Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF708 ZNF141 ZNF723 ZNF273 ZNF257 ZNF43 MTOR GLIS1 ZNF280C	9.36e-05	1271	31	9	GO:0000987
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF708 ZNF141 ZNF723 ZNF273 ZNF257 ZNF43 GLIS1 ZNF280C	4.82e-04	1244	31	8	GO:0000978
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF708 ZNF141 ZNF723 ZNF273 ZNF257 ZNF43 GLIS1 ZNF280C	1.11e-03	1412	31	8	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF708 ZNF141 ZNF723 ZNF273 ZNF257 ZNF43 GLIS1 ZNF280C	1.38e-03	1459	31	8	GO:0000977
Domain	ZINC_FINGER_C2H2_2	ZNF708 ZNF141 ZNF273 ZNF257 ZNF43 GLIS1 ZNF280C	1.14e-04	775	28	7	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF708 ZNF141 ZNF273 ZNF257 ZNF43 GLIS1 ZNF280C	1.16e-04	777	28	7	PS00028
Domain	Znf_C2H2-like	ZNF708 ZNF141 ZNF273 ZNF257 ZNF43 GLIS1 ZNF280C	1.34e-04	796	28	7	IPR015880
Domain	Znf_C2H2	ZNF708 ZNF141 ZNF273 ZNF257 ZNF43 GLIS1 ZNF280C	1.44e-04	805	28	7	IPR007087
Domain	ZnF_C2H2	ZNF708 ZNF141 ZNF273 ZNF257 ZNF43 GLIS1 ZNF280C	1.47e-04	808	28	7	SM00355
Domain	KRAB	ZNF708 ZNF141 ZNF273 ZNF257 ZNF43	1.72e-04	358	28	5	PS50805
Domain	KRAB	ZNF708 ZNF141 ZNF273 ZNF257 ZNF43	1.72e-04	358	28	5	PF01352
Domain	KRAB	ZNF708 ZNF141 ZNF273 ZNF257 ZNF43	1.98e-04	369	28	5	SM00349
Domain	KRAB	ZNF708 ZNF141 ZNF273 ZNF257 ZNF43	2.01e-04	370	28	5	IPR001909
Domain	PI3/4_kinase_CS	MTOR PIK3CD	2.25e-04	15	28	2	IPR018936
Domain	PI3Kc	MTOR PIK3CD	2.57e-04	16	28	2	SM00146
Domain	-	MTOR PIK3CD	2.57e-04	16	28	2	1.10.1070.11
Domain	PI3_4_KINASE_1	MTOR PIK3CD	3.27e-04	18	28	2	PS00915
Domain	PI3_4_KINASE_2	MTOR PIK3CD	3.27e-04	18	28	2	PS00916
Domain	PI3/4_kinase_cat_dom	MTOR PIK3CD	3.27e-04	18	28	2	IPR000403
Domain	PI3_PI4_kinase	MTOR PIK3CD	3.27e-04	18	28	2	PF00454
Domain	PI3_4_KINASE_3	MTOR PIK3CD	3.27e-04	18	28	2	PS50290
Domain	-	ZNF708 ZNF141 ZNF273 ZNF257 ZNF43 GLIS1	4.29e-04	679	28	6	3.30.160.60
Domain	zf-C2H2	ZNF708 ZNF141 ZNF273 ZNF257 ZNF43 GLIS1	4.78e-04	693	28	6	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF708 ZNF141 ZNF273 ZNF257 ZNF43 GLIS1	4.82e-04	694	28	6	IPR013087
Pathway	REACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS_BY_KRAB_ZFP_PROTEINS	ZNF708 ZNF141 ZNF273 ZNF257	1.70e-05	107	21	4	M48260
Pathway	REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION	ZNF708 KMT2C ZNF141 ZNF273 ZNF257	2.93e-05	254	21	5	M27131
Pathway	REACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS	ZNF708 ZNF141 ZNF273 ZNF257	5.17e-05	142	21	4	M48257
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_PI3K_SIGNALING_PATHWAY	MTOR PIK3CD	5.89e-05	8	21	2	M47399
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_EGFR_TO_PI3K_SIGNALING_PATHWAY	MTOR PIK3CD	5.89e-05	8	21	2	M47394
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_RET_TO_PI3K_SIGNALING_PATHWAY	MTOR PIK3CD	5.89e-05	8	21	2	M47715
