Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionserine-type endopeptidase inhibitor activity

ANOS1 SERPINA4 SERPINB10 SERPINB12

1.38e-04105504GO:0004867
GeneOntologyMolecularFunctionRNA polymerase I general transcription initiation factor activity

RRN3 RRN3P1

2.19e-049502GO:0001181
GeneOntologyMolecularFunctionphospholipid transporter activity

ANO4 ANO7 PITPNB

8.45e-0474503GO:0005548
GeneOntologyMolecularFunctionendopeptidase inhibitor activity

ANOS1 SERPINA4 SERPINB10 SERPINB12

1.06e-03180504GO:0004866
GeneOntologyMolecularFunctionintracellularly calcium-gated channel activity

ANO4 ANO7

1.13e-0320502GO:0141147
GeneOntologyMolecularFunctionintracellularly calcium-gated chloride channel activity

ANO4 ANO7

1.13e-0320502GO:0005229
GeneOntologyMolecularFunctionpeptidase inhibitor activity

ANOS1 SERPINA4 SERPINB10 SERPINB12

1.23e-03187504GO:0030414
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

ANO4 CATSPER1 ANO7 GRIK4

1.38e-03193504GO:0015276
GeneOntologyMolecularFunctiongated channel activity

ANO4 CATSPER1 ANO7 KCNS2 GRIK4

1.45e-03334505GO:0022836
GeneOntologyMolecularFunctionligand-gated channel activity

ANO4 CATSPER1 ANO7 GRIK4

1.48e-03197504GO:0022834
GeneOntologyMolecularFunctionphospholipid scramblase activity

ANO4 ANO7

1.50e-0323502GO:0017128
GeneOntologyMolecularFunctionendopeptidase regulator activity

ANOS1 SERPINA4 SERPINB10 SERPINB12

1.60e-03201504GO:0061135
GeneOntologyMolecularFunctionphosphatidylinositol kinase activity

PIK3C2A PIP5KL1

1.92e-0326502GO:0052742
GeneOntologyBiologicalProcesscalcium activated phosphatidylserine scrambling

ANO4 ANO7

3.73e-054522GO:0061589
GeneOntologyBiologicalProcesscalcium activated phospholipid scrambling

ANO4 ANO7

6.20e-055522GO:0061588
GeneOntologyBiologicalProcesscalcium activated phosphatidylcholine scrambling

ANO4 ANO7

6.20e-055522GO:0061590
GeneOntologyBiologicalProcesscalcium activated galactosylceramide scrambling

ANO4 ANO7

6.20e-055522GO:0061591
MousePhenoabnormal calcium ion homeostasis

TCTN3 CATSPER1 SERPINB10 ANK1 PTDSS1 ZFYVE26 GPRC6A FRYL

1.55e-05404408MP:0004231
DomainSerpin_CS

SERPINA4 SERPINB10 SERPINB12

8.48e-0532503IPR023795
DomainSerpin_dom

SERPINA4 SERPINB10 SERPINB12

1.21e-0436503IPR023796
DomainSERPIN

SERPINA4 SERPINB10 SERPINB12

1.32e-0437503SM00093
DomainSERPIN

SERPINA4 SERPINB10 SERPINB12

1.32e-0437503PS00284
DomainSerpin

SERPINA4 SERPINB10 SERPINB12

1.43e-0438503PF00079
DomainAnoct_dimer

ANO4 ANO7

1.46e-047502PF16178
DomainAnoct_dimer

ANO4 ANO7

1.46e-047502IPR032394
DomainMob1_phocein

MOB1B MOB1A

1.46e-047502PF03637
DomainMOB_kinase_act_fam

MOB1B MOB1A

1.46e-047502IPR005301
Domain-

MOB1B MOB1A

1.46e-0475021.20.140.30
DomainMob1_phocein

MOB1B MOB1A

1.46e-047502SM01388
DomainSerpin_fam

SERPINA4 SERPINB10 SERPINB12

1.54e-0439503IPR000215
DomainAnoctamin

ANO4 ANO7

3.12e-0410502PF04547
DomainAnoctamin

ANO4 ANO7

3.12e-0410502IPR007632
DomainANF_lig-bd_rcpt

GPRC6A GRIK4

4.41e-0337502IPR001828
DomainANF_receptor

GPRC6A GRIK4

4.41e-0337502PF01094
DomainPeripla_BP_I

GPRC6A GRIK4

4.89e-0339502IPR028082
Pubmed

Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling.

MOB1B MOB1A

2.28e-06253230349003
Pubmed

Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice.

MOB1B MOB1A

2.28e-06253223143302
Pubmed

Human Mob1 proteins are required for cytokinesis by controlling microtubule stability.

