Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionWnt receptor activity

FZD1 FZD4 FZD7 FZD8 FZD2

1.73e-0917645GO:0042813
GeneOntologyMolecularFunctionWnt-protein binding

FZD1 FZD4 FZD7 FZD8 FZD2

7.47e-0834645GO:0017147
GeneOntologyMolecularFunctiontransmembrane transporter activity

GABRD SLC5A10 KCNA1 KCNB1 TRPM3 ABCA13 KCNMA1 ABCC5 ABCC12 GRIN1 SPNS3 SLC48A1 SLC37A4 SLC9A6 RHD SLC5A2 ITPR3

1.14e-0711806417GO:0022857
GeneOntologyMolecularFunctiontransporter activity

GABRD SLC5A10 KCNA1 KCNB1 TRPM3 ABCA13 KCNMA1 ABCC5 ABCC12 GRIN1 SPNS3 SLC48A1 SLC37A4 SLC9A6 RHD SLC5A2 ITPR3

4.01e-0712896417GO:0005215
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

GABRD SLC5A10 KCNA1 KCNB1 TRPM3 KCNMA1 ABCC5 GRIN1 SLC37A4 SLC9A6 RHD SLC5A2 ITPR3

6.73e-077586413GO:0015318
GeneOntologyMolecularFunctionPDZ domain binding

FZD1 FZD4 FZD7 FZD8 CNTNAP4 FZD2

2.71e-06123646GO:0030165
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC5A10 KCNA1 KCNB1 TRPM3 KCNMA1 GRIN1 SLC9A6 SLC5A2 ITPR3

1.65e-05465649GO:0046873
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC5A10 KCNA1 KCNB1 TRPM3 KCNMA1 GRIN1 SLC9A6 RHD SLC5A2 ITPR3

2.85e-056276410GO:0022890
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

GABRD SLC5A10 KCNA1 KCNB1 TRPM3 KCNMA1 GRIN1 SLC9A6 SLC5A2 ITPR3

2.00e-047936410GO:0015075
GeneOntologyMolecularFunctionD-glucose:sodium symporter activity

SLC5A10 SLC5A2

2.10e-047642GO:0005412
GeneOntologyMolecularFunctionribosomal protein S6 kinase activity

RPS6KA2 RPS6KA3

2.10e-047642GO:0004711
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC5A10 KCNA1 KCNB1 TRPM3 KCNMA1 GRIN1 SLC9A6 SLC5A2 ITPR3

2.53e-04664649GO:0008324
GeneOntologyMolecularFunctionchannel activity

GABRD KCNA1 KCNB1 TRPM3 KCNMA1 GRIN1 RHD ITPR3

2.63e-04525648GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

GABRD KCNA1 KCNB1 TRPM3 KCNMA1 GRIN1 RHD ITPR3

2.66e-04526648GO:0022803
GeneOntologyMolecularFunctionheme transmembrane transporter activity

ABCC5 SLC48A1

3.59e-049642GO:0015232
GeneOntologyMolecularFunctioncomplement component C1q complex binding

C4A C4B

4.48e-0410642GO:0001849
GeneOntologyMolecularFunctionABC-type transporter activity

ABCA13 ABCC5 ABCC12

5.21e-0449643GO:0140359
GeneOntologyMolecularFunctionmonoatomic ion channel activity

GABRD KCNA1 KCNB1 TRPM3 KCNMA1 GRIN1 ITPR3

6.50e-04459647GO:0005216
GeneOntologyMolecularFunctiongated channel activity

GABRD KCNA1 KCNB1 KCNMA1 GRIN1 ITPR3

6.94e-04334646GO:0022836
GeneOntologyMolecularFunctionmonoatomic cation channel activity

KCNA1 KCNB1 TRPM3 KCNMA1 GRIN1 ITPR3

7.97e-04343646GO:0005261
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC5A10 ABCA13 ABCC5 ABCC12 SLC37A4 SLC9A6 SLC5A2

8.15e-04477647GO:0022804
GeneOntologyMolecularFunctioncarbohydrate derivative transmembrane transporter activity

