Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionKrueppel-associated box domain binding

HDAC1 HDAC2

5.68e-063282GO:0035851
GeneOntologyMolecularFunctionprotein decrotonylase activity

HDAC1 HDAC2

1.89e-055282GO:0160008
GeneOntologyMolecularFunctionhistone decrotonylase activity

HDAC1 HDAC2

1.89e-055282GO:0160009
GeneOntologyMolecularFunctionalpha-amylase activity

AMY2A AMY2B

1.89e-055282GO:0004556
GeneOntologyMolecularFunctionamylase activity

AMY2A AMY2B

2.83e-056282GO:0016160
GeneOntologyMolecularFunctionchloride ion binding

AMY2A AMY2B

2.25e-0416282GO:0031404
GeneOntologyMolecularFunctionhistone deacetylase activity

HDAC1 HDAC2

5.13e-0424282GO:0004407
GeneOntologyMolecularFunctionprotein lysine deacetylase activity

HDAC1 HDAC2

5.58e-0425282GO:0033558
GeneOntologyMolecularFunctionNF-kappaB binding

HDAC1 HDAC2

1.16e-0336282GO:0051059
GeneOntologyMolecularFunctiondeacetylase activity

HDAC1 HDAC2

1.43e-0340282GO:0019213
GeneOntologyMolecularFunctiontranscription corepressor binding

HDAC1 HDAC2

3.09e-0359282GO:0001222
GeneOntologyMolecularFunctioncalcium ion binding

SLC25A24 AMY2A AMY2B EFCAB6 MELK

3.51e-03749285GO:0005509
GeneOntologyMolecularFunctionnucleosomal DNA binding

HDAC1 HDAC2

3.96e-0367282GO:0031492
GeneOntologyMolecularFunctionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

HDAC1 HDAC2

5.74e-0381282GO:0016811
GeneOntologyMolecularFunctionpromoter-specific chromatin binding

HDAC1 HDAC2

6.02e-0383282GO:1990841
GeneOntologyMolecularFunctionnucleosome binding

HDAC1 HDAC2

8.29e-0398282GO:0031491
GeneOntologyBiologicalProcessfungiform papilla formation

HDAC1 HDAC2

9.89e-064272GO:0061198
GeneOntologyBiologicalProcesshair follicle placode formation

HDAC1 HDAC2

2.47e-056272GO:0060789
GeneOntologyBiologicalProcessfungiform papilla morphogenesis

HDAC1 HDAC2

2.47e-056272GO:0061197
GeneOntologyBiologicalProcessfungiform papilla development

HDAC1 HDAC2

3.45e-057272GO:0061196
GeneOntologyBiologicalProcesstongue morphogenesis

HDAC1 HDAC2

1.08e-0412272GO:0043587
GeneOntologyBiologicalProcessembryonic digit morphogenesis

FREM2 HDAC1 HDAC2

1.22e-0474273GO:0042733
GeneOntologyBiologicalProcesslimb development

FREM2 IFT172 HDAC1 HDAC2

1.95e-04224274GO:0060173
GeneOntologyBiologicalProcessappendage development

FREM2 IFT172 HDAC1 HDAC2

1.95e-04224274GO:0048736
GeneOntologyBiologicalProcessectodermal placode morphogenesis

HDAC1 HDAC2

1.96e-0416272GO:0071697
GeneOntologyBiologicalProcesseyelid development in camera-type eye

HDAC1 HDAC2

1.96e-0416272GO:0061029
GeneOntologyBiologicalProcessectodermal placode formation

HDAC1 HDAC2

1.96e-0416272GO:0060788
GeneOntologyBiologicalProcessectodermal placode development

HDAC1 HDAC2

2.49e-0418272GO:0071696
GeneOntologyBiologicalProcessnegative regulation of stem cell population maintenance

HDAC1 HDAC2

5.26e-0426272GO:1902455
GeneOntologyBiologicalProcesstongue development

HDAC1 HDAC2

5.68e-0427272GO:0043586
GeneOntologyBiologicalProcessregulation of signaling receptor activity

PTPRJ HDAC1 HDAC2

6.55e-04131273GO:0010469
GeneOntologyBiologicalProcessregulation of cell fate specification

HDAC1 HDAC2

6.56e-0429272GO:0042659
GeneOntologyBiologicalProcessoligodendrocyte differentiation

PTPRJ HDAC1 HDAC2

7.46e-04137273GO:0048709
GeneOntologyBiologicalProcessnegative regulation of transforming growth factor beta receptor signaling pathway

TGFB3 HDAC1 HDAC2

7.62e-04138273GO:0030512
GeneOntologyBiologicalProcesspositive regulation of signaling receptor activity

HDAC1 HDAC2

8.50e-0433272GO:2000273
GeneOntologyBiologicalProcesspositive regulation of oligodendrocyte differentiation

HDAC1 HDAC2

9.02e-0434272GO:0048714
GeneOntologyBiologicalProcessembryonic limb morphogenesis

FREM2 HDAC1 HDAC2

9.33e-04148273GO:0030326
GeneOntologyBiologicalProcessembryonic appendage morphogenesis

FREM2 HDAC1 HDAC2

9.33e-04148273GO:0035113
GeneOntologyBiologicalProcessodontogenesis

TGFB3 HDAC1 HDAC2

9.89e-04151273GO:0042476
GeneOntologyCellularComponentNuRD complex

HDAC1 HDAC2

2.32e-0417282GO:0016581
GeneOntologyCellularComponentCHD-type complex

HDAC1 HDAC2

2.32e-0417282GO:0090545
GeneOntologyCellularComponentSin3-type complex

HDAC1 HDAC2

3.93e-0422282GO:0070822
DomainA-amylase_C

AMY2A AMY2B

6.50e-063282IPR031319
DomainHis_deacetylse_1

HDAC1 HDAC2

1.30e-054282IPR003084
DomainAamy_C

AMY2A AMY2B

1.30e-054282SM00632
DomainAlpha_amylase

AMY2A AMY2B

1.30e-054282IPR006046
DomainAlpha-amylase_C

AMY2A AMY2B

2.16e-055282PF02806
DomainA-amylase/branching_C

AMY2A AMY2B

2.16e-055282IPR006048
DomainGlyco_hydro_13

AMY2A AMY2B

3.24e-056282IPR015902
DomainAamy

AMY2A AMY2B

4.53e-057282SM00642
DomainAlpha-amylase

AMY2A AMY2B

4.53e-057282PF00128
DomainGlyco_hydro_13_cat_dom

AMY2A AMY2B

4.53e-057282IPR006047
DomainHis_deacetylse_dom

HDAC1 HDAC2

1.18e-0411282IPR023801
DomainHist_deacetyl

HDAC1 HDAC2

1.18e-0411282PF00850
Domain-

HDAC1 HDAC2

1.18e-04112823.40.800.20
DomainHis_deacetylse

HDAC1 HDAC2

1.18e-0411282IPR000286
Domain-

AMY2A AMY2B

1.95e-04142822.60.40.1180
DomainGlyco_hydro_b

AMY2A AMY2B

2.25e-0415282IPR013780
Domain-

AMY2A AMY2B

1.25e-03352823.20.20.80
DomainGlyco_hydro_catalytic_dom

AMY2A AMY2B

1.47e-0338282IPR013781
DomainGlycoside_hydrolase_SF

AMY2A AMY2B

2.85e-0353282IPR017853
PathwayWP_HISTONE_MODIFICATIONS

HDAC1 HDAC2

2.54e-055232MM15874
PathwayREACTOME_P75NTR_NEGATIVELY_REGULATES_CELL_CYCLE_VIA_SC1

HDAC1 HDAC2

3.80e-056232M27072
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_REST_MEDIATED_TRANSCRIPTIONAL_REPRESSION

