Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF750 ZNF845 ZNF526 ZNF320 ZBTB38 ZBTB39 ZSCAN20 MYOD1 ZNF875 ZNF596 SP9 DMRTA2 ZNF853 SKI ZNF865 ZNF501 ZKSCAN5 ZNF786 ZNF697 ZNF646	5.96e-08	1459	69	20	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF750 ZNF845 ZNF526 ZNF320 ZBTB38 ZBTB39 ZSCAN20 MYOD1 SP9 DMRTA2 ZNF853 SKI ZNF865 ZNF501 ZKSCAN5 ZNF786 ZNF697 ZNF646	1.46e-07	1244	69	18	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF750 ZNF845 ZNF526 ZNF320 ZBTB38 ZBTB39 ZSCAN20 MYOD1 SP9 DMRTA2 ZNF853 SKI ZNF865 ZNF501 ZKSCAN5 ZNF786 ZNF697 ZNF646	2.01e-07	1271	69	18	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF750 ZNF845 ZNF526 ZNF320 ZBTB38 ZBTB39 ZSCAN20 MYOD1 ZNF875 ZNF596 SP9 DMRTA2 ZNF853 SKI ZKSCAN5 ZNF786 ZNF697 ZNF646	9.40e-07	1412	69	18	GO:0000981
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	GLUD1 GLUD2	1.18e-05	2	69	2	GO:0016639
GeneOntologyMolecularFunction	glutamate dehydrogenase [NAD(P)+] activity	GLUD1 GLUD2	1.18e-05	2	69	2	GO:0004353
GeneOntologyMolecularFunction	glutamate dehydrogenase (NAD+) activity	GLUD1 GLUD2	1.18e-05	2	69	2	GO:0004352
GeneOntologyMolecularFunction	glutamate dehydrogenase (NADP+) activity	GLUD1 GLUD2	1.18e-05	2	69	2	GO:0004354
GeneOntologyMolecularFunction	steroid 11-beta-monooxygenase activity	CYP11B1 CYP11B2	1.18e-05	2	69	2	GO:0004507
GeneOntologyMolecularFunction	corticosterone 18-monooxygenase activity	CYP11B1 CYP11B2	1.18e-05	2	69	2	GO:0047783
GeneOntologyMolecularFunction	L-leucine binding	GLUD1 GLUD2	2.44e-04	7	69	2	GO:0070728
GeneOntologyMolecularFunction	transition metal ion binding	AARS2 ZNF875 RPTN CYP11B1 CYP11B2 TUT1 SKI ZKSCAN5 ZCCHC3 WDFY1 AGBL3 LARGE1	7.06e-04	1189	69	12	GO:0046914
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP11B1 CYP11B2	8.96e-04	13	69	2	GO:0016713
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH2 group of donors	GLUD1 GLUD2	2.15e-03	20	69	2	GO:0016638
GeneOntologyMolecularFunction	NAD+ binding	GLUD1 GLUD2	2.15e-03	20	69	2	GO:0070403
MousePheno	abnormal urine progesterone level	CYP11B1 CYP11B2	1.06e-05	2	46	2	MP:0011545
MousePheno	abnormal urine deoxycorticosterone level	CYP11B1 CYP11B2	1.06e-05	2	46	2	MP:0011552
MousePheno	decreased urine corticosterone level	CYP11B1 CYP11B2	1.06e-05	2	46	2	MP:0011550
MousePheno	increased urine deoxycorticosterone level	CYP11B1 CYP11B2	1.06e-05	2	46	2	MP:0011553
MousePheno	increased urine progesterone level	CYP11B1 CYP11B2	1.06e-05	2	46	2	MP:0011546
MousePheno	abnormal adrenal gland zona glomerulosa morphology	CYP11B1 CYP11B2	6.33e-05	4	46	2	MP:0008293
MousePheno	decreased urine aldosterone level	CYP11B1 CYP11B2	6.33e-05	4	46	2	MP:0011541
MousePheno	abnormal urine aldosterone level	CYP11B1 CYP11B2	6.33e-05	4	46	2	MP:0011539
MousePheno	abnormal urine corticosterone level	CYP11B1 CYP11B2	6.33e-05	4	46	2	MP:0011548
MousePheno	decreased urine hormone level	CYP11B1 CYP11B2	6.33e-05	4	46	2	MP:0014459
MousePheno	increased adrenal gland zona fasciculata size	CYP11B1 CYP11B2	1.05e-04	5	46	2	MP:0014286
MousePheno	uterus adenomyosis	CYP11B1 CYP11B2	1.58e-04	6	46	2	MP:0009221
MousePheno	increased urine hormone level	CYP11B1 CYP11B2	1.58e-04	6	46	2	MP:0014458
MousePheno	adrenal gland hyperplasia	CYP11B1 CYP11B2	1.58e-04	6	46	2	MP:0009078
MousePheno	abnormal urine hormone level	CYP11B1 CYP11B2	2.20e-04	7	46	2	MP:0011538
MousePheno	pituitary gland hyperplasia	CYP11B1 CYP11B2	2.20e-04	7	46	2	MP:0000635
MousePheno	increased enzyme/coenzyme level	DCAF15 EDC3 EXPH5 PRF1 CYP11B1 CYP11B2 MTMR3 OCIAD2 C10orf90 HERC1 KLRC1 PLEKHM1	2.50e-04	1148	46	12	MP:0014448
MousePheno	increased circulating angiotensin II level	CYP11B1 CYP11B2	2.93e-04	8	46	2	MP:0031232
MousePheno	increased angiotensin II level	CYP11B1 CYP11B2	2.93e-04	8	46	2	MP:0031229
MousePheno	decreased circulating renin level	CYP11B1 CYP11B2	4.69e-04	10	46	2	MP:0003353
MousePheno	abnormal adrenocortical cell morphology	CYP11B1 CYP11B2	4.69e-04	10	46	2	MP:0008291
MousePheno	decreased insulin secretion	TGFBI GLUD1 GLUD2 RNF213	4.75e-04	111	46	4	MP:0003059
MousePheno	abnormal adrenal gland zona fasciculata size	CYP11B1 CYP11B2	5.72e-04	11	46	2	MP:0014284
