Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

RNF152 TRIM25 RBCK1 PELI3 TRIM60 CHFR

3.32e-04473406GO:0004842
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

RNF152 TRIM25 RBCK1 PELI3 TRIM60 CHFR

5.05e-04512406GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

RNF152 TRIM25 RBCK1 PELI3 TRIM60 CHFR

6.18e-04532406GO:0016755
GeneOntologyMolecularFunctionacyltransferase activity

ACSM5 RNF152 TRIM25 RBCK1 PELI3 TRIM60 CHFR

7.86e-04775407GO:0016746
GeneOntologyMolecularFunctionubiquitin protein ligase activity

RNF152 TRIM25 PELI3 TRIM60 CHFR

8.41e-04372405GO:0061630
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

RNF152 TRIM25 PELI3 TRIM60 CHFR

1.14e-03398405GO:0061659
GeneOntologyBiologicalProcesspositive regulation of hemostasis

EMILIN2 PLAU VWF LPA

2.66e-0731374GO:1900048
GeneOntologyBiologicalProcesspositive regulation of blood coagulation

EMILIN2 PLAU VWF LPA

2.66e-0731374GO:0030194
GeneOntologyBiologicalProcesspositive regulation of coagulation

EMILIN2 PLAU VWF LPA

3.91e-0734374GO:0050820
GeneOntologyBiologicalProcesspositive regulation of wound healing

EMILIN2 PLAU VWF LPA

8.73e-0673374GO:0090303
GeneOntologyBiologicalProcessregulation of blood coagulation

EMILIN2 PLAU VWF LPA

2.09e-0591374GO:0030193
GeneOntologyBiologicalProcesspositive regulation of response to wounding

EMILIN2 PLAU VWF LPA

2.28e-0593374GO:1903036
GeneOntologyBiologicalProcessregulation of hemostasis

EMILIN2 PLAU VWF LPA

2.28e-0593374GO:1900046
GeneOntologyBiologicalProcessregulation of coagulation

EMILIN2 PLAU VWF LPA

2.59e-0596374GO:0050818
GeneOntologyBiologicalProcessprotein polyubiquitination

RNF152 TRIM25 RBCK1 PELI3 CHFR

1.57e-04289375GO:0000209
GeneOntologyBiologicalProcessregulation of wound healing

EMILIN2 PLAU VWF LPA

2.17e-04166374GO:0061041
GeneOntologyBiologicalProcessnegative regulation of fibrinolysis

PLAU LPA

2.81e-0414372GO:0051918
GeneOntologyBiologicalProcessregulation of fibrinolysis

PLAU LPA

5.25e-0419372GO:0051917
GeneOntologyBiologicalProcessregulation of response to wounding

