	6.08e-03	27	81	2	PS50191
Domain	CRAL-TRIO_dom	TRIO KALRN	6.53e-03	28	81	2	IPR001251
Domain	PH	TRIO KALRN PLEKHM2 CADPS DGKH	7.20e-03	278	81	5	SM00233
Domain	PH_DOMAIN	TRIO KALRN PLEKHM2 CADPS DGKH	7.31e-03	279	81	5	PS50003
Domain	PH_domain	TRIO KALRN PLEKHM2 CADPS DGKH	7.41e-03	280	81	5	IPR001849
Pathway	WP_GNAQ_PATHWAYS_IN_PORTWINE_STAIN	TRIO MAP2K3 MAP2K6	8.78e-05	21	59	3	M48342
Pathway	REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION	IRAK2 MAP2K3 MAP2K6	1.16e-04	23	59	3	M17243
Pathway	REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION	IRAK2 MAP2K3 MAP2K6	1.32e-04	24	59	3	MM15133
Pubmed	p150(Glued), Dynein, and microtubules are specifically required for activation of MKK3/6 and p38 MAPKs.	MAP2K3 MAP2K6 DNAH11	1.31e-07	5	83	3	15375157
Pubmed	Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression.	MAP2K3 MAP2K6	5.63e-06	2	83	2	10097111
Pubmed	Differential roles of MAPK kinases MKK3 and MKK6 in osteoclastogenesis and bone loss.	MAP2K3 MAP2K6	5.63e-06	2	83	2	24400116
Pubmed	MKK3, an upstream activator of p38, contributes to formalin phase 2 and late allodynia in mice.	MAP2K3 MAP2K6	5.63e-06	2	83	2	19427893
Pubmed	Specific calcineurin targeting in macrophages confers resistance to inflammation via MKP-1 and p38.	MAP2K3 MAP2K6	5.63e-06	2	83	2	24596247
Pubmed	Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis.	MAP2K3 MAP2K6	5.63e-06	2	83	2	12151339
Pubmed	Estrogen receptor β and 17β-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer.	ESR2 HSD17B6	5.63e-06	2	83	2	22114194
Pubmed	Decreased ERβ expression and high cyclin D1 expression may predict early CRC recurrence in high-risk Duke's B and Duke's C stage.	ESR2 CCND2	5.63e-06	2	83	2	34077003
Pubmed	Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP.	TRIO KALRN	5.63e-06	2	83	2	26858404
Pubmed	Role of MAPK kinase 6 in arthritis: distinct mechanism of action in inflammation and cytokine expression.	MAP2K3 MAP2K6	5.63e-06	2	83	2	19561096
Pubmed	Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade.	MAP2K3 MAP2K6	1.69e-05	3	83	2	8626699
Pubmed	p38α Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis.	MAP2K3 MAP2K6	1.69e-05	3	83	2	21610252
Pubmed	Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.	TRIO KALRN	1.69e-05	3	83	2	31801062
Pubmed	Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells.	MAP2K3 MAP2K6	1.69e-05	3	83	2	7750576
Pubmed	Protein kinase Cι promotes UBF1-ECT2 binding on ribosomal DNA to drive rRNA synthesis and transformed growth of non-small-cell lung cancer cells.	UBTF PRKCI	1.69e-05	3	83	2	32350115
Pubmed	MKK3 and -6-dependent activation of p38alpha MAP kinase is required for cytoskeletal changes in pulmonary microvascular endothelial cells induced by ICAM-1 ligation.	MAP2K3 MAP2K6	1.69e-05	3	83	2	15516490
