Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunction1-phosphatidylinositol-4-phosphate 3-kinase activity

PIK3C2G PIK3CA

6.60e-057362GO:0035005
GeneOntologyMolecularFunctionnuclear receptor activity

HNF4A HNF4G ESRRA

1.72e-0460363GO:0004879
GeneOntologyMolecularFunction1-phosphatidylinositol-3-kinase activity

PIK3C2G PIK3CA

1.72e-0411362GO:0016303
GeneOntologyMolecularFunctionligand-activated transcription factor activity

HNF4A HNF4G ESRRA

1.80e-0461363GO:0098531
GeneOntologyMolecularFunctionco-SMAD binding

USP9Y USP9X

2.06e-0412362GO:0070410
GeneOntologyMolecularFunctionphosphatidylinositol kinase activity

PIK3C2G PIK3CA

9.99e-0426362GO:0052742
GeneOntologyMolecularFunctionATP hydrolysis activity

SHOC1 ATP13A3 ASCC3 ATP2A2 DNAH11

1.10e-03441365GO:0016887
GeneOntologyMolecularFunctionP-type transmembrane transporter activity

ATP13A3 ATP2A2

1.92e-0336362GO:0140358
GeneOntologyMolecularFunctionP-type ion transporter activity

ATP13A3 ATP2A2

1.92e-0336362GO:0015662
GeneOntologyMolecularFunctionlipid kinase activity

PIK3C2G PIK3CA

2.48e-0341362GO:0001727
GeneOntologyCellularComponentintercalated disc

DSP ATP2A2 PIK3CA

2.18e-0468363GO:0014704
GeneOntologyCellularComponentcell-cell contact zone

DSP ATP2A2 PIK3CA

5.65e-0494363GO:0044291
GeneOntologyCellularComponentDNA repair complex

ASCC3 PALB2

7.13e-0423362GO:1990391
GeneOntologyCellularComponentphosphatidylinositol 3-kinase complex

