Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein methyltransferase activity

METTL9 SETD7 PRDM6 NSD3

3.15e-04103634GO:0008276
GeneOntologyMolecularFunctionN-methyltransferase activity

METTL9 SETD7 PRDM6 NSD3

3.39e-04105634GO:0008170
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF600 ZNF695 ZNF33A ZNF33B ZNF674 ZNF256 NFX1 ZNF620 NLRC5 ZNF616 ZNF606 ZNF844 ZNF529

5.35e-0414596313GO:0000977
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

SETD7 PRDM6 NSD3

1.30e-0368633GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

SETD7 PRDM6 NSD3

1.35e-0369633GO:0016278
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF600 ZNF695 ZNF33A ZNF33B ZNF674 ZNF256 NFX1 ZNF620 ZNF616 ZNF606 ZNF844 ZNF529

1.36e-0314126312GO:0000981
GeneOntologyMolecularFunctionhistone methyltransferase activity

SETD7 PRDM6 NSD3

1.47e-0371633GO:0042054
GeneOntologyBiologicalProcessregulation of activation of membrane attack complex

CD59 C6 CR1

9.82e-084613GO:0001969
GeneOntologyBiologicalProcessactivation of membrane attack complex

CD59 C6 CR1

4.89e-076613GO:0001905
GeneOntologyBiologicalProcessnegative regulation of activation of membrane attack complex

CD59 CR1

8.60e-062612GO:0001971
GeneOntologyBiologicalProcesspositive regulation of activation of membrane attack complex

C6 CR1

2.58e-053612GO:0001970
GeneOntologyBiologicalProcessregulation of complement activation

CD59 C6 CR1

6.84e-0527613GO:0030449
GeneOntologyBiologicalProcessnegative regulation of complement-dependent cytotoxicity

