Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmyosin binding

USH2A ADGRV1

7.88e-0485102GO:0017022
GeneOntologyMolecularFunctionmodification-dependent protein binding

PRPF8 CARM1

4.51e-03206102GO:0140030
GeneOntologyMolecularFunctioncalcium ion binding

SVEP1 ADGRV1 AOC3

5.18e-03749103GO:0005509
GeneOntologyBiologicalProcessmaintenance of animal organ identity

USH2A ADGRV1

2.11e-065102GO:0048496
GeneOntologyBiologicalProcessphotoreceptor cell maintenance

USH2A ADGRV1

2.26e-0447102GO:0045494
GeneOntologyBiologicalProcessretina homeostasis

USH2A ADGRV1

4.20e-0464102GO:0001895
GeneOntologyCellularComponentUSH2 complex

USH2A ADGRV1

1.24e-064102GO:1990696
GeneOntologyCellularComponentstereocilium membrane

USH2A ADGRV1

3.09e-066102GO:0060171
GeneOntologyCellularComponentstereocilia ankle link

USH2A ADGRV1

3.09e-066102GO:0002141
GeneOntologyCellularComponentstereocilia ankle link complex

USH2A ADGRV1

3.09e-066102GO:0002142
GeneOntologyCellularComponentpericiliary membrane compartment

USH2A ADGRV1

3.09e-066102GO:1990075
GeneOntologyCellularComponentstereocilia coupling link

USH2A ADGRV1

5.76e-068102GO:0002139
GeneOntologyCellularComponentphotoreceptor connecting cilium

USH2A ADGRV1

2.30e-0448102GO:0032391
GeneOntologyCellularComponentactin-based cell projection

USH2A ADGRV1 AOC3

2.61e-04278103GO:0098858
GeneOntologyCellularComponentstereocilium

USH2A ADGRV1

4.75e-0469102GO:0032420
GeneOntologyCellularComponentphotoreceptor inner segment

USH2A ADGRV1

6.07e-0478102GO:0001917
GeneOntologyCellularComponentstereocilium bundle

USH2A ADGRV1

6.22e-0479102GO:0032421
GeneOntologyCellularComponentciliary transition zone

USH2A ADGRV1

6.54e-0481102GO:0035869
GeneOntologyCellularComponentneuron projection membrane

USH2A ADGRV1

6.70e-0482102GO:0032589
GeneOntologyCellularComponentbasement membrane

LAMA3 USH2A

1.47e-03122102GO:0005604
GeneOntologyCellularComponentphotoreceptor cell cilium

USH2A ADGRV1

1.91e-03139102GO:0097733
GeneOntologyCellularComponent9+0 non-motile cilium

USH2A ADGRV1

2.30e-03153102GO:0097731
GeneOntologyCellularComponentextracellular matrix

SVEP1 LAMA3 USH2A

3.13e-03656103GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

SVEP1 LAMA3 USH2A

3.16e-03658103GO:0030312
GeneOntologyCellularComponentciliary basal body

USH2A CILK1

3.71e-03195102GO:0036064
GeneOntologyCellularComponentnon-motile cilium

USH2A ADGRV1

3.75e-03196102GO:0097730
GeneOntologyCellularComponentleading edge membrane

USH2A ADGRV1

4.29e-03210102GO:0031256
GeneOntologyCellularComponentcluster of actin-based cell projections

