Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone binding	TSPY4 TSPY3 TSPY10 TSPY9 TSPY2 TSPY8 TSPY1 KDM1B	3.94e-09	265	30	8	GO:0042393
GeneOntologyMolecularFunction	linoleoyl-CoA desaturase activity	FADS2 FADS1	2.18e-06	2	30	2	GO:0016213
GeneOntologyMolecularFunction	chromatin binding	TSPY4 TSPY3 TSPY10 TSPY9 TSPY2 TSPY8 TSPY1 KDM1B	9.62e-06	739	30	8	GO:0003682
GeneOntologyMolecularFunction	acyl-CoA desaturase activity	FADS2 FADS1	2.18e-05	5	30	2	GO:0016215
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	FADS2 FADS1	1.68e-04	13	30	2	GO:0016717
GeneOntologyMolecularFunction	hexosaminidase activity	HEXB CEMIP	2.93e-04	17	30	2	GO:0015929
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	FADS2 FADS1 KDM1B	3.02e-03	194	30	3	GO:0016705
GeneOntologyBiologicalProcess	gonadal mesoderm development	TSPY4 TSPY3 TSPY10 TSPY9 TSPY2 TSPY8 TSPY1	2.32e-19	9	30	7	GO:0007506
GeneOntologyBiologicalProcess	nucleosome assembly	TSPY4 TSPY3 TSPY10 TSPY9 TSPY2 TSPY8 TSPY1	3.87e-10	122	30	7	GO:0006334
GeneOntologyBiologicalProcess	nucleosome organization	TSPY4 TSPY3 TSPY10 TSPY9 TSPY2 TSPY8 TSPY1	1.13e-09	142	30	7	GO:0034728
GeneOntologyBiologicalProcess	mesoderm development	TSPY4 TSPY3 TSPY10 TSPY9 TSPY2 TSPY8 TSPY1	2.27e-09	157	30	7	GO:0007498
GeneOntologyBiologicalProcess	mesenchyme development	TSPY4 DAB2IP TSPY3 TSPY10 TSPY9 TSPY2 TSPY8 TSPY1	4.30e-08	372	30	8	GO:0060485
GeneOntologyBiologicalProcess	reproductive structure development	TSPY4 TSPY3 TSPY10 TSPY9 TSPY2 TSPY8 TSPY1 ALOX15B	5.38e-08	383	30	8	GO:0048608
GeneOntologyBiologicalProcess	protein-DNA complex assembly	TSPY4 TSPY3 TSPY10 TSPY9 TSPY2 TSPY8 TSPY1	5.52e-08	249	30	7	GO:0065004
GeneOntologyBiologicalProcess	reproductive system development	TSPY4 TSPY3 TSPY10 TSPY9 TSPY2 TSPY8 TSPY1 ALOX15B	5.95e-08	388	30	8	GO:0061458
GeneOntologyBiologicalProcess	gonad development	TSPY4 TSPY3 TSPY10 TSPY9 TSPY2 TSPY8 TSPY1	1.63e-07	292	30	7	GO:0008406
GeneOntologyBiologicalProcess	development of primary sexual characteristics	TSPY4 TSPY3 TSPY10 TSPY9 TSPY2 TSPY8 TSPY1	1.83e-07	297	30	7	GO:0045137
GeneOntologyBiologicalProcess	multicellular organismal reproductive process	TSPY4 TSPY3 HEXB TSPY10 TSPY9 TSPY2 DMXL2 TSPY8 TSPY1 KDM1B KALRN	4.60e-07	1194	30	11	GO:0048609
GeneOntologyBiologicalProcess	sex differentiation	TSPY4 TSPY3 TSPY10 TSPY9 TSPY2 TSPY8 TSPY1	5.77e-07	352	30	7	GO:0007548
GeneOntologyBiologicalProcess	developmental process involved in reproduction	TSPY4 TSPY3 HEXB TSPY10 TSPY9 TSPY2 DMXL2 TSPY8 TSPY1 KDM1B ALOX15B	6.44e-07	1235	30	11	GO:0003006
GeneOntologyBiologicalProcess	chromatin remodeling	TSPY4 TSPY3 USP7 TSPY10 TSPY9 TSPY2 TSPY8 TSPY1 KDM1B	6.89e-07	741	30	9	GO:0006338
GeneOntologyBiologicalProcess	gamete generation	TSPY4 TSPY3 HEXB TSPY10 TSPY9 TSPY2 DMXL2 TSPY8 TSPY1 KDM1B	7.19e-07	982	30	10	GO:0007276
GeneOntologyBiologicalProcess	chromatin organization	TSPY4 TSPY3 USP7 TSPY10 TSPY9 TSPY2 TSPY8 TSPY1 KDM1B	3.32e-06	896	30	9	GO:0006325
GeneOntologyBiologicalProcess	linoleic acid metabolic process	FADS2 FADS1 ALOX15B	4.82e-06	23	30	3	GO:0043651
GeneOntologyBiologicalProcess	spermatogenesis	TSPY4 TSPY3 TSPY10 TSPY9 TSPY2 DMXL2 TSPY8 TSPY1	7.98e-06	744	30	8	GO:0007283
GeneOntologyBiologicalProcess	protein-DNA complex organization	TSPY4 TSPY3 USP7 TSPY10 TSPY9 TSPY2 TSPY8 TSPY1 KDM1B	8.05e-06	999	30	9	GO:0071824
GeneOntologyBiologicalProcess	male gamete generation	TSPY4 TSPY3 TSPY10 TSPY9 TSPY2 DMXL2 TSPY8 TSPY1	9.50e-06	762	30	8	GO:0048232
GeneOntologyBiologicalProcess	sexual reproduction	TSPY4 TSPY3 HEXB TSPY10 TSPY9 TSPY2 DMXL2 TSPY8 TSPY1 KDM1B	9.72e-06	1312	30	10	GO:0019953
GeneOntologyBiologicalProcess	unsaturated fatty acid biosynthetic process	FADS2 FADS1 ALOX15B	7.31e-05	56	30	3	GO:0006636
GeneOntologyBiologicalProcess	alpha-linolenic acid metabolic process	FADS2 FADS1	9.14e-05	10	30	2	GO:0036109
GeneOntologyBiologicalProcess	hyaluronan catabolic process	HEXB CEMIP	3.08e-04	18	30	2	GO:0030214
GeneOntologyBiologicalProcess	long-chain fatty acid metabolic process	FADS2 FADS1 ALOX15B	7.65e-04	124	30	3	GO:0001676
GeneOntologyBiologicalProcess	long-chain fatty acid biosynthetic process	FADS1 ALOX15B	8.10e-04	29	30	2	GO:0042759
GeneOntologyBiologicalProcess	unsaturated fatty acid metabolic process	FADS2 FADS1 ALOX15B	8.38e-04	128	30	3	GO:0033559
GeneOntologyBiologicalProcess	glycosaminoglycan catabolic process	HEXB CEMIP	9.87e-04	32	30	2	GO:0006027
GeneOntologyBiologicalProcess	aminoglycan catabolic process	HEXB CEMIP	1.39e-03	38	30	2	GO:0006026
GeneOntologyBiologicalProcess	hyaluronan metabolic process	HEXB CEMIP	1.54e-03	40	30	2	GO:0030212
GeneOntologyCellularComponent	chromatin	TSPY4 TSPY3 TSPY10 TSPY9 TSPY2 RFX6 TSPY8 TSPY1 KDM1B	1.60e-04	1480	30	9	GO:0000785
GeneOntologyCellularComponent	aggresome	TRIM73 TRIM74	1.50e-03	40	30	2	GO:0016235
MousePheno	hypochlorhydria	TRIM73 TRIM74	4.07e-05	7	20	2	MP:0008001
MousePheno	decreased prostaglandin level	FADS2 FADS1	1.50e-04	13	20	2	MP:0009815
MousePheno	abnormal pituitary secretion	KALRN NPFFR1	1.75e-04	14	20	2	MP:0001746
MousePheno	increased stomach pH	TRIM73 TRIM74	2.61e-04	17	20	2	MP:0008006
MousePheno	abnormal stomach pH	TRIM73 TRIM74	3.28e-04	19	20	2	MP:0008004
MousePheno	abnormal pituitary gland physiology	KALRN NPFFR1	6.19e-04	26	20	2	MP:0005646