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_PI3K_SIGNALING_PATHWAY	MTOR PIK3CD	7.56e-05	9	21	2	M47397
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_MET_TO_PI3K_SIGNALING_PATHWAY	MTOR PIK3CD	7.56e-05	9	21	2	M47490
Pathway	KEGG_MEDICUS_REFERENCE_TGFA_EGFR_PI3K_SIGNALING_PATHWAY	MTOR PIK3CD	7.56e-05	9	21	2	M47481
Pathway	KEGG_MEDICUS_VARIANT_EGFR_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	MTOR PIK3CD	9.44e-05	10	21	2	M47400
Pathway	KEGG_MEDICUS_REFERENCE_IGF2_IGF1R_PI3K_SIGNALING_PATHWAY	MTOR PIK3CD	1.15e-04	11	21	2	M47484
Pathway	KEGG_MEDICUS_REFERENCE_EREG_EGFR_PI3K_SIGNALING_PATHWAY	MTOR PIK3CD	1.15e-04	11	21	2	M47499
Pathway	KEGG_MEDICUS_REFERENCE_KITLG_KIT_PI3K_SIGNALING_PATHWAY	MTOR PIK3CD	1.15e-04	11	21	2	M47403
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01339	MTOR PIK3CD	1.15e-04	11	21	2	M47791
Pathway	KEGG_MEDICUS_REFERENCE_AREG_EGFR_PI3K_SIGNALING_PATHWAY	MTOR PIK3CD	1.15e-04	11	21	2	M47501
Pathway	KEGG_MEDICUS_VARIANT_ERBB2_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	MTOR PIK3CD	1.38e-04	12	21	2	M47393
Pathway	WP_RESOLVIN_E1_AND_RESOLVIN_D1_SIGNALING_DECREASE_INFLAMMATION	MTOR PIK3CD	1.38e-04	12	21	2	M45559
Pathway	KEGG_MEDICUS_REFERENCE_PDGF_PDGFR_PI3K_SIGNALING_PATHWAY	MTOR PIK3CD	1.63e-04	13	21	2	M47398
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGF1R_PI3K_SIGNALING_PATHWAY	MTOR PIK3CD	1.63e-04	13	21	2	M47603
Pathway	KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY	MTOR PIK3CD	2.19e-04	15	21	2	M47475
Pathway	KEGG_MEDICUS_REFERENCE_RELN_VLDLR_PI3K_SIGNALING_PATHWAY	MTOR PIK3CD	2.19e-04	15	21	2	M47663
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	AUTS2 ZNF708 KMT2C ZNF141 ZNF273 ZNF257 ZNF43 MTOR	5.42e-04	1387	21	8	M734
Pathway	WP_4HYDROXYTAMOXIFEN_DEXAMETHASONE_AND_RETINOIC_ACIDS_REGULATION_OF_P27_EXPRESSION	MTOR PIK3CD	6.21e-04	25	21	2	M39574
Pathway	KEGG_MEDICUS_REFERENCE_FGF_FGFR_PI3K_SIGNALING_PATHWAY	MTOR PIK3CD	9.58e-04	31	21	2	M47396
Pathway	PID_CXCR3_PATHWAY	MTOR PIK3CD	1.84e-03	43	21	2	M222
Pathway	PID_ERBB2_ERBB3_PATHWAY	MTOR PIK3CD	1.93e-03	44	21	2	M175
Pathway	KEGG_TYPE_II_DIABETES_MELLITUS	MTOR PIK3CD	2.19e-03	47	21	2	M19708
Pathway	WP_SYNAPTIC_SIGNALING_ASSOCIATED_WITH_AUTISM_SPECTRUM_DISORDER	MTOR PIK3CD	2.48e-03	50	21	2	M39822
Pathway	KEGG_MTOR_SIGNALING_PATHWAY	MTOR PIK3CD	2.68e-03	52	21	2	M7561
Pathway	WP_INTERFERON_TYPE_I_SIGNALING	MTOR PIK3CD	2.89e-03	54	21	2	M39435
Pathway	KEGG_ACUTE_MYELOID_LEUKEMIA	MTOR PIK3CD	3.21e-03	57	21	2	M19888
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	OSBPL8 AUTS2 KMT2C GRIP2 ARHGEF10 GNPTAB	5.40e-08	225	32	6	12168954
Pubmed	IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ motif protein.	SCHIP1 IQCJ-SCHIP1	2.46e-06	3	32	2	17045569
Pubmed	Regulation of adiponectin secretion by insulin and amino acids in 3T3-L1 adipocytes.	MTOR PIK3CD	2.46e-06	3	32	2	19013287
