Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesspositive regulation of cell adhesion

EPHB4 ARID1B COL16A1 ARID2 RIPK2 TRIOBP LAMB2 NFKBIZ IL2RG

2.75e-05579579GO:0045785
GeneOntologyBiologicalProcesspositive regulation of aorta morphogenesis

EPHB4 NOTCH4

4.49e-054572GO:1903849
GeneOntologyBiologicalProcesspositive regulation of T cell differentiation

ARID1B ARID2 RIPK2 NFKBIZ IL2RG

4.84e-05144575GO:0045582
GeneOntologyBiologicalProcesspositive regulation of lymphocyte differentiation

ARID1B ARID2 RIPK2 NFKBIZ IL2RG

8.46e-05162575GO:0045621
GeneOntologyBiologicalProcessregulation of lymphocyte differentiation

ARID1B ARID2 RIPK2 NFKBIZ NFAM1 IL2RG

9.09e-05266576GO:0045619
GeneOntologyBiologicalProcessbehavioral response to pain

P2RX2 SCN9A SCN10A

9.38e-0532573GO:0048266
GeneOntologyBiologicalProcessregulation of aorta morphogenesis

EPHB4 NOTCH4

1.12e-046572GO:1903847
GeneOntologyBiologicalProcesspositive regulation of T cell activation

EPHB4 ARID1B ARID2 RIPK2 NFKBIZ IL2RG

1.46e-04290576GO:0050870
GeneOntologyBiologicalProcessregulation of cell adhesion

EPHB4 ARID1B COL16A1 ARID2 RIPK2 TRIOBP LAMB2 NFKBIZ IL2RG NOTCH4

2.02e-049275710GO:0030155
GeneOntologyBiologicalProcesspositive regulation of leukocyte cell-cell adhesion

EPHB4 ARID1B ARID2 RIPK2 NFKBIZ IL2RG

2.36e-04317576GO:1903039
GeneOntologyBiologicalProcesspositive regulation of CD4-positive, alpha-beta T cell differentiation

RIPK2 NFKBIZ IL2RG

2.61e-0445573GO:0043372
GeneOntologyBiologicalProcesspositive regulation of artery morphogenesis

EPHB4 NOTCH4

2.67e-049572GO:1905653
GeneOntologyBiologicalProcessCD4-positive, alpha-beta T cell differentiation

RIPK2 KMT2A NFKBIZ IL2RG

3.29e-04119574GO:0043367
GeneOntologyBiologicalProcessleukocyte cell-cell adhesion

EPHB4 ARID1B ARID2 RIPK2 NFKBIZ IL2RG ITGB7

3.69e-04486577GO:0007159
GeneOntologyBiologicalProcessresponse to pain

P2RX2 SCN9A SCN10A

3.79e-0451573GO:0048265
GeneOntologyBiologicalProcessregulation of T cell differentiation

ARID1B ARID2 RIPK2 NFKBIZ IL2RG

3.98e-04226575GO:0045580
GeneOntologyBiologicalProcessalpha-beta T cell activation

RIPK2 KMT2A NFKBIZ IL2RG WDFY4

4.06e-04227575GO:0046631
GeneOntologyBiologicalProcesssensory perception of mechanical stimulus

P2RX2 SCN9A SCN10A TRIOBP KCNQ1

5.04e-04238575GO:0050954
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception

SCN9A SCN10A KCNQ1

5.27e-0457573GO:0050974
GeneOntologyBiologicalProcesspost-embryonic development

FOXP2 MYT1 SCN9A KMT2A

5.30e-04135574GO:0009791
GeneOntologyBiologicalProcesspositive regulation of leukocyte differentiation

ARID1B ARID2 RIPK2 NFKBIZ IL2RG

5.43e-04242575GO:1902107
GeneOntologyBiologicalProcesspositive regulation of hemopoiesis

ARID1B ARID2 RIPK2 NFKBIZ IL2RG

5.43e-04242575GO:1903708
GeneOntologyBiologicalProcesspositive regulation of CD4-positive, alpha-beta T cell activation

RIPK2 NFKBIZ IL2RG

5.54e-0458573GO:2000516
GeneOntologyBiologicalProcessvenous blood vessel morphogenesis

EPHB4 NOTCH4

5.74e-0413572GO:0048845
GeneOntologyBiologicalProcessT cell differentiation

ARID1B ARID2 RIPK2 KMT2A NFKBIZ IL2RG

6.35e-04382576GO:0030217
GeneOntologyBiologicalProcessT cell activation

EPHB4 ARID1B ARID2 RIPK2 KMT2A NFKBIZ IL2RG WDFY4

6.49e-04701578GO:0042110
GeneOntologyBiologicalProcesspositive regulation of lymphocyte activation

EPHB4 ARID1B ARID2 RIPK2 NFKBIZ IL2RG

6.61e-04385576GO:0051251
GeneOntologyBiologicalProcesslymphocyte differentiation

ARID1B ARID2 RIPK2 KMT2A NFKBIZ NFAM1 IL2RG

6.68e-04537577GO:0030098
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

SCN9A SCN10A KCNQ1

6.74e-0462573GO:0086002
GeneOntologyBiologicalProcessregulation of hemopoiesis

ARID1B L3MBTL1 ARID2 RIPK2 NFKBIZ NFAM1 IL2RG

6.90e-04540577GO:1903706
GeneOntologyBiologicalProcesspositive regulation of cell-cell adhesion

EPHB4 ARID1B ARID2 RIPK2 NFKBIZ IL2RG

6.98e-04389576GO:0022409
GeneOntologyBiologicalProcessbehavior

NCOA2 LRRC66 FOXP2 P2RX2 SCN9A SCN10A KCNQ1 KMT2A ALK

7.01e-04891579GO:0007610
GeneOntologyBiologicalProcessneuronal action potential

P2RX2 SCN9A SCN10A

7.06e-0463573GO:0019228
GeneOntologyBiologicalProcesspositive regulation of alpha-beta T cell differentiation

RIPK2 NFKBIZ IL2RG

7.40e-0464573GO:0046638
GeneOntologyBiologicalProcessCD4-positive, alpha-beta T cell activation

RIPK2 KMT2A NFKBIZ IL2RG

8.47e-04153574GO:0035710
GeneOntologyBiologicalProcessembryonic organ development

GLI1 ARID2 TRIOBP KCNQ1 KMT2A COBL PBX4

8.64e-04561577GO:0048568
GeneOntologyBiologicalProcessalpha-beta T cell differentiation

RIPK2 KMT2A NFKBIZ IL2RG

9.33e-04157574GO:0046632
GeneOntologyBiologicalProcessregulation of artery morphogenesis

EPHB4 NOTCH4

9.94e-0417572GO:1905651
GeneOntologyBiologicalProcessregulation of cell-cell adhesion

