Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	chloride:monoatomic cation symporter activity	SLC6A6 SLC6A11 SLC12A2 SLC12A9	8.49e-06	23	115	4	GO:0015377
GeneOntologyMolecularFunction	monoatomic anion:monoatomic cation symporter activity	SLC6A6 SLC6A11 SLC12A2 SLC12A9	1.42e-05	26	115	4	GO:0015296
GeneOntologyMolecularFunction	extracellular matrix constituent conferring elasticity	FBLN5 FBN1 FBN2	3.94e-05	12	115	3	GO:0030023
GeneOntologyMolecularFunction	MDM2/MDM4 family protein binding	RFWD3 TP63 TP73	5.10e-05	13	115	3	GO:0097371
GeneOntologyMolecularFunction	structural molecule activity conferring elasticity	FBLN5 FBN1 FBN2	6.47e-05	14	115	3	GO:0097493
GeneOntologyMolecularFunction	taurine:sodium symporter activity	SLC6A6 SLC6A11	9.83e-05	3	115	2	GO:0005369
GeneOntologyMolecularFunction	sodium:chloride symporter activity	SLC6A6 SLC6A11 SLC12A2	1.19e-04	17	115	3	GO:0015378
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	NCOA3 ID4 PPARD PRAMEF1 PRAMEF13 PRAMEF14 LRP2 PARP9 MED13 TP73	1.50e-04	417	115	10	GO:0061629
GeneOntologyMolecularFunction	monoatomic anion:sodium symporter activity	SLC6A6 SLC6A11 SLC12A2	1.69e-04	19	115	3	GO:0015373
GeneOntologyMolecularFunction	taurine transmembrane transporter activity	SLC6A6 SLC6A11	3.25e-04	5	115	2	GO:0005368
GeneOntologyMolecularFunction	calcium ion binding	FBLN5 CRELD2 CHORDC1 RYR3 FBN1 FBN2 RASGRP3 TLL1 ITSN2 LRP1 LRP2 VWA2 NOTCH4	3.79e-04	749	115	13	GO:0005509
GeneOntologyMolecularFunction	gamma-aminobutyric acid:sodium:chloride symporter activity	SLC6A6 SLC6A11	4.86e-04	6	115	2	GO:0005332
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	NCOA3 ID4 PPARD PRAMEF1 PRAMEF13 PRAMEF14 LRP2 PARP9 PRDM16 MED13 TP73	5.40e-04	582	115	11	GO:0140297
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC6A6 SLC6A11 SLC12A2 SLC12A9 SLC28A2	6.29e-04	119	115	5	GO:0015294
GeneOntologyMolecularFunction	nuclear receptor binding	NCOA3 PRAMEF1 PRAMEF13 PRAMEF14 LRP2 MED13	7.53e-04	187	115	6	GO:0016922
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	FOXS1 ZBTB33 CPHXL2 ZNF507 PPARD ZBTB1 CXXC1 ZNF568 CTCFL ZNF526 ZNF852 NFE2L1 TP63 ZNF724 PRDM16 NOTCH4 TP73	9.61e-04	1271	115	17	GO:0000987
GeneOntologyMolecularFunction	potassium:chloride symporter activity	SLC12A2 SLC12A9	1.15e-03	9	115	2	GO:0015379
GeneOntologyMolecularFunction	gamma-aminobutyric acid transmembrane transporter activity	SLC6A6 SLC6A11	1.15e-03	9	115	2	GO:0015185
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	FOXS1 NCOA3 ZBTB33 CPHXL2 ZNF507 PPARD ZBTB1 ZNF568 CTCFL ZNF526 ZNF852 NFE2L1 TP63 ZNF724 PRDM16 NOTCH4 TP73 ZNF292	1.17e-03	1412	115	18	GO:0000981
GeneOntologyMolecularFunction	solute:sodium symporter activity	SLC6A6 SLC6A11 SLC12A2 SLC28A2	1.23e-03	81	115	4	GO:0015370
GeneOntologyMolecularFunction	transcription factor binding	NCOA3 ID4 PPARD PRAMEF1 PRAMEF13 ZNF568 PRAMEF14 LRP2 PARP9 PRDM16 MED13 TP73	1.34e-03	753	115	12	GO:0008134
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNA1S KCNH7 RYR3 SLC6A6 SLC6A11 SLC12A2 SLC12A9 SLC28A2 SCNN1B	1.48e-03	465	115	9	GO:0046873
GeneOntologyMolecularFunction	symporter activity	SLC6A6 SLC6A11 SLC12A2 SLC12A9 SLC28A2	1.77e-03	150	115	5	GO:0015293
GeneOntologyBiologicalProcess	steroid metabolic process	CYP1B1 STARD4 SRD5A1 PPARD LIPA NFE2L1 SCNN1B LRP1 LRP2 GNB3	3.91e-05	376	112	10	GO:0008202
GeneOntologyBiologicalProcess	sterol metabolic process	CYP1B1 STARD4 PPARD LIPA NFE2L1 LRP1 GNB3	5.17e-05	177	112	7	GO:0016125
GeneOntologyBiologicalProcess	tube development	CYP1B1 NCOA3 IL13 FBLN5 ANGPT2 LIPA FBN1 SPINT2 OTULIN SLC12A2 HS6ST1 TP63 ADAMTS16 LRP1 LRP2 TIMELESS VAV3 RECK NOTCH4 TP73	6.12e-05	1402	112	20	GO:0035295
GeneOntologyBiologicalProcess	morphogenesis of a branching structure	NCOA3 LRRK2 SPINT2 SLC12A2 TP63 ADAMTS16 TIMELESS NOTCH4	8.34e-05	258	112	8	GO:0001763
GeneOntologyBiologicalProcess	alcohol metabolic process	CYP1B1 STARD4 PPARD ALG10B LIPA NFE2L1 SCNN1B LRP1 LRP2 GNB3	8.38e-05	412	112	10	GO:0006066
GeneOntologyBiologicalProcess	regulation of lung ciliated cell differentiation	IL13 TP73	8.74e-05	3	112	2	GO:1901246
GeneOntologyBiologicalProcess	placenta development	NCOA3 PPARD ERVW-1 ZNF568 FBN2 SPINT2 HS6ST1	1.01e-04	197	112	7	GO:0001890
GeneOntologyBiologicalProcess	transport across blood-brain barrier	SLC6A6 SLC12A2 SLC28A2 LRP1 LRP2	1.12e-04	87	112	5	GO:0150104
GeneOntologyBiologicalProcess	tube morphogenesis	CYP1B1 NCOA3 FBLN5 ANGPT2 SPINT2 OTULIN SLC12A2 HS6ST1 TP63 ADAMTS16 LRP1 LRP2 TIMELESS VAV3 RECK NOTCH4 TP73	1.18e-04	1125	112	17	GO:0035239
GeneOntologyBiologicalProcess	vascular transport	SLC6A6 SLC12A2 SLC28A2 LRP1 LRP2	1.18e-04	88	112	5	GO:0010232
GeneOntologyBiologicalProcess	isoprenoid metabolic process	CYP1B1 SRD5A1 ALG10B LIPA LRP1 LRP2	1.36e-04	144	112	6	GO:0006720
GeneOntologyBiologicalProcess	diterpenoid metabolic process	CYP1B1 SRD5A1 LIPA LRP1 LRP2	1.61e-04	94	112	5	GO:0016101
GeneOntologyBiologicalProcess	female genitalia development	SRD5A1 TP63 LRP2	1.66e-04	20	112	3	GO:0030540
GeneOntologyBiologicalProcess	sequestering of TGFbeta in extracellular matrix	FBN1 FBN2	1.74e-04	4	112	2	GO:0035583
GeneOntologyBiologicalProcess	lung ciliated cell differentiation	IL13 TP73	1.74e-04	4	112	2	GO:0061141
GeneOntologyBiologicalProcess	cholesterol metabolic process	STARD4 PPARD LIPA NFE2L1 LRP1 GNB3	2.66e-04	163	112	6	GO:0008203
GeneOntologyBiologicalProcess	terpenoid metabolic process	CYP1B1 SRD5A1 LIPA LRP1 LRP2	2.71e-04	105	112	5	GO:0006721
GeneOntologyBiologicalProcess	positive regulation of lysosomal protein catabolic process	LRP1 LRP2	2.89e-04	5	112	2	GO:1905167
GeneOntologyBiologicalProcess	chemoattraction of axon	LRP1 LRP2	2.89e-04	5	112	2	GO:0061642
GeneOntologyBiologicalProcess	morphogenesis of a branching epithelium	NCOA3 SPINT2 SLC12A2 TP63 ADAMTS16 TIMELESS NOTCH4	3.07e-04	236	112	7	GO:0061138
GeneOntologyBiologicalProcess	somatic stem cell population maintenance	PRAMEF1 PRAMEF13 TP63 PRAMEF14 PRDM16	3.08e-04	108	112	5	GO:0035019
GeneOntologyBiologicalProcess	maintenance of location	CACNA1S IL13 STARD4 PPARD RYR3 LIPA FBN1 FBN2 ASPM	3.12e-04	396	112	9	GO:0051235
GeneOntologyBiologicalProcess	stem cell population maintenance	NCOA3 PRAMEF1 PRAMEF13 TP63 PRAMEF14 ASPM PRDM16	3.15e-04	237	112	7	GO:0019827