HDAC1 HDAC2

5.32e-057232M47673
PathwayPID_HEDGEHOG_GLI_PATHWAY

IFT172 HDAC1 HDAC2

6.25e-0548233M219
PathwayREACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE

AMY2A AMY2B

7.09e-058232MM14717
PathwayKEGG_MEDICUS_REFERENCE_GLYCOGEN_DEGRADATION_AMYLASE_

AMY2A AMY2B

9.10e-059232M47622
PathwayREACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE

AMY2A AMY2B

1.39e-0411232M1091
PathwayKEGG_MEDICUS_VARIANT_TEL_AML1_FUSION_TO_TRANSCRIPTIONAL_REPRESSION

HDAC1 HDAC2

1.39e-0411232M47438
PathwayREACTOME_STAT3_NUCLEAR_EVENTS_DOWNSTREAM_OF_ALK_SIGNALING

HDAC1 HDAC2

1.39e-0411232M42523
PathwayKEGG_CHRONIC_MYELOID_LEUKEMIA

TGFB3 HDAC1 HDAC2

2.19e-0473233M321
PathwayBIOCARTA_PRC2_PATHWAY

HDAC1 HDAC2

2.29e-0414232M22025
PathwayBIOCARTA_MEF2D_PATHWAY

HDAC1 HDAC2

3.83e-0418232M5290
PathwayREACTOME_MECP2_REGULATES_NEURONAL_RECEPTORS_AND_CHANNELS

HDAC1 HDAC2

3.83e-0418232M27901
PathwayWP_CALCIUM_MEDIATED_TCELL_APOPTOSIS_INVOLVED_IN_INCLUSION_BODY_MYOSITIS

HDAC1 HDAC2

4.75e-0420232M48330
PathwayREACTOME_DIGESTION

AMY2A AMY2B

5.25e-0421232MM15526
PathwayREACTOME_DIGESTION

AMY2A AMY2B

6.31e-0423232M27790
PathwayREACTOME_DIGESTION_AND_ABSORPTION

AMY2A AMY2B

7.47e-0425232MM15557
PathwayBIOCARTA_CARM_ER_PATHWAY

HDAC1 HDAC2

8.08e-0426232M2499
PathwayKEGG_MEDICUS_REFERENCE_ACTIVATION_OF_PRC2.2_BY_UBIQUITINATION_OF_H2AK119_IN_GERMLINE_GENES

HDAC1 HDAC2

8.72e-0427232M47941
PathwayREACTOME_DIGESTION_AND_ABSORPTION

AMY2A AMY2B

9.38e-0428232M27837
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

HDAC1 HDAC2

9.38e-0428232M6177
PathwayBIOCARTA_G1_PATHWAY

TGFB3 HDAC1

9.38e-0428232M648
PathwayWP_CELL_CYCLE

TGFB3 HDAC1 HDAC2

9.41e-04120233M39650
PathwayKEGG_CELL_CYCLE

TGFB3 HDAC1 HDAC2

1.06e-03125233M7963
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION

HDAC1 HDAC2

1.08e-0330232M27637
PathwayREACTOME_SIGNALING_BY_ALK

HDAC1 HDAC2

1.08e-0330232M42517
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES

HDAC1 HDAC2

1.08e-0330232M27941
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_OF_BROWN_AND_BEIGE_ADIPOCYTE_DIFFERENTIATION

HDAC1 HDAC2

1.15e-0331232M48258
PathwayWP_ETHANOL_EFFECTS_ON_HISTONE_MODIFICATIONS

HDAC1 HDAC2

1.15e-0331232M39714
PathwayWP_INITIATION_OF_TRANSCRIPTION_AND_TRANSLATION_ELONGATION_AT_THE_HIV1_LTR

HDAC1 HDAC2

1.23e-0332232M39521
PathwayREACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY

HDAC1 HDAC2

1.23e-0332232M27900
PathwayWP_EFFECT_OF_PROGERIN_ON_GENES_INVOLVED_IN_PROGERIA

HDAC1 HDAC2

1.64e-0337232M39756
PathwayREACTOME_SIGNALING_BY_HEDGEHOG

BOC ERLEC1 IFT172

1.79e-03150233M27440
PathwayWP_NOTCH_SIGNALING_WP268

HDAC1 HDAC2

2.42e-0345232M39571
PathwayWP_NOTCH_SIGNALING_PATHWAY

HDAC1 HDAC2

2.52e-0346232MM15971
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

HDAC1 HDAC2

2.63e-0347232M7946
PathwayREACTOME_RNA_POLYMERASE_I_TRANSCRIPTION_INITIATION

HDAC1 HDAC2

2.63e-0347232M1095
PathwayREACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

HDAC1 HDAC2

2.74e-0348232M611
PathwayKEGG_STARCH_AND_SUCROSE_METABOLISM

AMY2A AMY2B

3.21e-0352232M14171
PathwayREACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER

HDAC1 HDAC2

3.98e-0358232M29616
PathwayWP_NOTCH_SIGNALING_WP61

HDAC1 HDAC2

4.40e-0361232M39540
PathwayREACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION

HDAC1 HDAC2

4.40e-0361232M27811
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_MECP2

HDAC1 HDAC2

4.68e-0363232M27862
PathwayWP_VEGFAVEGFR2_SIGNALING

FLII ACACA PTPRJ HDAC1

4.81e-03431234M39729
PathwayWP_CILIARY_LANDSCAPE

IFT172 HDAC1 HDAC2

4.95e-03215233M39734
PathwayPID_HDAC_CLASSI_PATHWAY

HDAC1 HDAC2

5.13e-0366232M101
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION

HDAC1 HDAC2

5.13e-0366232M27938
PathwayPID_TELOMERASE_PATHWAY

HDAC1 HDAC2

5.28e-0367232M105
Pubmed

Assignment of LH XVI to chromosome 3 in the mouse.

FREM2 AMY2A AMY2B

1.63e-0872836160178
Pubmed

Histone deacetylases 1 and 2 regulate autophagy flux and skeletal muscle homeostasis in mice.

HDAC1 HDAC2

6.25e-07228222307625
Pubmed

The action of human pancreatic and salivary isoamylases on starch and glycogen.

