Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	VCX/VCY1	VCX3A VCX3B VCX	9.04e-07	5	85	3	IPR026653
Domain	VCX_VCY	VCX3A VCX3B VCX	9.04e-07	5	85	3	PF15231
Domain	Cullin_CS	CUL2 CUL1	4.24e-04	7	85	2	IPR016157
Domain	CULLIN	CUL2 CUL1	4.24e-04	7	85	2	SM00182
Domain	Cullin_Nedd8	CUL2 CUL1	5.63e-04	8	85	2	PF10557
Domain	Cullin_Nedd8	CUL2 CUL1	5.63e-04	8	85	2	SM00884
Domain	Cullin_neddylation_domain	CUL2 CUL1	5.63e-04	8	85	2	IPR019559
Domain	Cullin_homology	CUL2 CUL1	7.22e-04	9	85	2	IPR016158
Domain	Cullin	CUL2 CUL1	9.00e-04	10	85	2	PF00888
Domain	CULLIN_2	CUL2 CUL1	9.00e-04	10	85	2	PS50069
Domain	Cullin_N	CUL2 CUL1	9.00e-04	10	85	2	IPR001373
Domain	CULLIN_1	CUL2 CUL1	9.00e-04	10	85	2	PS01256
Domain	Cullin_repeat-like_dom	CUL2 CUL1	1.31e-03	12	85	2	IPR016159
Domain	Clathrin/coatomer_adapt-like_N	COPG1 AP3D1	2.07e-03	15	85	2	IPR002553
Domain	Adaptin_N	COPG1 AP3D1	2.07e-03	15	85	2	PF01602
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CUL1 RIF1 MAP1B PNN COPG1 UBE4B MATR3 MDC1 ACIN1 MCM6 DDX20 PRR14L CDC27 HSPA4 GRSF1 AP3D1 HSP90AA1 SON	8.22e-09	1353	89	18	29467282
Pubmed	A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation.	VCX3A VCX3B VCX	6.47e-08	4	89	3	10903929
Pubmed	Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.	RIF1 MAP1B PNN XPO6 ACIN1 HSPA4 AP3D1 EPB41L1	4.88e-07	270	89	8	24366813
Pubmed	SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation.	CUL1 COPG1 MATR3 ACIN1 HSP90AA1	6.63e-07	64	89	5	26511642
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	CUL1 RIF1 PNN COPG1 APPL1 MCM6 DDX20 HSPA4 AP3D1 HSP90AA1 SON	7.27e-07	638	89	11	33239621
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	CUL2 CUL1 DCAF6 SLK TRMT6 EHBP1L1 COPG1 UBE4B P3H1 APPL1 MCM6 SUMO3 HSPA4 AP3D1 EPB41L1 HSP90AA1	8.00e-07	1455	89	16	22863883
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	RIF1 MAP1B PNN COPG1 SYNE2 MDC1 ACIN1 MCM6 DDX20 HSPA4 SON	9.12e-07	653	89	11	22586326
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	CUL1 TRMT6 RASA1 MAP1B COPG1 MCM6 HSPA4 GRSF1 AP3D1 HSP90AA1	1.43e-06	547	89	10	37267103
Pubmed	Proteomic analysis of p16ink4a-binding proteins.	UBE4B MCM6 HSPA4 HSP90AA1	1.55e-06	33	89	4	17955473
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	CUL2 CUL1 USP13 RIF1 PNN ATAD5 MATR3 MDC1 ACIN1 MCM6 SUMO3 HSP90AA1 SON	1.85e-06	1014	89	13	32416067
Pubmed	Discovery of multiple interacting partners of gankyrin, a proteasomal chaperone and an oncoprotein--evidence for a common hot spot site at the interface and its functional relevance.	HSPA4 GRSF1 HSP90AA1	1.92e-06	10	89	3	24338975
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	CUL2 CUL1 COPG1 P3H1 MATR3 MCM6 ZNF236 HSPA4 HSP90AA1	2.43e-06	451	89	9	36168627
Pubmed	Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase.	RIF1 MAP1B MATR3 SUMO3	3.08e-06	39	89	4	25944111
Pubmed	Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II.	CUL2 CUL1 PNN MATR3 MDC1 HSPA4 SON	3.24e-06	244	89	7	30349055
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	CUL2 CUL1 RIF1 PNN MATR3 ACIN1 DDX20	3.24e-06	244	89	7	29884807
Pubmed	Characterization of the Cullin7 E3 ubiquitin ligase--heterodimerization of cullin substrate receptors as a novel mechanism to regulate cullin E3 ligase activity.	CUL1 HSPA4 HSP90AA1	3.50e-06	12	89	3	21946088
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	LPIN1 SLK EHBP1L1 PNN MATR3 ACIN1 HSPA4 HSP90AA1	4.15e-06	360	89	8	33111431
Pubmed	Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones.	UBE4B HSPA4 HSP90AA1	4.55e-06	13	89	3	15189447
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	RIF1 PNN UBE4B XPO6 MATR3 MDC1 ACIN1 APPL1 DDX20 ZFX SON	4.67e-06	774	89	11	15302935
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	RIF1 SLK MAP1B PNN ATAD5 MATR3 ACIN1 PRR14L HSPA4 AP3D1 HSP90AA1 SON	4.67e-06	934	89	12	33916271
Pubmed	Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.	CUL2 CUL1 DCAF6 MAP1B COPG1 MCM6 SUMO3 HSPA4 HSP90AA1	5.17e-06	495	89	9	28581483
Pubmed	The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila.	MAP1B HSPA4 HSP90AA1	5.78e-06	14	89	3	21151955
Pubmed	Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation.	HSPA4 HSP90AA1	6.48e-06	2	89	2	26565746
Pubmed	A dual role for HSP90 and HSP70 in the inflammatory myopathies: from muscle fiber protection to active invasion by macrophages.	HSPA4 HSP90AA1	6.48e-06	2	89	2	19758187
Pubmed	Physical and functional interaction of NCX1 and EAAC1 transporters leading to glutamate-enhanced ATP production in brain mitochondria.	SLC8A1 SLC1A1	6.48e-06	2	89	2	22479505
Pubmed	Modulation of neuritogenesis by a protein implicated in X-linked mental retardation.	VCX3A VCX3B	6.48e-06	2	89	2	19812318
Pubmed	Patient-Derived Pancreatic Cancer Cells Induce C2C12 Myotube Atrophy by Releasing Hsp70 and Hsp90.	HSPA4 HSP90AA1	6.48e-06	2	89	2	36078164
Pubmed	NCX1 and EAAC1 transporters are involved in the protective action of glutamate in an in vitro Alzheimer's disease-like model.	SLC8A1 SLC1A1	6.48e-06	2	89	2	32827867
Pubmed	Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome.	HSPA4 HSP90AA1	6.48e-06	2	89	2	23359685
Pubmed	[In vitro study of expression and effects of HSP70/HSP90 in nasopharyngeal carcinoma cells after thermotherapy].	HSPA4 HSP90AA1	6.48e-06	2	89	2	19764559
Pubmed	Cloning and analysis of a human 86-kDa heat-shock-protein-encoding gene.	HSP90AA1 HSP90AA2P	6.48e-06	2	89	2	2591742
Pubmed	Combined inhibition of heat shock proteins 90 and 70 leads to simultaneous degradation of the oncogenic signaling proteins involved in muscle invasive bladder cancer.	HSPA4 HSP90AA1	6.48e-06	2	89	2	26556859
