Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aryl sulfotransferase activity	SULT1C2 SULT1C3	1.18e-04	10	33	2	GO:0004062
GeneOntologyMolecularFunction	superoxide-generating NADPH oxidase activator activity	SH3PXD2B SH3PXD2A	1.18e-04	10	33	2	GO:0016176
GeneOntologyMolecularFunction	magnesium ion transmembrane transporter activity	NIPAL1 NIPA2	3.99e-04	18	33	2	GO:0015095
GeneOntologyMolecularFunction	receptor tyrosine kinase binding	NCK1 PLCG1 NCK2	4.38e-04	90	33	3	GO:0030971
GeneOntologyMolecularFunction	phosphatidylinositol-5-phosphate binding	SH3PXD2B SH3PXD2A	6.56e-04	23	33	2	GO:0010314
GeneOntologyMolecularFunction	cytoskeletal anchor activity	NCK1 NCK2	7.15e-04	24	33	2	GO:0008093
GeneOntologyMolecularFunction	phosphatidylinositol-4-phosphate binding	SH3PXD2B SH3PXD2A	1.61e-03	36	33	2	GO:0070273
GeneOntologyMolecularFunction	protein tyrosine kinase binding	NCK1 PLCG1 NCK2	1.89e-03	149	33	3	GO:1990782
GeneOntologyMolecularFunction	phosphatidylinositol-3-phosphate binding	SH3PXD2B SH3PXD2A	2.85e-03	48	33	2	GO:0032266
GeneOntologyMolecularFunction	signaling receptor complex adaptor activity	NCK1 NCK2	3.59e-03	54	33	2	GO:0030159
GeneOntologyMolecularFunction	sulfotransferase activity	SULT1C2 SULT1C3	3.72e-03	55	33	2	GO:0008146
GeneOntologyBiologicalProcess	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	NCK1 NCK2	1.49e-05	4	33	2	GO:1903912
GeneOntologyBiologicalProcess	positive regulation of translation in response to endoplasmic reticulum stress	NCK1 NCK2	2.47e-05	5	33	2	GO:0036493
GeneOntologyBiologicalProcess	negative regulation of PERK-mediated unfolded protein response	NCK1 NCK2	6.91e-05	8	33	2	GO:1903898
GeneOntologyBiologicalProcess	eiF2alpha phosphorylation in response to endoplasmic reticulum stress	NCK1 NCK2	6.91e-05	8	33	2	GO:0036492
GeneOntologyBiologicalProcess	regulation of translation initiation in response to endoplasmic reticulum stress	NCK1 NCK2	6.91e-05	8	33	2	GO:0036491
GeneOntologyBiologicalProcess	positive regulation of translation in response to stress	NCK1 NCK2	6.91e-05	8	33	2	GO:0032056
GeneOntologyBiologicalProcess	signal complex assembly	NCK1 NCK2	6.91e-05	8	33	2	GO:0007172
GeneOntologyBiologicalProcess	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	NCK1 NCK2	1.62e-04	12	33	2	GO:1902237
GeneOntologyBiologicalProcess	regulation of PERK-mediated unfolded protein response	NCK1 NCK2	1.91e-04	13	33	2	GO:1903897
GeneOntologyBiologicalProcess	regulation of translation in response to endoplasmic reticulum stress	NCK1 NCK2	1.91e-04	13	33	2	GO:0036490
GeneOntologyBiologicalProcess	peptidyl-serine dephosphorylation	NCK1 NCK2	2.57e-04	15	33	2	GO:0070262
GeneOntologyBiologicalProcess	regulation of translational initiation by eIF2 alpha phosphorylation	NCK1 NCK2	2.57e-04	15	33	2	GO:0010998
GeneOntologyBiologicalProcess	regulation of translational initiation in response to stress	NCK1 NCK2	3.74e-04	18	33	2	GO:0043558
GeneOntologyBiologicalProcess	magnesium ion transmembrane transport	NIPAL1 NIPA2	3.74e-04	18	33	2	GO:1903830
GeneOntologyBiologicalProcess	negative regulation of endoplasmic reticulum unfolded protein response	NCK1 NCK2	4.17e-04	19	33	2	GO:1900102
GeneOntologyBiologicalProcess	magnesium ion transport	NIPAL1 NIPA2	4.17e-04	19	33	2	GO:0015693
GeneOntologyBiologicalProcess	PERK-mediated unfolded protein response	NCK1 NCK2	5.11e-04	21	33	2	GO:0036499