EPHB4 ARID1B ARID2 RIPK2 NFKBIZ IL2RG NOTCH4

1.05e-03580577GO:0022407
GeneOntologyBiologicalProcesspositive regulation of leukocyte activation

EPHB4 ARID1B ARID2 RIPK2 NFKBIZ IL2RG

1.08e-03423576GO:0002696
GeneOntologyBiologicalProcessinner ear receptor cell development

CECR2 TRIOBP KCNQ1

1.09e-0373573GO:0060119
GeneOntologyBiologicalProcessregulation of CD4-positive, alpha-beta T cell differentiation

RIPK2 NFKBIZ IL2RG

1.09e-0373573GO:0043370
GeneOntologyBiologicalProcessregulation of leukocyte differentiation

ARID1B ARID2 RIPK2 NFKBIZ NFAM1 IL2RG

1.16e-03429576GO:1902105
GeneOntologyBiologicalProcessdetection of mechanical stimulus

SCN9A SCN10A KCNQ1

1.17e-0375573GO:0050982
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

NCOA2 MED4 SGSM1 GLI1 ARID2 MYT1 RIPK2 KMT2A NFKBIZ NOTCH4 CRTC2

1.30e-0313905711GO:0045944
GeneOntologyBiologicalProcesslymphocyte activation

EPHB4 ARID1B ARID2 RIPK2 KMT2A NFKBIZ NFAM1 IL2RG WDFY4

1.33e-03976579GO:0046649
GeneOntologyBiologicalProcessvenous blood vessel development

EPHB4 NOTCH4

1.38e-0320572GO:0060841
GeneOntologyBiologicalProcessregulation of leukocyte cell-cell adhesion

EPHB4 ARID1B ARID2 RIPK2 NFKBIZ IL2RG

1.43e-03447576GO:1903037
GeneOntologyBiologicalProcessregulation of lymphocyte activation

EPHB4 ARID1B ARID2 RIPK2 NFKBIZ NFAM1 IL2RG

1.46e-03614577GO:0051249
GeneOntologyBiologicalProcesspositive regulation of cell activation

EPHB4 ARID1B ARID2 RIPK2 NFKBIZ IL2RG

1.46e-03449576GO:0050867
DomainSAM_1

EPHB4 L3MBTL1 SAMD4A ANKS1A

4.77e-0568554PF00536
DomainGrowth_fac_rcpt_

EPHB4 HMCN1 LAMB2 ADGRE1 NOTCH4

9.47e-05156555IPR009030
DomainEGF-like_CS

EPHB4 HMCN1 LAMB2 ADGRE1 ITGB7 NOTCH4

1.15e-04261556IPR013032
DomainEGF_2

EPHB4 HMCN1 LAMB2 ADGRE1 ITGB7 NOTCH4

1.25e-04265556PS01186
DomainZnf_C2HC

L3MBTL1 MYT1

1.27e-046552IPR002515
Domainzf-C2HC

L3MBTL1 MYT1

1.27e-046552PF01530
DomainSAM

EPHB4 L3MBTL1 SAMD4A ANKS1A

1.31e-0488554SM00454
DomainSAM_DOMAIN

EPHB4 L3MBTL1 SAMD4A ANKS1A

1.76e-0495554PS50105
DomainZF_CCHHC

L3MBTL1 MYT1

1.77e-047552PS51802
DomainSAM

EPHB4 L3MBTL1 SAMD4A ANKS1A

1.90e-0497554IPR001660
Domain-

EPHB4 L3MBTL1 SAMD4A ANKS1A

2.68e-041065541.10.150.50
DomainNa_channel_asu

SCN9A SCN10A

3.77e-0410552IPR001696
DomainNa_trans_assoc

SCN9A SCN10A

3.77e-0410552IPR010526
DomainNa_trans_assoc

SCN9A SCN10A

3.77e-0410552PF06512
DomainSAM/pointed

EPHB4 L3MBTL1 SAMD4A ANKS1A

3.90e-04117554IPR013761
Domain-

ARID1B ARID2

8.72e-04155521.10.150.60
DomainBRIGHT

ARID1B ARID2

8.72e-0415552SM00501
DomainARID_dom

ARID1B ARID2

8.72e-0415552IPR001606
DomainARID

ARID1B ARID2

8.72e-0415552PS51011
DomainARID

ARID1B ARID2

8.72e-0415552PF01388
DomainEGF_1

HMCN1 LAMB2 ADGRE1 ITGB7 NOTCH4

9.09e-04255555PS00022
DomainAT_hook

CECR2 KMT2A

9.95e-0416552PF02178
DomainEGF_CA

HMCN1 ADGRE1 NOTCH4

2.08e-0386553PF07645
DomainZnf_C2H2-like

ZNF8 ZSCAN20 FOXP2 ZNF584 GLI1 ZFR2 ARID2 ZNF423

2.17e-03796558IPR015880
DomainZnf_C2H2

ZNF8 ZSCAN20 FOXP2 ZNF584 GLI1 ZFR2 ARID2 ZNF423

2.33e-03805558IPR007087
DomainZnF_C2H2

ZNF8 ZSCAN20 FOXP2 ZNF584 GLI1 ZFR2 ARID2 ZNF423

2.38e-03808558SM00355
DomaincEGF

HMCN1 ADGRE1

2.64e-0326552IPR026823
DomaincEGF

HMCN1 ADGRE1

2.64e-0326552PF12662
DomainEGF_Ca-bd_CS

HMCN1 ADGRE1 NOTCH4

2.93e-0397553IPR018097
DomainEGF_CA

HMCN1 ADGRE1 NOTCH4

3.10e-0399553PS01187
DomainASX_HYDROXYL

HMCN1 ADGRE1 NOTCH4

3.19e-03100553PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

HMCN1 ADGRE1 NOTCH4

3.76e-03106553IPR000152
DomainIon_trans_dom

SCN9A SCN10A KCNQ1

4.61e-03114553IPR005821
DomainIon_trans

SCN9A SCN10A KCNQ1

4.61e-03114553PF00520
DomainEGF

HMCN1 LAMB2 ADGRE1 NOTCH4

5.04e-03235554SM00181
DomainEGF_CA

HMCN1 ADGRE1 NOTCH4

5.57e-03122553SM00179
DomainEGF-like_Ca-bd_dom

HMCN1 ADGRE1 NOTCH4

5.83e-03124553IPR001881
DomainEGF-like_dom

HMCN1 LAMB2 ADGRE1 NOTCH4

6.18e-03249554IPR000742
DomainBROMODOMAIN_2

CECR2 KMT2A

6.49e-0341552PS50014
DomainPkinase_Tyr

EPHB4 RIPK2 ALK

6.50e-03129553PF07714
DomainBROMO

CECR2 KMT2A

6.80e-0342552SM00297
DomainBromodomain

CECR2 KMT2A

6.80e-0342552IPR001487
Domain-

CECR2 KMT2A

6.80e-03425521.20.920.10
DomainZINC_FINGER_C2H2_2

ZNF8 ZSCAN20 FOXP2 ZNF584 GLI1 ARID2 ZNF423

7.40e-03775557PS50157
DomainZINC_FINGER_C2H2_1

ZNF8 ZSCAN20 FOXP2 ZNF584 GLI1 ARID2 ZNF423

7.50e-03777557PS00028
DomainSer-Thr/Tyr_kinase_cat_dom

EPHB4 RIPK2 ALK

7.82e-03138553IPR001245
Pubmed

Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8.

