Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbenzodiazepine receptor binding

RIMBP3 RIMBP3B RIMBP3C

4.22e-095163GO:0030156
GeneOntologyBiologicalProcessneuromuscular synaptic transmission

RIMBP3 RIMBP3B RIMBP3C

2.69e-0636163GO:0007274
GeneOntologyCellularComponentmanchette

RIMBP3 RIMBP3B RIMBP3C

1.19e-0628163GO:0002177
MousePhenoectopic manchette

RIMBP3 RIMBP3B RIMBP3C

7.68e-0719143MP:0009377
MousePhenodetached sperm flagellum

RIMBP3 RIMBP3B RIMBP3C

1.05e-0621143MP:0008893
MousePhenodetached acrosome

RIMBP3 RIMBP3B RIMBP3C

1.03e-0544143MP:0009231
MousePhenoabnormal manchette morphology

RIMBP3 RIMBP3B RIMBP3C

1.11e-0545143MP:0009376
MousePhenokinked sperm flagellum

RIMBP3 RIMBP3B RIMBP3C

2.15e-0556143MP:0009237
MousePhenoabnormal sperm nucleus morphology

RIMBP3 RIMBP3B RIMBP3C

4.97e-0574143MP:0009232
MousePhenoabnormal spermatid morphology

RIMBP3 RIMBP3B RIMBP3C EWSR1

5.00e-05217144MP:0006380
MousePhenoabnormal motile cilium morphology

RIMBP3 RIMBP3B DYNC2H1 RIMBP3C

3.92e-04370144MP:0013206
MousePhenoabnormal acrosome morphology

RIMBP3 RIMBP3B RIMBP3C

4.79e-04159143MP:0008898
MousePhenoincreased mortality induced by gamma-irradiation

EWSR1 FUS

6.08e-0437142MP:0001658
MousePhenoabnormal cilium morphology

RIMBP3 RIMBP3B DYNC2H1 RIMBP3C

7.10e-04433144MP:0013202
MousePhenoimpaired fertilization

RIMBP3 RIMBP3B RIMBP3C

1.02e-03206143MP:0000242
MousePhenoincreased mortality induced by ionizing radiation

EWSR1 FUS

1.15e-0351142MP:0003992
MousePhenoabnormal fertilization

RIMBP3 RIMBP3B RIMBP3C

1.25e-03221143MP:0005410
MousePhenoabnormal mortality induced by ionizing radiation