AMY2A AMY2B

6.25e-072282890964
Pubmed

The lysine deacetylase activity of histone deacetylases 1 and 2 is required to safeguard zygotic genome activation in mice and cattle.

HDAC1 HDAC2

6.25e-07228235575026
Pubmed

Histone hypoacetylation and increased histone deacetylases in peripheral blood mononuclear cells from patients with Graves' disease.

HDAC1 HDAC2

6.25e-07228226116233
Pubmed

Disrupted ectodermal organ morphogenesis in mice with a conditional histone deacetylase 1, 2 deletion in the epidermis.

HDAC1 HDAC2

6.25e-07228223792463
Pubmed

Dynamic distribution of HDAC1 and HDAC2 during mitosis: association with F-actin.

HDAC1 HDAC2

6.25e-07228223280436
Pubmed

Selective Inhibition of HDAC1 and HDAC2 as a Potential Therapeutic Option for B-ALL.

HDAC1 HDAC2

6.25e-07228225688158
Pubmed

Expression and function of histone deacetylases in rheumatoid arthritis synovial fibroblasts.

HDAC1 HDAC2

6.25e-07228219531758
Pubmed

Histone deacetylase 2 (HDAC2) regulates chromosome segregation and kinetochore function via H4K16 deacetylation during oocyte maturation in mouse.

HDAC1 HDAC2

6.25e-07228223516383
Pubmed

Histone deacetylases 1 and 2 are phosphorylated at novel sites during varicella-zoster virus infection.

HDAC1 HDAC2

6.25e-07228219740981
Pubmed

NuRD and SIN3 histone deacetylase complexes in development.

HDAC1 HDAC2

6.25e-07228210904264
Pubmed

HDAC1 and HDAC2 collectively regulate intestinal stem cell homeostasis.

HDAC1 HDAC2

6.25e-07228225648995
Pubmed

Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro.

HDAC1 HDAC2

6.25e-07228231222845
Pubmed

The acetylome regulators Hdac1 and Hdac2 differently modulate intestinal epithelial cell dependent homeostatic responses in experimental colitis.

HDAC1 HDAC2

6.25e-07228224525021
Pubmed

A comparative immunohistochemical study on amylase localization in the rat and human exocrine pancreas.

AMY2A AMY2B

6.25e-07228211376382
Pubmed

Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility.

HDAC1 HDAC2

6.25e-07228217639084
Pubmed

HDA2 and HDA3 are related proteins that interact with and are essential for the activity of the yeast histone deacetylase HDA1.

HDAC1 HDAC2

6.25e-07228211287668
Pubmed

Differential HDAC1/2 network analysis reveals a role for prefoldin/CCT in HDAC1/2 complex assembly.

HDAC1 HDAC2

6.25e-07228230209338
Pubmed

Essential roles of HDAC1 and 2 in lineage development and genome-wide DNA methylation during mouse preimplantation development.

HDAC1 HDAC2

6.25e-07228231533525
Pubmed

HDAC1 and HDAC2 are differentially expressed in endometriosis.

HDAC1 HDAC2

6.25e-07228222344732
Pubmed

Kidney cell type-specific changes in the chromatin and transcriptome landscapes following epithelial Hdac1 and Hdac2 knockdown.

HDAC1 HDAC2

6.25e-07228234890513
Pubmed

Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts.

HDAC1 HDAC2

6.25e-07228232366868
Pubmed

HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells.

HDAC1 HDAC2

6.25e-07228221423190
Pubmed

HDAC1 and HDAC2 independently regulate common and specific intrinsic responses in murine enteroids.

HDAC1 HDAC2

6.25e-07228230926862
Pubmed

Primary macrophages rely on histone deacetylase 1 and 2 expression to induce type I interferon in response to gammaherpesvirus infection.

HDAC1 HDAC2

6.25e-07228224335310
Pubmed

Attenuation of neuronal ferroptosis in intracerebral hemorrhage by inhibiting HDAC1/2: Microglial heterogenization via the Nrf2/HO1 pathway.

HDAC1 HDAC2

6.25e-07228238523117
Pubmed

Trans-regulation of histone deacetylase activities through acetylation.

HDAC1 HDAC2

6.25e-07228219822520
Pubmed

Lysophosphatidic acid protects cancer cells from histone deacetylase (HDAC) inhibitor-induced apoptosis through activation of HDAC.

HDAC1 HDAC2

6.25e-07228218408217
Pubmed

Valproic acid targets HDAC1/2 and HDAC1/PTEN/Akt signalling to inhibit cell proliferation via the induction of autophagy in gastric cancer.

HDAC1 HDAC2

6.25e-07228231692265
Pubmed

HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia.

HDAC1 HDAC2

6.25e-07228228579617
Pubmed

HDAC1 and HDAC2 Modulate TGF-β Signaling during Endothelial-to-Hematopoietic Transition.

HDAC1 HDAC2

6.25e-07228229641990
Pubmed

HDAC1 and HDAC2 restrain the intestinal inflammatory response by regulating intestinal epithelial cell differentiation.

HDAC1 HDAC2

6.25e-07228224040068
Pubmed

Distinct Roles for Intestinal Epithelial Cell-Specific Hdac1 and Hdac2 in the Regulation of Murine Intestinal Homeostasis.

HDAC1 HDAC2

6.25e-07228226174178
Pubmed

Class I histone deacetylase-selective novel synthetic inhibitors potently inhibit human tumor proliferation.

HDAC1 HDAC2

6.25e-07228215297431
Pubmed

[Regulatory effect of ginsenoside Rh2 on HDAC1/2 activity and cyclin in human erythroleukemia K562 cells].

HDAC1 HDAC2

6.25e-07228225270209
Pubmed

Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells.

HDAC1 HDAC2

6.25e-07228224958871
Pubmed

Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma.

HDAC1 HDAC2

6.25e-07228222156779
Pubmed

Histone deacetylase (HDAC) 1 and 2 expression and chemotherapy in gastric cancer.

HDAC1 HDAC2

6.25e-07228220585871
Pubmed

Combined HDAC1 and HDAC2 Depletion Promotes Retinal Ganglion Cell Survival After Injury Through Reduction of p53 Target Gene Expression.

HDAC1 HDAC2

6.25e-07228226129908
Pubmed

Histone deacetylase HDAC1/HDAC2-controlled embryonic development and cell differentiation.

HDAC1 HDAC2

6.25e-07228219412887
Pubmed

A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes.

HDAC1 HDAC2

6.25e-07228219561124
Pubmed

Human pancreatic amylase is encoded by two different genes.

AMY2A AMY2B

6.25e-0722823260028
Pubmed

The human amylase-encoding genes amy2 and amy3 are identical to AMY2A and AMY2B.

AMY2A AMY2B

6.25e-0722822483397
Pubmed

HDAC1 and HDAC2 independently predict mortality in hepatocellular carcinoma by a competing risk regression model in a Southeast Asian population.