MousePheno	uterus cyst	CYP11B1 CYP11B2	5.72e-04	11	46	2	MP:0009082
MousePheno	abnormal enzyme/coenzyme level	ZNF750 DCAF15 EDC3 EXPH5 PRF1 CYP11B1 CYP11B2 MTMR3 OCIAD2 C10orf90 HERC1 KLRC1 PLEKHM1	5.89e-04	1451	46	13	MP:0005319
MousePheno	abnormal circulating angiotensin II level	CYP11B1 CYP11B2	6.85e-04	12	46	2	MP:0031230
MousePheno	abnormal angiotensin II level	CYP11B1 CYP11B2	6.85e-04	12	46	2	MP:0031227
MousePheno	hypokalemia	CYP11B1 CYP11B2	6.85e-04	12	46	2	MP:0004119
MousePheno	enlarged pituitary gland	CYP11B1 CYP11B2	6.85e-04	12	46	2	MP:0000636
MousePheno	decreased circulating potassium level	EXPH5 CYP11B1 CYP11B2	7.35e-04	54	46	3	MP:0005628
MousePheno	increased renin activity	CYP11B1 CYP11B2	9.40e-04	14	46	2	MP:0005582
MousePheno	decreased circulating mineralocorticoid level	CYP11B1 CYP11B2	9.40e-04	14	46	2	MP:0003374
MousePheno	increased urine osmolality	CYP11B1 CYP11B2	9.40e-04	14	46	2	MP:0008055
MousePheno	increased type II pneumocyte number	LIPA BMPER	9.40e-04	14	46	2	MP:0010810
MousePheno	increased circulating adrenocorticotropin level	CYP11B1 CYP11B2	9.40e-04	14	46	2	MP:0001748
MousePheno	decreased circulating aldosterone level	CYP11B1 CYP11B2	9.40e-04	14	46	2	MP:0002667
MousePheno	endometrium hyperplasia	CYP11B1 CYP11B2	9.40e-04	14	46	2	MP:0009092
MousePheno	increased circulating enzyme level	DCAF15 EDC3 PRF1 CYP11B1 CYP11B2 MTMR3 OCIAD2 C10orf90 HERC1 KLRC1 PLEKHM1	9.40e-04	1140	46	11	MP:0014450
Domain	Znf_C2H2	ZNF750 ZNF845 ZNF526 ZNF320 ZBTB38 ZBTB39 ZSCAN20 ZNF875 ZNF596 SP9 TUT1 ZNF853 ZNF865 ZNF501 ZKSCAN5 ZNF786 ZNF697 ZNF646	3.65e-10	805	68	18	IPR007087
Domain	ZnF_C2H2	ZNF750 ZNF845 ZNF526 ZNF320 ZBTB38 ZBTB39 ZSCAN20 ZNF875 ZNF596 SP9 TUT1 ZNF853 ZNF865 ZNF501 ZKSCAN5 ZNF786 ZNF697 ZNF646	3.88e-10	808	68	18	SM00355
Domain	-	ZNF845 ZNF526 ZNF320 ZBTB38 ZBTB39 ZSCAN20 ZNF875 ZNF596 SP9 ZNF853 ZNF865 ZNF501 ZKSCAN5 ZNF786 ZNF697 ZNF646	1.97e-09	679	68	16	3.30.160.60
Domain	Znf_C2H2-like	ZNF750 ZNF845 ZNF526 ZNF320 ZBTB38 ZBTB39 ZSCAN20 ZNF875 ZNF596 SP9 ZNF853 ZNF865 ZNF501 ZKSCAN5 ZNF786 ZNF697 ZNF646	2.49e-09	796	68	17	IPR015880
Domain	zf-C2H2	ZNF845 ZNF526 ZNF320 ZBTB38 ZBTB39 ZSCAN20 ZNF875 ZNF596 SP9 ZNF853 ZNF865 ZNF501 ZKSCAN5 ZNF786 ZNF697 ZNF646	2.64e-09	693	68	16	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF845 ZNF526 ZNF320 ZBTB38 ZBTB39 ZSCAN20 ZNF875 ZNF596 SP9 ZNF853 ZNF865 ZNF501 ZKSCAN5 ZNF786 ZNF697 ZNF646	2.70e-09	694	68	16	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF845 ZNF526 ZNF320 ZBTB38 ZBTB39 ZSCAN20 ZNF875 ZNF596 SP9 ZNF853 ZNF865 ZNF501 ZKSCAN5 ZNF786 ZNF697 ZNF646	1.29e-08	775	68	16	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF845 ZNF526 ZNF320 ZBTB38 ZBTB39 ZSCAN20 ZNF875 ZNF596 SP9 ZNF853 ZNF865 ZNF501 ZKSCAN5 ZNF786 ZNF697 ZNF646	1.34e-08	777	68	16	PS00028
Domain	ELFV_dehydrog_N	GLUD1 GLUD2	1.31e-05	2	68	2	PF02812
Domain	Glu/Leu/Phe/Val_DH_C	GLUD1 GLUD2	1.31e-05	2	68	2	IPR006096
Domain	Glu/Leu/Phe/Val_DH_dimer_dom	GLUD1 GLUD2	1.31e-05	2	68	2	IPR006097
Domain	Glu/Leu/Phe/Val_DH	GLUD1 GLUD2	1.31e-05	2	68	2	IPR006095
Domain	ELFV_dehydrog	GLUD1 GLUD2	1.31e-05	2	68	2	PF00208
Domain	ELFV_dehydrog	GLUD1 GLUD2	1.31e-05	2	68	2	SM00839
Domain	Glu/Leu/Phe/Val_DH_AS	GLUD1 GLUD2	1.31e-05	2	68	2	IPR033524
Domain	NAD_bind_Glu_DH	GLUD1 GLUD2	1.31e-05	2	68	2	IPR033922
Domain	Cyt_P450_mitochondrial	CYP11B1 CYP11B2	1.31e-05	2	68	2	IPR002399
Domain	GLFV_DEHYDROGENASE	GLUD1 GLUD2	1.31e-05	2	68	2	PS00074
Domain	zf-C2H2_6	ZNF845 ZNF526 ZNF320 ZNF865 ZNF501 ZKSCAN5 ZNF646	1.43e-04	314	68	7	PF13912
Domain	KRAB	ZNF845 ZNF320 ZSCAN20 ZNF875 ZNF596 ZKSCAN5 ZNF786	3.82e-04	369	68	7	SM00349
Domain	KRAB	ZNF845 ZNF320 ZSCAN20 ZNF875 ZNF596 ZKSCAN5 ZNF786	3.88e-04	370	68	7	IPR001909
Domain	EMI_domain	TGFBI MEGF6	1.52e-03	16	68	2	IPR011489
Domain	EMI	TGFBI MEGF6	1.71e-03	17	68	2	PS51041
Domain	KRAB	ZNF845 ZNF320 ZNF875 ZNF596 ZKSCAN5 ZNF786	1.92e-03	358	68	6	PS50805
Domain	KRAB	ZNF845 ZNF320 ZNF875 ZNF596 ZKSCAN5 ZNF786	1.92e-03	358	68	6	PF01352
Domain	FYVE	MTMR3 WDFY1	4.98e-03	29	68	2	PF01363
Domain	FYVE	MTMR3 WDFY1	4.98e-03	29	68	2	SM00064