EWSR1 FUS

1.34e-0355142MP:0020149
MousePhenoabnormal spermatogenesis

RIMBP3 RIMBP3B RIMBP3C EWSR1 FUS

1.41e-03910145MP:0001156
MousePhenoabnormal response to radiation

EWSR1 FUS

1.44e-0357142MP:0012734
MousePhenoabnormal spermiogenesis

RIMBP3 RIMBP3B RIMBP3C

1.53e-03237143MP:0001932
MousePhenomale infertility

RIMBP3 RIMBP3B RIMBP3C EWSR1 FUS

1.66e-03944145MP:0001925
MousePhenoabnormal sperm head morphology

RIMBP3 RIMBP3B RIMBP3C

2.01e-03261143MP:0009230
MousePhenoabnormal sperm flagellum morphology

RIMBP3 RIMBP3B RIMBP3C

2.85e-03295143MP:0008892
MousePhenoabnormal gametogenesis

RIMBP3 RIMBP3B RIMBP3C EWSR1 FUS

2.90e-031070145MP:0001929
DomainFN3

RIMBP3 RIMBP3B DSCAML1 RIMBP3C

2.06e-05199164PS50853
DomainFN3_dom

RIMBP3 RIMBP3B DSCAML1 RIMBP3C

2.50e-05209164IPR003961
Domain-

EWSR1 FUS

3.08e-05101624.10.1060.10
DomainSH3_9

RIMBP3 RIMBP3B RIMBP3C

3.77e-0578163PF14604
DomainSH3_2

RIMBP3 RIMBP3B RIMBP3C

5.05e-0586163IPR011511
DomainSH3_2

RIMBP3 RIMBP3B RIMBP3C

5.05e-0586163PF07653
Domainzf-RanBP

EWSR1 FUS

1.57e-0422162PF00641
DomainZnF_RBZ

EWSR1 FUS

1.72e-0423162SM00547
DomainZF_RANBP2_2

EWSR1 FUS

1.72e-0423162PS50199
DomainZF_RANBP2_1

EWSR1 FUS

1.88e-0424162PS01358
DomainZnf_RanBP2

EWSR1 FUS

2.04e-0425162IPR001876
DomainFN3

RIMBP3B DSCAML1 RIMBP3C

4.87e-04185163SM00060
DomainSH3

RIMBP3 RIMBP3B RIMBP3C

7.64e-04216163PS50002
DomainSH3

RIMBP3 RIMBP3B RIMBP3C

7.64e-04216163SM00326
DomainSH3_domain

RIMBP3 RIMBP3B RIMBP3C

8.06e-04220163IPR001452
Domain-

RIMBP3 RIMBP3B DSCAML1 RIMBP3C

2.04e-036631642.60.40.10
DomainIg-like_fold

RIMBP3 RIMBP3B DSCAML1 RIMBP3C

2.56e-03706164IPR013783
Pubmed

RIM-BP3 is a manchette-associated protein essential for spermiogenesis.

RIMBP3 RIMBP3B RIMBP3C

3.19e-10416319091768
Pubmed

Structure and evolution of RIM-BP genes: identification of a novel family member.

RIMBP3 RIMBP3B RIMBP3C

7.98e-10516317855024
Pubmed

Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.

RIMBP3 RIMBP3B RIMBP3C

2.90e-081416317662146
Pubmed

EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions.

EWSR1 FUS

1.98e-07216226573619
Pubmed

A morphologic and molecular reappraisal of myoepithelial tumors of soft tissue, bone, and viscera with EWSR1 and FUS gene rearrangements.

EWSR1 FUS

1.98e-07216231994243
Pubmed

Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS.

EWSR1 FUS

1.98e-0721628921363
Pubmed

Novel FUS-KLF17 and EWSR1-KLF17 fusions in myoepithelial tumors.

EWSR1 FUS

5.95e-07316225706482
Pubmed

mRNA and protein levels of FUS, EWSR1, and TAF15 are upregulated in liposarcoma.

EWSR1 FUS

5.95e-07316221344536
Pubmed

FUS-NFATC2 or EWSR1-NFATC2 Fusions Are Present in a Large Proportion of Simple Bone Cysts.

EWSR1 FUS

5.95e-07316232991339
Pubmed

Ewing sarcoma with ERG gene rearrangements: A molecular study focusing on the prevalence of FUS-ERG and common pitfalls in detecting EWSR1-ERG fusions by FISH.

EWSR1 FUS

5.95e-07316226690869
Pubmed

Characterization of a new brain-specific isoform of the EWS oncoprotein.

EWSR1 FUS

5.95e-07316211422378
Pubmed

Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions.

EWSR1 FUS

5.95e-07316238168093
Pubmed

Cytokeratin-positive Malignant Tumor in the Abdomen With EWSR1/FUS-CREB Fusion: A Clinicopathologic Study of 8 Cases.

EWSR1 FUS

5.95e-07316234049318
Pubmed

The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response.

EWSR1 FUS

5.95e-07316218620564
Pubmed

O-GlcNAc glycosylation stoichiometry of the FET protein family: only EWS is glycosylated with a high stoichiometry.

EWSR1 FUS

5.95e-07316227903134
Pubmed

A conserved N-terminal motif is required for complex formation between FUS, EWSR1, TAF15 and their oncogenic fusion proteins.

EWSR1 FUS

5.95e-07316223975937
Pubmed

A Subset of Malignant Mesotheliomas in Young Adults Are Associated With Recurrent EWSR1/FUS-ATF1 Fusions.

EWSR1 FUS

5.95e-07316228505004
Pubmed

Gene expression responses to FUS, EWS, and TAF15 reduction and stress granule sequestration analyses identifies FET-protein non-redundant functions.

EWSR1 FUS

5.95e-07316223049996
Pubmed

Aggregation of FET Proteins as a Pathological Change in Amyotrophic Lateral Sclerosis.

