Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionreceptor signaling protein tyrosine kinase activator activity

ALK LTK

4.56e-065142GO:0030298
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

TYK2 ALK LTK

1.29e-04145143GO:0004713
GeneOntologyMolecularFunctionprotein tyrosine kinase activator activity

ALK LTK

2.84e-0436142GO:0030296
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

ALK LTK

9.26e-0465142GO:0004714
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

ALK LTK

1.58e-0385142GO:0019199
GeneOntologyMolecularFunctionprotein kinase activator activity

ALK LTK

4.75e-03149142GO:0030295
GeneOntologyMolecularFunctionkinase activator activity

ALK LTK

5.38e-03159142GO:0019209
GeneOntologyMolecularFunctionprotein kinase activity

TYK2 ALK LTK

7.67e-03600143GO:0004672
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

PLCD4 HPS1

1.11e-02231142GO:0005085
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

TYK2 ALK LTK

1.21e-02709143GO:0016773
GeneOntologyMolecularFunctionprotein kinase regulator activity

ALK LTK

1.38e-02259142GO:0019887
GeneOntologyMolecularFunctioncalcium ion binding

PLCD4 EPDR1 ADGRE1

1.40e-02749143GO:0005509
GeneOntologyMolecularFunctionenzyme regulator activity

PLCD4 ALK HPS1 LTK

1.42e-021418144GO:0030234
GeneOntologyMolecularFunctionkinase activity

TYK2 ALK LTK

1.48e-02764143GO:0016301
GeneOntologyMolecularFunctionglycosyltransferase activity

GBA2 ZC3HAV1

1.68e-02288142GO:0016757
GeneOntologyMolecularFunctionkinase regulator activity

ALK LTK

1.87e-02305142GO:0019207
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

TYK2 ALK LTK

2.55e-02938143GO:0016772
GeneOntologyBiologicalProcesspeptidyl-tyrosine autophosphorylation

ALK LTK

8.41e-0522132GO:0038083
GeneOntologyCellularComponentreceptor complex

TYK2 ALK AHRR LTK

4.73e-04581144GO:0043235
DomainTyr_kinase_rcpt_2_CS

ALK LTK

2.86e-0511142IPR002011
DomainRECEPTOR_TYR_KIN_II

ALK LTK

3.43e-0512142PS00239
DomainTyrKc

TYK2 ALK LTK

3.54e-0588143SM00219
DomainTyr_kinase_cat_dom

TYK2 ALK LTK

3.54e-0588143IPR020635
DomainPROTEIN_KINASE_TYR

TYK2 ALK LTK

4.74e-0597143PS00109
DomainTyr_kinase_AS

TYK2 ALK LTK

4.74e-0597143IPR008266
DomainPkinase_Tyr

TYK2 ALK LTK

1.11e-04129143PF07714
DomainSer-Thr/Tyr_kinase_cat_dom

TYK2 ALK LTK

1.35e-04138143IPR001245
DomainProtein_kinase_ATP_BS

TYK2 ALK LTK

2.56e-03379143IPR017441
DomainPROTEIN_KINASE_ATP

TYK2 ALK LTK

4.39e-03459143PS00107
DomainProt_kinase_dom

TYK2 ALK LTK

5.24e-03489143IPR000719
DomainPROTEIN_KINASE_DOM

TYK2 ALK LTK

5.36e-03493143PS50011
DomainKinase-like_dom

TYK2 ALK LTK

6.97e-03542143IPR011009
DomainEGF

MUC4 ADGRE1

1.30e-02235142SM00181
DomainEGF_3

MUC4 ADGRE1

1.30e-02235142PS50026
DomainEGF-like_dom

MUC4 ADGRE1

1.45e-02249142IPR000742
DomainEGF_1

MUC4 ADGRE1

1.52e-02255142PS00022
DomainEGF-like_CS

MUC4 ADGRE1

1.58e-02261142IPR013032
DomainEGF_2

MUC4 ADGRE1

1.63e-02265142PS01186
PathwayREACTOME_SIGNALING_BY_ALK_IN_CANCER

TYK2 ALK

1.87e-0393102M42521
PathwayREACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS

TYK2 ALK ZC3HAV1

3.58e-03464103M27547
Pubmed

Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis.

ALK LTK

1.50e-07214222079349
Pubmed

Identification and chromosomal mapping of new human tyrosine kinase genes.

TYK2 LTK

4.51e-0731422156206
Pubmed

Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α).

ALK LTK

4.51e-07314230061385
Pubmed

Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.