Pathway	KEGG_MEDICUS_REFERENCE_STEROID_HORMONE_BIOSYNTHESIS_PROGESTERONE_TO_CORTISOL_CORTISONE	CYP11B1 CYP11B2	9.90e-05	5	45	2	M47522
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	4.41e-04	10	45	2	M27076
Pathway	REACTOME_TRANSCRIPTIONAL_ACTIVATION_OF_MITOCHONDRIAL_BIOGENESIS	GLUD1 GLUD2	5.38e-04	11	45	2	MM14866
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	5.38e-04	11	45	2	MM14750
Pathway	REACTOME_MINERALOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	6.44e-04	12	45	2	MM14749
Pathway	REACTOME_TRANSCRIPTIONAL_ACTIVATION_OF_MITOCHONDRIAL_BIOGENESIS	GLUD1 GLUD2 TFB2M	7.10e-04	55	45	3	M27145
Pathway	WP_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	8.85e-04	14	45	2	M46449
Pathway	REACTOME_GLUTAMATE_AND_GLUTAMINE_METABOLISM	GLUD1 GLUD2	8.85e-04	14	45	2	M27851
Pathway	WP_MINERALOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	8.85e-04	14	45	2	M46453
Pathway	REACTOME_GLUTAMATE_AND_GLUTAMINE_METABOLISM	GLUD1 GLUD2	8.85e-04	14	45	2	MM15570
Pathway	REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE	EDC3 XRN1	1.02e-03	15	45	2	M11063
Pathway	WP_CLASSICAL_PATHWAY_OF_STEROIDOGENESIS_WITH_GLUCOCORTICOID_AND_MINERALOCORTICOID_METABOLISM	CYP11B1 CYP11B2	1.16e-03	16	45	2	M39815
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ARHGAP32 ZNF526 ZBTB39 AARS2 MEGF6 EXPH5 RNF213 ALPK1 ZKSCAN5	1.05e-06	493	74	9	15368895
Pubmed	Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis.	SEMA3C GLUD1 GLUD2	2.60e-06	13	74	3	15609325
Pubmed	Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.	CYP11B1 CYP11B2	4.47e-06	2	74	2	17651452
Pubmed	Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.	CYP11B1 CYP11B2	4.47e-06	2	74	2	23150505
Pubmed	Expression of CYP11B1 and CYP11B2 in adrenal adenoma correlates with clinical characteristics of primary aldosteronism.	CYP11B1 CYP11B2	4.47e-06	2	74	2	34743356
Pubmed	GRAde: a long-read sequencing approach to efficiently identifying the CYP11B1/CYP11B2 chimeric form in patients with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	4.47e-06	2	74	2	35012455
Pubmed	Role of genetic variation in regulation of aldosterone biosynthesis.	CYP11B1 CYP11B2	4.47e-06	2	74	2	21164264
Pubmed	Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	4.47e-06	2	74	2	2783417
Pubmed	Critical role of the cysteine 323 residue in the catalytic activity of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	4.47e-06	2	74	2	15750346
Pubmed	Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum.	GLUD1 GLUD2	4.47e-06	2	74	2	21446915
Pubmed	Molecular cloning, structure and expression analysis of a full-length mouse brain glutamate dehydrogenase cDNA.	GLUD1 GLUD2	4.47e-06	2	74	2	1711373
Pubmed	Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors.	GLUD1 GLUD2	4.47e-06	2	74	2	34173171
Pubmed	Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.	GLUD1 GLUD2	4.47e-06	2	74	2	28621566
Pubmed	Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.	CYP11B1 CYP11B2	4.47e-06	2	74	2	2256920
Pubmed	Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism.	CYP11B1 CYP11B2	4.47e-06	2	74	2	20339375
Pubmed	Editorial: polymorphisms in CYP11B genes and 11-hydroxylase activity.	CYP11B1 CYP11B2	4.47e-06	2	74	2	15699546
Pubmed	Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection.	GLUD1 GLUD2	4.47e-06	2	74	2	18688271
Pubmed	Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway.	CYP11B1 CYP11B2	4.47e-06	2	74	2	18162527
Pubmed	Chronic activation of adrenal Gq signaling induces Cyp11b2 expression in the zona fasciculata and hyperaldosteronism.	CYP11B1 CYP11B2	4.47e-06	2	74	2	38341019
Pubmed	The complex regulation of human glud1 and glud2 glutamate dehydrogenases and its implications in nerve tissue biology.	GLUD1 GLUD2	4.47e-06	2	74	2	22658952
Pubmed	GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior.	GLUD1 GLUD2	4.47e-06	2	74	2	32078638
Pubmed	Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate.	GLUD1 GLUD2	4.47e-06	2	74	2	20529287
Pubmed	Association of DNA polymorphisms within the CYP11B2/CYP11B1 locus and postoperative hypertension risk in the patients with aldosterone-producing adenomas.	CYP11B1 CYP11B2	4.47e-06	2	74	2	20708777