Pubmed	Gateways for Glutamate Neuroprotection in Parkinson's Disease (PD): Essential Role of EAAT3 and NCX1 Revealed in an In Vitro Model of PD.	SLC8A1 SLC1A1	6.48e-06	2	89	2	32899900
Pubmed	[Association between expressions of HSP70, HSP90 and efficacy of chemotherapy in colorectal cancer patients with unresectable liver metastasis].	HSPA4 HSP90AA1	6.48e-06	2	89	2	19598015
Pubmed	Dual targeting of heat shock proteins 90 and 70 promotes cell death and enhances the anticancer effect of chemotherapeutic agents in bladder cancer.	HSPA4 HSP90AA1	6.48e-06	2	89	2	24718854
Pubmed	The Prognostic Significance of Hsp70/Hsp90 Expression in Breast Cancer: A Systematic Review and Meta-analysis.	HSPA4 HSP90AA1	6.48e-06	2	89	2	29491085
Pubmed	Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis.	VCX3B VCX	6.48e-06	2	89	2	12862317
Pubmed	Mechanism of JNK signal regulation by placental HSP70 and HSP90 in endothelial cell during preeclampsia.	HSPA4 HSP90AA1	6.48e-06	2	89	2	22409343
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	MAP1B PNN MATR3 MDC1 ACIN1 APPL1 MCM6 SON	8.79e-06	399	89	8	35987950
Pubmed	CAND1 enhances deneddylation of CUL1 by COP9 signalosome.	CUL2 CUL1 HSP90AA1	8.86e-06	16	89	3	16036220
Pubmed	The functional interactome landscape of the human histone deacetylase family.	RIF1 PNN SYNE2 ACIN1 APPL1 DDX20 SON	9.80e-06	289	89	7	23752268
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	RIF1 SLK PNN COPG1 MATR3 SYNE2 MDC1 MCM6 DDX20 HSPA4 GRSF1 AP3D1 HSP90AA1 SON	1.40e-05	1415	89	14	28515276
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	SLC38A1 CUL1 RIF1 SLK TRMT6 PNN COPG1 MATR3 MDC1 ACIN1 MCM6 DDX20 HSPA4 GRSF1	1.52e-05	1425	89	14	30948266
Pubmed	Selectivity of the CUBAN domain in the recognition of ubiquitin and NEDD8.	CUL2 CUL1 USP13	1.52e-05	19	89	3	30659753
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	SLC38A1 SLK STX18 PNN COPG1 SYNE2 PRR14L HSPA4 HSP90AA1	1.55e-05	568	89	9	37774976
Pubmed	STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.	TRMT6 MAP1B MATR3 MCM6 HSPA4 GRSF1 HSP90AA1	1.74e-05	316	89	7	31665637
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	CUL1 RIF1 PNN COPG1 XPO6 ACIN1 MAGEE2 CDC27 HSP90AA1	1.87e-05	582	89	9	20467437
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	TICRR FRY TRMT6 CCDC73 COPG1 P3H1 PCDHB12 GLIPR1L2 MAGEE2 SUMO3	1.91e-05	736	89	10	29676528
Pubmed	Adaptive exchange sustains cullin-RING ubiquitin ligase networks and proper licensing of DNA replication.	CUL2 CUL1	1.94e-05	3	89	2	36037385
Pubmed	CAMKIIγ, HSP70 and HSP90 transcripts are differentially expressed in chronic myeloid leukemia cells from patients with resistant mutated disease.	HSPA4 HSP90AA1	1.94e-05	3	89	2	24206096
Pubmed	Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway.	HSPA4 HSP90AA1	1.94e-05	3	89	2	15798097
Pubmed	Heat Shock Proteins Promote Cancer: It's a Protection Racket.	HSPA4 HSP90AA1	1.94e-05	3	89	2	26874923
Pubmed	Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination.	HSPA4 HSP90AA1	1.94e-05	3	89	2	22128174
Pubmed	Basal and infection-induced levels of heat shock proteins in human aging.	HSPA4 HSP90AA1	1.94e-05	3	89	2	17211576
Pubmed	Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole.	HSPA4 HSP90AA1	1.94e-05	3	89	2	15383005
Pubmed	Does single gene expression omnibus data mining analysis apply for only tumors and not mental illness? A preliminary study on bipolar disorder based on bioinformatics methodology.	CUL1 HSP90AA1	1.94e-05	3	89	2	32871949
Pubmed	The APE2 Exonuclease Is a Client of the Hsp70-Hsp90 Axis in Yeast and Mammalian Cells.	HSPA4 HSP90AA1	1.94e-05	3	89	2	35883419
Pubmed	Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG.	HSPA4 HSP90AA1	1.94e-05	3	89	2	12775586
Pubmed	The regulatory mechanism of extracellular Hsp90{alpha} on matrix metalloproteinase-2 processing and tumor angiogenesis.	HSP90AA1 HSP90AA2P	1.94e-05	3	89	2	20937816
Pubmed	[Expressions of heat shock protein (HSP) family HSP 60, 70 and 90alpha in colorectal cancer tissues and their correlations to pathohistological characteristics].	HSPA4 HSP90AA1	1.94e-05	3	89	2	19635199
Pubmed	Recruitment of a cytoplasmic chaperone relay by the A2A adenosine receptor.	HSPA4 HSP90AA1	1.94e-05	3	89	2	23965991
Pubmed	Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness.	HSP90AA1 HSP90AA2P	1.94e-05	3	89	2	15146192
Pubmed	Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments.	HSPA4 HSP90AA1	1.94e-05	3	89	2	20804554
Pubmed	Interaction of PDZRhoGEF with microtubule-associated protein 1 light chains: link between microtubules, actin cytoskeleton, and neuronal polarity.	MAP1B ARHGEF11	1.94e-05	3	89	2	16478718
Pubmed	Inhibition of adjuvant-induced arthritis by DNA vaccination with the 70-kd or the 90-kd human heat-shock protein: immune cross-regulation with the 60-kd heat-shock protein.	HSPA4 HSP90AA1	1.94e-05	3	89	2	15529360
Pubmed	Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase.	HSPA4 HSP90AA1	1.94e-05	3	89	2	25452130
Pubmed	Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes.	HSPA4 HSP90AA1	1.94e-05	3	89	2	11877417
Pubmed	Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis.	VCX3A VCX3B	1.94e-05	3	89	2	18076704
Pubmed	PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation.	HSPA4 HSP90AA1	1.94e-05	3	89	2	14726529
Pubmed	Small glutamine-rich protein/viral protein U-binding protein is a novel cochaperone that affects heat shock protein 70 activity.	HSPA4 HSP90AA1	1.94e-05	3	89	2	12482202