CD59 CR1

8.55e-055612GO:1903660
DomainKRAB

ZNF695 ZNF33A ZNF33B ZNF674 ZNF256 ZNF620 ZNF616 ZNF235 ZNF606 ZNF844 ZNF529

3.30e-083586411PS50805
DomainKRAB

ZNF695 ZNF33A ZNF33B ZNF674 ZNF256 ZNF620 ZNF616 ZNF235 ZNF606 ZNF844 ZNF529

3.30e-083586411PF01352
DomainKRAB

ZNF695 ZNF33A ZNF33B ZNF674 ZNF256 ZNF620 ZNF616 ZNF235 ZNF606 ZNF844 ZNF529

4.50e-083696411SM00349
DomainKRAB

ZNF695 ZNF33A ZNF33B ZNF674 ZNF256 ZNF620 ZNF616 ZNF235 ZNF606 ZNF844 ZNF529

4.62e-083706411IPR001909
DomainZINC_FINGER_C2H2_2

ZNF600 ZNF695 ZNF33A ZNF33B ZNF674 ZNF256 ZNF620 ZNF616 ZNF235 ZNF606 ZC3H7B ZNF844 ZNF529 PRDM6

2.77e-077756414PS50157
DomainZINC_FINGER_C2H2_1

ZNF600 ZNF695 ZNF33A ZNF33B ZNF674 ZNF256 ZNF620 ZNF616 ZNF235 ZNF606 ZC3H7B ZNF844 ZNF529 PRDM6

2.86e-077776414PS00028
DomainZnf_C2H2-like

ZNF600 ZNF695 ZNF33A ZNF33B ZNF674 ZNF256 ZNF620 ZNF616 ZNF235 ZNF606 ZC3H7B ZNF844 ZNF529 PRDM6

3.83e-077966414IPR015880
Domain-

ZNF600 ZNF695 ZNF33A ZNF33B ZNF674 ZNF256 ZNF620 ZNF616 ZNF235 ZNF606 ZNF844 ZNF529 PRDM6

4.11e-0767964133.30.160.60
DomainZnf_C2H2

ZNF600 ZNF695 ZNF33A ZNF33B ZNF674 ZNF256 ZNF620 ZNF616 ZNF235 ZNF606 ZC3H7B ZNF844 ZNF529 PRDM6

4.39e-078056414IPR007087
DomainZnF_C2H2

ZNF600 ZNF695 ZNF33A ZNF33B ZNF674 ZNF256 ZNF620 ZNF616 ZNF235 ZNF606 ZC3H7B ZNF844 ZNF529 PRDM6

4.59e-078086414SM00355
Domainzf-C2H2

ZNF600 ZNF695 ZNF33A ZNF33B ZNF674 ZNF256 ZNF620 ZNF616 ZNF235 ZNF606 ZNF844 ZNF529 PRDM6

5.18e-076936413PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF600 ZNF695 ZNF33A ZNF33B ZNF674 ZNF256 ZNF620 ZNF616 ZNF235 ZNF606 ZNF844 ZNF529 PRDM6

5.26e-076946413IPR013087
Domainzf-C2H2_6

ZNF600 ZNF695 ZNF256 ZNF620 ZNF616 ZNF606 ZNF844

9.71e-05314647PF13912
DomainSET

SETD7 PRDM6 NSD3

3.73e-0441643PF00856
DomainAllrgn_V5/Tpx1_CS

GLIPR1 PI16

5.11e-0410642IPR018244
DomainSET

SETD7 PRDM6 NSD3

5.24e-0446643SM00317
DomainCRISP_1

GLIPR1 PI16

6.23e-0411642PS01009
DomainCRISP_2

GLIPR1 PI16

6.23e-0411642PS01010
DomainSET_dom

SETD7 PRDM6 NSD3

6.70e-0450643IPR001214
DomainSET

SETD7 PRDM6 NSD3

6.70e-0450643PS50280
DomainLRR_6

FBXL16 NLRC5 NLRP8

8.87e-0455643PF13516
Domain-

GLIPR1 PI16

1.18e-03156423.40.33.10
DomainCAP

GLIPR1 PI16

1.18e-0315642PF00188
DomainCAP_domain

GLIPR1 PI16

1.18e-0315642IPR014044
DomainSCP

GLIPR1 PI16

1.18e-0315642SM00198
DomainAllrgn_V5/Tpx1

GLIPR1 PI16

1.18e-0315642IPR001283
DomainLeu-rich_rpt_Cys-con_subtyp

FBXL16 NLRC5

1.90e-0319642IPR006553
DomainLRR_CC

FBXL16 NLRC5

1.90e-0319642SM00367
DomainNACHT

NLRC5 NLRP8

2.79e-0323642PS50837
DomainNACHT_NTPase

NLRC5 NLRP8

2.79e-0323642IPR007111
DomainGal_Oxidase_b-propeller

KEAP1 KLHDC10

6.04e-0334642IPR015916
Pubmed

Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury.

CD59 C6 CR1

4.95e-07964318947875
Pubmed

Reduced Terminal Complement Complex Formation in Mice Manifests in Low Bone Mass and Impaired Fracture Healing.

CD59 C6

3.33e-06264230339839
Pubmed

Anaemia & expression levels of CD35, CD55 & CD59 on red blood cells in Plasmodium falciparum malaria patients from India.

CD59 CR1

9.99e-06364221727667
Pubmed

[Hepatitis B virus X protein upregulates the expression of CD59 and Crry in mouse podocytes].

CD59 CR1

9.99e-06364221215189
Pubmed

The membrane attack complex of complement drives the progression of atherosclerosis in apolipoprotein E knockout mice.

CD59 C6

9.99e-06364219959238
Pubmed

Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function.

NFX1 KEAP1

9.99e-06364216687406
Pubmed

Altered Expression of Complement Regulatory Proteins CD35, CD46, CD55, and CD59 on Leukocyte Subsets in Individuals Suffering From Coronary Artery Disease.

CD59 CR1

9.99e-06364231555286
Pubmed

Regulation of mouse steroidogenesis by WHISTLE and JMJD1C through histone methylation balance.

JMJD1C NSD3

9.99e-06364220530532
Pubmed

The alternative complement pathway propagates inflammation and injury in murine ischemic stroke.