ABCC5 SLC37A4 SLC5A2

8.98e-0459643GO:1901505
GeneOntologyMolecularFunctioncarbohydrate:monoatomic cation symporter activity

SLC5A10 SLC5A2

1.33e-0317642GO:0005402
GeneOntologyMolecularFunctionGDP-dissociation inhibitor activity

CHM CHML

1.33e-0317642GO:0005092
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

KCNA1 KCNB1 KCNMA1 GRIN1

1.44e-03152644GO:0022843
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

KCNA1 KCNB1 KCNMA1 SLC9A6

2.03e-03167644GO:0015079
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

KCNMA1 GRIN1

2.67e-0324642GO:0099507
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

KCNA1 KCNB1 KCNMA1 GRIN1

2.77e-03182644GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

KCNA1 KCNB1 KCNMA1 GRIN1

2.88e-03184644GO:0022832
GeneOntologyMolecularFunctionopsonin binding

C4A C4B

2.89e-0325642GO:0001846
GeneOntologyMolecularFunctionD-glucose transmembrane transporter activity

SLC5A10 SLC5A2

2.89e-0325642GO:0055056
GeneOntologyMolecularFunctionhexose transmembrane transporter activity

SLC5A10 SLC5A2

2.89e-0325642GO:0015149
GeneOntologyMolecularFunctionmonosaccharide transmembrane transporter activity

SLC5A10 SLC5A2

3.37e-0327642GO:0015145
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

GABRD KCNMA1 GRIN1 ITPR3

3.42e-03193644GO:0015276
GeneOntologyMolecularFunctiondelayed rectifier potassium channel activity

KCNA1 KCNB1

3.62e-0328642GO:0005251
GeneOntologyMolecularFunctionligand-gated channel activity

GABRD KCNMA1 GRIN1 ITPR3

3.68e-03197644GO:0022834
GeneOntologyMolecularFunctionsugar transmembrane transporter activity

SLC5A10 SLC5A2

3.88e-0329642GO:0051119
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

KCNA1 KCNB1 KCNMA1

4.30e-03102643GO:0005249
GeneOntologyMolecularFunctionligand-gated calcium channel activity

GRIN1 ITPR3

4.43e-0331642GO:0099604
GeneOntologyMolecularFunctioncomplement binding

C4A C4B

4.71e-0332642GO:0001848
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ABCA13 ABCC5 ABCC12

5.18e-03109643GO:0042626
GeneOntologyMolecularFunctionprotein domain specific binding

FZD1 FZD4 FZD7 FZD8 KCNA1 CNTNAP4 SYP FZD2

6.64e-03875648GO:0019904
GeneOntologyMolecularFunctionorganophosphate ester transmembrane transporter activity

ABCC5 SLC37A4

6.94e-0339642GO:0015605
GeneOntologyMolecularFunctionfrizzled binding

FZD1 FZD7

8.02e-0342642GO:0005109
GeneOntologyMolecularFunctioncarbohydrate transmembrane transporter activity

SLC5A10 SLC5A2

8.02e-0342642GO:0015144
GeneOntologyMolecularFunctionpotassium channel activity

KCNA1 KCNB1 KCNMA1

8.06e-03128643GO:0005267
GeneOntologyMolecularFunctioncalcium channel activity

TRPM3 GRIN1 ITPR3

8.24e-03129643GO:0005262
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

GABRD SLC5A10 KCNA1 KCNB1 TRPM3 KCNMA1 ABCC5 GRIN1 SLC48A1 SLC37A4 SLC9A6 RHD SLC5A2 ITPR3

2.18e-0610176414GO:0098660
GeneOntologyBiologicalProcessnon-canonical Wnt signaling pathway

FZD1 FZD4 FZD7 FZD8 FZD2

4.08e-0677645GO:0035567
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

SLC5A10 KCNA1 KCNB1 TRPM3 KCNMA1 ABCC5 GRIN1 SLC48A1 SLC9A6 RHD SLC5A2 ITPR3

2.27e-059226412GO:0098662
GeneOntologyBiologicalProcessheme transmembrane transport