MousePheno	abnormal gastric parietal cell morphology	TRIM73 TRIM74	6.19e-04	26	20	2	MP:0004139
MousePheno	abnormal prostaglandin level	FADS2 FADS1	6.19e-04	26	20	2	MP:0009811
Domain	NAP	TSPY4 TSPY10 TSPY2 TSPY8	8.14e-09	17	27	4	PF00956
Domain	NAP_family	TSPY4 TSPY10 TSPY2 TSPY8	8.14e-09	17	27	4	IPR002164
Domain	Fatty_acid_desaturase	FADS2 FADS1	6.03e-06	3	27	2	IPR012171
Domain	FA_desaturase_dom	FADS2 FADS1	5.61e-05	8	27	2	IPR005804
Domain	FA_desaturase	FADS2 FADS1	5.61e-05	8	27	2	PF00487
Domain	CYTOCHROME_B5_2	FADS2 FADS1	1.55e-04	13	27	2	PS50255
Domain	CYTOCHROME_B5_1	FADS2 FADS1	1.55e-04	13	27	2	PS00191
Domain	Cyt-b5	FADS2 FADS1	1.81e-04	14	27	2	PF00173
Domain	Cyt_B5-like_heme/steroid-bd	FADS2 FADS1	1.81e-04	14	27	2	IPR001199
Domain	Cyt-b5	FADS2 FADS1	1.81e-04	14	27	2	SM01117
Domain	-	FADS2 FADS1	1.81e-04	14	27	2	3.10.120.10
Domain	Znf-RING_LisH	TRIM73 TRIM74	1.10e-03	34	27	2	IPR027370
Domain	zf-RING_UBOX	TRIM73 TRIM74	1.10e-03	34	27	2	PF13445
Domain	BBOX	TRIM73 TRIM74	4.45e-03	69	27	2	SM00336
Domain	-	TRIM73 TRIM74	4.70e-03	71	27	2	4.10.45.10
Domain	zf-B_box	TRIM73 TRIM74	4.83e-03	72	27	2	PF00643
Domain	ZF_BBOX	TRIM73 TRIM74	5.93e-03	80	27	2	PS50119
Domain	Znf_B-box	TRIM73 TRIM74	6.08e-03	81	27	2	IPR000315
Domain	PH	ASAP3 DAB2IP KALRN	7.33e-03	278	27	3	SM00233
Domain	PH_DOMAIN	ASAP3 DAB2IP KALRN	7.40e-03	279	27	3	PS50003
Domain	PH_domain	ASAP3 DAB2IP KALRN	7.47e-03	280	27	3	IPR001849
Pathway	WP_OXYLIPINS_PATHWAYS	FADS2 FADS1 ALOX15B	5.65e-06	24	21	3	MM17249
Pathway	WP_SEBALEIC_ACID_FORMATION_AND_METABOLISM	FADS2 FADS1	2.11e-05	5	21	2	M48057
Pathway	WP_LINOLEIC_ACID_METABOLISM_AFFECTED_BY_SARSCOV2	FADS2 FADS1	3.16e-05	6	21	2	M42575
Pathway	WP_METABOLISM_OF_ALPHALINOLENIC_ACID	FADS2 FADS1	3.16e-05	6	21	2	M39844
Pathway	REACTOME_LINOLEIC_ACID_LA_METABOLISM	FADS2 FADS1	5.89e-05	8	21	2	MM14822
Pathway	REACTOME_LINOLEIC_ACID_LA_METABOLISM	FADS2 FADS1	5.89e-05	8	21	2	M27115
Pathway	WP_OMEGA6FATTY_ACIDS_IN_SENESCENCE	FADS2 FADS1 ALOX15B	7.92e-05	57	21	3	M48332
Pathway	WP_ELONGATION_OF_VERY_LONG_CHAIN_FATTY_ACIDS	FADS2 FADS1	1.38e-04	12	21	2	MM17077
Pathway	REACTOME_ALPHA_LINOLENIC_OMEGA3_AND_LINOLEIC_OMEGA6_ACID_METABOLISM	FADS2 FADS1	1.63e-04	13	21	2	MM14821
Pathway	REACTOME_ALPHA_LINOLENIC_OMEGA3_AND_LINOLEIC_OMEGA6_ACID_METABOLISM	FADS2 FADS1	1.63e-04	13	21	2	M27114
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	FADS2 FADS1	1.90e-04	14	21	2	MM15840
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	FADS2 FADS1	1.90e-04	14	21	2	M39780
Pathway	WP_OMEGA3_OMEGA6_FATTY_ACID_SYNTHESIS	FADS2 FADS1	2.19e-04	15	21	2	M39789
Pathway	WP_OMEGA3_OMEGA6_FATTY_ACID_SYNTHESIS	FADS2 FADS1	2.50e-04	16	21	2	MM15813
Pathway	REACTOME_HYALURONAN_METABOLISM	HEXB CEMIP	2.84e-04	17	21	2	M666
Pathway	REACTOME_HYALURONAN_METABOLISM	HEXB CEMIP	2.84e-04	17	21	2	MM14864
Pathway	KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS	FADS2 FADS1	4.80e-04	22	21	2	M11673
Pathway	WP_SELENIUM_MICRONUTRIENT_NETWORK	FADS2 FADS1	5.25e-04	23	21	2	MM15979
Pathway	REACTOME_FATTY_ACID_METABOLISM	FADS2 FADS1 ALOX15B	1.95e-03	170	21	3	MM15573
Pathway	REACTOME_FATTY_ACID_METABOLISM	FADS2 FADS1 ALOX15B	2.16e-03	176	21	3	M27854
Pathway	WP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS	FADS2 FADS1	2.19e-03	47	21	2	M39853
Pathway	WP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS	FADS2 FADS1	2.68e-03	52	21	2	MM15920
Pubmed	TSPY, the candidate gonadoblastoma gene on the human Y chromosome, has a widely expressed homologue on the X - implications for Y chromosome evolution.	TSPY9 TSPY1	7.69e-07	2	31	2	15241014
Pubmed	FADS1-FADS2 genetic polymorphisms are associated with fatty acid metabolism through changes in DNA methylation and gene expression.	FADS2 FADS1	7.69e-07	2	31	2	30157936
Pubmed	FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer.	FADS2 FADS1	7.69e-07	2	31	2	38926633
Pubmed	Impact of FADS genotype on polyunsaturated fatty acid content in human milk extracellular vesicles: A genetic association study.	FADS2 FADS1	7.69e-07	2	31	2	38566550
Pubmed	An Exceptional Gene: Evolution of the TSPY Gene Family in Humans and Other Great Apes.	TSPY9 TSPY1	7.69e-07	2	31	2	24710137
Pubmed	TSPY-related sequences represent a microheterogeneous gene family organized as constitutive elements in DYZ5 tandem repeat units on the human Y chromosome.	TSPY9 TSPY1	7.69e-07	2	31	2	8244388
Pubmed	A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids.	FADS2 FADS1	7.69e-07	2	31	2	22619218
Pubmed	Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids.	FADS2 FADS1	7.69e-07	2	31	2	16670158
Pubmed	Limited Evidence for Selection at the FADS Locus in Native American Populations.	FADS2 FADS1	7.69e-07	2	31	2	32145021
Pubmed	Differences in erythrocyte phospholipid membrane long-chain polyunsaturated fatty acids and the prevalence of fatty acid desaturase genotype among African Americans and European Americans.	FADS2 FADS1	7.69e-07	2	31	2	33310680
Pubmed	Mendelian randomization shows sex-specific associations between long-chain PUFA-related genotypes and cognitive performance in Danish schoolchildren.	FADS2 FADS1	7.69e-07	2	31	2	28515069
Pubmed	Erythrocyte polyunsaturated fatty acid composition is associated with depression and FADS genotype in Caucasians.	FADS2 FADS1	7.69e-07	2	31	2	28552045
Pubmed	Dietary n-3 and n-6 polyunsaturated fatty acids, the FADS gene, and the risk of gastric cancer in a Korean population.	FADS2 FADS1	7.69e-07	2	31	2	29491470
