Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	5'-deoxyribose-5-phosphate lyase activity	HMGA2 POLG	5.28e-05	8	28	2	GO:0051575
GeneOntologyMolecularFunction	chondroitin sulfate binding	ADGRE5 ADGRE2	1.03e-04	11	28	2	GO:0035374
Domain	GPCR_2_CD97	ADGRE5 ADGRE2	2.17e-06	2	28	2	IPR003056
Domain	CXorf40	EOLA2 EOLA1	2.17e-06	2	28	2	IPR033615
Domain	ASCH_domain	EOLA2 EOLA1	6.50e-06	3	28	2	IPR007374
Domain	ASCH	EOLA2 EOLA1	6.50e-06	3	28	2	SM01022
Domain	AT_hook	HMGA2 CECR2	2.57e-04	16	28	2	PF02178
Domain	EGF_CA	ADGRE5 HMCN2 ADGRE2	2.84e-04	86	28	3	PF07645
Domain	PUA-like_domain	EOLA2 EOLA1	3.65e-04	19	28	2	IPR015947
Domain	EGF_Ca-bd_CS	ADGRE5 HMCN2 ADGRE2	4.05e-04	97	28	3	IPR018097
Domain	EGF_CA	ADGRE5 HMCN2 ADGRE2	4.30e-04	99	28	3	PS01187
Domain	ASX_HYDROXYL	ADGRE5 HMCN2 ADGRE2	4.43e-04	100	28	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	ADGRE5 HMCN2 ADGRE2	5.25e-04	106	28	3	IPR000152
Domain	EGF_CA	ADGRE5 HMCN2 ADGRE2	7.91e-04	122	28	3	SM00179
Domain	EGF-like_Ca-bd_dom	ADGRE5 HMCN2 ADGRE2	8.29e-04	124	28	3	IPR001881
Domain	HMGI/Y_DNA-bd_CS	HMGA2 CECR2	9.81e-04	31	28	2	IPR000637
Domain	GPS	ADGRE5 ADGRE2	1.18e-03	34	28	2	SM00303
Domain	GPCR_2_secretin-like_CS	ADGRE5 ADGRE2	1.18e-03	34	28	2	IPR017983
Domain	GPS	ADGRE5 ADGRE2	1.25e-03	35	28	2	PF01825
Domain	GPS	ADGRE5 ADGRE2	1.32e-03	36	28	2	PS50221
Domain	GPS	ADGRE5 ADGRE2	1.40e-03	37	28	2	IPR000203
Domain	Growth_fac_rcpt_	ADGRE5 HMCN2 ADGRE2	1.61e-03	156	28	3	IPR009030
Domain	G_PROTEIN_RECEP_F2_2	ADGRE5 ADGRE2	2.54e-03	50	28	2	PS00650
Domain	7tm_2	ADGRE5 ADGRE2	2.54e-03	50	28	2	PF00002
Domain	GPCR_2-like	ADGRE5 ADGRE2	3.64e-03	60	28	2	IPR017981
Domain	GPCR_2_secretin-like	ADGRE5 ADGRE2	3.64e-03	60	28	2	IPR000832
Domain	G_PROTEIN_RECEP_F2_4	ADGRE5 ADGRE2	3.76e-03	61	28	2	PS50261
Domain	EGF_3	ADGRE5 HMCN2 ADGRE2	5.11e-03	235	28	3	PS50026
Domain	EGF-like_dom	ADGRE5 HMCN2 ADGRE2	6.00e-03	249	28	3	IPR000742
Domain	ARM-type_fold	ARFGEF3 HEATR4 HEATR9	1.39e-02	339	28	3	IPR016024
Pathway	WP_GPCRS_CLASS_B_SECRETINLIKE	ADGRE5 ADGRE2	2.88e-04	24	15	2	MM15992
Pathway	WP_GPCRS_CLASS_B_SECRETINLIKE	ADGRE5 ADGRE2	2.88e-04	24	15	2	M39643
Pubmed	The role of the RGD motif in CD97/ADGRE5-and EMR2/ADGRE2-modulated tumor angiogenesis.	ADGRE5 ADGRE2	7.69e-07	2	31	2	31594642
Pubmed	Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration.	ADGRE5 ADGRE2	7.69e-07	2	31	2	18941248
Pubmed	Mice overexpressing CD97 in intestinal epithelial cells provide a unique model for mammalian postnatal intestinal cylindrical growth.	ADGRE5 ADGRE2	7.69e-07	2	31	2	23676664
Pubmed	The epidermal growth factor-seven transmembrane (EGF-TM7) receptor CD97 is required for neutrophil migration and host defense.	ADGRE5 ADGRE2	7.69e-07	2	31	2	14707087
Pubmed	Overexpression of CD97 in intestinal epithelial cells of transgenic mice attenuates colitis by strengthening adherens junctions.	ADGRE5 ADGRE2	7.69e-07	2	31	2	20084281
Pubmed	Differential role of CD97 in interleukin-8-induced and granulocyte-colony stimulating factor-induced hematopoietic stem and progenitor cell mobilization.	ADGRE5 ADGRE2	7.69e-07	2	31	2	18326527