GeneOntologyBiologicalProcess	multicellular organism growth	SH3PXD2B COMT PPP1R13L CNTNAP2	6.44e-04	249	33	4	GO:0035264
GeneOntologyBiologicalProcess	negative regulation of nervous system process	CTSC CNTNAP2	6.70e-04	24	33	2	GO:0031645
GeneOntologyBiologicalProcess	spermatid development	PSME4 FAM209A CATSPER4 FAM209B	7.79e-04	262	33	4	GO:0007286
GeneOntologyBiologicalProcess	sulfation	SULT1C2 SULT1C3	8.50e-04	27	33	2	GO:0051923
GeneOntologyBiologicalProcess	spermatid differentiation	PSME4 FAM209A CATSPER4 FAM209B	8.96e-04	272	33	4	GO:0048515
GeneOntologyBiologicalProcess	regulation of translation in response to stress	NCK1 NCK2	9.14e-04	28	33	2	GO:0043555
GeneOntologyBiologicalProcess	embryonic brain development	RNF112 CNTNAP2	9.81e-04	29	33	2	GO:1990403
Domain	SH3_1	NCK1 SH3PXD2B PLCG1 PPP1R13L SH3PXD2A NCK2 ITSN2	9.91e-09	164	32	7	PF00018
Domain	SH3	NCK1 SH3PXD2B PLCG1 PPP1R13L SH3PXD2A NCK2 ITSN2	6.61e-08	216	32	7	PS50002
Domain	SH3	NCK1 SH3PXD2B PLCG1 PPP1R13L SH3PXD2A NCK2 ITSN2	6.61e-08	216	32	7	SM00326
Domain	SH3_domain	NCK1 SH3PXD2B PLCG1 PPP1R13L SH3PXD2A NCK2 ITSN2	7.49e-08	220	32	7	IPR001452
Domain	FAM209	FAM209A FAM209B	2.84e-06	2	32	2	PF15206
Domain	FAM209	FAM209A FAM209B	2.84e-06	2	32	2	IPR027943
Domain	NCK	NCK1 NCK2	2.84e-06	2	32	2	IPR017304
Domain	SH3_9	NCK1 PPP1R13L NCK2 ITSN2	9.26e-06	78	32	4	PF14604
Domain	Mg_trans_NIPA	NIPAL1 NIPA2	4.25e-05	6	32	2	IPR008521
Domain	Mg_trans_NIPA	NIPAL1 NIPA2	4.25e-05	6	32	2	PF05653
Domain	SH2	NCK1 PLCG1 NCK2	6.79e-04	101	32	3	PF00017
Domain	SH2	NCK1 PLCG1 NCK2	8.71e-04	110	32	3	SM00252
Domain	SH2	NCK1 PLCG1 NCK2	8.94e-04	111	32	3	PS50001
Domain	SH2	NCK1 PLCG1 NCK2	9.17e-04	112	32	3	IPR000980
Domain	-	NCK1 PLCG1 NCK2	9.17e-04	112	32	3	3.30.505.10
Domain	Sulfotransferase_dom	SULT1C2 SULT1C3	1.73e-03	36	32	2	IPR000863
Domain	Sulfotransfer_1	SULT1C2 SULT1C3	1.73e-03	36	32	2	PF00685
Domain	PX	SH3PXD2B SH3PXD2A	2.57e-03	44	32	2	SM00312
Domain	PX	SH3PXD2B SH3PXD2A	3.18e-03	49	32	2	PF00787
Domain	PX	SH3PXD2B SH3PXD2A	3.31e-03	50	32	2	PS50195
Domain	-	SH3PXD2B SH3PXD2A	3.44e-03	51	32	2	3.30.1520.10
Domain	Phox	SH3PXD2B SH3PXD2A	3.57e-03	52	32	2	IPR001683
Domain	Glycoside_hydrolase_SF	SI GLB1L3	3.71e-03	53	32	2	IPR017853
Domain	TSP_1	ISM2 ADGRB1	5.20e-03	63	32	2	PF00090
Domain	TSP1	ISM2 ADGRB1	5.53e-03	65	32	2	SM00209
Domain	TSP1_rpt	ISM2 ADGRB1	5.53e-03	65	32	2	IPR000884
Domain	TSP1	ISM2 ADGRB1	5.53e-03	65	32	2	PS50092
Domain	-	GLB1L3 CNTNAP2	6.93e-03	73	32	2	2.60.120.260
Domain	SH3_2	SH3PXD2B ITSN2	9.50e-03	86	32	2	IPR011511
Domain	SH3_2	SH3PXD2B ITSN2	9.50e-03	86	32	2	PF07653
Domain	Galactose-bd-like	GLB1L3 CNTNAP2	1.13e-02	94	32	2	IPR008979
Domain	-	NBEA CNTNAP2	1.15e-02	95	32	2	2.60.120.200
Pathway	REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION	NCK1 PLCG1 NCK2	1.40e-05	27	25	3	MM14712
Pathway	REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION	NCK1 PLCG1 NCK2	1.75e-05	29	25	3	M779
Pathway	PID_NEPHRIN_NEPH1_PATHWAY	NCK1 PLCG1 NCK2	2.14e-05	31	25	3	M193
Pathway	PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY	NCK1 PLCG1 NCK2	3.11e-05	35	25	3	M127
Pathway	REACTOME_RHOU_GTPASE_CYCLE	NCK1 NCK2 ITSN2	4.32e-05	39	25	3	MM15607
Pathway	REACTOME_RHOU_GTPASE_CYCLE	NCK1 NCK2 ITSN2	4.66e-05	40	25	3	M41816
Pathway	REACTOME_NEPHRIN_FAMILY_INTERACTIONS	NCK1 NCK2	1.08e-04	9	25	2	MM14966