EWSR1 FUS

5.95e-07316227311318
Pubmed

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.

EWSR1 FUS

5.95e-07316221856723
Pubmed

Unclassified low grade spindle cell sarcoma with storiform pattern characterized by recurrent novel EWSR1/FUS-NACC1 fusions.

EWSR1 FUS

5.95e-07316233859361
Pubmed

Role of FET proteins in neurodegenerative disorders.

EWSR1 FUS

5.95e-07316227415968
Pubmed

Post-transcriptional regulation of FUS and EWS protein expression by miR-141 during neural differentiation.

EWSR1 FUS

1.19e-06416228453628
Pubmed

The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.

EWSR1 FUS

1.19e-0641629660765
Pubmed

Characterization of TFG in mus musculus and Caenorhabditis elegans.

EWSR1 FUS

1.19e-06416210092511
Pubmed

The neurodegenerative diseases ALS and SMA are linked at the molecular level via the ASC-1 complex.

EWSR1 FUS

1.19e-06416230398641
Pubmed

IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.

EWSR1 FUS

1.98e-06516218648544
Pubmed

Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription.

EWSR1 FUS

2.97e-06616218509338
Pubmed

The hnRNP RALY regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization.

EWSR1 FUS

2.97e-06616230354839
Pubmed

TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.

EWSR1 FUS

8.91e-061016218632687
Pubmed

Characterization of ubiquitination dependent dynamics in growth factor receptor signaling by quantitative proteomics.

EWSR1 FUS

8.91e-061016221956701
Pubmed

PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805.

DERL1 EWSR1 FUS

1.08e-059516336300783
Pubmed

FET family fusion oncoproteins target the SWI/SNF chromatin remodeling complex.

EWSR1 FUS

4.99e-052316230962207
Pubmed

Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.

EWSR1 FUS

4.99e-052316218320585
Pubmed

Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.

EWSR1 FUS

8.57e-053016215782174
Pubmed

Proline-rich sequence recognition: II. Proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactions.

TRIM47 EWSR1

9.76e-053216219542561
Pubmed

A functional reference map of the RNF8 interactome in cancer.

EWSR1 FUS FLG2

1.28e-0421816335831895
Pubmed

GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.

EWSR1 FUS FLG2

1.37e-0422316333731348
Pubmed

ZF21 is a new regulator of focal adhesion disassembly and a potential member of the spreading initiation center.

EWSR1 FUS

2.03e-044616220890123
Pubmed

Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop.

EWSR1 FUS FLG2

2.15e-0426016336199071
Pubmed

The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome.

EWSR1 FUS

2.50e-045116226269332
Pubmed

The nuclear transcription factor RARalpha associates with neuronal RNA granules and suppresses translation.

EWSR1 FUS

2.80e-045416218495661
Pubmed

A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.

EWSR1 FUS FLG2

2.85e-0428616332041737
Pubmed

Ring finger protein 12 activates AKT signalling to promote the progression of liver cancer by interacting with EGFR.

EWSR1 FUS FLG2

2.93e-0428916337132043
Pubmed

Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN).

FUS FLG2

4.06e-046516232120844
Pubmed

SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.

EWSR1 FLG2

4.18e-046616236095012
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

MUC19 DYNC2H1 EWSR1 FUS

4.19e-0480716430575818
Pubmed

Interaction between the scaffold proteins CBP by IQGAP1 provides an interface between gene expression and cytoskeletal activity.