SCN9A SCN10A

2.64e-06257216111501
Pubmed

Specificity of interleukin-2 receptor gamma chain superfamily cytokines is mediated by insulin receptor substrate-dependent pathway.

IRS4 IL2RG

2.64e-06257211788580
Pubmed

The cell and molecular basis of mechanical, cold, and inflammatory pain.

SCN9A SCN10A

7.91e-06357218669863
Pubmed

Genome-Wide Transcriptional Regulation Mediated by Biochemically Distinct SWI/SNF Complexes.

ARID1B ARID2

7.91e-06357226716708
Pubmed

Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.

SCN9A SCN10A

7.91e-06357219699781
Pubmed

Sodium channels and mammalian sensory mechanotransduction.

SCN9A SCN10A

7.91e-06357222449024
Pubmed

Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1.

SCN10A KCNQ1

7.91e-06357226971948
Pubmed

Sodium channel Na(v)1.7 is essential for lowering heat pain threshold after burn injury.

SCN9A SCN10A

7.91e-06357222875917
Pubmed

Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Nav1.7 knockout mice.

SCN9A SCN10A

7.91e-06357228074005
Pubmed

Genetic Analysis of SCN11A, SCN10A, and SCN9A in Familial Episodic Pain Syndrome (FEPS) in Japan and Proposal of Clinical Diagnostic Criteria.

SCN9A SCN10A

7.91e-06357238999942
Pubmed

Differential roles of BAF and PBAF subunits, Arid1b and Arid2, in MLL-AF9 leukemogenesis.

ARID1B ARID2

7.91e-06357235022500
Pubmed

Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain.

SCN9A SCN10A

7.91e-06357215314237
Pubmed

Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer.

ARID1B ARID2

7.91e-06357224382590
Pubmed

Yield of peripheral sodium channels gene screening in pure small fibre neuropathy.

SCN9A SCN10A

7.91e-06357230554136
Pubmed

Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance.

KMT2A IL2RG

7.91e-06357232763164
Pubmed

ARID1A, ARID1B, and ARID2 Mutations Serve as Potential Biomarkers for Immune Checkpoint Blockade in Patients With Non-Small Cell Lung Cancer.

ARID1B ARID2

7.91e-06357234512623
Pubmed

Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis.

SCN9A SCN10A

1.58e-05457238172636
Pubmed

Dynamic changes occur in patterns of endometrial EFNB2/EPHB4 expression during the period of spiral arterial modification in mice.

EPHB4 IL2RG

1.58e-05457218463357
Pubmed

Evolution and diversity of mammalian sodium channel genes.

SCN9A SCN10A

1.58e-05457210198179
Pubmed

Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.

SCN9A SCN10A

1.58e-05457222260870
Pubmed

Acute Myeloid Leukemia Alters Group 1 Innate Lymphoid Cell Differentiation from a Common Precursor.

KMT2A IL2RG

1.58e-05457234417259
Pubmed

Analgesic targets identified in mouse sensory neuron somata and terminal pain translatomes.

SCN9A SCN10A

1.58e-05457239163201
Pubmed

Nedd4-2 haploinsufficiency causes hyperactivity and increased sensitivity to inflammatory stimuli.

SCN9A SCN10A

1.58e-05457227604420
Pubmed

Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons.

SCN9A SCN10A

1.58e-05457222531176
Pubmed

Interaction network of human early embryonic transcription factors.

NCOA2 ARID1B FOXP2 ARID2 ZNF423 KMT2A

2.38e-0535157638297188
Pubmed

Notch4 normalization reduces blood vessel size in arteriovenous malformations.

EPHB4 NOTCH4

2.63e-05557222261032
Pubmed

Recent advances in understanding chromatin remodeling by Swi/Snf complexes.

ARID1B ARID2

2.63e-05557212672490
Pubmed

Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy.

IL2RG ITGB7

2.63e-0555729421796
Pubmed

Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function.

SCN9A SCN10A

2.63e-05557237117223
Pubmed

Protein interactome reveals converging molecular pathways among autism disorders.

L3MBTL1 FOXP2 ZNF423 ARHGAP44 TRIOBP LAMB2 COBL

3.56e-0556057721653829
Pubmed

Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons.

SCN9A SCN10A

3.94e-05657216029194
Pubmed

ARID1B maintains mesenchymal stem cell quiescence via inhibition of BCL11B-mediated non-canonical Activin signaling.

ARID1B GLI1

3.94e-05657238816354
Pubmed

Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.

FOXP2 IL2RG

3.94e-05657228591638
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN9A SCN10A

3.94e-05657223652591
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

NCOA2 ZSCAN20 FOXP2 ARID2 ZNF423 MYT1 PBX4 NFKBIZ

4.96e-0580857820412781
Pubmed

Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis.

EPHB4 NOTCH4

5.51e-05757218952909
Pubmed

Pain without nociceptors? Nav1.7-independent pain mechanisms.

SCN9A SCN10A

5.51e-05757224440715
Pubmed

Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing.

IL2RG ITGB7

5.51e-05757211696590
Pubmed

A role for Piezo2 in EPAC1-dependent mechanical allodynia.

SCN9A SCN10A

5.51e-05757223575686
Pubmed

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.

IRS4 PARD3B CRTC2 SAMD4A ANKS1A

6.25e-0525557515324660
Pubmed

Significant determinants of mouse pain behaviour.

SCN9A SCN10A

7.34e-05857225101983
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

IRS4 RIPK2 KMT2A COBL PARD3B CRTC2 SAMD4A ANKS1A

7.72e-0586157836931259
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

P2RX2 SCN9A SCN10A KCNQ1

8.19e-0513957416985003
Pubmed

Coffin-Siris Syndrome

ARID1B ARID2

9.43e-05957223556151
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN9A SCN10A

9.43e-05957216382098
Pubmed

A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma.

GAGE2B GAGE2A

9.43e-0595727544395
Pubmed

Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse.

SCN9A SCN10A

9.43e-0595728854872
Pubmed

Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs.

GLI1 IL2RG

9.43e-05957232075728
Pubmed

Bone marrow endosteal stem cells dictate active osteogenesis and aggressive tumorigenesis.

GLI1 IL2RG

9.43e-05957237185464
Pubmed

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

NCOA2 SCN10A KCNQ1

1.15e-045757324952745
Pubmed

Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations.