Pathway	REACTOME_SIGNALING_BY_PDGF	NCK1 PLCG1 NCK2	1.35e-04	57	25	3	MM14713
Pathway	REACTOME_SIGNALING_BY_PDGF	NCK1 PLCG1 NCK2	1.43e-04	58	25	3	M2049
Pathway	PID_FAK_PATHWAY	NCK1 PLCG1 NCK2	1.50e-04	59	25	3	M281
Pathway	REACTOME_ACTIVATION_OF_RAC1	NCK1 NCK2	2.33e-04	13	25	2	M6322
Pathway	PID_VEGFR1_2_PATHWAY	NCK1 PLCG1 NCK2	2.39e-04	69	25	3	M237
Pathway	PID_MET_PATHWAY	NCK1 PLCG1 NCK2	3.56e-04	79	25	3	M48
Pathway	WP_SULFATION_BIOTRANSFORMATION_REACTION	SULT1C2 SULT1C3	4.04e-04	17	25	2	M39483
Pathway	KEGG_MEDICUS_PATHOGEN_ESCHERICHIA_EAE_TIR_TO_ACTIN_SIGNALING_PATHWAY	NCK1 NCK2	4.04e-04	17	25	2	M47728
Pathway	KEGG_ERBB_SIGNALING_PATHWAY	NCK1 PLCG1 NCK2	4.73e-04	87	25	3	M12467
Pathway	WP_ERBB_SIGNALING	NCK1 PLCG1 NCK2	5.58e-04	92	25	3	M39715
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_ACTIN_SIGNALING_PATHWAY	NCK1 NCK2	6.21e-04	21	25	2	M47722
Pathway	REACTOME_NEPHRIN_FAMILY_INTERACTIONS	NCK1 NCK2	7.47e-04	23	25	2	M913
Pathway	REACTOME_SIGNALING_BY_VEGF	NCK1 PLCG1 NCK2	7.75e-04	103	25	3	MM14752
Pathway	REACTOME_SIGNALING_BY_VEGF	NCK1 PLCG1 NCK2	8.43e-04	106	25	3	M27077
Pathway	REACTOME_MISCELLANEOUS_TRANSPORT_AND_BINDING_EVENTS	NIPAL1 NIPA2	8.83e-04	25	25	2	MM15172
Pathway	KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY	NCK1 PLCG1 NCK2	8.90e-04	108	25	3	M9904
Pathway	REACTOME_MISCELLANEOUS_TRANSPORT_AND_BINDING_EVENTS	NIPAL1 NIPA2	9.56e-04	26	25	2	M27424
Pathway	PID_VEGFR1_PATHWAY	NCK1 PLCG1	9.56e-04	26	25	2	M226
Pathway	REACTOME_TCR_SIGNALING	NCK1 PLCG1 PSME4	9.63e-04	111	25	3	MM14803
Pathway	REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES	NCK1 PLCG1	1.03e-03	27	25	2	MM14809
Pathway	PID_CDC42_REG_PATHWAY	PLCG1 ITSN2	1.27e-03	30	25	2	M83
Pathway	REACTOME_TCR_SIGNALING	NCK1 PLCG1 PSME4	1.33e-03	124	25	3	M15381
Pathway	PID_NETRIN_PATHWAY	NCK1 PLCG1	1.45e-03	32	25	2	M108
Pathway	PID_PDGFRB_PATHWAY	NCK1 PLCG1 NCK2	1.49e-03	129	25	3	M186
Pathway	REACTOME_DISEASES_OF_CARBOHYDRATE_METABOLISM	SI GYS2	1.64e-03	34	25	2	M27546
Pathway	REACTOME_RHOV_GTPASE_CYCLE	NCK1 NCK2	1.94e-03	37	25	2	M41819
Pathway	REACTOME_RHOV_GTPASE_CYCLE	NCK1 NCK2	1.94e-03	37	25	2	MM15610
Pathway	WP_BRAINDERIVED_NEUROTROPHIC_FACTOR_BDNF_SIGNALING	NCK1 PLCG1 NCK2	2.04e-03	144	25	3	M39691
Pathway	REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES	NCK1 PLCG1	2.15e-03	39	25	2	M16523
Pathway	REACTOME_DAG_AND_IP3_SIGNALING	NBEA PLCG1	2.37e-03	41	25	2	M512
Pathway	WP_GENES_CONTROLLING_NEPHROGENESIS	NCK1 NCK2	2.73e-03	44	25	2	M39891
Pathway	PID_INSULIN_PATHWAY	NCK1 NCK2	2.73e-03	44	25	2	M16
Pathway	REACTOME_NETRIN_1_SIGNALING	NCK1 PLCG1	2.73e-03	44	25	2	M875
Pathway	WP_EGFEGFR_SIGNALING	NCK1 PLCG1 NCK2	2.85e-03	162	25	3	M39334
Pathway	WP_ERBB_SIGNALING_PATHWAY	NCK1 PLCG1	2.98e-03	46	25	2	MM15950
Pubmed	Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.	NCK1 SH3PXD2B SH3PXD2A NCK2 ITSN2	1.15e-09	50	33	5	19807924
Pubmed	High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains.	NCK1 PLCG1 NCK2	1.55e-08	6	33	3	1409582
Pubmed	Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor.	NCK1 PLCG1 NCK2	2.72e-08	7	33	3	12074588
Pubmed	Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome.	NCK1 SH3PXD2A NCK2 ITSN2	2.38e-07	56	33	4	22745667
Pubmed	The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma.	SH3PXD2B SH3PXD2A	8.73e-07	2	33	2	27802184