HDAC1 HDAC2

6.25e-07228226352599
Pubmed

Leucine zipper domain is required for Kaposi sarcoma-associated herpesvirus (KSHV) K-bZIP protein to interact with histone deacetylase and is important for KSHV replication.

HDAC1 HDAC2

6.25e-07228222416134
Pubmed

Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancer.

HDAC1 HDAC2

6.25e-07228223251689
Pubmed

Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity.

HDAC1 HDAC2

6.25e-07228232934238
Pubmed

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining.

HDAC1 HDAC2

6.25e-07228220802485
Pubmed

Histone deacetylase 1 and 2 in mesenchymal tumors.

HDAC1 HDAC2

6.25e-07228222037263
Pubmed

Loss of histone deacetylase 2 improves working memory and accelerates extinction learning.

HDAC1 HDAC2

6.25e-07228223575838
Pubmed

Inhibition of histone deacetylase 1 (HDAC1) and HDAC2 enhances CRISPR/Cas9 genome editing.

HDAC1 HDAC2

6.25e-07228231799598
Pubmed

Podocyte histone deacetylase activity regulates murine and human glomerular diseases.

HDAC1 HDAC2

6.25e-07228230776024
Pubmed

The binding of histone deacetylases and the integrity of zinc finger-like motifs of the E7 protein are essential for the life cycle of human papillomavirus type 31.

HDAC1 HDAC2

6.25e-07228215016876
Pubmed

Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis.

HDAC1 HDAC2

6.25e-07228221270520
Pubmed

Phosphatase inhibition leads to histone deacetylases 1 and 2 phosphorylation and disruption of corepressor interactions.

HDAC1 HDAC2

6.25e-07228211919195
Pubmed

Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor-induced thrombocytopenia.

HDAC1 HDAC2

6.25e-07228221292776
Pubmed

Genetic dissection of histone deacetylase requirement in tumor cells.

HDAC1 HDAC2

6.25e-07228219416910
Pubmed

Human pancreatic alpha-amylase: phenotypic codominance and new electrophoretic variants.

AMY2A AMY2B

6.25e-072282309725
Pubmed

Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice.

HDAC1 HDAC2

6.25e-07228223287868
Pubmed

HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid Cancer.

HDAC1 HDAC2

6.25e-07228230669676
Pubmed

HDAC1,2 Knock-Out and HDACi Induced Cell Apoptosis in Imatinib-Resistant K562 Cells.

HDAC1 HDAC2

6.25e-07228231071955
Pubmed

JAK-STAT Pathway Inhibition Partially Restores Intestinal Homeostasis in Hdac1- and Hdac2-Intestinal Epithelial Cell-Deficient Mice.

HDAC1 HDAC2

6.25e-07228233498747
Pubmed

Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy.

HDAC1 HDAC2

6.25e-07228221725353
Pubmed

Histone deacetylases 1 and 2 regulate DNA replication and DNA repair: potential targets for genome stability-mechanism-based therapeutics for a subset of cancers.

HDAC1 HDAC2

6.25e-07228225942572
Pubmed

Regulation of osteogenesis in bone marrow-derived mesenchymal stem cells via histone deacetylase 1 and 2 co-cultured with human gingival fibroblasts and periodontal ligament cells.

HDAC1 HDAC2

6.25e-07228236346011
Pubmed

Histone deacetylases 1 and 2 form a developmental switch that controls excitatory synapse maturation and function.

HDAC1 HDAC2

6.25e-07228219553468
Pubmed

A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog.

HDAC1 HDAC2

6.25e-07228224449838
Pubmed

HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells.

HDAC1 HDAC2

6.25e-07228220398369
Pubmed

Loss of histone deacetylases 1 and 2 in hepatocytes impairs murine liver regeneration through Ki67 depletion.

HDAC1 HDAC2

1.87e-06328223744762
Pubmed

Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo.

HDAC1 HDAC2

1.87e-06328230279482
Pubmed

HDAC1/2 and HDAC3 play distinct roles in controlling adult Meibomian gland homeostasis.

HDAC1 HDAC2

1.87e-06328238679196
Pubmed

Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy.

HDAC1 HDAC2

1.87e-06328221367693
Pubmed

Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity.

HDAC1 HDAC2

1.87e-06328218172012
Pubmed

Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis.

HDAC1 HDAC2

1.87e-06328224763403
Pubmed

Acetylation-Dependent Control of Global Poly(A) RNA Degradation by CBP/p300 and HDAC1/2.

HDAC1 HDAC2

1.87e-06328227635759
Pubmed

Mutual Balance of Histone Deacetylases 1 and 2 and the Acetyl Reader ATAD2 Regulates the Level of Acetylation of Histone H4 on Nascent Chromatin of Human Cells.

HDAC1 HDAC2

1.87e-06328232015101
Pubmed

Exercise and diabetes have opposite effects on the assembly and O-GlcNAc modification of the mSin3A/HDAC1/2 complex in the heart.

HDAC1 HDAC2

1.87e-06328223835259
Pubmed

Retinoic acid and histone deacetylases regulate epigenetic changes in embryonic stem cells.

HDAC1 HDAC2

1.87e-06328224821725
Pubmed

The structure of two distinct pancreatic amylase genes in mouse strain YBR.

AMY2A AMY2B

1.87e-0632822413838
Pubmed

Multiple non-allelic genes encoding pancreatic alpha-amylase of mouse are expressed in a strain-specific fashion.

AMY2A AMY2B

1.87e-0632826098446
Pubmed

Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development.

HDAC1 HDAC2

1.87e-06328222223663
Pubmed

Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryos.

HDAC1 HDAC2

1.87e-06328218501342
Pubmed

Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration.

HDAC1 HDAC2

1.87e-06328228139683
Pubmed

PML-RARalpha alleviates the transcriptional repression mediated by tumor suppressor Rb.

HDAC1 HDAC2

1.87e-06328211583987
Pubmed

Protein kinase CK2 regulates the dimerization of histone deacetylase 1 (HDAC1) and HDAC2 during mitosis.

HDAC1 HDAC2

1.87e-06328223612983
Pubmed

Evolution of the amylase multigene family. YBR/Ki mice express a pancreatic amylase gene which is silent in other strains.

AMY2A AMY2B

1.87e-0632822414282
Pubmed

Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3.

HDAC1 HDAC2

1.87e-0632828917507
Pubmed

HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling.

HDAC1 HDAC2

1.87e-06328238254102
Pubmed

Selective impact of MeCP2 and associated histone deacetylases on the dynamics of evoked excitatory neurotransmission.

HDAC1 HDAC2

1.87e-06328221511710
Pubmed

Cell Cycle and Senescence Regulation by Podocyte Histone Deacetylase 1 and 2.

HDAC1 HDAC2

1.87e-06328236414418
Pubmed

Inactivation of HDAC1 or HDAC2 induces gamma globin expression without altering cell cycle or proliferation.

HDAC1 HDAC2

1.87e-06328225808664
Pubmed

Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer.