PIK3C2G PIK3CA

1.14e-0329362GO:0005942
GeneOntologyCellularComponentanchoring junction

FOCAD ITGA1 GJB7 DSP ATP2A2 PIK3CA DSTYK

1.20e-03976367GO:0070161
MousePhenodelayed gastrulation

HNF4A USP9X

2.49e-054292MP:0012105
DomainARM-type_fold

FOCAD ARFGEF3 USP9Y TEX10 PIK3C2G GCN1 PIK3CA UNC45B USP9X

6.76e-09339349IPR016024
DomainRetinoid-X_rcpt/HNF4

HNF4A HNF4G ESRRA

6.56e-0710343IPR000003
DomainCOUP_TF

HNF4A HNF4G

3.21e-055342IPR003068
DomainPI3K_Ras-bd_dom

PIK3C2G PIK3CA

6.72e-057342IPR000341
DomainPI3K_RBD

PIK3C2G PIK3CA

6.72e-057342PS51546
DomainPI3K_rbd

PIK3C2G PIK3CA

6.72e-057342SM00144
DomainPI3K_rbd

PIK3C2G PIK3CA

6.72e-057342PF00794
Domainzf-C4

HNF4A HNF4G ESRRA

7.93e-0546343PF00105
DomainNUCLEAR_REC_DBD_1

HNF4A HNF4G ESRRA

7.93e-0546343PS00031
DomainZnf_hrmn_rcpt

HNF4A HNF4G ESRRA

7.93e-0546343IPR001628
DomainNuclear_hrmn_rcpt

HNF4A HNF4G ESRRA

7.93e-0546343IPR001723
DomainZnF_C4

HNF4A HNF4G ESRRA

7.93e-0546343SM00399
DomainNUCLEAR_REC_DBD_2

HNF4A HNF4G ESRRA

7.93e-0546343PS51030
Domain-

HNF4A HNF4G ESRRA

8.46e-05473431.10.565.10
DomainPI3K_C2_dom

PIK3C2G PIK3CA

8.95e-058342IPR002420
DomainPI3K_C2

PIK3C2G PIK3CA

8.95e-058342PS51547
DomainPI3K_C2

PIK3C2G PIK3CA

8.95e-058342SM00142
DomainPI3K_C2

PIK3C2G PIK3CA

8.95e-058342PF00792
DomainHOLI

HNF4A HNF4G ESRRA

9.01e-0548343SM00430
DomainNucl_hrmn_rcpt_lig-bd

HNF4A HNF4G ESRRA

9.01e-0548343IPR000536
DomainHormone_recep

HNF4A HNF4G ESRRA

9.01e-0548343PF00104
DomainPI3Ka

PIK3C2G PIK3CA

1.15e-049342PF00613
Domain-

PIK3C2G PIK3CA

1.15e-0493421.25.40.70
DomainPI3Ka

PIK3C2G PIK3CA

1.15e-049342SM00145
DomainARM-like

USP9Y TEX10 GCN1 UNC45B USP9X

1.20e-04270345IPR011989
DomainPIK_HELICAL

PIK3C2G PIK3CA

1.43e-0410342PS51545
DomainPI_Kinase

PIK3C2G PIK3CA

1.43e-0410342IPR015433
DomainPInositide-3_kin_accessory_dom

PIK3C2G PIK3CA

1.43e-0410342IPR001263
Domain-

HNF4A HNF4G ESRRA

1.51e-04573433.30.50.10
DomainZnf_NHR/GATA

HNF4A HNF4G ESRRA

1.59e-0458343IPR013088
DomainPI3/4_kinase_CS

PIK3C2G PIK3CA

3.33e-0415342IPR018936
DomainPI3Kc

PIK3C2G PIK3CA

3.80e-0416342SM00146
Domain-

PIK3C2G PIK3CA

3.80e-04163421.10.1070.11
DomainHEAT_type_2

TEX10 GCN1

4.30e-0417342IPR021133
DomainATPase_P-typ_cation-transptr_C

ATP13A3 ATP2A2

4.30e-0417342IPR006068
DomainCation_ATPase_C

ATP13A3 ATP2A2

4.30e-0417342PF00689
DomainPI3_4_KINASE_1

PIK3C2G PIK3CA

4.83e-0418342PS00915
DomainPI3_4_KINASE_2

PIK3C2G PIK3CA

4.83e-0418342PS00916
DomainPI3/4_kinase_cat_dom

PIK3C2G PIK3CA

4.83e-0418342IPR000403
DomainCation_ATPase_N

ATP13A3 ATP2A2

4.83e-0418342PF00690
DomainPI3_PI4_kinase

PIK3C2G PIK3CA

4.83e-0418342PF00454
DomainPI3_4_KINASE_3

PIK3C2G PIK3CA

4.83e-0418342PS50290
DomainATPase_P-typ_cation-transptr_N

ATP13A3 ATP2A2

5.39e-0419342IPR004014
Domain-

TEX10 GCN1 UNC45B USP9X

6.81e-042223441.25.10.10
Domain-

ATP13A3 ATP2A2

1.54e-03323422.70.150.10
Domain-

ATP13A3 ATP2A2

1.54e-03323423.40.1110.10
DomainATPase_P-typ_cyto_domN

ATP13A3 ATP2A2

1.84e-0335342IPR023299
DomainATPase_P-typ_P_site

ATP13A3 ATP2A2

1.95e-0336342IPR018303
DomainP_typ_ATPase

ATP13A3 ATP2A2

1.95e-0336342IPR001757
DomainATPASE_E1_E2

ATP13A3 ATP2A2

1.95e-0336342PS00154
DomainATPase_P-typ_transduc_dom_A

ATP13A3 ATP2A2

2.06e-0337342IPR008250
DomainE1-E2_ATPase

ATP13A3 ATP2A2

2.06e-0337342PF00122
DomainARM

GCN1 UNC45B

2.40e-0340342SM00185
Domain-

ASCC3 PIK3C2G PIK3CA

2.44e-031483432.60.40.150
DomainC2_dom

ASCC3 PIK3C2G PIK3CA

3.26e-03164343IPR000008
DomainArmadillo

GCN1 UNC45B

3.30e-0347342IPR000225
DomainHEAT

TEX10 GCN1

3.44e-0348342PF02985
DomainHEAT

TEX10 GCN1

4.99e-0358342IPR000357
DomainUSP_CS

USP9Y USP9X

6.41e-0366342IPR018200
DomainHEAT_REPEAT

TEX10 GCN1

7.19e-0370342PS50077
DomainUSP_1

USP9Y USP9X

7.19e-0370342PS00972
PathwayREACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY

HNF4A HNF4G ESRRA

9.61e-0553243M8276
PathwayKEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC

ITGA1 DSP ATP2A2

2.60e-0474243M16376
PathwayWP_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY

ITGA1 DSP ATP2A2

2.60e-0474243M39462
PathwayREACTOME_PHOSPHOLIPID_METABOLISM

PIK3C2G PIK3CA DGAT1 GNPAT

3.10e-04196244MM14591
PathwayBIOCARTA_BCELLSURVIVAL_PATHWAY

ITGA1 PIK3CA

3.72e-0417242MM1353
PathwayREACTOME_PHOSPHOLIPID_METABOLISM

PIK3C2G PIK3CA DGAT1 GNPAT

4.10e-04211244M649
PathwayWP_CONGENITAL_GENERALIZED_LIPODYSTROPHY

PIK3CA DGAT1

4.18e-0418242M42546
PathwayBIOCARTA_CXCR4_PATHWAY

PIK3C2G PIK3CA

4.67e-0419242MM1375
PathwayBIOCARTA_CXCR4_PATHWAY

PIK3C2G PIK3CA

4.67e-0419242M882
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS

HNF4A HNF4G

5.72e-0421242M14966
PathwayBIOCARTA_ECM_PATHWAY

ITGA1 PIK3CA

5.72e-0421242MM1390
PathwayWP_TRIACYLGLYCERIDE_SYNTHESIS

DGAT1 GNPAT

6.88e-0423242MM15890
PathwayWP_TRIACYLGLYCERIDE_SYNTHESIS

DGAT1 GNPAT

7.49e-0424242M39692
PathwayPID_LYMPH_ANGIOGENESIS_PATHWAY

ITGA1 PIK3CA

8.14e-0425242M274
PathwayKEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG

HNF4A HNF4G

8.14e-0425242M18312
Pubmed

Three-dimensional interactions between enhancers and promoters during intestinal differentiation depend upon HNF4.

HNF4A HNF4G

1.04e-06236233503426
Pubmed

Intestine-specific ablation of the Hepatocyte Nuclear Factor 4a (Hnf4a) gene in mice has minimal impact on serum lipids and ileum gene expression profile due to upregulation of its paralog Hnf4g.

HNF4A HNF4G

1.04e-06236234973414
Pubmed

Proteomic analysis of native hepatocyte nuclear factor-4α (HNF4α) isoforms, phosphorylation status, and interactive cofactors.

HNF4A HNF4G

1.04e-06236221047794
Pubmed

Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids.

