Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionamyloid-beta binding

EPHB2 GRIA4 GRIN2B PRNP

2.34e-05102334GO:0001540
GeneOntologyMolecularFunctioncalmodulin-dependent protein phosphatase activity

PPP3CA PPP3CB

2.64e-055332GO:0033192
GeneOntologyMolecularFunctioncalcium-dependent protein serine/threonine phosphatase activity

PPP3CA PPP3CB

7.37e-058332GO:0004723
GeneOntologyMolecularFunctionamide binding

EPHB2 GRIA4 GRIN2B PPP3CA PRNP

1.23e-04299335GO:0033218
GeneOntologyMolecularFunctionglutamate-gated receptor activity

GRIA4 GRIN2B

3.55e-0417332GO:0004970
GeneOntologyMolecularFunctionlamin binding

AKAP8L PRNP

4.45e-0419332GO:0005521
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

GRIA4 GRIN2B

7.15e-0424332GO:0099507
GeneOntologyMolecularFunctionglutamate receptor activity

GRIA4 GRIN2B

9.06e-0427332GO:0008066
GeneOntologyMolecularFunctionpeptide binding

EPHB2 GRIA4 GRIN2B PRNP

1.79e-03318334GO:0042277
GeneOntologyBiologicalProcessgrowth

OLFM1 CLASP2 ITCH EPPK1 PPP3CA ACVR1B PPP3CB NCAPG2 USP9X RBM10 RAB33B

1.93e-0612353311GO:0040007
GeneOntologyBiologicalProcessregulation of dendritic spine maintenance

NEDD9 GRIN2B PRNP

3.00e-0618333GO:1902950
GeneOntologyBiologicalProcessregulation of calcium ion import across plasma membrane

PPP3CA PPP3CB PRNP

3.55e-0619333GO:1905664
GeneOntologyBiologicalProcesscell growth

OLFM1 CLASP2 ITCH ACVR1B PPP3CB USP9X RBM10 RAB33B

4.83e-06625338GO:0016049
GeneOntologyBiologicalProcessregulation of postsynapse organization

EPHB2 NEDD9 GRIN2B USP9X PRNP

1.06e-05185335GO:0099175
GeneOntologyBiologicalProcessregulation of cellular localization

EPHB2 PTPN5 NEDD9 LRP2 CLASP2 PPP3CA PPP3CB AKAP8L RBM10 PRNP

1.26e-0512123310GO:0060341
GeneOntologyBiologicalProcessdendritic spine maintenance

NEDD9 GRIN2B PRNP

1.47e-0530333GO:0097062
GeneOntologyBiologicalProcesspositive regulation of synaptic transmission

EPHB2 PTPN5 GRIA4 GRIN2B PRNP

3.23e-05233335GO:0050806
GeneOntologyBiologicalProcessdendritic spine organization

EPHB2 NEDD9 GRIN2B PRNP

3.31e-05115334GO:0097061
GeneOntologyBiologicalProcesspositive regulation of protein localization

EPHB2 PTPN5 NEDD9 LRP2 CLASP2 PPP3CB PRNP

3.42e-05591337GO:1903829
GeneOntologyBiologicalProcessnegative regulation of dendritic spine maintenance

GRIN2B PRNP

3.71e-056332GO:1902951
GeneOntologyBiologicalProcessregulation of calcineurin-NFAT signaling cascade

PPP3CA PPP3CB PRNP

4.73e-0544333GO:0070884
GeneOntologyBiologicalProcessneuron projection organization

EPHB2 NEDD9 GRIN2B PRNP

4.88e-05127334GO:0106027
GeneOntologyBiologicalProcessregulation of calcineurin-mediated signaling

PPP3CA PPP3CB PRNP

5.06e-0545333GO:0106056
GeneOntologyBiologicalProcesscalcium ion import across plasma membrane

PPP3CA PPP3CB PRNP

6.14e-0548333GO:0098703
GeneOntologyBiologicalProcesscalcium ion import into cytosol

PPP3CA PPP3CB PRNP

6.14e-0548333GO:1902656
GeneOntologyBiologicalProcessaxon extension

OLFM1 CLASP2 PPP3CB USP9X

6.20e-05135334GO:0048675
GeneOntologyBiologicalProcessmodulation of chemical synaptic transmission

EPHB2 PTPN5 GRIA4 GRIN2B PPP3CA PPP3CB PRNP

7.08e-05663337GO:0050804
GeneOntologyBiologicalProcessregulation of trans-synaptic signaling

EPHB2 PTPN5 GRIA4 GRIN2B PPP3CA PPP3CB PRNP

7.15e-05664337GO:0099177
GeneOntologyBiologicalProcessdevelopmental growth

OLFM1 CLASP2 EPPK1 PPP3CA PPP3CB NCAPG2 USP9X RBM10

7.28e-05911338GO:0048589
GeneOntologyBiologicalProcessregulation of vesicle-mediated transport

PTPN5 LRP2 CLASP2 PPP3CA PPP3CB USH1G RAB33B

7.35e-05667337GO:0060627
GeneOntologyBiologicalProcesslong-term synaptic potentiation

EPHB2 PTPN5 GRIN2B PRNP

7.97e-05144334GO:0060291
GeneOntologyBiologicalProcesscalcineurin-NFAT signaling cascade

PPP3CA PPP3CB PRNP

8.75e-0554333GO:0033173
GeneOntologyBiologicalProcessnegative regulation of calcium ion import across plasma membrane

PPP3CA PPP3CB

8.87e-059332GO:1905949
GeneOntologyBiologicalProcessregulation of synaptic plasticity

EPHB2 PTPN5 GRIN2B PPP3CB PRNP

9.58e-05293335GO:0048167
GeneOntologyBiologicalProcesscalcineurin-mediated signaling

PPP3CA PPP3CB PRNP

1.08e-0458333GO:0097720
GeneOntologyBiologicalProcessdevelopmental cell growth

OLFM1 CLASP2 PPP3CB USP9X RBM10

1.09e-04301335GO:0048588
GeneOntologyBiologicalProcessglutamate receptor signaling pathway

GRIA4 GRIN2B PRNP

1.14e-0459333GO:0007215
GeneOntologyBiologicalProcessregulation of calcium ion import

PPP3CA PPP3CB PRNP

1.26e-0461333GO:0090279
GeneOntologyBiologicalProcesspostsynapse organization

EPHB2 NEDD9 GRIN2B USP9X PRNP

1.31e-04313335GO:0099173
GeneOntologyBiologicalProcessneuron projection development

EPHB2 PTPN5 LRP2 OLFM1 CLASP2 PPP3CA PPP3CB USH1G USP9X

1.36e-041285339GO:0031175
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

EPHB2 LRP2 OLFM1 CLASP2 PPP3CA PPP3CB USP9X

1.50e-04748337GO:0048667
GeneOntologyBiologicalProcessregulation of cell growth

OLFM1 CLASP2 ITCH ACVR1B RBM10 RAB33B

1.53e-04519336GO:0001558
GeneOntologyBiologicalProcessregulation of long-term synaptic potentiation