Pubmed	Molecular genetic studies on the biosynthesis of aldosterone in humans.	CYP11B1 CYP11B2	4.47e-06	2	74	2	22217843
Pubmed	Genetic analyses of the chimeric CYP11B1/CYP11B2 gene in a Korean family with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	4.47e-06	2	74	2	20808686
Pubmed	Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation.	CYP11B1 CYP11B2	4.47e-06	2	74	2	16396990
Pubmed	Development of mice with brain-specific deletion of floxed glud1 (glutamate dehydrogenase 1) using cre recombinase driven by the nestin promoter.	GLUD1 GLUD2	4.47e-06	2	74	2	23595828
Pubmed	Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.	CYP11B1 CYP11B2	4.47e-06	2	74	2	24837548
Pubmed	Determination of glutamate dehydrogenase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry).	GLUD1 GLUD2	4.47e-06	2	74	2	25124006
Pubmed	The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity.	CYP11B1 CYP11B2	4.47e-06	2	74	2	8645611
Pubmed	Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity.	CYP11B1 CYP11B2	4.47e-06	2	74	2	30046010
Pubmed	GluD1 binds GABA and controls inhibitory plasticity.	GLUD1 GLUD2	4.47e-06	2	74	2	38060673
Pubmed	Familial and phenotypic associations of the aldosterone Renin ratio.	CYP11B1 CYP11B2	4.47e-06	2	74	2	19820005
Pubmed	Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice.	GLUD1 GLUD2	4.47e-06	2	74	2	24593767
Pubmed	[123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes.	CYP11B1 CYP11B2	4.47e-06	2	74	2	18397978
Pubmed	Unexpected histone H3 tail-clipping activity of glutamate dehydrogenase.	GLUD1 GLUD2	4.47e-06	2	74	2	23673664
Pubmed	Expression and localization of cytochrome P450(11beta,aldo) mRNA in the frog brain.	CYP11B1 CYP11B2	4.47e-06	2	74	2	12231255
Pubmed	Increases in anterograde axoplasmic transport in neurons of the hyper-glutamatergic, glutamate dehydrogenase 1 (Glud1) transgenic mouse: Effects of glutamate receptors on transport.	GLUD1 GLUD2	4.47e-06	2	74	2	38124277
Pubmed	Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.	CYP11B1 CYP11B2	4.47e-06	2	74	2	1518866
Pubmed	A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type I.	CYP11B1 CYP11B2	4.47e-06	2	74	2	20634641
Pubmed	Potentiation of neuronal activity by tonic GluD1 current in brain slices.	GLUD1 GLUD2	4.47e-06	2	74	2	37154294
Pubmed	Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.	GLUD1 GLUD2	4.47e-06	2	74	2	19015267
Pubmed	Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.	CYP11B1 CYP11B2	4.47e-06	2	74	2	1303253
Pubmed	Interaction between glutamate dehydrogenase (GDH) and L-leucine catabolic enzymes: intersecting metabolic pathways.	GLUD1 GLUD2	4.47e-06	2	74	2	21621574
Pubmed	Lack of evidence for direct ligand-gated ion channel activity of GluD receptors.	GLUD1 GLUD2	4.47e-06	2	74	2	39052831
Pubmed	Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.	CYP11B1 CYP11B2	4.47e-06	2	74	2	22622494
Pubmed	Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets.	CYP11B1 CYP11B2	4.47e-06	2	74	2	21519965
Pubmed	Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.	GLUD1 GLUD2	4.47e-06	2	74	2	22924626
Pubmed	Diagnosis of glucocorticoid-remediable aldosteronism in hypertensive children.	CYP11B1 CYP11B2	4.47e-06	2	74	2	21625068
Pubmed	Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice.	GLUD1 GLUD2	4.47e-06	2	74	2	24442550
Pubmed	Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production.	CYP11B1 CYP11B2	4.47e-06	2	74	2	15062555
Pubmed	Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.	GLUD1 GLUD2	4.47e-06	2	74	2	28911206
Pubmed	Genetic screening for glucocorticoid-remediable aldosteronism (GRA): experience of three clinical centres in Poland.	CYP11B1 CYP11B2	4.47e-06	2	74	2	16110193
Pubmed	Procollagen I-expressing renin cell precursors.	CYP11B1 CYP11B2	4.47e-06	2	74	2	23761669
Pubmed	Chimeric CYP11B2/CYP11B1 causing 11β-hydroxylase deficiency in Chinese patients with congenital adrenal hyperplasia.	CYP11B1 CYP11B2	4.47e-06	2	74	2	26066897
Pubmed	Activation of a muscle-specific enhancer by the Ski proto-oncogene.	MYOD1 SKI	4.47e-06	2	74	2	7659522