GeneOntologyBiologicalProcess	maintenance of cell number	NCOA3 PRAMEF1 PRAMEF13 TP63 PRAMEF14 ASPM PRDM16	3.57e-04	242	112	7	GO:0098727
GeneOntologyBiologicalProcess	cholesterol storage	STARD4 PPARD LIPA	3.70e-04	26	112	3	GO:0010878
GeneOntologyBiologicalProcess	anatomical structure formation involved in morphogenesis	CYP1B1 CACNA1S FBLN5 ANGPT2 ERVW-1 PRAMEF1 PRAMEF13 PGM5 FBN2 SPINT2 OTULIN SLC12A2 HS6ST1 TP63 PRAMEF14 LRP2 VAV3 RECK NOTCH4	3.80e-04	1483	112	19	GO:0048646
GeneOntologyBiologicalProcess	secondary alcohol metabolic process	STARD4 PPARD LIPA NFE2L1 LRP1 GNB3	4.02e-04	176	112	6	GO:1902652
GeneOntologyBiologicalProcess	labyrinthine layer development	NCOA3 ERVW-1 SPINT2 HS6ST1	4.07e-04	64	112	4	GO:0060711
GeneOntologyBiologicalProcess	cellular response to organic cyclic compound	CYP1B1 NCOA3 CACNA1S SRD5A1 LRRK2 PPARD RYR3 NFE2L1 TP63 SCNN1B SPIDR	4.55e-04	605	112	11	GO:0071407
GeneOntologyBiologicalProcess	embryonic placenta development	NCOA3 ERVW-1 ZNF568 SPINT2 HS6ST1	4.82e-04	119	112	5	GO:0001892
GeneOntologyBiologicalProcess	blood vessel development	FOXS1 CYP1B1 FBLN5 ANGPT2 ERVW-1 LIPA OTULIN SLC12A2 HS6ST1 LRP1 LRP2 VAV3 RECK NOTCH4	5.08e-04	929	112	14	GO:0001568
GeneOntologyBiologicalProcess	morphogenesis of an epithelium	NCOA3 ID4 ZNF568 SPINT2 SLC12A2 TP63 ADAMTS16 SCNN1B LRP2 TIMELESS NOTCH4	5.51e-04	619	112	11	GO:0002009
GeneOntologyBiologicalProcess	positive regulation of protein catabolic process in the vacuole	LRP1 LRP2	6.03e-04	7	112	2	GO:1904352
Domain	EGF_CA	FBLN5 CRELD2 FBN1 FBN2 TLL1 LRP1 LRP2 NOTCH4	4.36e-08	86	111	8	PF07645
Domain	EGF_CA	FBLN5 CRELD2 FBN1 FBN2 TLL1 LRP1 LRP2 VWA2 NOTCH4	4.64e-08	122	111	9	SM00179
Domain	EGF-like_Ca-bd_dom	FBLN5 CRELD2 FBN1 FBN2 TLL1 LRP1 LRP2 VWA2 NOTCH4	5.35e-08	124	111	9	IPR001881
Domain	EGF_Ca-bd_CS	FBLN5 CRELD2 FBN1 FBN2 TLL1 LRP1 LRP2 NOTCH4	1.12e-07	97	111	8	IPR018097
Domain	EGF_CA	FBLN5 CRELD2 FBN1 FBN2 TLL1 LRP1 LRP2 NOTCH4	1.32e-07	99	111	8	PS01187
Domain	EGF_3	FBLN5 CRELD2 FBN1 FBN2 TLL1 LRP1 LRP2 C8A VWA2 NOTCH4 OTOG	1.55e-07	235	111	11	PS50026
Domain	EGF-type_Asp/Asn_hydroxyl_site	FBLN5 CRELD2 FBN1 FBN2 TLL1 LRP1 LRP2 NOTCH4	2.24e-07	106	111	8	IPR000152
Domain	EGF-like_dom	FBLN5 CRELD2 FBN1 FBN2 TLL1 LRP1 LRP2 C8A VWA2 NOTCH4 OTOG	2.77e-07	249	111	11	IPR000742
Domain	Growth_fac_rcpt_	BRINP3 FBLN5 CRELD2 FBN1 FBN2 LRP1 LRP2 C8A NOTCH4	3.84e-07	156	111	9	IPR009030
Domain	cEGF	FBLN5 FBN1 FBN2 LRP1 LRP2	4.03e-07	26	111	5	PF12662
Domain	cEGF	FBLN5 FBN1 FBN2 LRP1 LRP2	4.03e-07	26	111	5	IPR026823
Domain	EGF	BRINP3 FBLN5 CRELD2 FBN1 FBN2 TLL1 LRP1 LRP2 VWA2 NOTCH4	1.39e-06	235	111	10	SM00181
Domain	ASX_HYDROXYL	FBLN5 CRELD2 FBN1 FBN2 LRP1 LRP2 NOTCH4	2.20e-06	100	111	7	PS00010
Domain	EGF_1	FBLN5 CRELD2 FBN1 FBN2 TLL1 LRP1 LRP2 C8A VWA2 NOTCH4	2.90e-06	255	111	10	PS00022
Domain	EGF-like_CS	FBLN5 CRELD2 FBN1 FBN2 TLL1 LRP1 LRP2 C8A VWA2 NOTCH4	3.57e-06	261	111	10	IPR013032
Domain	EGF_2	FBLN5 CRELD2 FBN1 FBN2 TLL1 LRP1 LRP2 C8A VWA2 NOTCH4	4.09e-06	265	111	10	PS01186
Domain	Med13_N	MED13L MED13	3.50e-05	2	111	2	PF11597
Domain	Mediator_Med13_N_met/fun	MED13L MED13	3.50e-05	2	111	2	IPR021643
Domain	Med13_C	MED13L MED13	3.50e-05	2	111	2	PF06333
Domain	Mediator_Med13	MED13L MED13	3.50e-05	2	111	2	IPR009401
Domain	P53	TP63 TP73	1.05e-04	3	111	2	PF00870
Domain	P53	TP63 TP73	1.05e-04	3	111	2	PS00348
Domain	p53_DNA-bd	TP63 TP73	1.05e-04	3	111	2	IPR011615
Domain	p53_tetrameristn	TP63 TP73	1.05e-04	3	111	2	IPR010991
Domain	p53_tumour_suppressor	TP63 TP73	1.05e-04	3	111	2	IPR002117
Domain	-	TP63 TP73	1.05e-04	3	111	2	4.10.170.10
Domain	P53_tetramer	TP63 TP73	1.05e-04	3	111	2	PF07710
Domain	FBN	FBN1 FBN2	1.05e-04	3	111	2	IPR011398
Domain	p53/RUNT-type_TF_DNA-bd	TP63 TP73	5.17e-04	6	111	2	IPR012346
Domain	-	TP63 TP73	5.17e-04	6	111	2	2.60.40.720
Domain	CH	EHBP1L1 ASPM VAV3 LIMCH1	6.05e-04	65	111	4	SM00033
Domain	CAMSAP_CH	ASPM VAV3	7.21e-04	7	111	2	PF11971
Domain	TB	FBN1 FBN2	7.21e-04	7	111	2	PF00683
Domain	CAMSAP_CH	ASPM VAV3	7.21e-04	7	111	2	IPR022613
Domain	CH	EHBP1L1 ASPM VAV3 LIMCH1	8.01e-04	70	111	4	PF00307
Domain	-	EHBP1L1 ASPM VAV3 LIMCH1	8.45e-04	71	111	4	1.10.418.10
Domain	EGF	TLL1 LRP1 LRP2 VWA2 NOTCH4	9.35e-04	126	111	5	PF00008
Domain	CH	EHBP1L1 ASPM VAV3 LIMCH1	9.38e-04	73	111	4	PS50021
Domain	SLC12_C	SLC12A2 SLC12A9	9.57e-04	8	111	2	IPR018491
Domain	-	FBN1 FBN2	9.57e-04	8	111	2	3.90.290.10
Domain	SLC12	SLC12A2 SLC12A9	9.57e-04	8	111	2	PF03522
Domain	CH-domain	EHBP1L1 ASPM VAV3 LIMCH1	1.04e-03	75	111	4	IPR001715
Domain	TB_dom	FBN1 FBN2	1.23e-03	9	111	2	IPR017878
Domain	TB	FBN1 FBN2	1.23e-03	9	111	2	PS51364
Domain	MAC_perforin	BRINP3 C8A	1.53e-03	10	111	2	IPR001862
Domain	LDLR_class-A_CS	LRP1 LRP2 C8A	1.72e-03	40	111	3	IPR023415
Domain	MACPF	BRINP3 C8A	1.86e-03	11	111	2	PF01823
Domain	SM22_calponin	VAV3 LIMCH1	1.86e-03	11	111	2	IPR003096
Domain	SAM_2	PPFIA1 TP63 TP73	2.12e-03	43	111	3	PF07647
Domain	MACPF	BRINP3 C8A	2.22e-03	12	111	2	IPR020864
Domain	MACPF	BRINP3 C8A	2.22e-03	12	111	2	SM00457
Domain	Ldl_recept_a	LRP1 LRP2 C8A	2.42e-03	45	111	3	PF00057
Domain	-	LRP1 LRP2 C8A	2.58e-03	46	111	3	4.10.400.10
Domain	LDLRA_1	LRP1 LRP2 C8A	2.91e-03	48	111	3	PS01209
Domain	TIL_dom	LRP2 OTOG	3.04e-03	14	111	2	IPR002919
Domain	Ldl_recept_b	LRP1 LRP2	3.04e-03	14	111	2	PF00058
Domain	LDLRB	LRP1 LRP2	3.04e-03	14	111	2	PS51120
Domain	LDrepeatLR_classA_rpt	LRP1 LRP2 C8A	3.09e-03	49	111	3	IPR002172
Domain	LDLa	LRP1 LRP2 C8A	3.09e-03	49	111	3	SM00192
Domain	LDLRA_2	LRP1 LRP2 C8A	3.09e-03	49	111	3	PS50068
Domain	LY	LRP1 LRP2	3.49e-03	15	111	2	SM00135
Domain	LDLR_classB_rpt	LRP1 LRP2	3.49e-03	15	111	2	IPR000033
Domain	NA_NEUROTRAN_SYMP_2	SLC6A6 SLC6A11	5.03e-03	18	111	2	PS00754
Domain	SNF	SLC6A6 SLC6A11	5.60e-03	19	111	2	PF00209
Domain	Na/ntran_symport	SLC6A6 SLC6A11	5.60e-03	19	111	2	IPR000175
Domain	NA_NEUROTRAN_SYMP_1	SLC6A6 SLC6A11	5.60e-03	19	111	2	PS00610
Domain	NA_NEUROTRAN_SYMP_3	SLC6A6 SLC6A11	5.60e-03	19	111	2	PS50267
Domain	PRAME_family	PRAMEF1 PRAMEF13	5.60e-03	19	111	2	IPR026271
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	MED13L FBN1 FBN2 RASGRP3 LRP1 LRP2 LIMCH1 ZNF292	1.07e-10	71	116	8	33541421
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	FOXS1 NCOA3 ZBTB33 POLR2I ID4 PPARD ZBTB1 CXXC1 IVNS1ABP CNOT6L NFE2L1 TP63 TIMELESS TP73 ZNF292	2.43e-07	877	116	15	20211142