CD59 C6

2.00e-05464223028050
Pubmed

FBX8 degrades GSTP1 through ubiquitination to suppress colorectal cancer progression.

FBXO8 NFX1

2.00e-05464231024008
Pubmed

Mouse CD4+ CD25+ T regulatory cells are protected from autologous complement mediated injury by Crry and CD59.

CD59 CR1

2.00e-05464219281793
Pubmed

Use of complement regulators, CD35, CD46, CD55, and CD59, on leukocytes as markers for diagnosis of viral and bacterial infections.

CD59 CR1

2.00e-05464223376460
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF33A ZNF33B ZNF620 ZNF235 ZNF529

2.15e-0518164537372979
Pubmed

Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.

CD59 C6 CR1

2.57e-053164319344414
Pubmed

Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.

CD59 C6 CR1

2.84e-053264318842294
Pubmed

Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution.

ZNF33A ZNF33B

3.32e-0556428464732
Pubmed

Expression levels of CD47, CD35, CD55, and CD59 on red blood cells and signal-regulatory protein-alpha,beta on monocytes from patients with warm autoimmune hemolytic anemia.

CD59 CR1

3.32e-05564218954403
Pubmed

Crry, but not CD59 and DAF, is indispensable for murine erythrocyte protection in vivo from spontaneous complement attack.

CD59 CR1

3.32e-05564211986227
Pubmed

Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices.

IPCEF1 ARAP1

4.98e-05664211804589
Pubmed

Absence of CD59 exacerbates systemic autoimmunity in MRL/lpr mice.

CD59 CR1

4.98e-05664223109726
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

USP34 TRANK1 FLYWCH1 SETD7 KEAP1 ZC3H7B ARAP1

5.32e-0552964714621295
Pubmed

The regulation of the complement system: insights from genetically-engineered mice.

CD59 CR1

6.96e-05764212914820
Pubmed

Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.

ZNF695 ZNF616 ZNF844

1.03e-04496439630514
Pubmed

ARAP1 association with CIN85 affects epidermal growth factor receptor endocytic trafficking.

TES ARAP1

1.19e-04964221275903
Pubmed

Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures.

FBXL16 TRANK1 PRKCQ

1.30e-045364336265442
Pubmed

Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.

ZSWIM2 PRKCQ GPR160 PML

1.40e-0414264419851296
Pubmed

Association of genetic variants with hemorrhagic stroke in Japanese individuals.

ZSWIM2 PRKCQ GPR160 PML

1.44e-0414364420198315
Pubmed

Circulating AIM prevents hepatocellular carcinoma through complement activation.

CD59 CR1

1.49e-041064225284781
Pubmed

Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis.

CD59 CR1

1.81e-041164223204401
Pubmed

Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg.

CD59 CR1

2.17e-041264218524992
Pubmed

Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites.

FYCO1 KEAP1

2.17e-041264224089205
Pubmed

CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1.

TES CD59 HMGCS1

2.29e-046464336369321
Pubmed

Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering.

ZNF33A ZNF33B

2.99e-04146422014798
Pubmed

Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.

EXO1 CPT1B PML NLRP8

3.39e-0417964419074885
Pubmed

Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.

YPEL3 PML

5.00e-041864226334721
Pubmed

Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.

C6 CR1

5.59e-041964220459687
Pubmed

ATRX proximal protein associations boast roles beyond histone deposition.

FLYWCH1 NSD3 PML

6.43e-049164334780483
Pubmed

FoxP1 orchestration of ASD-relevant signaling pathways in the striatum.

FBXL16 SPHKAP

7.52e-042264226494785
Pubmed

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

USP34 SACS ARAP1

8.71e-041016439872452
Pubmed

Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.

FYCO1 KEAP1

1.05e-032664224067654
Pubmed

A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.

NFX1 ZSWIM2 PML

1.36e-0311864319690564
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

LENG8 TES NFX1 JMJD1C

1.42e-0326364434702444
Pubmed

Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages.

ZNF600 ZNF844

1.60e-033264226142281
Pubmed

An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.

ZSWIM2 PRDM6

1.70e-033364230783098
Pubmed

Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage.