HNF4A HNF4G

1.04e-06236212220494
Pubmed

Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes.

HNF4A HNF4G

1.04e-0623628622695
Pubmed

DGAT1 participates in the effect of HNF4A on hepatic secretion of triglyceride-rich lipoproteins.

HNF4A DGAT1

1.04e-06236220167659
Pubmed

Induction of Hepatic Metabolic Functions by a Novel Variant of Hepatocyte Nuclear Factor 4γ.

HNF4A HNF4G

1.04e-06236230224520
Pubmed

The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2.

USP9Y USP9X

1.04e-0623628922996
Pubmed

Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.

USP9Y USP9X

1.04e-06236212925892
Pubmed

Glucose Tolerance Is Improved in Mice Invalidated for the Nuclear Receptor HNF-4γ: A Critical Role for Enteroendocrine Cell Lineage.

HNF4A HNF4G

1.04e-06236225829452
Pubmed

Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome.

USP9Y USP9X

1.04e-06236212895410
Pubmed

A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity.

HNF4A HNF4G

3.12e-06336230988513
Pubmed

The nuclear receptor HNF4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac.

HNF4A HNF4G

3.12e-06336234001900
Pubmed

Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha.

HNF4A ESRRA

3.12e-06336219389810
Pubmed

The calcium ATPase SERCA2 regulates desmoplakin dynamics and intercellular adhesive strength through modulation of PKCα signaling.

DSP ATP2A2

3.12e-06336221156808
Pubmed

Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers.

HNF4A HNF4G

6.24e-06436212544512
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

BRD8 ASCC3 TEX10 GCN1 USP9X

1.04e-0528236523667531
Pubmed

MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes.

HNF4A HNF4G

1.04e-05536236924494
Pubmed

High prevalence of respiratory ciliary dysfunction in congenital heart disease patients with heterotaxy.

CCDC40 DNAH11

1.04e-05536222499950
Pubmed

Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.

HNF4A HNF4G ESRRA GNPAT

1.09e-0513336415604093
Pubmed

Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus.

HNF4A HNF4G

1.56e-05636237399024
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

ARFGEF3 HNF4A DSP USP9X DSTYK DNAH11

2.02e-0555236610737800
Pubmed

GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells.

HNF4A HNF4G

2.18e-05736222554936
Pubmed

Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice.

ATP2A2 ESRRA

3.73e-05936234029594
Pubmed

Gut microbial fatty acid isomerization modulates intraepithelial T cells.

HNF4A HNF4G

3.73e-05936237380774
Pubmed

Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.

ARFGEF3 ATP2A2 GCN1 USP9X

3.83e-0518336423956138
Pubmed

The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1.

PIK3C2G PIK3CA

4.66e-05103628636073
Pubmed

Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells.

PIK3C2G PIK3CA

4.66e-05103628798481
Pubmed

Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells.

ARFGEF3 PIK3CA

4.66e-051036224051437
Pubmed

Expression of HIV-1 nef decreases basal phosphatidyl-inositol 3-kinase activity.

PIK3C2G PIK3CA

4.66e-05103629247029
Pubmed

Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene.

USP9Y USP9X

4.66e-05103629384609
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

ASCC3 TEX10 DSP ATP2A2 GCN1 USP9X

5.16e-0565336622586326
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

ASCC3 DSP ATP2A2 GCN1

5.62e-0520236433005030
Pubmed

HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells.

PIK3C2G PIK3CA

5.70e-05113629708406
Pubmed

HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line.

PIK3C2G PIK3CA

5.70e-051136210985305
Pubmed

Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells.

PIK3C2G PIK3CA

5.70e-051136212584329
Pubmed

Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity.

PIK3C2G PIK3CA

5.70e-05113629808187
Pubmed

Hepatocyte nuclear factor 4alpha contributes to an intestinal epithelial phenotype in vitro and plays a partial role in mouse intestinal epithelium differentiation.

HNF4A HNF4G

5.70e-051136219389805
Pubmed

HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways.

PIK3C2G PIK3CA

5.70e-051136216081599
Pubmed

Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis.

USP9Y USP9X

6.83e-051236223861879
Pubmed

HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation: dissociation of the CD4-p56(lck) complex and targeting of CD4 to lysosomes.

PIK3C2G PIK3CA

6.83e-051236210208934
Pubmed

Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells.

PIK3C2G PIK3CA

6.83e-051236214602571
Pubmed

Colony-stimulating factor-1 requires PI3-kinase-mediated metabolism for proliferation and survival in myeloid cells.

PIK3C2G PIK3CA

6.83e-051236216514418
Pubmed

Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism.

PIK3C2G PIK3CA

6.83e-051236212077252
Pubmed

Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity.

PIK3C2G PIK3CA

6.83e-05123629341793
Pubmed

MRG15 is a novel PALB2-interacting factor involved in homologous recombination.

BRD8 PALB2

6.83e-051236219553677
Pubmed

Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages.

PIK3C2G PIK3CA

6.83e-051236212551992
Pubmed

Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved.

ATP2A2 GCN1 USP9X GNPAT

7.42e-0521736430619736
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

CTNNAL1 ASCC3 DSP ATP2A2 GCN1 USP9X

8.06e-0570836639231216
Pubmed

HIV-1 Nef in macrophage-mediated disease pathogenesis.

PIK3C2G PIK3CA

8.07e-051336223215766
Pubmed

Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells.

PIK3C2G PIK3CA

8.07e-05133629394803
Pubmed

Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line.