Pubmed	The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity.	GLUD1 GLUD2	4.47e-06	2	74	2	27137930
Pubmed	Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum.	GLUD1 GLUD2	4.47e-06	2	74	2	19448744
Pubmed	Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption.	CYP11B1 CYP11B2	4.47e-06	2	74	2	17075030
Pubmed	Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency.	CYP11B1 CYP11B2	4.47e-06	2	74	2	17075029
Pubmed	GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.	GLUD1 GLUD2	4.47e-06	2	74	2	26440896
Pubmed	Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).	CYP11B1 CYP11B2	4.47e-06	2	74	2	2592361
Pubmed	Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase.	GLUD1 GLUD2	4.47e-06	2	74	2	22875990
Pubmed	CYP11B2-CYP11B1 haplotypes associated with decreased 11 beta-hydroxylase activity.	CYP11B1 CYP11B2	4.47e-06	2	74	2	15507509
Pubmed	Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme.	GLUD1 GLUD2	4.47e-06	2	74	2	12742085
Pubmed	Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function.	GLUD1 GLUD2	4.47e-06	2	74	2	11032875
Pubmed	Polymorphism of CYP11B2 determines salt sensitivity in Japanese.	CYP11B1 CYP11B2	4.47e-06	2	74	2	17296872
Pubmed	Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice.	CYP11B1 CYP11B2	4.47e-06	2	74	2	23314847
Pubmed	Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects.	CYP11B1 CYP11B2	4.47e-06	2	74	2	17980006
Pubmed	Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene.	CYP11B1 CYP11B2	4.47e-06	2	74	2	16984984
Pubmed	Molecular basis of human glutamate dehydrogenase regulation under changing energy demands.	GLUD1 GLUD2	4.47e-06	2	74	2	15578726
Pubmed	Evidence for local aldosterone synthesis in the large intestine of the mouse.	CYP11B1 CYP11B2	4.47e-06	2	74	2	35288482
Pubmed	Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice.	CYP11B1 CYP11B2	4.47e-06	2	74	2	15731365
Pubmed	Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase.	CYP11B1 CYP11B2	4.47e-06	2	74	2	18039983
Pubmed	Important role of Ser443 in different thermal stability of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	4.47e-06	2	74	2	15044002
Pubmed	Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.	CYP11B1 CYP11B2	4.47e-06	2	74	2	1741400
Pubmed	Single amino acid substitution (G456A) in the vicinity of the GTP binding domain of human housekeeping glutamate dehydrogenase markedly attenuates GTP inhibition and abolishes the cooperative behavior of the enzyme.	GLUD1 GLUD2	4.47e-06	2	74	2	11950837
Pubmed	Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.	CYP11B1 CYP11B2	4.47e-06	2	74	2	19029289
Pubmed	Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice.	CYP11B1 CYP11B2	4.47e-06	2	74	2	32540969
Pubmed	Induction of excitatory and inhibitory presynaptic differentiation by GluD1.	GLUD1 GLUD2	4.47e-06	2	74	2	22138648
Pubmed	Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes.	GLUD1 GLUD2	4.47e-06	2	74	2	29943084
Pubmed	Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice.	CYP11B1 CYP11B2	4.47e-06	2	74	2	26047574
Pubmed	Aldosterone synthase knockout mouse as a model for sodium-induced endothelial sodium channel up-regulation in vascular endothelium.	CYP11B1 CYP11B2	4.47e-06	2	74	2	26324851
Pubmed	Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia.	GLUD1 GLUD2	4.47e-06	2	74	2	34220417
Pubmed	Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules.	CYP11B1 CYP11B2	4.47e-06	2	74	2	18651133
Pubmed	Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory.	GLUD1 GLUD2	4.47e-06	2	74	2	31898404
Pubmed	Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.	GLUD1 GLUD2	4.47e-06	2	74	2	15378063
Pubmed	Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains.	CYP11B1 CYP11B2	4.47e-06	2	74	2	7669222
Pubmed	Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.	GLUD1 GLUD2	4.47e-06	2	74	2	27422263
Pubmed	Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues.	GLUD1 GLUD2	4.47e-06	2	74	2	26241911
Pubmed	A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation pattern.	CYP11B1 CYP11B2	4.47e-06	2	74	2	22083159
Pubmed	Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.	CYP11B1 CYP11B2	4.47e-06	2	74	2	15522937