Pubmed	Ubiquitin ligase Ufd2 is required for efficient degradation of Mps1 kinase.	UBE4B CDC27	1.94e-05	3	89	2	22045814
Pubmed	Small molecule perturbation of the CAND1-Cullin1-ubiquitin cycle stabilizes p53 and triggers Epstein-Barr virus reactivation.	CUL2 CUL1	1.94e-05	3	89	2	28715492
Pubmed	Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD.	HSPA4 HSP90AA1	1.94e-05	3	89	2	24355684
Pubmed	A dual interaction between the DNA damage response protein MDC1 and the RAG1 subunit of the V(D)J recombinase.	MDC1 CDC27	1.94e-05	3	89	2	22942284
Pubmed	The joining of the Hsp90 and Hsp70 chaperone cycles yields transient interactions and stable intermediates: insights from mass spectrometry.	HSPA4 HSP90AA1	1.94e-05	3	89	2	26286954
Pubmed	Knockdown of Minichromosome Maintenance Proteins Inhibits Foci Forming of Mediator of DNA-Damage Checkpoint 1 in Response to DNA Damage in Human Esophageal Squamous Cell Carcinoma TE-1 Cells.	MDC1 MCM6	1.94e-05	3	89	2	27908247
Pubmed	Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha.	HSPA4 HSP90AA1	1.94e-05	3	89	2	16507982
Pubmed	Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.	MAP1B PNN COPG1 MATR3 MCM6 SON	1.97e-05	215	89	6	30462309
Pubmed	CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex.	CUL2 CUL1 HSP90AA1	2.08e-05	21	89	3	12481031
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	TICRR RIF1 MAP1B PNN ATAD5 MATR3 ACIN1 GRSF1 AP3D1 SON	2.49e-05	759	89	10	35915203
Pubmed	Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3η as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability.	COPG1 P3H1 MATR3 MCM6 AP3D1 MAP3K19	2.55e-05	225	89	6	31478661
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	PNN COPG1 MATR3 ACIN1 MCM6 DDX20 SUMO3 CDC27 HSPA4 GRSF1 AP3D1 HSP90AA1 SON	3.03e-05	1318	89	13	30463901
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	CUL1 PNN COPG1 MATR3 MDC1 MCM6 DDX20 AP3D1 HSP90AA1 SON HSP90AA2P	3.09e-05	949	89	11	36574265
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	CUL2 CCP110 RIF1 STX18 NEK5 XPO6 APPL1 MCM6 DDX20 RPGR CDC27 SLC1A1 CCDC40	3.11e-05	1321	89	13	27173435
Pubmed	A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.	CUL2 CUL1 SUMO3	3.15e-05	24	89	3	16620772
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	PNN UBE4B MATR3 ACIN1 MCM6 HSPA4 HSP90AA1 SON	3.16e-05	477	89	8	31300519
Pubmed	The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells.	PNN MATR3 GMFG ACIN1 HSP90AA1 SON	3.57e-05	239	89	6	26641092
Pubmed	Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate.	SLK COPG1 MCM6	3.58e-05	25	89	3	27621311
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	MAP1B PNN SYNE2 MDC1 ACIN1 AP3D1 SON	3.86e-05	358	89	7	32460013
Pubmed	Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70.	HSPA4 HSP90AA1	3.87e-05	4	89	2	12526792
Pubmed	Effect of HSP70 and 90 in modulation of JNK, ERK expression in preeclamptic placental endothelial cell.	HSPA4 HSP90AA1	3.87e-05	4	89	2	22689214
Pubmed	Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing.	HSPA4 HSP90AA1	3.87e-05	4	89	2	14559896
Pubmed	The levels of retinoic acid-inducible gene I are regulated by heat shock protein 90-alpha.	HSP90AA1 HSP90AA2P	3.87e-05	4	89	2	19234166
Pubmed	Kv4.3 Modulates the Distribution of hERG.	HSPA4 HSP90AA1	3.87e-05	4	89	2	29259226
Pubmed	CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity.	HSPA4 HSP90AA1	3.87e-05	4	89	2	19196961
Pubmed	Ubiquitination and downregulation of ErbB2 and estrogen receptor-alpha by kinase inhibitor MP-412 in human breast cancer cells.	HSPA4 HSP90AA1	3.87e-05	4	89	2	21503962
Pubmed	Mapping of the gene family for human heat-shock protein 90 alpha to chromosomes 1, 4, 11, and 14.	HSP90AA1 HSP90AA2P	3.87e-05	4	89	2	1740332
Pubmed	The E3 ligase CHIP mediates ubiquitination and degradation of mixed-lineage kinase 3.	HSPA4 HSP90AA1	3.87e-05	4	89	2	24912674
Pubmed	Negative regulation of the Apaf-1 apoptosome by Hsp70.	HSPA4 HSP90AA1	3.87e-05	4	89	2	10934467
Pubmed	The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52.	HSPA4 HSP90AA1	3.87e-05	4	89	2	9392437
Interaction	CASP3 interactions	SLK KCNA10 RASA1 UBE4B MDC1 ACIN1 CDC27	3.32e-05	216	84	7	int:CASP3
Interaction	ARHGAP24 interactions	CUL2 CUL1 PNN COPG1 P3H1 MATR3 MCM6 ZNF236 HSPA4 HSP90AA1	3.39e-05	486	84	10	int:ARHGAP24
Interaction	KDR interactions	CUL1 RASA1 MDC1 ACIN1 HSP90AA1 SON	3.88e-05	150	84	6	int:KDR
Interaction	HDAC11 interactions	RIF1 PNN SYNE2 ACIN1 DDX20 SON	4.49e-05	154	84	6	int:HDAC11
Interaction	RPS6KL1 interactions	MAP1B DDX20 HSP90AA1 SON	6.04e-05	51	84	4	int:RPS6KL1
Interaction	SMC1A interactions	USP13 RIF1 FAM174A COPG1 MATR3 MDC1 ACIN1 MCM6 RPGR	6.07e-05	418	84	9	int:SMC1A
Interaction	TTC4 interactions	DCAF6 SLK TRMT6 UBE4B APPL1 HSP90AA1	6.60e-05	165	84	6	int:TTC4
Interaction	BCR interactions	RASA1 MAP1B PNN MCM6 DDX20 HSPA4 HSP90AA1	7.18e-05	244	84	7	int:BCR
Interaction	HSP90AA2P interactions	CUL2 CUL1 HSP90AA1 HSP90AA2P	8.15e-05	55	84	4	int:HSP90AA2P
Interaction	TTK interactions	FAM174A UBE4B XIRP2 CDC27 PTH2R HSP90AA1	8.57e-05	173	84	6	int:TTK
Interaction	RCBTB1 interactions	CUL2 CUL1 HSP90AA1	8.80e-05	21	84	3	int:RCBTB1
Interaction	RBM39 interactions	CUL1 MAGEA10 MAP1B PNN MATR3 MDC1 ACIN1 MCM6 DDX20 HSPA4 GRSF1 AP3D1 HSP90AA1 SON	9.59e-05	1042	84	14	int:RBM39
Interaction	COPS2 interactions	CUL2 CUL1 DCAF6 EHBP1L1 MAP1B ACIN1 EPB41L1	1.02e-04	258	84	7	int:COPS2
Interaction	USP37 interactions	CUL1 RIF1 PNN MCM6 CDC27	1.20e-04	115	84	5	int:USP37
GeneFamily	Variable charge X/Y family	VCX3A VCX3B VCX	7.26e-07	6	61	3	368
GeneFamily	Cullins	CUL2 CUL1	3.09e-04	8	61	2	1032