TES CD59 KEAP1

1.84e-0313164328031328
InteractionTRIM28 interactions

ZNF600 TES ZNF695 ZNF33A ZNF33B ZNF674 ZNF256 NFX1 ZNF620 ZNF616 LASP1 KEAP1 ZNF235 ZC3H7B ZNF529 PML

8.42e-0614746316int:TRIM28
CytobandEnsembl 112 genes in cytogenetic band chr19q13

LENG8 ZNF600 ZNF256 ZNF616 ZNF235 ZNF606 ZNF529 NLRP8

2.46e-041192648chr19q13
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF600 ZNF695 ZNF33A ZNF33B ZNF674 ZNF256 ZNF620 ZNF616 ZNF235 ZNF606 ZNF844 ZNF529 PRDM6

8.32e-08718521328
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

SETD7 PRDM6 NSD3

1.26e-0434523487
GeneFamilyComplement system|Sushi domain containing

CD59 C6 CR1

1.50e-0436523492
GeneFamilyNLR family

NLRC5 NLRP8

2.33e-0325522666
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

METTL9 PI16 ABCA13 IPCEF1 LASP1

4.76e-06171645ab21f20ec041cbaacccbd7da4dccdb77ec8bc5c6
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

METTL9 PI16 ABCA13 IPCEF1 LASP1

4.76e-0617164597ad2cfff568a9d006ab1d2e6e00946ee4e3beb3
ToppCellnormal_Lung-B_lymphocytes-Undetermined|B_lymphocytes / Location, Cell class and cell subclass

FLYWCH1 ZNF674 FYCO1 PRKCQ KLHDC10

4.76e-06171645f49dfe11ae66d82125b577c48345a13683d7bb7b
ToppCelldroplet-Marrow-nan-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

YPEL3 TRANK1 ABCA13 IPCEF1 LASP1

4.89e-06172645d354424c1f861b6607dfd63b9724f4c237b30275
ToppCellCV-Mild-6|Mild / Virus stimulation, Condition and Cluster

TES CXorf38 ZNF674 LASP1 ALPK2

5.32e-06175645c4d530dbb37942427c9cd0a1533faeb6a3a45381
ToppCell3'_v3-blood-Lymphocytic_T_CD4-Tregs|blood / Manually curated celltypes from each tissue

PI16 IPCEF1 CD59 PRKCQ NSD3

8.56e-061936452ffe44edf2b02d11a7c10513692eb697a10f911e
ToppCellHippocampus-Neuronal|Hippocampus / BrainAtlas - Mouse McCarroll V32

USP34 FBXL16 TRANK1 FLYWCH1 TMEM59L

8.78e-061946458aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCellMyeloid-Myeloid-E_(Neutrophils)|Myeloid / shred on cell class and cell subclass (v4)

GLIPR1 YPEL3 PI16 IPCEF1

6.45e-051506441bffb8d86b737ac43be902d9468041aef3542f1f
ToppCellfacs-Lung-24m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-natural_killer|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TES SACS PRKCQ GPR160

7.70e-0515764434eb1cbdb023d3e23b2e1695c9c327c21ef1c870
ToppCellfacs-Lung-24m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TES SACS PRKCQ GPR160

7.70e-05157644fc0c222124f59c94d60335f849554eaa4062f8c7
ToppCellfacs-Lung-24m-Hematologic-Lymphocytic_NK_ILC|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TES SACS PRKCQ GPR160

7.70e-0515764440b08ace1d9ea7951886f5fed76ac57e9175436b
ToppCellCV-Mild-6|CV / Virus stimulation, Condition and Cluster

TES CXorf38 ZNF674 ALPK2

9.78e-05167644cf2ed0b6d17a16f9a2318879ce8856d5983ad3cf
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_1|356C / Donor, Lineage, Cell class and subclass (all cells)

YPEL3 IPCEF1 PRKCQ NSD3

1.12e-04173644e3cb7c8c09f937da6b8d673e9adfec5d94a15548
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.4.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLYWCH1 LTO1 METTL9 CPT1B