Pubmed	Fine tuning of the threshold of T cell selection by the Nck adapters.	NCK1 NCK2	8.73e-07	2	33	2	21078909
Pubmed	Non-compensating roles between Nckalpha and Nckbeta in PDGF-BB signaling to promote human dermal fibroblast migration.	NCK1 NCK2	8.73e-07	2	33	2	19242519
Pubmed	Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire.	NCK1 NCK2	8.73e-07	2	33	2	20709959
Pubmed	Regulation of human cytosolic sulfotransferases 1C2 and 1C3 by nuclear signaling pathways in LS180 colorectal adenocarcinoma cells.	SULT1C2 SULT1C3	8.73e-07	2	33	2	24335393
Pubmed	Endothelial NCK2 promotes atherosclerosis progression in male but not female Nck1-null atheroprone mice.	NCK1 NCK2	8.73e-07	2	33	2	36035930
Pubmed	[A uNick protein].	NCK1 NCK2	8.73e-07	2	33	2	21880263
Pubmed	Nck adaptor proteins modulate differentiation and effector function of T cells.	NCK1 NCK2	8.73e-07	2	33	2	25995205
Pubmed	Nck adaptor proteins control the organization of neuronal circuits important for walking.	NCK1 NCK2	8.73e-07	2	33	2	18093944
Pubmed	Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation.	NCK1 NCK2	8.73e-07	2	33	2	19596797
Pubmed	Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development.	NCK1 NCK2	8.73e-07	2	33	2	37479911
Pubmed	Nck influences preosteoblastic/osteoblastic migration and bone mass.	NCK1 NCK2	8.73e-07	2	33	2	26621720
Pubmed	The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains.	NCK1 NCK2	8.73e-07	2	33	2	16636066
Pubmed	Nck-1 antagonizes the endoplasmic reticulum stress-induced inhibition of translation.	NCK1 NCK2	2.62e-06	3	33	2	14676213
Pubmed	Selective role of Nck1 in atherogenic inflammation and plaque formation.	NCK1 NCK2	2.62e-06	3	33	2	32427580
Pubmed	Nck proteins maintain the adult glomerular filtration barrier.	NCK1 NCK2	2.62e-06	3	33	2	19443634
Pubmed	Identification and kinetic analysis of the interaction between Nck-2 and DOCK180.	NCK1 NCK2	2.62e-06	3	33	2	11240126
Pubmed	Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling.	NCK1 NCK2	2.62e-06	3	33	2	33917227
Pubmed	Nck beta interacts with tyrosine-phosphorylated disabled 1 and redistributes in Reelin-stimulated neurons.	NCK1 NCK2	2.62e-06	3	33	2	14517291
Pubmed	Genetic disruption of the sh3pxd2a gene reveals an essential role in mouse development and the existence of a novel isoform of tks5.	SH3PXD2B SH3PXD2A	2.62e-06	3	33	2	25259869
Pubmed	Nck adaptors, besides promoting N-WASP mediated actin-nucleation activity at pedestals, influence the cellular levels of enteropathogenic Escherichia coli Tir effector.	NCK1 NCK2	2.62e-06	3	33	2	25482634
Pubmed	Nck-2 interacts with focal adhesion kinase and modulates cell motility.	NCK1 NCK2	2.62e-06	3	33	2	11950595
Pubmed	Nck adapter proteins promote podosome biogenesis facilitating extracellular matrix degradation and cancer invasion.	NCK1 NCK2	2.62e-06	3	33	2	31638742
Pubmed	Src homology domain 2 adaptors affect adherence of Salmonella enterica serovar Typhimurium to non-phagocytic cells.	NCK1 NCK2	2.62e-06	3	33	2	17906149
Pubmed	A Study of Interleukin-2 Production and Nck Adaptor Molecule Gene Expression in Systemic Lupus Erythematosus Patients.	NCK1 NCK2	2.62e-06	3	33	2	29911835
Pubmed	Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation.	SH3PXD2B SH3PXD2A	2.62e-06	3	33	2	20609497
Pubmed	A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily.	SULT1C2 SULT1C3	2.62e-06	3	33	2	15167709