Pubmed	TLR4 inhibited autophagy by modulating PI3K/AKT/mTOR signaling pathway in Gastric cancer cell lines.	MTOR PIK3CD	4.92e-06	4	32	2	37257791
Pubmed	Schwannomin-interacting Protein 1 Isoform IQCJ-SCHIP1 Is a Multipartner Ankyrin- and Spectrin-binding Protein Involved in the Organization of Nodes of Ranvier.	SCHIP1 IQCJ-SCHIP1	4.92e-06	4	32	2	27979964
Pubmed	KIRREL promotes the proliferation of gastric cancer cells and angiogenesis through the PI3K/AKT/mTOR pathway.	MTOR PIK3CD	4.92e-06	4	32	2	37909722
Pubmed	CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.	SCHIP1 IQCJ-SCHIP1	8.19e-06	5	32	2	25950943
Pubmed	Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late component of nodes of Ranvier and axon initial segments.	SCHIP1 IQCJ-SCHIP1	8.19e-06	5	32	2	18550753
Pubmed	PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells.	MTOR PIK3CD	1.23e-05	6	32	2	23183047
Pubmed	HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway.	MTOR PIK3CD	4.49e-05	11	32	2	25104021
Pubmed	Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala.	AUTS2 GPR101 FHIP1A	7.36e-05	88	32	3	21491433
Pubmed	Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering.	ZNF708 ZNF43	7.41e-05	14	32	2	2014798
Pubmed	Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.	MTOR PIK3CD	1.11e-04	17	32	2	25327288
Pubmed	Rebalancing gene haploinsufficiency in vivo by targeting chromatin.	KMT2C PIK3CD	3.05e-04	28	32	2	27256596
Pubmed	Multiple genes encoding zinc finger domains are expressed in human T cells.	ZNF708 ZNF43	3.75e-04	31	32	2	2288909
Pubmed	DHHC protein family targets different subsets of glioma stem cells in specific niches.	MTOR PIK3CD	4.25e-04	33	32	2	30658672
Pubmed	Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.	SCHIP1 IQCJ-SCHIP1	4.52e-04	34	32	2	19197348
Pubmed	TWIST1 interacts with β/δ-catenins during neural tube development and regulates fate transition in cranial neural crest cells.	MTOR PIK3CD	5.95e-04	39	32	2	35781329
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF708 ZNF273 ZNF257	6.15e-04	181	32	3	37372979
Pubmed	Exome sequencing supports a de novo mutational paradigm for schizophrenia.	MTOR CFAP65	6.26e-04	40	32	2	21822266
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	UBA6 PRPF39 MTOR	6.35e-04	183	32	3	31932471
Pubmed	Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination.	KMT2C RAB11FIP1	6.58e-04	41	32	2	34638806
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	KMT2C MTOR	7.23e-04	43	32	2	33472061
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF708 ZNF723 ZNF257 ZNF43	1.61e-06	122	32	4	chr19p12
Cytoband	1p36.2	MTOR PIK3CD	3.65e-05	13	32	2	1p36.2
Cytoband	19p12	ZNF708 ZNF723	1.81e-03	90	32	2	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chrXq26	GPR101 ZNF280C	6.36e-03	171	32	2	chrXq26
Cytoband	Ensembl 112 genes in cytogenetic band chr3q25	SCHIP1 IQCJ-SCHIP1	7.02e-03	180	32	2	chr3q25