USH2A ADGRV1

4.82e-03223102GO:0098862
GeneOntologyCellularComponentcilium

USH2A CILK1 ADGRV1

7.56e-03898103GO:0005929
GeneOntologyCellularComponentcell projection membrane

USH2A ADGRV1

1.71e-02431102GO:0031253
GeneOntologyCellularComponentcell leading edge

USH2A ADGRV1

2.26e-02500102GO:0031252
MousePhenoabnormal neck morphology

SVEP1 CILK1

4.81e-0515102MP:0012719
Domain-

SVEP1 LAMA3 USH2A ADGRV1

1.29e-07951042.60.120.200
DomainConA-like_dom

SVEP1 LAMA3 USH2A ADGRV1

3.65e-06219104IPR013320
DomainLAMININ_NTER

LAMA3 USH2A

3.08e-0516102PS51117
DomainLaminin_N

LAMA3 USH2A

3.08e-0516102PF00055
DomainLaminin_N

LAMA3 USH2A

3.08e-0516102IPR008211
DomainLamNT

LAMA3 USH2A

3.08e-0516102SM00136
DomainEGF_LAM_1

LAMA3 USH2A

1.11e-0430102PS01248
DomainEGF_LAM_2

LAMA3 USH2A

1.11e-0430102PS50027
DomainEGF_Lam

LAMA3 USH2A

1.52e-0435102SM00180
DomainLaminin_EGF

LAMA3 USH2A

1.52e-0435102PF00053
DomainLAM_G_DOMAIN

LAMA3 USH2A

1.80e-0438102PS50025
DomainLaminin_EGF

LAMA3 USH2A

1.80e-0438102IPR002049
DomainLaminin_G_2

LAMA3 USH2A

1.99e-0440102PF02210
DomainLamG

LAMA3 USH2A

2.41e-0444102SM00282
DomainEGF_1

SVEP1 LAMA3 USH2A

2.81e-04255103PS00022
DomainLaminin_G

LAMA3 USH2A

4.20e-0458102IPR001791
DomainGrowth_fac_rcpt_

SVEP1 LAMA3

2.99e-03156102IPR009030
DomainEGF

SVEP1 LAMA3

6.64e-03235102SM00181
DomainEGF-like_dom

SVEP1 LAMA3

7.42e-03249102IPR000742
DomainEGF-like_CS

SVEP1 LAMA3

8.13e-03261102IPR013032
DomainEGF_2

SVEP1 LAMA3

8.37e-03265102PS01186
Pubmed

Usher's Syndrome Type II: A Comparative Study of Genetic Mutations and Vestibular System Evaluation.

USH2A ADGRV1

7.44e-08210228653555
Pubmed

Characteristics of Retinitis Pigmentosa Associated with ADGRV1 and Comparison with USH2A in Patients from a Multicentric Usher Syndrome Study Treatrush.

USH2A ADGRV1

7.44e-08210234638692
Pubmed

Disease expression in Usher syndrome caused by VLGR1 gene mutation (USH2C) and comparison with USH2A phenotype.

USH2A ADGRV1

7.44e-08210215671307
Pubmed

The DFNB31 gene product whirlin connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1.

USH2A ADGRV1

2.23e-07310216434480
Pubmed

PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome.

USH2A ADGRV1

2.23e-07310220440071
Pubmed

Next-generation sequencing to solve complex inherited retinal dystrophy: A case series of multiple genes contributing to disease in extended families.

PRPF8 USH2A

2.23e-07310228761320
Pubmed

Targeted next generation sequencing in Italian patients with Usher syndrome: phenotype-genotype correlations.

USH2A ADGRV1

2.23e-07310229142287
Pubmed

Non-USH2A mutations in USH2 patients.

USH2A ADGRV1

2.23e-07310222147658
Pubmed

Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss.

USH2A ADGRV1

4.46e-07410220502675
Pubmed

Localization of PDZD7 to the stereocilia ankle-link associates this scaffolding protein with the Usher syndrome protein network.

USH2A ADGRV1

4.46e-07410223055499
Pubmed

Usher Syndrome Type II

USH2A ADGRV1

4.46e-07410220301515
Pubmed

Individual USH2 proteins make distinct contributions to the ankle link complex during development of the mouse cochlear stereociliary bundle.

USH2A ADGRV1

4.46e-07410226401052
Pubmed

Deafness-Associated ADGRV1 Mutation Impairs USH2A Stability through Improper Phosphorylation of WHRN and WDSUB1 Recruitment.

USH2A ADGRV1

4.46e-07410237066759
Pubmed

Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina.

USH2A ADGRV1

4.46e-07410237127773
Pubmed

Whirlin and PDZ domain-containing 7 (PDZD7) proteins are both required to form the quaternary protein complex associated with Usher syndrome type 2.

USH2A ADGRV1

4.46e-07410225406310
Pubmed

Usher syndromes due to MYO7A, PCDH15, USH2A or GPR98 mutations share retinal disease mechanism.