1.20e-0417664423bde9b9b4977b8cfe7d2a3ab8e8088ce9c6012c
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FBXL16 IPCEF1 ZNF674 PRKCQ

1.22e-0417764464b8f665fdaf975558af2ad7d9b54d206de8350c
ToppCellTCGA-Head_and_Esophagus-Solid_Tissue_Normal|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

PI16 FYCO1 C6 ZNF844

1.31e-04180644806e2f6138b630b9d7c41df75ec208e0a2298ee0
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

TRANK1 NLRC5 JMJD1C PML

1.39e-041836448f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCellhuman_hepatoblastoma-NK.T_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

IPCEF1 ENTPD1 NLRC5 PRKCQ

1.54e-0418864471b7599e7e1d63cc0c8518c0501533755951d58f
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

GLIPR1 TES ENTPD1 TMEM59L

1.54e-0418864474f7d216209cabdc96b2d46685b0ae017fdcc8fc
ToppCell343B-Lymphocytic-ILC-ILC-1|343B / Donor, Lineage, Cell class and subclass (all cells)

CXorf38 IPCEF1 PRKCQ ZNF529

1.54e-041886448f6b45ad82bde65e044d17f0edbc3db90d457915
ToppCellfacs-Heart-LV-3m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FYCO1 ZNF235 CPT1B FRMD5

1.54e-0418864440ce7125fca6f6b6b5cc1637c87d43c29b08f4f1
ToppCellfacs-Heart-LV-3m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FYCO1 ZNF235 CPT1B FRMD5

1.54e-04188644ba7f7ce034c0f42742bf2461f68f8d343ee593a5
ToppCellnormal_Pleural_Fluid-T/NK_cells-Treg|T/NK_cells / Location, Cell class and cell subclass

ENTPD1 CD59 SETD7 NSD3

1.61e-04190644519356c4925b5b6647e7d763d4084cd9b2e94f0a
ToppCellPSB-critical-LOC-Lymphoid-NK|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

GLIPR1 IPCEF1 ENTPD1 PRKCQ

1.61e-04190644e1b5d76edd4c1b95c0a7b94284a65043ab895e67
ToppCellcontrol-Myeloid-Neutrophils_1|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

YPEL3 TRANK1 JMJD1C ARAP1

1.64e-04191644db1b3cd07d7d190155b2d14e82e1d124975fbd0b
ToppCellsevere-Lymphocytic-CD4_T_cells_3|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PI16 CD59 PRKCQ SETD7

1.64e-04191644afff6bfae9a2f1e17d2731315e7fe63c4601679f
ToppCellCOVID-19_Severe-Treg|COVID-19_Severe / Disease condition and Cell class

PI16 ENTPD1 CD59 SETD7

1.64e-0419164406fdd76ea13b93e29959c745698b57af6746aaeb
ToppCellSevere-Treg|World / Disease group and Cell class

IPCEF1 ENTPD1 SETD7 NSD3

1.64e-041916440a80b8c317e8da4d4722cfd13cdabc32b58021eb
ToppCellBAL-Severe-Lymphocyte-T/NK-CD4+_T-Treg-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

YPEL3 IPCEF1 PRKCQ NSD3

1.67e-04192644d85a785a12076e34c404171363a647f318926b18
ToppCellHealthy-Treg|Healthy / disease group, cell group and cell class

FBXL16 PI16 PRKCQ NSD3

1.67e-041926449d3795a64bf0c62f460d80730c5615869fc46933
ToppCellBAL-Severe-Lymphocyte-T/NK-CD4+_T-Treg|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

YPEL3 IPCEF1 PRKCQ NSD3

1.67e-04192644230f3090607a62bb6d1e1f4b0341ee96d93f1c00
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GLIPR1 TES ENTPD1 PRDM6

1.71e-041936444aa976b596830b585e8d9c808d5072ed23d13a7c
ToppCellChildren_(3_yrs)-Immune-monocyte-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

GLIPR1 IPCEF1 ENTPD1 CR1

1.71e-0419364458e1930a1d80ad3729ab9604ac8ebf7308232a3d
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GLIPR1 TES ENTPD1 PRDM6