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	TEX46 MTOR PIK3CD	1.17e-02	681	32	3	chr1p36
Cytoband	Ensembl 112 genes in cytogenetic band chr7q11	AUTS2 ZNF273	1.53e-02	271	32	2	chr7q11
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF708 ZNF141 ZNF273 ZNF257 ZNF43 GLIS1	1.25e-04	718	21	6	28
GeneFamily	PDZ domain containing	GRIP2 SDCBP2	1.33e-02	152	21	2	1220
ToppCell	PCW_13-14-Epithelial-Epithelial_airway-epi_intermediate_(1)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	IQCJ-SCHIP1 RAB11FIP1 IL1RAPL2 FHIP1A	1.05e-05	192	32	4	b73f24d1c55dfef1eb01c26da117dbf637ea080a
ToppCell	PCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	IQCJ-SCHIP1 RAB11FIP1 IL1RAPL2 FHIP1A	1.05e-05	192	32	4	450baeb5c3df7a9445472530002ce38f177a333c
ToppCell	PCW_13-14-Epithelial-Epithelial_airway\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	IQCJ-SCHIP1 RAB11FIP1 IL1RAPL2 FHIP1A	1.10e-05	194	32	4	7b2b40a56eb9c7203ca50133b2da4fd8fdd4a5cf
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	IQCJ-SCHIP1 RAB11FIP1 IL1RAPL2 FHIP1A	1.12e-05	195	32	4	d673f8844896d5c7b76a7bc7f6b88a039f1bc263
Disease	Lymphoma, Lymphocytic, Intermediate	MTOR PIK3CD	5.46e-05	11	30	2	C0751958
Disease	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	MTOR PIK3CD	1.19e-04	16	30	2	C0334634
Disease	synophrys measurement	AUTS2 GLIS1	2.18e-03	68	30	2	EFO_0007906
Disease	Testicular Germ Cell Tumor	ZNF257 PIK3CD	2.51e-03	73	30	2	EFO_1000566
Disease	thyroxine measurement	SLC22A9 IL1RAPL2	3.23e-03	83	30	2	EFO_0005130
Disease	corpus callosum volume measurement	SCHIP1 IQCJ-SCHIP1	4.65e-03	100	30	2	EFO_0010299
Disease	type 2 diabetes mellitus (implicated_via_orthology)	PIK3CD GLIS1	5.11e-03	105	30	2	DOID:9352 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KHPLLVGHMPVMVAK	ARHGEF10	876	O15013
RPMSVHMPAMKICEK	CDNF	101	Q49AH0
ICHPLHYPMLMSKKI	OR2AK2	141	Q8NG84
MLCPMHKPKGIHEQE	KMT2C	4501	Q8NEZ4
RKVPAHMPHMIDRIV	GNPTAB	951	Q3T906
LPKMCLHMAVRHSKA	FOXL2NB	56	Q6ZUU3
PVPLCLMNHTKGKIM	CFAP65	671	Q6ZU64
PMLRKPGKWCAMHVH	AUTS2	641	Q8WXX7
HTCMPLSKMPISLAH	GPR101	16	Q96P66
RACTIHLPKKPMVHM	PRPF39	411	Q86UA1
KHRTPMVSVPKMKHK	OSBPL8	771	Q9BZF1
HKPILKPLMMLLSSC	FHIP1A	136	Q05DH4
HMAKLMEHVRLPLLP	KLHL3	231	Q9UH77
IHMRVHSGEKPNKCM	GLIS1	251	Q8NBF1
PLEMHKVTLHKDPMR	GRIP2	936	Q9C0E4
KMLSLVLMHKPLRHP	MTOR	541	P42345
SAKHRLHPVKPMNAM	RAB11FIP1	1171	Q6WKZ4
HMPHISECLMKRSLK	SCHIP1	401	P0DPB3
AQKKKPSLCEMLHMP	SLC22A9	331	Q8IVM8
MPIKKKEMLPRCHVL	IL1RAPL2	556	Q9NP60
PHMPHISECLMKRSL	IQCJ-SCHIP1	476	B3KU38
HMVKKLPPVLLHHTM	SDCBP2	271	Q9H190
PVMPGHAKRLKLTMH	UBA6	996	A0AVT1
CNMKRHAMVAKPPVV	ZNF273	96	Q14593
KRHKMVAKPPVVCSH	ZNF723	66	P0DPD5
TPKPQTKELMHLCMR	PIK3CD	706	O00329
KIHKIVARPPAMCSH	ZNF141	66	Q15928
MRRHEMVAKPPVMCS	ZNF43	66	P17038
KRHEMAAKPPAMCSH	ZNF708	66	P17019
PLKYHMKHCCPDMIT	ZNF280C	251	Q8ND82
PMKKHRMRRHESICP	TEX46	96	H3BTG2
KRHEMVAKPPVMCSH	ZNF257	66	Q9Y2Q1