PIK3C2G PIK3CA

9.41e-051436217157319
Pubmed

Deubiquitinating enzymes: a new class of biological regulators.

USP9Y USP9X

1.08e-04153629827704
Pubmed

HIV Nef enhances Tat-mediated viral transcription through a hnRNP-K-nucleated signaling complex.

PIK3C2G PIK3CA

1.08e-041536218854243
Pubmed

Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.

USP9Y USP9X

1.08e-041536214762062
Pubmed

HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45.

PIK3C2G PIK3CA

1.24e-041636216524887
Pubmed

Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders.

PIK3C2G PIK3CA

1.24e-041636220818790
Pubmed

HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway.

PIK3C2G PIK3CA

1.24e-041636211289809
Pubmed

Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice.

PIK3C2G PIK3CA

1.24e-041636220019835
Pubmed

Akt/Nox2/NF-κB signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation.

PIK3C2G PIK3CA

1.24e-041636221029719
Pubmed

Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes.

PIK3C2G PIK3CA

1.40e-041736223251686
Pubmed

Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.

PIK3C2G PIK3CA

1.40e-041736212960231
Pubmed

Signaling mechanism of HIV-1 gp120 and virion-induced IL-1beta release in primary human macrophages.

PIK3C2G PIK3CA

1.40e-041736218453587
Pubmed

A strategy for modulation of enzymes in the ubiquitin system.

USP9Y USP9X

1.40e-041736223287719
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

ASCC3 USP9Y TEX10 IGKV4-1 USP9X

1.53e-0449736536774506
Pubmed

HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway.

PIK3C2G PIK3CA

1.58e-041836212526811
Pubmed

Sex differences in sex chromosome gene expression in mouse brain.

USP9Y USP9X

1.58e-041836212023983
Pubmed

HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine.

HNF4A HNF4G

1.76e-041936231345929
Pubmed

HIV-1 Tat protein induces the production of IDO in human monocyte derived-dendritic cells through a direct mechanism: effect on T cells proliferation.

PIK3C2G PIK3CA

1.76e-041936224073214
Pubmed

Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.

FOCAD KCNK12 GJB7 ASCC3 ACER3 PALB2

1.94e-0483236636724073
Pubmed

Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.

PIK3C2G PIK3CA

2.16e-04213629446795
Pubmed

HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells.

PIK3C2G PIK3CA

2.38e-042236211994280
Pubmed

A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.

HNF4G ESRRA

2.38e-042236223975195
Pubmed

HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes.

PIK3C2G PIK3CA

2.38e-042236211154208
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

BRD8 ASCC3 DSP GCN1 USP9X

2.42e-0454936538280479
Pubmed

A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.

HNF4A HNF4G ESRRA

2.50e-0411836316971476
Pubmed

HIV-1 Tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3β signaling pathway.

PIK3C2G PIK3CA

2.60e-042336223301033
Pubmed

Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia.

PIK3C2G PIK3CA

2.60e-042336219047410
Pubmed

MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks.

BRD8 PALB2

2.60e-042336220332121
Pubmed

Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway.

BRD8 PALB2

2.60e-042336222038470
Pubmed

Distinct roles of androgen receptor, estrogen receptor alpha, and BCL6 in the establishment of sex-biased DNA methylation in mouse liver.

HNF4A ESRRA

2.83e-042436234215813
Pubmed

Quantitative interactome proteomics identifies a proteostasis network for GABAA receptors.

ATP2A2 GCN1 USP9X

2.97e-0412536336030824
Pubmed

Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120.

PIK3C2G PIK3CA

3.08e-042536215689238
Pubmed

Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy.

PIK3C2G PIK3CA

3.08e-042536217632570
Pubmed

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

DSP ATP2A2 GCN1 USP9X

3.28e-0432036428685749
Pubmed

Deletion of Pdcd5 in mice led to the deficiency of placenta development and embryonic lethality.

HNF4A PIK3CA

3.60e-042736228542142
Pubmed

HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.

PIK3C2G PIK3CA

3.60e-042736211156964
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

ARFGEF3 ASCC3 TEX10 ATP2A2 GCN1 USP9X

3.78e-0494236631073040
Pubmed

RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.

FOCAD ATP2A2 GCN1 USP9X

4.32e-0434436436282215
Pubmed

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.

ASCC3 DSP ATP2A2 GCN1

4.96e-0435736437059091
Pubmed

Primary Ciliary Dyskinesia

CCDC40 DNAH11

5.07e-043236220301301
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

ASCC3 TEX10 DSP ATP2A2 GCN1 USP9X

5.87e-04102436624711643
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

CTNNAL1 TEX10 DSP ATP2A2 GCN1 USP9X

6.66e-04104936627880917
Pubmed

Interactome profiling reveals interaction of SARS-CoV-2 NSP13 with host factor STAT1 to suppress interferon signaling.

ATP2A2 GCN1 USP9X

6.79e-0416636334687317
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

BRD8 USP9X ESRRA

6.91e-0416736320362541
Pubmed

Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.

ASCC3 GCN1 USP9X

7.15e-0416936331462741
Pubmed

Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase.