SCN10A KCNQ1

1.18e-041057225055868
Pubmed

Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.

ARID1B KMT2A

1.18e-041057212665591
Pubmed

Nomenclature of the ARID family of DNA-binding proteins.

ARID1B ARID2

1.18e-041057215922553
Pubmed

ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF.

ARID1B ARID2

1.18e-041057223129809
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

USP42 CECR2 KMT2A NFKBIZ PARD3B ANKS1A

1.18e-0446957627634302
Pubmed

A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.

ARID1B ARID2 KMT2A

1.40e-046157320305087
Pubmed

Early postnatal serotonin modulation prevents adult-stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming.

ARID1B FOXP2

1.44e-041157236030255
Pubmed

Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.

NCOA2 ANKS1A

1.44e-041157223144319
Pubmed

Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development.

ARID1B FOXP2 ARID2

1.70e-046557326655900
Pubmed

MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program.

KMT2A NFAM1

1.72e-041257227462455
Pubmed

Delta-like ligand-4 regulates Notch-mediated maturation of second heart field progenitor-derived pharyngeal arterial endothelial cells.

EPHB4 NOTCH4

1.72e-041257236082581
Pubmed

Etv4 regulates nociception by controlling peptidergic sensory neuron development and peripheral tissue innervation.

SCN9A SCN10A

2.03e-041357235904071
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN9A SCN10A

2.03e-041357215123669
Pubmed

Several common variants modulate heart rate, PR interval and QRS duration.

SCN10A KCNQ1

2.37e-041457220062063
Pubmed

Zfp423/ZNF423 regulates cell cycle progression, the mode of cell division and the DNA-damage response in Purkinje neuron progenitors.

ZNF423 LAMB2

2.37e-041457228893945
Pubmed

P53 independent pathogenic mechanisms contribute to BubR1 microcephaly.

FOXP2 ADGRE1

2.37e-041457237900274
Pubmed

Combinatorial CRISPR screen identifies fitness effects of gene paralogues.

ARID1B USP42 KMT2A DSN1

2.51e-0418657433637726
Pubmed

The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer.

IRS4 FOXP2 MYT1

2.59e-047557337298722
Pubmed

Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity.

KMT2A IL2RG

2.73e-041557238413714
Pubmed

Lymphatic mimicry in maternal endothelial cells promotes placental spiral artery remodeling.

ADGRE1 IL2RG

2.73e-041557231415243
Pubmed

Sonic hedgehog expressing and responding cells generate neuronal diversity in the medial amygdala.

FOXP2 GLI1

3.53e-041757220507551
Pubmed

An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis.

FOXP2 ADGRE1

3.53e-041757236604424
Pubmed

The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes.

ARID1B ARID2

3.53e-041757211078522
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

NCOA2 IRS4 KMT2A COBL

3.83e-0420857433230847
Pubmed

The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development.

EPHB4 NOTCH4

3.97e-041857216678147
Pubmed

Loss of the ciliary protein Chibby1 in mice leads to exocrine pancreatic degeneration and pancreatitis.

GLI1 ADGRE1

3.97e-041857234446743
Pubmed

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling.

EPHB4 NOTCH4

3.97e-041857218093989
Pubmed

Loss of endogenous thymosin β4 accelerates glomerular disease.

GLI1 ADGRE1

3.97e-041857227575556
Pubmed

RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways.

NCOA2 GLI1

3.97e-041857214687547
Pubmed

Analysis of expansion of myeloid progenitors in mice to identify leukemic susceptibility genes.

IL2RG NOTCH4

3.97e-041857216897342
Pubmed

The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling.

EPHB4 NOTCH4

4.43e-041957220627076
Pubmed

Coronary arteries form by developmental reprogramming of venous cells.

EPHB4 NOTCH4

4.43e-041957220336138
Pubmed

Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes.

ARID1B ARID2

4.43e-041957212110891
Pubmed

Sox17 is indispensable for acquisition and maintenance of arterial identity.

EPHB4 NOTCH4

4.92e-042057224153254
Pubmed

Programmed cell senescence during mammalian embryonic development.

GLI1 ADGRE1

5.43e-042157224238962
Pubmed

ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons.

SCN9A SCN10A

5.43e-042157225369838
Pubmed

Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions.

FOXP2 GLI1

5.43e-042157229659575
Pubmed

A Transcription Factor Etv1/Er81 Is Involved in the Differentiation of Sweet, Umami, and Sodium Taste Cells.

P2RX2 KCNQ1

5.43e-042157237045597
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

NCOA2 MED4 POLR3E ZNF584 GLI1 PBX4 NFKBIZ

5.59e-0487757720211142
Pubmed

The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus.

FOXP2 GLI1

5.97e-042257237532091
Pubmed

Klf2 is an essential regulator of vascular hemodynamic forces in vivo.

EPHB4 NOTCH4

5.97e-042257217141159
Pubmed

Vertebrate lonesome kinase modulates the hepatocyte secretome to prevent perivascular liver fibrosis and inflammation.

GLI1 ADGRE1

5.97e-042257235293576
Pubmed

Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid.

P2RX2 GLI1

5.97e-042257228715412
Pubmed

Embryonic cholecystitis and defective gallbladder contraction in the Sox17-haploinsufficient mouse model of biliary atresia.

GLI1 ADGRE1

5.97e-042257228432216
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

P2RX2 ALK ITGB7

6.21e-0410157323382219
Pubmed

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

L3MBTL1 ARHGAP44 COBL

6.39e-041025739734811
Pubmed

Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.

PARD3B SAMD4A ANKS1A

6.39e-0410257315778465
Pubmed

FET family fusion oncoproteins target the SWI/SNF chromatin remodeling complex.

ARID1B ARID2

6.53e-042357230962207
Pubmed

Cerebellar cortical lamination and foliation require cyclin A2.

FOXP2 GLI1

6.53e-042357224184637
Pubmed

Diversity and specialization of mammalian SWI/SNF complexes.