HDAC1 HDAC2

1.87e-06328219099586
Pubmed

MeCP2 and histone deacetylases 1 and 2 in dorsal striatum collectively suppress repetitive behaviors.

HDAC1 HDAC2

1.87e-06328227668390
Pubmed

A DNMT3A2-HDAC2 Complex Is Essential for Genomic Imprinting and Genome Integrity in Mouse Oocytes.

HDAC1 HDAC2

1.87e-06328226586441
Pubmed

Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy.

HDAC1 HDAC2

1.87e-06328218212746
Pubmed

The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression.

HDAC1 HDAC2

1.87e-06328211564889
Pubmed

Glucocorticoid receptor binding site in the mouse alpha-amylase 2 gene mediates response to the hormone.

AMY2A AMY2B

1.87e-0632828413315
Pubmed

HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130.

HDAC1 HDAC2

1.87e-06328229472538
Pubmed

Differential Effects of Histone Deacetylases on the Expression of NKG2D Ligands and NK Cell-Mediated Anticancer Immunity in Lung Cancer Cells.

HDAC1 HDAC2

1.87e-06328234203519
InteractionNCAPG interactions

FLII ACACA C9orf78 HDAC1 HDAC2

6.50e-06202275int:NCAPG
InteractionSLFN11 interactions

FLII SLFN11 ACACA C9orf78 HDAC1 HDAC2

8.61e-06376276int:SLFN11
InteractionNCAPD2 interactions

FLII ACACA C9orf78 HDAC1 HDAC2

1.33e-05234275int:NCAPD2
InteractionC22orf31 interactions

HDAC1 HDAC2

1.72e-055272int:C22orf31
InteractionSMC4 interactions

FLII ACACA C9orf78 HDAC1 HDAC2

3.19e-05281275int:SMC4
InteractionFLII interactions

FLII SLFN11 C9orf78 HDAC1 HDAC2

4.23e-05298275int:FLII
InteractionEFCAB6 interactions

EFCAB6 HDAC1

4.82e-058272int:EFCAB6
InteractionSNAI3 interactions

HDAC1 HDAC2

4.82e-058272int:SNAI3
InteractionKPNA2 interactions

PMS1 FLII SLFN11 RNMT HDAC1 HDAC2

5.29e-05519276int:KPNA2
InteractionMCCC2 interactions

SLFN11 ACACA C9orf78 HDAC1

6.11e-05162274int:MCCC2
InteractionDNAJA1 interactions

FLII SLFN11 ACACA C9orf78 HDAC1 HDAC2

6.14e-05533276int:DNAJA1
InteractionHFM1 interactions

PMS1 SLFN11

6.19e-059272int:HFM1
InteractionSMC2 interactions

FLII ACACA C9orf78 HDAC1 HDAC2

6.19e-05323275int:SMC2
InteractionAMY2B interactions

AMY2A AMY2B

7.73e-0510272int:AMY2B
InteractionNUP50 interactions

PMS1 SLFN11 ACACA C9orf78 HDAC1

8.00e-05341275int:NUP50
InteractionRFC2 interactions

PMS1 FLII SLFN11 C9orf78

8.07e-05174274int:RFC2
InteractionPPP4R3A interactions

FLII ACACA C9orf78 HDAC1

9.00e-05179274int:PPP4R3A
InteractionRBBP4 interactions

FLII SLFN11 ACACA C9orf78 HDAC1 HDAC2

9.15e-05573276int:RBBP4
InteractionKPNA1 interactions

RNMT PAPSS1 C9orf78 HDAC1 HDAC2

9.17e-05351275int:KPNA1
InteractionPSMD11 interactions

NLRP9 SLFN11 ACACA LRIF1 HDAC1

9.42e-05353275int:PSMD11
InteractionMYH10 interactions

FLII SLFN11 ACACA HDAC1 HDAC2

1.02e-04359275int:MYH10
InteractionMCCC1 interactions

ACACA C9orf78 HDAC1 HDAC2

1.07e-04187274int:MCCC1
InteractionOVOL1 interactions

HDAC1 HDAC2

1.13e-0412272int:OVOL1
InteractionPSMC1 interactions

PMS1 ACACA C9orf78 HDAC1 HDAC2

1.15e-04368275int:PSMC1
InteractionCCDC71 interactions

ACACA HDAC1 HDAC2

1.20e-0472273int:CCDC71
InteractionZNF843 interactions

AMY2A AMY2B

1.56e-0414272int:ZNF843
InteractionIPO5 interactions

PMS1 ASB15 C9orf78 HDAC1 HDAC2

1.99e-04414275int:IPO5
InteractionRFC1 interactions

PMS1 SLFN11 C9orf78 HDAC1

2.40e-04231274int:RFC1
InteractionATF3 interactions

LRIF1 HDAC1 HDAC2

2.65e-0494273int:ATF3
InteractionBRMS1 interactions

LRIF1 HDAC1 HDAC2

2.82e-0496273int:BRMS1
InteractionGRIP1 interactions

FLII FREM2 HDAC1

2.82e-0496273int:GRIP1
InteractionH2BC14 interactions

SLFN11 HDAC1 HDAC2

3.18e-04100273int:H2BC14
InteractionHOXA11 interactions

HDAC1 HDAC2

3.57e-0421272int:HOXA11
InteractionAMY2A interactions

AMY2A AMY2B

3.57e-0421272int:AMY2A
InteractionPPP6R3 interactions

FLII C9orf78 HDAC1 HDAC2

3.65e-04258274int:PPP6R3
InteractionZFPM1 interactions

HDAC1 HDAC2

3.93e-0422272int:ZFPM1
InteractionSPAG9 interactions

FLII ACACA HDAC1 HDAC2

4.22e-04268274int:SPAG9
InteractionMIER3 interactions

HDAC1 HDAC2

4.30e-0423272int:MIER3
InteractionPHF21B interactions

HDAC1 HDAC2

4.30e-0423272int:PHF21B
InteractionMSH6 interactions

PMS1 FLII C9orf78 HDAC1

4.40e-04271274int:MSH6
InteractionRCOR1 interactions

FLII ACACA C9orf78 HDAC1 HDAC2

4.48e-04494275int:RCOR1
InteractionH3C3 interactions

PMS1 LRIF1 C9orf78 HDAC1 HDAC2

4.52e-04495275int:H3C3
InteractionEID2 interactions

HDAC1 HDAC2

4.68e-0424272int:EID2
InteractionGFI1 interactions

HDAC1 HDAC2

4.68e-0424272int:GFI1
InteractionBOC interactions

BOC LRIF1

4.68e-0424272int:BOC
InteractionHDAC1 interactions

FLII SLFN11 ACACA EFCAB6 C9orf78 HDAC1 HDAC2

5.01e-041108277int:HDAC1
InteractionIKZF2 interactions