EPHB2 PTPN5 PRNP

1.67e-0467333GO:1900271
GeneOntologyBiologicalProcesspositive regulation of calcium-mediated signaling

PPP3CA PPP3CB PRNP

1.90e-0470333GO:0050850
GeneOntologyBiologicalProcessregulation of growth

OLFM1 CLASP2 ITCH EPPK1 ACVR1B RBM10 RAB33B

1.90e-04777337GO:0040008
GeneOntologyBiologicalProcessregulation of ribonucleoprotein complex localization

AKAP8L RBM10

1.91e-0413332GO:2000197
GeneOntologyBiologicalProcesspositive regulation of calcium ion import across plasma membrane

PPP3CA PPP3CB

1.91e-0413332GO:1905665
GeneOntologyBiologicalProcessribonucleoprotein complex localization

AKAP8L RBM10

2.23e-0414332GO:0071166
GeneOntologyBiologicalProcessneuron projection morphogenesis

EPHB2 LRP2 OLFM1 CLASP2 PPP3CA PPP3CB USP9X

2.31e-04802337GO:0048812
GeneOntologyBiologicalProcessaxonogenesis

EPHB2 LRP2 OLFM1 CLASP2 PPP3CB USP9X

2.45e-04566336GO:0007409
GeneOntologyBiologicalProcessregulation of protein localization

EPHB2 PTPN5 NEDD9 LRP2 CLASP2 PPP3CA PPP3CB PRNP

2.47e-041087338GO:0032880
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

EPHB2 LRP2 OLFM1 CLASP2 PPP3CA PPP3CB USP9X

2.62e-04819337GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

EPHB2 LRP2 OLFM1 CLASP2 PPP3CA PPP3CB USP9X

2.76e-04826337GO:0048858
GeneOntologyBiologicalProcesslearning or memory

EPHB2 NEDD9 GRIN2B PPP3CB PRNP

2.95e-04373335GO:0007611
GeneOntologyBiologicalProcessembryo development

EPHB2 LRP2 CLASP2 GRIN2B KEAP1 ACVR1B NCAPG2 USH1G USP9X

3.15e-041437339GO:0009790
GeneOntologyBiologicalProcessneuron projection extension

OLFM1 CLASP2 PPP3CB USP9X

3.21e-04207334GO:1990138
GeneOntologyBiologicalProcessregulation of synapse organization

EPHB2 NEDD9 GRIN2B USP9X PRNP

3.49e-04387335GO:0050807
GeneOntologyBiologicalProcessregulation of endocytosis

PTPN5 LRP2 PPP3CA PPP3CB USH1G

3.57e-04389335GO:0030100
GeneOntologyBiologicalProcessneuron development

EPHB2 PTPN5 LRP2 OLFM1 CLASP2 PPP3CA PPP3CB USH1G USP9X

3.60e-041463339GO:0048666
GeneOntologyBiologicalProcessregulation of synapse structure or activity

EPHB2 NEDD9 GRIN2B USP9X PRNP

3.83e-04395335GO:0050803
GeneOntologyBiologicalProcesscalcium ion transmembrane import into cytosol

GRIN2B PPP3CA PPP3CB PRNP

3.84e-04217334GO:0097553
GeneOntologyBiologicalProcesslymphocyte proliferation

EPHB2 ITCH PPP3CA PPP3CB PRNP

3.97e-04398335GO:0046651
GeneOntologyBiologicalProcessmononuclear cell proliferation

EPHB2 ITCH PPP3CA PPP3CB PRNP

4.34e-04406335GO:0032943
GeneOntologyBiologicalProcessimport across plasma membrane

LRP2 PPP3CA PPP3CB PRNP

4.78e-04230334GO:0098739
GeneOntologyBiologicalProcessaxon development

EPHB2 LRP2 OLFM1 CLASP2 PPP3CB USP9X

4.80e-04642336GO:0061564
GeneOntologyBiologicalProcessregulation of monoatomic ion transmembrane transport

EPHB2 GRIN2B PPP3CA PPP3CB PRNP

4.91e-04417335GO:0034765
GeneOntologyBiologicalProcessnegative regulation of cell projection organization

EPHB2 GRIN2B PPP3CA PRNP

5.02e-04233334GO:0031345
GeneOntologyBiologicalProcesspositive regulation of calcineurin-mediated signaling

PPP3CA PPP3CB

5.11e-0421332GO:0106058
GeneOntologyBiologicalProcesspositive regulation of calcineurin-NFAT signaling cascade

PPP3CA PPP3CB

5.11e-0421332GO:0070886
GeneOntologyBiologicalProcessnegative regulation of calcium ion import

PPP3CA PPP3CB

5.11e-0421332GO:0090281
GeneOntologyBiologicalProcesscalcium ion import

PPP3CA PPP3CB PRNP

5.12e-0498333GO:0070509
GeneOntologyBiologicalProcesscognition

EPHB2 NEDD9 GRIN2B PPP3CB PRNP

5.24e-04423335GO:0050890
GeneOntologyBiologicalProcesscellular component maintenance

NEDD9 GRIN2B PRNP

5.59e-04101333GO:0043954
GeneOntologyBiologicalProcessanterograde trans-synaptic signaling

EPHB2 PTPN5 GRIA4 GRIN2B PPP3CA PPP3CB PRNP

5.69e-04931337GO:0098916
GeneOntologyBiologicalProcesschemical synaptic transmission

EPHB2 PTPN5 GRIA4 GRIN2B PPP3CA PPP3CB PRNP

5.69e-04931337GO:0007268
GeneOntologyBiologicalProcesstrans-synaptic signaling

EPHB2 PTPN5 GRIA4 GRIN2B PPP3CA PPP3CB PRNP

5.99e-04939337GO:0099537
GeneOntologyBiologicalProcesspositive regulation of immune system process

EPHB2 NEDD9 ITCH PPP3CA USP9X PRNP EPG5 TXK

6.06e-041242338GO:0002684
GeneOntologyBiologicalProcessleukocyte proliferation

EPHB2 ITCH PPP3CA PPP3CB PRNP

6.59e-04445335GO:0070661
GeneOntologyBiologicalProcesssynapse organization

EPHB2 NEDD9 CLASP2 GRIN2B USP9X PRNP

6.76e-04685336GO:0050808
GeneOntologyBiologicalProcesslymphocyte activation

EPHB2 NEDD9 ITCH PPP3CA PPP3CB PRNP TXK

7.53e-04976337GO:0046649
GeneOntologyBiologicalProcesssynaptic signaling

EPHB2 PTPN5 GRIA4 GRIN2B PPP3CA PPP3CB PRNP

7.53e-04976337GO:0099536
GeneOntologyBiologicalProcesscalcium-mediated signaling

GRIN2B PPP3CA PPP3CB PRNP

8.24e-04266334GO:0019722
GeneOntologyBiologicalProcessionotropic glutamate receptor signaling pathway