ARID1B ARID2

6.53e-04235728804307
GeneFamilySterile alpha motif domain containing

EPHB4 L3MBTL1 SAMD4A ANKS1A

5.59e-0588434760
GeneFamilySodium voltage-gated channel alpha subunits

SCN9A SCN10A

1.97e-0494321203
GeneFamilyAT-rich interaction domain containing

ARID1B ARID2

5.69e-0415432418
ToppCelldroplet-Bladder-nan-3m-Hematologic-leukocyte|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRE1 NFAM1 IL2RG WDFY4 ITGB7

1.93e-061635652f32a9ab0230fdca98ffa7fd59397301d50e4f30
ToppCelldroplet-Bladder-nan-3m-Hematologic|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRE1 NFAM1 IL2RG WDFY4 ITGB7

1.93e-061635656c2967dee563295febe2adabf503d095cb911ccf
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D122|Adult / Lineage, Cell type, age group and donor

EPHB4 HMCN1 ZNF423 CCDC188 NOTCH4

2.24e-061685658c3e1e45b422813bcdfa4273b1167db649a312f5
ToppCellIIF-Myeloid-pDC|IIF / Disease, Lineage and Cell Type

P2RX2 SCN9A COBL CCDC188 NOTCH4

2.73e-0617556535cfb7d0b88678ff5b83ad6e19dbc15a908a3fcc
ToppCell(0)_Myeloid-(01)_Dendritic_cell|(0)_Myeloid / immune cells in Peripheral Blood (logTPM normalization)

NCOA2 SCN9A IL2RG WDFY4 ITGB7

4.09e-06190565e9507bb0c8ff3d071402731a9b8cfe1bba93fab0
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

NCOA2 ARID1B FOXP2 ARHGAP44 PARD3B

5.00e-061985651996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellcontrol-unassigned|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

NFAM1 DSN1 NOTCH4 FAN1 ANKS1A

5.12e-0619956550e2da35edff1aadef939cfbd4549f73c1a07717
ToppCellcontrol-unassigned|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

NFAM1 DSN1 NOTCH4 FAN1 ANKS1A

5.12e-061995655db7c8089172ac8e796613b3cef618d87007a0ab
ToppCellMS-Multiple_Sclerosis-Lymphocyte-T/NK-ILC|Multiple_Sclerosis / Disease, condition lineage and cell class

ARHGAP44 SCN9A NOTCH4 SPATC1L FAN1

5.25e-06200565ab9bdc9365cbdffe4ed246ce0c8a008a390e387e
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYT1 SCN9A SCN10A CSMD3

3.34e-0514556496712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellPND07-Immune-Immune_Myeloid-DC-cDC2|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ADGRE1 NFAM1 WDFY4 ITGB7

3.71e-0514956432e0be7da42d26956683b21a1e7ae6915e4c16fb
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Arhgap36_Hmcn1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

HMCN1 SLC44A5 SCN9A CSMD3

4.12e-051535649c6fce56300ba5053efda59a438d63a808c497c0
ToppCellTCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue-Thryoid_normal_tissue-3|TCGA-Thryoid / Sample_Type by Project: Shred V9

FOXP2 GLI1 CECR2 PBX4

4.22e-051545644e9203c220a44c70cd7979796a0b461991422257
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Myeloid-macrophage|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRE1 NFAM1 WDFY4 ITGB7

4.44e-05156564c841faa1695ff577b0774f531adf1343d05dce9e
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Myeloid|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRE1 NFAM1 WDFY4 ITGB7

4.44e-0515656421baf8c6e62bb7fd1530c2c100f73c0cecee092e
ToppCellCOVID_non-vent-Lymphocytic-Dendritic-pDC|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

SCN9A COBL WDFY4 NOTCH4

4.90e-0516056461f4cb4eb4313d8318aadbb99595a6cb7fd919f7
ToppCellCOVID_non-vent-Lymphocytic-Dendritic|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

SCN9A COBL WDFY4 NOTCH4

4.90e-0516056434b4f710cfcb6ec370b8b074f3cbfe272f392cec
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Myeloid-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRE1 NFAM1 WDFY4 ITGB7

5.14e-051625644c6e0cadd0ff50b0f50e0cfdc9027210e72674b9
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MYT1 SCN9A SCN10A CSMD3

5.14e-05162564bf886e22ff2a20353499004b53f25fb9e6574896
ToppCelldroplet-Liver-LIVER-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFKBIZ ADGRE1 NFAM1 IL2RG

5.39e-05164564939d4e3911fce185b986639c815de0a0389f6cfd
ToppCelldroplet-Liver-LIVER-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFKBIZ ADGRE1 NFAM1 IL2RG

5.39e-051645643281f2452cc6b11f3e030a3942002b9457dde6fe
ToppCell356C-Myeloid-Monocyte-CD16+_Monocyte|356C / Donor, Lineage, Cell class and subclass (all cells)

ARID1B ZNF584 ADGRE1 SPATC1L

5.52e-0516556435a6de30438de364ccca948fc932da541a69ef89
ToppCellfacs-Lung-3m-Hematologic-myeloid|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADGRE1 NFAM1 WDFY4 ITGB7

5.65e-051665647bf7c2854cf7d85b3ae07256bbe86ae9184d6b57
ToppCell356C-Myeloid-Monocyte-CD16+_Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ARID1B ZNF584 ADGRE1 SPATC1L

5.79e-051675647e61c5d2cdcfa6a2e3484b3994aec6b64ad75f07
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Arhgap36_Hmcn1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

HMCN1 SLC44A5 SCN9A CSMD3

5.79e-051675641c1b4722c6c0eff85a9b32ca7b4e281caebf63b0
ToppCelldroplet-Liver-LIVER-30m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFKBIZ ADGRE1 NFAM1 IL2RG

5.79e-05167564a038c522e4783cb62802f613d00bd5f3e3797199
ToppCelldroplet-Bladder-BLADDER-1m-Hematologic-leukocyte|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRE1 NFAM1 WDFY4 ITGB7

6.06e-05169564b46e446067c6425bd5b8ef7719aeecff5e861249
ToppCelldroplet-Bladder-BLADDER-1m-Hematologic|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRE1 NFAM1 WDFY4 ITGB7

6.06e-051695645508b03fbf483fce7701d6c82c297ffda3b1ba05
ToppCellControl-Epithelial_cells-ECM-high_epithelial|Control / group, cell type (main and fine annotations)

ARHGAP44 COBL PARD3B SAMD4A

6.20e-05170564e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCelldroplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRRC66 NFAM1 WDFY4 ITGB7

6.20e-05170564138235227fc4c3d660c3a06e8e5167bf64f076b3
ToppCellCOVID-pDC|COVID / Condition, Cell_class and T cell subcluster

SCN9A COBL DSN1 NOTCH4

6.49e-051725643ecbb000495dde32f6153ef6bdea9c8802ff3985
ToppCellCOVID-pDC-|COVID / Condition, Cell_class and T cell subcluster

SCN9A COBL DSN1 NOTCH4

6.49e-05172564a7827faa1afab51fdaf0cb1a2babcd2e00d411e5
ToppCelldroplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRRC66 NFAM1 WDFY4 ITGB7

6.63e-05173564f66aebceb3eb389bc5ff6c0b398d6f4e9959a14f
ToppCelldroplet-Tongue-Unstain-18m-Myeloid-Langerhans_cell|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P2RX2 NFAM1 WDFY4 ITGB7

6.78e-051745649019011eb8d9b7a95804fc11434f0fd42418103a
ToppCelldroplet-Tongue-Unstain-18m-Myeloid-Langerhans_cell|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P2RX2 NFAM1 WDFY4 ITGB7