Pubmed	Association of fatty acid desaturase genes with attention-deficit/hyperactivity disorder.	FADS2 FADS1	7.69e-07	2	31	2	16893529
Pubmed	Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation.	FADS2 FADS1	7.69e-07	2	31	2	18936223
Pubmed	Structure and function of TSPY, the Y-chromosome gene coding for the "testis-specific protein".	TSPY9 TSPY1	7.69e-07	2	31	2	9678360
Pubmed	Battle of the sexes: contrasting roles of testis-specific protein Y-encoded (TSPY) and TSPX in human oncogenesis.	TSPY9 TSPY1	7.69e-07	2	31	2	29974883
Pubmed	FADS1 FADS2 gene cluster, PUFA intake and blood lipids in children: results from the GINIplus and LISAplus studies.	FADS2 FADS1	7.69e-07	2	31	2	22629455
Pubmed	A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle.	FADS2 FADS1	7.69e-07	2	31	2	20364269
Pubmed	Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease.	FADS2 FADS1	7.69e-07	2	31	2	27004414
Pubmed	FADS Polymorphism, Omega-3 Fatty Acids and Diabetes Risk: A Systematic Review.	FADS2 FADS1	7.69e-07	2	31	2	29899246
Pubmed	Dietary pattern regulates fatty acid desaturase 1 gene expression in Indian pregnant women to spare overall long chain polyunsaturated fatty acids levels.	FADS2 FADS1	7.69e-07	2	31	2	30511301
Pubmed	Genetic variants of the FADS1 FADS2 gene cluster as related to essential fatty acid metabolism.	FADS2 FADS1	7.69e-07	2	31	2	19809313
Pubmed	Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life.	FADS2 FADS1	7.69e-07	2	31	2	20948998
Pubmed	Docosahexaenoic acid (DHA) supplementation in pregnancy differentially modulates arachidonic acid and DHA status across FADS genotypes in pregnancy.	FADS2 FADS1	7.69e-07	2	31	2	25500337
Pubmed	FADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes.	FADS2 FADS1	7.69e-07	2	31	2	28555039
Pubmed	Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans.	FADS2 FADS1	7.69e-07	2	31	2	24962583
Pubmed	Influence of FADS polymorphisms on tracking of serum glycerophospholipid fatty acid concentrations and percentage composition in children.	FADS2 FADS1	7.69e-07	2	31	2	21818279
Pubmed	Vitamin B-6 restriction impairs fatty acid synthesis in cultured human hepatoma (HepG2) cells.	FADS2 FADS1	7.69e-07	2	31	2	23211517
Pubmed	Maternal polymorphisms in the FADS1 and FADS2 genes modify the association between PUFA ingestion and plasma concentrations of omega-3 polyunsaturated fatty acids.	FADS2 FADS1	7.69e-07	2	31	2	31568926
Pubmed	Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios.	FADS2 FADS1	7.69e-07	2	31	2	20427696
Pubmed	Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster.	FADS2 FADS1	7.69e-07	2	31	2	28957329
Pubmed	Do FADS genotypes enhance our knowledge about fatty acid related phenotypes?	FADS2 FADS1	7.69e-07	2	31	2	19948371
Pubmed	The role of fatty acid desaturase (FADS) genes in oleic acid metabolism: FADS1 Δ7 desaturates 11-20:1 to 7,11-20:2.	FADS2 FADS1	7.69e-07	2	31	2	29413358
Pubmed	Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis.	FADS2 FADS1	7.69e-07	2	31	2	32186652
Pubmed	Associations of umbilical cord fatty acid profiles and desaturase enzyme indices with birth weight for gestational age in Japanese infants.	FADS2 FADS1	7.69e-07	2	31	2	33387849
Pubmed	FADS gene cluster polymorphisms: important modulators of fatty acid levels and their impact on atopic diseases.	FADS2 FADS1	7.69e-07	2	31	2	19776639
Pubmed	Polyunsaturated fatty acid regulation of adipocyte FADS1 and FADS2 expression and function.	FADS2 FADS1	7.69e-07	2	31	2	25755223
Pubmed	Insertion-deletions in a FADS2 intron 1 conserved regulatory locus control expression of fatty acid desaturases 1 and 2 and modulate response to simvastatin.	FADS2 FADS1	7.69e-07	2	31	2	22748975
Pubmed	The role of FADS1/2 polymorphisms on cardiometabolic markers and fatty acid profiles in young adults consuming fish oil supplements.	FADS2 FADS1	7.69e-07	2	31	2	24936800
Pubmed	Early nutrition in combination with polymorphisms in fatty acid desaturase gene cluster modulate fatty acid composition of cheek cells' glycerophospholipids in school-age children.	FADS2 FADS1	7.69e-07	2	31	2	31638497
Pubmed	Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition.	FADS2 FADS1	7.69e-07	2	31	2	23221573
Pubmed	Long-chain polyunsaturated fatty acid status in obesity: a systematic review and meta-analysis.	FADS2 FADS1	7.69e-07	2	31	2	25828602
Pubmed	FADS gene variants modulate the effect of dietary fatty acid intake on allergic diseases in children.	FADS2 FADS1	7.69e-07	2	31	2	21793953
Pubmed	Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement.	FADS2 FADS1	7.69e-07	2	31	2	23160180
Pubmed	Interaction of fatty acid genotype and diet on changes in colonic fatty acids in a Mediterranean diet intervention study.	FADS2 FADS1	7.69e-07	2	31	2	24022589
Pubmed	FADS1-FADS2 gene cluster confers risk to polycystic ovary syndrome.	FADS2 FADS1	7.69e-07	2	31	2	26879377
Pubmed	Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.	FADS2 FADS1	7.69e-07	2	31	2	36864135
Pubmed	Lack of association of SNPs from the FADS1-FADS2 gene cluster with major depression or suicidal behavior.	FADS2 FADS1	7.69e-07	2	31	2	26513616
Pubmed	FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk.	FADS2 FADS1	7.69e-07	2	31	2	20335541