Pubmed	Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron.	CYP11B1 CYP11B2	4.47e-06	2	74	2	22933298
Pubmed	Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin.	GLUD1 GLUD2	1.34e-05	3	74	2	29784783
Pubmed	Isolation of a human brain cDNA for glutamate dehydrogenase.	GLUD1 GLUD2	1.34e-05	3	74	2	3585334
Pubmed	Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids.	CYP11B1 CYP11B2	1.34e-05	3	74	2	36861295
Pubmed	Aldosterone postnatally, but not at birth, is required for optimal induction of renal mineralocorticoid receptor expression and sodium reabsorption.	CYP11B1 CYP11B2	1.34e-05	3	74	2	21467193
Pubmed	Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior.	CYP11B1 CYP11B2	1.34e-05	3	74	2	36778748
Pubmed	Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain.	CYP11B1 CYP11B2	1.34e-05	3	74	2	8111631
Pubmed	The structure of apo human glutamate dehydrogenase details subunit communication and allostery.	GLUD1 GLUD2	1.34e-05	3	74	2	12054821
Cytoband	17q25.3	ZNF750 OXLD1 RNF213 BAHCC1	2.26e-05	101	74	4	17q25.3
Cytoband	Ensembl 112 genes in cytogenetic band chr17q25	CDR2L ZNF750 OXLD1 RNF213 BAHCC1	1.43e-04	307	74	5	chr17q25
Cytoband	3q23	ZBTB38 XRN1	2.32e-03	44	74	2	3q23
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF845 ZNF526 ZNF320 ZBTB38 ZBTB39 ZSCAN20 ZNF875 ZNF596 SP9 ZNF853 ZNF865 ZNF501 ZKSCAN5 ZNF786 ZNF697 ZNF646	7.15e-12	718	45	16	28
GeneFamily	Cytochrome P450 family 11	CYP11B1 CYP11B2	1.81e-05	3	45	2	1007
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	MTMR3 WDFY1	2.69e-03	31	45	2	81
Drug	phenyltriethoxysilane	GLUD1 GLUD2	9.59e-06	2	71	2	CID000013075
Drug	methylmercuric bromide	GLUD1 GLUD2	9.59e-06	2	71	2	CID000068175
Drug	5-methylisophthalate	GLUD1 GLUD2	9.59e-06	2	71	2	CID000068137
Drug	cyadox	CYP11B1 CYP11B2	9.59e-06	2	71	2	ctd:C020728
Drug	G-3SH	GLUD1 GLUD2	9.59e-06	2	71	2	CID000174237
Drug	x 1 s	GLUD1 GLUD2	9.59e-06	2	71	2	CID000409694
Drug	iodoacetyldiethylstilbestrol	GLUD1 GLUD2	9.59e-06	2	71	2	CID006455327
Drug	18-hydroxydeoxycorticosterone	CYP11B1 CYP11B2	9.59e-06	2	71	2	ctd:C042509
Drug	methoxyethylmercury	GLUD1 GLUD2	2.87e-05	3	71	2	CID000115155
Drug	4-methylumbelliferyl laurate	GLUD1 GLUD2	2.87e-05	3	71	2	CID000600674
Drug	methylmercuric iodide	GLUD1 GLUD2	2.87e-05	3	71	2	CID000067347
Drug	18-hydroxycortisol	CYP11B1 CYP11B2	2.87e-05	3	71	2	ctd:C033689
Drug	lenthionine	GLUD1 GLUD2	2.87e-05	3	71	2	CID000067521
Drug	mildiomycin	GLUD1 GLUD2	2.87e-05	3	71	2	CID000125665
Drug	methyl benzoquate	GLUD1 GLUD2	5.73e-05	4	71	2	CID000026383
Drug	8-BDB-TADP	GLUD1 GLUD2	5.73e-05	4	71	2	CID000130791
Drug	cadina-3,9-diene	GLUD1 GLUD2	5.73e-05	4	71	2	CID000010657
Drug	AC1L9CUQ	GLUD1 GLUD2	5.73e-05	4	71	2	CID000442451
Drug	pentenoic acid	GLUD1 GLUD2	5.73e-05	4	71	2	CID000012299
Drug	alpha-ketoglutaramate	GLUD1 GLUD2	5.73e-05	4	71	2	CID000000048
Drug	luxabendazole	GLUD1 GLUD2	5.73e-05	4	71	2	CID000072019
Drug	ureidoglycine	GLUD1 GLUD2	5.73e-05	4	71	2	CID000439649
Drug	N-butylmaleimide	GLUD1 GLUD2	5.73e-05	4	71	2	CID000239780
Drug	C05489	CYP11B1 CYP11B2	5.73e-05	4	71	2	CID000440708
Drug	Ivin	GLUD1 GLUD2	5.73e-05	4	71	2	CID000014083
Drug	alpha-methylglutamate	GLUD1 GLUD2	5.73e-05	4	71	2	CID000095440
Drug	2b E2	GLUD1 GLUD2	5.73e-05	4	71	2	CID005327076
Drug	1-pheg	GLUD1 GLUD2	9.53e-05	5	71	2	CID000152041
Drug	17alpha, 21-dihydroxypregnenolone	CYP11B1 CYP11B2	9.53e-05	5	71	2	CID000192735
Drug	5'-FSBAzA	GLUD1 GLUD2	9.53e-05	5	71	2	CID000130430
Drug	adenine N1-oxide	GLUD1 GLUD2	9.53e-05	5	71	2	CID000093557
Drug	bathocuproine	GLUD1 GLUD2	9.53e-05	5	71	2	CID000065149
Drug	choline sulfate	GLUD1 GLUD2	9.53e-05	5	71	2	CID000000485
Drug	l-413	GLUD1 GLUD2	9.53e-05	5	71	2	CID000012475
Drug	AC1NRA4I	GLUD1 GLUD2	9.53e-05	5	71	2	CID005287695
Drug	isosteviol lactone	GLUD1 GLUD2	9.53e-05	5	71	2	CID000401559
Drug	3-aminopicolinate	GLUD1 GLUD2	9.53e-05	5	71	2	CID000073836
Drug	alpha-monofluoromethylputrescine	GLUD1 GLUD2	1.43e-04	6	71	2	CID000134201
Drug	dadAB	GLUD1 GLUD2	1.43e-04	6	71	2	CID000022626
Drug	N-methylhydantoin	GLUD1 GLUD2	1.43e-04	6	71	2	CID000069217