Pubmed	Functional characterization of NIPA2, a selective Mg2+ transporter.	NIPAL1 NIPA2	2.62e-06	3	33	2	18667602
Pubmed	The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements.	NCK1 NCK2	2.62e-06	3	33	2	19371741
Pubmed	Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma-associated proteins. Characterization of a c-Src-dependent 97-kD protein in vascular smooth muscle cells.	NCK1 PLCG1	2.62e-06	3	33	2	9314836
Pubmed	Nephrin Suppresses Hippo Signaling through the Adaptor Proteins Nck and WTIP.	NCK1 NCK2	2.62e-06	3	33	2	27033705
Pubmed	Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B.	NCK1 NCK2	2.62e-06	3	33	2	16769879
Pubmed	The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors.	NCK1 NCK2	5.23e-06	4	33	2	1333047
Pubmed	Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon.	NCK1 NCK2	5.23e-06	4	33	2	17617578
Pubmed	Expression of the sulfotransferase 1C family: implications for xenobiotic toxicity.	SULT1C2 SULT1C3	5.23e-06	4	33	2	24028175
Pubmed	Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor.	NCK1 NCK2	5.23e-06	4	33	2	18765673
Pubmed	Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes.	NCK1 NCK2	5.23e-06	4	33	2	16525419
Pubmed	Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells.	NCK1 NCK2	5.23e-06	4	33	2	23913047
Pubmed	The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins.	NCK1 NCK2	5.23e-06	4	33	2	12637565
Pubmed	Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2.	NCK1 PLCG1	5.23e-06	4	33	2	9600074
Pubmed	Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation.	NCK1 NCK2	5.23e-06	4	33	2	12110186
Pubmed	NCK is critical for the development of deleted in colorectal cancer (DCC) sensitive spinal circuits.	NCK1 NCK2	5.23e-06	4	33	2	25913325
Pubmed	Improved two-dimensional reversed phase-reversed phase LC-MS/MS approach for identification of peptide-protein interactions.	NCK1 NCK2	5.23e-06	4	33	2	22074159
Pubmed	Identification of Nck family genes, chromosomal localization, expression, and signaling specificity.	NCK1 NCK2	8.72e-06	5	33	2	9737977
Pubmed	Novel Src homology 3 domain-binding motifs identified from proteomic screen of a Pro-rich region.	NCK1 PLCG1	8.72e-06	5	33	2	15929943
Pubmed	Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase.	NCK1 PLCG1	8.72e-06	5	33	2	15556869
Pubmed	FAM209 associates with DPY19L2, and is required for sperm acrosome biogenesis and fertility in mice.	FAM209A FAM209B	8.72e-06	5	33	2	34471926
Pubmed	A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors.	NCK1 NCK2	8.72e-06	5	33	2	35294890
Pubmed	Nck and Cdc42 co-operate to recruit N-WASP to promote FcγR-mediated phagocytosis.	NCK1 NCK2	8.72e-06	5	33	2	22454526
Pubmed	The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network.	NCK1 NCK2	8.72e-06	5	33	2	12808099
Pubmed	Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity.	SH3PXD2B SH3PXD2A	8.72e-06	5	33	2	19755710
Pubmed	Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2.	NCK1 NCK2	8.72e-06	5	33	2	12147689
Pubmed	Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics.	NCK1 NCK2	1.31e-05	6	33	2	24287595
Pubmed	Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress.	NCK1 NCK2	1.31e-05	6	33	2	16835242
Pubmed	Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.	NCK1 NCK2	1.31e-05	6	33	2	17803907
Pubmed	Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1.	NCK1 NCK2	1.31e-05	6	33	2	12091389