Pubmed	Novel ASK1 Inhibitor AGI-1067 Attenuates AGE-Induced Fibrotic Response by Suppressing the MKKs/p38 MAPK Pathway in Human Coronary Arterial Smooth Muscle Cells.	MAP2K3 MAP2K6	1.69e-05	3	83	2	30305582
Pubmed	Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferons.	MAP2K3 MAP2K6	1.69e-05	3	83	2	15644321
Pubmed	A diacylglycerol kinase inhibitor, R59022, stimulates glucose transport through a MKK3/6-p38 signaling pathway in skeletal muscle cells.	MAP2K3 MAP2K6	1.69e-05	3	83	2	17588539
Pubmed	Differential activation of p38MAPK isoforms by MKK6 and MKK3.	MAP2K3 MAP2K6	1.69e-05	3	83	2	20004242
Pubmed	Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes.	MAP2K3 MAP2K6	1.69e-05	3	83	2	15778394
Pubmed	p38α MAPK is required for tooth morphogenesis and enamel secretion.	MAP2K3 MAP2K6	1.69e-05	3	83	2	25406311
Pubmed	p38 MAPK α and β isoforms differentially regulate plasma membrane localization of MRP2.	MAP2K3 MAP2K6	1.69e-05	3	83	2	27012769
Pubmed	Balance between MKK6 and MKK3 mediates p38 MAPK associated resistance to cisplatin in NSCLC.	MAP2K3 MAP2K6	1.69e-05	3	83	2	22164285
Pubmed	NR2F1 Is a Barrier to Dissemination of Early-Stage Breast Cancer Cells.	MAP2K3 MAP2K6	1.69e-05	3	83	2	35471456
Pubmed	Translational control of NKT cell cytokine production by p38 MAPK.	MAP2K3 MAP2K6	3.37e-05	4	83	2	21368234
Pubmed	Myeloid p38 activation maintains macrophage-liver crosstalk and BAT thermogenesis through IL-12-FGF21 axis.	MAP2K3 MAP2K6	3.37e-05	4	83	2	35592906
Pubmed	Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence.	MAP2K3 MAP2K6	3.37e-05	4	83	2	11971971
Pubmed	MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.	MAP2K3 MAP2K6	3.37e-05	4	83	2	8622669
Pubmed	The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy.	MAP2K3 MAP2K6	3.37e-05	4	83	2	11593045
Pubmed	MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2.	MAP2K3 MAP2K6	3.37e-05	4	83	2	20067578
Pubmed	Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2.	MAP2K3 MAP2K6	3.37e-05	4	83	2	9768359
Pubmed	Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain.	MAP2K3 MAP2K6	3.37e-05	4	83	2	10497253
Pubmed	Mechanism of p38 MAP kinase activation in vivo.	MAP2K3 MAP2K6	3.37e-05	4	83	2	12893778
Pubmed	Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3.	MAP2K3 MAP2K6	3.37e-05	4	83	2	12054652
Pubmed	Nuclear localization of p38 MAPK in response to DNA damage.	MAP2K3 MAP2K6	3.37e-05	4	83	2	19564926
Pubmed	Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.	GPR158 SYNE1 XDH	3.68e-05	27	83	3	18649358
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	UBR5 PLEKHM2 CADPS SYNE1 PHF8 MADD LARGE1	5.52e-05	407	83	7	12693553
Pubmed	Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo.	MAP2K3 MAP2K6	5.60e-05	5	83	2	16199873
Pubmed	Assembly of high order G alpha q-effector complexes with RGS proteins.	TRIO KALRN	5.60e-05	5	83	2	18936096