Pubmed	Skeletal muscle expression of the adhesion-GPCR CD97: CD97 deletion induces an abnormal structure of the sarcoplasmatic reticulum but does not impair skeletal muscle function.	ADGRE5 ADGRE2	7.69e-07	2	31	2	24949957
Pubmed	Molecular cloning and characterization of mouse CD97.	ADGRE5 ADGRE2	7.69e-07	2	31	2	10744645
Pubmed	Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease.	ADGRE5 ADGRE2	7.69e-07	2	31	2	20167235
Pubmed	The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans.	ADGRE5 ADGRE2	7.69e-07	2	31	2	12829604
Pubmed	CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD.	ADGRE5 ADGRE2	7.69e-07	2	31	2	34314469
Pubmed	Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells.	ADGRE5 ADGRE2	7.69e-07	2	31	2	15498814
Pubmed	Therapeutic antibody targeting of CD97 in experimental arthritis: the role of antigen expression, shedding, and internalization on the pharmacokinetics of anti-CD97 monoclonal antibody 1B2.	ADGRE5 ADGRE2	7.69e-07	2	31	2	19717518
Pubmed	G Protein-Coupling of Adhesion GPCRs ADGRE2/EMR2 and ADGRE5/CD97, and Activation of G Protein Signalling by an Anti-EMR2 Antibody.	ADGRE5 ADGRE2	7.69e-07	2	31	2	31969668
Pubmed	Putative alternative trans-splicing of leukocyte adhesion-GPCR pre-mRNAs generates functional chimeric receptors.	ADGRE5 ADGRE2	7.69e-07	2	31	2	18267122
Pubmed	Improved antibacterial host defense and altered peripheral granulocyte homeostasis in mice lacking the adhesion class G protein receptor CD97.	ADGRE5 ADGRE2	7.69e-07	2	31	2	17158902
Pubmed	Contradictory Role of CD97 in Basal and Tumor Necrosis Factor-Induced Osteoclastogenesis In Vivo.	ADGRE5 ADGRE2	7.69e-07	2	31	2	26663852
Pubmed	CD97 is differentially expressed on murine hematopoietic stem-and progenitor-cells.	ADGRE5 ADGRE2	7.69e-07	2	31	2	18603564
Pubmed	Structural characterization of mouse CD97 and study of its specific interaction with the murine decay-accelerating factor (DAF, CD55).	ADGRE5 ADGRE2	2.31e-06	3	31	2	10540231
Pubmed	How to Obtain a Mega-Intestine with Normal Morphology: In Silico Modelling of Postnatal Intestinal Growth in a Cd97-Transgenic Mouse.	ADGRE5 ADGRE2	2.31e-06	3	31	2	34298973
Pubmed	Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex.	ADGRE5 ADGRE2	2.31e-06	3	31	2	11297558
Pubmed	Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain.	ADGRE5 ADGRE2	2.31e-06	3	31	2	33497605
Pubmed	Deletion of either CD55 or CD97 ameliorates arthritis in mouse models.	ADGRE5 ADGRE2	2.31e-06	3	31	2	20131275
Pubmed	Platelets Promote Metastasis via Binding Tumor CD97 Leading to Bidirectional Signaling that Coordinates Transendothelial Migration.	ADGRE5 ADGRE2	2.31e-06	3	31	2	29669286
Pubmed	Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55.	ADGRE5 ADGRE2	2.31e-06	3	31	2	23447688
Pubmed	Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55.	ADGRE5 ADGRE2	2.31e-06	3	31	2	17449467
Pubmed	130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus.	EOLA2 EOLA1	4.61e-06	4	31	2	8717057