ASCC3 USP9X

7.54e-043936225944111
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

ASCC3 DSP GCN1 PALB2

8.94e-0441836434709266
Pubmed

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

USP9Y ATP2A2 GCN1 USP9X

1.01e-0343236423455922
InteractionNPTN interactions

FOCAD ARFGEF3 ATP2A2 GCN1 DSTYK GNPAT

7.57e-06278356int:NPTN
InteractionPNRC2 interactions

HNF4A HNF4G ESRRA

3.02e-0535353int:PNRC2
InteractionIL13RA2 interactions

GCN1 PIK3CA PALB2 TMED4

8.83e-05136354int:IL13RA2
InteractionHDAC5 interactions

HNF4A DSP ATP2A2 GCN1 USP9X ESRRA

8.98e-05432356int:HDAC5
InteractionSPPL3 interactions

FOCAD KCNK12 ATP13A3 GJB7 ASCC3 ACER3 SLC7A14 PALB2

1.10e-04886358int:SPPL3
InteractionCASP4 interactions

DSP GCN1 USP9X

1.12e-0454353int:CASP4
InteractionGPR182 interactions

FOCAD ARFGEF3 ATP13A3 GCN1 DGAT1 GNPAT

1.19e-04455356int:GPR182
InteractionGPR17 interactions

ARFGEF3 ATP13A3 ATP2A2 DSTYK DGAT1

1.21e-04283355int:GPR17
InteractionBRD8 interactions

BRD8 HNF4A UNC45B PALB2

1.26e-04149354int:BRD8
CytobandEnsembl 112 genes in cytogenetic band chr9q31

SHOC1 CTNNAL1 TEX10

1.73e-04137363chr9q31
GeneFamilyNuclear hormone receptors

HNF4A HNF4G ESRRA

3.19e-054923371
GeneFamilyPhosphatidylinositol 3-kinase subunits

PIK3C2G PIK3CA

4.31e-058232831
GeneFamilyUbiquitin specific peptidases

USP9Y USP9X

2.29e-0356232366
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

ARFGEF3 SLC7A14

2.20e-02181232694
ToppCellwk_15-18-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 HNF4A HNF4G DSP SLC7A14

3.10e-071833558820cfed27b292bc0bc9cde4005219ed41900552
ToppCellTCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma|TCGA-Cervix / Sample_Type by Project: Shred V9

ARFGEF3 HNF4A HNF4G CCDC40

9.40e-06170354d682178d11d67eb5a02d0c6b3967645e37bcc62a
ToppCellileum|World / shred on tissue and cell subclass

HNF4A HNF4G DSP DGAT1

9.40e-061703549f1211bd4287620e19a59f21e6ecdca3e42e0260
ToppCellTCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma-Mucinous_Adenocarcinoma|TCGA-Cervix / Sample_Type by Project: Shred V9

ARFGEF3 HNF4A HNF4G CCDC40

9.62e-061713541af575809b3334bfaa019ff26c56e6cb03c82ee8
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASCC3 ATP2A2 SLC7A14 USP9X

1.61e-051953543e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASCC3 ATP2A2 SLC7A14 USP9X

1.61e-051953547796ea9247f4c63762f0de8490fed08b9717fa23
ToppCelldistal-Hematologic-Platelet/Megakaryocyte-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GJB7 HNF4G DSP DNAH11

1.68e-05197354751ffb8792058384079ebfe94872b3525f1aea84
ToppCellBronchial_Brush-Epithelial|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

ARFGEF3 DSP ATP2A2 DNAH11

1.68e-05197354272c7f4e582ef57564450540242b0db766b78328
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HNF4A HNF4G DSP DGAT1

1.71e-05198354e3e2233c796d5e9051c8c1b66f70f406f048ed56
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HNF4A HNF4G DSP DGAT1

1.71e-05198354ecdef1a0a0b8399e193b922c8ca8c25e63de4a4f
ToppCell3'-Child09-12-SmallIntestine-Epithelial|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HNF4A HNF4G DSP DGAT1

1.75e-05199354043c65bdf54a1bf0e483fea9ffc042ff5b271764
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-TA|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HNF4A HNF4G DSP DGAT1

1.75e-05199354c9bd712cf401aec256a2cfaec5b580209e52c265
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-BMP_responsible_cell|6m / Sample Type, Dataset, Time_group, and Cell type.

FOCAD CTNNAL1 DSP CCDC40

1.78e-052003545fb90118d3abc28d72bc483e68317255090a04c7
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SHOC1 MARCHF11 GNPAT

1.06e-04117353240cd636d1f5d3f270825ace02126fae993f5802
ToppCellICU-SEP-Lymphocyte-T_NK-Treg|ICU-SEP / Disease, Lineage and Cell Type

PCNX2 FSIP2 KCNK12

1.99e-04145353ee99b58462f955b96d036aa67e343db047d66f64
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SHOC1 MARCHF11 PIK3C2G

2.03e-04146353e887e9de895fd453faa703997ef372cc6410fc49
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CTNNAL1 ESRRA DGAT1

2.24e-04151353c1461d0dd622a081187eba77f454d2663df2732e
ToppCellnormal_Pleural_Fluid-Myeloid_cells-Monocytes|Myeloid_cells / Location, Cell class and cell subclass

ATP13A3 CTNNAL1 USP9Y

2.42e-0415535385eb60d285b8bfc095c341ae90c0e3b7e7dca9c1
ToppCellCOVID-CD8-CD8_2|COVID / Condition, Cell_class and T cell subcluster

SHOC1 ITGA1 IGKV4-1

2.71e-04161353307dcc17475413cd9eb70c27bc447f938ee5723d
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma|TCGA-Brain / Sample_Type by Project: Shred V9

ARFGEF3 MARCHF11 SLC7A14

2.71e-041613535f6b2d7f80a8ee16651e304481d2da3fae313824
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BRD8 USP9Y PALB2

2.86e-0416435395ce619ebf0cf5716b099fdc71267313f9dc9d32
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BRD8 USP9Y PALB2