6.78e-05174564deafbd0c2523afe09cc42f8c7b33945f3f5c00b4
ToppCelldroplet-Tongue-Unstain-18m-Myeloid|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P2RX2 NFAM1 WDFY4 ITGB7

6.78e-05174564f2eb0199f59e1e2f46da344c05289876bd254fa3
ToppCelldroplet-Tongue-nan-3m-Myeloid|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P2RX2 ADGRE1 NFAM1 ITGB7

7.25e-05177564b6c0ab701d9db3f19605b4d23f7e40adca3324e1
ToppCelldroplet-Tongue-nan-3m-Myeloid-Langerhans_cell|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P2RX2 ADGRE1 NFAM1 ITGB7

7.25e-0517756434bd46704827c9db7053bbd0c671dd0b661b79b4
ToppCelldroplet-Tongue-nan-3m-Myeloid-Langerhans_cell|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P2RX2 ADGRE1 NFAM1 ITGB7

7.25e-051775648f4b2f21091d981c12000489054198127098f62c
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FOXP2 CECR2 ARHGAP44 COBL

7.57e-0517956404ce3673e46606f63d9c87bcba3a64c96817d812
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-T_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IRS4 IL2RG ITGB7 CRTC2

7.74e-051805648cef63866c205df3825df84ce51fa61aa04ae491
ToppCelldroplet-Pancreas-Endocrine-21m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRE1 IL2RG WDFY4 ITGB7

8.07e-05182564cf32603ad9b9882b0bb873327d58b50dd26a5bd3
ToppCelldroplet-Pancreas-Endocrine-21m-Hematologic|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRE1 IL2RG WDFY4 ITGB7

8.07e-0518256471cfd0b6d464e3e1b1cca34f423abdf699cda48a
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_SCP_(0)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

MYT1 SCN9A ALK CCDC188

8.25e-05183564f517215ff45dec914af52dfdbc4579c19654c3aa
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FOXP2 CECR2 ARHGAP44 COBL

8.42e-0518456442ce855b4f8475a8298192feec785bdc69bc5bb0
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ARHGAP44 COBL PARD3B SAMD4A

8.42e-0518456457c792e6e2fedba25d3350ffe649fd74750b579d
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FOXP2 CECR2 ARHGAP44 COBL

8.42e-05184564cdf6f1c6cce97a7effa0c55959652e2c0b6992b3
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ARHGAP44 COBL PARD3B SAMD4A

8.42e-05184564d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D175|Adult / Lineage, Cell type, age group and donor

ARHGAP44 COBL PARD3B SAMD4A

8.60e-0518556432b4e68e551d435a732f253f6ad83408c759a642
ToppCelldroplet-Bladder-BLADDER-1m-Hematologic-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFAM1 IL2RG DSN1 ITGB7

8.60e-05185564969248b63d4ce335f223528de756bcddffadbd77
ToppCellPBMC-Severe-Myeloid-pDC-pDC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SCN9A COBL WDFY4 NOTCH4

8.78e-0518656431df1eafa3010bc1be6fc4d4689f1393d69b6b13
ToppCellsystemic_lupus_erythematosus-flare-Myeloid-plasmacytoid_dendritic_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

P2RX2 SCN9A COBL NOTCH4

8.78e-05186564a07694caf7fede06a47636725bcc7f09909cdf07
ToppCellPBMC-Severe-Myeloid-pDC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SCN9A COBL WDFY4 NOTCH4

8.78e-05186564eaa431ccd4cdd36fe06a44987603ec9979025aa8
ToppCellMultiple_Sclerosis-Myeloid-pDC|Multiple_Sclerosis / Disease, Lineage and Cell Type

SCN9A COBL WDFY4 NOTCH4

8.78e-05186564330a4f669adea91ff9f2dff2de2210f5e3401e19
ToppCellPBMC-Severe-Myeloid-pDC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

SCN9A COBL WDFY4 NOTCH4

8.78e-05186564b95be984e308d4f9061274a35995ec558d434e74
ToppCellPBMC-Severe-Myeloid-pDC-pDC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SCN9A COBL WDFY4 NOTCH4

8.78e-051865648f7949740286f64e034d1eb533ebc2c6f71ae966
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FOXP2 CECR2 ARHGAP44 COBL

8.78e-051865644e94158db52df41d71e67b02b9895a358eebee0f
ToppCellPBMC-Severe-Myeloid-pDC-pDC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

SCN9A COBL WDFY4 NOTCH4

8.78e-0518656495c7318e521fb6aa02e244b1e81e6b2a62107756
ToppCellhealthy_donor-Lymphocytic-Dendritic|healthy_donor / Disease condition, Lineage, Cell class and subclass

SCN9A COBL WDFY4 NOTCH4

8.78e-05186564916f2aeea4989ba7a29e071e348a51010f010223
ToppCellPBMC-Severe-Myeloid-pDC-pDC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SCN9A COBL WDFY4 NOTCH4

8.78e-05186564b70cd94c651b56dcf2e55554533a5f1130845390
ToppCellCOVID-19_Severe-Myeloid-pDC|COVID-19_Severe / Disease group, lineage and cell class

SCN9A COBL WDFY4 NOTCH4

8.78e-051865643db5ed69d49e5d79f990aca0295ddce4c297a05c
ToppCellhealthy_donor-Lymphocytic-Dendritic-pDC|healthy_donor / Disease condition, Lineage, Cell class and subclass

SCN9A COBL WDFY4 NOTCH4

8.78e-0518656445f66619e45d590c7365a51782d4ac46b7d31fde
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

NCOA2 HMCN1 ARID2 PARD3B

8.78e-0518656403db813598b67b1e08f759758a1c2023396921fa
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FOXP2 CECR2 ARHGAP44 COBL

8.96e-0518756458d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC44A5 FOXP2 MYT1 COBL

8.96e-05187564c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1|Adult / Lineage, Cell type, age group and donor

ARHGAP44 COBL PARD3B SAMD4A

8.96e-0518756477f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCellcontrol-pDC|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SCN9A COBL WDFY4 NOTCH4

8.96e-05187564c78aee98b32719aa45811b620fc97be1ecf5fd53
ToppCellPBMC-Mild-Myeloid-pDC-pDC|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

SCN9A COBL WDFY4 NOTCH4

9.15e-0518856489411c4db3df5e1dc36cf8af4ffcc0abbecbe4df
ToppCellsystemic_lupus_erythematosus-flare-Myeloid-plasmacytoid_dendritic_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

P2RX2 SCN9A COBL NOTCH4

9.15e-0518856426405ef1b934744e672c642db78834c21d3ba28f
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC44A5 FOXP2 COBL SAMD4A

9.15e-05188564af740fa78542438fdff627ea1f74f4eee43316be
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

COL16A1 GLI1 ZNF423 NOTCH4

9.15e-05188564c90669b51e1902fe7726555290c91c92a911df83
ToppCellPBMC-Mild-Myeloid-pDC|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