Pubmed	Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.	FBLN5 FBN1 FBN2	3.60e-07	5	116	3	17255108
Pubmed	Genome-wide meta-analysis identifies new susceptibility loci for migraine.	GFRA2 FBN2 LRP1 LIMCH1 PRDM16	6.58e-06	78	116	5	23793025
Pubmed	Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.	FBN1 FBN2	1.10e-05	2	116	2	12399449
Pubmed	Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.	FBN1 FBN2	1.10e-05	2	116	2	21851253
Pubmed	New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.	FBN1 FBN2	1.10e-05	2	116	2	30044367
Pubmed	Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.	FBN1 FBN2	1.10e-05	2	116	2	21440062
Pubmed	MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.	FBN1 FBN2	1.10e-05	2	116	2	15131124
Pubmed	Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma.	TP63 TP73	1.10e-05	2	116	2	17018588
Pubmed	Microfibril structure masks fibrillin-2 in postnatal tissues.	FBN1 FBN2	1.10e-05	2	116	2	20404337
Pubmed	Conformational stability and activity of p73 require a second helix in the tetramerization domain.	TP63 TP73	1.10e-05	2	116	2	19763140
Pubmed	Fibrillln mutations in Marfan syndrome and related phenotypes.	FBN1 FBN2	1.10e-05	2	116	2	8791520
Pubmed	p73 and p63 regulate the expression of fibroblast growth factor receptor 3.	TP63 TP73	1.10e-05	2	116	2	20298673
Pubmed	Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.	FBN1 FBN2	1.10e-05	2	116	2	8307578
Pubmed	Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.	FBN1 FBN2	1.10e-05	2	116	2	7744963
Pubmed	Mutation of the Na-K-Cl co-transporter gene Slc12a2 results in deafness in mice.	FBN2 SLC12A2	1.10e-05	2	116	2	10401008
Pubmed	Fibrillin microfibrils in bone physiology.	FBN1 FBN2	1.10e-05	2	116	2	26408953
Pubmed	Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.	FBN1 FBN2	1.10e-05	2	116	2	18006876
Pubmed	Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.	FBN1 FBN2	1.10e-05	2	116	2	24833718
Pubmed	Exome sequencing identified new mutations in a Marfan syndrome family.	FBN1 LRP1	1.10e-05	2	116	2	24484584
Pubmed	p63 and p73 do not contribute to p53-mediated lymphoma suppressor activity in vivo.	TP63 TP73	1.10e-05	2	116	2	16007185
Pubmed	Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.	FBN1 FBN2	1.10e-05	2	116	2	24265020
Pubmed	In vivo studies of mutant fibrillin-1 microfibrils.	FBN1 FBN2	1.10e-05	2	116	2	20529844
Pubmed	The Role of p63 and p73 in tumor formation and progression: coming of age toward clinical usefulness. Commentary re: F. Koga et al., Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder. Clin. Cancer Res., 9: 5501-5507, 2003, and P. Puig et al., p73 Expression in human normal and tumor tissues: loss of p73alpha expression is associated with tumor progression in bladder Cancer. Clin. Cancer Res., 9: 5642-5651, 2003.	TP63 TP73	1.10e-05	2	116	2	14654522
Pubmed	Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.	FBN1 FBN2	1.10e-05	2	116	2	23133647
Pubmed	The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers.	TP63 TP73	1.10e-05	2	116	2	17446929
Pubmed	Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.	FBN1 FBN2	1.10e-05	2	116	2	1852206
Pubmed	The original shaker-with-syndactylism mutation (sy) is a contiguous gene deletion syndrome.	FBN2 SLC12A2	1.10e-05	2	116	2	9799839
Pubmed	Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.	FBN1 FBN2	1.10e-05	2	116	2	12429739
Pubmed	Mediator complex component MED13 regulates zygotic genome activation and is required for postimplantation development in the mouse.	MED13L MED13	1.10e-05	2	116	2	29325037
Pubmed	Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.	LRP1 LRP2	1.10e-05	2	116	2	34445520
Pubmed	p63 and p73 expression in extrahepatic bile duct carcinoma and their clinical significance.	TP63 TP73	1.10e-05	2	116	2	17385050
Pubmed	p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis.	TP63 TP73	1.10e-05	2	116	2	16413471
Pubmed	The role of p53 protein family in gastrointestinal malignancies.	TP63 TP73	1.10e-05	2	116	2	16557273
Pubmed	Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.	FBN1 FBN2	1.10e-05	2	116	2	12524050
Pubmed	Mutation of the gene encoding fibrillin-2 results in syndactyly in mice.	FBN2 SLC12A2	1.10e-05	2	116	2	11285249
Pubmed	The 5th International p63/p73 Workshop: much more than just tumour suppression.	TP63 TP73	1.10e-05	2	116	2	22240899
Pubmed	Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization.	TP63 TP73	1.10e-05	2	116	2	27716744
Pubmed	Polymorphisms in the p63 and p73 genes are associated with ovarian cancer risk and clinicopathological variables.	TP63 TP73	1.10e-05	2	116	2	23095717
Pubmed	Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.	FBN1 FBN2	1.10e-05	2	116	2	8120105
Pubmed	The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.	FBN1 FBN2	1.10e-05	2	116	2	35419902
Pubmed	Fibrillin assembly: dimer formation mediated by amino-terminal sequences.	FBN1 FBN2	1.10e-05	2	116	2	10504303
Pubmed	P634A4 and TAp73 immunocytochemistry in liquid-based cervical cytology--potential biomarkers for diagnosis and progress prediction of cervical neoplasia.	TP63 TP73	1.10e-05	2	116	2	20081800
Pubmed	Distinct p63 and p73 Protein Interactions Predict Specific Functions in mRNA Splicing and Polyploidy Control in Epithelia.	TP63 TP73	1.10e-05	2	116	2	33375680
Pubmed	p63 and p73: roles in development and tumor formation.	TP63 TP73	1.10e-05	2	116	2	15280445
Pubmed	p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53.	TP63 TP73	1.10e-05	2	116	2	10373484
Pubmed	TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.	TP63 TP73	1.10e-05	2	116	2	24983500
Pubmed	Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.	FBN1 FBN2	1.10e-05	2	116	2	25524144
Pubmed	Role of p63 and p73 isoforms on the cell death in patients with hepatocellular carcinoma submitted to orthotopic liver transplantation.	TP63 TP73	1.10e-05	2	116	2	28350813
Pubmed	Genome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo.	TP63 TP73	1.10e-05	2	116	2	20644729
Pubmed	Tissue-specific expression of p73 and p63 isoforms in human tissues.	TP63 TP73	1.10e-05	2	116	2	34315849
Pubmed	Fibrillins 1 and 2 perform partially overlapping functions during aortic development.	FBN1 FBN2	1.10e-05	2	116	2	16407178