Pubmed	Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene.	NCK1 PLCG1	1.31e-05	6	33	2	7517397
Pubmed	Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice.	FAM209A FAM209B	1.31e-05	6	33	2	38573307
Pubmed	Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways.	NCK1 PLCG1	1.31e-05	6	33	2	8890167
Pubmed	Requisite role for Nck adaptors in cardiovascular development, endothelial-to-mesenchymal transition, and directed cell migration.	NCK1 NCK2	1.31e-05	6	33	2	25691664
Pubmed	BLNK: a central linker protein in B cell activation.	NCK1 PLCG1	1.31e-05	6	33	2	9697839
Pubmed	Association of signaling proteins with a nonmitogenic heterodimeric complex composed of epidermal growth factor receptor and kinase-inactive p185c-neu.	NCK1 PLCG1	1.83e-05	7	33	2	8561895
Pubmed	Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling.	NCK1 PLCG1	1.83e-05	7	33	2	8910519
Pubmed	Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1.	NCK1 PLCG1	1.83e-05	7	33	2	10391903
Pubmed	Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.	NCK1 PLCG1	1.83e-05	7	33	2	21725281
Pubmed	Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization.	NCK1 NCK2	2.44e-05	8	33	2	26659946
Pubmed	A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs.	NCK1 PLCG1	2.44e-05	8	33	2	9344857
Pubmed	Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma.	NCK1 SH3PXD2A	2.44e-05	8	33	2	18296648
Pubmed	Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.	NCK1 NCK2	2.44e-05	8	33	2	10026169
Pubmed	Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse.	NCK1 PLCG1	3.13e-05	9	33	2	15696170
Pubmed	The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals.	NCK1 NCK2	3.13e-05	9	33	2	11557983
Pubmed	Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins.	NCK1 NCK2	3.13e-05	9	33	2	15110774
Pubmed	Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck.	NCK1 NCK2	3.13e-05	9	33	2	10428862
Pubmed	Stromal-cell-derived factor-1/CXCL12-induced chemotaxis of a T cell line involves intracellular signaling through Cbl and Cbl-b and their regulation by Src kinases and CD45.	NCK1 PLCG1	3.91e-05	10	33	2	16503409
Pubmed	Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.	NCK1 PLCG1 NCK2	4.63e-05	73	33	3	24728074
Pubmed	90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling.	PLCG1 NCK2	4.78e-05	11	33	2	15117958
Pubmed	Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation.	NCK1 PLCG1	4.78e-05	11	33	2	11470823
Pubmed	Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.	NCK1 PLCG1 ITSN2	5.02e-05	75	33	3	15951569
Pubmed	Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors.	NCK1 PLCG1 NCK2	5.43e-05	77	33	3	22973453
Pubmed	The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.	NCK1 NCK2 ITSN2	6.31e-05	81	33	3	20697350
Pubmed	Structural and chemical profiling of the human cytosolic sulfotransferases.	SULT1C2 SULT1C3	6.77e-05	13	33	2	17425406
Pubmed	A quantitative protein interaction network for the ErbB receptors using protein microarrays.	NCK1 PLCG1 NCK2	8.64e-05	90	33	3	16273093
Pubmed	Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.	NCK1 PLCG1	1.04e-04	16	33	2	10022833
Pubmed	Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.	SH3PXD2B PLCG1 SH3PXD2A	1.29e-04	103	33	3	21706016
Pubmed	Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics.	NCK1 PLCG1	1.64e-04	20	33	2	31591574