EWSR1 FUS

4.57e-046916232238831
InteractionKLHL5 interactions

KLHL5 FUS

7.86e-0518152int:KLHL5
InteractionANXA6 interactions

ADAM8 EWSR1 ARHGAP24

9.11e-05121153int:ANXA6
InteractionFBP1 interactions

TRIM47 EWSR1 FUS FLG2

1.03e-04348154int:FBP1
InteractionRNU1-1 interactions

EWSR1 FUS

1.08e-0421152int:RNU1-1
InteractionHRNR interactions

EWSR1 ARHGAP24 FLG2

1.21e-04133153int:HRNR
InteractionPPIL1 interactions

RIMBP3 EWSR1 FUS

1.62e-04147153int:PPIL1
InteractionSPAG7 interactions

DYNC2H1 EWSR1

2.37e-0431152int:SPAG7
InteractionKLHL4 interactions

MUC19 KLHL5

2.69e-0433152int:KLHL4
InteractionNKD2 interactions

EWSR1 FUS

3.97e-0440152int:NKD2
InteractionUSP20 interactions

DERL1 PBX4 FLG2

4.37e-04206153int:USP20
InteractionHERPUD1 interactions

DERL1 EWSR1

5.48e-0447152int:HERPUD1
InteractionDDX20 interactions

DYNC2H1 EWSR1 FUS

5.59e-04224153int:DDX20
InteractionNONO interactions

DYNC2H1 EWSR1 ARHGAP24 FUS

5.85e-04549154int:NONO
InteractionACAT1 interactions

EWSR1 ARHGAP24 FUS

6.19e-04232153int:ACAT1
InteractionDDX5 interactions

DERL1 EWSR1 ARHGAP24 FUS

6.65e-04568154int:DDX5
InteractionARHGAP25 interactions

DYNC2H1 ARHGAP24

6.71e-0452152int:ARHGAP25
InteractionUFL1 interactions

DERL1 EWSR1 ARHGAP24 FUS FLG2

6.78e-041031155int:UFL1
InteractionCUL2 interactions

EWSR1 ARHGAP24 FUS FLG2

7.72e-04591154int:CUL2
InteractionCKAP4 interactions

DERL1 EWSR1 ARHGAP24 FUS

7.77e-04592154int:CKAP4
InteractionUCHL1 interactions

DERL1 FUS FLG2

7.96e-04253153int:UCHL1
InteractionMLX interactions

DERL1 EWSR1

9.53e-0462152int:MLX
InteractionFLI1 interactions

EWSR1 FUS

9.53e-0462152int:FLI1
InteractionNOXA1 interactions

RIMBP3 RIMBP3C

9.84e-0463152int:NOXA1
InteractionDCUN1D1 interactions

EWSR1 FUS FLG2

1.01e-03275153int:DCUN1D1
InteractionMTHFD1 interactions

DYNC2H1 ARHGAP24 FUS

1.06e-03279153int:MTHFD1
InteractionDDX3X interactions

EWSR1 ARHGAP24 FUS FLG2

1.11e-03651154int:DDX3X
InteractionC14orf119 interactions

PBX4 FUS

1.11e-0367152int:C14orf119
InteractionMETTL3 interactions

EWSR1 FUS FLG2

1.15e-03287153int:METTL3
InteractionAHCY interactions

DERL1 EWSR1 FUS

1.22e-03293153int:AHCY
InteractionMBD3 interactions

PBX4 EWSR1 FUS

1.24e-03295153int:MBD3
InteractionSMN1 interactions

KLHL5 EWSR1 FUS

1.29e-03299153int:SMN1
InteractionSRSF4 interactions

DERL1 EWSR1 FUS

1.30e-03300153int:SRSF4
InteractionCA2 interactions

EWSR1 FUS

1.35e-0374152int:CA2
InteractionTNPO1 interactions

EWSR1 ARHGAP24 FUS

1.38e-03306153int:TNPO1
InteractionNUDT5 interactions

TRIM47 EWSR1

1.39e-0375152int:NUDT5
InteractionSNAPC4 interactions

DYNC2H1 EWSR1

1.43e-0376152int:SNAPC4
InteractionAMOT interactions

EWSR1 ARHGAP24 FUS

1.46e-03312153int:AMOT
InteractionGLDC interactions

EWSR1 ARHGAP24 FUS

1.58e-03321153int:GLDC
InteractionLDHB interactions

EWSR1 ARHGAP24 FUS

1.67e-03327153int:LDHB
InteractionLRRC41 interactions

DERL1 ARHGAP24

1.70e-0383152int:LRRC41
InteractionFAM114A2 interactions

DERL1 EWSR1

1.74e-0384152int:FAM114A2
InteractionZFYVE21 interactions

EWSR1 FUS

1.74e-0384152int:ZFYVE21
InteractionCCAR2 interactions

EWSR1 ARHGAP24 FUS

1.82e-03337153int:CCAR2
InteractionSRRT interactions

EWSR1 ARHGAP24 FUS

1.86e-03340153int:SRRT
Cytoband22q11.21

RIMBP3 RIMBP3B RIMBP3C

7.53e-0611116322q11.21
CytobandEnsembl 112 genes in cytogenetic band chr22q11

RIMBP3 RIMBP3B RIMBP3C

3.87e-04419163chr22q11
GeneFamilyZinc fingers RANBP2-type |RNA binding motif containing