Pubmed	p63 antagonizes p53 to promote the survival of embryonic neural precursor cells.	TP63 TP73	1.10e-05	2	116	2	19458240
Pubmed	N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.	FBN1 FBN2	1.10e-05	2	116	2	10359653
Pubmed	While p73 is essential, p63 is completely dispensable for the development of the central nervous system.	TP63 TP73	1.10e-05	2	116	2	21293190
Pubmed	Blood-Brain Barrier: From Physiology to Disease and Back.	SLC6A6 SLC12A2 SLC28A2 LRP1 LRP2	2.80e-05	105	116	5	30280653
Pubmed	Establishment and Dysfunction of the Blood-Brain Barrier.	SLC6A6 SLC28A2 LRP1 LRP2	2.81e-05	52	116	4	26590417
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF1 PRAMEF13 PRAMEF14	2.84e-05	18	116	3	23894331
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF1 PRAMEF13 PRAMEF14	2.84e-05	18	116	3	12890732
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF1 PRAMEF13 PRAMEF14	2.84e-05	18	116	3	29731491
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF1 PRAMEF13 PRAMEF14	2.84e-05	18	116	3	14675769
Pubmed	Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.	CYP1B1 IL13 TRAF3 ESCO2 SLC28A2 TP73	3.17e-05	179	116	6	19074885
Pubmed	Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.	FBN1 FBN2	3.30e-05	3	116	2	10825173
Pubmed	Neuronal survival and p73/p63/p53: a family affair.	TP63 TP73	3.30e-05	3	116	2	15359011
Pubmed	The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells.	TP63 TP73	3.30e-05	3	116	2	16181796
Pubmed	Glyoxalase II, a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73, is a pro-survival factor of the p53 family.	TP63 TP73	3.30e-05	3	116	2	16831876
Pubmed	The integrin alpha(v)beta(3-5) ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER(+) and erbB2(+) breast cancers.	TP63 TP73	3.30e-05	3	116	2	21127199
Pubmed	Regulation and function of the p53-related proteins: same family, different rules.	TP63 TP73	3.30e-05	3	116	2	10754563
Pubmed	p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress.	TP63 TP73	3.30e-05	3	116	2	16601753
Pubmed	Differential expression of p53 gene family members p63 and p73 in head and neck squamous tumorigenesis.	TP63 TP73	3.30e-05	3	116	2	11957139
Pubmed	Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.	FBN1 FBN2	3.30e-05	3	116	2	30201140
Pubmed	Reversion-inducing cysteine-rich protein with Kazal motifs and MT1-MMP promote the formation of robust fibrillin fibers.	FBN1 RECK	3.30e-05	3	116	2	32730638
Pubmed	p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells.	TP63 TP73	3.30e-05	3	116	2	24809925
Pubmed	Crystal structures of the DNA-binding domain tetramer of the p53 tumor suppressor family member p73 bound to different full-site response elements.	TP63 TP73	3.30e-05	3	116	2	23243311
Pubmed	p53, p63 and p73--solos, alliances and feuds among family members.	TP63 TP73	3.30e-05	3	116	2	11825686
Pubmed	The dominant-negative interplay between p53, p63 and p73: A family affair.	TP63 TP73	3.30e-05	3	116	2	27589690
Pubmed	ΔNp63 regulates select routes of reprogramming via multiple mechanisms.	TP63 TP73	3.30e-05	3	116	2	24013722
Pubmed	Fibulin-5 interacts with fibrillin-1 molecules and microfibrils.	FBLN5 FBN1	3.30e-05	3	116	2	15790312
Pubmed	Genetics of migraine in the age of genome-wide association studies.	LRP1 PRDM16	3.30e-05	3	116	2	22072275
Pubmed	Interaction between TP63 and MDM2 genes and the risk of recurrent pregnancy loss.	TP63 TP73	3.30e-05	3	116	2	25218545
Pubmed	[Clinical significance of the expression of p53, p63 and p73 in nasal and paranasal sinus carcinoma].	TP63 TP73	3.30e-05	3	116	2	19119599
Pubmed	p63 and p73 are not required for the development and p53-dependent apoptosis of T cells.	TP63 TP73	3.30e-05	3	116	2	15261144
Pubmed	Diverse p63 and p73 isoforms regulate Δ133p53 expression through modulation of the internal TP53 promoter activity.	TP63 TP73	3.30e-05	3	116	2	22075982
Pubmed	Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family.	TP63 TP73	3.30e-05	3	116	2	15837625
Pubmed	Structural evolution of p53, p63, and p73: implication for heterotetramer formation.	TP63 TP73	3.30e-05	3	116	2	19815500
Pubmed	deltaEF1 repressor controls selectively p53 family members during differentiation.	TP63 TP73	3.30e-05	3	116	2	16007124
Pubmed	Intrinsic aggregation propensity of the p63 and p73 TI domains correlates with p53R175H interaction and suggests further significance of aggregation events in the p53 family.	TP63 TP73	3.30e-05	3	116	2	27447112
Pubmed	p63 and p73 are required for p53-dependent apoptosis in response to DNA damage.	TP63 TP73	3.30e-05	3	116	2	11932750
Pubmed	Tumor suppressors p53, p63TAα, p63TAy, p73α, and p73β use distinct pathways to repress telomerase expression.	TP63 TP73	3.30e-05	3	116	2	22496369
Pubmed	A novel response element confers p63- and p73-specific activation of the WNT4 promoter.	TP63 TP73	3.30e-05	3	116	2	16343436
Pubmed	Novel therapeutic interventions for p53-altered tumors through manipulation of its family members, p63 and p73.	TP63 TP73	3.30e-05	3	116	2	26652033
Pubmed	Differential expression of p53, p63 and p73 proteins in human buccal squamous-cell carcinomas.	TP63 TP73	3.30e-05	3	116	2	12969350
Pubmed	Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.	FBN1 FBN2	3.30e-05	3	116	2	20855508
Pubmed	Evaluating the Influence of a G-Quadruplex Prone Sequence on the Transactivation Potential by Wild-Type and/or Mutant P53 Family Proteins through a Yeast-Based Functional Assay.	TP63 TP73	3.30e-05	3	116	2	33672023
Pubmed	p53 Family isoforms.	TP63 TP73	3.30e-05	3	116	2	18289041
Pubmed	Differential regulation of vitamin D receptor (VDR) by the p53 Family: p73-dependent induction of VDR upon DNA damage.	TP63 TP73	3.30e-05	3	116	2	17716971
Pubmed	iASPP inhibits p53-independent apoptosis by inhibiting transcriptional activity of p63/p73 on promoters of proapoptotic genes.	TP63 TP73	3.30e-05	3	116	2	22538442
Pubmed	The emerging p53 gene family.	TP63 TP73	3.30e-05	3	116	2	10203277
Pubmed	Deciphering the Role of the rs2651899, rs10166942, and rs11172113 Polymorphisms in Migraine: A Meta-Analysis.	LRP1 PRDM16	3.30e-05	3	116	2	35454329
Interaction	ZDHHC15 interactions	MED13L FBN1 FBN2 RASGRP3 LRP1 LRP2 LIMCH1 ZNF292	3.66e-07	125	108	8	int:ZDHHC15
Interaction	ZFP41 interactions	FBLN5 CRELD2 FBN1 FBN2 LRP1 LRP2	5.98e-07	57	108	6	int:ZFP41
Interaction	NTN5 interactions	FBLN5 FBN1 FBN2 LRP2	7.63e-06	24	108	4	int:NTN5