2.86e-04164353d0a7e8a7c530f8d7224b50f2abe3d3642fac142b
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARFGEF3 DSP SLC7A14

2.96e-04166353afba41e15478053f11815acf568d29187de75492
ToppCelllung-Ciliated_Epithelia|lung / shred on tissue and cell subclass

GJB7 CCDC40 DNAH11

3.01e-0416735326cf1cfa58ee74794449a87eb19cd896e1ec8892
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARFGEF3 DSP SLC7A14

3.07e-04168353f3164a85e5630ee8a745c6dba298e1f94ba4d5b8
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HNF4G PIK3C2G DNAH11

3.12e-0416935312bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellfacs-Marrow-T-cells-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA1 USP9Y ACER3

3.17e-04170353a78d9789c3e7c84a36e1bd380192d7aba4a4d443
ToppCellfacs-Marrow-T-cells-3m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA1 USP9Y ACER3

3.17e-04170353ff68600b945b3a5437b14e5411b3db800d0ccbe5
ToppCell3'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HNF4A HNF4G DSP

3.34e-0417335381c36b9fe02c59099f080b2db02f4eaf2783911f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP13A3 CCDC40 DNAH11

3.45e-04175353284fdc7a9d303636a637041846850d19d114861a
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HNF4A DSP DGAT1

3.45e-041753536759d200a133034756de9cdf2d5daceca927aac9
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARFGEF3 DSP SLC7A14

3.45e-04175353c031da47ca63d1133e13530cbf779df9435e22cb
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTNNAL1 PALB2 DNAH11

3.51e-041763533766e0533b103ec92ac75eba3df02e287efc53fa
ToppCellnormal_Lung-Endothelial_cells-EPCs|normal_Lung / Location, Cell class and cell subclass

CTNNAL1 ITGA1 SLC7A14

3.51e-0417635371d1bd425772d89d8c550b909e0ec0e36ff22a7e
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTNNAL1 PALB2 DNAH11

3.51e-04176353aa1bada2175d8370fc71939a607407155259d195
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Granulocytic-Mast_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KCNK12 ACER3 DNAH11

3.57e-0417735386c41d262142eeaa95ea7fa6668169eb1bb2953f
ToppCellAdult-Epithelial-lung_goblet_cell|Adult / Lineage, Cell type, age group and donor

ARFGEF3 HNF4G DSP

3.69e-041793531fc1f252ca943a2f649d1e627f56acbf15f8e058
ToppCellwk_20-22-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

MARCHF11 HNF4G DSP

3.69e-0417935306f92c884189197c86793191c05f65e34925c097
ToppCell15-Distal-Epithelial-Neuroendocrine|Distal / Age, Tissue, Lineage and Cell class

ARFGEF3 HNF4A SLC7A14

3.69e-04179353bc04789f0fbd293fdcea66acba8cf227af251b7a
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARFGEF3 DSP SLC7A14

3.75e-041803536b1606238417490e0d9930870a7827419d1c3737
ToppCelldroplet-Marrow-nan-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNK12 ITGA1 ACER3

3.87e-04182353bc8d621be57f76d718d9b0f11e023b0f4dcb668d
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-TA|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HNF4A HNF4G DSP

3.94e-041833530d21befacefc6c597e7b501ed41b7fe9385a78df
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARFGEF3 PIK3C2G DNAH11

4.00e-04184353ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARFGEF3 PIK3C2G DNAH11

4.00e-041843532cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARFGEF3 PIK3C2G DNAH11

4.00e-041843532b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSP ATP2A2 USP9X

4.06e-04185353eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARFGEF3 DSP SLC7A14

4.06e-04185353eb78614c4acf8d2ce7874d7e51e16997b76127ef
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 MARCHF11 HNF4G

4.19e-0418735398477ba04a42a8da80a72f41a182429f46283595
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

ATP13A3 ITGA1 USP9X

4.26e-04188353ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARFGEF3 ATP2A2 SLC7A14

4.26e-04188353a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

HNF4A PIK3C2G DSP

4.33e-041893535d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCellBac-SEP-Lymphocyte-B-Plasmablast|Bac-SEP / Disease, Lineage and Cell Type

KCNK12 CTNNAL1 IGKV4-1

4.33e-041893536339b6d1056e07cefb0e1b2a0e479913c5783c8a
ToppCellPCW_05-06-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 PIK3C2G DSP

4.33e-04189353c8b8f860aaf6c73863cd79941db6b469c830ef06
ToppCelldroplet-Marrow-nan-21m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNK12 ITGA1 ACER3

4.39e-041903536c6d3259e23ec90c08756f500ae8a7aff8b8a5b3
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 MARCHF11 HNF4G

4.39e-041903532375e604eacd38f61f3e661ba2f76d286fcceca7
ToppCellGlobus_pallidus-Neuronal|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

PCNX2 ARFGEF3 SLC7A14

4.39e-04190353416de85d8841dac883faa6f5339b2fb461a09e82
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 MARCHF11 HNF4G

4.39e-04190353b1095b2a7467c152d16e4f19a9515aeb61fc9e3d
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP2A2 SLC7A14 USP9X

4.46e-04191353f76f3f5c7902a3659d8cbe470f96ce57c8a6744d
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP2A2 SLC7A14 USP9X

4.46e-04191353fd01a206763dfb6d52cca67123571936b4a8e1a0
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

PCNX2 ARFGEF3 PIK3CA

4.46e-041913535d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCellEntopeduncular-Neuronal-Inhibitory|Entopeduncular / BrainAtlas - Mouse McCarroll V32