USH2A ADGRV1

4.46e-07410218463160
Pubmed

Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice.

USH2A ADGRV1

7.44e-07510224334608
Pubmed

Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2.

USH2A ADGRV1

7.44e-07510216301216
Pubmed

A novel Usher protein network at the periciliary reloading point between molecular transport machineries in vertebrate photoreceptor cells.

USH2A ADGRV1

7.44e-07510217906286
Pubmed

Biochemical characterization of native Usher protein complexes from a vesicular subfraction of tracheal epithelial cells.

USH2A ADGRV1

1.56e-06710220058854
Pubmed

Whirlin replacement restores the formation of the USH2 protein complex in whirlin knockout photoreceptors.

USH2A ADGRV1

1.56e-06710221212183
Pubmed

Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.

PRPF8 USH2A ADGRV1

1.79e-068710320801516
Pubmed

Microarray-based mutation analysis of 183 Spanish families with Usher syndrome.

USH2A ADGRV1

2.08e-06810219683999
Pubmed

Massively parallel DNA sequencing facilitates diagnosis of patients with Usher syndrome type 1.

USH2A ADGRV1

3.34e-061010224618850
Pubmed

Usher protein functions in hair cells and photoreceptors.

USH2A ADGRV1

3.34e-061010224239741
Pubmed

Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.

USH2A ADGRV1

8.91e-061610217567809
Pubmed

A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.

PRPF8 CARM1 ADAD1

1.12e-0434710316033648
Pubmed

Nonsyndromic Retinitis Pigmentosa Overview

PRPF8 USH2A

2.38e-048110220301590
GeneFamilyFibronectin type III domain containing|USH2 complex

USH2A ADGRV1

7.71e-074721244
CoexpressionNABA_ECM_GLYCOPROTEINS

SVEP1 LAMA3 USH2A

4.75e-05196103M3008
CoexpressionGSE33292_DN3_THYMOCYTE_VS_TCELL_LYMPHOMA_FROM_TCF1_KO_DN

ARHGAP11A SVEP1 CILK1

4.97e-05199103M9423
CoexpressionNABA_BASEMENT_MEMBRANES

LAMA3 USH2A

1.01e-0440102M5887
CoexpressionNABA_CORE_MATRISOME

SVEP1 LAMA3 USH2A

1.30e-04275103M5884
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SVEP1 USH2A ADGRV1

5.20e-06160103c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SVEP1 USH2A ADGRV1

5.20e-0616010325c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L3-4_RORB_RPS3P6|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LAMA3 USH2A ADGRV1

8.04e-0618510310da5c2a92bfb3248d3f6f94a0933996326cf590
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LAMA3 USH2A ADGRV1

8.17e-0618610323b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellPCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ARHGAP11A LAMA3 ADGRV1

8.84e-0619110339220f4a345e328f7fa4fd462a0abeea821b3e02
ToppCellPCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ARHGAP11A LAMA3 ADGRV1

8.98e-0619210325378b5e4b0cea8415ff125783511fc25a56fc00
ToppCellPCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ARHGAP11A LAMA3 ADGRV1

9.26e-06194103c197e4acbff42a9f0410b6801c2bfcf6160aefc1
ToppCellPBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SVEP1 ADGRV1

3.45e-041261026cb89754010d64875e115da6c5805efac7a4a82d
ToppCellPBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SVEP1 ADGRV1

3.45e-0412610269b2525b92d1c7c35b21cc701f5fa52a9c1b94bb
ToppCellPBMC-Mild-Myeloid-Neutrophil-Neutrophil-Neu_0|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ADGRV1 AOC3

3.79e-0413210282f312a561d9fdd2ebc2c25926dfc2b333ff0a4f
ToppCellPBMC-Mild-Myeloid-Neutrophil-Neutrophil-Neu_0|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ADGRV1 AOC3

3.79e-04132102fe87cb22e13e17df29ad43327f1aa71361907582
ToppCellLPS_only-Endothelial-Endothelial-FOXM1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGAP11A ADAD1

3.90e-041341024d8f7ddad02fe76a614771e115ebb8e04623ba85
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USH2A ADGRV1