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HDA1	SLC38A1 LPIN1 FRY SLC8A1 ZFHX4 MAP1B ASXL3 PEG3 KCNIP4 CDH3 EPB41L1	4.15e-06	584	88	11	M39068
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3	CCP110 TICRR USP13 RIF1 TRMT6 RASA1 PNN ATAD5 XPO6 SYNE2 MDC1 RPGR CDC27 HSPA4 GRSF1 HSP90AA1 CCDC40	3.51e-06	1257	80	17	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3	USP13 RIF1 RASA1 MAP1B PNN ATAD5 ACIN1 ZC3H12C HSPA4 GRSF1 CCDC40	4.84e-06	532	80	11	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500	CCP110 TICRR USP13 RIF1 TRMT6 RASA1 MAP1B PNN ATAD5 XPO6 SYNE2 MDC1 RPGR CDC27 HSPA4 GRSF1 HSP90AA1 CCDC40	6.21e-06	1459	80	18	facebase_RNAseq_e10.5_Emin_LatNas_2500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_2500_k-means-cluster#4	CCP110 SLK ZNF142 FAM174A MAP1B MATR3 SYNE2 MDC1 RPGR ZFX SON	1.39e-05	595	80	11	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_2500_K4
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_500_k-means-cluster#5	RIF1 MAP1B PNN ATAD5 SYNE2 ZC3H12C HSPA4	2.74e-05	232	80	7	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_500_K5
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_MedNas_2500_K1	CCP110 TICRR RIF1 RASA1 MAP1B PNN ATAD5 SYNE2 MAGEE2 ZC3H12C RPGR HSPA4 HSP90AA1 CCDC40	3.78e-05	1060	80	14	facebase_RNAseq_e10.5_Emin_MedNas_2500_K1
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500_k-means-cluster#3	RIF1 PNN ATAD5 SYNE2 HSPA4 MAP3K19	8.72e-05	192	80	6	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500	RIF1 MAP1B PNN ATAD5 SYNE2 ZC3H12C HSPA4 HSP90AA1 MAP3K19	1.06e-04	498	80	9	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500
CoexpressionAtlas	DevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#1_top-relative-expression-ranked_1000	RIF1 PNN ASXL3 PEG3 ACIN1	1.06e-04	124	80	5	gudmap_developingGonad_e16.5_epididymis_1000_k1
CoexpressionAtlas	FacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#5	RIF1 SLK ZNF142 PNN ATAD5 SYNE2 HSPA4 EPB41L1 MAP3K19 SON	1.23e-04	629	80	10	Facebase_RNAseq_e10.5_Maxillary Arch_2500_K5
CoexpressionAtlas	FacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_1000_k-means-cluster#4	TICRR RASA1 PNN ASXL3 MDC1 RPGR HSPA4	1.32e-04	298	80	7	Facebase_RNAseq_e10.5_Medial Nasal Eminence_1000_K4
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000_k-means-cluster#2	RIF1 PNN ATAD5 SYNE2 RPGR HSPA4 MAP3K19	1.72e-04	311	80	7	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000_K2
CoexpressionAtlas	DevelopingGonad_e11.5_ovary + mesonephros_emap-3226_top-relative-expression-ranked_500	RIF1 ZFHX4 MAP1B ASXL3 SYNE2 PEG3 ACIN1 RPGR	1.74e-04	417	80	8	gudmap_developingGonad_e11.5_ovary + mesonephros_500
CoexpressionAtlas	ratio_EmbryoidBody-blastocyst_vs_EmbryoidBody-fibro_top-relative-expression-ranked_2500_k-means-cluster#5	ZFHX4 ASXL3 PEG3 KCNIP4 MAP3K19	1.75e-04	138	80	5	ratio_EB-blastocyst_vs_EB-fibro_2500_K5
CoexpressionAtlas	facebase_RNAseq_e10.5_MaxArch_2500_K3	CCP110 TICRR RIF1 TRMT6 RASA1 PNN ATAD5 XPO6 SYNE2 RPGR CDC27 HSPA4 HSP90AA1 CCDC40	2.22e-04	1252	80	14	facebase_RNAseq_e10.5_MaxArch_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_1000_k-means-cluster#3	TICRR RIF1 SLK ZFHX4 PNN ATAD5 HSPA4 MAP3K19	2.22e-04	432	80	8	Facebase_RNAseq_e10.5_Maxillary Arch_1000_K3
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000	CUL2 CCP110 TICRR RIF1 DCAF6 CCDC73 MDC1 TOP6BL RPGR GRSF1 HSP90AA1	2.45e-04	820	80	11	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000	SLC38A1 RIF1 TRMT6 MAP1B PNN ATAD5 SYNE2 ZC3H12C RPGR HSPA4 HSP90AA1 MAP3K19	3.16e-04	989	80	12	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_1000	TICRR RIF1 SLK TRMT6 ZFHX4 PNN ATAD5 SYNE2 GMFG RPGR HSPA4 MAP3K19	3.16e-04	989	80	12	Facebase_RNAseq_e10.5_Maxillary Arch_1000
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_1000_k-means-cluster#1	CCP110 MAP1B PNN MDC1 ACIN1 CCDC40	4.39e-04	259	80	6	Facebase_RNAseq_e8.5_Floor Plate_1000_K1
CoexpressionAtlas	FacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_500	ZFHX4 PNN ASXL3 SYNE2 GMFG MAGEE2 RPGR HSPA4	5.28e-04	492	80	8	Facebase_RNAseq_e10.5_Lateral Nasal Eminence_500
CoexpressionAtlas	facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4	SLC38A1 CCP110 TICRR MAP1B PNN ATAD5 SYNE2 PEG3 SUMO3 ZC3H12C HSPA4 GRSF1 HSP90AA1 CCDC40	5.51e-04	1370	80	14	facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRY ASXL3 KCNIP4 TOP6BL PTH2R SLC45A4	1.61e-06	179	89	6	d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC38A1 FRY KCNIP4 TOP6BL PTH2R SLC45A4	1.72e-06	181	89	6	aa233b652921848af2257cc3687a7a09c3acfb67
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC8A1 COL12A1 STAB2 ZFHX4 XIRP2 ASXL3	1.89e-06	184	89	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC8A1 COL12A1 STAB2 ZFHX4 XIRP2 ASXL3	1.89e-06	184	89	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC8A1 COL12A1 STAB2 ZFHX4 XIRP2 ASXL3	1.89e-06	184	89	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC38A1 FRY SLC8A1 ASXL3 KCNIP4 TOP6BL	2.28e-06	190	89	6	4836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC38A1 SYNE2 KCNIP4 TOP6BL EPB41L1 SLC45A4	2.81e-06	197	89	6	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	(10)_Ciliated-(2)_GFP_FOXI1\|(10)_Ciliated / shred by cell type by condition	SYNE2 ANKRD36 RPGR CDC27 AP3D1 HSP90AA1	2.97e-06	199	89	6	61b1ed2db71b96157b92b7535d1955a4033098da
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	USP13 CCDC73 MATR3 MCM6 MAP3K19	1.74e-05	160	89	5	50d4f867d021abcfeb49e6812bcfd5bb57466a31
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	USP13 CCDC73 MATR3 MCM6 MAP3K19	1.74e-05	160	89	5	0f15f895f11dcabb73df79b26bfc4947f38435a7