GRIA4 GRIN2B

8.50e-0427332GO:0035235
GeneOntologyBiologicalProcessregulation of calcium-mediated signaling

PPP3CA PPP3CB PRNP

9.45e-04121333GO:0050848
GeneOntologyBiologicalProcessnegative regulation of monoatomic ion transmembrane transport

EPHB2 PPP3CA PPP3CB

1.01e-03124333GO:0034766
GeneOntologyBiologicalProcessmulticellular organismal response to stress

EPHB2 GRIN2B PPP3CA

1.06e-03126333GO:0033555
GeneOntologyBiologicalProcessT cell proliferation

ITCH PPP3CA PPP3CB PRNP

1.11e-03288334GO:0042098
GeneOntologyBiologicalProcesspositive regulation of cellular component organization

EPHB2 PTPN5 NEDD9 LRP2 CLASP2 PPP3CA PPP3CB NCAPG2

1.13e-031366338GO:0051130
GeneOntologyBiologicalProcesspositive regulation of protein localization to membrane

EPHB2 CLASP2 PRNP

1.16e-03130333GO:1905477
GeneOntologyBiologicalProcessregulation of presynaptic membrane potential

GRIA4 GRIN2B

1.19e-0332332GO:0099505
GeneOntologyBiologicalProcesspositive regulation of myeloid cell differentiation

NEDD9 PPP3CA ACVR1B

1.27e-03134333GO:0045639
GeneOntologyBiologicalProcessdevelopmental growth involved in morphogenesis

OLFM1 CLASP2 PPP3CB USP9X

1.27e-03299334GO:0060560
GeneOntologyBiologicalProcessregulation of lymphocyte proliferation

EPHB2 ITCH PPP3CA PRNP

1.30e-03301334GO:0050670
GeneOntologyBiologicalProcessimport into cell

PTPN5 LRP2 ITCH PPP3CA PPP3CB USH1G PRNP

1.32e-031074337GO:0098657
GeneOntologyBiologicalProcesspositive regulation of long-term synaptic potentiation

EPHB2 PTPN5

1.35e-0334332GO:1900273
GeneOntologyBiologicalProcesspositive regulation of calcium ion import

PPP3CA PPP3CB

1.35e-0334332GO:0090280
GeneOntologyBiologicalProcesspositive regulation of transport

EPHB2 PTPN5 LRP2 CLASP2 GRIN2B PPP3CA PPP3CB

1.37e-031081337GO:0051050
GeneOntologyBiologicalProcessregulation of mononuclear cell proliferation

EPHB2 ITCH PPP3CA PRNP

1.38e-03306334GO:0032944
GeneOntologyBiologicalProcessregulation of immune response

EPHB2 ITCH PPP3CB USP9X PRNP EPG5 TXK

1.40e-031085337GO:0050776
GeneOntologyBiologicalProcesspositive regulation of protein tyrosine kinase activity

NEDD9 PRNP

1.43e-0335332GO:0061098
GeneOntologyBiologicalProcessinorganic ion import across plasma membrane

PPP3CA PPP3CB PRNP

1.50e-03142333GO:0099587
GeneOntologyBiologicalProcessregulation of nucleocytoplasmic transport

PTPN5 AKAP8L RBM10

1.50e-03142333GO:0046822
GeneOntologyBiologicalProcessinorganic cation import across plasma membrane

PPP3CA PPP3CB PRNP

1.50e-03142333GO:0098659
GeneOntologyCellularComponentdistal axon

LRP2 OLFM1 GRIA4 CLASP2 GRIN2B USP9X PRNP

5.33e-06435347GO:0150034
GeneOntologyCellularComponentaxon

EPHB2 PTPN5 LRP2 OLFM1 GRIA4 CLASP2 GRIN2B USP9X PRNP

8.94e-06891349GO:0030424
GeneOntologyCellularComponentcalcineurin complex

PPP3CA PPP3CB

3.84e-056342GO:0005955
GeneOntologyCellularComponentionotropic glutamate receptor complex

OLFM1 GRIA4 GRIN2B

5.32e-0545343GO:0008328
GeneOntologyCellularComponentaxonal growth cone

LRP2 OLFM1 CLASP2

5.32e-0545343GO:0044295
GeneOntologyCellularComponentdendrite

EPHB2 PTPN5 BRINP2 LRP2 GRIA4 GRIN2B PPP3CA PRNP

5.47e-05858348GO:0030425
GeneOntologyCellularComponentdendritic tree

EPHB2 PTPN5 BRINP2 LRP2 GRIA4 GRIN2B PPP3CA PRNP

5.56e-05860348GO:0097447
GeneOntologyCellularComponentneurotransmitter receptor complex

OLFM1 GRIA4 GRIN2B

7.31e-0550343GO:0098878
GeneOntologyCellularComponentsomatodendritic compartment

EPHB2 PTPN5 BRINP2 LRP2 OLFM1 GRIA4 GRIN2B PPP3CA PRNP

1.11e-041228349GO:0036477
GeneOntologyCellularComponentglutamatergic synapse

EPHB2 OLFM1 GRIA4 CLASP2 GRIN2B PPP3CA PPP3CB

2.90e-04817347GO:0098978
GeneOntologyCellularComponentterminal bouton

GRIA4 GRIN2B PRNP

5.07e-0496343GO:0043195
GeneOntologyCellularComponentdendritic spine

EPHB2 GRIA4 GRIN2B PPP3CA

6.18e-04242344GO:0043197
GeneOntologyCellularComponentgrowth cone

LRP2 OLFM1 CLASP2 USP9X

6.48e-04245344GO:0030426
GeneOntologyCellularComponentneuron spine

EPHB2 GRIA4 GRIN2B PPP3CA

6.68e-04247344GO:0044309
GeneOntologyCellularComponentsite of polarized growth

LRP2 OLFM1 CLASP2 USP9X

7.30e-04253344GO:0030427
GeneOntologyCellularComponentpostsynapse

EPHB2 OLFM1 GRIA4 GRIN2B PPP3CA USP9X PRNP

1.08e-031018347GO:0098794
GeneOntologyCellularComponentAMPA glutamate receptor complex

OLFM1 GRIA4

1.09e-0330342GO:0032281
GeneOntologyCellularComponentneuron to neuron synapse

EPHB2 OLFM1 GRIA4 GRIN2B PRNP

1.47e-03523345GO:0098984
GeneOntologyCellularComponentZ disc

GRIN2B PPP3CA PPP3CB

1.88e-03151343GO:0030018
GeneOntologyCellularComponentneuronal cell body

EPHB2 PTPN5 BRINP2 OLFM1 GRIA4 GRIN2B

2.06e-03835346GO:0043025
GeneOntologyCellularComponentpostsynaptic density membrane