4.56e-0414510296712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellPND07-28-samps-Mesenchymal-Pericyte|PND07-28-samps / Age Group, Lineage, Cell class and subclass

CARM1 AOC3

4.88e-041501025b111ec11a642d63fafa7e1422e36f81a2776531
ToppCellPND07-28-samps-Mesenchymal-Pericyte-pericyte_F|PND07-28-samps / Age Group, Lineage, Cell class and subclass

CARM1 AOC3

4.88e-041501022d0d6dc07dcfe28e3d7694c52d15d17dae2fd47b
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-7|TCGA-Liver / Sample_Type by Project: Shred V9

LAMA3 CILK1

5.48e-0415910270288df54adab167c0f50675128619299077db11
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

USH2A ADGRV1

5.69e-04162102bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SVEP1 AOC3

5.83e-0416410201a7c335897128d3478b8b9b44fb461cab493084
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

LAMA3 AOC3

5.97e-04166102f416d8a322f086c769659a9fab6b460a2d546ab1
ToppCellPCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

LAMA3 ADGRV1

6.04e-0416710225af48c640e67848594f5902867ba325fc105da4
ToppCellControl|World / group, cell type (main and fine annotations)

LAMA3 ADGRV1

6.12e-04168102a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-4_VIP_CHRNA2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SVEP1 LAMA3

6.12e-0416810211ab08e373abe4bbd0f2134db38a2e8efa0eb159
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|343B / Donor, Lineage, Cell class and subclass (all cells)

ARHGAP11A LAMA3

6.19e-04169102a949f547b53126a208819bade74a1ac9b2a36ea7
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|343B / Donor, Lineage, Cell class and subclass (all cells)

ARHGAP11A LAMA3

6.19e-04169102195d5cd60d646ac6d40a3321b2f739917e7aef14
ToppCelldroplet-Liver-LIVER_NPC-30m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SVEP1 AOC3

6.19e-04169102c5015ddb838849ea892a2cae5a739b554eb6d793
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USH2A ADGRV1

6.19e-0416910212bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SVEP1 ADGRV1

6.26e-04170102ba4ba66b624089ed50a9083176386c7941b4c7a3
ToppCellControl-Epithelial_cells-ECM-high_epithelial|Control / group, cell type (main and fine annotations)

LAMA3 ADGRV1

6.26e-04170102e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-4_VIP_CHRNA2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SVEP1 LAMA3

6.26e-0417010228e22f9ef58423acc0fb8de1aff958b116dd33e9
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SVEP1 LAMA3

6.33e-04171102a5634b76476b8b2488a706bbab5141f7bd94631f
ToppCelldroplet-Liver-LIVER_NPC-30m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SVEP1 AOC3

6.33e-0417110220ac3de9c164b409b70a30a8b6544ea491ef7c0e
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SVEP1 LAMA3

6.41e-041721028b396d1e9173da104d467e42286379fe07cee257
ToppCell15-Trachea-Mesenchymal-Mesenchyme_RSPO2+|Trachea / Age, Tissue, Lineage and Cell class

ARHGAP11A CARM1

6.56e-04174102fa0681e91724b9a51ee28b214ea5aa14e62ba1a3
ToppCellTCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue-Breast_normal_tissue-3|TCGA-Breast / Sample_Type by Project: Shred V9

SVEP1 AOC3

6.56e-041741027f8f5fafae08676d2b90cab9802c3c9320f1370e
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)-|367C / Donor, Lineage, Cell class and subclass (all cells)

LAMA3 ADGRV1

6.56e-04174102edf839d79ac58921f4e788f3b2cb2ae0d6af4b9e
ToppCellwk_15-18-Epithelial-Distal_epithelial-type_I_pneumocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

LAMA3 ADGRV1

6.56e-041741022cd6638b361ca05ab83d09ce657194aed97873b7
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGAP11A AOC3

6.56e-0417410241eb0a214a8b4015a26311f77061c8147144f0e7
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)|367C / Donor, Lineage, Cell class and subclass (all cells)

LAMA3 ADGRV1

6.56e-0417410265539f69100db0b7d90b1b39ee15ab8281f86461
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SVEP1 LAMA3