Pubmed	Association of two polymorphisms in the FADS1/FADS2 gene cluster and the risk of coronary artery disease and ischemic stroke.	FADS2 FADS1	7.69e-07	2	31	2	26261632
Pubmed	Delta-5 and delta-6 desaturases: crucial enzymes in polyunsaturated fatty acid-related pathways with pleiotropic influences in health and disease.	FADS2 FADS1	7.69e-07	2	31	2	25038994
Pubmed	Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study.	FADS2 FADS1	7.69e-07	2	31	2	26474818
Pubmed	FADS1 and FADS2 Gene Polymorphisms Modulate the Relationship of Omega-3 and Omega-6 Fatty Acid Plasma Concentrations in Gestational Weight Gain: A NISAMI Cohort Study.	FADS2 FADS1	7.69e-07	2	31	2	35268031
Pubmed	Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study.	FADS2 FADS1	7.69e-07	2	31	2	20691134
Pubmed	Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study.	FADS2 FADS1	7.69e-07	2	31	2	20980488
Pubmed	Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome.	FADS2 FADS1	7.69e-07	2	31	2	21733300
Pubmed	FADS2 polymorphisms are associated with plasma arachidonic acid and estimated desaturase-5 activity in a cross-sectional study.	FADS2 FADS1	7.69e-07	2	31	2	33011673
Pubmed	Genetically determined variation in polyunsaturated fatty acid metabolism may result in different dietary requirements.	FADS2 FADS1	7.69e-07	2	31	2	18626191
Pubmed	Role of FADS1 and FADS2 polymorphisms in polyunsaturated fatty acid metabolism.	FADS2 FADS1	7.69e-07	2	31	2	20045144
Pubmed	Polymorphisms in FADS1 and FADS2 alter desaturase activity in young Caucasian and Asian adults.	FADS2 FADS1	7.69e-07	2	31	2	21414826
Pubmed	Increasing dietary EPA and DHA influence estimated fatty acid desaturase activity in systemic organs which is reflected in the red blood cell in mice.	FADS2 FADS1	7.69e-07	2	31	2	28697636
Pubmed	FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease.	FADS2 FADS1	7.69e-07	2	31	2	18842780
Pubmed	Associations between Fatty Acid Intake and Status, Desaturase Activities, and FADS Gene Polymorphism in Centrally Obese Postmenopausal Polish Women.	FADS2 FADS1	7.69e-07	2	31	2	30103441
Pubmed	Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio.	FADS2 FADS1	7.69e-07	2	31	2	27613800
Pubmed	Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study.	FADS2 FADS1	7.69e-07	2	31	2	20484448
Pubmed	Decreased liver fatty acid delta-6 and delta-5 desaturase activity in obese patients.	FADS2 FADS1	7.69e-07	2	31	2	19875987
Pubmed	High Frequency of Ancestral Haplotype A of Fatty Acid Desaturase Genes in the Yakut Population.	FADS2 FADS1	7.69e-07	2	31	2	38860387
Pubmed	FADS1 and FADS2 polymorphism are associated with changes in fatty acid concentrations after calorie-restricted Central European and Mediterranean diets.	FADS2 FADS1	7.69e-07	2	31	2	31567872
Pubmed	Reduction of Arachidonate Is Associated With Increase in B-Cell Activation Marker in Infants: A Randomized Trial.	FADS2 FADS1	7.69e-07	2	31	2	27276431
Pubmed	Carrying minor allele of FADS1 and haplotype of FADS1 and FADS2 increased the risk of metabolic syndrome and moderate but not low fat diets lowered the risk in two Korean cohorts.	FADS2 FADS1	7.69e-07	2	31	2	29779171
Pubmed	Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children.	FADS2 FADS1	7.69e-07	2	31	2	21106917
Pubmed	SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease.	FADS2 FADS1	7.69e-07	2	31	2	18320251
Pubmed	Polymorphisms of rs174616 in the FADS1-FADS2 gene cluster is associated with a reduced risk of type 2 diabetes mellitus in northern Han Chinese people.	FADS2 FADS1	7.69e-07	2	31	2	25981324
Pubmed	Brain tissue- and cell type-specific eQTL Mendelian randomization reveals efficacy of FADS1 and FADS2 on cognitive function.	FADS2 FADS1	7.69e-07	2	31	2	38316767
Pubmed	Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 ( FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes.	FADS2 FADS1	7.69e-07	2	31	2	18479586
Pubmed	Adiposity Associated Plasma Linoleic Acid is Related to Demographic, Metabolic Health and Haplotypes of FADS1/2 Genes in Irish Adults.	FADS2 FADS1	7.69e-07	2	31	2	29388724
Pubmed	GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice.	FADS2 FADS1	7.69e-07	2	31	2	36806390
Pubmed	Placental expression of Fatty Acid Desaturases 1, 2 and 3 in selected pregnancy pathologies.	FADS2 FADS1	2.31e-06	3	31	2	36652541
Pubmed	A case-control study between the gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and coronary artery disease in a Chinese Han population.	FADS2 FADS1	2.31e-06	3	31	2	21917437
Pubmed	Association of polyunsaturated fatty acids in breast milk with fatty acid desaturase gene polymorphisms among Chinese lactating mothers.	FADS2 FADS1	2.31e-06	3	31	2	27269715
Pubmed	Genetic variation in lipid desaturases and its impact on the development of human disease.	FADS2 FADS1	2.31e-06	3	31	2	20565855
Pubmed	A case-control study between gene polymorphisms of polyunsaturated fatty acid metabolic rate-limiting enzymes and acute coronary syndrome in Chinese Han population.	FADS2 FADS1	2.31e-06	3	31	2	23555103
Pubmed	[A case-control study between gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and paranoid schizophrenia of Han ethnicity in Jilin Province].	FADS2 FADS1	2.31e-06	3	31	2	21560298
Pubmed	Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality.	FADS2 FADS1	2.31e-06	3	31	2	33904180