Drug	diazonium-1-H-tetrazole	GLUD1 GLUD2	1.43e-04	6	71	2	CID000188312
Drug	Tetrahydronaphthalenes	CYP11B1 CYP11B2	1.43e-04	6	71	2	ctd:D013764
Drug	AC1L448Y	GLUD1 GLUD2	1.43e-04	6	71	2	CID000200389
Drug	2-BDB-TAMP	GLUD1 GLUD2	1.43e-04	6	71	2	CID000127220
Drug	Emid	GLUD1 GLUD2	1.43e-04	6	71	2	CID000074798
Drug	dimethylmalonate	GLUD1 GLUD2	1.43e-04	6	71	2	CID000007943
Drug	Methandrostenolone	CYP11B1 CYP11B2	1.43e-04	6	71	2	ctd:D008696
Drug	AC1L8SA5	GLUD1 GLUD2	1.43e-04	6	71	2	CID000407285
Drug	2-methyl-1,2,3,4-tetrahydroisoquinoline	GLUD1 GLUD2	1.43e-04	6	71	2	CID000015362
Drug	lanosol	GLUD1 GLUD2	1.43e-04	6	71	2	CID000078659
Drug	cholesteryl stearate	LIPA PRF1	1.43e-04	6	71	2	CID000118246
Drug	isodiazinon	GLUD1 GLUD2	1.43e-04	6	71	2	CID000133913
Drug	carbophenothion	GLUD1 GLUD2	1.99e-04	7	71	2	CID000013081
Drug	Mn-Ca	MYOD1 PRF1	1.99e-04	7	71	2	CID000115101
Drug	37474A	GLUD1 GLUD2	1.99e-04	7	71	2	CID004330138
Drug	AC1L1B5W	GLUD1 GLUD2	1.99e-04	7	71	2	CID000001296
Drug	2-oxoglutaconic acid	GLUD1 GLUD2	1.99e-04	7	71	2	CID006443759
Drug	d-serine methyl ester hydrochloride	GLUD1 GLUD2	1.99e-04	7	71	2	CID000090387
Drug	Cortodoxone	CYP11B1 CYP11B2	1.99e-04	7	71	2	ctd:D003350
Drug	tungsten	ARHGAP32 SEMA3C GLUD1 GLUD2	2.23e-04	95	71	4	CID000023964
Drug	6-chloroquinoxaline-2,3-diol	GLUD1 GLUD2	2.65e-04	8	71	2	CID000081143
Drug	2-heptanol	GLUD1 GLUD2	2.65e-04	8	71	2	CID000010976
Drug	2'(3')-O-(2,4,6-trinitrophenyl)-ADP	GLUD1 GLUD2	2.65e-04	8	71	2	CID000644359
Drug	2,2',3,3',4,6'-hexachlorobiphenyl	CYP11B1 CYP11B2	2.65e-04	8	71	2	ctd:C094859
Drug	Nessler's reagent	GLUD1 GLUD2	2.65e-04	8	71	2	CID000024542
Drug	iminoglutarate	GLUD1 GLUD2	2.65e-04	8	71	2	CID000152649
Drug	bidisomide	GLUD1 GLUD2	2.65e-04	8	71	2	CID000059798
Drug	Pheg	GLUD1 GLUD2	2.65e-04	8	71	2	CID003080746
Drug	AC1MQ2IK	GLUD1 GLUD2	2.65e-04	8	71	2	CID003394958
Drug	AC1N690Y	GLUD1 GLUD2	2.65e-04	8	71	2	CID004256264
Drug	trimethyllead chloride	GLUD1 GLUD2	2.65e-04	8	71	2	CID000223969
Drug	NHS-ASA	GLUD1 GLUD2	3.40e-04	9	71	2	CID003035647
Drug	GKT137831	CYP11B1 CYP11B2	3.40e-04	9	71	2	ctd:C576694
Drug	dimethyl L-glutamate	GLUD1 GLUD2	3.40e-04	9	71	2	CID000093032
Drug	AC1L1GWH	GLUD1 GLUD2	3.40e-04	9	71	2	CID000003872
Drug	AC1N4HBY	GLUD1 GLUD2	3.40e-04	9	71	2	CID004128835
Drug	DCQX	GLUD1 GLUD2	3.40e-04	9	71	2	CID000001845
Drug	2,2',3,4',5',6-hexachlorobiphenyl	CYP11B1 CYP11B2	3.40e-04	9	71	2	ctd:C120129
Drug	adipamide	GLUD1 GLUD2	3.40e-04	9	71	2	CID000012364
Drug	temelastine	GLUD1 GLUD2	3.40e-04	9	71	2	CID000055482
Drug	Asparagusate	GLUD1 GLUD2	3.40e-04	9	71	2	CID000016682
Drug	bis-NAD	GLUD1 GLUD2	4.25e-04	10	71	2	CID003081557
Drug	NmiQ	GLUD1 GLUD2	4.25e-04	10	71	2	CID000019850
Drug	S884	GLUD1 GLUD2	4.25e-04	10	71	2	CID004685067
Drug	Indans	CYP11B1 CYP11B2	4.25e-04	10	71	2	ctd:D007189
Drug	diglycerol	GLUD1 GLUD2	4.25e-04	10	71	2	CID000042953
Drug	perflubron	CYP11B1 CYP11B2	4.25e-04	10	71	2	ctd:C003072
Drug	enniatins	CYP11B1 CYP11B2 TFB2M	4.54e-04	48	71	3	ctd:C100264
Drug	silver nitrate	ARHGAP32 GLUD1 GLUD2	4.83e-04	49	71	3	CID000024470
Drug	sulfoacetic acid	GLUD1 GLUD2	5.18e-04	11	71	2	CID000031257
Drug	ADP-ribosylcysteine	GLUD1 GLUD2	5.18e-04	11	71	2	CID003035804
Drug	5-ethylphenazin-5-ium	GLUD1 GLUD2	5.18e-04	11	71	2	CID000082689
Drug	2,3,3',4,4',5-hexachlorobiphenyl	CYP11B1 CYP11B2	5.18e-04	11	71	2	ctd:C087667
Drug	kievitone	GLUD1 GLUD2	5.18e-04	11	71	2	CID000119269
Drug	AC1O3MP2	GLUD1 GLUD2	5.18e-04	11	71	2	CID006332324
Drug	Sonazoid	PRF1 LAMB2	6.20e-04	12	71	2	CID000009638
Drug	Methylthioacetylaminoethanol	GLUD1 GLUD2	6.20e-04	12	71	2	CID000155653
Drug	nitroparacetamol	GLUD1 GLUD2	6.20e-04	12	71	2	CID006918532
Drug	5'-deoxypyridoxal	GLUD1 GLUD2	6.20e-04	12	71	2	CID000164889
Drug	AC1O3Q5W	GLUD1 GLUD2	6.20e-04	12	71	2	CID006334250
Disease	adrenal cortical adenoma (is_marker_for)	CYP11B1 CYP11B2	5.39e-06	2	69	2	DOID:0050891 (is_marker_for)
Disease	Glucocorticoid-remediable aldosteronism	CYP11B1 CYP11B2	5.39e-06	2	69	2	C1260386
Disease	congenital adrenal hyperplasia (implicated_via_orthology)	CYP11B1 CYP11B2	1.61e-05	3	69	2	DOID:0050811 (implicated_via_orthology)