EWSR1 FUS

9.95e-052113289
GeneFamilyRNA binding motif containing

EWSR1 FUS

9.89e-03213132725
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DERL1 DSCAML1 ARHGAP24

1.54e-05138163a88c3ae56b0af60f6e87cabade4f21e2bbb336f2
ToppCellTCGA-Thymus-Primary_Tumor-Thymoma-Type_C|TCGA-Thymus / Sample_Type by Project: Shred V9

DERL1 ADAM8 DSCAML1

2.53e-051631632dac87d15051151ccf193760ddd8b82534c3f922
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L6_LAMP5_C1QL2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RIMBP3 RIMBP3B RIMBP3C

3.28e-0517816339889db130216655a34796e7030ffeb372465500
ToppCellCOPD-Lymphoid-B|World / Disease state, Lineage and Cell class

PBX4 KLHL5 ARHGAP24

3.68e-0518516322891ed75e25ef30dfa541cb82d85e08ce07e7d9
Diseaseamyotrophic lateral sclerosis type 6 (implicated_via_orthology)

EWSR1 FUS

5.37e-073132DOID:0060198 (implicated_via_orthology)
Diseasefrontotemporal dementia (implicated_via_orthology)

EWSR1 FUS

1.18e-0512132DOID:9255 (implicated_via_orthology)
Diseaseamyotrophic lateral sclerosis (implicated_via_orthology)

EWSR1 FUS

7.74e-0530132DOID:332 (implicated_via_orthology)
DiseaseAmyotrophic Lateral Sclerosis

EWSR1 FUS

2.92e-0458132C0002736
DiseaseRS-10-hydroxywarfarin measurement

DSCAML1 ARHGAP24

8.32e-0498132EFO_0803330
Diseasevery low density lipoprotein cholesterol measurement

PBX4 DSCAML1

5.66e-03260132EFO_0008317
Diseaseasthma, response to diisocyanate

DYNC2H1 ARHGAP24

5.70e-03261132EFO_0006995, MONDO_0004979
Diseasenose morphology measurement

DSCAML1 ARHGAP24

8.91e-03329132EFO_0007843
Diseasememory performance

DERL1 ARHGAP24

1.35e-02409132EFO_0004874

Protein segments in the cluster

PeptideGeneStartEntry
GGGNVQHRAGDWQCP

EWSR1

511

Q01844
ENNNGLGGWNSSGCK

ADGRG4

2691

Q8IZF6
LAQQCQAFWGPGGQA

ADAM8

511

P78325
QQGNGGAWPEAGGQS

RIMBP3B

546

A6NNM3
QQGNGGAWPEAGGQS

RIMBP3C

546

A6NJZ7
GARENGQPQNCGGQW

FLG2

356

Q5D862
GQPQNCGGQWRTGSS

FLG2

361

Q5D862
GGGGQQRAGDWKCPN

FUS

416

P35637
PNWNGKVCGLCGNNN

MUC19

1401

Q7Z5P9
ADQNGGGGRHNWGQG

DERL1

231

Q9BUN8
QQGEFWNRGQTGANG

KLHL5

81

Q96PQ7
PGGGCLQSQAQGSWQ

PBX4

336

Q9BYU1
PQQGQGRQNAIKCGW

ARHGAP24

11

Q8N264
VPCGGNQDQWIQCGA

DYNC2H1

4286

Q8NCM8
ARLNLQGWNNGGCPI

DSCAML1

1496

Q8TD84
ACVNQWEQLRGPGGN

TRIM47

376

Q96LD4
QQGNGGAWPEAGGQS

RIMBP3

546

Q9UFD9