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	USP13 CCDC73 MATR3 MCM6 MAP3K19	1.74e-05	160	89	5	7d004bfe42707605b3851cb2319126acda4d4802
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SLC38A1 RASA1 SYNE2 ANKRD36 ANKRD36C	2.14e-05	167	89	5	83969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RIF1 CCDC73 ATAD5 PRR14L CDH3	2.20e-05	168	89	5	08f6e171a1ea5cf65149744296d0fcd6c7b9684e
ToppCell	normal_Pleural_Fluid-Myeloid_cells-CD163+CD14+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	SLC38A1 NEK5 SYNE2 ANKRD36 TOP6BL	2.27e-05	169	89	5	bea8aba1f3cc3d0e8d448c1c45f5354d26ebf850
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC8A1 PNN XIRP2 MATR3 PEG3	2.75e-05	176	89	5	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Mesenchymal_1\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SLC8A1 ZFHX4 KCNIP4 SPARCL1 CDH3	3.15e-05	181	89	5	7e3bcfa2ba5b98a7df5854aa6e7a31e9a71faa8a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC38A1 SLC8A1 KCNIP4 TOP6BL EPB41L1	3.59e-05	186	89	5	d65fa6d8e8a195ea10cfde1499d096d6acf7a634
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC38A1 FRY SLC8A1 KCNIP4 TOP6BL	3.87e-05	189	89	5	8ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRY SLC8A1 EHBP1L1 MAP1B SPARCL1	3.87e-05	189	89	5	127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRY SLC8A1 EHBP1L1 MAP1B SPARCL1	3.87e-05	189	89	5	2cfb4d12f75678d1619f4743838a0e954bd57761
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CCP110 USP13 ANKRD36 ANKRD36C MAP3K19	3.97e-05	190	89	5	0adb24dafa077156bbc73a8d8cbf3d9eeb6e08df
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CCP110 USP13 ANKRD36 ANKRD36C MAP3K19	3.97e-05	190	89	5	05455775845f4ded5c27e7b83242078d23162aaf
ToppCell	COVID-19-kidney-CNT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC8A1 KCNIP4 TOP6BL PTH2R EPB41L1	4.17e-05	192	89	5	760c6b9628de9693034b00c5025c5c4df94bb2e8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC38A1 FRY KCNIP4 TOP6BL SLC45A4	4.17e-05	192	89	5	fd08ae787e936cfdb1ab8f19b0fd63005b462709
ToppCell	H1299-infected\|H1299 / Cell line, Condition and Strain	SLC38A1 PNN ANKRD36 ANKRD36C SON	4.17e-05	192	89	5	9cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCell	droplet-Pancreas-Endocrine\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP1B COPG1 PEG3 HSP90AA1 SON	4.17e-05	192	89	5	0dfd1e9896c34aee0f842f8de5d0e3af62a15f68
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC38A1 FRY KCNIP4 TOP6BL SLC45A4	4.17e-05	192	89	5	bae236c9f1fac77bce28d0a9cf090100d391ff77
ToppCell	COVID-19-kidney-CD-PC\|kidney / Disease (COVID-19 only), tissue and cell type	SLC38A1 FRY SLC8A1 KCNIP4 TOP6BL	4.27e-05	193	89	5	738689d009e4b118d7ce3171a207294b95cbe78b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE2 KCNIP4 TOP6BL PTH2R EPB41L1	4.38e-05	194	89	5	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	Fibroblasts-Pericytes\|Fibroblasts / lung cells shred on cell class, cell subclass, sample id	SLC38A1 FRY MAP1B SYNE2 SPARCL1	4.49e-05	195	89	5	c2ebc0b33bda9b35b9ef26d69e5d2c6acfdb6ff1
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIF1 SLC8A1 MAP1B PEG3 SON	4.49e-05	195	89	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	(0)_NK_cells-(0)_NK_CD160pos\|(0)_NK_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	LPIN1 RASA1 PNN HSP90AA1 SON	4.49e-05	195	89	5	6cbeceb52bb207f3c074e57b5b3f7cfb24fd5877
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SLC38A1 SYNE2 ANKRD36 RPGR ANKRD36C	4.49e-05	195	89	5	ed5f772c82d4dfd1c8735224446ec9feae3fb8c2
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIF1 SLC8A1 MAP1B PEG3 SON	4.49e-05	195	89	5	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC38A1 ZFHX4 TOP6BL EPB41L1 SLC45A4	4.60e-05	196	89	5	c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SLC38A1 PNN MATR3 SYNE2 SON	4.60e-05	196	89	5	a9157809122e6fc5783a291522f103bef30943e4
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Calb1-Excitatory_Neuron.Sc17a7.Calb1-Ddit4l_(Neurofilament,_Layer4?)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	XIRP2 ANKRD36 PTH2R	4.68e-05	35	89	3	afb8cd52dffd630ffe8e7812874d5fd52e0b6752
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FRY SLC8A1 MAP1B SPARCL1 TRAV38-2DV8	4.71e-05	197	89	5	bf0520a94ebb1d2f94de9f526d17e0b0e8fe7052
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	MAP1B PNN ANKRD36 ANKRD36C HSP90AA1	4.71e-05	197	89	5	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FRY SLC8A1 MAP1B PEG3 KCNIP4	4.83e-05	198	89	5	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-early_osteoblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	COL12A1 ZFHX4 MAP1B P3H1 SPARCL1	4.83e-05	198	89	5	6a539d3b47bd2d4a7ad5c67cad23facffc0ac45f
ToppCell	metastatic_Brain-Fibroblasts-Pericytes\|Fibroblasts / Location, Cell class and cell subclass	MAP1B SYNE2 GMFG SPARCL1 EPB41L1	4.83e-05	198	89	5	86a4c8e859ce11a95875f8844963baeb1ba898ec
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	LPIN1 PNN SYNE2 ANKRD36 ANKRD36C	4.94e-05	199	89	5	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-FOXM1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CCP110 TICRR USP13 ATAD5 SYNE2	4.94e-05	199	89	5	98575fcce726589e93fbb4df1aab03e57cb56076
ToppCell	(01)_IL1RL1+-(2)_GFP_FOXI1\|(01)_IL1RL1+ / shred by cell type by condition	PNN SYNE2 APPL1 CDC27 HSP90AA1	4.94e-05	199	89	5	a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCell	3'_v3-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	CRYBA1 SYNE2 ANKRD36 ANKRD36C	1.02e-04	121	89	4	19333a660800b583fa27b495c1f7828e6636a257