Pubmed	Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome.	NCK1 SH3PXD2A	2.58e-04	25	33	2	16374509
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	NCK1 PLCG1 ITSN2	2.74e-04	133	33	3	15144186
Pubmed	The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.	NCK1 NCK2 ITSN2	2.80e-04	134	33	3	24658140
Pubmed	In silico prediction of physical protein interactions and characterization of interactome orphans.	NCK1 NCK2 ITSN2	2.93e-04	136	33	3	25402006
Pubmed	Genetic associations of brain structural networks in schizophrenia: a preliminary study.	COMT GYS2	3.99e-04	31	33	2	20691427
Pubmed	SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome.	NCK1 PLCG1	4.25e-04	32	33	2	22974441
Pubmed	A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.	COMT PPP1R13L	5.69e-04	37	33	2	19116388
Pubmed	A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.	FAM209A FAM209B	7.69e-04	43	33	2	25130324
Pubmed	The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.	NCK1 PLCG1	8.80e-04	46	33	2	23793062
Pubmed	The sperm-associated antigen 6 interactome and its role in spermatogenesis.	PSME4 FAM209A FAM209B	8.87e-04	199	33	3	31146259
Interaction	FASLG interactions	NCK1 SH3PXD2B SH3PXD2A NCK2 ITSN2	5.32e-07	105	31	5	int:FASLG
Interaction	WIPF3 interactions	NCK1 NCK2 ITSN2	1.82e-06	16	31	3	int:WIPF3
Interaction	SH3PXD2B interactions	NCK1 SH3PXD2B SH3PXD2A NCK2	3.48e-06	68	31	4	int:SH3PXD2B
Interaction	PIK3AP1 interactions	NCK1 NCK2 ITSN2	9.40e-06	27	31	3	int:PIK3AP1
Interaction	GAREM1 interactions	PLCG1 NCK2 ITSN2	9.40e-06	27	31	3	int:GAREM1
Interaction	WAS interactions	NCK1 PLCG1 NCK2 ITSN2	1.02e-05	89	31	4	int:WAS
Interaction	CCL4L2 interactions	COMT FAM209A CATSPER4	1.91e-05	34	31	3	int:CCL4L2
Interaction	NHSL3 interactions	NCK1 PLCG1 PPP1R13L NCK2	2.62e-05	113	31	4	int:NHSL3
Interaction	SOS1 interactions	NCK1 PLCG1 NCK2 ITSN2	3.01e-05	117	31	4	int:SOS1
Interaction	WIPF2 interactions	NCK1 NCK2 ITSN2	3.90e-05	43	31	3	int:WIPF2
Interaction	WIPF1 interactions	NCK1 NCK2 ITSN2	5.44e-05	48	31	3	int:WIPF1
Interaction	BLNK interactions	NCK1 PLCG1 NCK2	5.44e-05	48	31	3	int:BLNK
Interaction	NCKIPSD interactions	NCK1 PLCG1 NCK2 ITSN2	5.58e-05	137	31	4	int:NCKIPSD
Interaction	SOCS7 interactions	NCK1 PLCG1 NCK2	5.79e-05	49	31	3	int:SOCS7
Interaction	FGFR4 interactions	NBEA NCK1 SH3PXD2B PLCG1 NCK2 ITSN2	6.06e-05	458	31	6	int:FGFR4
Interaction	LCP2 interactions	NCK1 PLCG1 NCK2	8.19e-05	55	31	3	int:LCP2
Interaction	SOS2 interactions	NCK1 PLCG1 ITSN2	1.01e-04	59	31	3	int:SOS2
Interaction	DOK1 interactions	NCK1 PLCG1 NCK2	1.01e-04	59	31	3	int:DOK1
Interaction	SEMA6A interactions	NCK1 NCK2 ITSN2	1.23e-04	63	31	3	int:SEMA6A
Interaction	TMEM14C interactions	COMT FAM209A ELOVL7	1.35e-04	65	31	3	int:TMEM14C
Interaction	MYADML2 interactions	COMT FAM209A	1.50e-04	12	31	2	int:MYADML2
Interaction	ADAM15 interactions	NCK1 ECEL1 SH3PXD2A	1.61e-04	69	31	3	int:ADAM15
Interaction	SYN1 interactions	PLCG1 ITSN2 CNTNAP2	2.23e-04	77	31	3	int:SYN1
Interaction	KHDRBS1 interactions	NCK1 PLCG1 SH3PXD2A NCK2 ITSN2	2.42e-04	373	31	5	int:KHDRBS1
Interaction	NIPA2 interactions	NIPAL1 NIPA2	2.71e-04	16	31	2	int:NIPA2
Interaction	FGFR1 interactions	NBEA NCK1 SH3PXD2B PLCG1 NCK2 ITSN2	3.50e-04	632	31	6	int:FGFR1
Interaction	NCK1 interactions	NCK1 SH3PXD2B PLCG1 NCK2	5.10e-04	244	31	4	int:NCK1
Interaction	DAB1 interactions	NCK1 PLCG1 NCK2	5.87e-04	107	31	3	int:DAB1
