Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	GLUD1 GLUD2	1.92e-05	2	88	2	GO:0016639
GeneOntologyMolecularFunction	glutamate dehydrogenase [NAD(P)+] activity	GLUD1 GLUD2	1.92e-05	2	88	2	GO:0004353
GeneOntologyMolecularFunction	glutamate dehydrogenase (NAD+) activity	GLUD1 GLUD2	1.92e-05	2	88	2	GO:0004352
GeneOntologyMolecularFunction	glutamate dehydrogenase (NADP+) activity	GLUD1 GLUD2	1.92e-05	2	88	2	GO:0004354
GeneOntologyMolecularFunction	amino acid sensor activity	SAR1B SAR1A	1.92e-05	2	88	2	GO:0140785
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR2 ITPR3	5.74e-05	3	88	2	GO:0005220
GeneOntologyMolecularFunction	AMP binding	ACSS1 PFKM ACSS2	1.04e-04	21	88	3	GO:0016208
GeneOntologyMolecularFunction	propionate-CoA ligase activity	ACSS1 ACSS2	1.15e-04	4	88	2	GO:0050218
GeneOntologyMolecularFunction	short-chain fatty acid-CoA ligase activity	ACSS1 ACSS2	1.15e-04	4	88	2	GO:0031955
GeneOntologyMolecularFunction	acetate-CoA ligase activity	ACSS1 ACSS2	1.15e-04	4	88	2	GO:0003987
GeneOntologyMolecularFunction	L-leucine binding	GLUD1 GLUD2	3.97e-04	7	88	2	GO:0070728
GeneOntologyBiologicalProcess	propionate biosynthetic process	ACSS1 ACSS2	1.76e-05	2	87	2	GO:0019542
GeneOntologyBiologicalProcess	acetate biosynthetic process	ACSS1 ACSS2	1.76e-05	2	87	2	GO:0019413
GeneOntologyBiologicalProcess	acetyl-CoA biosynthetic process from acetate	ACSS1 ACSS2	1.76e-05	2	87	2	GO:0019427
GeneOntologyBiologicalProcess	phospholipid metabolic process	PNPLA6 PLPPR4 FIG4 PGAP1 PHB2 LPGAT1 SOCS1 PLPPR3 PRDX6	5.79e-05	410	87	9	GO:0006644
GeneOntologyBiologicalProcess	short-chain fatty acid biosynthetic process	ACSS1 ACSS2	1.05e-04	4	87	2	GO:0051790
GeneOntologyBiologicalProcess	acetate metabolic process	ACSS1 ACSS2	1.05e-04	4	87	2	GO:0006083
GeneOntologyBiologicalProcess	propionate metabolic process	ACSS1 ACSS2	1.74e-04	5	87	2	GO:0019541
GeneOntologyBiologicalProcess	glutamate biosynthetic process	GLUD1 GLUD2	1.74e-04	5	87	2	GO:0006537
GeneOntologyBiologicalProcess	regulation of COPII vesicle coating	SAR1B SAR1A	1.74e-04	5	87	2	GO:0003400
GeneOntologyBiologicalProcess	response to aluminum ion	GLUD1 GLUD2	2.61e-04	6	87	2	GO:0010044
GeneOntologyBiologicalProcess	organophosphate metabolic process	PNPLA6 PLPPR4 FIG4 ACSS1 PGAP1 MDH1B PHB2 LPGAT1 SOCS1 PLPPR3 PFKM ACSS2 SLC25A19 PRDX6	2.87e-04	1142	87	14	GO:0019637
GeneOntologyCellularComponent	mitochondrial matrix	CBR4 MTG2 MRPL37 ACSS1 GLUD1 PYROXD2 GLUD2 COX15 SARDH ACSS2 TST	9.73e-06	523	86	11	GO:0005759
GeneOntologyCellularComponent	mitochondrial inner membrane	COX20 MTG2 MRPL37 GLUD1 GLUD2 PHB2 COX15 TST SLC25A19 TIMMDC1	1.60e-04	593	86	10	GO:0005743
GeneOntologyCellularComponent	organelle inner membrane	COX20 MTG2 MRPL37 GLUD1 GLUD2 PHB2 COX15 TST SLC25A19 TIMMDC1	3.41e-04	652	86	10	GO:0019866
GeneOntologyCellularComponent	platelet dense tubular network membrane	ITPR2 ITPR3	5.91e-04	9	86	2	GO:0031095
GeneOntologyCellularComponent	mitochondrial membrane	COX20 RNF5 MTG2 MRPL37 GLUD1 GLUD2 PHB2 COX15 TST SLC25A19 TIMMDC1	8.31e-04	866	86	11	GO:0031966
GeneOntologyCellularComponent	platelet dense tubular network	ITPR2 ITPR3	8.98e-04	11	86	2	GO:0031094
GeneOntologyCellularComponent	mitochondrial envelope	COX20 RNF5 MTG2 MRPL37 GLUD1 GLUD2 PHB2 COX15 TST SLC25A19 TIMMDC1	1.26e-03	912	86	11	GO:0005740
Domain	MIR	SDF2L1 ITPR2 ITPR3	1.14e-05	10	87	3	PS50919
Domain	MIR	SDF2L1 ITPR2 ITPR3	1.14e-05	10	87	3	PF02815
Domain	MIR	SDF2L1 ITPR2 ITPR3	1.14e-05	10	87	3	SM00472
Domain	MIR_motif	SDF2L1 ITPR2 ITPR3	1.14e-05	10	87	3	IPR016093
Domain	ELFV_dehydrog_N	GLUD1 GLUD2	2.14e-05	2	87	2	PF02812
Domain	Glu/Leu/Phe/Val_DH_C	GLUD1 GLUD2	2.14e-05	2	87	2	IPR006096
Domain	Glu/Leu/Phe/Val_DH_dimer_dom	GLUD1 GLUD2	2.14e-05	2	87	2	IPR006097
Domain	Glu/Leu/Phe/Val_DH	GLUD1 GLUD2	2.14e-05	2	87	2	IPR006095
Domain	ELFV_dehydrog	GLUD1 GLUD2	2.14e-05	2	87	2	PF00208
Domain	ELFV_dehydrog	GLUD1 GLUD2	2.14e-05	2	87	2	SM00839
Domain	Glu/Leu/Phe/Val_DH_AS	GLUD1 GLUD2	2.14e-05	2	87	2	IPR033524
Domain	Small_GTPase_SAR1	SAR1B SAR1A	2.14e-05	2	87	2	IPR006687
Domain	NAD_bind_Glu_DH	GLUD1 GLUD2	2.14e-05	2	87	2	IPR033922
Domain	Ac_CoA_lig	ACSS1 ACSS2	2.14e-05	2	87	2	IPR011904
Domain	SAR1	SAR1B SAR1A	2.14e-05	2	87	2	PS51422
Domain	GLFV_DEHYDROGENASE	GLUD1 GLUD2	2.14e-05	2	87	2	PS00074
Domain	InsP3_rcpt-bd	ITPR2 ITPR3	6.42e-05	3	87	2	IPR000493
Domain	ACAS_N	ACSS1 ACSS2	1.28e-04	4	87	2	PF16177
Domain	ACAS_N	ACSS1 ACSS2	1.28e-04	4	87	2	IPR032387
Domain	Cadherin	PCDHGB3 PCDHGA10 PCDHGA2 CDHR1 FREM1	2.26e-04	118	87	5	IPR002126
Domain	RIH_assoc	ITPR2 ITPR3	3.18e-04	6	87	2	PF08454
Domain	RIH_assoc-dom	ITPR2 ITPR3	3.18e-04	6	87	2	IPR013662
Domain	RIH_dom	ITPR2 ITPR3	3.18e-04	6	87	2	IPR000699
Domain	Ins145_P3_rcpt	ITPR2 ITPR3	3.18e-04	6	87	2	IPR014821