OLFM1 GRIA4 GRIN2B

2.10e-03157343GO:0098839
GeneOntologyCellularComponentreceptor complex

LRP2 OLFM1 GRIA4 GRIN2B ACVR1B

2.33e-03581345GO:0043235
GeneOntologyCellularComponentsynaptic membrane

EPHB2 PTPN5 OLFM1 GRIA4 GRIN2B

2.36e-03583345GO:0097060
GeneOntologyCellularComponentplasma membrane signaling receptor complex

OLFM1 GRIA4 GRIN2B ACVR1B

2.41e-03350344GO:0098802
GeneOntologyCellularComponentI band

GRIN2B PPP3CA PPP3CB

2.46e-03166343GO:0031674
GeneOntologyCellularComponentpresynapse

EPHB2 PTPN5 GRIA4 GRIN2B PRNP RAB33B

2.77e-03886346GO:0098793
GeneOntologyCellularComponentcell body

EPHB2 PTPN5 BRINP2 OLFM1 GRIA4 GRIN2B

3.51e-03929346GO:0044297
GeneOntologyCellularComponentphosphatase complex

PPP3CA PPP3CB

3.61e-0355342GO:1903293
GeneOntologyCellularComponentprotein serine/threonine phosphatase complex

PPP3CA PPP3CB

3.61e-0355342GO:0008287
GeneOntologyCellularComponentpostsynaptic membrane

EPHB2 OLFM1 GRIA4 GRIN2B

4.07e-03405344GO:0045211
GeneOntologyCellularComponentpostsynaptic specialization membrane

OLFM1 GRIA4 GRIN2B

4.21e-03201343GO:0099634
GeneOntologyCellularComponentaxon terminus

GRIA4 GRIN2B PRNP

4.75e-03210343GO:0043679
GeneOntologyCellularComponentnuclear speck

NCAPG2 USH1G AKAP8L RBM10

5.07e-03431344GO:0016607
GeneOntologyCellularComponenthippocampal mossy fiber to CA3 synapse

EPHB2 GRIN2B

5.31e-0367342GO:0098686
GeneOntologyCellularComponentcell-substrate junction

NEDD9 CLASP2 EPPK1 KEAP1

5.58e-03443344GO:0030055
GeneOntologyCellularComponentpostsynaptic density

OLFM1 GRIA4 GRIN2B PRNP

5.94e-03451344GO:0014069
GeneOntologyCellularComponentextrinsic component of membrane

OLFM1 PPP3CA PRNP

6.12e-03230343GO:0019898
GeneOntologyCellularComponentneuron projection terminus

GRIA4 GRIN2B PRNP

6.34e-03233343GO:0044306
GeneOntologyCellularComponentpresynaptic active zone membrane

GRIA4 GRIN2B

7.14e-0378342GO:0048787
GeneOntologyCellularComponentasymmetric synapse

OLFM1 GRIA4 GRIN2B PRNP

7.22e-03477344GO:0032279
GeneOntologyCellularComponentsarcomere

GRIN2B PPP3CA PPP3CB

7.61e-03249343GO:0030017
GeneOntologyCellularComponentpostsynaptic specialization

OLFM1 GRIA4 GRIN2B PRNP

8.68e-03503344GO:0099572
GeneOntologyCellularComponentinclusion body

KEAP1 PRNP

9.40e-0390342GO:0016234
GeneOntologyCellularComponentmyofibril

GRIN2B PPP3CA PPP3CB

9.78e-03273343GO:0030016
GeneOntologyCellularComponentpresynaptic membrane

EPHB2 GRIA4 GRIN2B

1.02e-02277343GO:0042734
GeneOntologyCellularComponentsupramolecular fiber

CLASP2 GRIN2B EPPK1 KEAP1 PPP3CA PPP3CB

1.10e-021179346GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

CLASP2 GRIN2B EPPK1 KEAP1 PPP3CA PPP3CB

1.13e-021187346GO:0099081
GeneOntologyCellularComponentcontractile muscle fiber

GRIN2B PPP3CA PPP3CB

1.15e-02290343GO:0043292
DomainSer/Thr-sp_prot-phosphatase

PPP3CA PPP3CB

2.33e-0413332IPR006186
DomainSER_THR_PHOSPHATASE

PPP3CA PPP3CB

2.33e-0413332PS00125
DomainPP2Ac

PPP3CA PPP3CB

2.33e-0413332SM00156
DomainIontro_rcpt

GRIA4 GRIN2B

4.55e-0418332IPR001320
DomainLig_chan

GRIA4 GRIN2B

4.55e-0418332PF00060
DomainLig_chan-Glu_bd

GRIA4 GRIN2B

4.55e-0418332PF10613
DomainPBPe

GRIA4 GRIN2B

4.55e-0418332SM00079
DomainIono_rcpt_met

GRIA4 GRIN2B

4.55e-0418332IPR001508
DomainGlu/Gly-bd

GRIA4 GRIN2B

4.55e-0418332IPR019594
DomainLig_chan-Glu_bd

GRIA4 GRIN2B

4.55e-0418332SM00918
DomainCalcineurin-like_PHP_ApaH

PPP3CA PPP3CB

1.11e-0328332IPR004843
DomainMetallophos

PPP3CA PPP3CB

1.11e-0328332PF00149
DomainMetallo-depent_PP-like

PPP3CA PPP3CB

1.28e-0330332IPR029052
Domain-

PPP3CA PPP3CB

1.28e-03303323.60.21.10
DomainANF_receptor

GRIA4 GRIN2B

1.94e-0337332PF01094
DomainANF_lig-bd_rcpt

GRIA4 GRIN2B

1.94e-0337332IPR001828
DomainPeripla_BP_I

GRIA4 GRIN2B

2.15e-0339332IPR028082
DomainARM-type_fold

DOCK3 CLASP2 NCAPG2 USP9X

2.88e-03339334IPR016024
DomainHEAT

CLASP2 NCAPG2

3.25e-0348332PF02985
DomainHEAT

CLASP2 NCAPG2

4.70e-0358332IPR000357
DomainSAM_1

EPHB2 USH1G

6.41e-0368332PF00536
DomainSH3

DOCK3 NEDD9 TXK

6.45e-03216333PS50002
DomainSH3

DOCK3 NEDD9 TXK

6.45e-03216333SM00326
DomainSH3_domain

DOCK3 NEDD9 TXK

6.78e-03220333IPR001452
DomainHEAT_REPEAT

CLASP2 NCAPG2

6.78e-0370332PS50077
Domain-

CLASP2 NCAPG2 USP9X

6.95e-032223331.25.10.10
DomainTyrKc

EPHB2 TXK

1.05e-0288332SM00219
DomainTyr_kinase_cat_dom

EPHB2 TXK

1.05e-0288332IPR020635
DomainSAM

EPHB2 USH1G

1.05e-0288332SM00454
DomainARM-like

CLASP2 NCAPG2 USP9X

1.18e-02270333IPR011989
DomainSAM_DOMAIN

EPHB2 USH1G

1.22e-0295332PS50105
DomainPROTEIN_KINASE_TYR

EPHB2 TXK

1.27e-0297332PS00109
DomainSAM

EPHB2 USH1G

1.27e-0297332IPR001660
DomainTyr_kinase_AS

EPHB2 TXK

1.27e-0297332IPR008266
Domain-

EPHB2 USH1G

1.50e-021063321.10.150.50
PathwayBIOCARTA_NOS1_PATHWAY

GRIN2B PPP3CA PPP3CB

8.72e-0620293MM1445
PathwayBIOCARTA_NOS1_PATHWAY

GRIN2B PPP3CA PPP3CB

1.02e-0521293M11650
PathwayREACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_FYN