Pubmed	MEK2 controls the activation of MKK3/MKK6-p38 axis involved in the MDA-MB-231 breast cancer cell survival: Correlation with cyclin D1 expression.	MAP2K3 MAP2K6	5.60e-05	5	83	2	27181679
Pubmed	Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib.	MAP2K3 MAP2K6	5.60e-05	5	83	2	19672773
Pubmed	Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation.	MAP2K3 MAP2K6	5.60e-05	5	83	2	16728640
Pubmed	H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells.	MAP2K3 MAP2K6	5.60e-05	5	83	2	15677464
Pubmed	The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro.	MAP2K3 MAP2K6	5.60e-05	5	83	2	19302196
Pubmed	MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation.	MAP2K3 MAP2K6	5.60e-05	5	83	2	35971771
Pubmed	Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.	BAZ1B MADD DNAH11	7.43e-05	34	83	3	19060911
Pubmed	LDLs stimulate p38 MAPKs and wound healing through SR-BI independently of Ras and PI3 kinase.	MAP2K3 MAP2K6	8.39e-05	6	83	2	18757346
Pubmed	Stress-activated kinase pathway alteration is a frequent event in bladder cancer.	MAP2K3 MAP2K6	8.39e-05	6	83	2	22154358
Pubmed	Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation.	MAP2K3 MAP2K6	8.39e-05	6	83	2	11062068
Pubmed	Mouse preimplantation embryo responses to culture medium osmolarity include increased expression of CCM2 and p38 MAPK activation.	MAP2K3 MAP2K6	8.39e-05	6	83	2	17214902
Pubmed	Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3.	MAP2K3 MAP2K6	8.39e-05	6	83	2	12589052
Pubmed	PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation.	UBTF PHF8	8.39e-05	6	83	2	20208542
Pubmed	WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci.	SMARCA1 BAZ1B	8.39e-05	6	83	2	11980720
Pubmed	Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades.	MAP2K3 MAP2K6	8.39e-05	6	83	2	9841871
Pubmed	DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.	WDR19 WDR91 SMARCA1 PHF8	9.55e-05	99	83	4	34161765
Pubmed	Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.	MAP2K3 MAP2K6	1.17e-04	7	83	2	11062067
Pubmed	DJ-1 modulates the p38 mitogen-activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1.	MAP2K3 MAP2K6	1.17e-04	7	83	2	20213747
Pubmed	Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis.	MAP2K3 MAP2K6	1.17e-04	7	83	2	23202732
Pubmed	Role of Src signal transduction pathways in scatter factor-mediated cellular protection.	MAP2K3 MAP2K6	1.17e-04	7	83	2	19047046
Pubmed	Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN.	MAP2K3 MAP2K6	1.56e-04	8	83	2	12761180
Pubmed	Genetic Analyses Reveal Functions for MAP2K3 and MAP2K6 in Mouse Testis Determination.	MAP2K3 MAP2K6	1.56e-04	8	83	2	27009039
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	VTN CADPS RTTN PHF8 GOLGA3 MGAM2 LARGE1	1.88e-04	496	83	7	31343991
Pubmed	Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2.	MAP2K3 MAP2K6	2.00e-04	9	83	2	11279118