SCN9A COBL WDFY4 NOTCH4

9.15e-05188564de6a270b6e4fe09c39a52c296632d86ada98465b
ToppCellCOVID-19_Severe-pDC|World / disease group, cell group and cell class

SCN9A COBL WDFY4 NOTCH4

9.15e-051885644c8e328b8206120708b05ea3c5865a0200dc5c4e
ToppCellPBMC-Mild-Myeloid-pDC-pDC-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SCN9A COBL WDFY4 NOTCH4

9.15e-05188564879054b780378ae05be68e597c77c931bf0ade03
ToppCellPBMC-Mild-Myeloid-pDC|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SCN9A COBL WDFY4 NOTCH4

9.34e-05189564209cae68d78c8f72479b169e27c3ff7e143adece
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FOXP2 COBL NFKBIZ SAMD4A

9.34e-05189564aadb7a2de4cbe7f0958651f2739bba430b93f5c1
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

NCOA2 ARID1B FOXP2 PARD3B

9.34e-05189564830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCellPBMC-Mild-Myeloid-pDC-pDC-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SCN9A COBL WDFY4 NOTCH4

9.34e-05189564a9ad1fb12304541f909dd0eeac9b9eb28c31fd41
ToppCellCOVID-19_Mild-Myeloid-pDC|COVID-19_Mild / Disease group, lineage and cell class

SCN9A COBL WDFY4 NOTCH4

9.34e-05189564c6cfd6aa21c19f2c62d80218bbc924e14e82aada
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FOXP2 COBL NFKBIZ SAMD4A

9.34e-051895648977f3295b7df7c7474b3f371de90a82ae4bb50c
ToppCellControl-Myeloid-pDC|Control / Disease group, lineage and cell class

SCN9A COBL WDFY4 NOTCH4

9.34e-0518956446770b99da42f11f10cfc67cea8562342d60b867
ToppCellPBMC-Mild-Myeloid-pDC-pDC|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SCN9A COBL WDFY4 NOTCH4

9.34e-0518956498ca646231fbd5f29827c2dd31ac4503026bad7d
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC44A5 FOXP2 MYT1 COBL

9.53e-051905641cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC44A5 FOXP2 MYT1 COBL

9.53e-0519056459bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCell3'_v3-bone_marrow-Myeloid_Dendritic-pDC|bone_marrow / Manually curated celltypes from each tissue

SCN9A COBL WDFY4 NOTCH4

9.53e-05190564dde0e34f6a06cdbbb65c86472360c09f0279a572
ToppCellBLOOD--(3)_MNP-(3)_DC_(cDC+pDC)|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

SCN9A IL2RG WDFY4 ITGB7

9.53e-051905649b8de47f7a2e6137d934ccce32417ab15eb54f46
ToppCellCOVID-19_Severe-pDC|COVID-19_Severe / disease group, cell group and cell class

SCN9A COBL WDFY4 NOTCH4

9.53e-05190564c5ab6b7492fb86aff3d2af3eb671c9f985ae4aeb
ToppCellBac-SEP-Lymphocyte-T_NK-gdT|Bac-SEP / Disease, Lineage and Cell Type

ZFR2 PBX4 IL2RG ITGB7

9.53e-05190564c7c5bc50082b2243cae8eb04784d03f14a739b3b
ToppCellCOVID-19_Moderate-pDC|World / disease group, cell group and cell class

SCN9A COBL WDFY4 NOTCH4

9.73e-0519156493adfbc0b22f6006d6d5ad67a99e33cbe9e1dfe9
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC44A5 FOXP2 COBL PARD3B

9.73e-05191564d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellCOVID-19_Moderate-pDC|COVID-19_Moderate / disease group, cell group and cell class

SCN9A COBL WDFY4 NOTCH4

9.73e-051915649d0ffa65c547e20b4076fd97776d7738cbd453ec
ToppCellChildren_(3_yrs)-Epithelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

FOXP2 CECR2 ARHGAP44 COBL

9.73e-05191564e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCellEpithelial|World / Lineage, Cell type, age group and donor

FOXP2 CECR2 ARHGAP44 COBL

9.92e-05192564499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

FOXP2 ARHGAP44 COBL PARD3B

9.92e-05192564efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCellVE-pDC-|VE / Condition, Cell_class and T cell subcluster

SCN9A COBL WDFY4 NOTCH4

1.01e-04193564583724de588fcde3aeda056138c522dc0225a387
ToppCellcontrol-pDC|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SCN9A COBL WDFY4 NOTCH4

1.01e-0419356430a6559c9a9e8941861cb259b4836acccc427e68
ToppCellVE-pDC|VE / Condition, Cell_class and T cell subcluster

SCN9A COBL WDFY4 NOTCH4

1.01e-04193564bb759dc9ef0ec41d655002f59021d62d62d44289
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC44A5 FOXP2 COBL SAMD4A

1.03e-04194564e577d9e88390b36b5a09b97fe1026089892275a3
ToppCellnucseq-Epithelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FOXP2 ARHGAP44 COBL PARD3B

1.05e-041955649406866f99555198a9be311fbd65751b70f35446
ToppCellfacs-Lung-3m|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARID1B COL16A1 ARHGAP44 LAMB2

1.05e-04195564c4648c0332c3826776f9ad3f5f803dbac2b4c0c0
DiseasePAROXYSMAL EXTREME PAIN DISORDER

SCN9A SCN10A

9.85e-063542C1833661
DiseasePrimary Erythermalgia

SCN9A SCN10A

9.85e-063542C0014805
DiseaseHereditary Sensory Autonomic Neuropathy, Type 5

SCN9A SCN10A

6.86e-057542C0020075
DiseaseCongenital Pain Insensitivity

SCN9A SCN10A

6.86e-057542C0002768
Diseasehemangiopericytoma (is_marker_for)

EPHB4 NOTCH4

1.17e-049542DOID:264 (is_marker_for)
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN9A SCN10A

1.47e-0410542DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN9A SCN10A

1.47e-0410542DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN9A SCN10A

2.14e-0412542DOID:0060170 (implicated_via_orthology)
DiseaseCoffin-Siris syndrome