Interaction	ABL2 interactions	NCK1 PPP1R13L NCK2	5.87e-04	107	31	3	int:ABL2
Interaction	SULT1A3 interactions	SULT1C2 SULT1C3	6.19e-04	24	31	2	int:SULT1A3
Interaction	CBLB interactions	NCK1 NCK2 ITSN2	7.24e-04	115	31	3	int:CBLB
Interaction	DOK2 interactions	NCK1 PLCG1 NCK2	7.43e-04	116	31	3	int:DOK2
Interaction	WASL interactions	NCK1 NCK2 ITSN2	7.61e-04	117	31	3	int:WASL
Cytoband	Ensembl 112 genes in cytogenetic band chr2q12	SULT1C2 SULT1C3 NCK2	2.88e-05	82	33	3	chr2q12
Cytoband	20q13.31	FAM209A FAM209B	5.97e-05	16	33	2	20q13.31
Cytoband	2q12.3	SULT1C2 SULT1C3	6.77e-05	17	33	2	2q12.3
Cytoband	5q35.1	SMIM23 SH3PXD2B	3.47e-04	38	33	2	5q35.1
GeneFamily	Sulfotransferases, cytosolic	SULT1C2 SULT1C3	6.64e-05	14	16	2	762
GeneFamily	SH2 domain containing	NCK1 PLCG1 NCK2	8.99e-05	101	16	3	741
GeneFamily	EF-hand domain containing	PLCG1 ITSN2	1.57e-02	219	16	2	863
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ECEL1 ISM2 ELOVL7 FAM209B	4.87e-06	153	33	4	65641cc82883716dba0fefb749a30174a63f4da5
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SI SULT1C2 GYS2 ELOVL7	8.29e-06	175	33	4	6759d200a133034756de9cdf2d5daceca927aac9
Disease	hereditary spastic paraplegia (implicated_via_orthology)	NIPAL1 NIPA2 PNPLA7	1.26e-05	43	31	3	DOID:2476 (implicated_via_orthology)
Disease	autism spectrum disorder (is_implicated_in)	COMT CNTNAP2	1.27e-04	16	31	2	DOID:0060041 (is_implicated_in)
Disease	cytomegalovirus virus reactivation, response to allogeneic hematopoietic stem cell transplant	FAM209A FAM209B	1.81e-04	19	31	2	EFO_0007044, EFO_0020106
Disease	Albuminuria	NCK1 NCK2	2.91e-04	24	31	2	C0001925
Disease	Nephrotic Syndrome	NCK1 NCK2	3.69e-04	27	31	2	C0027726
Disease	apolipoprotein B measurement	PGS1 NCK1 PLCG1 COMT PPP1R13L	5.91e-04	663	31	5	EFO_0004615
Disease	Proteinuria	NCK1 NCK2	9.39e-04	43	31	2	C0033687
Disease	Heschl's gyrus morphology measurement	FAM209A FAM209B	1.42e-03	53	31	2	EFO_0005852
Disease	electrocardiography	SH3PXD2B MESP2 SH3PXD2A CNTNAP2	2.20e-03	530	31	4	EFO_0004327
Disease	Autistic Disorder	NBEA COMT CNTNAP2	2.56e-03	261	31	3	C0004352
Disease	schizophrenia (is_implicated_in)	COMT CNTNAP2	3.05e-03	78	31	2	DOID:5419 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
HTQGWLGSKWLWLLF	FAM209A	51	Q5JX71
LLGWLNGFWIFWKDG	CATSPER4	141	Q7RTX7
GGHGATGGWKLWSLW	ADGRB1	256	O14514
GYSAWNLDRWKGDLW	GYS2	121	P54840
GGAGALWSQYWTLLW	CCDC142	296	Q17RM4
QENWWFGEVHGGRGW	ITSN2	931	Q9NZM3
DGWWRGSYNGQVGWF	NCK1	141	P16333
DGWWRGSYNGQIGWF	NCK2	146	O43639
EYWVGWFDRWGDKHH	GLB1L3	301	Q8NCI6
GWGKLVFSDGENLWW	AQP7P3	241	A6NL99
LGHDHWIFAQGWGWA	MESP2	11	Q0VG99
WLPALWSFLWGDYKG	ISM2	241	Q6H9L7
EYWRRGWTFHAKGLW	PGS1	456	Q32NB8
HTQGWLGSKWLWLLF	FAM209B	51	Q5JX69
AGQGGHAYLKEWLWW	NIPA2	46	Q8N8Q9
WGGQYDRSGNLLHWW	ECEL1	621	O95672
NYGDALSGWWLLWKR	PNPLA7	1116	Q6ZV29
LRHWGWGLCLIGWNE	COMT	26	P21964
WTWWFGVKFAAGGLG	ELOVL7	156	A1L3X0
DYWIVKNSWGTGWGE	CTSC	421	P53634
WWVGKANEKHYYWGG	CNTNAP2	706	Q9UHC6
TDWWWAALHGQEGYV	PPP1R13L	796	Q8WUF5
QGGHSYLKEWLWWVG	NIPAL1	106	Q6NVV3
VVGGSWFDHVKGWWA	SULT1C3	176	Q6IMI6
HAIKYEWGGWRVWVD	NBEA	926	Q8NFP9
WEWAWALGREHKGGE	SMIM23	146	A6NLE4
GRWGGHWLGDNYARW	SI	1491	P14410
WGANGLARGIWMWSH	RNF112	216	Q9ULX5
EGWWYIRYLGKEGWA	SH3PXD2A	301	Q5TCZ1
EGWWKIRYQGKEGWA	SH3PXD2B	256	A1X283
GKVVWGSWFDHVKGW	SULT1C2	166	O00338
GGWWRGDYGGKKQLW	PLCG1	826	P19174
WGKPGDLWNLGIQWH	PSME4	756	Q14997