Pubmed	Mxi2 promotes stimulus-independent ERK nuclear translocation.	MAP2K3 MAP2K6	2.00e-04	9	83	2	17255949
Pubmed	Interaction with podocin facilitates nephrin signaling.	MAP2K3 MAP2K6	2.00e-04	9	83	2	11562357
Pubmed	Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases.	MAP2K3 MAP2K6	2.00e-04	9	83	2	15866172
Pubmed	Tat engagement of p38 MAP kinase and IRF7 pathways leads to activation of interferon-stimulated genes in antigen-presenting cells.	MAP2K3 MAP2K6	2.00e-04	9	83	2	23535064
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	UBR5 GPR158 CADPS SYNE1 PHF8	2.09e-04	225	83	5	12168954
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	WDR19 ZSWIM8 TRIO KALRN COG1 CADPS SYNE1 PRMT2 PRDM4 GOLGA3 MADD	2.37e-04	1285	83	11	35914814
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	KALRN PLEKHM2 SYNE1 PRDM4 DNAH11	2.45e-04	233	83	5	37704626
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	VTN PCNX4 UBTF SMARCA1 BAZ1B PHF8 ANAPC5	2.90e-04	533	83	7	30554943
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	VAC14 TRIO KALRN PLEKHM2 PROM2 PCNX4 RTTN LRRK1 MADD SYMPK	3.00e-04	1105	83	10	35748872
Pubmed	Dynamics of ovarian development in the FORKO immature mouse: structural and functional implications for ovarian reserve.	ESR2 CCND2	3.66e-04	12	83	2	12801993
Pubmed	Screening of hepatocyte proteins binding to F protein of hepatitis C virus by yeast two-hybrid system.	VTN PCNX4	3.66e-04	12	83	2	16237761
Pubmed	Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients.	MAP2K3 MAP2K6	3.66e-04	12	83	2	20805296
Pubmed	High-throughput mapping of a dynamic signaling network in mammalian cells.	UBTF UHMK1 IRAK2 MAP2K3 ANAPC5	4.06e-04	260	83	5	15761153
Pubmed	The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20.	PHF8 ANAPC5	4.31e-04	13	83	2	23979597
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	TRIO KALRN PCNX4 SYNE1	4.81e-04	151	83	4	17043677
Pubmed	Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.	ESR2 PRMT2	5.03e-04	14	83	2	12039952
Pubmed	Rotatin is a novel gene required for axial rotation and left-right specification in mouse embryos.	RTTN DNAH11	6.61e-04	16	83	2	11900971
Pubmed	Congenital Muscular Dystrophy Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	SYNE1 LARGE1	7.48e-04	17	83	2	20301468
Pubmed	Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.	UBR5 ANAPC5	7.48e-04	17	83	2	29033132
Pubmed	Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.	RGS20 RGS22	7.48e-04	17	83	2	20627871
Pubmed	MD-2: the Toll 'gatekeeper' in endotoxin signalling.	IRAK2 MAP2K3 MAP2K6	7.52e-04	74	83	3	15276183
Pubmed	Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.	GPR158 CADPS PNMA8B	8.13e-04	76	83	3	10574461
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	ZSWIM8 UBR5 DGKH CHCHD1 GOLGA3 SYMPK CCND2	8.50e-04	639	83	7	23443559
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	SAAL1 TRIO UBTF LTN1 PRKCI PSMD13 PHF8 MADD SYMPK	8.91e-04	1049	83	9	27880917