Cytoband	5p15	SRD5A1 ADAMTS16	1.32e-04	7	116	2	5p15
GeneFamily	PRAME family	PRAMEF1 PRAMEF13 PRAMEF14	1.76e-04	24	83	3	686
Coexpression	INGRAM_SHH_TARGETS_UP	CYP1B1 PRAMEF1 PRAMEF13 SLC6A6 FBN1 FBN2 PRAMEF14	5.26e-06	156	113	7	MM550
ToppCell	E12.5-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FOXS1 CACNA1S FBLN5 ANGPT2 CRELD2 FBN1 VAV3	4.21e-07	177	116	7	5cdf413f82376a95467322b16d10b0d1e7557e2d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 PSMA1 HS6ST1 ADAMTS16 SCNN1B LIMCH1 PRDM16	4.71e-07	180	116	7	788d5fbf688365b5d92d3aa19b9f8e9448f8be5a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 IVNS1ABP CNOT6L ADAMTS16 VAV3 LIMCH1 PRDM16	6.32e-07	188	116	7	bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 IVNS1ABP CNOT6L ADAMTS16 VAV3 LIMCH1 PRDM16	6.32e-07	188	116	7	eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo1_Itga4\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CYP1B1 BRINP3 ID4 RYR3 VAV3 LIMCH1	2.15e-06	144	116	6	7de962346ba9653d90dd13bb7d977fe44d200bba
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BRINP3 IVNS1ABP HS6ST1 SCNN1B LRP2 PRDM16	2.83e-06	151	116	6	f4f7156b2c0cfc78fd1841e07c9915d97ced561f
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1\|E16.5-samps / Age Group, Lineage, Cell class and subclass	FBLN5 MED13L RYR3 FBN1 LRP1 LIMCH1	4.40e-06	163	116	6	f1ec2625b52664308968b01d8e0275e1e0751480
ToppCell	LPS-antiTNF-Epithelial_airway-Mes-Epi-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STARD4 RYR3 ESCO2 ASPM TIMELESS TP73	4.56e-06	164	116	6	4307b002fb41ddfc7ab8a6bca66a60942c250052
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PSMA1 FRMPD1 ADAMTS16 SCNN1B LIMCH1 OR8D4	4.56e-06	164	116	6	6fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCell	LPS-antiTNF-Epithelial_airway-Mes-Epi-like-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STARD4 RYR3 ESCO2 ASPM TIMELESS TP73	4.56e-06	164	116	6	1d84aa5b925f502ee9c5fa39714490f613a58028
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PSMA1 ESCO2 ZNF724 SCNN1B TIMELESS TP73	5.06e-06	167	116	6	108ae6221c6edc63c0ec42c42471b3a15a594043
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PGM5 TP63 RASGRP3 TLL1 SCNN1B VAV3	6.62e-06	175	116	6	43be63976da5ad0764d24d90919a77ce46068f52
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 FRMPD1 IVNS1ABP ADAMTS16 LIMCH1 PRDM16	7.53e-06	179	116	6	666072c0e8448dbaec1683d18368ec2502453f90
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR3 FBN2 ADAMTS16 LRP2 UNC5D OTOG	8.81e-06	184	116	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D122\|Adult / Lineage, Cell type, age group and donor	BRINP3 FBLN5 RIPOR3 COLGALT2 FBN1 LRFN5	8.81e-06	184	116	6	2b7e6f91e11c228f0521e099886867d9e998e78d
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR3 FBN2 ADAMTS16 LRP2 UNC5D OTOG	8.81e-06	184	116	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR3 FBN2 ADAMTS16 LRP2 UNC5D OTOG	8.81e-06	184	116	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Bladder-nan-24m-Endothelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NXPE2 RASGRP3 TLL1 SLC28A2 TIMELESS LIMCH1	9.09e-06	185	116	6	90caab8d9361a541c5d5121c97c3f1cdffeeae4a
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	GFRA2 RYR3 PGM5 FBN1 FBN2 PRDM16	9.37e-06	186	116	6	4d68ee3d32f7ef884faf402ef92b31b0eb4656f1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 ESCO2 FBN1 LRFN5 ASPM TP73	9.66e-06	187	116	6	e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 ESCO2 FBN1 LRFN5 ASPM TP73	9.66e-06	187	116	6	cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PGM5 HS6ST1 ADAMTS16 SCNN1B LIMCH1 PRDM16	9.66e-06	187	116	6	f6217d0dd425eac76900b44a4e48f45475f3ac36
ToppCell	facs-Heart-LV-18m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A6 RASGRP3 SLC28A2 LIMCH1 PRDM16 NOTCH4	9.96e-06	188	116	6	ed11e26ff4ef3d6314b5f5734062519b9aa285c1
ToppCell	facs-Heart-LV-18m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A6 RASGRP3 SLC28A2 LIMCH1 PRDM16 NOTCH4	9.96e-06	188	116	6	e5a8ca4613ab0bf1584b9e78959adf41d0bf379f
ToppCell	facs-Heart-LV-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A6 RASGRP3 SLC28A2 LIMCH1 PRDM16 NOTCH4	9.96e-06	188	116	6	0fc3a6562e6895f6fe7a93397eae842a75c60c93
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-B_plasma-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	NCOA3 CRELD2 TP63 RASGRP3 ASPM SCNN1B	1.03e-05	189	116	6	59e6fec454de621119571d4a8ec48be3bf02a32e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PSMA1 HS6ST1 ADAMTS16 SCNN1B LIMCH1 PRDM16	1.03e-05	189	116	6	8ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 IVNS1ABP CNOT6L ADAMTS16 VAV3 PRDM16	1.03e-05	189	116	6	977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCell	E17.5-Endothelial-large_vessel_endothelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FBLN5 PGM5 SLC6A6 FBN1 RASGRP3 TLL1	1.03e-05	189	116	6	360f09f46231a83f99d8fa0158b72a38068e1642
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-B_plasma\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	NCOA3 CRELD2 TP63 RASGRP3 ASPM SCNN1B	1.03e-05	189	116	6	43f25fb7257eab05df921ffcd5a6e49c78a03e3a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PSMA1 HS6ST1 ADAMTS16 SCNN1B LIMCH1 PRDM16	1.06e-05	190	116	6	4836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PGM5 HS6ST1 ADAMTS16 SCNN1B LIMCH1 PRDM16	1.06e-05	190	116	6	b7f8c2bb9459f1d7c1690069dd5a25a81a57cc84
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 IVNS1ABP ADAMTS16 VAV3 LIMCH1 PRDM16	1.06e-05	190	116	6	e252e925600e6457fa6e362a55217f4cffa75cdb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRRK2 SLC6A6 TLL1 ADAMTS16 LRP2 UNC5D	1.09e-05	191	116	6	1cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCell	Control-Stromal-SMC\|Stromal / Disease state, Lineage and Cell class	FOXS1 ANGPT2 SPEG ID4 PGM5 PRDM16	1.09e-05	191	116	6	2da83c493e60ad0278848957645277d76737a188
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PGM5 HS6ST1 ADAMTS16 SCNN1B LIMCH1 PRDM16	1.09e-05	191	116	6	96b78b4e819ea6052334bfcbc7abbf35897df885
ToppCell	droplet-Kidney-nan-18m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXS1 CYP1B1 FBLN5 FBN1 LRP1 TXNDC8	1.12e-05	192	116	6	38d7a24ae205ef91ed2e0f402d8022f2a9cdb243