Domain	Ryanodine_recept-rel	ITPR2 ITPR3	3.18e-04	6	87	2	IPR015925
Domain	-	ITPR2 ITPR3	3.18e-04	6	87	2	1.25.10.30
Domain	RYDR_ITPR	ITPR2 ITPR3	3.18e-04	6	87	2	PF01365
Domain	Ins145_P3_rec	ITPR2 ITPR3	3.18e-04	6	87	2	PF08709
Domain	SIX1_SD	SIX3 SIX6	4.44e-04	7	87	2	PF16878
Domain	SIX1_SD	SIX3 SIX6	4.44e-04	7	87	2	IPR031701
Domain	Cadherin_tail	PCDHGB3 PCDHGA10 PCDHGA2	6.76e-04	37	87	3	PF15974
Domain	Cadherin_CBD	PCDHGB3 PCDHGA10 PCDHGA2	6.76e-04	37	87	3	IPR031904
Domain	Amino_oxidase	PYROXD2 KDM1B	9.42e-04	10	87	2	IPR002937
Domain	Amino_oxidase	PYROXD2 KDM1B	9.42e-04	10	87	2	PF01593
Domain	Cadherin_C	PCDHGB3 PCDHGA10 PCDHGA2	9.83e-04	42	87	3	IPR032455
Domain	Cadherin_C_2	PCDHGB3 PCDHGA10 PCDHGA2	9.83e-04	42	87	3	PF16492
Domain	Cadherin_CS	PCDHGB3 PCDHGA10 PCDHGA2 CDHR1	1.68e-03	109	87	4	IPR020894
Domain	CADHERIN_1	PCDHGB3 PCDHGA10 PCDHGA2 CDHR1	1.92e-03	113	87	4	PS00232
Domain	Cadherin	PCDHGB3 PCDHGA10 PCDHGA2 CDHR1	1.92e-03	113	87	4	PF00028
Domain	CADHERIN_2	PCDHGB3 PCDHGA10 PCDHGA2 CDHR1	1.99e-03	114	87	4	PS50268
Domain	-	PCDHGB3 PCDHGA10 PCDHGA2 CDHR1	1.99e-03	114	87	4	2.60.40.60
Domain	CA	PCDHGB3 PCDHGA10 PCDHGA2 CDHR1	2.05e-03	115	87	4	SM00112
Domain	Cadherin-like	PCDHGB3 PCDHGA10 PCDHGA2 CDHR1	2.12e-03	116	87	4	IPR015919
Domain	-	PYROXD2 KDM1B SARDH	2.26e-03	56	87	3	3.50.50.60
Domain	FAD/NAD-binding_dom	PYROXD2 KDM1B SARDH	2.38e-03	57	87	3	IPR023753
Domain	Chemokine_rcpt	CCR1 CCR3	2.47e-03	16	87	2	IPR000355
Domain	AMP-bd_C	ACSS1 ACSS2	2.79e-03	17	87	2	IPR025110
Domain	AMP-binding_C	ACSS1 ACSS2	2.79e-03	17	87	2	PF13193
Domain	-	PLPPR4 PLPPR3	3.13e-03	18	87	2	1.20.144.10
Domain	acidPPc	PLPPR4 PLPPR3	3.13e-03	18	87	2	SM00014
Domain	Cadherin_2	PCDHGB3 PCDHGA10 PCDHGA2	3.46e-03	65	87	3	PF08266
Domain	Cadherin_N	PCDHGB3 PCDHGA10 PCDHGA2	3.46e-03	65	87	3	IPR013164
Domain	P_Acid_Pase_2/haloperoxidase	PLPPR4 PLPPR3	3.86e-03	20	87	2	IPR000326
Domain	PAP2	PLPPR4 PLPPR3	3.86e-03	20	87	2	PF01569
Domain	AMP-binding_CS	ACSS1 ACSS2	6.48e-03	26	87	2	IPR020845
Domain	WD40_repeat_CS	RRP9 WDFY3 BRWD1 WDR72	7.25e-03	164	87	4	IPR019775
Domain	AMP_BINDING	ACSS1 ACSS2	7.49e-03	28	87	2	PS00455
Domain	Small_GTP-bd_dom	MTG2 SAR1B RND2 SAR1A	7.72e-03	167	87	4	IPR005225
Domain	-	CBR4 GLUD1 GLUD2 MDH1B	8.04e-03	169	87	4	3.40.50.720
Domain	AMP-binding	ACSS1 ACSS2	8.57e-03	30	87	2	PF00501
Pathway	REACTOME_TRANSCRIPTIONAL_ACTIVATION_OF_MITOCHONDRIAL_BIOGENESIS	GLUD1 GLUD2 ACSS2	1.72e-05	11	68	3	MM14866
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY	ITPR2 ITPR3	2.27e-04	5	68	2	M49000
Pathway	BIOCARTA_WNT_LRP6_PATHWAY	KREMEN2 WNT8B	3.40e-04	6	68	2	MM1588
Pathway	BIOCARTA_WNT_LRP6_PATHWAY	KREMEN2 WNT8B	3.40e-04	6	68	2	M22083
Pathway	KEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY	ITPR2 ITPR3	3.40e-04	6	68	2	M47960
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	BMP2K RRP9 MTG2 MRPL37 ACSS1 SAR1B GLUD1 SUPT16H PHB2 COX15 MSI1 PFKM TIMMDC1 NEURL4 RRP1 MSI2 ITPR2 ITPR3	3.81e-08	1496	89	18	32877691
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	LRIG2 PNPLA6 SLC4A1AP RRP9 MRPL37 GLUD1 SUPT16H RPS13 PHB2 SDF2L1 COX15 PFKM TIMMDC1 NEURL4 RRP1 ITPR2 ITPR3	1.99e-07	1487	89	17	33957083
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	CBR4 COX20 MTG2 MRPL37 ACSS1 GLUD1 GLUD2 PHB2 COX15 SARDH TST SLC25A19 TIMMDC1 PRDX6	4.31e-07	1047	89	14	18614015
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	CBR4 COX20 MTG2 MRPL37 ACSS1 GLUD1 PHB2 COX15 SARDH TST SLC25A19 TIMMDC1 PRDX6	6.76e-07	926	89	13	20877624
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	CBR4 COX20 MTG2 MRPL37 ACSS1 GLUD1 PYROXD2 GLUD2 PHB2 COX15 SARDH TST SLC25A19 TIMMDC1	1.13e-06	1136	89	14	34800366
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	KIF20A GTPBP2 SALL2 PNPLA6 HMCN2 SH3TC1 SUPT16H MSI1 WDFY3 KDM1B SLC25A19 BRWD1 WDR72	5.24e-06	1116	89	13	31753913
Pubmed	Crystal and solution structures of human oncoprotein Musashi-2 N-terminal RNA recognition motif 1.	MSI1 MSI2	6.48e-06	2	89	2	31603583
Pubmed	Focus on molecules: Wnt8b: a suppressor of early eye and retinal progenitor formation.	WNT8B SIX3	6.48e-06	2	89	2	21219900
Pubmed	Critical role of the cysteine 323 residue in the catalytic activity of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	6.48e-06	2	89	2	15750346
Pubmed	The rs13075270 and rs13092160 polymorphisms of CCR1 and CCR3 genes on oral aphthous-like lesions in PFAPA syndrome.	CCR1 CCR3	6.48e-06	2	89	2	35809272
Pubmed	Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.	ITPR2 ITPR3	6.48e-06	2	89	2	9065779
Pubmed	Molecular cloning, structure and expression analysis of a full-length mouse brain glutamate dehydrogenase cDNA.	GLUD1 GLUD2	6.48e-06	2	89	2	1711373