ARID1B ARID2

2.53e-0413542C0265338
DiseaseT wave morphology measurement

SCN10A KCNQ1

2.95e-0414542EFO_0008398
DiseaseNeuralgia, Supraorbital

SCN9A SCN10A

3.88e-0416542C0038870
DiseaseNeuralgia, Iliohypogastric Nerve

SCN9A SCN10A

3.88e-0416542C0423712
DiseaseNeuralgia, Perineal

SCN9A SCN10A

3.88e-0416542C0423711
DiseaseNeuralgia

SCN9A SCN10A

3.88e-0416542C0027796
DiseaseRomano-Ward Syndrome

SCN10A KCNQ1

3.88e-0416542C0035828
DiseaseNeuralgia, Atypical

SCN9A SCN10A

3.88e-0416542C0234247
DiseaseNeuralgia, Stump

SCN9A SCN10A

3.88e-0416542C0234249
DiseaseParoxysmal Nerve Pain

SCN9A SCN10A

3.88e-0416542C0751373
DiseaseNerve Pain

SCN9A SCN10A

3.88e-0416542C0751372
DiseaseNeuralgia, Ilioinguinal

SCN9A SCN10A

3.88e-0416542C0751371
DiseaseNeuralgia, Vidian

SCN9A SCN10A

3.88e-0416542C0042656
DiseaseQT interval

NCOA2 ARID2 SCN10A KCNQ1 LAMB2 NOTCH4

4.23e-04534546EFO_0004682
DiseaseHereditary Non-Polyposis Colon Cancer Type 2

NFKBIZ FAN1

5.51e-0419542C1333991
DiseaseColorectal cancer, hereditary nonpolyposis, type 1

NFKBIZ FAN1

5.51e-0419542C2936783
DiseaseNeurodevelopmental Disorders

ARID1B KMT2A PARD3B

6.69e-0493543C1535926
DiseaseHereditary Nonpolyposis Colorectal Neoplasms

NFKBIZ FAN1

1.04e-0326542C0009405
DiseaseEpilepsy

ARID1B P2RX2 SCN9A

1.06e-03109543C0014544
DiseaseHereditary non-polyposis colorectal cancer syndrome

NFKBIZ FAN1

1.12e-0327542C1112155
Diseasecytotoxicity measurement, response to clozapine

HMCN1 MYT1

1.29e-0329542EFO_0006952, GO_0097338
DiseaseHereditary Nonpolyposis Colorectal Cancer

NFKBIZ FAN1

1.29e-0329542C1333990
Diseasecancer (implicated_via_orthology)

ARID1B ALK ITGB7 NOTCH4

1.47e-03268544DOID:162 (implicated_via_orthology)
Diseasejoint hypermobility measurement

ARHGAP44 NOTCH4

1.67e-0333542EFO_0007905

Protein segments in the cluster

PeptideGeneStartEntry
SCENPGVPRHGSQNN

CSMD3

3351

Q7Z407
ATFGHGANTGAQCPP

COL16A1

16

Q07092
GGPPQSSVVQNHSTG

ARID2

736

Q68CP9
AGPCFDQHGGQQSPG

ARID1B

331

Q8NFD5
CTAGQSHPDGSPQQG

ANKS1A

521

Q92625
ASEPQTRHGSQGPGQ

CECR2

226

Q9BXF3
HSGQGALNCESAPQG

PARD3B

806

Q8TEW8
AHITQPCGSGGSVDP

KCNQ1

636

P51787
PQSSPAEQCQDFHGG

NFKBIZ

246

Q9BYH8
GEGSCQPCPANSHSN

EPHB4

281

P54760
PGGLTVNNCQPAGHV

KRT39

36

Q6A163
ACGPHQAAGPDLGSS

L3MBTL1

171

Q9Y468
ALSGPHPQSGGQDND

FAM205A

406

Q6ZU69
ALSGPHPQSGGQDND

FAM205BP

136

Q63HN1
HIDSNGNSSPGCSPQ

FOXP2

651

O15409
NPQGSLSSECNPHGG

LAMB2

786

P55268
GTEGLSGPPFCHQAN

GLI1

31

P08151
PEAHSQEQGHPQTGC

GAGE2A

71

Q6NT46
NNPSTNGVNGHLPGD

MED4

191

Q9NPJ6
DPGSSQSPGQCGDNT

LRRC66

481

Q68CR7
PSVQHGGRPCEGNAV

HMCN1

4616

Q96RW7
TQPQAPHCSDGQGHL

ITGB7

481

P26010
SPPSGQEGQQGAECG

P2RX2

416

Q9UBL9
ATPGGCPNDNSIEHS

PBX4

111

Q9BYU1
SVQSSGGQPPGRQSH

CRTC2

516

Q53ET0
PASSSHGGGLDQPCQ

CCDC188

21

H7C350
GSGSHCSPDGAPQVL

COBL

371

O75128
LQNPPAIHGSGSGSC

DSN1

341

Q9H410
ALGEGPGASPCNQHS

IL2RG

341

P31785
SPPCGSVEQGHGNNQ

KMT2A

3006

Q03164
CQGSSCQPVSGEGQP

KRTAP29-1

186

A8MX34
PTDSQGHFCGQKGTP

SLC44A5

71

Q8NCS7
PAQSDPGQCPDQSHG

CCDC174

416

Q6PII3
GTDSFNGHPPQGCAS

POLR3E

541

Q9NVU0
VAGGSNPGAHNPSAN

IRS4

1181

O14654
PLEQGSSCNGPGQTT

FAN1

356

Q9Y2M0
PTNCHPGLGTENQSH

NFAM1

96

Q8NET5
PEAHSQEQGHPQTGC

GAGE2B

71

Q13066
HPGSSVEGDCGNPSV

SCN9A

1721

Q15858
QGPPHCRNGGTCQNS

NOTCH4

321

Q99466
TACAGTQPGAQPGAQ

ARHGAP44

611

Q17R89
SQSCQEGGGHDLLPP

SPATC1L

36

Q9H0A9
QPGPQAQCSSGGRTH

TRIOBP

1286

Q9H2D6
TTCGASGPHGPTQAQ

ALK

686

Q9UM73
HPNPEGSQKDGNFSC

ADGRE1

301

Q14246
NSPAHQALCSGNPGQ

NCOA2

401

Q15596
PDGASCQGQPALHSE

USP42

676

Q9H9J4
GDSGCHNPLSESPQG

TEX13D

326

A0A0J9YY54
ADSGQPGTQEACGQP

ZFR2

121

Q9UPR6
PGTQEACGQPSPHGS

ZFR2

126

Q9UPR6
HLGGNPDQCSEPGGN

ZSCAN20

816

P17040
NLPNSNGTRGDCGSP

SCN10A

1681

Q9Y5Y9
PVNHGPQEESCGSSQ

RIPK2

336

O43353
THRGNPGCSGSQTAQ

WDFY4

946

Q6ZS81
GNLVNGTCSPDSGHP

SGSM1

756

Q2NKQ1
TGSPGKQPGENSDCH

ZNF8

221

P17098
VSHCGPNANPSDGNN

ZNF423

501

Q2M1K9
HGAAFPPGSSCGQQQ

ZNF584

136

Q8IVC4
PPGSSCGQQQEVHVA

ZNF584

141

Q8IVC4
GASGGLQPHQLSSCD

SAMD4A

466

Q9UPU9
CPTPGCTGQGHVNSN

MYT1

486

Q01538