EMILIN2 PLAU VWF LPA

5.99e-04217374GO:1903034
Domain-

PIKFYVE KDM7A RNF152 TRIM25 RBCK1 TRIM60 CHFR

3.50e-054493973.30.40.10
DomainZnf_RING/FYVE/PHD

PIKFYVE KDM7A RNF152 TRIM25 RBCK1 TRIM60 CHFR

4.03e-05459397IPR013083
Domainzf-C3HC4

RNF152 TRIM25 RBCK1 TRIM60 CHFR

9.60e-05223395PF00097
DomainZF_RING_1

RNF152 TRIM25 RBCK1 TRIM60 CHFR

3.31e-04291395PS00518
DomainZnf_RING_CS

TRIM25 RBCK1 TRIM60 CHFR

3.62e-04163394IPR017907
DomainZF_RING_2

RNF152 TRIM25 RBCK1 TRIM60 CHFR

3.69e-04298395PS50089
DomainRING

RNF152 TRIM25 RBCK1 TRIM60 CHFR

4.10e-04305395SM00184
DomainZnf_C3HC4_RING-type

RNF152 TRIM25 RBCK1 TRIM60

4.44e-04172394IPR018957
DomainZnf_RING

RNF152 TRIM25 RBCK1 TRIM60 CHFR

5.56e-04326395IPR001841
DomainKringle

PLAU LPA

5.66e-0417392IPR000001
DomainKringle

PLAU LPA

5.66e-0417392PF00051
DomainKRINGLE_1

PLAU LPA

5.66e-0417392PS00021
DomainKringle_CS

PLAU LPA

5.66e-0417392IPR018056
DomainKR

PLAU LPA

5.66e-0417392SM00130
DomainKRINGLE_2

PLAU LPA

5.66e-0417392PS50070
DomainZnf_B-box

TRIM25 RBCK1 TRIM60

6.42e-0481393IPR000315
DomainKringle-like

PLAU LPA

2.03e-0332392IPR013806
DomainZnf-RING_LisH

TRIM25 RBCK1

2.29e-0334392IPR027370
Domainzf-RING_UBOX

TRIM25 RBCK1

2.29e-0334392PF13445
DomainPRY

TRIM25 TRIM60

3.47e-0342392PF13765
DomainPRY

TRIM25 TRIM60

4.51e-0348392SM00589
DomainPRY

TRIM25 TRIM60

4.51e-0348392IPR006574
DomainButyrophylin

TRIM25 TRIM60

9.38e-0370392IPR003879
Domain-

TRIM25 TRIM60

9.64e-03713924.10.45.10
DomainConA-like_dom

ADGRD2 TRIM25 TRIM60

1.07e-02219393IPR013320
DomainZF_BBOX

RBCK1 TRIM60

1.21e-0280392PS50119
PathwayWP_BLOOD_CLOTTING_CASCADE

PLAU VWF LPA

9.63e-0623263MM15936
PathwayBIOCARTA_FIBRINOLYSIS_PATHWAY

PLAU LPA

2.13e-0412262MM1398
PathwayBIOCARTA_PLATELETAPP_PATHWAY

PLAU LPA

2.94e-0414262MM1458
PathwayREACTOME_DISSOLUTION_OF_FIBRIN_CLOT

PLAU LPA

3.38e-0415262MM15450
Pubmed

Lactational competence and involution of the mouse mammary gland require plasminogen.

PLAU LPA

3.87e-06340211003846
Pubmed

Plasminogen directs the pleiotropic effects of uPA in liver injury and repair.

PLAU LPA

3.87e-06340212431907
Pubmed

The plasminogen activator/plasmin system is essential for development of the joint inflammatory phase of collagen type II-induced arthritis.

PLAU LPA

3.87e-06340215743790
Pubmed

Plasmin activity is required for myogenesis in vitro and skeletal muscle regeneration in vivo.

PLAU LPA

3.87e-06340211929773
Pubmed

Involvement of the proto-oncogene c-ets 1 and the urokinase plasminogen activator during mouse implantation and placentation.

PLAU VWF

3.87e-0634028179996
Pubmed

Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation.

PLAU LPA

7.73e-06440228336948
Pubmed

Beneficial and detrimental effects of plasmin(ogen) during infection and sepsis in mice.

PLAU LPA

7.73e-06440221931850
Pubmed

Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation.

PLAU LPA

7.73e-06440219210287
Pubmed

Plasmin is essential in preventing periodontitis in mice.

PLAU LPA

7.73e-06440221704601
Pubmed

The role of plasminogen in angiogenesis in vivo.

PLAU LPA

7.73e-06440212911578
Pubmed

Mice lacking tPA, uPA, or plasminogen genes showed delayed functional recovery after sciatic nerve crush.

PLAU LPA

7.73e-06440211404420
Pubmed

Mechanisms of cardiac fibrosis induced by urokinase plasminogen activator.

PLAU LPA

7.73e-06440216554301
Pubmed

Phenotypic overlap between MMP-13 and the plasminogen activation system during wound healing in mice.

PLAU LPA

7.73e-06440221326869
Pubmed

Plasminogen activator induction facilitates recovery of respiratory function following spinal cord injury.

PLAU LPA

7.73e-06440218042398
Pubmed

Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.

PLAU LPA

7.73e-06440216763560
Pubmed

Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair.

PLAU LPA

7.73e-06440219286661
Pubmed

Plasminogen mediates the pathological effects of urokinase-type plasminogen activator overexpression.

PLAU LPA

7.73e-06440215161662
Pubmed

Early embryonic expression of murine coagulation system components.

PLAU VWF LPA

8.23e-063440311154109
Pubmed

The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent.

PLAU LPA

1.29e-05540211818362
Pubmed

Deficiency of urokinase-type plasminogen activator-mediated plasmin generation impairs vascular remodeling during hypoxia-induced pulmonary hypertension in mice.

PLAU LPA

1.29e-05540211306532
Pubmed

Plasminogen mediates the atherogenic effects of macrophage-expressed urokinase and accelerates atherosclerosis in apoE-knockout mice.