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CYP1B1 FBLN5 RIPOR3 FBN1 LRFN5 LRP1	1.12e-05	192	116	6	bc84b9ce01b4d826a682842ab8a395dac9b91183
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXS1 CYP1B1 FBLN5 FBN1 LRP1 TXNDC8	1.12e-05	192	116	6	04d155897ed075c359933080e36a4ab2150b6e9f
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYP1B1 ANGPT2 PGM5 RASGRP3 TLL1 SCNN1B	1.12e-05	192	116	6	5388f3115ab285f3f3001af1d71543ed64b9e044
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D175\|Adult / Lineage, Cell type, age group and donor	TRAF3 IVNS1ABP SLC6A6 EHBP1L1 LRP1 VAV3	1.12e-05	192	116	6	733491e932350e3c216a626cc49c3cd3fe970a82
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXS1 CYP1B1 FBLN5 FBN1 LRP1 TXNDC8	1.12e-05	192	116	6	84149a5c6c3b3c9b86aed77cf8e72d99ef099fab
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_BHLHE22\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NCOA3 BRINP3 KCNH7 LRRK2 ID4 VAV3	1.12e-05	192	116	6	25460ca9ebd3d49f666394cf99ab77a5e8f77250
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CYP1B1 FBLN5 RIPOR3 FBN1 LRFN5 LRP1	1.12e-05	192	116	6	0ab1176cfbb0de8dd1f22c6e2c41265cf6c10ee1
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1\|TCGA-Endometrium / Sample_Type by Project: Shred V9	STARD4 RFWD3 ESCO2 SLC6A6 SLC12A2 HSDL1	1.16e-05	193	116	6	c2673d86f7d7b849788036032a93a6d136a70040
ToppCell	COVID-19-kidney-CD-PC\|kidney / Disease (COVID-19 only), tissue and cell type	PGM5 HS6ST1 ADAMTS16 SCNN1B LIMCH1 PRDM16	1.16e-05	193	116	6	738689d009e4b118d7ce3171a207294b95cbe78b
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYP1B1 ANGPT2 PGM5 RASGRP3 TLL1 SCNN1B	1.16e-05	193	116	6	ef007b736da56529ec628fc3df86a335e7ec3f18
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBLN5 GFRA2 PGM5 FBN1 LRP1 LIMCH1	1.23e-05	195	116	6	3a0cad69cfc150a27a0666f612f5294c817197d7
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBLN5 GFRA2 PGM5 FBN1 LRP1 LIMCH1	1.23e-05	195	116	6	2b8ee7990267bb52b7e6ae03f509ffebf8908122
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 SRD5A1 IVNS1ABP CNOT6L SLC12A2 VAV3	1.23e-05	195	116	6	a38d9dc6192aea673d96fda6b25e81223fda3abf
ToppCell	Fibroblasts-Pericytes\|Fibroblasts / lung cells shred on cell class, cell subclass, sample id	FOXS1 ANGPT2 SPEG ID4 PGM5 PRDM16	1.23e-05	195	116	6	c2ebc0b33bda9b35b9ef26d69e5d2c6acfdb6ff1
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RYR3 PGM5 RASGRP3 TLL1 LIMCH1 NOTCH4	1.26e-05	196	116	6	22767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RYR3 PGM5 RASGRP3 TLL1 LIMCH1 NOTCH4	1.26e-05	196	116	6	adee900dcd16dbaba15c58bdcace09ba20214950
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Adventitial_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CYP1B1 FBLN5 COLGALT2 FBN1 FBN2 ADAMTS16	1.26e-05	196	116	6	eed9fe83ffc1f79493b70778962a671dd9f481e0
ToppCell	Tracheal-10x5prime-Stromal-Peri/Epineurial_\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FOXS1 CYP1B1 GFRA2 FBN1 FBN2 LRP1	1.30e-05	197	116	6	2cb1f557ce1400398975de94638126b4522567f3
ToppCell	5'-Adult-LargeIntestine-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYP1B1 ANGPT2 PGM5 TLL1 LIMCH1 NOTCH4	1.38e-05	199	116	6	ffebd99d55d31cf51b4878b2690ed0b9b3799223
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_1-AF2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYP1B1 FBLN5 RIPOR3 FBN1 LRFN5 LRP1	1.41e-05	200	116	6	44317fbf4d1480a37b50ab2777bf1a3e4fc0c05f
ToppCell	medial-mesenchymal-Adventitial_Fibroblast\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CYP1B1 BRINP3 FBLN5 ID4 FBN1 LRFN5	1.41e-05	200	116	6	87a5a0c252c08ba10316c21f6a9d5244c4d98c74
ToppCell	medial-2-mesenchymal-Adventitial_Fibroblast\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CYP1B1 BRINP3 FBLN5 ID4 FBN1 LRFN5	1.41e-05	200	116	6	6ccf44f10d2cee5f48b8f05bd9a1b94057184d56
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CYP1B1 FBLN5 LRRK2 FBN1 LRFN5 LRP1	1.41e-05	200	116	6	0c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCell	medial-mesenchymal-Adventitial_Fibroblast-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CYP1B1 BRINP3 FBLN5 ID4 FBN1 LRFN5	1.41e-05	200	116	6	5ee1318a74ca28a81bd81c20c611de84c17636b0
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_1\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYP1B1 FBLN5 RIPOR3 FBN1 LRFN5 LRP1	1.41e-05	200	116	6	440dda48b09c6a8581b7ca634b0d67f1ecacf65e
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FBLN5 GFRA2 RYR3 SPINT2 PRDM16	1.45e-05	118	116	5	e5202fadb3f9d91e56337ddad1666196ec748d87
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_low-phase\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SPEG ESCO2 SPINT2 ASPM LYPD8	3.78e-05	144	116	5	f6061dd965a2b2fe6ad864f8aecc06d2e74881ce
ToppCell	facs-Trachea-nan-3m-Myeloid-lymphocyte_of_B_lineage\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S RFWD3 ESCO2 ASPM ZNF292	5.70e-05	157	116	5	0fecc14959c4c9efc19d5c06475a890e0a30f148
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR64 RYR3 FBN2 TLL1 LRP2	6.23e-05	160	116	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR64 RYR3 FBN2 TLL1 LRP2	6.23e-05	160	116	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	VE-CD8-naive_CD4\|VE / Condition, Cell_class and T cell subcluster	WDR64 PPFIA1 ZNF507 SLC12A2 ZNF724	6.23e-05	160	116	5	255d2a150bfe19ee3d4d34533feb9c37ce73d225
ToppCell	facs-Marrow-B-cells-18m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S CRELD2 NXPE2 TXNDC8 TP73	7.21e-05	165	116	5	361a605d8f833d9ec54b120480dce397da35f9c3
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor_MEMP\|bone_marrow / Manually curated celltypes from each tissue	RIPOR3 DYDC2 PGM5 FBN1 VWA2	7.42e-05	166	116	5	9788486582cc2c5f28b9ea015e235732f9fefb1e
ToppCell	COVID-19-kidney-Lymphatic_EC\|kidney / Disease (COVID-19 only), tissue and cell type	ANGPT2 PGM5 FBN1 RASGRP3 GNB3	7.63e-05	167	116	5	97d0fea1f41c1c00e36d9b5c4c1f0dd85087056f
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L3-5_THEMIS_UBE2F\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	STARD4 LIPA TLL1 ADAMTS16 LYPD8	7.85e-05	168	116	5	bfa1491e8d433933003778b274710d3a16d973cb
ToppCell	Bronchial_Biopsy-Immune-T_and_NK\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	IL13 FBLN5 RYR3 ASPM RECK	7.85e-05	168	116	5	435b2f238fbb3f50427e8cdecf2220615015153c