Pubmed	Knockdown of Musashi RNA Binding Proteins Decreases Radioresistance but Enhances Cell Motility and Invasion in Triple-Negative Breast Cancer.	MSI1 MSI2	6.48e-06	2	89	2	32245259
Pubmed	Expression of RNA-binding protein Musashi in hair follicle development and hair cycle progression.	MSI1 MSI2	6.48e-06	2	89	2	16400011
Pubmed	Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors.	GLUD1 GLUD2	6.48e-06	2	89	2	34173171
Pubmed	Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.	GLUD1 GLUD2	6.48e-06	2	89	2	28621566
Pubmed	Increased expression of chemokine receptors CCR1 and CCR3 in nasal polyps: molecular basis for recruitment of the granulocyte infiltrate.	CCR1 CCR3	6.48e-06	2	89	2	23054685
Pubmed	Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.	ITPR2 ITPR3	6.48e-06	2	89	2	17496801
Pubmed	GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior.	GLUD1 GLUD2	6.48e-06	2	89	2	32078638
Pubmed	Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate.	GLUD1 GLUD2	6.48e-06	2	89	2	20529287
Pubmed	Development of mice with brain-specific deletion of floxed glud1 (glutamate dehydrogenase 1) using cre recombinase driven by the nestin promoter.	GLUD1 GLUD2	6.48e-06	2	89	2	23595828
Pubmed	Determination of glutamate dehydrogenase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry).	GLUD1 GLUD2	6.48e-06	2	89	2	25124006
Pubmed	Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.	ITPR2 ITPR3	6.48e-06	2	89	2	24901844
Pubmed	Unexpected histone H3 tail-clipping activity of glutamate dehydrogenase.	GLUD1 GLUD2	6.48e-06	2	89	2	23673664
Pubmed	Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.	ITPR2 ITPR3	6.48e-06	2	89	2	33854148
Pubmed	Interaction between glutamate dehydrogenase (GDH) and L-leucine catabolic enzymes: intersecting metabolic pathways.	GLUD1 GLUD2	6.48e-06	2	89	2	21621574
Pubmed	Lack of evidence for direct ligand-gated ion channel activity of GluD receptors.	GLUD1 GLUD2	6.48e-06	2	89	2	39052831
Pubmed	Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice.	GLUD1 GLUD2	6.48e-06	2	89	2	24442550
Pubmed	Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.	GLUD1 GLUD2	6.48e-06	2	89	2	28911206
Pubmed	The Musashi proteins MSI1 and MSI2 are required for photoreceptor morphogenesis and vision in mice.	MSI1 MSI2	6.48e-06	2	89	2	33168629
Pubmed	The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity.	GLUD1 GLUD2	6.48e-06	2	89	2	27137930
Pubmed	GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.	GLUD1 GLUD2	6.48e-06	2	89	2	26440896
Pubmed	Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase.	GLUD1 GLUD2	6.48e-06	2	89	2	22875990
Pubmed	Msi RNA-binding proteins control reserve intestinal stem cell quiescence.	MSI1 MSI2	6.48e-06	2	89	2	27799368
Pubmed	Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.	ITPR2 ITPR3	6.48e-06	2	89	2	19528657
Pubmed	Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme.	GLUD1 GLUD2	6.48e-06	2	89	2	12742085
Pubmed	Molecular basis of human glutamate dehydrogenase regulation under changing energy demands.	GLUD1 GLUD2	6.48e-06	2	89	2	15578726
Pubmed	Important role of Ser443 in different thermal stability of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	6.48e-06	2	89	2	15044002
Pubmed	The importance of acetyl coenzyme A synthetase for 11C-acetate uptake and cell survival in hepatocellular carcinoma.	ACSS1 ACSS2	6.48e-06	2	89	2	19617323
Pubmed	Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.	ITPR2 ITPR3	6.48e-06	2	89	2	8063813
Pubmed	The RNA-binding protein Musashi is required intrinsically to maintain stem cell identity.	MSI1 MSI2	6.48e-06	2	89	2	16717192
Pubmed	Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.	ITPR2 ITPR3	6.48e-06	2	89	2	8081734
Pubmed	Induction of excitatory and inhibitory presynaptic differentiation by GluD1.	GLUD1 GLUD2	6.48e-06	2	89	2	22138648
Pubmed	Two-stage association study in Chinese Han identifies two independent associations in CCR1/CCR3 locus as candidate for Behçet's disease susceptibility.	CCR1 CCR3	6.48e-06	2	89	2	22829007
Pubmed	Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia.	GLUD1 GLUD2	6.48e-06	2	89	2	34220417
Pubmed	Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state.	MSI1 MSI2	6.48e-06	2	89	2	25380226
Pubmed	Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues.	GLUD1 GLUD2	6.48e-06	2	89	2	26241911
Pubmed	Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo.	SAR1B SAR1A	6.48e-06	2	89	2	38687799
Pubmed	Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate.	ACSS1 ACSS2	6.48e-06	2	89	2	11150295
Pubmed	Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes.	MSI1 MSI2	6.48e-06	2	89	2	22113197
Pubmed	Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth.	ACSS1 ACSS2	6.48e-06	2	89	2	27539851
Pubmed	Musashi RNA-Binding Proteins as Cancer Drivers and Novel Therapeutic Targets.	MSI1 MSI2	6.48e-06	2	89	2	28143872