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNIP4 TOP6BL PTH2R NLRP13	1.38e-04	131	89	4	d706405453408fbcfcabb1c7702b80f9e649ffca
ToppCell	AT1-AT2_cells-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	USP13 COL12A1 VCX3A SLC1A1	1.79e-04	140	89	4	45d52a086ced8d58e01ac51ac4a90338e8649b16
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic-T_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SLC38A1 RASA1 SYNE2 ANKRD36	2.33e-04	150	89	4	c922dbb4c9c12ccf08bd5f6168b20606c605d052
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	SLC38A1 SYNE2 ANKRD36 ANKRD36C	2.39e-04	151	89	4	999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNIP4 TOP6BL PTH2R SLC45A4	2.39e-04	151	89	4	f4f7156b2c0cfc78fd1841e07c9915d97ced561f
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF142 ASXL3 SYNE2 MCM6	2.83e-04	158	89	4	5775246e192629058ed89fb56031bdf4cbb9c15c
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	SLC38A1 RASA1 SYNE2 ANKRD36C	3.12e-04	162	89	4	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	Bronchial_Biopsy-Endothelial-Lymphatic\|Endothelial / Tissue, Lineage and Cell class of Lung Cells from 10X	CYB5RL STAB2 ZFHX4 PCDHB12	3.19e-04	163	89	4	961c3a1303108afd680365466045f3460a30a7b0
ToppCell	10x5'v1-week_12-13-Hematopoietic-HSC/MPP_and_pro-MEP\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	PNN XIRP2 MATR3 PCDHB12	3.26e-04	164	89	4	47355439e578d1b1a387fb4ee761162028abea4a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC8A1 ASXL3 KCNIP4 TOP6BL	3.34e-04	165	89	4	9bd332e5ede759a00a47728ea5558c215efdd77a
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNN PEG3 AP3D1 SON	3.42e-04	166	89	4	66026988509e39e41274fa0de738383219e8ff30
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SLC38A1 CYB5RL SYNE2 MCM6	3.50e-04	167	89	4	ded4d6cccd3660662f12cf5a512de31d26325f1b
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition,_dividing_(more_DN)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CUL2 CCP110 DDX20 CCDC40	3.58e-04	168	89	4	b9db0b1e4fe54a1fe79530d15d206155a1bfac39
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CABYR ASXL3 KCNIP4 CDH3	3.66e-04	169	89	4	3f738fc56bbc70dc77c9ba41025631f8264cd2b3
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC38A1 STAB2 ATAD5 MCM6	3.66e-04	169	89	4	20fbf78382fb0ba9a63ab1aa0abc615476994ac5
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CUL2 SYNE2 GMFG ZC3H12C	3.91e-04	172	89	4	eee45759284baa3ed77da6a5fbcc4f8f6c553106
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TICRR SLC8A1 ATAD5 FPR3	3.91e-04	172	89	4	ef33b5e0515c6d29fb6d9a673011c1b68ef264f3
ToppCell	343B-Myeloid-Dendritic-cDC_proliferating_2\|343B / Donor, Lineage, Cell class and subclass (all cells)	TICRR ATAD5 FPR3 MCM6	4.08e-04	174	89	4	a75ba49ccea6bd3d78ada1092b46deb5202c58a5
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(RGS5+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FRY NEK5 PEG3 CDH3	4.17e-04	175	89	4	f5451c29c487b998778e50349b3d774d5e20fd28
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLK PEG3 MCM6 SPARCL1	4.26e-04	176	89	4	269326c2bf44a9003d95bc6dbc839f08f25737ca
ToppCell	COVID-19-Heart-CM_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	USP13 FRY SLC8A1 XIRP2	4.26e-04	176	89	4	9df7a124ebafb0087da0cda133a394275d7bed81
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CUL1 PCDHB12 MCM6 SPARCL1	4.26e-04	176	89	4	cb8fd56a4f935cdda19d7ab43382cdda7c307667
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	KCNIP4 HSPA4 PTH2R EPB41L1	4.26e-04	176	89	4	36f77d878a53b30465b0dea8333a3865dba75613
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_12\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CRYBA1 USP13 SLC8A1 MCM6	4.36e-04	177	89	4	cbedac0bddb8fc330a464815c905928c553b0fc0
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_12\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CRYBA1 USP13 SLC8A1 MCM6	4.45e-04	178	89	4	04bfecf5ea5d85c843e48d08718b5d69e7bf834e
ToppCell	Mid-temporal_gyrus_(MTG)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PNN XIRP2 ANKRD36 ANKRD36C	4.45e-04	178	89	4	ad187db4c40b9078d54dd915c143e0172b2f47b8
ToppCell	facs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRY SLC8A1 MAP1B EPB41L1	4.54e-04	179	89	4	8da6863edc756540bb097cc7221c1408640d9bb4
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SLC38A1 STAB2 GMFG FBXO39	4.54e-04	179	89	4	ab3d08b51cd7a37582305615ee221c7a2af83b40
ToppCell	facs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRY SLC8A1 MAP1B EPB41L1	4.54e-04	179	89	4	f39c13c99a07d009cc677e363ffe089089c64916
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SLC38A1 STAB2 GMFG FBXO39	4.54e-04	179	89	4	35fe9961e228ce255e3317fc244efa35b5adbf8b
ToppCell	human_hepatoblastoma-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	LPIN1 FRY ZFHX4 XIRP2	4.54e-04	179	89	4	14fc8ccb6b215063d747643f47d780d2b237eb67
ToppCell	facs-Liver-Non-hepatocytes-3m-Lymphocytic-T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCP110 TICRR NEK5 ATAD5	4.64e-04	180	89	4	87347af8f28cf7c486c19f3f98c0afb022c323b5
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CCP110 NEK5 MAP3K19 CCDC40	4.64e-04	180	89	4	92fb01b91261b3103454924cde56add337b41844
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	SLC38A1 SYNE2 ANKRD36 ANKRD36C	4.74e-04	181	89	4	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNIP4 CDH3 EPB41L1 SLC45A4	4.74e-04	181	89	4	22363c5835dd6cef8f895ab9362e0837d92b15b1