6.63e-041751029d09636a103daa8f622c3dbfd1f1536aaec3b6bb
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SVEP1 LAMA3

6.63e-04175102e78bf0c33a741bb97e987e41ac33da9e623a08ec
ToppCellfacs-Marrow-B-cells-24m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USH2A ADGRV1

6.63e-04175102887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SVEP1 ADAD1

6.63e-04175102795a6564d5a75ffd35d39f5274b9e8d28708bbc8
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|368C / Donor, Lineage, Cell class and subclass (all cells)

ARHGAP11A ADGRV1

6.63e-04175102fd8b5b756f3df4a04938785f3d9edbb6f1cd20f6
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|368C / Donor, Lineage, Cell class and subclass (all cells)

ARHGAP11A ADGRV1

6.63e-0417510236c140540497bbe1c5f08fac2d94f08cac18fabb
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SVEP1 LAMA3

6.71e-041761020fb6b57c3fffc93c40f4989007af4d522666c5e9
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USH2A ADGRV1

6.71e-04176102c6484334187f64cd00cd35e77d8ae436556b4260
ToppCellLPS-IL1RA+antiTNF|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SVEP1 LAMA3

6.78e-04177102b7fee75de7e96924af488a5baa2334711889ae7c
ToppCell356C-Fibroblasts-Fibroblast-G-|356C / Donor, Lineage, Cell class and subclass (all cells)

SVEP1 AOC3

6.78e-041771027617270f49cd6b7ba66db72d20560cee985012b2
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SVEP1 LAMA3

6.78e-04177102d7976eac7e27044f6a859cc0c3398d08576e8c01
ToppCell356C-Fibroblasts-Fibroblast-G|356C / Donor, Lineage, Cell class and subclass (all cells)

SVEP1 AOC3

6.78e-041771028220cc2fc0ee8764a67a3be51d75248be2453040
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SVEP1 AOC3

6.86e-0417810209475e522dc1b8cf9ff1c25de5d1e3082b162948
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SVEP1 LAMA3

6.86e-041781022a36475c260088f69f3b8c282d910e5eaa5c5c2d
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SVEP1 AOC3

6.86e-0417810235de8f791b0e78a6caf52ff095f05e204a59e828
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SVEP1 AOC3

6.86e-04178102000d25f3f13cc76cf39c46c312c6fafc2ea4f368
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6|TCGA-Ovary / Sample_Type by Project: Shred V9

SVEP1 AOC3

6.86e-04178102142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

LAMA3 ADGRV1

6.94e-04179102cb38b54261a7af5ee3347e64c8aa880a77ed0763
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SVEP1 LAMA3

6.94e-04179102cd7f0e8f4abb2a2bac366c8910c8c5fda841dbce
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP11A LAMA3

6.94e-0417910288d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LAMA3 ADGRV1

6.94e-04179102fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCellCOVID-19-Heart-VSMC|Heart / Disease (COVID-19 only), tissue and cell type

LAMA3 AOC3

6.94e-04179102a69ad6912b5c10bb9f9d800f724c792341e9bab1
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SVEP1 LAMA3

6.94e-0417910201302505816f272243659e20d751b61a198a2fc0
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SVEP1 LAMA3

6.94e-04179102ac94d4c32402c9b856fab656ac1aff0ee12d152c
ToppCellCOVID-19-Epithelial_cells-AT1|COVID-19 / group, cell type (main and fine annotations)

LAMA3 ADGRV1

6.94e-04179102a0b33bd69ffdfd5d38d80207fb40058a490aa19e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SVEP1 AOC3

7.01e-04180102ea7a1ccf0dd3bb5af5df87501f873e7339a824b3
ToppCell390C-Fibroblasts-Fibroblast-G|390C / Donor, Lineage, Cell class and subclass (all cells)

SVEP1 AOC3

7.01e-04180102137fc14859c89e1ecd98bee388bb58c04b835847
ToppCellfacs-Kidney-nan-24m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SVEP1 AOC3

7.01e-04180102f9f8245cbcdea18c15e2976c85b72c6807309787
ToppCell390C-Fibroblasts-Fibroblast-G-|390C / Donor, Lineage, Cell class and subclass (all cells)