Pubmed	Variation in the FADS1/2 gene cluster alters plasma n-6 PUFA and is weakly associated with hsCRP levels in healthy young adults.	FADS2 FADS1	2.31e-06	3	31	2	23867726
Pubmed	Identification of genes and pathways involved in the synthesis of Mead acid (20:3n-9), an indicator of essential fatty acid deficiency.	FADS2 FADS1	2.31e-06	3	31	2	24184513
Pubmed	Bivariate genome-wide association study suggests fatty acid desaturase genes and cadherin DCHS2 for variation of both compressive strength index and appendicular lean mass in males.	FADS2 FADS1	2.31e-06	3	31	2	22960237
Pubmed	Gene expression of desaturase (FADS1 and FADS2) and Elongase (ELOVL5) enzymes in peripheral blood: association with polyunsaturated fatty acid levels and atopic eczema in 4-year-old children.	FADS2 FADS1	2.31e-06	3	31	2	24167612
Pubmed	Umbilical cord PUFA are determined by maternal and child fatty acid desaturase (FADS) genetic variants in the Avon Longitudinal Study of Parents and Children (ALSPAC).	FADS2 FADS1	2.31e-06	3	31	2	22877655
Pubmed	Regulation of desaturase expression in HL60 cells.	FADS2 FADS1	2.31e-06	3	31	2	17852835
Pubmed	Flavonoids as putative modulators of Δ4-, Δ5-, and Δ6-desaturases: Studies in cultured hepatocytes, myocytes, and adipocytes.	FADS2 FADS1	2.31e-06	3	31	2	30365230
Pubmed	Gene structure variation in segmental duplication block C of human chromosome 7q 11.23 during primate evolution.	TRIM73 TRIM74	2.31e-06	3	31	2	26196062
Pubmed	FADS gene polymorphisms in Koreans: association with ω6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease.	FADS2 FADS1	2.31e-06	3	31	2	21040914
Pubmed	Association of fatty acid desaturase gene polymorphisms with blood lipid essential fatty acids and perinatal depression among Canadian women: a pilot study.	FADS2 FADS1	2.31e-06	3	31	2	20395685
Pubmed	Genetic variants in desaturase gene, erythrocyte fatty acids, and risk for type 2 diabetes in Chinese Hans.	FADS2 FADS1	2.31e-06	3	31	2	24985009
Pubmed	TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells.	TRIM73 TRIM74	2.31e-06	3	31	2	22872646
Pubmed	Association Between Genetic Variants in FADS1-FADS2 and ELOVL2 and Obesity, Lipid Traits, and Fatty Acids in Tunisian Population.	FADS2 FADS1	2.31e-06	3	31	2	32584610
Pubmed	cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family.	FADS2 FADS1	2.31e-06	3	31	2	10860662
Pubmed	Fatty acid profile and estimated desaturase activities in whole blood are associated with metabolic health.	FADS2 FADS1	2.31e-06	3	31	2	32438926
Interaction	TSPY8 interactions	TSPY3 TSPY2 TSPY8	2.68e-09	3	29	3	int:TSPY8
Interaction	LY75 interactions	USP7 LY75	5.99e-06	3	29	2	int:LY75
Interaction	HCRTR2 interactions	USP7 DMXL2 FADS1	2.36e-05	39	29	3	int:HCRTR2
Interaction	TSPY3 interactions	TSPY3 TSPY8	2.99e-05	6	29	2	int:TSPY3
Interaction	TSPY1 interactions	USP7 TSPY1	4.18e-05	7	29	2	int:TSPY1
Interaction	TSPY2 interactions	TSPY2 TSPY8	1.54e-04	13	29	2	int:TSPY2
Interaction	SLC22A4 interactions	PIGW DMXL2 TMEM120A FADS1	1.57e-04	192	29	4	int:SLC22A4
Cytoband	Yp11.2	TSPY4 TSPY3 TSPY10 TSPY9 TSPY2 TSPY8 TSPY1	3.03e-13	94	31	7	Yp11.2
Cytoband	Ensembl 112 genes in cytogenetic band chrYp11	TSPY4 TSPY3 TSPY10 TSPY9 TSPY2 TSPY8 TSPY1	8.50e-12	150	31	7	chrYp11
Cytoband	7q11.23	TMEM120A TRIM73 TRIM74	3.94e-05	97	31	3	7q11.23
Cytoband	Ensembl 112 genes in cytogenetic band chr7q11	TMEM120A TRIM73 TRIM74	8.09e-04	271	31	3	chr7q11
GeneFamily	Fatty acid desaturases	FADS2 FADS1	2.92e-05	8	19	2	553
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM73 TRIM74	4.41e-03	95	19	2	59
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Poorly_Differentiated_or_Epithelioid_Leiomyosarcoma-7\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	TSPY4 TSPY10 TSPY9 TSPY2 TSPY8	7.56e-09	99	31	5	4f0346fe85ba006d1ab28a61624568522ffe5cb4
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RFX6 KALRN ALOX15B CEMIP	4.39e-06	159	31	4	4000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RFX6 KALRN ALOX15B CEMIP	4.39e-06	159	31	4	7619d0d49738dd08daf01b42664691a5323aa793
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RFX6 KALRN ALOX15B CEMIP	5.20e-06	166	31	4	5e3b998d740b24f790fad37350d704ca0ea10b77
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l22\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RFX6 KALRN ALOX15B CEMIP	5.20e-06	166	31	4	bcdaab49bde5beba750b76fdcc3781a3c12c4fff
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Rectal_Adenocarcinoma-5\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CAPN9 TSPY10 TSPY2	8.89e-05	125	31	3	c82b4bddc98b2a2d2ee00c1392df86f9735c0623
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Rectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CAPN9 TSPY10 TSPY2	1.19e-04	138	31	3	e1e936ff4080bda2810c5fd1154a706359f377a5
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	HEXB DMXL2 ALOX15B	1.47e-04	148	31	3	fd0d8386b94adb1bdc993fbb44d2d87852bfd7f0
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN9 ABCA9 CEMIP	1.52e-04	150	31	3	1270f33f9d7e46e55adf1a96e8beee858b95589d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN9 ABCA9 CEMIP	1.52e-04	150	31	3	156118ce1d69522624196410cba18b8354cd0bb4
ToppCell	droplet-Lung-1m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_l12\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HEXB FADS1 ABCA9	2.20e-04	170	31	3	0272eb1487c2545d4aa06f5d1cd77f823e1441e9