PLAU LPA

1.29e-05540218957535
Pubmed

Mice without uPA, tPA, or plasminogen genes are resistant to experimental choroidal neovascularization.

PLAU LPA

1.29e-05540212657615
Pubmed

The development of bleomycin-induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system.

PLAU LPA

1.29e-05540210880388
Pubmed

Urokinase-type plasminogen activator (uPA) regulates the expression and function of growth-associated protein 43 (GAP-43) in the synapse.

PLAU LPA

1.29e-05540231819012
Pubmed

The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection.

PLAU LPA

1.29e-05540212875972
Pubmed

Soluble M6P/IGF2R released by TACE controls angiogenesis via blocking plasminogen activation.

PLAU LPA

1.29e-05540221273553
Pubmed

Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice.

PLAU LPA

1.93e-05640210318667
Pubmed

Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction.

TRIM25 RBCK1

1.93e-05640221292167
Pubmed

Synergy between a plasminogen cascade and MMP-9 in autoimmune disease.

PLAU LPA

1.93e-05640215841177
Pubmed

The Tissue Fibrinolytic System Contributes to the Induction of Macrophage Function and CCL3 during Bone Repair in Mice.

PLAU LPA

3.60e-05840225893677
Pubmed

The Penta-EF-Hand ALG-2 Protein Interacts with the Cytosolic Domain of the SOCE Regulator SARAF and Interferes with Ubiquitination.

FNDC3A SHISA4

3.60e-05840232878247
Pubmed

Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesis.

PLAU LPA

3.60e-0584029438420
Pubmed

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

EMILIN2 VWF ECM1 LPA

4.10e-0516740422159717
Pubmed

Hemostatic gene polymorphisms in young Sardinian with non-fatal acute myocardial infarction.

VWF LPA

5.77e-051040220036902
Pubmed

A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo.

PLAU LPA

7.05e-051140226647393
Pubmed

Direct activation of protein kinases by unanchored polyubiquitin chains.

TRIM25 RBCK1

9.98e-051340219675569
Pubmed

A mouse knockout library for secreted and transmembrane proteins.

CLDN14 LYPD6 GPC6 SHISA4 SUMF1

1.78e-0446040520562862
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

TRIM25 RBCK1 CHFR

1.81e-049540329643511
Pubmed

Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.

TRIM25 RBCK1 CHFR

2.44e-0410540322493164
Pubmed

Tissue-Specific Gain of RTK Signalling Uncovers Selective Cell Vulnerability during Embryogenesis.

PLAU GPC6

3.80e-042540226393505
Pubmed

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.

TRIM25 RBCK1 CHFR

6.78e-0414940319549727
Pubmed

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

EMILIN2 VWF ECM1

7.32e-0415340325037231
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

VWF ECM1 LPA

1.08e-0317540328071719
Pubmed

Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.

PLAU VWF

1.13e-034340220565774
GeneFamilyRing finger proteins

RNF152 TRIM25 RBCK1 TRIM60 CHFR

6.91e-0527529558
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM25 TRIM60

1.01e-029529259
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-regulatory_T_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ZC2HC1A ZC3H3 ZNF783 ZNF646

8.88e-061464047748277cf2f12e2930d4f5a22247ab9bc266a954
ToppCell356C-Endothelial_cells-Endothelial-E-|356C / Donor, Lineage, Cell class and subclass (all cells)

CLDN14 VWF FAM124B GDF9

2.30e-051864042e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell356C-Endothelial_cells-Endothelial-E|356C / Donor, Lineage, Cell class and subclass (all cells)

CLDN14 VWF FAM124B GDF9

2.30e-05186404c3449e54454009973818fc1101933c6f0168258c
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STMN2 VWF GPC6 ECM1

2.35e-05187404ddfc2d1d9fcc3d8e4d3d015576bb17eebf44ada9
ToppCellrenal_cortex_nuclei-Adult_normal_reference|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

CCND3 FNDC3A RNF152 SUMF1

2.45e-05189404a48df46274d51e84ffb40264646de7346104efb9
DiseaseThromboembolism

PLAU LPA

1.00e-0412372C0040038
DiseaseDeep Vein Thrombosis

PLAU LPA

3.16e-0421372C0149871
DiseaseVenous Thrombosis

PLAU LPA

3.16e-0421372C0042487
DiseaseCoronary heart disease

PLAU LPA

4.15e-0424372C0010068
Diseaserenal cell carcinoma (is_marker_for)