HDAC1 HDAC2

5.51e-0426272int:IKZF2
InteractionPDX1 interactions

HDAC1 HDAC2

5.51e-0426272int:PDX1
InteractionACTL6A interactions

FLII SLFN11 HDAC1 HDAC2

5.60e-04289274int:ACTL6A
InteractionZFPM2 interactions

HDAC1 HDAC2

6.39e-0428272int:ZFPM2
InteractionH2AJ interactions

HABP4 SLFN11 C9orf78

6.40e-04127273int:H2AJ
InteractionZNF827 interactions

HDAC1 HDAC2

6.86e-0429272int:ZNF827
InteractionKPNB1 interactions

SLFN11 RNMT C9orf78 HDAC1 HDAC2

6.94e-04544275int:KPNB1
InteractionSENP1 interactions

SLFN11 HDAC1 HDAC2

7.00e-04131273int:SENP1
InteractionNONO interactions

PMS1 HABP4 SLFN11 HDAC1 HDAC2

7.24e-04549275int:NONO
InteractionIFT74 interactions

C9orf78 IFT172 HDAC1

7.32e-04133273int:IFT74
InteractionESCO1 interactions

HDAC1 HDAC2

7.35e-0430272int:ESCO1
InteractionGYG2 interactions

SLC25A24 AMY2A

7.35e-0430272int:GYG2
InteractionNCAPH interactions

FLII ACACA HDAC1 HDAC2

7.74e-04315274int:NCAPH
InteractionZMYM3 interactions

TGFB3 HDAC1 HDAC2

7.98e-04137273int:ZMYM3
InteractionEML4 interactions

FLII HDAC1 HDAC2

7.98e-04137273int:EML4
InteractionKDM5C interactions

SLFN11 HDAC1 HDAC2

8.32e-04139273int:KDM5C
InteractionHDAC2 interactions

FLII SLFN11 PAPSS1 C9orf78 HDAC1 HDAC2

8.38e-04865276int:HDAC2
InteractionPPP1R12A interactions

FLII C9orf78 ERLEC1 HDAC2

8.40e-04322274int:PPP1R12A
InteractionNUP88 interactions

SLFN11 C9orf78 HDAC1

8.49e-04140273int:NUP88
InteractionDENND4C interactions

MELK HDAC1 HDAC2

8.49e-04140273int:DENND4C
InteractionSAP30L interactions

HDAC1 HDAC2

8.90e-0433272int:SAP30L
InteractionDCTN4 interactions

ACACA HDAC1 HDAC2

9.03e-04143273int:DCTN4
InteractionDNAJC13 interactions

LRIF1 HDAC1 HDAC2

9.03e-04143273int:DNAJC13
InteractionDELEC1 interactions

HDAC1 HDAC2

9.44e-0434272int:DELEC1
InteractionTNFSF10 interactions

HDAC1 HDAC2

1.00e-0335272int:TNFSF10
InteractionTGIF2LX interactions

HDAC1 HDAC2

1.06e-0336272int:TGIF2LX
InteractionRAB3GAP2 interactions

ACACA C9orf78 HDAC1

1.08e-03152273int:RAB3GAP2
InteractionLRRFIP1 interactions

FLII HDAC1 HDAC2

1.10e-03153273int:LRRFIP1
InteractionCCDC174 interactions

FLII HDAC2

1.12e-0337272int:CCDC174
InteractionMAFK interactions

HDAC1 HDAC2

1.12e-0337272int:MAFK
InteractionAKR1C3 interactions

HABP4 LRIF1

1.12e-0337272int:AKR1C3
InteractionMIER2 interactions

HDAC1 HDAC2

1.12e-0337272int:MIER2
InteractionPADI4 interactions

HDAC1 HDAC2

1.12e-0337272int:PADI4
InteractionBAZ1A interactions

C9orf78 HDAC1 HDAC2

1.16e-03156273int:BAZ1A
InteractionCPVL interactions

C9orf78 ERLEC1 HDAC2

1.16e-03156273int:CPVL
InteractionNR2E1 interactions

HDAC1 HDAC2

1.18e-0338272int:NR2E1
InteractionSMARCC2 interactions

FLII SLFN11 HDAC1 HDAC2

1.18e-03353274int:SMARCC2
InteractionPRMT1 interactions

FLII HABP4 RNMT LRIF1 HDAC1 HDAC2

1.21e-03929276int:PRMT1
InteractionKAT5 interactions

FLII HABP4 LRIF1 HDAC1

1.24e-03358274int:KAT5
InteractionC9orf78 interactions

FLII SLFN11 C9orf78 HDAC1 HDAC2

1.25e-03620275int:C9orf78
InteractionMBD2 interactions

C9orf78 HDAC1 HDAC2

1.27e-03161273int:MBD2
InteractionTMOD1 interactions

FLII HABP4 ERLEC1

1.27e-03161273int:TMOD1
InteractionPOLR3A interactions

HABP4 HDAC1 HDAC2

1.32e-03163273int:POLR3A
InteractionALDH1A2 interactions

BOC ERLEC1

1.37e-0341272int:ALDH1A2
InteractionTGIF1 interactions

LRIF1 HDAC1

1.37e-0341272int:TGIF1
InteractionPPM1E interactions

SLFN11 HDAC1

1.37e-0341272int:PPM1E
InteractionZNF521 interactions

HDAC1 HDAC2

1.37e-0341272int:ZNF521
InteractionMBD3L2 interactions

HDAC1 HDAC2

1.37e-0341272int:MBD3L2
InteractionPARP1 interactions

FLII SLFN11 PAPSS1 LRIF1 C9orf78 HDAC1 HDAC2

1.39e-031316277int:PARP1
InteractionSNRNP40 interactions

PMS1 SLFN11 ACACA C9orf78 HDAC2

1.41e-03637275int:SNRNP40
InteractionMORF4L2 interactions

HABP4 HDAC1 HDAC2

1.44e-03168273int:MORF4L2
InteractionIFRD1 interactions

HDAC1 HDAC2

1.44e-0342272int:IFRD1
InteractionJDP2 interactions

HDAC1 HDAC2

1.44e-0342272int:JDP2
InteractionRBP1 interactions

HDAC1 HDAC2

1.44e-0342272int:RBP1
Cytoband1p21

AMY2A AMY2B

9.82e-05242821p21
Cytoband1p13.3

SLC25A24 LRIF1

8.21e-04692821p13.3
CytobandEnsembl 112 genes in cytogenetic band chr1p21

AMY2A AMY2B

1.96e-03107282chr1p21
CytobandEnsembl 112 genes in cytogenetic band chr17q12

SLFN11 ACACA

3.74e-03149282chr17q12
CytobandEnsembl 112 genes in cytogenetic band chr1p13

SLC25A24 LRIF1

7.35e-03211282chr1p13
GeneFamilyHistone deacetylases, class I|EMSY complex|NuRD complex|SIN3 histone deacetylase complex

HDAC1 HDAC2

4.99e-064172989
GeneFamilyHistone deacetylases, class I|EMSY complex|NuRD complex|SIN3 histone deacetylase complex