Pubmed	CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation.	ADGRE5 ADGRE2	4.61e-06	4	31	2	37978243
Pubmed	Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication.	ADGRE5 ADGRE2	1.15e-05	6	31	2	10501980
Pubmed	The EGF-TM7 family: a postgenomic view.	ADGRE5 ADGRE2	1.15e-05	6	31	2	14647991
Pubmed	A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense.	ADGRE5 ADGRE2	1.15e-05	6	31	2	21984892
Pubmed	CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells.	ADGRE5 ADGRE2	1.61e-05	7	31	2	35143305
Pubmed	Molecular and phenotypic variation in patients with severe Hunter syndrome.	EOLA2 EOLA1	1.61e-05	7	31	2	9147653
Pubmed	Common variants in the GDF5-UQCC region are associated with variation in human height.	HMGA2 POLG	1.61e-05	7	31	2	18193045
Pubmed	Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function.	ADGRE5 ADGRE2	2.15e-05	8	31	2	38049580
Pubmed	Complement factor H, a marker of self protects against experimental autoimmune encephalomyelitis.	ADGRE5 ADGRE2	6.95e-05	14	31	2	19299737
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	GREB1L KNDC1 CECR2	1.04e-04	102	31	3	11214970
Pubmed	International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.	ADGRE5 ADGRE2	3.99e-04	33	31	2	25713288
Pubmed	Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development.	TGIF1 HMGA2	4.49e-04	35	31	2	22991445
GeneFamily	CD molecules\|Adhesion G protein-coupled receptors, subfamily E	ADGRE5 ADGRE2	9.35e-06	5	18	2	915
ToppCell	facs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-23\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KNDC1 CABP2 HMGA2 FAM43B	2.96e-06	144	31	4	e9d62f202f0fa8747961036ef0eafed91fe8a42f
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 EMILIN3 CABP2 STXBP5L	8.33e-06	187	31	4	1b2fdbfb1ce3f19795dfc4b1da5a94f4b057ec41
Disease	adhesion G protein-coupled receptor E2 measurement	ADGRE5 ADGRE2	5.59e-06	4	29	2	EFO_0021892
Disease	melanoma	HMGA2 HMCN2	6.81e-03	126	29	2	EFO_0000756

Protein segments in the cluster

Peptide	Gene	Start	Entry
NPRWLLEPIPRKGGK	EOLA1	126	Q8TE69
NPRWLLEPIPRKGGK	EOLA2	126	Q96DE9
KRRRPKNYPPGPWRL	CYP2J2	36	P51589
RPGWKPRHGIPNNQK	ADGRE2	241	Q9UHX3
IKAHGLRPPWAPRLE	DNAH10OS	81	P0CZ25
RCRPGWKPRHGIPNN	ADGRE5	236	P48960
GKRPQRTKAELHPRW	CECR2	291	Q9BXF3
PGWVKPPGRKKRWGR	CCER1	131	Q8TC90
RPLPERHWLKDGRPL	HMCN2	911	Q8NDA2
PAQPRRWKAGPRERA	FAM43B	311	Q6ZT52
RPHLPGKKKIRWDPV	KLHDC10	51	Q6PID8
TRAPKHLWRQPRRPI	PDE4C	26	Q08493
KRPQHLPGHPGWYRK	POLG	561	P54098
KKRHRGWYPGSPLPQ	GREB1L	326	Q9C091
RVWKVPKPRRKPGRA	H1-7	121	Q75WM6
LGQKPAWGPARRRRH	MEIOSIN	141	C9JSJ3
PPRGKEKRQWRARMP	ARFGEF3	1871	Q5TH69
KRPRRPGASPNKWQS	HEATR4	221	Q86WZ0
TGEKRPRGRPRKWPQ	HMGA2	71	P52926
WRLPRGNGLVLPPHK	KNDC1	1416	Q76NI1
WRPRLRPGPHKALCA	EMILIN3	46	Q9NT22
KQHPGPLRPWRKRAA	FAM87A	21	P0C7U9
KRPWRRGPKDPLQWL	CABP2	6	Q9NPB3
AKSRGPWRRPPKKRH	SETD1B	1636	Q9UPS6
SKVNRWGPGRPPFRK	STXBP5L	776	Q9Y2K9
RLLDGIKQRPWKPGP	SH3RF1	71	Q7Z6J0
NLRKRGHPAPSPIWR	CLEC12B	26	Q2HXU8
KAGPRRPHRWELPRS	TGIF1	101	Q15583
SKPRKHRPQVIGPWQ	HEATR9	541	A2RTY3
HRPQVIGPWQPRIKK	HEATR9	546	A2RTY3
RRPHPLKPQDPSKGW	TTC31	491	Q49AM3
WLKPAVARLGPPRHR	ZNF669	16	Q96BR6