ABCC5 SLC48A1

2.84e-053642GO:0035351
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SLC5A10 KCNA1 KCNB1 TRPM3 KCNMA1 ABCC5 GRIN1 SLC48A1 SLC9A6 SLC5A2 ITPR3

1.37e-049426411GO:0098655
GeneOntologyBiologicalProcessmuscular septum morphogenesis

FZD1 FZD2

1.41e-046642GO:0003150
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

GABRD SLC5A10 KCNA1 KCNB1 TRPM3 KCNMA1 ABCC5 GRIN1 SLC48A1 SLC9A6 SLC5A2 ITPR3

1.42e-0411156412GO:0034220
GeneOntologyBiologicalProcessWnt signaling pathway, calcium modulating pathway

FZD4 FZD2

1.97e-047642GO:0007223
GeneOntologyBiologicalProcessmetal ion transport

SLC5A10 KCNA1 KCNB1 TRPM3 KCNMA1 ABCC5 GRIN1 SLC48A1 SLC9A6 SLC5A2 ITPR3

2.31e-0410006411GO:0030001
GeneOntologyBiologicalProcessprotein geranylgeranylation

CHM CHML

2.62e-048642GO:0018344
GeneOntologyBiologicalProcesspositive regulation of apoptotic cell clearance

C4A C4B

2.62e-048642GO:2000427
GeneOntologyBiologicalProcessheme transport

ABCC5 SLC48A1

3.36e-049642GO:0015886
GeneOntologyBiologicalProcesscomplement activation, classical pathway

C4A C4B NCR3LG1

3.45e-0444643GO:0006958
GeneOntologyBiologicalProcessmembranous septum morphogenesis

FZD1 FZD2

4.20e-0410642GO:0003149
GeneOntologyBiologicalProcessregulation of apoptotic cell clearance

C4A C4B

4.20e-0410642GO:2000425
GeneOntologyBiologicalProcesshard palate development

FZD1 FZD2

4.20e-0410642GO:0060022
GeneOntologyBiologicalProcessapoptotic cell clearance

C4A C4B BECN1

4.46e-0448643GO:0043277
GeneOntologyCellularComponentdendrite

FZD4 GABRD KCNA1 KCNB1 KCNMA1 CNTNAP4 C4A C4B GRIN1 BECN1 SLC9A6 ITPR3

1.15e-058586512GO:0030425
GeneOntologyCellularComponentdendritic tree

FZD4 GABRD KCNA1 KCNB1 KCNMA1 CNTNAP4 C4A C4B GRIN1 BECN1 SLC9A6 ITPR3

1.18e-058606512GO:0097447
GeneOntologyCellularComponentcytoplasmic vesicle membrane

FZD4 FZD7 ABCA13 SYP ABCC5 SLC35G2 GRIN1 DCSTAMP SLC48A1 BECN1 FZD2 SLC9A6 SPG21 ITPR3

3.91e-0513076514GO:0030659
GeneOntologyCellularComponentvesicle membrane

FZD4 FZD7 ABCA13 SYP ABCC5 SLC35G2 GRIN1 DCSTAMP SLC48A1 BECN1 FZD2 SLC9A6 SPG21 ITPR3

4.54e-0513256514GO:0012506
GeneOntologyCellularComponentRab-protein geranylgeranyltransferase complex

CHM CHML

5.69e-054652GO:0005968
GeneOntologyCellularComponentapical plasma membrane

SLC5A10 KCNA1 KCNB1 KCNMA1 ABCC5 DRAM2 SLC5A2 ITPR3

1.29e-04487658GO:0016324
GeneOntologyCellularComponentsymbiont cell surface

C4A C4B

2.63e-048652GO:0106139
GeneOntologyCellularComponentother organism part

C4A C4B

3.38e-049652GO:0044217
GeneOntologyCellularComponentsomatodendritic compartment

FZD4 GABRD KCNA1 KCNB1 KCNMA1 CNTNAP4 C4A C4B GRIN1 BECN1 SLC9A6 ITPR3

3.56e-0412286512GO:0036477
GeneOntologyCellularComponentapical part of cell

SLC5A10 KCNA1 KCNB1 KCNMA1 ABCC5 DRAM2 SLC5A2 ITPR3

4.81e-04592658GO:0045177
GeneOntologyCellularComponentaxon terminus

KCNA1 KCNMA1 SYP GRIN1 SLC9A6

4.94e-04210655GO:0043679
GeneOntologyCellularComponentendoplasmic reticulum membrane