PCNX2 ARFGEF3 PIK3CA

4.46e-0419135373dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARFGEF3 ATP2A2 SLC7A14

4.46e-04191353a251b134f67a0a1ef3a42f50042f128a17f20b22
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARFGEF3 ATP2A2 SLC7A14

4.46e-041913533387b95a3f2445c672d407922fdce3a91eabaef8
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CTNNAL1 ITGA1 ACER3

4.46e-04191353a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCellCiliated-cil-3|World / Class top

KCNK12 CCDC40 DNAH11

4.53e-041923534989ebb8812b8af1870599acd932849122c05a29
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP2A2 SLC7A14 USP9X

4.53e-041923535b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

HNF4A PIK3C2G DSP

4.53e-04192353b7c01e12b3e9be960a741b08835f1dfff65d0d47
ToppCelldroplet-Lung-nan-18m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTNNAL1 ITGA1 UNC45B

4.53e-0419235345929c757d873fe314cc36d27abd265414635490
ToppCelldroplet-Pancreas-Endocrine-18m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP2A2 SLC7A14 USP9X

4.53e-041923534510aa262da8dcf7c944b3907a51aba5a9397a4e
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP2A2 SLC7A14 USP9X

4.53e-041923531304e69c92cef3bd8c82e3c035a7562f5440139a
ToppCellfacs-Lung-nan-3m-Epithelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARFGEF3 ATP13A3 DSP

4.53e-04192353cca2d0fedfbd946c54d6f4fc45887117c8dae58a
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARFGEF3 DSP SLC7A14

4.53e-041923535692bd57093852d442400383850f416c497dcc7d
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARFGEF3 DSP SLC7A14

4.53e-041923530b506fb5bca54a50949932293c6f86d974a3acdd
ToppCelldroplet-Pancreas-Endocrine|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP2A2 SLC7A14 USP9X

4.53e-041923530dfd1e9896c34aee0f842f8de5d0e3af62a15f68
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3C2G DSP TMED4

4.53e-04192353967122c53af25b8f19a8411b4553d764c8d51c4d
ToppCelldroplet-Lung-nan-18m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTNNAL1 ITGA1 UNC45B

4.53e-04192353beb336d3479821bdab7e8e2c58812f155e44e9a2
ToppCellhuman_hepatoblastoma-Tumor_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

HNF4A HNF4G DSP

4.60e-04193353503a979328c68b096680b71359a26f02fafdff35
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HNF4A DSP DGAT1

4.60e-0419335332eb026d4317c1499d51294d396dfd5f293f9deb
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic-Colonocyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HNF4A DSP DGAT1

4.60e-04193353930df79b0600f43617052313294be33bcf5631f0
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

HNF4A PIK3C2G DSP

4.60e-041933534b8202fcfe639a73f69a13f48fc3601ade256346
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HNF4A DSP DGAT1

4.67e-0419435307d8e38cbc2c7f0564c14f7c365f345f901b73b2
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SHOC1 CCDC40 DNAH11

4.67e-041943534a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCellPCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 PIK3C2G DSP

4.67e-04194353c011cd59bb4ca4134331cba0f5d73bdbd7011d64
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP2A2 SLC7A14 USP9X

4.67e-0419435392b39a935e8c577eb1123d706d168fa13cf3344c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CTNNAL1 PIK3C2G SLC7A14

4.74e-04195353a38d9dc6192aea673d96fda6b25e81223fda3abf
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARFGEF3 HNF4A DSP

4.81e-0419635397324c9e93f833e1f218e81fb53066d44c6892df
ToppCellPCW_10-12-Epithelial|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 PIK3C2G DSP

4.81e-041963539bfb31ff3e4f2c0a9405c418c86bfec5dbca23e2
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MARCHF11 DSP SLC7A14

4.81e-041963534bdc304c0c9d8bebe1a6a8a27e44acd1e8113725
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HNF4A HNF4G DSP

4.81e-041963534deaadb9796b907b7480fb7af5ed76ebad240850
ToppCellCOVID-19-Heart-Mito_CM|COVID-19 / Disease (COVID-19 only), tissue and cell type

DSP ATP2A2 UNC45B

4.88e-0419735344e49943d62bfe622b40ad0460093d31540544df
ToppCell(08)_Brush+PNEC-(0)_Reference|(08)_Brush+PNEC / shred by cell type by condition

ACER3 ESRRA DNAH11

4.88e-04197353d500bfed2a76f7300f2f17b60962c18a40efd084
ToppCellCOVID-19-Epithelial|COVID-19 / Condition, Lineage and Cell class

ARFGEF3 DSP DNAH11

4.88e-0419735318fd7344628a87d5c7ef5efb66e260a4136245bf
ToppCelldistal-Hematologic-Platelet/Megakaryocyte|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GJB7 HNF4G DNAH11

4.88e-04197353e28b1b154d9588dce07c123b36f7f01fa90a5fc1
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HNF4A HNF4G DSP

4.88e-04197353f097e729f515e7945b9482e9f9dbc9536b90f0bb
ToppCellproximal-Epithelial-Neuroendocrine|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KCNK12 MARCHF11 HNF4A

4.95e-041983535dea6078488d584513c0bdbf5bba54877310b54a
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HNF4A DSP DGAT1

4.95e-041983538fbc461315986e357a0961a261ed10880637d6ad
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-mature_enterocytic|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HNF4A HNF4G DGAT1