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN5 FBN1 ADAMTS16 LRP1 RECK	8.07e-05	169	116	5	bb43abad2c049b7f4d307737347290e01b3339a3
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ESCO2 ASPM ZNF724 TIMELESS TP73	8.07e-05	169	116	5	0bc8ef341ce307b19018d4ac8de0a4d04254209d
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN5 FBN1 ADAMTS16 LRP1 RECK	8.07e-05	169	116	5	5f18e3f40a5b1b167903f37516ec8181e889c7c5
ToppCell	Smart-seq2-blood_(Smart-seq2)\|Smart-seq2 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CYP1B1 LRRK2 EHBP1L1 SLC12A9 LRP1	8.07e-05	169	116	5	0ee74cc97a2db9cc16dc73424f74747afe13af90
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN5 FBN1 ADAMTS16 LRP1 RECK	8.07e-05	169	116	5	8bfa2d3bb541d02f55d7c95b8fd156c8403befca
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HGD SPINT2 SLC12A2 LRP2 UNC5D	8.30e-05	170	116	5	4ce81608111b9ee7cb974dad2c182f38db3dcd79
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D122\|Adult / Lineage, Cell type, age group and donor	PGM5 FBN1 RASGRP3 TLL1 VAV3	9.01e-05	173	116	5	dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell\|Adult / Lineage, Cell type, age group and donor	SPEG RYR3 PGM5 SLC6A11 LYPD8	9.01e-05	173	116	5	a5331721bd9f9a66530dd4ffe28cb3a5a8cad8fc
ToppCell	facs-Aorta-Heart-24m-Epithelial\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPINT2 LYPD5 ASPM LYPD8 TM4SF20	9.01e-05	173	116	5	86aa15cf5c450465290de1c3dd9ff9d355d9cbee
ToppCell	facs-Aorta-Heart-24m-Epithelial-epithelial_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPINT2 LYPD5 ASPM LYPD8 TM4SF20	9.01e-05	173	116	5	2216e36c77cb3b531508f897c1e7e01b94037d5e
ToppCell	facs-Aorta-Heart-24m-Epithelial-nan\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPINT2 LYPD5 ASPM LYPD8 TM4SF20	9.01e-05	173	116	5	a3a09fe5cdb9e91e0880e247bf8d974fe29c6fa8
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ANGPT2 SPEG NXPE2 ZNF852 GNB3	9.51e-05	175	116	5	b80fe906043b3cb0b3ba761aadc9dc1c364aa1bf
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KCNH7 PGM5 ESCO2 TLL1 ASPM	9.51e-05	175	116	5	d43ae33a6256606ce848247cad32d74f21b38988
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ANGPT2 SPEG NXPE2 ZNF852 GNB3	9.51e-05	175	116	5	067c7d89cfdf6ebf70692df64b9b79d752f093dd
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GFRA2 FBN1 SLC12A9 DENND2C PRDM16	9.77e-05	176	116	5	3766e0533b103ec92ac75eba3df02e287efc53fa
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBLN5 STARD4 SLC6A6 RASGRP3 NOTCH4	9.77e-05	176	116	5	77516048aefbe1f48e825052756df0c310c1c486
ToppCell	Control-Neuronal_cells-Neuronal_cells\|Control / group, cell type (main and fine annotations)	ANGPT2 PGM5 RASGRP3 TLL1 VAV3	9.77e-05	176	116	5	98c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-late_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GFRA2 FBN1 SLC12A9 DENND2C PRDM16	9.77e-05	176	116	5	aa1bada2175d8370fc71939a607407155259d195
ToppCell	Control-Neuronal_cells\|Control / group, cell type (main and fine annotations)	ANGPT2 PGM5 RASGRP3 TLL1 VAV3	9.77e-05	176	116	5	c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBLN5 STARD4 SLC6A6 RASGRP3 NOTCH4	9.77e-05	176	116	5	96779273b94345250cf53ba671203345b43d9e00
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYP1B1 WDR64 PGM5 TP63 RASGRP3	1.00e-04	177	116	5	76f5df101c693e5fa61554244d877fc8169ee66f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANGPT2 PGM5 FBN1 TP63 RASGRP3	1.00e-04	177	116	5	c274fbdc141855ff4581d437d4997c64cc193278
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGD BRINP3 LRRK2 VAV3 UNC5D	1.00e-04	177	116	5	f902600c639087664316b3cf30cab243bc3d1c5c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANGPT2 PGM5 FBN1 TP63 RASGRP3	1.00e-04	177	116	5	f5e6df5cafd003bbfbb3b634ee58d0b1e2be5cc7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 IVNS1ABP CNOT6L SLC12A2 ADAMTS16	1.00e-04	177	116	5	dc846d0feb94d4c289553cc3ac9dac81d10409cb
ToppCell	COVID-19-Heart-Lymph_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ANGPT2 PGM5 RASGRP3 TLL1 VAV3	1.00e-04	177	116	5	326fde0734ef0d7272693966d346ca479b9d8147
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANGPT2 PGM5 FBN1 TP63 RASGRP3	1.00e-04	177	116	5	c8a51e480b978dc0ded85583261f2c892e085be8
Disease	connective tissue disease (implicated_via_orthology)	FBN1 FBN2	3.97e-05	3	108	2	DOID:65 (implicated_via_orthology)
Disease	migraine disorder	GFRA2 OR4C3 FBN2 LRFN5 LRP1 LIMCH1 PRDM16 NOTCH4	5.22e-05	357	108	8	MONDO_0005277
Disease	scoliosis (is_implicated_in)	FBN1 FBN2	7.93e-05	4	108	2	DOID:0060249 (is_implicated_in)
Disease	Prostatic Neoplasms	CYP1B1 NCOA3 FBLN5 SRD5A1 IVNS1ABP SLC12A2 ITSN2 LRP2 VAV3 ZNF292	9.05e-05	616	108	10	C0033578
Disease	Malignant neoplasm of prostate	CYP1B1 NCOA3 FBLN5 SRD5A1 IVNS1ABP SLC12A2 ITSN2 LRP2 VAV3 ZNF292	9.05e-05	616	108	10	C0376358
Disease	rheumatoid arthritis (is_marker_for)	IL13 LRRK2 ESCO2 NOTCH4	1.22e-04	69	108	4	DOID:7148 (is_marker_for)
Disease	testicular cancer (implicated_via_orthology)	TP63 TP73	1.32e-04	5	108	2	DOID:2998 (implicated_via_orthology)
Disease	autosomal dominant polycystic kidney disease (biomarker_via_orthology)	ANGPT2 LRP2	2.75e-04	7	108	2	DOID:898 (biomarker_via_orthology)
Disease	hypokalemic periodic paralysis (implicated_via_orthology)	CACNA1S SCNN1B	3.66e-04	8	108	2	DOID:14452 (implicated_via_orthology)
Disease	Acute Confusional Migraine	LRP1 PRDM16	4.70e-04	9	108	2	C0521664
Disease	Status Migrainosus	LRP1 PRDM16	4.70e-04	9	108	2	C0338489
Disease	Abdominal Migraine	LRP1 PRDM16	4.70e-04	9	108	2	C0270858
Disease	Sick Headaches	LRP1 PRDM16	4.70e-04	9	108	2	C0700438
Disease	Cervical Migraine Syndrome	LRP1 PRDM16	4.70e-04	9	108	2	C0007852
Disease	Hemicrania migraine	LRP1 PRDM16	4.70e-04	9	108	2	C0018984
Disease	aortic aneurysm	FBN1 LRP1	5.86e-04	10	108	2	EFO_0001666
Disease	response to statin, myopathy	FBN2 SLC12A2	7.14e-04	11	108	2	EFO_0004145, GO_0036273
Disease	lymphocyte count	CACNA1S IL13 TRAF3 PPFIA1 RIPOR3 PPARD MED13L ERVW-1 ZBTB1 GFRA2 FBN1 HS6ST1 VWA2 HNRNPLL	9.14e-04	1464	108	14	EFO_0004587
Disease	Respiratory Depression	CACNA1S FBLN5	1.01e-03	13	108	2	C0235063
Disease	Respiratory Insufficiency	CACNA1S FBLN5	1.01e-03	13	108	2	C0035229
Disease	Migraine Disorders	LRP1 PRDM16	1.01e-03	13	108	2	C0149931