ToppCell	droplet-Lung-1m-Hematologic-myeloid-interstitial_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HEXB FADS1 ABCA9	2.20e-04	170	31	3	f664c7559e383b37845c123e41a3be316d869ba0
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_4\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ASAP3 DAB2IP ALOX15B	2.32e-04	173	31	3	ef8d720b99470fe1953661f6e66bc0366266bdb6
ToppCell	metastatic_Lymph_Node-Endothelial_cells-Lymphatic_ECs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	KALRN ABCA9 CEMIP	2.36e-04	174	31	3	d551bc29afef071adf4c9bb80345352ec33441d8
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC3-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LY75 NPFFR1 ALOX15B	2.48e-04	177	31	3	d34b086a5931d7f1737a504952d51c47693e91a8
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HEXB DMXL2 LY75	2.69e-04	182	31	3	57f8b8d7b132f3ad6f2b1e79c3812fe938657d2c
ToppCell	facs-Large_Intestine-Distal-24m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN9 HEXB FADS2	2.82e-04	185	31	3	2ecc4b76b3645b65c226c2298bff307cc6479172
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN9 HEXB FADS2	2.82e-04	185	31	3	e29079ef09aee62c3e9756341db4e59ca9dbf7ac
ToppCell	megakaryocytic-CD34+_Megakaryoblast\|World / Lineage and Cell class	FADS2 FADS1 KALRN	3.05e-04	190	31	3	1d19b2bd55789bf13e1386332f46c605973d6f8e
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FADS2 FADS1 ALOX15B	3.10e-04	191	31	3	6cb2c107bc674aa173b4009f320a1687a76f3979
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.1.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FADS2 FADS1 ALOX15B	3.20e-04	193	31	3	ba484fa1f290a92ae02475a4c468b4ac840c133e
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_10\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FADS2 LY75 NPFFR1	3.20e-04	193	31	3	a2194012dfa0174c6160900625c44e0fd04c50e7
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_10\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FADS2 LY75 NPFFR1	3.20e-04	193	31	3	7426a30ed01e5c8376b3e0ebe0f1057cfee88340
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.4.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FADS2 FADS1 ALOX15B	3.20e-04	193	31	3	043dd0fc2f93e0bd1ca34ac3e196622b3e91df0f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FADS2 KALRN ABCA9	3.30e-04	195	31	3	cad6563cc51d212554152c727fc2c249c6a07e4d
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FADS2 FADS1 ALOX15B	3.30e-04	195	31	3	d9694db6bf239636d1335016878c98f6ee2eb0eb
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FADS2 FADS1 ALOX15B	3.30e-04	195	31	3	37aa6e4123d37de4de42ca68d3020f2a7686ce02
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FADS2 KALRN ABCA9	3.30e-04	195	31	3	783bfa8110161cbd6def50ce849cae676c39c458
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.1.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FADS2 FADS1 ALOX15B	3.34e-04	196	31	3	b1abecc0aafc09ca70a5fde624f2a998c4aa3341
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	HEXB DMXL2 ALOX15B	3.34e-04	196	31	3	28e9e191361966df3a9bd48450090577aa72a999
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN ABCA9 CEMIP	3.40e-04	197	31	3	ae0435f4b4a9cdedb1c201fc56921048390097bf
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN ABCA9 CEMIP	3.40e-04	197	31	3	37f6b6f2809b952382eaebb642b0aad6371f4251
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FADS2 FADS1 ALOX15B	3.40e-04	197	31	3	d2a4d7e92e91bcc47a7657da2e5c8a3ad7eb08ad
ToppCell	BAL-Severe-Myeloid-cDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FADS2 LY75 NPFFR1	3.50e-04	199	31	3	d017848256704ae7237030868b143c3f0842a9c3
ToppCell	BAL-Severe-Myeloid-cDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	FADS2 LY75 NPFFR1	3.50e-04	199	31	3	0b20ae65b9340d844e271acda9e116d98fc1cc69
ToppCell	BAL-Severe-Myeloid-cDC-cDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FADS2 LY75 NPFFR1	3.50e-04	199	31	3	9a0e853693e572c63b135f937b2cffd4dd4026fb
ToppCell	BAL-Severe-Myeloid-cDC-cDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	FADS2 LY75 NPFFR1	3.50e-04	199	31	3	bb9e7418468b88cdfaa78788d062362794ea8230
ToppCell	Severe_COVID-19-Myeloid-cDC\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	FADS2 LY75 NPFFR1	3.50e-04	199	31	3	9132c1929d3445fcca49f76f010ca37adeb70315
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FADS2 FADS1 ALOX15B	3.50e-04	199	31	3	2dc33804f6691d7c9682e6c9b885e945fb97fc36
Disease	level of Phosphatidylinositol (16:0_18:1) in blood serum	USP7 FADS2 FADS1	1.18e-07	12	25	3	OBA_2045152
Disease	Palmitoyl-arachidonoyl-glycerol (16:0/20:4) [2] measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0022103
Disease	Sphingomyelin (d18:2/14:0, d18:1/14:1) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0022114
Disease	phosphatidylcholine acyl-alkyl C38:5 measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0801299
Disease	phosphatidylcholine acyl-alkyl C36:4 measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0801292
Disease	phosphatidylcholine acyl-alkyl C36:2 measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0801290
Disease	phosphatidylcholine diacyl C38:5 measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0801267
Disease	phosphatidylcholine diacyl C38:4 measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0801266