Pubmed	Chemokine receptor mRNA expression at the in vitro blood-brain barrier during HIV infection.	CCR1 CCR3	6.48e-06	2	89	2	10094132
Pubmed	Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein.	MSI1 MSI2	6.48e-06	2	89	2	35840700
Pubmed	Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum.	GLUD1 GLUD2	6.48e-06	2	89	2	21446915
Pubmed	Involvement of suppressor of cytokine signaling-1 in globular adiponectin-induced granulocyte colony-stimulating factor in RAW 264 cell.	CSF3 SOCS1	6.48e-06	2	89	2	21764457
Pubmed	Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection.	GLUD1 GLUD2	6.48e-06	2	89	2	18688271
Pubmed	IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism.	ITPR2 ITPR3	6.48e-06	2	89	2	16195467
Pubmed	KSHV enhances mesenchymal stem cell homing and promotes KS-like pathogenesis.	CCR1 CCR3	6.48e-06	2	89	2	32777727
Pubmed	The complex regulation of human glud1 and glud2 glutamate dehydrogenases and its implications in nerve tissue biology.	GLUD1 GLUD2	6.48e-06	2	89	2	22658952
Pubmed	Variations in eosinophil chemokine responses: an investigation of CCR1 and CCR3 function, expression in atopy, and identification of a functional CCR1 promoter.	CCR1 CCR3	6.48e-06	2	89	2	12794150
Pubmed	GluD1 binds GABA and controls inhibitory plasticity.	GLUD1 GLUD2	6.48e-06	2	89	2	38060673
Pubmed	Dysregulated Stem Cell Markers Musashi-1 and Musashi-2 are Associated with Therapy Resistance in Inflammatory Breast Cancer.	MSI1 MSI2	6.48e-06	2	89	2	37481823
Pubmed	Silencing of mammalian Sar1 isoforms reveals COPII-independent protein sorting and transport.	SAR1B SAR1A	6.48e-06	2	89	2	23433038
Pubmed	Knockout of RNA Binding Protein MSI2 Impairs Follicle Development in the Mouse Ovary: Characterization of MSI1 and MSI2 during Folliculogenesis.	MSI1 MSI2	6.48e-06	2	89	2	26131972
Pubmed	Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice.	GLUD1 GLUD2	6.48e-06	2	89	2	24593767
Pubmed	RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation.	MSI1 MSI2	6.48e-06	2	89	2	12407178
Pubmed	The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis.	SAR1B SAR1A	6.48e-06	2	89	2	24338480
Pubmed	Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.	ITPR2 ITPR3	6.48e-06	2	89	2	15632133
Pubmed	Increases in anterograde axoplasmic transport in neurons of the hyper-glutamatergic, glutamate dehydrogenase 1 (Glud1) transgenic mouse: Effects of glutamate receptors on transport.	GLUD1 GLUD2	6.48e-06	2	89	2	38124277
Pubmed	Potentiation of neuronal activity by tonic GluD1 current in brain slices.	GLUD1 GLUD2	6.48e-06	2	89	2	37154294
Pubmed	RNA binding proteins in spermatogenesis: an in depth focus on the Musashi family.	MSI1 MSI2	6.48e-06	2	89	2	25851660
Pubmed	Assessment of MUSASHI 1 and MUSASHI 2 expression in spermatozoa and testicular tissue.	MSI1 MSI2	6.48e-06	2	89	2	34309875
Pubmed	Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.	GLUD1 GLUD2	6.48e-06	2	89	2	19015267
Pubmed	Inositol (1,4,5)-trisphosphate receptor links to filamentous actin are important for generating local Ca2+ signals in pancreatic acinar cells.	ITPR2 ITPR3	6.48e-06	2	89	2	15713744
Pubmed	Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.	GLUD1 GLUD2	6.48e-06	2	89	2	22924626
Pubmed	Interplay between the RNA binding-protein Musashi and developmental signaling pathways.	MSI1 MSI2	6.48e-06	2	89	2	31692135
Pubmed	Modulation of membrane rigidity by the human vesicle trafficking proteins Sar1A and Sar1B.	SAR1B SAR1A	6.48e-06	2	89	2	22974979
Pubmed	Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum.	GLUD1 GLUD2	6.48e-06	2	89	2	19448744
Pubmed	Comparative analysis of Six 3 and Six 6 distribution in the developing and adult mouse brain.	SIX3 SIX6	6.48e-06	2	89	2	15973738
Pubmed	The expression of granulocyte macrophage-colony stimulating factor (GM-CSF) and receptors in human endometrium.	CSF2RA CSF3	6.48e-06	2	89	2	10584986
Pubmed	Dual Knockdown of Musashi RNA-Binding Proteins MSI-1 and MSI-2 Attenuates Putative Cancer Stem Cell Characteristics and Therapy Resistance in Ovarian Cancer Cells.	MSI1 MSI2	6.48e-06	2	89	2	34768932
Pubmed	Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function.	GLUD1 GLUD2	6.48e-06	2	89	2	11032875
Pubmed	Six3 and Six6 jointly control diverse target genes in multiple cell populations over developmental trajectories of mouse embryonic retinal progenitor cells.	SIX3 SIX6	6.48e-06	2	89	2	39446806
Pubmed	Molecular analysis of SAR1-related cDNAs from a mouse pituitary cell line.	SAR1B SAR1A	6.48e-06	2	89	2	8262187
Pubmed	SAR1B senses leucine levels to regulate mTORC1 signalling.	SAR1B SAR1A	6.48e-06	2	89	2	34290409