DOCK3 GRIN2B

8.53e-057292M27912
PathwayREACTOME_CALCINEURIN_ACTIVATES_NFAT

PPP3CA PPP3CB

1.46e-049292M27106
PathwayKEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS

GRIN2B PPP3CA PPP3CB

1.71e-0453293M3812
PathwayKEGG_MEDICUS_REFERENCE_LYSOSOMAL_CA2_RELEASE

PPP3CA PPP3CB

1.82e-0410292M47954
PathwayREACTOME_CALCINEURIN_ACTIVATES_NFAT

PPP3CA PPP3CB

2.22e-0411292MM14810
PathwayREACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION

PPP3CA PPP3CB

2.22e-0411292M27466
PathwayREACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION

PPP3CA PPP3CB TXK

2.24e-0458293MM14914
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_CN_SIGNALING_PATHWAY

PPP3CA PPP3CB

2.66e-0412292M47956
PathwayWP_MAPK_SIGNALING_PATHWAY

PTPN5 PPP3CA ACVR1B PPP3CB

3.04e-04160294MM15990
PathwayBIOCARTA_PGC1A_PATHWAY

PPP3CA PPP3CB

3.66e-0414292MM1473
PathwayKEGG_LONG_TERM_POTENTIATION

GRIN2B PPP3CA PPP3CB

3.91e-0470293M3115
PathwayBIOCARTA_PGC1A_PATHWAY

PPP3CA PPP3CB

4.22e-0415292M15181
PathwayBIOCARTA_NDKDYNAMIN_PATHWAY

PPP3CA PPP3CB

4.22e-0415292MM1387
PathwayWP_TRANSCRIPTIONAL_ACTIVATION_BY_NRF2_IN_RESPONSE_TO_PHYTOCHEMICALS

EPHB2 KEAP1

4.22e-0415292M39498
PathwayWP_ALZHEIMERS_DISEASE

GRIN2B PPP3CA PPP3CB

4.60e-0474293MM15962
PathwayBIOCARTA_MEF2D_PATHWAY

PPP3CA PPP3CB

4.82e-0416292MM1483
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_CALCINEURIN_SIGNALING_PATHWAY

PPP3CA PPP3CB

4.82e-0416292M47449
PathwayKEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAQ_PLCB_G_CALCINEURIN

PPP3CA PPP3CB

5.45e-0417292M47560
PathwayBIOCARTA_NDKDYNAMIN_PATHWAY

PPP3CA PPP3CB

5.45e-0417292M5940
PathwayWP_TRANSCRIPTIONAL_ACTIVATION_BY_NFE2L2_IN_RESPONSE_TO_PHYTOCHEMICALS

EPHB2 KEAP1

5.45e-0417292MM15891
PathwayBIOCARTA_CALCINEURIN_PATHWAY

PPP3CA PPP3CB

6.13e-0418292M3430
PathwayKEGG_MEDICUS_REFERENCE_BCR_PLCG_CALCINEURIN_SIGNALING_PATHWAY

PPP3CA PPP3CB

6.13e-0418292M47580
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_TRANSPORT_OF_CALCIUM

GRIN2B PRNP

6.13e-0418292M47761
PathwayBIOCARTA_MEF2D_PATHWAY

PPP3CA PPP3CB

6.13e-0418292M5290
PathwayBIOCARTA_CALCINEURIN_PATHWAY

PPP3CA PPP3CB

6.13e-0418292MM1385
PathwayWP_NRXN1_DELETION_SYNDROME

GRIA4 GRIN2B

6.13e-0418292M48098
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

PPP3CA PPP3CB

6.84e-0419292M47543
PathwayREACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION

PPP3CA PPP3CB TXK

7.14e-0486293M27206
PathwayWP_CALCIUM_MEDIATED_TCELL_APOPTOSIS_INVOLVED_IN_INCLUSION_BODY_MYOSITIS

PPP3CA PPP3CB

7.59e-0420292M48330
PathwayREACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES

GRIA4 GRIN2B

8.38e-0421292M27736
PathwayKEGG_MEDICUS_REFERENCE_CXCR4_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

PPP3CA PPP3CB

8.38e-0421292M47542
PathwayREACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION

GRIA4 GRIN2B

8.38e-0421292M838
PathwayWP_NRF2ARE_REGULATION

EPHB2 KEAP1

1.01e-0323292M39761
PathwayWP_PHYSIOLOGICAL_AND_PATHOLOGICAL_HYPERTROPHY_OF_THE_HEART

PPP3CA PPP3CB

1.10e-0324292M39576
PathwayREACTOME_DARPP_32_EVENTS

PPP3CA PPP3CB

1.10e-0324292M751
PathwayBIOCARTA_VIP_PATHWAY

PPP3CA PPP3CB

1.19e-0325292MM1441
PathwayREACTOME_SIGNALING_BY_NTRK2_TRKB

DOCK3 GRIN2B

1.19e-0325292M27864
PathwayBIOCARTA_HDAC_PATHWAY

PPP3CA PPP3CB

1.19e-0325292M1547
PathwayBIOCARTA_VIP_PATHWAY

PPP3CA PPP3CB

1.29e-0326292M17941
PathwayBIOCARTA_HDAC_PATHWAY

PPP3CA PPP3CB

1.29e-0326292MM1371
PathwayPID_TCR_CALCIUM_PATHWAY

PPP3CA PPP3CB

1.49e-0328292M235
PathwayBIOCARTA_GPCR_PATHWAY

PPP3CA PPP3CB

1.60e-0329292MM1495
PathwayBIOCARTA_GPCR_PATHWAY

PPP3CA PPP3CB

1.72e-0330292M9664
PathwayWP_FRAGILE_X_SYNDROME

PTPN5 GRIN2B PPP3CA

1.92e-03121293M39804
PathwayBIOCARTA_BCR_PATHWAY

PPP3CA PPP3CB

1.95e-0332292MM1355
PathwayPID_IL12_STAT4_PATHWAY

PPP3CA PPP3CB

1.95e-0332292M290
PathwayWP_INITIATION_OF_TRANSCRIPTION_AND_TRANSLATION_ELONGATION_AT_THE_HIV1_LTR

PPP3CA PPP3CB

1.95e-0332292M39521
PathwayBIOCARTA_BCR_PATHWAY

PPP3CA PPP3CB

2.07e-0333292M9494
PathwayBIOCARTA_FMLP_PATHWAY

PPP3CA PPP3CB

2.20e-0334292M10287
PathwayBIOCARTA_FMLP_PATHWAY

PPP3CA PPP3CB

2.20e-0334292MM1399
PathwayKEGG_AXON_GUIDANCE

EPHB2 PPP3CA PPP3CB

2.30e-03129293M5539
PathwayWP_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS

PPP3CA PPP3CB

2.74e-0338292M39357
PathwayPID_ERBB4_PATHWAY

GRIN2B ITCH

2.74e-0338292M13
PathwayBIOCARTA_FCER1_PATHWAY

PPP3CA PPP3CB

2.89e-0339292M1908
PathwayBIOCARTA_FCER1_PATHWAY

PPP3CA PPP3CB

2.89e-0339292MM1397
PathwayREACTOME_EPHB_MEDIATED_FORWARD_SIGNALING

EPHB2 GRIN2B

3.34e-0342292M27308
PathwayBIOCARTA_TCR_PATHWAY

PPP3CA PPP3CB

3.34e-0342292MM1504
PathwayREACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING

PPP3CA PPP3CB TXK

3.52e-03150293MM14889
PathwayBIOCARTA_TCR_PATHWAY

PPP3CA PPP3CB

3.66e-0344292M19784
PathwayREACTOME_CA2_PATHWAY

PPP3CA PPP3CB

3.83e-0345292MM15040
PathwaySIG_BCR_SIGNALING_PATHWAY

PPP3CA PPP3CB

4.00e-0346292M8626
PathwayWP_ENERGY_METABOLISM

PPP3CA PPP3CB

4.35e-0348292M39590
PathwayBIOCARTA_NFAT_PATHWAY

PPP3CA PPP3CB

4.53e-0349292MM1442
PathwayKEGG_ALZHEIMERS_DISEASE

GRIN2B PPP3CA PPP3CB

4.68e-03166293M16024
PathwayBIOCARTA_NFAT_PATHWAY

PPP3CA PPP3CB

4.89e-0351292M2288
PathwayPID_NFAT_3PATHWAY

PPP3CA PPP3CB

5.28e-0353292M113
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

EPHB2 CLASP2 GRIN2B PPP3CB PRNP

5.85e-03575295M29853
PathwayREACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING

PPP3CA PPP3CB TXK

6.42e-03186293M27175
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

EPHB2 HELZ2 CLASP2 GRIN2B ACVR1B PPP3CB RPTN PRNP

6.80e-031432298M509
PathwayREACTOME_CA2_PATHWAY

PPP3CA PPP3CB

7.16e-0362292M27321
PathwayPID_IL12_2PATHWAY

PPP3CA PPP3CB

7.16e-0362292M54
PathwayPID_BCR_5PATHWAY

PPP3CA PPP3CB

7.38e-0363292M10
Pubmed

Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure.

GRIN2B PPP3CA PPP3CB

5.75e-071734324086760
Pubmed

Coexpression of calcineurin A and B subunits in various subcellular and synaptic compartments of cerebellar neurons and glia with particular abundance at parallel fiber-Purkinje cell synapses.

PPP3CA PPP3CB

9.28e-07234235247520
Pubmed

The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses.

PPP3CA PPP3CB

9.28e-07234220810903
Pubmed

Calcineurin A-alpha but not A-beta is required for normal kidney development and function.

PPP3CA PPP3CB

9.28e-07234215509543
Pubmed

Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity.

PPP3CA PPP3CB

9.28e-07234219861587
Pubmed

Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors.

EPHB2 GRIN2B

9.28e-07234211799243
Pubmed

Inhibition of calcineurin phosphatase promotes exocytosis of renin from juxtaglomerular cells.

PPP3CA PPP3CB

9.28e-07234219907416
Pubmed

Chromosomal assignments of the genes for the calcineurin A alpha (Calna1) and A beta subunits (Calna2) in the rat.

PPP3CA PPP3CB

9.28e-0723428187553
Pubmed

Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase.

PPP3CA PPP3CB

9.28e-0723421328240
Pubmed

Overexpression of EphB2 in hippocampus rescues impaired NMDA receptors trafficking and cognitive dysfunction in Alzheimer model.

EPHB2 GRIN2B

9.28e-07234228358367
Pubmed

Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2.

PPP3CA PPP3CB

9.28e-07234211005320
Pubmed

Calcineurin expression and activity is regulated by the intracellular redox status and under hypertension in human neutrophils.

PPP3CA PPP3CB

9.28e-07234222739212
Pubmed

Are calcineurin genes associated with athletic status? A function, replication study.

PPP3CA PPP3CB

9.28e-07234221233773
Pubmed

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain.

PPP3CA PPP3CB

9.28e-0723422556704
Pubmed

Oxidation-induced conformational changes in calcineurin determined by covalent labeling and tandem mass spectrometry.

PPP3CA PPP3CB

9.28e-07234225286016
Pubmed

Prion protein is a key determinant of alcohol sensitivity through the modulation of N-methyl-D-aspartate receptor (NMDAR) activity.

GRIN2B PRNP

9.28e-07234222536327
Pubmed

Compensatory renal hypertrophy following uninephrectomy is calcineurin-independent.

PPP3CA PPP3CB

9.28e-07234225287476
Pubmed

Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs.

PPP3CA PPP3CB

2.78e-06334220700529
Pubmed

Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice.

PPP3CA PPP3CB

2.78e-06334212773574
Pubmed

Calcineurin protects the heart in a murine model of dilated cardiomyopathy.

PPP3CA PPP3CB

2.78e-06334219854199
Pubmed

Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively.

PPP3CA PPP3CB

2.78e-0633428978785
Pubmed

Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods.

PPP3CA PPP3CB

2.78e-0633422162844
Pubmed

Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha).

PPP3CA PPP3CB

2.78e-0633428392375
Pubmed

Tau binds both subunits of calcineurin, and binding is impaired by calmodulin.

PPP3CA PPP3CB

2.78e-06334218639592
Pubmed

Myospryn is a calcineurin-interacting protein that negatively modulates slow-fiber-type transformation and skeletal muscle regeneration.

PPP3CA PPP3CB

2.78e-06334221427212
Pubmed

The ubiquitin ligase itch is auto-ubiquitylated in vivo and in vitro but is protected from degradation by interacting with the deubiquitylating enzyme FAM/USP9X.

ITCH USP9X

2.78e-06334217038327
Pubmed

Calpain and STriatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model.

PTPN5 GRIN2B

2.78e-06334222523092
Pubmed

Calcineurin functions in Ca(2+)-activated cell death in mammalian cells.

PPP3CA PPP3CB

2.78e-0633427593193
Pubmed

Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes.

PPP3CA PPP3CB

2.78e-0633429655484
Pubmed

The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding.