Disease	phosphatidylcholine diacyl C36:4 measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0801260
Disease	phosphatidylcholine diacyl C40:6 measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0801274
Disease	2-arachidonoylglycerol (20:4) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0800182
Disease	phosphatidylcholine diacyl C36:3 measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0801259
Disease	phosphatidylcholine diacyl C34:4 measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0801255
Disease	2-linoleoyl-GPC (18:2) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0800239
Disease	1-dihomo-linoleoyl-GPC (20:2) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0800236
Disease	level of Phosphatidylcholine (O-16:0_22:5) in blood serum	FADS2 FADS1	4.13e-06	4	25	2	OBA_2045117
Disease	sphingomyeline C16:1 measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0801318
Disease	docosapentaenoate (n6 DPA; 22:5n6) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0800249
Disease	1-linoleoyl-2-linolenoyl-GPC (18:2/18:3) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0800483
Disease	eicosapentaenoylcholine measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0800482
Disease	comprehensive strength index, muscle measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0004515, EFO_0004979
Disease	1-stearoyl-2-adrenoyl-GPC (18:0/22:4) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0800459
Disease	1-palmitoyl-2-meadoyl-GPC (16:0/20:3n9) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0800458
Disease	phosphatidylcholine (18:0/20:5, 16:0/22:5n6) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0800468
Disease	1-stearoyl-2-meadoyl-GPC (18:0/20:3n9) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0800463
Disease	1-pentadecanoyl-2-arachidonoyl-GPC (15:0/20:4) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0800446
Disease	1-palmitoyl-2-alpha-linolenoyl-GPC (16:0/18:3n3) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0800442
Disease	1-palmitoyl-2-eicosapentaenoyl-GPC (16:0/20:5) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0800408
Disease	phosphatidylcholine 33:2 measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0021470
Disease	phosphatidylcholine 33:1 measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0021469
Disease	1-linoleoyl-2-docosahexaenoyl-GPC (18:2/22:6) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0022080
Disease	1-margaroyl-2-arachidonoyl-GPC (17:0/20:4) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0022081
Disease	1-arachidoyl-2-arachidonoyl-GPC (20:0/20:4) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0022079
Disease	1,2-dilinoleoyl-GPC (18:2/18:2) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0800388
Disease	1-eicosapentaenoyl-GPC (20:5) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0800355
Disease	phosphatidylcholine (O-18:1/20:4, O-16:0/22:5n3) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0800553
Disease	1-(1-enyl-stearoyl)-GPC (P-18:0) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0800325
Disease	1-(1-enyl-oleoyl)-GPC (P-18:1) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0800324
Disease	1-lignoceroyl-GPC (24:0) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0800322
Disease	1-adrenoyl-GPC (22:4) measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0800321
Disease	arachidonate 20:4n6-to-dihomo-linolenate 20:3n3 or n6 ratio	FADS2 FADS1	4.13e-06	4	25	2	EFO_0021517
Disease	fatty acid measurement, linolenic acid measurement	FADS2 FADS1	4.13e-06	4	25	2	EFO_0005110, EFO_0006811
Disease	phosphatidylcholine acyl-alkyl C36:5 measurement	FADS2 FADS1	6.88e-06	5	25	2	EFO_0801293
Disease	2-arachidonoyl-GPC (20:4) measurement	FADS2 FADS1	6.88e-06	5	25	2	EFO_0800237
Disease	1-arachidonoyl-GPC (20:4n6) measurement	FADS2 FADS1	6.88e-06	5	25	2	EFO_0800234
Disease	sphingomyeline C18:1 measurement	FADS2 FADS1	6.88e-06	5	25	2	EFO_0801320
Disease	1-palmitoleoyl-2-linolenoyl-GPC (16:1/18:3) measurement	FADS2 FADS1	6.88e-06	5	25	2	EFO_0800484
Disease	phosphatidylcholine (16:0/22:5n3, 18:1/20:4) measurement	FADS2 FADS1	6.88e-06	5	25	2	EFO_0800467
Disease	1-linoleoyl-GPC (18:2) measurement	FADS2 FADS1	6.88e-06	5	25	2	EFO_0800223
Disease	1-(1-enyl-stearoyl)-2-arachidonoyl-GPE (P-18:0/20:4) measurement	FADS2 FADS1	6.88e-06	5	25	2	EFO_0800415
Disease	1-palmitoyl-2-dihomo-linolenoyl-GPC (16:0/20:3n3 or 6) measurement	FADS2 FADS1	6.88e-06	5	25	2	EFO_0800407
Disease	1-(1-enyl-palmitoyl)-2-arachidonoyl-GPE (P-16:0/20:4) measurement	FADS2 FADS1	6.88e-06	5	25	2	EFO_0800417
Disease	1-linolenoyl-GPE (18:3) measurement	FADS2 FADS1	6.88e-06	5	25	2	EFO_0800365
Disease	1-(1-enyl-stearoyl)-GPE (P-18:0) measurement	FADS2 FADS1	6.88e-06	5	25	2	EFO_0800335
Disease	fatty acid measurement, docosapentaenoic acid measurement	FADS2 FADS1	6.88e-06	5	25	2	EFO_0005110, EFO_0006809
Disease	Sphingomyelin (d18:1/20:1, d18:2/20:0) measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0022110
Disease	Sphingomyelin (d18:1/18:1, d18:2/18:0) measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0022108
Disease	adrenate 22:4n6 measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0021062
Disease	1-arachidonoylglycerophosphocholine measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0021076