HDAC1 HDAC2

2.98e-0591721306
GeneFamilyPHD finger proteins|NuRD complex

HDAC1 HDAC2

5.46e-05121721305
GeneFamilyHistone deacetylases, class I|EMSY complex|NuRD complex|SIN3 histone deacetylase complex

HDAC1 HDAC2

5.46e-05121721243
GeneFamilyFibronectin type III domain containing

BOC PTPRJ

9.70e-03160172555
GeneFamilyEF-hand domain containing

SLC25A24 EFCAB6

1.76e-02219172863
CoexpressionGSE40274_CTRL_VS_FOXP3_AND_PBX1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN

TGFB3 ACACA MELK SYT14

2.69e-05164284M9106
CoexpressionGSE17721_0.5H_VS_8H_GARDIQUIMOD_BMDC_DN

BOC PAPSS1 HDAC1 HDAC2

5.72e-05199284M4142
CoexpressionBERGER_MBD2_TARGETS

AMY2A AMY2B

6.02e-0511282MM905
CoexpressionCAIRO_HEPATOBLASTOMA_UP

PMS1 ACACA PAPSS1 HDAC2

7.45e-05213284M14601
DrugAC1L1EA5

BOC ACACA HDAC1 HDAC2

1.91e-0824284CID000002706
Drugallylsilane

BOC ACACA

8.74e-064282CID000140349
DrugVorinostat

HDAC1 HDAC2

1.46e-055282DB02546
DrugS-p-nitrobenzyloxycarbonylglutathione

AMY2A AMY2B ACACA

1.48e-0539283CID004632704
Drugammonium sulfate

BOC AMY2A AMY2B ACACA

1.65e-05126284CID000024538
Drug4,6-O-3-ketobutylidene maltopentaose

AMY2A AMY2B

2.18e-056282CID003083414
DrugCNP-G3

AMY2A AMY2B

2.18e-056282CID003082910
DrugR 623

AMY2A AMY2B

2.18e-056282CID003027594
Drugdimethylaminomethylferrocene

AMY2A AMY2B

2.18e-056282CID000102082
Drugmono-6-deoxy-6-fluorocyclomaltoheptaose

AMY2A AMY2B

2.18e-056282CID000127364
Drugkasugamycin

FLII AMY2A AMY2B

2.60e-0547283CID000065174
DrugBG5P

AMY2A AMY2B

3.05e-057282CID003082752
DrugAC1L5BOU

AMY2A AMY2B

3.05e-057282CID000174858
Drug6-O-methylglucose

AMY2A ACACA

3.05e-057282CID000151009
DrugAlfadexum

AMY2A AMY2B ACACA

3.96e-0554283CID000024796
Drugdesethylaprophen

AMY2A AMY2B

4.07e-058282CID000163919
Drugazintamide

AMY2A AMY2B

4.07e-058282CID000071105
DrugDB08184

PMS1 PTPRJ HDAC1 HDAC2

4.98e-05167284CID009547945
Drugginsenoside Rh2

HDAC1 HDAC2

5.22e-059282ctd:C055305
Drugalpha-maltosyl fluoride

AMY2A AMY2B

5.22e-059282CID000194237
Drugtrestatin A

AMY2A AMY2B

5.22e-059282CID003054994
DrugAC1LAC07

AMY2A AMY2B

6.52e-0510282CID000485275
DrugAC1L3M0Q

AMY2A AMY2B

6.52e-0510282CID000118008
Drugacetylhypofluorite

BOC AMY2A

6.52e-0510282CID000127602
DrugGlc)4

AMY2A AMY2B

6.52e-0510282CID000189098
DrugCI-994

HDAC1 HDAC2

6.52e-0510282CID000002746
DrugRo 20-0083

AMY2A AMY2B

6.52e-0510282CID003082332
Drugvalidamycin D

AMY2A AMY2B

7.97e-0511282CID000166726
DrugN-methylpyrrole

BOC ACACA

7.97e-0511282CID000007304
DrugHgI2

AMY2A AMY2B

7.97e-0511282CID000024485
Drug2C KM

AMY2A AMY2B

7.97e-0511282CID009549196
DrugFG5P

AMY2A AMY2B

7.97e-0511282CID000127486
DrugCNP-G5

AMY2A AMY2B

7.97e-0511282CID000127309
Drugazaprophen

AMY2A AMY2B

9.55e-0512282CID000129486
Drug1-adamantaneacetic acid

BOC ACACA

9.55e-0512282CID000123221
Drugmethyl 1'-epiacarviosin

AMY2A AMY2B

1.13e-0413282CID000197426
Drugisoacarbose

AMY2A AMY2B

1.13e-0413282CID000449165
Drug8a-c

BOC AMY2A

1.13e-0413282CID000066085
Drugsodium methoxide

BOC AMY2A

1.32e-0414282CID010942334
DrugCyclodextrins

AMY2A AMY2B

1.32e-0414282CID000024238
Drugterephthaloyl chloride

AMY2A AMY2B

1.32e-0414282CID000007488
Drug2-chloro-4-nitrophenol

AMY2A AMY2B

1.32e-0414282CID000012074
Drug2-[(1R,2R,3S,4R,5R,6S)-2-[(2R,5S)-3-[(3S,4S,5R,6S)-4,5-dihydroxy-3-(methylamino)-6-methylol-tetrahydropyran-2-yl]-4-formyl-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]oxy-5-guanidino-3,4,6-trihydroxy-cyclohexyl]guanidine