Pubmed	Single amino acid substitution (G456A) in the vicinity of the GTP binding domain of human housekeeping glutamate dehydrogenase markedly attenuates GTP inhibition and abolishes the cooperative behavior of the enzyme.	GLUD1 GLUD2	6.48e-06	2	89	2	11950837
Pubmed	A polymorphism in CCR1/CCR3 is associated with narcolepsy.	CCR1 CCR3	6.48e-06	2	89	2	25986216
Pubmed	Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes.	GLUD1 GLUD2	6.48e-06	2	89	2	29943084
Pubmed	Wnt signaling is regulated by endoplasmic reticulum retention.	PGAP1 SIX3	6.48e-06	2	89	2	19593386
Pubmed	Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins.	MSI1 MSI2	6.48e-06	2	89	2	30097032
Pubmed	Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory.	GLUD1 GLUD2	6.48e-06	2	89	2	31898404
Pubmed	Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.	GLUD1 GLUD2	6.48e-06	2	89	2	15378063
Pubmed	Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.	GLUD1 GLUD2	6.48e-06	2	89	2	27422263
Pubmed	Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.	CBR4 ACSS1 GLUD2 TST	8.43e-06	50	89	4	26058080
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	CBR4 PNPLA6 TPP1 RHBDD2 LPGAT1 COX15 MSI1 KDM1B SAR1A RRP1	1.05e-05	686	89	10	28380382
Pubmed	Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate.	WNT8B SIX3 SIX6	1.52e-05	19	89	3	20890044
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	CBR4 SNED1 BMP2K SLC4A1AP CSPG4 GLUD1 GLUD2 SUPT16H RPS13 PHB2 RHBDD2 SDF2L1 PFKM TIMMDC1	1.85e-05	1451	89	14	30550785
Pubmed	Rescue of calcineurin Aα(-/-) mice reveals a novel role for the α isoform in the salivary gland.	ITPR2 ITPR3	1.94e-05	3	89	2	21435446
Pubmed	Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin.	GLUD1 GLUD2	1.94e-05	3	89	2	29784783
Interaction	NCBP2AS2 interactions	COX20 SAR1B RHBDD2 SAR1A	2.82e-06	23	88	4	int:NCBP2AS2
Cytoband	5q31	KIF20A PCDHGB3 PCDHGA10 PCDHGA2	7.74e-05	115	89	4	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	KIF20A PCDHGB3 PCDHGA10 PCDHGA2 SAR1B	2.96e-04	298	89	5	chr5q31
Cytoband	Xp22.32	ANOS1 CSF2RA	3.84e-04	15	89	2	Xp22.32
Cytoband	10q24	WNT8B COX15	2.12e-03	35	89	2	10q24
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR2 ITPR3	2.92e-05	3	57	2	297
GeneFamily	Phospholipid phosphatase related	PLPPR4 PLPPR3	9.71e-05	5	57	2	1127
GeneFamily	SINE class homeoboxes	SIX3 SIX6	1.45e-04	6	57	2	525
GeneFamily	AAA ATPases\|Mitochondrial respiratory chain complex assembly factors	COX20 COX15 TIMMDC1	2.70e-04	40	57	3	645
GeneFamily	CD molecules\|C-C motif chemokine receptors	CCR1 CCR3	4.32e-04	10	57	2	1091
GeneFamily	Clustered protocadherins	PCDHGB3 PCDHGA10 PCDHGA2	1.08e-03	64	57	3	20
GeneFamily	Acyl-CoA synthetase family	ACSS1 ACSS2	3.02e-03	26	57	2	40
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	SAR1B SAR1A	4.28e-03	31	57	2	357
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PLXNA3 SH3TC1 BMP2K CSAD FAM157C ITPR2	2.01e-06	186	89	6	74c238759c5d3fd39127ec0060d0c2cb16b326d4
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	PLXNA3 SH3TC1 BMP2K CSAD FAM157C ITPR2	2.08e-06	187	89	6	816d37a70f7ec382a268fe828b3dfe737a36a4bf
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SNED1 SALL2 PCDHGA2 KREMEN2 MSI1 FREM1	3.06e-06	200	89	6	29054cf55e88e1ac81a562d8dd9af9b7c749321d
ToppCell	Thalamus-Macroglia-ASTROCYTE\|Thalamus / BrainAtlas - Mouse McCarroll V32	WNT8B GLUD1 TST FREM1 PRDX6	4.49e-06	121	89	5	c3a4dfd19b7e8654e859df605d55155b530ad009
ToppCell	Thalamus-Macroglia-ASTROCYTE-Gja1\|Thalamus / BrainAtlas - Mouse McCarroll V32	WNT8B GLUD1 TST FREM1 PRDX6	4.49e-06	121	89	5	c3efd44bd01c12ef8c7ce4cc351af1540b70a63c
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sncg\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BEND4 RND2 SARDH RGS12 FREM1	7.12e-06	133	89	5	840e8240db29cd21ed9830843c0fa6d65b8f300a
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|367C / Donor, Lineage, Cell class and subclass (all cells)	PLXNA3 SH3TC1 BMP2K FAM157C ITPR2	1.24e-05	149	89	5	41f28138bde45d0b814e116837e5a32b5e80d54a
ToppCell	facs-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CSF2RA PLPPR4 SDF2L1 CCR1 BEND4	2.14e-05	167	89	5	fd84a99ea142d1684cdcf4a88ef1d541760bc78a
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF2RA PLPPR4 WNT8B SDF2L1 BEND4	2.27e-05	169	89	5	735655e75511c5c41aca667909e8bb52a0ad7fc6
ToppCell	droplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CSF2RA PLPPR4 WNT8B SDF2L1 BEND4	2.40e-05	171	89	5	38a05b5ec8ef8f09a2399994c6b4b9a707918ec1
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF20A RNF5 RRP9 KREMEN2 SDF2L1	2.47e-05	172	89	5	dd9ba79e1542fe9fa2c319077d83dd3fc0158f46
ToppCell	COVID-19_Moderate-NK_CD56bright\|COVID-19_Moderate / disease group, cell group and cell class	CDHR1 PYROXD2 LPGAT1 SIX3 WDR72	2.54e-05	173	89	5	a07dcb1e555caaa2235aec219334fcbf2d07f10c