ALK LTK

9.02e-07414226630010
Pubmed

Structural basis of cytokine-mediated activation of ALK family receptors.

ALK LTK

9.02e-07414234646012
Pubmed

FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase.

ALK LTK

9.02e-07414226418745
Pubmed

Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.

ALK LTK

3.16e-06714219815557
Pubmed

LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity.

ALK LTK

6.76e-061014237291945
Pubmed

Identification of APBB1 as a substrate for anaplastic lymphoma kinase.

ALK ZC3HAV1

1.41e-044414239115278
GeneFamilyReceptor Tyrosine Kinases|CD molecules

ALK LTK

2.59e-0440112321
CoexpressionGSE26030_TH1_VS_TH17_DAY15_POST_POLARIZATION_UP

PGGT1B ZC3HAV1 SLC35F5 ADGRE1

3.04e-06199144M8562
CoexpressionGSE3920_UNTREATED_VS_IFNA_TREATED_FIBROBLAST_DN

TYK2 PLCD4 SLC35F5

1.50e-04200143M6687
CoexpressionGSE2585_CD80_HIGH_VS_LOW_AIRE_KO_MTEC_UP

PLCD4 AHRR ADGRE1

1.50e-04200143M6269
CoexpressionGSE11961_MARGINAL_ZONE_BCELL_VS_GERMINAL_CENTER_BCELL_DAY7_DN

TYK2 PGGT1B SLC35F5

1.50e-04200143M9321
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D175|Adult / Lineage, Cell type, age group and donor

MUC4 AHRR EPDR1

1.24e-05148143012845b10850bbc67814da247ee5a69f6d631eaa
ToppCellfacs-Lung-EPCAM-18m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TYK2 AHRR LTK

1.94e-051721437c085c02b59e24e2a2cd393b5e692f9fb19257fe
ToppCellfacs-Lung-EPCAM-18m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TYK2 AHRR LTK

1.94e-05172143c5caae0b21e35a2d5dcd898fbfa1ef33f92c019f
Diseaseneuroblastoma (implicated_via_orthology)

ALK LTK

2.09e-065142DOID:769 (implicated_via_orthology)
Diseasecomparative body size at age 10, self-reported

PLCD4 ALK ZC3HAV1

9.27e-04420143EFO_0009819
DiseasePapillary Renal Cell Carcinoma

MUC4 ALK

1.64e-03128142C1306837
DiseaseRenal Cell Carcinoma

MUC4 ALK

1.64e-03128142C0007134
DiseaseSarcomatoid Renal Cell Carcinoma

MUC4 ALK

1.64e-03128142C1266043
DiseaseChromophobe Renal Cell Carcinoma

MUC4 ALK

1.64e-03128142C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

MUC4 ALK

1.64e-03128142C1266044
Diseaseprimary biliary cirrhosis

TYK2 ZC3HAV1

1.77e-03133142EFO_1001486
Diseaseattention function measurement

CSMD2 ALK

2.19e-03148142EFO_0007636
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

MUC4 ALK

2.19e-03148142C0279702
DiseaseMental Depression

CSMD2 ALK

6.27e-03254142C0011570
Diseasecancer (implicated_via_orthology)

ALK LTK

6.96e-03268142DOID:162 (implicated_via_orthology)
DiseaseDepressive disorder

CSMD2 ALK

8.05e-03289142C0011581

Protein segments in the cluster

PeptideGeneStartEntry
FCRQLHWAMDPPQVV

AHRR

171

A9YTQ3
PCQAPQQWEGRQVMY

EPDR1

41

Q9UM22
HISCMPGTVRRWNYP

CSMD2

1946

Q7Z408
PIQHWMVISEFQYRP

MUC4

5226

Q99102
PVYRIMTQCWQHEPE

LTK

751

P29376
CRWQLNPGMYQHRTV

GBA2

171

Q9HCG7
PHTMYCLPLWQGINL

HPS1

366

Q92902
WCIMRQQNGYHGRPN

PGGT1B

251

P53609
LCHYNNWDPVMVGIR

SLC35F5

471

Q8WV83
PWTCMQQGYRHIHLL

PLCD4

721

Q9BRC7
GPVYRIMTQCWQHQP

ALK

1356

Q9UM73
VQPQGYGMHNRCWLN

ADGRE1

731

Q14246
VPQWYVQQMKRGPDH

ZC3HAV1

686

Q7Z2W4
NWHGMNPREPAVYRC

TYK2

111

P29597