PPP3CA PPP3CB

2.78e-06334219154138
Pubmed

Atrophin-1-interacting protein 4/human Itch is a ubiquitin E3 ligase for human enhancer of filamentation 1 in transforming growth factor-beta signaling pathways.

NEDD9 ITCH

2.78e-06334215051726
Pubmed

Rac activation and inactivation control plasticity of tumor cell movement.

DOCK3 NEDD9

2.78e-06334218984162
Pubmed

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin.

PPP3CA PPP3CB

2.78e-06334226794871
Pubmed

Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit.

PPP3CA PPP3CB

2.78e-0633421659808
Pubmed

Calcineurin signaling and PGC-1alpha expression are suppressed during muscle atrophy due to diabetes.

PPP3CA PPP3CB

2.78e-06334220359506
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

DOCK3 LRP2 OLFM1 GRIN2B ITCH PPP3CA PPP3CB USP9X AKAP8L

2.84e-06128534935914814
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

GRIA4 CLASP2 GRIN2B ITCH KEAP1 PPP3CA PPP3CB USP9X

3.21e-0696334828671696
Pubmed

Hippocampal Lnx1-NMDAR multiprotein complex mediates initial social memory.

EPHB2 GRIN2B

5.56e-06434231772302
Pubmed

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons.

GRIN2B PRNP

5.56e-06434222820466
Pubmed

Amyloid-β Receptors: The Good, the Bad, and the Prion Protein.

GRIA4 GRIN2B

5.56e-06434226719327
Pubmed

miR-23a is decreased during muscle atrophy by a mechanism that includes calcineurin signaling and exosome-mediated export.

PPP3CA PPP3CB

5.56e-06434224336651
Pubmed

Catalytic subunits of the phosphatase calcineurin interact with NF-κB-inducing kinase (NIK) and attenuate NIK-dependent gene expression.

PPP3CA PPP3CB

5.56e-06434226029823
Pubmed

Prion protein is essential for the RE1 silencing transcription factor (REST)-dependent developmental switch in synaptic NMDA receptors.

GRIN2B PRNP

5.56e-06434229748616
Pubmed

Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents.

PPP3CA PPP3CB

5.56e-06434219287093
Pubmed

Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life.

PPP3CA PPP3CB

5.56e-06434212809556
Pubmed

Molecular and phylogenetic analysis of calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit genes.

PPP3CA PPP3CB

5.56e-0643421318721
Pubmed

Lysosomal calcium signalling regulates autophagy through calcineurin and ​TFEB.

PPP3CA PPP3CB

5.56e-06434225720963
Pubmed

Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy.

PPP3CA PPP3CB

5.56e-06434215082723
Pubmed

Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61.

PTPN5 GRIN2B

5.56e-06434220427654
Pubmed

Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells.

PPP3CA PPP3CB

5.56e-06434211714752
Pubmed

Reciprocal regulation of the ubiquitin ligase Itch and the epidermal growth factor receptor signaling.

ITCH USP9X

5.56e-06434219341794
Pubmed

Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly.

EPHB2 PRNP

9.26e-06534226224839
Pubmed

Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity.

EPHB2 PRNP

9.26e-06534226589795
Pubmed

Calcineurin: form and function.

PPP3CA PPP3CB

9.26e-06534211015619
Pubmed

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex.

PPP3CA PPP3CB

9.26e-0653428524402
Pubmed

PSD-95 stabilizes NMDA receptors by inducing the degradation of STEP61.

PTPN5 GRIN2B

9.26e-06534227457929
Pubmed

Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults.

PPP3CA PPP3CB

9.26e-06534220593291
Pubmed

Elevated expression of calcineurin subunits during active mineralization of developing mouse molar teeth.

PPP3CA PPP3CB

9.26e-06534222984995
Pubmed

Developmental regulation of calcineurin isoforms in the rodent kidney: association with COX-2.

PPP3CA PPP3CB

9.26e-06534217881460
Pubmed

Calcineurin Links Mitochondrial Elongation with Energy Metabolism.

PPP3CA PPP3CB

9.26e-06534226411342
Pubmed

Are calcineurin genes associated with endurance phenotype traits?

PPP3CA PPP3CB

9.26e-06534220107831
Pubmed

[Expression profile of calcineurin pathway genes in myocardium tissues in relation to ischemic heart remodeling in humans].

PPP3CA PPP3CB

9.26e-06534223888774
Pubmed

Na(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy.

PPP3CA PPP3CB

9.26e-06534222688515
Pubmed

Mammalian brain phosphoproteins as substrates for calcineurin.

PPP3CA PPP3CB

1.39e-0563426330098
Pubmed

Vulnerability of white matter towards antenatal hypoxia is linked to a species-dependent regulation of glutamate receptor subunits.

GRIA4 GRIN2B

1.39e-05634218922769
Pubmed

Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D.

PPP3CA PPP3CB

1.39e-05634220647544
Pubmed

CIB1 is a regulator of pathological cardiac hypertrophy.

PPP3CA PPP3CB

1.39e-05634220639889
Pubmed

140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.

CLASP2 PPP3CA PPP3CB RAB33B

1.93e-0516334416512683
Pubmed

The protein serine/threonine phosphatases PP2A, PP1 and calcineurin: A triple threat in the regulation of the neuronal cytoskeleton.

PPP3CA PPP3CB

1.94e-05734228126489
Pubmed

Regulation of NMDA receptor trafficking by amyloid-beta.

PTPN5 GRIN2B

1.94e-05734216025111
Pubmed

Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity.

PPP3CA PPP3CB

1.94e-0573428631904
Pubmed

Low affinity Ca2+-binding sites of calcineurin B mediate conformational changes in calcineurin A.

PPP3CA PPP3CB

1.94e-05734211123943
Pubmed

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.

HBS1L ITCH KEAP1 PPP3CA NCAPG2 MRPS2

2.38e-0560434638803224
Pubmed

AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling.

PPP3CA PPP3CB

2.59e-05834217640527
Pubmed

Transmembrane topology of the glutamate receptor subunit GluR6.

GRIA4 GRIN2B

2.59e-0583428163463
Pubmed

Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling.

PPP3CA PPP3CB

3.33e-05934222343722
Pubmed

Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data.

GRIA4 GRIN2B

3.33e-05934234100982
Pubmed

Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.

PPP3CA PPP3CB

3.33e-05934211114196
Pubmed

The Cellular Phase of Alzheimer's Disease.

EPHB2 PRNP

3.33e-05934226871627
Pubmed

SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice.

PPP3CA PPP3CB

3.33e-05934234446558
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

LRP2 ACVR1B EPG5

4.66e-057134333541421
Pubmed

Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins.

PPP3CA PPP3CB

5.07e-051134211842093
Pubmed

USP9X-mediated deubiquitination of B-cell CLL/lymphoma 9 potentiates Wnt signaling and promotes breast carcinogenesis.