1.71e-041936445578f7cb3ec68c9a38cc5304b618b81283024d5e
ToppCellHealthy-Treg|World / disease group, cell group and cell class

FBXL16 PI16 PRKCQ NSD3

1.71e-04193644e22bfcd170ba23e313512f0f07c658fcf6ae1b97
ToppCellControl-Classical_Monocyte|Control / Disease condition and Cell class

YPEL3 METTL9 ENTPD1 CR1

1.74e-041946449e33e1b54b4114f9e6981819834bb796ed7192b5
ToppCellsevere-Myeloid-Neutrophils_3|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

YPEL3 METTL9 ENTPD1 CR1

1.74e-041946441f8edab1c8ba48bc0114429ea47aab378b5830b7
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic-lymphocyte-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

NRDE2 PRKCQ ZNF844 PRIMPOL

1.74e-041946448f4b63b0b9a40765205e4ca6bd94a675a83dbe3d
ToppCellSevere-Treg|Severe / Disease group and Cell class

IPCEF1 ENTPD1 SETD7 NSD3

1.74e-041946447d232d87262ec5f505901345da5113cabf821321
ToppCellhuman_hepatoblastoma-NK.T_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

IPCEF1 ENTPD1 NLRC5 PRKCQ

1.74e-04194644997b02a22d7c89a8fd5615bb79a2a8a34fc3fee6
ToppCellcontrol-Myeloid-Neutrophils_3|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

YPEL3 ENTPD1 CR1 GPR160

1.74e-041946442218e6677dc6781a6e4ef3a315f2298cc2cd9df2
ToppCellCOVID-19-Lymphoid-Tregs|Lymphoid / Condition, Lineage and Cell class

IPCEF1 ENTPD1 SETD7 NSD3

1.77e-041956449ad844d9d5aac39d133ae8ab9c4839300f08064c
ToppCellControl-Treg|Control / Disease condition and Cell class

PI16 ENTPD1 CD59 SETD7

1.77e-04195644bbe9789eb2c17f43de55b2e6d01d1093c64dc666
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Mesenchymal-Unfolded_protein_responsible_cell|GW26 / Sample Type, Dataset, Time_group, and Cell type.

ZNF695 C6 CPT1B PRDM6

1.77e-041956449873de83b67e9645112897d3391c2d9afaa9970e
ToppCellCOVID-19-Lymphoid-Tregs|COVID-19 / Condition, Lineage and Cell class

YPEL3 IPCEF1 PRKCQ NSD3

1.77e-04195644284cfff4d59ecc1430997b118de17fee167dcbb1
ToppCellCOVID_non-vent-Lymphocytic-T_cell-CD8+_Memory_T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

ZNF600 TRANK1 NLRC5 PRKCQ

1.84e-04197644836061acd7f0d5de89b16f52ec679bdf09eac9db
ToppCellSevere_COVID-19-T/NK-CD4+_T_2|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

YPEL3 IPCEF1 PRKCQ NSD3

1.88e-04198644c8c9343c19198b6534f8f07e74405e29b3a164bf
ToppCellInfluenza-Influenza_Severe-Lymphocyte-T/NK-Treg|Influenza_Severe / Disease, condition lineage and cell class

FBXL16 SACS PI16 PRKCQ

1.88e-04198644e377fa0215f338f86ee2903ce3fa57cea805a630
ToppCellBAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_2-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

YPEL3 IPCEF1 PRKCQ NSD3

1.88e-0419864493773b1abbf46b39e320d628077bf94958b872a4
ToppCellBAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_2|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

YPEL3 IPCEF1 PRKCQ NSD3

1.88e-04198644812ffe7369bf83ae5071970934c8831611db9557
ToppCellTracheal-NucSeq-Immune_Lymphocytic-T-T_CD4-T_reg|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

IPCEF1 ENTPD1 NLRC5 PRKCQ

1.95e-0420064468589705dbc84482b6c0a1a27dd552492c4e8c3d
ToppCellsevere-immature_Neutrophil|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ABCA13 ENTPD1 CD59 GPR160