Disease	Respiratory Failure	CACNA1S FBLN5	1.01e-03	13	108	2	C1145670
Disease	Squamous cell carcinoma	CYP1B1 NCOA3 TP63 NOTCH4	1.14e-03	124	108	4	C0007137
Disease	response to lithium ion	GFRA2 SLC12A9 NOTCH4	1.15e-03	56	108	3	GO_0010226
Disease	Intellectual Disability	RTTN MED13L ZNF526 SUPT16H LRP2 MED13 ZNF292	1.31e-03	447	108	7	C3714756
Disease	psoriasis vulgaris	IL13 KCNH7 TP63	1.47e-03	61	108	3	EFO_1001494
Disease	uterine prolapse	FBN2 SLC12A2	1.54e-03	16	108	2	EFO_1001864
Disease	pelvic organ prolapse	GFRA2 FBN2 SLC12A2 TXNDC8	1.60e-03	136	108	4	EFO_0004710
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	MED13 ZNF292	1.74e-03	17	108	2	DOID:0060307 (is_implicated_in)
Disease	ischemia (implicated_via_orthology)	ANGPT2 SCNN1B	1.74e-03	17	108	2	DOID:326 (implicated_via_orthology)
Disease	Antimigraine preparation use measurement	LRP1 PRDM16	2.66e-03	21	108	2	EFO_0009939
Disease	axial length measurement	TP63 ADAMTS16 TIMELESS	2.87e-03	77	108	3	EFO_0005318
Disease	Primary microcephaly	RTTN ASPM	2.92e-03	22	108	2	C0431350
Disease	nephrosis (biomarker_via_orthology)	ANGPT2 LRP2	2.92e-03	22	108	2	DOID:2527 (biomarker_via_orthology)
Disease	Lung diseases	IL13 FBLN5 SCNN1B	2.97e-03	78	108	3	C0024115
Disease	Carcinomatosis	ID4 SPINT2 SLC12A2 TP63	3.08e-03	163	108	4	C0205699
Disease	Carcinoma, Spindle-Cell	ID4 SPINT2 SLC12A2 TP63	3.08e-03	163	108	4	C0205697
Disease	Undifferentiated carcinoma	ID4 SPINT2 SLC12A2 TP63	3.08e-03	163	108	4	C0205698
Disease	Anaplastic carcinoma	ID4 SPINT2 SLC12A2 TP63	3.08e-03	163	108	4	C0205696
Disease	lymphocyte percentage of leukocytes	CACNA1S TRAF3 MSL2 LIPA HS6ST1 PRDM16 NOTCH4 ZNF292	3.12e-03	665	108	8	EFO_0007993
Disease	Carcinoma	ID4 SPINT2 SLC12A2 TP63	3.15e-03	164	108	4	C0007097
Disease	nephrotic syndrome (implicated_via_orthology)	ITSN2 SCNN1B	3.48e-03	24	108	2	DOID:1184 (implicated_via_orthology)
Disease	Attention deficit hyperactivity disorder	MED13 ZNF292	3.48e-03	24	108	2	C1263846
Disease	lung squamous cell carcinoma (is_implicated_in)	CYP1B1 TP73	3.48e-03	24	108	2	DOID:3907 (is_implicated_in)
Disease	systemic scleroderma (is_implicated_in)	FBN1 NOTCH4	3.48e-03	24	108	2	DOID:418 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
NRTRCGTCNTGYMLS	BRINP3	456	Q76B58
RPYKCNDCNMAFVTS	CTCFL	311	Q8NI51
ALDQYLMEFNACRCG	C8A	486	P07357
CSYTFLLPEMDNCRS	ANGPT2	41	O15123
MAQLEGYCFSAALSC	ALG10B	1	Q5I7T1
NSLCGYQIRMESRAC	DHX29	656	Q7Z478
MAAIVNQSALCCYRS	ASPM	2766	Q8IZT6
CYRDLKFQVNMSFCN	ADAMTS16	896	Q8TE57
FCRMSYQDPAQLSCL	NFE2L1	551	Q14494
CLLQMYFFHSTGICE	OR6K2	96	Q8NGY2
SIISRFMYNSFGCAC	RAB41	46	Q5JT25
QAGNCRIMAYCDALS	RFWD3	446	Q6PCD5
CISRNEMGSVCCSYA	RECK	141	O95980
SHMQAYIRFCSCQLN	ITSN2	1296	Q9NZM3
KMNCSRVFNLFCLYG	HNRNPLL	346	Q8WVV9
FCNVVCRVGFQRMYS	PARP9	711	Q8IXQ6
FLVNNLAAGTMYDLC	LRFN5	471	Q96NI6
FFSNLMDSGRCNLCG	PGM5	366	Q15124
LCRDRSISYSGCMIQ	OR8D4	86	Q8NGM9
GNISLFACATQMCFF	OR10AG1	81	Q8NH19
DQYRCTCGFSAIMNR	MED13L	1156	Q71F56
SFLCCQSQLMFLASR	H2BC20P	166	Q6DN03
QCLACGKSFINYQFM	ZBTB33	551	Q86T24
VTSCISYRNFASCMG	IVNS1ABP	131	Q9Y6Y0
METNYLKRCFGNCLA	DYDC2	1	Q96IM9
IIYCNDGFCEMTGFS	KCNH7	41	Q9NS40
CMCTAGYSLRSGQQA	LRP1	1871	Q07954
MTYLCQIRAFCTGQE	EHBP1L1	1131	Q8N3D4
MYCAALESLINVSGC	IL13	76	P35225
SFQCGIMCLRRLNYD	PPFIA1	1016	Q13136
CNNVEVLMSGNVRCY	LRRK2	236	Q5S007
FVACGGLDNMCSIYN	GNB3	111	P16520
LFRDCNATTEFMCNN	LRP2	2776	P98164
QTCPSANYFDCRAMS	PSMA1	146	P25786
ALCLQCDMNDCYSRL	ID4	61	P47928
KGMCHVSRFAQYCSL	GPR83	141	Q9NYM4
LDCICRGCQNSYMAN	MSL2	491	Q9HCI7
SGCTLQEFMDCPYNL	HS6ST1	231	O60243
TILYNFMCNSSCVGG	TP73	251	O15350
MNFETSRCATLQYCP	TP63	1	Q9H3D4
TVLYNFMCNSSCVGG	TP63	301	Q9H3D4
DNYCALRATLFQAMS	OTULIN	126	Q96BN8
CSDDCGMKLAANRIY	CXXC1	391	Q9P0U4
LSCEQLGTYMCIATN	IGSF23	101	A1L1A6
SRFCQSLVMAAYSCQ	HYKK	311	A2RU49
SAGMIYCRCNFGLTA	KLHL28	556	Q9NXS3
TYRMLFCSCQDQACA	GFRA2	216	O00451
GSFCRNYFNMLDLLV	CACNA1S	861	Q13698
QHADCKNTMGSYRCL	FBN1	1376	P35555
QRIACQQMGYNCFSL	CPHXL2	141	A0A1W2PPK0
APRIGMDQCSCQFSY	FRMPD1	1326	Q5SYB0
YCMVSRLGCFNLFSK	DENND2C	591	Q68D51
TLRNCFMFGCFLSTD	ESCO2	556	Q56NI9
SCCEGYLCNRKSMTQ	LYPD5	206	Q6UWN5
VRLYQNMFCSAENCS	LYPD8	61	Q6UX82
SSYQCRLQALNFCMG	FOXS1	246	O43638
VANVMSAVCFGCRYS	CYP1B1	201	Q16678
RSCNCYMEALALVGA	HSDL1	16	Q3SXM5
LICRFGYQMDESNQC	FBLN5	111	Q9UBX5
PLLCAFRCMNTFGSY	FBN2	2261	P35556
AFSSRQAGIQMYLCN	COLGALT2	271	Q8IYK4
MNNQYIRREVFCCGT	FAM240B	1	A0A1B0GVZ2
LCTDCMDGYFSSLRN	CRELD2	176	Q6UXH1
YSIQACLRSCFQDHM	SCNN1B	381	P51168
NCNDCYMRSRSAGQP	LIMCH1	1066	Q9UPQ0
CSQLTTFYFGRNCMS	PRAMEF13	376	Q5VWM6
FCYDLLSAGDMATCQ	PLEKHF2	206	Q9H8W4
FLCNTSMENRCFYNS	HGD	136	Q93099
ENVNCYSSGMICRKF	OTOG	1026	Q6ZRI0
CVFICENNLYGMGTS	PDHA2	216	P29803
EGRTISYECCMAQLF	OR4C3	86	Q8NH37
HCYLGRCMFDLNFSA	RTTN	1496	Q86VV8
AYRCLNGSSESMCFL	ERVW-1	276	Q9UQF0
NSYRDCMLLGCLNSG	SLC6A6	321	P31641
LCAYMAAFNSINGNR	SFXN4	141	Q6P4A7
QYCRFQKCLALGMSH	PPARD	126	Q03181
SYMCQCRNGFVLHDN	TLL1	751	O43897
CGLTLNTNAELCQYM	NXPE2	231	Q96DL1
CSQLTTFYFGRNCMS	PRAMEF14	376	Q5SWL7
LCMYRNATGESCNEF	RASGRP3	56	Q8IV61
YIRVACSCDDQNLTM	PRDM16	171	Q9HAZ2
LGFYCDQNPVESSMC	NCOA3	571	Q9Y6Q9
FVGIRFCQECNNMLY	POLR2I	11	P36954
MCDSCYSGSLLNRHT	MPTX1	106	A8MV57
CSQLTTFYFGRNCMS	PRAMEF1	376	O95521
QEAQYRCTCGFSAVM	MED13	1116	Q9UHV7
ITCAMGIRFKSYCSN	SUPT16H	271	Q9Y5B9
YTGGSCQTLMDLCAQ	NOTCH4	836	Q99466
YMCCRGLFQSTSLNG	SLC28A2	611	O43868
SAMALTNCCGFYNNT	SLC28A2	641	O43868
ACCNNRTGMFLSSLF	TM4SF20	76	Q53R12
MALLCYNRGCGQRFD	CHORDC1	1	Q9UHD1
KELRYNECLMNFSCN	CNOT6L	436	Q96LI5
CSEFLENCYNRLMGS	TIMELESS	346	Q9UNS1
YCRNESRGCAEQLML	TRAF3	116	Q13114
GMCCYFAQDLRPEQS	ZNF724	76	A8MTY0
PYACNECGRAFSRMS	ZNF568	361	Q3ZCX4
YSCMAQNERGRASCE	SPEG	106	Q15772
YCIQCRLRDGASSMQ	RIPOR3	146	Q96MK2
DILQMNDLGTRCSFY	SPIDR	636	Q14159
FGTQNSNADMIYCRL	RYR3	1276	Q15413
CRGNKNSYRSEEACM	SPINT2	166	O43291
SCESSPCSYGLMNNF	SLC12A2	576	P55011
GLMFYLANVCGCAVS	SLC12A9	121	Q9BXP2
CTAFLSRQLQQGDMY	ZNF292	276	O60281
CMNEGSCVLQNGSYR	VWA2	721	Q5GFL6
YRDCIMLCCLNSGTS	SLC6A11	331	P48066
ARLSDSGNYTCMAAN	UNC5D	221	Q6UXZ4
FGCMSCNSLDYNLRV	UNC5D	696	Q6UXZ4
ICCYRSGFMSNLIFE	TXNDC8	96	Q6A555
MARYVCSICDQGNFR	ZBTB1	631	Q9Y2K1
AQNEGKAMSYQCSLC	ZNF507	116	Q8TCN5
LFCSYTCGQQRMLKT	ZNF507	251	Q8TCN5
CNECGKVFSYNSSLM	ZNF852	441	Q6ZMS4
QFMCSECGSLYNTLE	ZNF526	56	Q8TF50
IMFCTCNGYLQSRYL	SRD5A1	121	P18405
NFEENCCVMRYTTAG	STARD4	91	Q96DR4
MKIRYISALNCFGSC	WDR64	281	B1ANS9
SCKVCQMLLRGTFYQ	VAV3	526	Q9UKW4
CFLLCGFNERNLNMS	LIPA	261	P38571