EPPK1 USP9X

5.07e-051134231073027
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

HBS1L CLASP2 KEAP1 PPP3CA

5.10e-0520934436779422
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

DOCK3 NEDD9 DMTF1 EPPK1 KEAP1

5.84e-0543034535044719
Pubmed

A reassessment of the inhibitory capacity of human FKBP38 on calcineurin.

PPP3CA PPP3CB

6.08e-051234215757646
Pubmed

Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding.

PPP3CA PPP3CB

6.08e-051234224905733
Pubmed

Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.

GRIA4 GRIN2B

7.19e-051334220859245
Pubmed

Deletion of olfactomedin 2 induces changes in the AMPA receptor complex and impairs visual, olfactory, and motor functions in mice.

OLFM1 GRIA4

7.19e-051334225218043
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

KEAP1 PPP3CB MRPS2 AKAP8L RBM10

8.20e-0546234531138677
Pubmed

Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions.

PPP3CA PPP3CB

8.38e-051434228826478
Pubmed

Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling.

EPHB2 KEAP1

9.66e-051534236963288
Pubmed

Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients.

PPP3CA PPP3CB

9.66e-051534221047202
Pubmed

Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+.

GRIA4 GRIN2B

9.66e-05153429481670
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

DOCK3 OLFM1 GRIA4 GRIN2B USP9X AKAP8L PRNP

9.83e-05113934736417873
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

GRIA4 GRIN2B PPP3CA PPP3CB

1.04e-0425134427507650
Pubmed

Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study.

NEDD9 PRNP

1.25e-041734220413850
Pubmed

A strategy for modulation of enzymes in the ubiquitin system.

ITCH USP9X

1.25e-041734223287719
Pubmed

JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse.

CLASP2 GRIN2B

1.25e-041734226627310
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

GRIN2B PPP3CA PPP3CB USP9X

1.60e-0428134428706196
InteractionDLG4 interactions

PTPN5 DOCK3 LRP2 GRIA4 GRIN2B PPP3CA PPP3CB PRNP

4.86e-07449338int:DLG4
InteractionGRB10 interactions

PPP3CA PPP3CB USP9X AKAP8L TXK

6.06e-06161335int:GRB10
InteractionTMEM200A interactions

PPP3CA ACVR1B PPP3CB

4.40e-0542333int:TMEM200A
InteractionTNS4 interactions

PPP3CA PPP3CB TXK

5.06e-0544333int:TNS4
GeneFamilyProtein phosphatase catalytic subunits|EF-hand domain containing

PPP3CA PPP3CB

1.20e-0413232693
GeneFamilySterile alpha motif domain containing

EPHB2 USH1G

5.54e-0388232760
DrugHemicholinium bromide [312-45-8]; Down 200; 7uM; MCF7; HT_HG-U133A

EPHB2 NEDD9 LRP2 FCF1 ITCH

1.05e-051973453216_DN
DrugSB 202190; Up 200; 1uM; MCF7; HT_HG-U133A

BRINP2 DMTF1 CLASP2 EPPK1 ACVR1B

1.07e-051983456909_UP
DiseaseHepatic Form of Wilson Disease

PPP3CA PPP3CB PRNP

2.54e-0624333C1527352
DiseaseHepatolenticular Degeneration

PPP3CA PPP3CB PRNP

2.54e-0624333C0019202
Diseasefocal segmental glomerulosclerosis (is_marker_for)

PPP3CA PPP3CB

3.38e-058332DOID:1312 (is_marker_for)
DiseaseMalignant neoplasm of prostate

EPHB2 LRP2 OLFM1 KEAP1 PPP3CA PRNP

5.54e-05616336C0376358
Diseaseschizophrenia (biomarker_via_orthology)

GRIN2B PPP3CB

1.26e-0415332DOID:5419 (biomarker_via_orthology)
DiseaseProstatic Neoplasms

LRP2 OLFM1 KEAP1 PPP3CA PRNP

5.71e-04616335C0033578
DiseaseAbnormality of refraction

EPHB2 PTPN5 DOCK3 GRIA4 GRIN2B

8.50e-04673335HP_0000539
Diseaseneutrophil measurement

OLFM1 HBS1L EPPK1

1.01e-03177333EFO_0803548
Diseaseejection fraction measurement

GRIA4 PPP3CA

1.06e-0343332EFO_0005527
Diseaseschizophrenia (is_marker_for)

PPP3CA PPP3CB

1.11e-0344332DOID:5419 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
MNDQYHRAARDGYLE

USH1G

1

Q495M9
FSYHRYQRVEMNENA

EPG5

346

Q9HCE0
RCYGYMERHINEIRT

NEDD9

436

Q14511
YHQRVYHNRQRLDME

ACVR1B

151

P36896
YRRVLRMYDDRNHVG

DMTF1

211

Q9Y222
YDAYRDQFRMRGNDT

AKAP8L

161

Q9ULX6
GGENRSRDHDYRDMD

RBM10

26

P98175
GQERFRKSMVQHYYR

RAB33B

91

Q9H082
MNYEGARSERENHAA

PTPN5

1

P54829
MARHRNVRGYNYDED

HBS1L

1

Q9Y450
YLADMNYVHRDLAAR

EPHB2

736

P29323
VQFDHYGRRVNYTMD

GRIA4

361

P48058
RVWYMDGYHNNRFVR

OLFM1

261

Q99784
DGYHNNRFVREYKSM

OLFM1

266

Q99784
YMDFCDYNGHHRRQV

LRP2

1621

P98164
RRVDNMGRIYYVDHF

ITCH

366

Q96J02
RGHDYERLEAFQQRM

DOCK3

1376

Q8IZD9
NHRYNIERMPDDYGA

FCF1

181

Q9Y324
QRAREYIYMHFGEVA

KEAP1

201

Q14145
NYRQRMHQFLYEEEA

HELZ2

341

Q9BYK8
IIRAHEAQDAGYRMY

PPP3CB

286

P16298
HEAQDAGYRMYRKSQ

PPP3CA

281

Q08209
SMRLYARDHEDYDPQ

USP9X

626

Q93008
VAYRRGYFDEEMNRV

EPPK1

2361

P58107
VAYRRGYFDEEMNRV

EPPK1

4496

P58107
ENMARDCGEYAHTRY

MRPS2

156

Q9Y399
HRAQEYADFMERYRQ

BRINP2

66

Q9C0B6
MNHAAARRFYQYAHE

NCAPG2

546

Q86XI2
RRRYESYGMHSDDDA

CLASP2

611

O75122
YRRHERIHMGEKAYQ

ZNF440

271

Q8IYI8
EDRYYRENMHRYPNQ

PRNP

146

P04156
EGMEYLERNGYIHRD

TXK

376

P42681
REACRDQMEGYHYRY

TPBGL

341

P0DKB5
MDRKGQCYHYDQTNR

RPTN

346

Q6XPR3
EYNHRGYTEERNPMN

ZNF487

246

B1APH4
TERNIRNNYAEMHAY

GRIN2B

691

Q13224