4.95e-041983538fac96132663f54566136ef54b53684d31dfde32
ToppCellPCW_13-14-Epithelial|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 PIK3C2G DSP

4.95e-0419835348eb6f69a464a34ab32e8d425a22b9d45ec20428
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ITGA1 UNC45B DNAH11

4.95e-0419835322e766df1276c5b14aa0d83f434f47140ebb98ea
ToppCellSepsis-Bac-SEP-Lymphocyte-B-Plasmablast|Bac-SEP / Disease, condition lineage and cell class

KCNK12 CTNNAL1 IGKV4-1

4.95e-04198353614055c11d1dd2f3f2b8783ec35a8f4570cad161
DrugPtdIns(3,4)P

HNF4A HNF4G PIK3C2G PIK3CA

9.51e-0687354CID000643960
Diseasematurity-onset diabetes of the young type 1 (implicated_via_orthology)

HNF4A HNF4G

1.29e-062342DOID:0111099 (implicated_via_orthology)
DiseaseFanconi syndrome (implicated_via_orthology)

HNF4A HNF4G

7.72e-064342DOID:1062 (implicated_via_orthology)
Diseasematurity-onset diabetes of the young (implicated_via_orthology)

HNF4A HNF4G

5.77e-0510342DOID:0050524 (implicated_via_orthology)
DiseaseBronchiectasis

CCDC40 DNAH11

2.93e-0422342C0006267
DiseaseHereditary non-polyposis colorectal cancer syndrome

PIK3CA PALB2

4.44e-0427342C1112155
DiseaseMalignant tumor of breast

PIK3CA PALB2

4.44e-0427342cv:C0006142
DiseaseBreast neoplasm

PIK3CA PALB2

4.44e-0427342cv:C1458155
DiseaseFamilial cancer of breast

PIK3CA PALB2

4.44e-0427342cv:C0346153
DiseaseHereditary Nonpolyposis Colorectal Cancer

PIK3CA PALB2

5.13e-0429342C1333990
DiseaseVentricular Dysfunction, Left

ATP2A2 PIK3CA

5.49e-0430342C0242698
DiseaseBreast Cancer, Familial

PIK3CA PALB2

5.49e-0430342C0346153
DiseasePrimary ciliary dyskinesia

CCDC40 DNAH11

7.92e-0436342cv:C0008780
DiseaseNeoplasm of uncertain or unknown behavior of breast

PIK3CA PALB2

1.03e-0341342C0496956
DiseaseBreast adenocarcinoma

PIK3CA PALB2

1.03e-0341342C0858252

Protein segments in the cluster

PeptideGeneStartEntry
IAEFWNTVSNLIMII

ACER3

31

Q9NUN7
LASQINDLRQTVIWM

ERVK-18

411

O42043
MRQEVLEQIQVLNIW

BRD8

1196

Q9H0E9
QWRVTMLIIVLVNAF

ATP13A3

1141

Q9H7F0
TWLLQLEQTMQETVR

DNAH11

1701

Q96DT5
LQVGLIQQWMVPTIQ

DGAT1

291

O75907
LVLQLIQVMDNIWLQ

PIK3C2G

931

O75747
EELNIIIQNVMTWVV

FSIP2

506

Q5CZC0
LPTLQSITWQMIEQI

HNF4A

341

P41235
SITWQMIEQIQFIKL

HNF4A

346

P41235
MVSQVLQLLRQGVWA

PCNX2

1

A6NKB5
NVISILIKQVLNWML

KCNK12

296

Q9HB15
EWMAQILQILTVQAQ

GCN1

1001

Q92616
WNGTVVMQKASQIII

ITGA1

401

P56199
SVTRMLWEQIKQIIQ

DSTYK

536

Q6XUX3
LLPTLQSITWQMIEQ

HNF4G

291

Q14541
MLTLQIIRIMENIWQ

PIK3CA

811

P42336
LLGTTIMNNIVIWNL

PALB2

1026

Q86YC2
IMNNIVIWNLKTGQL

PALB2

1031

Q86YC2
FQITPLNVTQWLMVL

ATP2A2

956

P16615
TQARMELQQLISVWI

CTNNAL1

351

Q9UBT7
LQIENMVLSPWTLIV

GNPAT

376

O15228
AQIQAWTNMVLTVLN

ARFGEF3

2111

Q5TH69
WTNMVLTVLNQIQIL

ARFGEF3

2116

Q5TH69
QLQNIIQATSREIMW

DSP

271

P15924
VQAQVTWLRLQQEMV

CCDC40

771

Q4G0X9
QWQSISITLVEKVQM

MARCHF11

231

A6NNE9
MVLQTQVFISLLLWI

IGKV4-1

1

P06312
ISQVRLWALQLIMVS

GJB7

71

Q6PEY0
LQSVWMEVLVLGVAQ

ESRRA

261

P11474
WKIQLTQMSLQLLCV

FOCAD

261

Q5VW36
MAEWIQQNNILSIVL

USP9X

386

Q93008
LSWMQSQQQIKVLII

SHOC1

731

Q5VXU9
WLVTVLNITNLIQMV

ASCC3

1936

Q8N3C0
LNITNLIQMVIQGRW

ASCC3

1941

Q8N3C0
VLNVLNLAVWVFIMI

SLC7A14

216

Q8TBB6
KMTQVTTQWLEILQR

UNC45B

841

Q8IWX7
MQQVLNIISLLWKLS

TEX10

356

Q9NXF1
RMAEWIQQNNILSIV

USP9Y

386

O00507
AQTVILILTGIWQMR

TMED4

201

Q7Z7H5