Disease	dihomo-linolenate 20:3n3 or n6 measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0021046
Disease	docosapentaenoate n3 DPA; 22:5n3 measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0021048
Disease	1-linoleoylglycerophosphoethanolamine measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0021084
Disease	level of Phosphatidylcholine (18:2_0:0) in blood serum	FADS2 FADS1	1.03e-05	6	25	2	OBA_2045105
Disease	1-(1-enyl-stearoyl)-2-arachidonoyl-GPC (P-18:0/20:4) measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0800394
Disease	1-palmitoyl-2-arachidonoyl-GPC (16:0/20:4n6) measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0800390
Disease	level of Phosphatidylcholine (O-18:2_18:2) in blood serum	FADS2 FADS1	1.03e-05	6	25	2	OBA_2045134
Disease	level of Phosphatidylcholine (O-16:0_18:2) in blood serum	FADS2 FADS1	1.03e-05	6	25	2	OBA_2045114
Disease	arachidonoylcholine measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0800478
Disease	1-oleoyl-2-docosahexaenoyl-GPE (18:1/22:6) measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0800471
Disease	1-stearoyl-GPC (18:0) measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0800217
Disease	1-arachidonylglycerol (20:4) measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0800224
Disease	1-stearoyl-2-dihomo-linolenoyl-GPC (18:0/20:3n3 or 6) measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0800434
Disease	level of Phosphatidylinositol (18:1_18:2) in blood serum	FADS2 FADS1	1.03e-05	6	25	2	OBA_2045160
Disease	1-palmitoyl-2-dihomo-linolenoyl-GPE (16:0/20:3) measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0800444
Disease	1-palmityl-2-arachidonoyl-GPC (O-16:0/20:4) measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0800426
Disease	1-stearoyl-2-linoleoyl-GPC (18:0/18:2) measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0800404
Disease	lysophosphatidylcholine 18:3 measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0021454
Disease	procollagen C-endopeptidase enhancer 1 measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0801920
Disease	1-docosapentaenoyl-GPC (22:5n3) measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0800298
Disease	1-(1-enyl-palmitoyl)-GPC (P-16:0) measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0800323
Disease	level of Phosphatidylcholine (18:0_20:2) in blood serum	FADS2 FADS1	1.03e-05	6	25	2	OBA_2045092
Disease	arachidonic acid measurement, fatty acid measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0005110, EFO_0006808
Disease	1-(1-enyl-stearoyl)-2-linoleoyl-GPE (P-18:0/18:2)* measurement	FADS2 FADS1	1.03e-05	6	25	2	EFO_0020014
Disease	arachidonate 20:4n6 measurement	FADS2 FADS1	1.44e-05	7	25	2	EFO_0021063
Disease	X-24870 measurement	FADS2 FADS1	1.44e-05	7	25	2	EFO_0022143
Disease	1-eicosatrienoylglycerophosphocholine measurement	FADS2 FADS1	1.44e-05	7	25	2	EFO_0021081
Disease	1,2-dipalmitoyl-GPC (16:0/16:0) measurement	FADS2 FADS1	1.44e-05	7	25	2	EFO_0800189
Disease	level of Phosphatidylcholine (18:2_20:3) in blood serum	FADS2 FADS1	1.44e-05	7	25	2	OBA_2045108
Disease	1-palmitoyl-2-docosahexaenoyl-GPC (16:0/22:6) measurement	FADS2 FADS1	1.44e-05	7	25	2	EFO_0800391
Disease	level of Phosphatidylcholine (O-18:2_18:1) in blood serum	FADS2 FADS1	1.44e-05	7	25	2	OBA_2045133
Disease	1-arachidonoyl-GPI (20:4) measurement	FADS2 FADS1	1.44e-05	7	25	2	EFO_0800256
Disease	level of Phosphatidylcholine (O-18:2_20:4) in blood serum	FADS2 FADS1	1.44e-05	7	25	2	OBA_2045135
Disease	1-linoleoyl-GPI (18:2) measurement	FADS2 FADS1	1.44e-05	7	25	2	EFO_0800266
Disease	1-oleoyl-2-arachidonoyl-GPE (18:1/20:4) measurement	FADS2 FADS1	1.44e-05	7	25	2	EFO_0800470
Disease	level of Sphingomyelin (d36:2) in blood serum	FADS2 FADS1	1.44e-05	7	25	2	OBA_2045177
Disease	1-oleoyl-2-linoleoyl-GPE (18:1/18:2) measurement	FADS2 FADS1	1.44e-05	7	25	2	EFO_0800443
Disease	lysophosphatidylcholine 22:4 measurement	FADS2 FADS1	1.44e-05	7	25	2	EFO_0021461
Disease	1-palmitoyl-2-linoleoyl-GPI (16:0/18:2) measurement	FADS2 FADS1	1.44e-05	7	25	2	EFO_0800609
Disease	phosphatidylcholine 35:5 measurement	FADS2 FADS1	1.44e-05	7	25	2	EFO_0021472
Disease	eicosapentaenoate (EPA; 20:5n3) measurement	FADS2 FADS1	1.44e-05	7	25	2	EFO_0800616

Protein segments in the cluster

Peptide	Gene	Start	Entry
IKFFHAQHNFFQDGW	ASAP3	216	Q8TDY4
FFLKSCFWFQHGRAN	ABCA9	436	Q8IUA7
GGFVVHWLNNKEFHF	DMXL2	386	Q8TDJ6
ESSKQHFFHLWNDFA	CEMIP	1216	Q8WUJ3
HKGWDFVEGYFHQFF	MMP26	26	Q9NRE1
FHCHRGQDFVIFFWK	RNF216P1	16	Q6NUR6
NGNFEEIQHFLLHFW	RFX6	281	Q8HWS3
EHFYFWLNSLKEFSH	INTS7	556	Q9NVH2
FPFAHWLAFFNSSAN	NPFFR1	311	Q9GZQ6
FNDWFSGHLNFQIEH	FADS2	371	O95864
TDNVFWGEHFEFHNL	DAB2IP	251	Q5VWQ8
FGNIHQIYDWHKDFF	KALRN	1976	O60229
EFLHFLTDQFSGQHW	LY75	696	O60449
ARSWDHNEFFAQFAG	KDM1B	556	Q8NB78
FNDWFSGHLNFQIEH	FADS1	371	O60427
FGFYKWHHEPAEFQA	HEXB	106	P07686
GYAGIFHFQFWQHSE	CAPN9	126	O14815
EHAFEHWQEDAFFAS	ALOX15B	226	O15296
LPGHWVFFFSHFNFD	RTL1	966	A6NKG5
FGHFWQLFNALTLFN	TMEM120A	281	Q9BXJ8
QEHLTEYGVHWNFFF	PIGW	226	Q7Z7B1
QFGNEDHHEFIWKFH	TRIM74	231	Q86UV6
LNFFNWFSDHNFAGS	TSPY9	261	A0A494C1R9
NFFNWFSDHNFAGSN	TSPY10	256	P0CW01
NFFNWFSDHNFAGSN	TSPY2	256	A6NKD2
LNFFNWFSDHNFAGS	TSPY4	261	P0CV99
NFFNWFSDHNFAGSN	TSPY1	256	Q01534
NFFNWFSDHNFAGSN	TSPY3	256	P0CV98
NFFNWFSDHNFAGSN	TSPY8	256	P0CW00
ANRHWFSFLFPFIHF	nan	136	Q8N9P0
QFGNEDHHEFIWKFH	TRIM73	231	Q86UV7
HLFFHKENDWGFSNF	USP7	156	Q93009