Pubmed	The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies.	MAP2K3 MAP2K6 CCND2	9.43e-04	80	83	3	28205554
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	ZSWIM8 TRIO KALRN GPR158 CADPS MADD	9.78e-04	475	83	6	31040226
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	VAC14 SAAL1 COG1 LTN1	9.86e-04	183	83	4	23956138
Pubmed	Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1.	BAZ1B ANAPC5	1.04e-03	20	83	2	18162579
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	SAAL1 UBTF RXFP2 LTN1 BAZ1B MADD TGS1 CCND2 NCKAP1L	1.12e-03	1084	83	9	11544199
Pubmed	CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis.	SMARCA1 BAZ1B	1.15e-03	21	83	2	22154806
Pubmed	Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins.	UHMK1 PRMT2	1.26e-03	22	83	2	26420826
Pubmed	Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways.	MAP2K3 MAP2K6	1.26e-03	22	83	2	15767678
Pubmed	Par3 is essential for the establishment of planar cell polarity of inner ear hair cells.	TRIO PRKCI	1.50e-03	24	83	2	30814219
Pubmed	Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.	AGBL5 TTLL13	1.63e-03	25	83	2	29593216
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	WDR91 ZSWIM8 VAC14 PROM2 PRDM4 MAP2K3 ANAPC5 MADD	1.65e-03	925	83	8	28986522
Pubmed	Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZSWIM8 UBR5 PLEKHM2	1.79e-03	100	83	3	10048485
Cytoband	6q25	SYNE1 ULBP3	2.11e-04	12	83	2	6q25
GeneFamily	Mitogen-activated protein kinase kinases	MAP2K3 MAP2K6	1.82e-04	7	54	2	653
GeneFamily	Paraneoplastic Ma antigens	PNMA8A PNMA8B	4.73e-04	11	54	2	671
GeneFamily	Zinc fingers C2H2-type\|PR/SET domain family	PRDM10 PRDM4	1.16e-03	17	54	2	1197
GeneFamily	Regulators of G-protein signaling	RGS20 RGS22	1.77e-03	21	54	2	720
Disease	restrictive cardiomyopathy (is_implicated_in)	MAP2K3 MAP2K6	1.11e-04	6	81	2	DOID:397 (is_implicated_in)
Disease	sialic acid-binding Ig-like lectin 12 measurement	VTN KALRN	2.06e-04	8	81	2	EFO_0802066
Disease	vesicular integral-membrane protein VIP36 measurement	VTN KALRN	3.30e-04	10	81	2	EFO_0022012
Disease	apolipoprotein B measurement	VTN ABCB11 PCSK7 BAZ1B MAP2K6 SYMPK DNAH11 CCND2	4.74e-04	663	81	8	EFO_0004615
Disease	free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	ABCB11 PCSK7 BAZ1B MADD DNAH11	1.50e-03	303	81	5	EFO_0004612, EFO_0020945
Disease	progression free survival, ovarian serous carcinoma	RGS20 PTCHD4	1.66e-03	22	81	2	EFO_0004920, EFO_1001516
Disease	Coronary heart disease	ESR2 DNAH11	1.98e-03	24	81	2	C0010068
Disease	HbA1c measurement	RXFP2 ABCB11 BAZ1B PSMD13 TTC6 MADD CCND2	2.56e-03	675	81	7	EFO_0004541

Protein segments in the cluster

Peptide	Gene	Start	Entry
AMAIAALDMAECNPW	AGBL5	561	Q8NDL9
LIMWLCNREREIFMS	ERC2-IT1	116	O76042
EWMGTCLLFEFMIES	PRMT2	211	P55345
MVTCMDEAVRNITWA	ARSI	266	Q5FYB1