CCND3 PLAU VWF

5.56e-04128373DOID:4450 (is_marker_for)
Diseaselumbar disc degeneration

GPC6 SUMF1

5.67e-0428372EFO_0004994
DiseaseCardiovascular Diseases

VWF LPA

9.38e-0436372C0007222
Diseaseatherosclerosis (is_marker_for)

PLAU LPA

9.91e-0437372DOID:1936 (is_marker_for)
Diseaseend stage renal disease (is_implicated_in)

PLAU VWF

1.22e-0341372DOID:783 (is_implicated_in)
Diseaseend stage renal disease (is_marker_for)

PLAU VWF

1.53e-0346372DOID:783 (is_marker_for)
DiseaseThrombus

PLAU VWF

1.53e-0346372C0087086
DiseaseThrombosis

PLAU VWF

1.73e-0349372C0040053
Diseasemonokine induced by gamma interferon measurement

FAM124B LPA

1.95e-0352372EFO_0008236
DiseaseAcute Cerebrovascular Accidents

PLAU LPA

2.10e-0354372C0751956

Protein segments in the cluster

PeptideGeneStartEntry
ERYVPRASYFQCVQR

CCND3

36

P30281
VRIRPTRPFCFFNCY

ACSM5

421

Q6NUN0
PPVYCVCRQPYDVNR

KDM7A

36

Q6ZMT4
CCRARPEAYQVPASY

RBCK1

216

Q9BYM8
IFLERYCFRPSYQCP

PIKFYVE

1256

Q9Y2I7
ISQPYVVCRQCPEYR

CHFR

421

Q96EP1
CYPTQDTRGRLCPYF

FAM124B

96

Q9H5Z6
YCRGLPTVRPCNNYC

GPC6

256

Q9Y625
LCLSCQDEAPYRPYQ

CLDN14

181

O95500
DRLNPGCFYRLRVYC

FNDC3A

626

Q9Y2H6
CRSQEYRIGRCPNTY

DEFB104A

41

Q8WTQ1
CRNPDAVAAPYCYTR

LPA

191

P08519
CRNPDAVAAPYCYTR

LPA

761

P08519
PDIYCPRETRYCYTQ

LYPD6

66

Q86Y78
YRPACYRPCYSILRR

KRTAP16-1

421

A8MUX0
RYNPRYCKGDCPRAV

GDF9

376

O60383
TRDECFARRAPYPNY

ECM1

391

Q16610
CPSALVYRVNFRPRY

EMILIN2

81

Q9BXX0
APHYNSCCRRKYRPE

SCNM1

121

Q9BWG6
YQQVCARYRALCVPP

PTCHD3

251

Q3KNS1
YCRNPDNRRRPWCYV

PLAU

121

P00749
ECQICFNYYSPRRRP

RNF152

11

Q8N8N0
RYACRILCDRRPPYT

PELI3

186

Q8N2H9
YCYRVNRRLFPVPVD

MIIP

241

Q5JXC2
CCYLYRRRQQLQSPF

SHISA4

111

Q96DD7
VPCCQQLSRFNRYYS

URB1

846

O60287
CYRYRCAARSQNTPD

SUMF1

341

Q8NBK3
QPFLCCYRTEPYRRL

ADGRD2

351

Q7Z7M1
YNRFGRCNRGERCPY

ZC3H3

676

Q8IXZ2
PLPYLRNCRYDVCSC

VWF

601

P04275
RAERYNIEPSLYCPF

MIPEP

366

Q99797
SPYLCPQCRAVYQAR

TRIM25

46

Q14258
RPYRCQQCGRGYRHP

ZNF646

46

O15015
CPVCSRCYPNLAAYR

ZNF646

1081

O15015
ICYDPRRFYVCPAVL

TRIM60

326

Q495X7
DPDYIQCPYCQRRFN

ZC2HC1A

116

Q96GY0
QPARYTCPRCNAPYC

ZNHIT2

16

Q9UHR6
ICSCFYPEPRNINIY

STMN2

21

Q93045
PRNYPTAKYTCRLCD

TUT7

236

Q5VYS8
QRPYPCPECDKTFRY

ZNF425

271

Q6IV72
ERPYQCPQCGRTFNR

ZNF783

491

Q6ZMS7
RRPGCYAYRQNPEAI

MYORG

16

Q6NSJ0