MOB1B MOB1A

2.28e-06253222454515
Pubmed

EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1.

MOB1B MOB1A

6.83e-06353234725466
Pubmed

The human tumour suppressor LATS1 is activated by human MOB1 at the membrane.

MOB1B MOB1A

6.83e-06353216674920
Pubmed

PTEN-GSK3β-MOB1 axis controls neurite outgrowth in vitro and in vivo.

MOB1B MOB1A

1.36e-05453230069702
Pubmed

Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein.

MOB1B MOB1A

1.36e-05453215197186
Pubmed

Pharmacogenetics of Sertraline Tolerability and Response in Pediatric Anxiety and Depressive Disorders.

CYP2C19 GRIK4

1.36e-05453231066578
Pubmed

The transcription factor GATA-4 regulates cytochrome P4502C19 gene expression.

CYP2C19 ZFPM2

2.27e-05553220206639
Pubmed

YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma.

MOB1B MOB1A

2.27e-05553232206709
Pubmed

Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers.

MOB1B MOB1A

3.40e-05653235858357
Pubmed

Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice.

MOB1B MOB1A

3.40e-05653232716083
Pubmed

YAP determines the cell fate of injured mouse hepatocytes in vivo.

MOB1B MOB1A

3.40e-05653228681838
Pubmed

Update of the human and mouse SERPIN gene superfamily.

SERPINA4 SERPINB10 SERPINB12

3.95e-054353324172014
Pubmed

MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.

MOB1B MOB1A

4.76e-05753218328708
Pubmed

ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins.

ANO4 ANO7

4.76e-05753222075693
Pubmed

Molecular characterization of human homologs of yeast MOB1.

MOB1B MOB1A

6.34e-05853219739119
Pubmed

Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.

MOB1B MOB1A

6.34e-05853226699479
Pubmed

Anoctamins are a family of Ca2+-activated Cl- channels.

ANO4 ANO7

6.34e-05853222946059
Pubmed

Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels.

ANO4 ANO7

1.02e-041053219015192
Pubmed

Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members.

ANO4 ANO7

1.02e-041053223532839
Pubmed

Structure and function of TMEM16 proteins (anoctamins).

ANO4 ANO7

1.02e-041053224692353
Pubmed

Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus.

SERPINB10 SERPINB12

1.24e-041153215203215
Pubmed

The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1.

TMEM39A SEC23A

2.05e-041453231806350
Pubmed

A genome-wide association study on obesity and obesity-related traits.

PITPNB PCDH9

2.36e-041553221552555
Pubmed

MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation.

MOB1B MOB1A

3.43e-041853228346423
Pubmed

Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in Ventricular Development.

MOB1B MOB1A

8.40e-042853237846569
Pubmed

Alternatively spliced isoforms of WT1 control podocyte-specific gene expression.

NELL2 PTPRO

8.40e-042853225993318
Pubmed

Genome-wide association study of lung function decline in adults with and without asthma.

ANK1 PCDH9

1.10e-033253222424883
Cytoband8q22

PTDSS1 KCNS2

1.36e-04155328q22
Cytoband10p14

SFMBT2 CELF2-AS1

4.18e-042653210p14
CytobandEnsembl 112 genes in cytogenetic band chr8q22

PTDSS1 KCNS2 ZFPM2

9.86e-04168533chr8q22
CytobandEnsembl 112 genes in cytogenetic band chr10p14

SFMBT2 CELF2-AS1

1.49e-0349532chr10p14
GeneFamilySerpin peptidase inhibitors

SERPINA4 SERPINB10 SERPINB12

5.38e-0537363739
GeneFamilyMOB kinase activators|STRIPAK complex

MOB1B MOB1A

8.04e-057362647
GeneFamilyAnoctamins

ANO4 ANO7

1.72e-0410362865
Diseaselysosomal protective protein measurement

WASHC3 ZFPM2

6.12e-057512EFO_0008215
Diseasevenous thromboembolism, plasminogen activator inhibitor 1 measurement

PLEK ZFPM2

6.02e-0421512EFO_0004286, EFO_0004792
Diseasevenous thromboembolism, tissue plasminogen activator measurement

PLEK ZFPM2

7.24e-0423512EFO_0004286, EFO_0004791
Diseaseunipolar depression, neuroticism measurement

ANO4 PHF3

7.89e-0424512EFO_0003761, EFO_0007660
Diseaseseasonal gut microbiome measurement

NELL2 PTDSS1 ZFPM2

9.71e-04112513EFO_0007753
Diseasefactor XI measurement, venous thromboembolism

PLEK ZFPM2

1.24e-0330512EFO_0004286, EFO_0004694
Diseasefactor VIII measurement, venous thromboembolism