BOC AMY2A AMY2B

1.43e-0483283CID011968896
Drugbutyl methacrylate

BOC IFT172

1.52e-0415282CID000007354
Drugnafadotride

ACACA HDAC2

1.52e-0415282CID003408722
Drug4-nitrophenylmaltoheptaoside

AMY2A AMY2B

1.52e-0415282CID000173254
Drugformamide

BOC FMO4 RNMT

1.54e-0485283CID000000713
DrugAC1NV99J

HDAC1 HDAC2

1.73e-0416282CID005474719
Druggamma-cyclodextrin

AMY2A AMY2B

1.73e-0416282CID000086575
DrugBay e 4609

AMY2A AMY2B

1.73e-0416282CID003085308
Drugpolyphenon E

HDAC1 HDAC2

1.96e-0417282ctd:C472086
DrugRodeo

HDAC1 HDAC2

1.96e-0417282CID000038078
Drugtrimitan

AMY2A AMY2B

2.20e-0418282CID000005561
DrugAC1L1EXH

HDAC1 HDAC2

2.20e-0418282CID000002992
Drugaprophen

AMY2A AMY2B

2.20e-0418282CID000071128
DrugLugol's iodine

AMY2A ACACA

2.46e-0419282CID000105053
DrugNSC3852

HDAC1 HDAC2

2.73e-0420282CID000019103
DrugAC1L3XPY

AMY2A AMY2B

3.02e-0421282CID000124005
Drug1,8-diazabicycloundec-7-ene

BOC ACACA

3.32e-0422282CID000081184
DrugNSC-1905

BOC ACACA

3.32e-0422282CID003816245
DrugAC1L1QCE

BOC ACACA

3.32e-0422282CID000008135
Drugmaltosaccharide

AMY2A AMY2B

3.32e-0422282CID005461034
DrugPanose B

AMY2A AMY2B

3.96e-0424282CID000439297
DrugCID439354

AMY2A AMY2B

4.30e-0425282CID000439354
DrugUF010 compound

HDAC1 HDAC2

4.30e-0425282ctd:C000602704
DrugNSC24559

TGFB3 HDAC1 HDAC2

4.46e-04122283CID000029051
Drughydroxycitrate

AMY2A ACACA

4.65e-0426282CID000123908
Drugcupric oxide

PMS1 RNMT MELK HDAC1 ZNF222

4.73e-04543285ctd:C030973
Drugy BT

ACACA HDAC2

5.02e-0427282CID000447121
Drugdl-cystine

BOC RGS7 IFT172

5.13e-04128283CID000000595
Drugdecanoate

BOC AMY2A ACACA

5.49e-04131283CID000002969
Drugtrimethylphosphine

BOC ACACA

6.21e-0430282CID000068983
DrugN,N'-disalicylidene-1,3-diaminopropane

AMY2A AMY2B

6.21e-0430282CID005373003
Drugdinoseb

AMY2A IFT172

6.21e-0430282CID000006950
Drugbeta-propiolactone

BOC ACACA

7.07e-0432282CID000002365
DrugFolin Marenzi reagent

AMY2A AMY2B

7.07e-0432282CID000452313
DrugAC1L1G8B

HDAC1 HDAC2

7.07e-0432282CID000003571
Drugacetate

BOC AMY2A AMY2B ACACA HDAC1

7.38e-04599285CID000000175
DrugR625

AMY2A AMY2B

7.52e-0433282CID000072375
Drugp-nitrophenyl

BOC AMY2A AMY2B

7.52e-04146283CID000007416
DrugMS-275

FLII HDAC1 HDAC2

7.98e-04149283CID000004261
Drughexafluorophosphate

BOC AMY2A

7.99e-0434282CID000009886
Drugnorspermine

BOC ACACA

7.99e-0434282CID000078350
DrugRhodium

BOC ACACA

7.99e-0434282CID000023948
DrugPNPC

AMY2A AMY2B

8.46e-0435282CID000165125
DrugAC1OAH4D

HDAC1 HDAC2

8.95e-0436282CID006857719
DrugBCDs

AMY2A AMY2B

9.46e-0437282CID000364214
DrugL-365,260

BOC FLII

9.46e-0437282CID000104929
Drugmaltohexaose

AMY2A AMY2B

1.05e-0339282CID000439606
Drug7-OH-DPAT

ACACA HDAC2

1.05e-0339282CID000001219
Drugmaltoheptose

AMY2A AMY2B

1.11e-0340282CID003037125
DrugFR 4

BOC ACACA

1.11e-0340282CID005288243
Drugcompound 21

BOC ACACA

1.11e-0340282CID005312128
DrugHFIP

BOC AMY2A

1.11e-0340282CID000013529
Diseasealpha-amylase 1 measurement

AMY2A AMY2B

2.89e-059272EFO_0801371
Diseasealopecia areata (is_marker_for)

HDAC1 HDAC2

3.61e-0510272DOID:986 (is_marker_for)
DiseaseHereditary non-polyposis colorectal cancer syndrome

PMS1 PTPRJ

2.79e-0427272C1112155
DiseaseHereditary Nonpolyposis Colorectal Cancer

PMS1 PTPRJ

3.22e-0429272C1333990
Diseaseacute lymphoblastic leukemia (is_marker_for)

HDAC1 HDAC2

4.44e-0434272DOID:9952 (is_marker_for)
Diseasecervix uteri carcinoma in situ (is_marker_for)

HDAC1 HDAC2

6.79e-0442272DOID:8991 (is_marker_for)
DiseaseGastrointestinal Stromal Sarcoma

BOC IFT172

8.50e-0447272C3179349
DiseaseGastrointestinal Stromal Tumors

BOC IFT172

9.61e-0450272C0238198
Diseasepulmonary hypertension (is_marker_for)

HDAC1 HDAC2

1.57e-0364272DOID:6432 (is_marker_for)
Diseasetype 1 diabetes mellitus (is_marker_for)

HDAC1 HDAC2

1.98e-0372272DOID:9744 (is_marker_for)
Diseasealcohol use disorder measurement, alcohol consumption measurement

PTPRJ SYT14

3.56e-0397272EFO_0007878, EFO_0009458
Diseasepneumonia, COVID-19

ACACA MELK

4.79e-03113272EFO_0003106, MONDO_0100096
DiseasePolydactyly

FREM2 IFT172

5.13e-03117272C0152427
DiseaseSquamous cell carcinoma

HDAC1 HDAC2

5.74e-03124272C0007137

Protein segments in the cluster

PeptideGeneStartEntry
YKEDNYVIMTTAHKE

ERLEC1

61

Q96DZ1
EYVKYKYAMDEADEK

ASB15

61

Q8WXK1
DLKANAEYIKMADHY

ACACA

161

Q13085
EKDYVRSKIAEYMNH

AMY2B

186

P19961
MKDYDELLKYYELHE

MELK

1

Q14680
EKDYVRSKIAEYMNH

AMY2A

186

P04746
ASEYKYVVKHKMENE

PTPRJ

146

Q12913
QKPYDDDAEYMKHTR

FLII

1151

Q13045
KRTEMEYYTHEKQEK

LRIF1

691

Q5T3J3
AEEMTKYHSDDYIKF

HDAC1

61

Q13547
KIYYIHTADDEVKMD

FREM2

1491

Q5SZK8
HKSKYRDDMVKDDYE

HABP4

326

Q5JVS0
KDTSKDKFDYIAYMD

FMO4

421

P31512
DLAITMYKKHKLYDD

IFT172

1001

Q9UG01
NKKKKRMDYYDSEHH

PAPSS1

566

O43252
SDYKKDMVEGDKYWH

BOC

761

Q9BWV1
MKLRDEEYEKFSKHY

EFCAB6

206

Q5THR3
SEKVDDYEHAAKYMK

RNMT

431

O43148
TAEEMTKYHSDEYIK

HDAC2

61

Q92769
MKYYTSKINSHEDLE

PMS1

71

P54277
DAQEHIYKLMKSDSY

RGS7

421

P49802
SQDKIYNSYMDKDEH

SYT14

71

Q8NB59
AKEVEHYKYELLKAM

SLFN11

816

Q7Z7L1
KDKEMYHDYICQYKE

SIX6OS1

106

Q8N1H7
EHFYKETMKNEYKEL

NLRP9

121

Q7RTR0
EKATDDYHYEKFKKM

C9orf78

271

Q9NZ63
DFEEFMKYLKDHEKK

SLC25A24

76

Q6NUK1
TESEYYAKEIHKFDM

TGFB3

96

P10600
CMVHTAEKLYKSEKY

ZNF222

276

Q9UK12