ToppCell	metastatic_Lymph_Node-B_lymphocytes-GC_B_cells_in_the_LZ\|B_lymphocytes / Location, Cell class and cell subclass	SH3TC1 STAC3 SOCS1 PRDX6 BRWD1	3.97e-05	190	89	5	c5c80a6b9087821a2e07250fa90bcd3505f103b6
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3_mon-IPC_like\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	PGAP1 MSI1 RND2 MSI2 ITPR2	4.07e-05	191	89	5	48cffb55c71bb8b34e926fc461fcd345ce43ea00
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3_mon-IPC_like-IPCs\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	PGAP1 MSI1 RND2 MSI2 ITPR2	4.07e-05	191	89	5	e4c1c533771b582e21683dbec6f93a558d865e00
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-IPC_like-IPCs/Immature_PNs\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	PGAP1 RPS13 MSI1 RND2 ITPR2	4.49e-05	195	89	5	5e36a881fe2646f5a95d07d7b9265e6ada38730c
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Stem_cells\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	GRIA4 PFKM SIX3 PRDX6 SIX6	4.49e-05	195	89	5	2fa0216ba493d9722324c0a9a0c59c40e72b3c4e
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Stem_cells-retina_progenitors\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	GRIA4 PFKM SIX3 PRDX6 SIX6	4.49e-05	195	89	5	06a437459717dc3c41ec343b1ec57cf910ecbdd8
ToppCell	wk_20-22-Hematologic-Myeloid-SPP1+_Mac\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CSF2RA BMP2K TPP1 CCR1 ITPR2	4.94e-05	199	89	5	7c19f1b1f4369edd035ca9cdcf4e653771fc4648
ToppCell	5'-Adult-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDHR1 PGAP1 GRIA4 MSI1 FREM1	4.94e-05	199	89	5	f544229f471b4717166dd4b588399afe45cc31b5
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular-Interstitial_macrophage_perivascular_L.1.2.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CSF2RA BMP2K TPP1 CCR1 ITPR2	4.94e-05	199	89	5	4e552015989defc32fe9068e0ba28521b2a1a09c
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-lung_macrophage\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CSF2RA BMP2K TPP1 CCR1 ITPR2	4.94e-05	199	89	5	42d57522aa05892f37790d0039d936e065565359
ToppCell	cellseq2-Immune-Immune_Myeloid-IM-IM\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CSF2RA BMP2K TPP1 STAC3 CCR1	4.94e-05	199	89	5	372fb9eb90022dc4ac770a75b4e207c33d1d0c43
ToppCell	cellseq2-Immune-Immune_Myeloid-IM\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CSF2RA BMP2K TPP1 STAC3 CCR1	4.94e-05	199	89	5	dd3bf59cdc18091889cbf6c43f37100ba537843d
ToppCell	wk_15-18-Hematologic-Myeloid-SPP1+_Mac\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CSF2RA BMP2K TPP1 CCR1 ITPR2	4.94e-05	199	89	5	c7fc2ac1601346aac71e7620a8a440fde8d92dbd
ToppCell	cellseq2-Immune-Immune_Myeloid\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CSF2RA BMP2K TPP1 STAC3 CCR1	4.94e-05	199	89	5	6c3c9eceea20121ae17ae2462134aa0437f591b3
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CSF2RA BMP2K TPP1 CCR1 ITPR2	4.94e-05	199	89	5	0554f41ae53c275c92fe692bd999d7578d244fce
ToppCell	10x3'2.3-week_17-19-Mesenchymal_fibro-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SNED1 ADAMTS19 ANOS1 CSPG4 ANTXR1	5.06e-05	200	89	5	747c61d4e0b746278ae1f45ca4cd556c6961c76a
ToppCell	mLN-Macrophage\|mLN / Region, Cell class and subclass	CSF2RA STAC3 ANTXR1 CCR1 WDFY3	5.06e-05	200	89	5	68d709afd226241e002dae6d6820bccd1cfd87a1
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CSF2RA SH3TC1 STAC3 CCR1 ITPR2	5.06e-05	200	89	5	4b4df0fe47498310d94448b8a289e58e4f5b5aa8
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Mesenchymal\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	SIAE SH3TC1 MTG2 MDH1B SLC25A19	5.06e-05	200	89	5	e5b7d9622b96bb20c81ac76b4e60e8b44fa9cca1
ToppCell	mLN-(6)_Macrophage\|mLN / shred on region, Cell_type, and subtype	CSF2RA STAC3 ANTXR1 CCR1 WDFY3	5.06e-05	200	89	5	6dcba82a7d322102bae205543086e84c7655b3e0
ToppCell	10x3'2.3-week_17-19-Mesenchymal_fibro\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SNED1 ADAMTS19 ANOS1 CSPG4 ANTXR1	5.06e-05	200	89	5	de1d193f773f4e2927baa6fc38d29754b015c6e6
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SH3TC1 BMP2K TPP1 MRPL37 CCR1	5.06e-05	200	89	5	f11ae9055e72c938b6c9e52701478b2eee681ac4
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CACNG3 CSF2RA TPP1 STAC3 CCR1	5.06e-05	200	89	5	a1ae299cf77580a6d1a728ee591888b6d70a19d6
ToppCell	COVID-19_Mild-Neu_3\|World / 5 Neutrophil clusters in COVID-19 patients	TCAF2 PCDHGB3 GLUD2 GRIA4	1.05e-04	122	89	4	2aa9cfadab70312882ae679e3788fc7ab996c0f3
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXNA3 ACSS1 PGAP1 SIX3	1.09e-04	123	89	4	a45d6907c041ad3f3218cd46dccfc25d4bd961cb
Drug	adenine N1-oxide	GLUD1 GLUD2 PFKM	5.55e-07	5	88	3	CID000093557
Drug	N-methylhydantoin	GLUD1 GLUD2 SARDH	1.11e-06	6	88	3	CID000069217