SVEP1 AOC3

7.01e-04180102cd6790de050151fedfa2c5ea6ad58b72665414b2
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SVEP1 LAMA3

7.01e-04180102c6030e725e3d86d5d74a1676330c77ffeceb324f
ToppCell5'-GW_trimst-2-LymphNode-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMA3 AOC3

7.09e-0418110259527ad218e49386b04cabb97d53d2ed55a35961
ToppCelltumor_Lung-Fibroblasts-Undetermined|tumor_Lung / Location, Cell class and cell subclass

SVEP1 AOC3

7.09e-0418110253bcab4d6df4a3255d81877ba22fb95d4492ce9f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SVEP1 LAMA3

7.09e-041811026c55985e464cb0f5fb3362e9fd90351b671950f7
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SVEP1 LAMA3

7.17e-04182102724c33ad2fb525cbcfa5efa3362675eb42a5636d
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SVEP1 LAMA3

7.17e-04182102d3a037268f026eb2f84428b1821022503cef7756
ToppCellCOVID-19-lung-AT1|lung / Disease (COVID-19 only), tissue and cell type

LAMA3 ADGRV1

7.25e-04183102942530449e9c6583705eeb8f6f12621daea57252
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

LAMA3 ADGRV1

7.25e-041831026847c1252d6bb105524f812658112517fd351eab
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-cycling_ENCC/glia|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARHGAP11A ADGRV1

7.25e-0418310229b62dd542bc3f8df843998f577724f3818d4271
ToppCellCOVID-19-lung-AT1|COVID-19 / Disease (COVID-19 only), tissue and cell type

LAMA3 ADGRV1

7.25e-041831027b1a385ed54f93bfe85bf0c162e42d05d516b45c
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

USH2A ADGRV1

7.25e-04183102d73cac83cde82665f110baad7cf28db75f9ffe52
ToppCellCOVID-19-Epithelial_cells-ECM-high_epithelial|COVID-19 / group, cell type (main and fine annotations)

LAMA3 ADGRV1

7.25e-04183102dc1d380bf7564f290256cb7108063d1bd2da732b
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USH2A ADGRV1

7.33e-04184102ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGAP11A AOC3

7.33e-04184102d1e0e3b0eed2db8a5b7e3d6f81294667e4ba64e5
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USH2A ADGRV1

7.33e-041841022cbed6462fea2622871bb7e49b0df3d984239281
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SVEP1 LAMA3

7.33e-0418410232473dbdb2de66391157c5814ef34e790806e4f2
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USH2A ADGRV1

7.33e-041841022b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellPCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

LAMA3 ADGRV1

7.33e-04184102fa4915b0498f3069fd5ef497286445528f75187e
ToppCellControl-Epithelial_alveolar-AT_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LAMA3 ADGRV1

7.33e-0418410251e129b3fcc2df083eda05a3afe3717218b1e52b
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMA3 AOC3

7.41e-0418510235d39a1d04c871edcfb749653538dc5fd0054281
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SVEP1 LAMA3

7.41e-04185102cefd81adb480c027545a5c78dcd05669783717f4
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LAMA3 ADGRV1

7.41e-041851020d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP11A LAMA3

7.41e-0418510230e041d6f6e310d64809e9d6d93cd30052972f3b
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SVEP1 LAMA3

7.41e-041851020b5a0df58ae2ad8261f40f152775747af4f3937a
ToppCell5'-GW_trimst-2-LymphNode-Mesenchymal-Pericytes|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMA3 AOC3

7.48e-041861021e3ab663e4756975db6d802b2c6c054a94a79393
ToppCell(2)_Fibroblasts-(20)_Fibro-1|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis

SVEP1 AOC3

7.48e-04186102e93415b59dd89bc8a966dab0e0b65fe215933598
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LAMA3 ADGRV1

7.48e-04186102e83718fabb057100835d3357df407f283d23fe16
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SVEP1 AOC3

7.48e-041861025473283fb95cee556b1f6934cf72169b676b5bcc
ToppCellPCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

LAMA3 ADGRV1

7.48e-04186102bb0bfe9a015151be08a6ffc5d82896d0556d76de
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP11A SVEP1