1.95e-042006445ee43386da8261d2e7602a152e6ba4338d844e08
Druggeldanamycin; Down 200; 1uM; PC3; HT_HG-U133A

ENTPD1 EXO1 CD59 CPT1B ZC3H7B PML

1.57e-051906464452_DN
DrugAmiodarone hydrochloride [19774-82-4]; Down 200; 5.8uM; HL60; HT_HG-U133A

GLIPR1 TRANK1 ZC3H7B TUBD1 TCTN2 PML

1.76e-051946462434_DN
DrugOmeprazole [73590-58-6]; Down 200; 11.6uM; HL60; HT_HG-U133A

TRANK1 ENTPD1 ZC3H7B NSD3 TCTN2 PML

1.76e-051946462467_DN
DrugPropoxycaine hydrochloride [550-83-4]; Down 200; 12uM; HL60; HT_HG-U133A

TRANK1 CD59 KLHDC10 ZC3H7B CR1 NSD3

1.92e-051976466161_DN
DrugParomomycin sulfate [1263-89-4]; Up 200; 5.6uM; MCF7; HT_HG-U133A

ENTPD1 PRKCQ ZC3H7B CR1 ARAP1 PML

1.98e-051986463356_UP
DrugZomepirac sodium salt [64092-48-4]; Down 200; 12.8uM; HL60; HT_HG-U133A

GLIPR1 CD59 CR1 TUBD1 TCTN2 PML

2.03e-051996462713_DN
Diseaseinterleukin 12 measurement

SACS NFX1 JMJD1C

2.11e-0453643EFO_0004753
DiseaseImpaired cognition

EIF2B5 CR1

4.14e-0414642C0338656
Diseaseglomerulonephritis (implicated_via_orthology)

CD59 C6

6.17e-0417642DOID:2921 (implicated_via_orthology)
Diseasealpha fetoprotein measurement

USP34 EXO1 JMJD1C

1.35e-03100643EFO_0010583
Diseasecholesteryl esters to total lipids in large LDL percentage

NLRC5 JMJD1C

2.07e-0331642EFO_0022249
Diseasesleep duration, high density lipoprotein cholesterol measurement

NLRC5 JMJD1C FRMD5

2.34e-03121643EFO_0004612, EFO_0005271
DiseaseComplement deficiency disease

CD59 C6

2.34e-0333642C0272242
Diseasehypothyroidism

TRANK1 PRKCQ KEAP1 ZC3H7B

3.39e-03284644EFO_0004705
Diseaseascending aortic diameter

ENTPD1 JMJD1C PRDM6

3.53e-03140643EFO_0021787
Diseasecholesterol to total lipids in large VLDL percentage

NLRC5 JMJD1C

4.32e-0345642EFO_0022236
Diseasediabetic retinopathy (biomarker_via_orthology)

CD59 KEAP1

4.32e-0345642DOID:8947 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
FAKAYARQCVWGHNK