PLEK ZFPM2

1.59e-0334512EFO_0004286, EFO_0004630
Diseasegranulocyte colony-stimulating factor measurement

ANO4 ANK1

1.59e-0334512EFO_0008142

Protein segments in the cluster

PeptideGeneStartEntry
KRFQNIFTTIFTLFT

CATSPER1

611

Q8NEC5
KAAQQRSFHFQSFRE

ANK1

1306

P16157
HNSKNQFFTIFFFLS

LINC01587

11

Q99440
FVAFTNHFKQVFSDV

DMD

911

P11532
SKFAQFRRLNFAQIH

DMD

1961

P11532
FIIHNKETFFNNATR

ANO4

246

Q32M45
QDTFFTSTKRHQILF

ANO7

246

Q6IWH7
LQITRISAFFQHFQN

ANOS1

56

P23352
SFFLSHDQRFFLKTQ

PIP5KL1

141

Q5T9C9
QFFQKLRNKHEFTIL

NELL2

76

Q99435
SVQGFKEALFQFFHN

IP6K2

281

Q9UHH9
DTFFFILRKNNHQIT

ELOVL5

126

Q9NYP7
FSVHSCFFNFQVRKI

CELF2-AS1

166

Q8N7Q2
NRFHFKLTDQTNNRF

MGAM

181

O43451
FLNVAIFQHFKSLID

MFI

26

Q8NCR3
IQFNNLSNFITHKKF

ZFPM2

1126

Q8WW38
SIATKFNFFIHNLAQ

PIK3C2A

1381

O00443
KFTHNHFQFFVSENL

PCDH9

571

Q9HC56
FHQLLQTFNFRKLQC

DDIAS

181

Q8IXT1
TFHVFSRLFQTIQRK

FRYL

2706

O94915
ITLIFNKFSHFYRRQ

KCNS2

406

Q9ULS6
TSFKHFIFFVQEFNL

MOB1B

181

Q7L9L4
FQRKTQFLFERTFNL

HS6ST3

356

Q8IZP7
NFIQKQEKRIFTNFH

PITPNB

211

P48739
LFTFNHFNDFVNAIK

ARHGAP12

741

Q8IWW6
FVLFKNATAFHVTVQ

PTPRO

21

Q16827
VFLRQFHVFDLFNKA

GPRC6A

276

Q5T6X5
HRAFSVFLFNTENKL

IDI1

51

Q13907
FLFLTFILQNFNLKS

CYP2C19

446

P33261
FFHVAFQGKDILSFQ

CD1D

131

P15813
FFQAKHLIERSQVFN

ADA2

86

Q9NZK5
FFLLFQFCTHINFQK

FIMP

116

Q96LL3
FVKFQFQRFTTLNLH

GRIK4

126

Q16099
QAVFYTFVFRHKQLL

RRN3

461

Q9NYV6
ANFSNFIFLHLKRRV

TAS2R43

111

P59537
KFFSAQTNRHILRFN

SERPINA4

386

P29622
TSFKHFIFFVQEFNL

MOB1A

181

Q9H8S9
ITTTKQQDHFFQAAF

PLEK

71

P08567
FFIRHNKTQTILFYG

SERPINB12

386

Q96P63
SFNTSLFKQTFQRVF

SEC23A

376

Q15436
LLFVRHQFKIAFFSE

TRAPPC11

221

Q7Z392
FNHRIKEVLFNSLFS

TMEM39A

281

Q9NV64
SVTKVFNNHFFQVTI

SFMBT2

321

Q5VUG0
LFHFQDKLTARQFQR

TANGO6

381

Q9C0B7
VQISFFSVKTHIFNN

ZNF534

161

Q76KX8
NDFFNSFTTVLHKQR

PHF3

1396

Q92576
QAVFYTFVFRHKQLL

RRN3P1

86

Q2M238
RIHIFSSFFYKRLNQ

SENP6

706

Q9GZR1
TSFHRFFFTANQVKI

USB1

146

Q9BQ65
FFHSLFTQNKQLQRV

ZBTB47

41

Q9UFB7
LQQHFILRFRAFQQS

TCTN3

356

Q6NUS6
NQFVVHTVQFLNRFS

WASHC3

31

Q9Y3C0
FAEAHQVLFTFNLKS

ZFYVE26

846

Q68DK2
ELNTFFLKHIFVFQA

PTDSS1

301

P48651
LFLSNVFHKAFVEIN

SERPINB10

331

P48595
FLFFIRHNKTNTILF

SERPINB10

376

P48595
ATFFQVFSQLHELRQ

WDR81

1426

Q562E7