7.56e-04187102cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SVEP1 LAMA3

7.56e-04187102eb011a3d8a3025cebb0fba36d403be906305372c
ToppCellPCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

LAMA3 ADGRV1

7.56e-04187102db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCellmetastatic_Lymph_Node-Fibroblasts-COL13A1+_matrix_FBs|metastatic_Lymph_Node / Location, Cell class and cell subclass

SVEP1 AOC3

7.56e-04187102e04fb35f2f5b120659d06b5ae427ab1ec56d5c36
Drugazidopine

CILK1 AOC3

6.52e-0528102CID000656406
DrugPrazosin hydrochloride [19237-84-4]; Down 200; 9.6uM; MCF7; HT_HG-U133A

ARHGAP11A SVEP1 CILK1

7.54e-051991036475_DN
Drug3-mercaptopropionic acid

ADGRV1 AOC3

1.63e-0444102CID000006514
Drugphenethanolamine

ADGRV1 AOC3

1.78e-0446102CID000001000
Drugifenprodil

ADGRV1 AOC3

4.25e-0471102CID000003689
Drugsodium bicarbonate

ADGRV1 AOC3

4.61e-0474102CID000010340
Drugbu-b

USH2A ADGRV1

4.99e-0477102CID000351065
Drugphenylethylamine

ADGRV1 AOC3

6.66e-0489102CID000001001
Drugtranylcypromine

LAMA3 AOC3

6.96e-0491102CID000005530
Drug2-nitroimidazole

ARHGAP11A USH2A

1.39e-03129102CID000010701
DrugMifepristone

SVEP1 LAMA3 AOC3

1.51e-03553103ctd:D015735
Drugpyridoxal

CILK1 AOC3

1.52e-03135102CID000001050
Drugoltipraz

ADGRV1 AOC3

1.57e-03137102CID000047318
DrugAC1Q5UBL

ADGRV1 AOC3

1.78e-03146102CID000005466
DrugNexus

CARM1 CILK1

1.92e-03152102CID000098527
Diseaseretinitis pigmentosa (implicated_via_orthology)

PRPF8 USH2A

3.61e-0527102DOID:10584 (implicated_via_orthology)
DiseaseDisorder of eye

PRPF8 USH2A ADGRV1

4.23e-05212103C0015397
Diseaseretinitis pigmentosa (is_implicated_in)

PRPF8 USH2A

8.42e-0541102DOID:10584 (is_implicated_in)
DiseaseRetinitis pigmentosa

PRPF8 USH2A

2.76e-0474102cv:C0035334
Diseasehearing impairment

USH2A ADGRV1

4.83e-0498102C1384666
DiseaseRetinitis Pigmentosa

PRPF8 USH2A

5.44e-04104102C0035334
DiseaseCiliopathies

USH2A ADGRV1

6.08e-04110102C4277690
Diseaseallergic rhinitis

LAMA3 ADAD1

8.86e-04133102EFO_0005854
Diseasecomplement factor H-related protein 3 measurement

USH2A ADGRV1

1.42e-03169102EFO_0600056
Diseaseovarian carcinoma

LAMA3 ADGRV1

5.01e-03321102EFO_0001075

Protein segments in the cluster

PeptideGeneStartEntry
TFSAWVMPNANTNGF

ADGRV1

1356

Q8WXG9
MASNNHWFQSSQVPS

ADAD1

1

Q96M93
PQNSSMARGFSWERY

AOC3

616

Q16853
FSWRGYAQMTSVQND

LAMA3

756

Q16787
SSVSFYNWMSNAVGN

KIAA1109

2346

Q2LD37
SPSENMWNTGSTYNL

CARM1

491

Q86X55
NTFMYNDTGLQPWTQ

USH2A

4221

O75445
NYRMSWTGPNNSSFQ

ARHGAP11A

516

Q6P4F7
SGWATFQQMSPSRNF

SVEP1

16

Q4LDE5
EGYQLSSAMNFRWPQ

CILK1

226

Q9UPZ9
QSSWNYNFMGVRHDP

PRPF8

2276

Q6P2Q9