PI16

66

Q6UXB8
YVKEAEQQACSHGCW

TMEM59L

111

Q9UK28
EAGQKCCTFQHWVYQ

ALPK2

2056

Q86TB3
YTVKVWLCKEANQHC

ABCA13

4951

Q86UQ4
AGLQVYNKCWKFEHC

CD59

56

P13987
YNKCWKFEHCNFNDV

CD59

61

P13987
RCYSVYCKKIHAQWQ

HMGCS1

231

Q01581
CHEFVWGLNKQGYQC

PRKCQ

176

Q04759
CKKVCGHYTQVVWAD

GLIPR1

131

P48060
KRWCAFYFHCQEVNQ

NLRP8

236

Q86W28
WDYFCACLAKVKGAN

FYCO1

71

Q9BQS8
DKVYWKCRQHAELGC

FLYWCH1

141

Q4VC44
ATLFNIHWVCQKCGF

JMJD1C

1851

Q15652
VKCHWKEKQDYAFAC

LENG8

586

Q96PV6
EKVNCLDKFWHKACF

LASP1

16

Q14847
TFVFCCWKAAQIKEH

EIF2B5

91

Q13144
GNDVHVCNVKYKRWA

KLHDC10

181

Q6PID8
NCNNFCLWKQYAHLE

NRDE2

776

Q9H7Z3
LCKSTWGHCSIYNKN

FBXO8

111

Q9NRD0
SCYHVFHLNCIKKWA

NFX1

376

Q12986
KENHQWYVCNREKLC

METTL9

51

Q9H1A3
HSFLCYGKDQALWQK

ENTPD1

251

P49961
LCQKWAEGHLNCFQA

NLRC5

241

Q86WI3
HLWKCGQCFKTFTQR

PRDM6

471

Q9NQX0
VYWFNCHKLNLKDIG

GPR160

291

Q9UJ42
KHLWKCGIENQAFYK

FRMD5

281

Q7Z6J6
CKDLGHADCQGWLYK

IPCEF1

36

Q8WWN9
INKGQACFCDHYAWT

C6

16

P13671
CTDQGIWSQLDHYCK

CR1

1891

P17927
DSKWCQEHFLNYKGL

DHX35

561

Q9H5Z1
YQGFAFAWKCLLHSC

LTO1

56

Q8WV07
CESEVFHACINWVKY

KEAP1

241

Q14145
FHACINWVKYDCEQR

KEAP1

246

Q14145
NCAEYKNWVKAGHCL

CXorf38

11

Q8TB03
HKNANEWVCFKCYLS

SACS

4466

Q9NZJ4
KALLHGNCYNRWFDK

CPT1B

441

Q92523
VWYQKCHDPVCKAEN

PRIMPOL

441

Q96LW4
WCCQVQDFGLKHLLA

FBXL16

406

Q8N461
WKVGDIFHAVVQYCK

SPHKAP

1666

Q2M3C7
FWKNEKLYCGRHYCD

TES

281

Q9UGI8
LLCAKCFEAHQWFLK

PML

146

P29590
FKGQYKDNIRHGVCW

SETD7

106

Q8WTS6
TYCWLHKGAIACAEK

EXO1

31

Q9UQ84
TEKHEKQQWYLCCDT

ARAP1

1366

Q96P48
AQSGQWKYGQHACFC

TUBD1

81

Q9UJT1
WKYGQHACFCQKQGS

TUBD1

86

Q9UJT1
CGKAFNWFSYLTNHK

ZNF695

441

Q8IW36
WRIHTGEKAYKCNEC

ZNF616

456

Q08AN1
HFQCNQCGKTFWEKS

ZNF33B

356

Q06732
SVKNHYNWGECVKAF

ZNF256

206

Q9Y2P7
FHTGEKLYECNECWK

ZNF620

301

Q6ZNG0
CWNCNDCKAGKKLHY

NSD3

946

Q9BZ95
YECKQCGKAFRWFHS

ZNF844

281

Q08AG5
KHFECNECGKAFWEK

ZNF33A

326

Q06730
FHRKCIDNWLFHKCN

ZSWIM2

366

Q8NEG5
CHYLKNDNCWTTKNE

TMEM87B

121

Q96K49
WTQRQCLCCFKEYKH

USP34

41

Q70CQ2
KIHTGGKNYECNQCW

ZNF529

191

Q6P280
GDYYAKHQCWKVAAK

TRANK1

1706

O15050
KHQCWKVAAKCYQKG

TRANK1

1711

O15050
DDGCKAYWKVCLHYN

ZNF674

171

Q2M3X9
YKCKVCDKAFAWNSH

ZNF600

386

Q6ZNG1
LQCCGQHNYTDWIKN

TSPAN19

151

P0C672
KKRYWCHECGKGFSQ

ZNF235

316

Q14590
WQYQCGLTCEHKADL

TCTN2

596

Q96GX1
YECNKCGKAFSWNSH

ZNF606

456

Q8WXB4
GYHCWLCGKNSNSKK

ZC3H7B

841

Q9UGR2
DIHCENCKTTLGWKY

YPEL3

76

P61236