Disease	fascioliasis (biomarker_via_orthology)	GLUD1 GLUD2	1.61e-05	3	69	2	DOID:885 (biomarker_via_orthology)
Disease	primary hyperaldosteronism (is_implicated_in)	CYP11B1 CYP11B2	5.36e-05	5	69	2	DOID:446 (is_implicated_in)
Disease	childhood absence epilepsy (biomarker_via_orthology)	GLUD1 GLUD2	8.03e-05	6	69	2	DOID:1825 (biomarker_via_orthology)
Disease	Conn Syndrome	CYP11B1 CYP11B2	8.03e-05	6	69	2	C1384514
Disease	Hyperaldosteronism	CYP11B1 CYP11B2	8.03e-05	6	69	2	C0020428
Disease	protocadherin alpha-7 measurement	CYP11B1 CYP11B2	1.12e-04	7	69	2	EFO_0801973
Disease	interleukin 27 receptor subunit alpha measurement	DCAF15 CYP11B1	1.50e-04	8	69	2	EFO_0008183
Disease	protein FAM163B measurement	CYP11B1 CYP11B2	1.92e-04	9	69	2	EFO_0802936
Disease	androstenedione measurement	CYP11B1 CYP11B2	2.40e-04	10	69	2	EFO_0007972
Disease	3-hydroxyanthranilate 3,4-dioxygenase measurement	CYP11B1 CYP11B2	2.92e-04	11	69	2	EFO_0021862
Disease	cell growth regulator with EF hand domain protein 1 measurement	CYP11B1 CYP11B2	2.92e-04	11	69	2	EFO_0801461
Disease	hepatic encephalopathy (biomarker_via_orthology)	GLUD1 GLUD2	5.55e-04	15	69	2	DOID:13413 (biomarker_via_orthology)
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	AARS2 MTMR3	1.44e-03	24	69	2	DOID:10595 (implicated_via_orthology)
Disease	apolipoprotein L1 measurement	CYP11B1 CYP11B2	1.56e-03	25	69	2	EFO_0021854
Disease	hypertension (biomarker_via_orthology)	MYOD1 CYP11B1 CYP11B2 SLC6A19	1.99e-03	227	69	4	DOID:10763 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
HSRLRGRQHGPNVCA	TGFBI	36	Q15582
ALRSKGSGPHAHAQR	BAHCC1	2406	Q9P281
QGLAHCKLRLPGSRH	AGBL3	701	Q8NEM8
LSKCRQHGAGVRHAG	CDR2L	371	Q86X02
TRNSACKPRGQLSGH	LINC01590	51	Q5TEZ4
GRKRHTPLHNACANG	ASB16	281	Q96NS5
CGVGRGDRPLRHHNS	CARNS1	251	A5YM72
ARCRNHGVVSALKGH	DMRTA2	71	Q96SC8
TNGHGSHRLCILRQP	ALPK1	866	Q96QP1
LNTRTQKARHCGHCP	KLRC1	106	P26715
KHHKPGQQHLRGRPC	PGBD4	496	Q96DM1
QLRGAGFGPQHNRHC	OCIAD2	116	Q56VL3
NLSHKGIGEPCRRHE	LRCOL1	31	A6NCL2
LVCRLAHGHFPRKGQ	MIR7-3HG	6	Q8N6C7
AQGRAPSHRRGNHSK	LARGE1	86	O95461
RQGPGAHLCHQKSSS	MCTP1	186	Q6DN14
KGCGNPGSSRHRDSH	GARIN4	476	Q8IYT1
APRHADGKLGRTCDH	LINC02693	11	A8MQB3
FNQHMKRNHPGCGRS	HERC1	2991	Q15751
KRNHPGCGRSANRQG	HERC1	2996	Q15751
PKSGSHEVRCNLNHG	PRF1	501	P14222
VRAPSGHHQAGRCLL	MYOD1	81	P15172
CHSHSPFRNERGKGK	EXPH5	961	Q8NEV8
HCKPGFHGQAARQSC	LAMB2	1021	P55268
KGAQGISCGRHLANH	EDC3	346	Q96F86
GRNASGHHSKPCSRV	ARHGAP32	1541	A7KAX9
CQRLPGGGSFLQRHH	OXLD1	31	Q5BKU9
PNCHNCGTHIGLRSK	GIG44	36	P09565
AGCHCPANLVLHKGR	BMPER	661	Q8N8U9
QGSGKRLSHRLPHIC	C18orf15	56	Q96N68
RAQHSQHRTPCKGGI	GLUD1	136	P00367
PPGCLRSHQHASQRA	GAB4	211	Q2WGN9
SQKAEPLCLGHFHNR	CCDC191	541	Q8NCU4
QHRGHKCGVFLLNGP	CYP11B1	121	P15538
QHRGHKCGVFLLNGP	CYP11B2	121	P19099
PKASSLRGHKGHQCL	CCDC159	251	P0C7I6
RAHPGDPNAQCLRHG	DCAF15	201	Q66K64
RAQHSQHRTPCKGGI	GLUD2	136	P49448
QGHHRSCLVNSGKDR	MTMR3	861	Q13615
RTHNGGCQHRCVNTP	MEGF6	166	O75095
GLHRHFSQEPRKNCS	PLEKHM1	476	Q9Y4G2
IRNHCQKPGDHQGLV	SLC6A19	606	Q695T7
RHGNPLTQCRGFNLK	SEMA3C	556	Q99985
ATRKHLPARNHCGLS	TFB2M	31	Q9H5Q4
RTGCLRKNGLHSSGH	STARD9	886	Q9P2P6
STHSQAGCARHLGKP	NPAP1	241	Q9NZP6
GSSNKSLGCVHPRQR	SKI	361	P12755
PAGASLRRKGLHSCH	SP9	321	P0CG40
RVANSQKCVRAGGHH	AARS2	101	Q5JTZ9
ANGAHPGRHQRSFAC	C10orf90	181	Q96M02
GSTNRHDQRHAGNKP	ZNF845	121	Q96IR2
LGLGTHRVKCRVHPN	RNF213	3131	Q63HN8
GTHRCLGQKPALHRA	ZNF750	121	Q32MQ0
APNHRAAGLENGHCL	PHETA2	161	Q6ICB4
KHLAAHQGGRPFRCS	ZNF865	1006	P0CJ78
CGKAFNSPSHLIRHQ	ZNF320	446	A2RRD8
RQHERSHNGEKPHGC	ZNF596	351	Q8TC21
GKRGHAFAQCPKAVH	ZCCHC3	376	Q9NUD5
KHQRIHLGGNPDQCS	ZSCAN20	811	P17040
ANRPSLDAHLGGRKH	TUT1	26	Q9H6E5
NHLRNHPRCKGSEPQ	ZNF646	1096	O15015
SRRNPHGDHKANVGL	XRN1	941	Q8IZH2
NPRSHEKLHIVNCGG	WDR6	641	Q9NNW5
RAPAVGCRQRSGHLH	nan	101	Q3C1V9
HVSQHKCNSGLDARP	ZBTB39	556	O15060
HRRIHTGNKPHKCAG	ZNF697	511	Q5TEC3
QHAHGGERPFSCRKC	ZNF786	416	Q8N393
RPHRCGECGKGFSQH	ZNF853	511	P0CG23
AHTANPLHRCRCGKT	ZNF526	381	Q8TF50
KHQRAHAGGKPHVCR	ZNF875	596	P10072
KAVGAGNQGRPHRHL	ZBTB38	991	Q8NAP3
GCHGHPTVEAKLRNQ	TRPM8	266	Q7Z2W7
CKFPGNTGRQHRQRH	RPTN	111	Q6XPR3
TLGLRQHHCRKCGQA	WDFY1	306	Q8IWB7
RHQRSHSGDKPFKCN	ZNF501	151	Q96CX3
PKQSTHGERGHRCSD	ZKSCAN5	336	Q9Y2L8
LCLNRIPHGRKNHSD	LIPA	61	P38571