Drug	AC1MQ2IK	GLUD1 GLUD2 ACSS2	3.08e-06	8	88	3	CID003394958
Drug	acetoacetate	NRXN2 GLUD1 GLUD2 COX15 PFKM ACSS2	7.92e-06	122	88	6	CID000000096
Drug	phenyltriethoxysilane	GLUD1 GLUD2	1.48e-05	2	88	2	CID000013075
Drug	methylmercuric bromide	GLUD1 GLUD2	1.48e-05	2	88	2	CID000068175
Drug	5-methylisophthalate	GLUD1 GLUD2	1.48e-05	2	88	2	CID000068137
Drug	adenophostin A	ITPR2 ITPR3	1.48e-05	2	88	2	ctd:C085029
Drug	G-3SH	GLUD1 GLUD2	1.48e-05	2	88	2	CID000174237
Drug	x 1 s	GLUD1 GLUD2	1.48e-05	2	88	2	CID000409694
Drug	iodoacetyldiethylstilbestrol	GLUD1 GLUD2	1.48e-05	2	88	2	CID006455327
Drug	propionyl-AMP	ACSS1 ACSS2	1.48e-05	2	88	2	CID000440863
Drug	2 pc	CSPG4 GLUD1 GLUD2	4.37e-05	18	88	3	CID000440046
Drug	methoxyethylmercury	GLUD1 GLUD2	4.42e-05	3	88	2	CID000115155
Drug	4-methylumbelliferyl laurate	GLUD1 GLUD2	4.42e-05	3	88	2	CID000600674
Drug	methylmercuric iodide	GLUD1 GLUD2	4.42e-05	3	88	2	CID000067347
Drug	HCC-1 variant	CCR1 CCR3	4.42e-05	3	88	2	CID000482146
Drug	lenthionine	GLUD1 GLUD2	4.42e-05	3	88	2	CID000067521
Drug	mildiomycin	GLUD1 GLUD2	4.42e-05	3	88	2	CID000125665
Drug	succinate	CSF3 NRXN2 ACSS1 GLUD1 GLUD2 PFKM ACSS2 TST	5.08e-05	339	88	8	CID000001110
Drug	asparagine	ACSS1 GLUD1 GLUD2 ACSS2	5.28e-05	53	88	4	CID000000236
Drug	AC1L1CVX	PNPLA6 CSF3 GLUD1 GLUD2	8.06e-05	59	88	4	CID000002086
Drug	methyl benzoquate	GLUD1 GLUD2	8.82e-05	4	88	2	CID000026383
Drug	8-BDB-TADP	GLUD1 GLUD2	8.82e-05	4	88	2	CID000130791
Drug	cadina-3,9-diene	GLUD1 GLUD2	8.82e-05	4	88	2	CID000010657
Drug	AC1L9CUQ	GLUD1 GLUD2	8.82e-05	4	88	2	CID000442451
Drug	pentenoic acid	GLUD1 GLUD2	8.82e-05	4	88	2	CID000012299
Drug	alpha-ketoglutaramate	GLUD1 GLUD2	8.82e-05	4	88	2	CID000000048
Drug	luxabendazole	GLUD1 GLUD2	8.82e-05	4	88	2	CID000072019
Drug	ureidoglycine	GLUD1 GLUD2	8.82e-05	4	88	2	CID000439649
Drug	N-butylmaleimide	GLUD1 GLUD2	8.82e-05	4	88	2	CID000239780
Drug	Ivin	GLUD1 GLUD2	8.82e-05	4	88	2	CID000014083
Drug	alpha-methylglutamate	GLUD1 GLUD2	8.82e-05	4	88	2	CID000095440
Drug	2b E2	GLUD1 GLUD2	8.82e-05	4	88	2	CID005327076
Drug	CGP 39653	GLUD1 GLUD2 GRIA4	1.06e-04	24	88	3	CID006437837
Drug	Pyridoxine hydrochloride [58-56-0]; Down 200; 19.4uM; MCF7; HT_HG-U133A	LRIG2 CBR4 SALL2 PNPLA6 RND2 AGBL5	1.17e-04	197	88	6	7171_DN
Drug	Methylhydantoin-5-(D) [55147-68-7]; Up 200; 35uM; MCF7; HT_HG-U133A	TPP1 KREMEN2 GRIA4 WDFY3 RGS12 ITPR2	1.24e-04	199	88	6	3333_UP
Drug	estradiol, USP; Down 200; 0.01uM; MCF7; HT_HG-U133A	PLXNA3 BMP2K TPP1 KREMEN2 PGAP1 WDFY3	1.24e-04	199	88	6	5601_DN
Drug	dimethyl suberimidate	GLUD1 GLUD2 PFKM TST	1.40e-04	68	88	4	CID000034750
Drug	1-pheg	GLUD1 GLUD2	1.47e-04	5	88	2	CID000152041
Drug	5'-FSBAzA	GLUD1 GLUD2	1.47e-04	5	88	2	CID000130430
Drug	bathocuproine	GLUD1 GLUD2	1.47e-04	5	88	2	CID000065149
Drug	choline sulfate	GLUD1 GLUD2	1.47e-04	5	88	2	CID000000485
Drug	l-413	GLUD1 GLUD2	1.47e-04	5	88	2	CID000012475
Drug	AC1NRA4I	GLUD1 GLUD2	1.47e-04	5	88	2	CID005287695
Drug	isosteviol lactone	GLUD1 GLUD2	1.47e-04	5	88	2	CID000401559
Drug	3-aminopicolinate	GLUD1 GLUD2	1.47e-04	5	88	2	CID000073836
Drug	Thimerosal	BMP2K TPP1 CDHR1 PGAP1 SAR1B SUPT16H LPGAT1 COX15 PLPPR3 WDFY3 AGBL5 ITPR3 SIX6 BRWD1	1.95e-04	1199	88	14	ctd:D013849
Drug	p-cumate	ACSS1 ACSS2	2.19e-04	6	88	2	CID000010820
Drug	alpha-monofluoromethylputrescine	GLUD1 GLUD2	2.19e-04	6	88	2	CID000134201
Drug	dadAB	GLUD1 GLUD2	2.19e-04	6	88	2	CID000022626
Drug	diazonium-1-H-tetrazole	GLUD1 GLUD2	2.19e-04	6	88	2	CID000188312
Drug	AC1L448Y	GLUD1 GLUD2	2.19e-04	6	88	2	CID000200389
Drug	2-BDB-TAMP	GLUD1 GLUD2	2.19e-04	6	88	2	CID000127220
Drug	5 fA	ACSS1 ACSS2	2.19e-04	6	88	2	CID000193491
Drug	Emid	GLUD1 GLUD2	2.19e-04	6	88	2	CID000074798
Drug	dimethylmalonate	GLUD1 GLUD2	2.19e-04	6	88	2	CID000007943
Drug	AC1L8SA5	GLUD1 GLUD2	2.19e-04	6	88	2	CID000407285
Drug	2-methyl-1,2,3,4-tetrahydroisoquinoline	GLUD1 GLUD2	2.19e-04	6	88	2	CID000015362
Drug	lanosol	GLUD1 GLUD2	2.19e-04	6	88	2	CID000078659
Drug	isodiazinon	GLUD1 GLUD2	2.19e-04	6	88	2	CID000133913
Drug	AMD3100	ANOS1 CSF3 CCR1 CCR3	2.27e-04	77	88	4	CID000065014
Drug	AC1Q68ZE	ACSS1 GLUD1 GLUD2 ACSS2	2.51e-04	79	88	4	CID000000265
Drug	thionitrobenzoate	GLUD1 GLUD2 TST	2.80e-04	33	88	3	CID000123648
Drug	carbophenothion	GLUD1 GLUD2	3.06e-04	7	88	2	CID000013081
Drug	37474A	GLUD1 GLUD2	3.06e-04	7	88	2	CID004330138
Drug	AC1L1B5W	GLUD1 GLUD2	3.06e-04	7	88	2	CID000001296
Drug	CID10998045	CCR1 CCR3	3.06e-04	7	88	2	CID010998045
Drug	2-oxoglutaconic acid	GLUD1 GLUD2	3.06e-04	7	88	2	CID006443759
Drug	d-serine methyl ester hydrochloride	GLUD1 GLUD2	3.06e-04	7	88	2	CID000090387
Disease	fascioliasis (biomarker_via_orthology)	GLUD1 GLUD2	2.63e-05	3	88	2	DOID:885 (biomarker_via_orthology)
Disease	Sarcosine measurement	PCDHGB3 PCDHGA2 SARDH	4.35e-05	23	88	3	EFO_0021668