MLDACIKWDMSAENA	BAZ1B	1171	Q9UIG0
RRMQVWDACSEALIM	COQ6	116	Q9Y2Z9
AELDFWMMRRENLSC	DNAH11	276	Q96DT5
WMMRRENLSCIYDQL	DNAH11	281	Q96DT5
RIMRMEIGWFDCNSV	ABCB11	181	O95342
QSWFDNGSICMRMEI	CPXM2	276	Q8N436
MASRERLFELWMLYC	NBEAL1	1	Q6ZS30
FIMCSMLAWLETTSE	LTN1	1246	O94822
LWMLCDQKIQFDRAM	ANAPC5	506	Q9UJX4
RRMVATWMLEVCEEQ	CCND2	56	P30279
AMNLLEDWCRGMEVD	PNMA8A	6	Q86V59
MNVICTWLTDRMDLQ	CADPS	1266	Q9ULU8
ACTELEMNVMDWLAK	HDC	111	P19113
MRGLMLVWEEFFDEL	MSANTD1	51	Q6ZTZ1
SMDRLQMLEAICKHW	LARGE1	481	O95461
DMCSFDNEQLFTMKW	PRKCI	56	P41743
MQFWEDAFLDAVMLE	MADD	1321	Q8WXG6
MHGNRATEEEMWECL	MAGEB17	211	A8MXT2
DQVRLLESCWMEVLM	ESR2	326	Q92731
DAEYEMCVRWMQLGA	MGAM2	1516	Q2M2H8
LCRNMDALSEWDWME	IRAK2	16	O43187
QFRRLQALMMECWDT	LRRK1	1491	Q38SD2
NMCLIDRWDYMTAVA	GPR158	571	Q5T848
SCLEMVRELWMWNVE	FAM182A	56	Q5T1J6
ANLEKCMSELWRMER	BAIAP2L2	131	Q6UXY1
QDRLMWIMILECGYT	PCNX4	661	Q63HM2
LEVLWNVSRMDLEMS	PCSK7	506	Q16549
WMEDLQKEMLEDVCA	KALRN	656	O60229
DLQNLMSWRFIMDLV	MME	366	P08473
MACEYLSVEVMERWI	NCKAP1L	246	P55160
LWFELSDETLCNWMM	PRDM10	271	Q9NQV6
SDETLCNWMMFVRPA	PRDM10	276	Q9NQV6
DRLEFWCTDVKSMEM	PSMD13	351	Q9UNM6
LMLCAENRKEMEDWI	DGKH	136	Q86XP1
TERYGIDCIMNDEWM	NIM1K	311	Q8IY84
SCWDLERAMTDLQNM	GOLGA3	476	Q08378
EDMILNWFTQMCLGV	NEK3	101	P51956
VMMACWKQNEFRDDA	CHCHD1	51	Q96BP2
DCAWEVVRMEIMKSL	IFNW1	161	P05000
LCEWLNTEDSMNMLK	HSD17B6	121	O14756
LLFWEDMMQQLFLDR	COG1	411	Q8WTW3
DMAWRLADGVMQCSF	FRRS1	291	Q6ZNA5
MITSLLAMDAWCFLA	C1orf112	451	Q9NSG2
QRWMEDLKLMTECEC	INSC	76	Q1MX18
FVSMNLDLLAMLVWC	FDXACB1	486	Q9BRP7
NEICRVWDMSMDEDV	SAAL1	71	Q96ER3
IITTDENECNWMMFV	PRDM4	476	Q9UKN5
ESEAEMAEWMQHLCQ	PLEKHM2	856	Q8IWE5
FREGDVWICMELMDT	MAP2K3	131	P46734
REGDVWICMELMDTS	MAP2K6	121	P52564
LLFDEVSRMDMWSVN	RTTN	951	Q86VV8
DDLIQLTAMCWMREF	VAC14	271	Q08AM6
LTAMCWMREFIQLAG	VAC14	276	Q08AM6
QDMLRSIEADSFWCM	TBC1D22B	341	Q9NU19
MTRLLDILEDYCMWR	SMARCA1	511	P28370
CELMHTEMQALRADW	SYNE1	2916	Q8NF91
SMDLMCWTDIEQFRR	RGS22	876	Q8NE09
RTEFSEENMLFWMAC	RGS20	281	O76081
MAMSLLQDWCRSLDV	PNMA8B	1	Q9ULN7
GLMTLWNVDMDCISI	PTCHD4	701	Q6ZW05
ALLWMESVQCRLMGF	RXFP2	486	Q8WXD0
NLMLKRFSDAWEMCR	WDR19	656	Q8NEZ3
VSMRDCKSWLRDFLM	ULBP3	186	Q9BZM4
VLDGISWNRAEMTMC	TTC6	46	Q86TZ1
SRVILCDMMADPWNA	PROM2	766	Q8N271
MEFETMKLEDFWCAQ	ZBED8	506	Q8IZ13
LMEWTSLQNMRETCV	SERPINB4	266	P48594
MLIAECWMSEVAVTC	XDH	921	P47989
MCRIIVHFMWEDVQQ	UQCC1	171	Q9NVA1
SELQEACWDMVSAMA	SYMPK	151	Q92797
ACWDMVSAMAGDIIL	SYMPK	156	Q92797
CASMCDEMVTLWRLA	ZSWIM8	416	A7E2V4
DVMWETIRNLDCIGM	ZNF442	56	Q9H7R0
DISWEELHCGLMMER	ZFP69B	161	Q9UJL9
DVTRFMIECDMCQDW	PHF8	51	Q9UPP1
MCCEKWSRVAEMFLF	TGS1	1	Q96RS0
RWSQEDMLTLLECMK	UBTF	21	P17480
IRLFDMQQHECAMSW	WDR91	586	A4D1P6
AMMQRDSWEDIFELL	VTN	306	P04004
SMWMIQHCARDVLEA	UHMK1	131	Q8TAS1
LRECMDTYLWEMTSG	TRIO	1311	O75962
LMESVWNMNDSCRFQ	UBR5	561	O95071
YWTDCAVSLERVMDM	TTLL13	121	A6NNM8
LVSWIVMEQSCELRM	GLYATL2	211	Q8WU03
MERYDSICNVWESMA	KLHL38	401	Q2WGJ6