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	USP13 FRY SLC8A1 XIRP2	4.84e-04	182	89	4	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	COVID-19_Mild\|World / Disease Group and Platelet Clusters	XIRP2 MATR3 SYNE2 MCM6	4.84e-04	182	89	4	90c61e10c7860bfba6ccfe6f37671c8924637f7b
ToppCell	COVID-19-kidney-PCT-S1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SYNE2 KCNIP4 SLC1A1 PTH2R	4.94e-04	183	89	4	6878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCell	normal-na-Lymphocytic_T-CytoT_GZMK+-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	SLC38A1 SYNE2 ANKRD36 HSP90AA1	4.94e-04	183	89	4	79defd22b3194dad16db55b9bdd220c09c1e6b90
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC38A1 SLC8A1 KCNIP4 TOP6BL	4.94e-04	183	89	4	d340ab5a77e8d819a1dfb4ca3e9a4b9bc988923c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC38A1 SLC8A1 KCNIP4 TOP6BL	5.04e-04	184	89	4	9690d4290e70f9bda889754ffb30b0af1f7cb94b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRY COL12A1 MAP1B SPARCL1	5.14e-04	185	89	4	51dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D175\|Adult / Lineage, Cell type, age group and donor	CCP110 COL12A1 TOP6BL ZC3H12C	5.14e-04	185	89	4	32b4e68e551d435a732f253f6ad83408c759a642
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC38A1 FRY TOP6BL SLC45A4	5.14e-04	185	89	4	a0a629e5d2b65f670ea907bd3f5e3caf17687d8f
ToppCell	NS-moderate-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MAP1B NEK5 MAP3K19 CCDC40	5.14e-04	185	89	4	5e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCell	Ciliated_cells-A-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	MAP1B NEK5 ASXL3 MAP3K19	5.14e-04	185	89	4	d77ca57b02125a3a57a37f4aed20c89803b7d551
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC38A1 SLC8A1 KCNIP4 TOP6BL	5.14e-04	185	89	4	3d73b3e0bceb192257e5cfbe64b7ccb379b6e22d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRY COL12A1 MAP1B SPARCL1	5.14e-04	185	89	4	a8c02cec3c414f3a0da9f2d6d28ce563b0030705
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC38A1 TRMT6 MAGEE2 SLC45A4	5.25e-04	186	89	4	aeac0c2db173cd1ea45b5052ab418d6cacd198d8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC38A1 SLC8A1 KCNIP4 TOP6BL	5.25e-04	186	89	4	08632045d499e61dd96ff29a5a9a208afe58dc58
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	CUL2 CABYR GPR108 CCDC40	5.25e-04	186	89	4	b9e0a819cd0b250f077b26eba99e6986d68d647b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC38A1 SLC8A1 KCNIP4 TOP6BL	5.25e-04	186	89	4	b3358e0fa6d845c81e94d56c8575f016621d28ff
ToppCell	metastatic_Lymph_Node-Endothelial_cells-Tumor_ECs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	FRY ASXL3 MDC1 SPARCL1	5.36e-04	187	89	4	2713f526f86911fbbf6c7a3e69230f2e6bde31c3
ToppCell	COVID-19-Fibroblasts-Airway_smooth_muscle\|COVID-19 / group, cell type (main and fine annotations)	FRY COL12A1 MAP1B SPARCL1	5.36e-04	187	89	4	464a0c3b92b778911b5f9cd73642e09e3472063a
Computational	Genes upregulated in subsets of cells of a given type within various tumors	RIF1 SLK ATAD5 SYNE2	6.93e-05	50	48	4	GAVISH_3CA_MALIGNANT_METAPROGRAM_4_CHROMATIN
Drug	geldanamycin	SLC38A1 SLC8A1 COL12A1 ZFHX4 MAP1B MATR3 PRR14L CDC27 HSPA4 ZFX HSP90AA1	1.72e-07	371	87	11	ctd:C001277
Drug	1,1-diphenyl-2-propyn-1-ol	HSPA4 HSP90AA1 HSP90AA2P	5.36e-07	5	87	3	CID000092976
Drug	17-aminogeldanamycin	HSPA4 HSP90AA1 HSP90AA2P	1.87e-06	7	87	3	CID000429444
Drug	phenyldichloroarsine	HSPA4 HSP90AA1 HSP90AA2P	2.98e-06	8	87	3	CID000012762
Drug	GGMP	HSPA4 HSP90AA1 HSP90AA2P	2.98e-06	8	87	3	CID006443839
Drug	antheridiol	HSPA4 HSP90AA1 HSP90AA2P	4.45e-06	9	87	3	CID000159927
Drug	Pu-3	HSPA4 HSP90AA1 HSP90AA2P	8.70e-06	11	87	3	CID000448965
Drug	2qfo	HSP90AA1 HSP90AA2P	1.44e-05	2	87	2	CID000600769
Drug	3-amino-5-chlorobenzoic acid	HSP90AA1 HSP90AA2P	1.44e-05	2	87	2	CID010986726
Drug	3eko	HSP90AA1 HSP90AA2P	1.44e-05	2	87	2	CID011160307
Drug	monocillin III	HSP90AA1 HSP90AA2P	1.44e-05	2	87	2	CID006478910
Drug	pochonin A	HSP90AA1 HSP90AA2P	1.44e-05	2	87	2	CID006478909
Drug	1uyi	HSP90AA1 HSP90AA2P	1.44e-05	2	87	2	CID005289232
Drug	PU-H71	HSP90AA1 HSP90AA2P	1.44e-05	2	87	2	CID009549213
Drug	NSC683666	HSP90AA1 HSP90AA2P	1.44e-05	2	87	2	CID005469153
Drug	H 64	HSP90AA1 HSP90AA2P	1.44e-05	2	87	2	CID006914564
Drug	SureCN4151355	HSP90AA1 HSP90AA2P	1.44e-05	2	87	2	CID015942101
Drug	1uyc	HSP90AA1 HSP90AA2P	1.44e-05	2	87	2	CID000448969
Drug	PU-9	HSP90AA1 HSP90AA2P	1.44e-05	2	87	2	CID000448971
Drug	P u 0	HSP90AA1 HSP90AA2P	1.44e-05	2	87	2	CID000448974
Drug	2qf6	HSP90AA1 HSP90AA2P	1.44e-05	2	87	2	CID013373715
Drug	CHEBI:42139	HSP90AA1 HSP90AA2P	1.44e-05	2	87	2	CID011562562
Drug	NSC 255110	HSPA4 HSP90AA1 HSP90AA2P	1.50e-05	13	87	3	CID000318505
Drug	2-chlorodideoxyadenosine	VCX3B VCX HSP90AA1 HSP90AA2P	2.19e-05	43	87	4	CID000072194
Drug	PPTP	HSPA4 HSP90AA1 HSP90AA2P	2.91e-05	16	87	3	CID000146272
Drug	pochonin D	HSP90AA1 HSP90AA2P	4.32e-05	3	87	2	CID006478913
Drug	azaquinone	HSP90AA1 HSP90AA2P	4.32e-05	3	87	2	CID000099132
Drug	d 1 v	HSP90AA1 HSP90AA2P	4.32e-05	3	87	2	CID000683940
Drug	HM-9	HSP90AA1 HSP90AA2P	4.32e-05	3	87	2	CID000433437
Drug	Glyoxylspermidine	HSP90AA1 HSP90AA2P	4.32e-05	3	87	2	CID000133564
Drug	AC1MD0RC	HSP90AA1 HSP90AA2P	4.32e-05	3	87	2	CID002829073
Drug	CGP7040	HSPA4 HSP90AA1 HSP90AA2P	5.86e-05	20	87	3	CID006436259
Drug	chlorobenzilate	HSPA4 HSP90AA1 HSP90AA2P	5.86e-05	20	87	3	CID000010522
Drug	NCI60_002052	HSPA4 HSP90AA1 HSP90AA2P	5.86e-05	20	87	3	CID006801032
Drug	Ab-9	HSPA4 HSP90AA1 HSP90AA2P	6.82e-05	21	87	3	CID006540280
Drug	uranyl chloride	HSP90AA1 HSP90AA2P	8.62e-05	4	87	2	CID000082259
Drug	methoxyhydroquinone	HSP90AA1 HSP90AA2P	8.62e-05	4	87	2	CID000069988