Disease	mental development measurement	PCDHGB3 PCDHGA10 PCDHGA2	5.62e-05	25	88	3	EFO_0008230
Disease	childhood absence epilepsy (biomarker_via_orthology)	GLUD1 GLUD2	1.31e-04	6	88	2	DOID:1825 (biomarker_via_orthology)
Disease	xerostomia	ANTXR1 WDR72	2.43e-04	8	88	2	EFO_0009869
Disease	brain ischemia (biomarker_via_orthology)	CSPG4 GLUD1 GLUD2 MSI1	2.51e-04	102	88	4	DOID:2316 (biomarker_via_orthology)
Disease	potassium measurement	SH3TC1 RGS12 WDR72	3.32e-04	45	88	3	EFO_0009283
Disease	refractive error	CDHR1 GRIA4 SIX3 MSI2 ITPR2 SIX6	4.40e-04	326	88	6	MONDO_0004892
Disease	B-Cell Lymphomas	CSF3 SOCS1	5.69e-04	12	88	2	C0079731
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR2 ITPR3	5.69e-04	12	88	2	DOID:1441 (implicated_via_orthology)
Disease	hepatic encephalopathy (biomarker_via_orthology)	GLUD1 GLUD2	9.00e-04	15	88	2	DOID:13413 (biomarker_via_orthology)
Disease	Myopia	GRIA4 SIX6	9.00e-04	15	88	2	C0027092
Disease	childhood trauma measurement, alcohol consumption measurement	PCDHGB3 PCDHGA10 PCDHGA2	1.27e-03	71	88	3	EFO_0007878, EFO_0007979
Disease	Liver diseases	CSF3 SOCS1 CCR1	1.32e-03	72	88	3	C0023895
Disease	Liver Dysfunction	CSF3 SOCS1 CCR1	1.32e-03	72	88	3	C0086565
Disease	acetate measurement	ACSS1 ACSS2	1.61e-03	20	88	2	EFO_0010112
Disease	Anophthalmia-microphthalmia syndrome	SIX3 SIX6	1.78e-03	21	88	2	cv:C5680330
Disease	Hodgkin Disease	CSF3 SOCS1	1.95e-03	22	88	2	C0019829
Disease	arginine measurement	FAM83F PYROXD2	2.14e-03	23	88	2	EFO_0020990
Disease	Cytochrome-c Oxidase Deficiency	COX20 COX15	2.33e-03	24	88	2	C0268237

Protein segments in the cluster

Peptide	Gene	Start	Entry
VLSFVHRFVEGRGAT	AGBL5	136	Q8NDL9
ARIGAVHTVIFAGFS	ACSS1	186	Q9NUB1
FAVDRHSGVLRLQAG	CDHR1	181	Q96JP9
SFQVVVRGNGFRHAR	ANTXR1	236	Q9H6X2
SQVLFSVTRGARHGE	CSPG4	466	Q6UVK1
ATTFRRGFQVTVHVG	GTPBP2	516	Q9BX10
VFSDAVGHARQGRAV	BEND4	486	Q6ZU67
RHNVILSAGIFFVSA	CACNG3	131	O60359
ARIGALHSIVFAGFS	ACSS2	181	Q9NR19
GSSVGVRVFAVGRHQ	BMP2K	36	Q9NSY1
GFSTVFLVRTHGGIR	BMP2K	61	Q9NSY1
TTNRHRGFGFVTFEN	MSI2	146	Q96DH6
QSSHFVGVDGVRAFL	PCDHGA2	736	Q9Y5H1
FNLAGTTVHYVRRGL	ADAMTS19	851	Q8TE59
VFLVSFVGNRGTFTR	ITPR2	2321	Q14571
FVVSFVGNRGTFIRG	ITPR3	2296	Q14573
FIASGRTGRRNAIHD	PKIA	11	P61925
FRVAAVNVHGTRGFT	ANOS1	261	P23352
FTGSAFNRSIHRVFQ	PNPLA6	1061	Q8IY17
NFGIVSLVHGDFFIR	LPGAT1	136	Q92604
LTGGRFRQESHVEFA	HMCN2	4471	Q8NDA2
RFIHGGANVTGFQLV	GRIA4	251	P48058
TYRQHSVVFIGTRSG	PLXNA3	421	P51805
GSHFVGVDGVRAFLQ	PCDHGA10	741	Q9Y5H3
AVVRVGIFTGARVFF	PFKM	36	P08237
HGVVRRAGVTVDQFS	FREM1	936	Q5H8C1
RFIISNGLRTEHGVF	FREM1	1481	Q5H8C1
HVVRFTRSGGNATLQ	NRXN2	1226	Q9P2S2
SSGQHGGRVNLVFFI	FAM157C	351	P0CG43
SARVVGVAHLGEAFR	MYEOV	156	Q96EZ4
LTFRSDARGHAQGFA	KREMEN2	306	Q8NCW0
SVSARSGVVFAQRAF	PCDHGB3	506	Q9Y5G1
VVQSVGTDGRVFHFL	MRPL37	341	Q9BZE1
TNRHRGFGFVTFESE	MSI1	146	O43347
FTVEGGHRAIFFNRI	PHB2	41	Q99623
RQVFGTFHQRTVGHT	CEFIP	61	Q711Q0
IQGTVFFAGEATNRH	KDM1B	786	Q8NB78
SVVAGFGHFLFTSRI	COX20	41	Q5RI15
VHAVFALRARTVTFG	CCR3	136	P51677
VHAVFALRARTVTFG	CCR1	136	P32246
LFRAVSAFGVVGFVR	FIG4	86	Q92562
ATGRGVFHGIENFIN	GLUD1	271	P00367
GRFGETIEVAHAVVF	CBR4	201	Q8N4T8
CVAFDRTGHRIFTGS	BRWD1	191	Q9NSI6
QPHGTRGNFFRVVVA	CSAD	456	Q9Y600
NAHESVRVIVGGRTF	MDH1B	246	Q5I0G3
AFQRRAGGVLVASHL	CSF3	176	P09919
RRFAHGTAGLVFLTA	COX15	261	Q7KZN9
RAFSTRGNLRAHFVG	SALL2	666	Q9Y467
ATGRGVFHGIENFIN	GLUD2	271	P49448
TRAVRAAGYAHGLVF	NEURL4	931	Q96JN8
GVTFEVHVNTSQRGF	CSF2RA	91	P15509
TVFNAHEPFRRGTGV	RNF5	136	Q99942
AASSYGRGRLVVVSH	TCAF2	51	A6NFQ2
IIGGHVSDRFGRRFI	SLC22A10	161	Q63ZE4
ANTTVGRIRFHDFLG	PRDX6	16	P30041
ILRARAVVAFHTGNF	SIX3	131	O95343
ESVLRARAIVAFHGG	SIX6	51	O95475
RETFHRGSQGQTERF	SIAE	301	Q9HAT2
FTTFDLGGHEQARRV	SAR1A	71	Q9NR31
VGRHAASGRVGFVRS	SH3TC1	346	Q8TE82
CFSARLRTVFQGVGH	MTG2	6	Q9H4K7
TSFSQILGQVVRFHG	PGAP1	581	Q75T13
IVARTQRAAGGFTHD	RRP1	36	P56182
EAHVNGFRFTSVRGD	SUPT16H	681	Q9Y5B9
SGPTSIRVHFQAGRF	SOCS1	121	O15524
TGFYRGVSRVTLFTH	FAM83F	126	Q8NEG4
GQVVGHVRRADFGFA	SARDH	846	Q9UL12
HATLRFNGTRLGAVA	SNED1	706	Q8TER0
FLRRAVRFVGVHVFG	PLPPR4	171	Q7Z2D5
RDVFHVATVASLGRG	RND2	171	P52198
GGLRSANRETAFVHA	WNT8B	76	Q93098
NGVYTLNFHGRVTRA	TULP2	456	O00295
VAGFRGTVRYASVNA	TTBK1	196	Q5TCY1
IFREFGGARCAHNIV	WDFY3	566	Q8IZQ1
IHQGIARRFGFECTA	RGS12	351	O14924
REAAVRFQHVGTSVF	SDF2L1	156	Q9HCN8
RFQHVGTSVFLSVTG	SDF2L1	161	Q9HCN8
AVFERRHVIGGAAVT	PYROXD2	61	Q8N2H3
TFTGHRDAVSGLAFR	RRP9	236	O43818
RDAVSGLAFRRGTHQ	RRP9	241	O43818
FLRRTVRFVGVHVFG	PLPPR3	126	Q6T4P5
ERGIGQATHRFTFSQ	KIF20A	111	O95235
FAGNFERTVGTVRHC	RHBDD2	86	Q6NTF9
GVILRDSHGVAQVRF	RPS13	51	P62277
SHFVIAGAVTGSLFR	TIMMDC1	166	Q9NPL8
QFFAGGEVIAAHRIL	WDR72	256	Q3MJ13
FRVFGHRTVSVLNGG	TST	116	Q16762
FTTFDLGGHVQARRV	SAR1B	71	Q9Y6B6
AGERVHRVTRSFVGN	STAC3	306	Q96MF2
VGGFEHARAAFGQVR	SLC25A19	246	Q9HC21
LFGGNFAHQASVARV	TPP1	246	O14773
RVTHIADGVFRFLSN	LRIG2	346	O94898
HVVRFGGSTRLFILQ	SLC4A1AP	261	Q9BWU0