Drug	11p110	HSP90AA1 HSP90AA2P	8.62e-05	4	87	2	CID002382787
Drug	Imipenem [74431-23-5]; Down 200; 13.4uM; MCF7; HT_HG-U133A	CABYR MAP1B UBE4B ATAD5 TOP6BL RPGR	9.26e-05	191	87	6	5997_DN
Drug	pU-2	SYNE2 HSP90AA1 HSP90AA2P	1.17e-04	25	87	3	CID000448973
Drug	AC1L1HOS	HSPA4 HSP90AA1 HSP90AA2P	1.17e-04	25	87	3	CID000004223
Drug	KNK437	HSPA4 HSP90AA1 HSP90AA2P	1.31e-04	26	87	3	CID009859662
Drug	1uy7	HSP90AA1 HSP90AA2P	1.43e-04	5	87	2	CID005289227
Drug	1uyd	HSP90AA1 HSP90AA2P	1.43e-04	5	87	2	CID000448970
Drug	Org 31806	HSP90AA1 HSP90AA2P	1.43e-04	5	87	2	CID000164147
Drug	CRT0044876	HSP90AA1 HSP90AA2P	1.43e-04	5	87	2	CID000081409
Drug	HCV-796	HSP90AA1 HSP90AA2P	1.43e-04	5	87	2	CID011561383
Drug	chaetochromin	HSP90AA1 HSP90AA2P	1.43e-04	5	87	2	CID000053277
Drug	PeCDD	APPL1 HSP90AA1 HSP90AA2P	1.48e-04	27	87	3	CID000038439
Drug	TM02	HSPA4 HSP90AA1 HSP90AA2P	1.65e-04	28	87	3	CID000012902
Drug	DB07586	VCX3A VCX3B VCX ZFX	1.87e-04	74	87	4	CID005287979
Drug	AC1O5WLA	HSPA4 HSP90AA1 HSP90AA2P	2.03e-04	30	87	3	CID006442113
Drug	bacteriochlorin A	RIF1 FPR3	2.14e-04	6	87	2	CID000159279
Drug	Hantzsch ester	HSP90AA1 HSP90AA2P	2.14e-04	6	87	2	CID000070849
Drug	3-aminocoumarin	HSP90AA1 HSP90AA2P	2.14e-04	6	87	2	CID000074217
Drug	Pu x	HSP90AA1 HSP90AA2P	2.14e-04	6	87	2	CID000448976
Drug	9-methyluric acid	SYNE2 VCX3B VCX	2.24e-04	31	87	3	CID000108714
Drug	15-deoxyspergualin	HSPA4 HSP90AA1 HSP90AA2P	2.47e-04	32	87	3	CID000055361
Drug	Nepl	HSP90AA1 HSP90AA2P	2.99e-04	7	87	2	CID006439214
Drug	NSC330499	HSP90AA1 HSP90AA2P	2.99e-04	7	87	2	CID000433447
Drug	1,2,4,7,8-pentachlorodibenzo-p-dioxin	HSP90AA1 HSP90AA2P	2.99e-04	7	87	2	CID000042836
Drug	Zlll-mca	HSP90AA1 HSP90AA2P	2.99e-04	7	87	2	CID000132936
Drug	dienochlor	HSP90AA1 HSP90AA2P	2.99e-04	7	87	2	CID000016686
Disease	Uterine leiomyoma, breast carcinoma	EHBP1L1 ATAD5 HSPA4	1.04e-04	32	84	3	EFO_0000305, HP_0000131
Disease	Uterine leiomyoma, estrogen-receptor positive breast cancer	ATAD5 HSPA4	1.19e-03	18	84	2	EFO_1000649, HP_0000131
Disease	Retinal Degeneration	RPGR SLC1A1	1.62e-03	21	84	2	C0035304
Disease	Epilepsy, Cryptogenic	ASXL3 SPARCL1 SLC1A1	1.68e-03	82	84	3	C0086237
Disease	Awakening Epilepsy	ASXL3 SPARCL1 SLC1A1	1.68e-03	82	84	3	C0751111
Disease	Aura	ASXL3 SPARCL1 SLC1A1	1.68e-03	82	84	3	C0236018

Protein segments in the cluster

Peptide	Gene	Start	Entry
TQSLREQPEMEDANS	PRPF4B	6	Q13523
EVTMDTSENRPENDV	ACIN1	771	Q9UKV3
MENSLSDPENEQTVQ	ATAD5	351	Q96QE3
TMETQAAQEPEDDLT	ARHGEF11	1221	O15085
PTQMEKSTDTDEDNV	CABYR	96	O75952
DVQTSTPAEQDLEMA	ANKRD36	1286	A6QL64
ETAMEVDTPAEQFLQ	DCAF6	396	Q58WW2
QSEEQMKNSVQTPVE	DDX20	541	Q9UHI6
DMELQSDPEEQLSEN	ASXL3	591	Q9C0F0
AQQVDIVTEEMPENA	AP3D1	771	O14617
VPMQDQEQVLNDTVD	RASA1	441	P20936
MEPTIQNSDIVFAEN	IMMP1L	41	Q96LU5
EEMDLSQEQPLDAQQ	P3H1	701	Q32P28
EVNEDIQPMTAFESE	GRSF1	361	Q12849
VQTSTPEQDLEMASE	ANKRD36C	1151	Q5JPF3
QQDTRPAEQSLDMEE	EPB41L1	51	Q9H4G0
TPDVNLDQEEEIQME	MCM6	661	Q14566
DVMSDETNNEETESP	MAP1B	1141	P46821
DDQTEQEPNMLLESE	MATR3	641	P43243
MPEEDLQSQSETQGL	MAGEA10	11	P43363
QGLEAVQSMEDEPTQ	MDC1	706	Q14676
VQQPESEEEQVMLES	MAGEE2	381	Q8TD90
QQTPAENKAESEEME	HSPA4	536	P34932
QMIFTPEESEAGNEE	GLIPR1L2	286	Q4G1C9
QMVVLEEEFQNISPE	GMFG	41	O60234
TMQQTIEDLEVASDP	APPL1	246	Q9UKG1
METNFSIPLNETEEV	FPR3	1	P25089
METNRVESVEPSENE	PNN	406	Q9H307
QEEEAMDIPNETLTF	NEK5	596	Q6P3R8
MDEESELIQPQDQSC	FBXO39	1	Q8N4B4
PAIQNSVEDELEMAT	KCNIP4	51	Q6PIL6
MVPILQSITDNENDE	CYB5RL	196	Q6IPT4
EDTIQSEMLGTQETE	EHBP1L1	691	Q8N3D4
PQTEMQFVNEEDLET	LPIN1	336	Q14693
QETIEDPVIQGSDME	PEG3	1081	Q9GZU2
QVMDVNDNAPEITVS	PCDHB12	336	Q9Y5F1
TELVQETEPSAQQNM	KCNA10	321	Q16322
TVNDMQLTDLVPNTE	COL12A1	1526	Q99715
NPEEAELEDTLNQVM	CUL1	436	Q13616
DQIQQPSTEEGAMAE	CCDC40	246	Q4G0X9
NVPEVNNENSEMSTE	CCDC73	396	Q6ZRK6
METQAEQQELETLPT	CRYBA1	1	P05813
TPQEMEQTRSAVDED	CUL2	661	Q13617
IIQDTDENTNVPEIM	CCP110	411	O43303
DEDLQSAIVQPSQMQ	MS4A14	276	Q96JA4
DQTLENVTVQMEPTE	COPG1	671	Q9Y678
NLPQMTQEVEDVDTA	FRY	1771	Q5TBA9
QTQDQPMEEEEVETF	HSP90AA1	6	P07900
DDEEPITQEEQIMGT	CDC27	786	P30260
ITQEEQIMGTDESQE	CDC27	791	P30260
EDPMNISIIVTDQND	CDH3	196	P22223
EQMDVSSEVNIVNPF	SLC1A1	471	P43005
QTQDQPMEEEEVETF	HSP90AA2P	6	Q14568
ETQHSEITPSQDEEM	MAP3K19	396	Q56UN5
MPSQENSETNVNSEE	PRR14L	1241	Q5THK1
TNIENMELTPLEQDD	FAM174A	161	Q8TBP5
QESVLSEQDLMQPEE	RPGR	456	Q92834
QESQVEEPLSQESEM	VCX3A	166	Q9NNX9
INSSENIMDINEEPG	SLK	621	Q9H2G2
QESQVEEPLSQESEM	VCX3B	196	Q9H321
QESEMEEPLSQESQV	VCX3B	206	Q9H321
QESQVEEPLSQESEM	VCX3B	216	Q9H321
QVESSEEDQSQTMDP	TOP6BL	306	Q8N6T0
EEDQSQTMDPQGQTL	TOP6BL	311	Q8N6T0
SENETDMEDPREIQT	SYNE2	6361	Q8WXH0
TEEQMDSDIVIPQDV	RIF1	1121	Q5UIP0
QLPQEDEEDVQMEQV	GPR108	506	Q9NPR9
INETDTPAQLEMEDE	SUMO3	66	P55854
QNADPESMQVQELSV	SLC45A4	6	Q5BKX6
QLLPVEQDTSNVTEM	XIRP2	2036	A4UGR9
NNSPSEEQIQEMAEK	ZFHX4	2106	Q86UP3
LQCPSINESTDDMEQ	TICRR	731	Q7Z2Z1
QSQPEMSVQEAETVT	TRA	26	P0DTU3
ELSPEEIQMFEQENQ	STX18	226	Q9P2W9
LEDMIQELQETPSQT	WDR97	1351	A6NE52
ESDQPTQVSKMQEDE	SPARCL1	246	Q14515
PNDETRVNATMEDVN	UBE4B	721	O95155
VLVPSQQATEDMDQD	STAB2	1031	Q8WWQ8
NLQEDETEEMEGPQS	WDR53	176	Q7Z5U6
QESQVEEPLSQESEM	VCX	166	Q9H320
QESEMEEPLSQESQV	VCX	176	Q9H320
ESLIMQDDPQNSIEA	PTH2R	211	P49190
ESNHPEDQETMETIS	TRMT6	311	Q9UJA5
MTVNDSQPEDEDLNV	ZFX	301	P17010
QSQPEMSVQEAETVT	TRAV38-2DV8	26	A0JD32
MQVEIESDELPQTAE	ZNF236	796	Q9UL36
ESQRSESPMQEIVTD	ZC3H12C	226	Q9C0D7
SLDQALPEMSEEVNT	ZNF142	651	P52746
IAEEQMENEPQFSAI	XPO6	966	Q96QU8
TELQNMTVPEDDNIS	SLC38A1	11	Q9H2H9
VISEQSEQSVAVMPE	SON	221	P18583
MELTEQPVTTTELEQ	SON	501	P18583
QLIDPSDIDESSVMQ	USP13	646	Q92995
QSQPEMSVQEAETVT	TRAV38-1	26	A0A0B4J264
TQELQDPTQEDLEML	NLRP13	111	Q86W25
VSMHEVNTEVTENDP	SLC8A1	391	P32418