SRD5A3 PARP16 MARCHF6 NECAB3 ABCC12 GRIN1 DCSTAMP BECN1 SLC37A4 SLC9A6 RNF133 ITPR3

5.66e-0412936512GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

SRD5A3 PARP16 MARCHF6 NECAB3 ABCC12 GRIN1 DCSTAMP BECN1 SLC37A4 SLC9A6 RNF133 ITPR3

5.90e-0412996512GO:0098827
GeneOntologyCellularComponentpolyprenyl diphosphate synthase complex

CHM CHML

6.16e-0412652GO:0032476
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

SRD5A3 PARP16 MARCHF6 NECAB3 ABCC12 GRIN1 DCSTAMP BECN1 SLC37A4 SLC9A6 RNF133 ITPR3

7.12e-0413276512GO:0042175
GeneOntologyCellularComponentneuron projection terminus

KCNA1 KCNMA1 SYP GRIN1 SLC9A6

7.90e-04233655GO:0044306
GeneOntologyCellularComponentaxon

GABRD KCNA1 KCNB1 KCNMA1 SYP C4A C4B GRIN1 SLC9A6

1.67e-03891659GO:0030424
GeneOntologyCellularComponentpresynaptic membrane

KCNA1 KCNMA1 CNTNAP4 SYP GRIN1

1.70e-03277655GO:0042734
GeneOntologyCellularComponentsynaptic membrane

GABRD KCNA1 KCNB1 KCNMA1 CNTNAP4 SYP GRIN1

2.17e-03583657GO:0097060
GeneOntologyCellularComponentendosome membrane

FZD7 ABCC5 DCSTAMP SLC48A1 BECN1 SLC9A6 SPG21

2.60e-03602657GO:0010008
GeneOntologyCellularComponentvoltage-gated potassium channel complex

KCNA1 KCNB1 KCNMA1

2.87e-0391653GO:0008076
GeneOntologyCellularComponentterminal bouton

KCNMA1 SYP GRIN1

3.34e-0396653GO:0043195
GeneOntologyCellularComponentpotassium channel complex

KCNA1 KCNB1 KCNMA1

4.18e-03104653GO:0034705
GeneOntologyCellularComponentneuronal cell body

GABRD KCNA1 KCNB1 KCNMA1 C4A C4B GRIN1 ITPR3

4.23e-03835658GO:0043025
DomainFrizzled

FZD1 FZD4 FZD7 FZD8 FZD2

1.98e-1011655IPR000539
DomainFrizzled

FZD1 FZD4 FZD7 FZD8 FZD2

1.98e-1011655PF01534
DomainFrizzled

FZD1 FZD4 FZD7 FZD8 FZD2

1.98e-1011655SM01330
DomainFrizzled/SFRP

FZD1 FZD4 FZD7 FZD8 FZD2

1.85e-0916655IPR015526
DomainFRI

FZD1 FZD4 FZD7 FZD8 FZD2

6.50e-0920655SM00063
Domain-

FZD1 FZD4 FZD7 FZD8 FZD2

8.51e-09216551.10.2000.10
DomainFrizzled_dom

FZD1 FZD4 FZD7 FZD8 FZD2

1.76e-0824655IPR020067
DomainFZ

FZD1 FZD4 FZD7 FZD8 FZD2

1.76e-0824655PS50038
DomainFz

FZD1 FZD4 FZD7 FZD8 FZD2

1.76e-0824655PF01392
DomainGPCR_2_secretin-like

FZD1 FZD4 FZD7 FZD8 FZD2

2.06e-0660655IPR000832
DomainGPCR_2-like

FZD1 FZD4 FZD7 FZD8 FZD2

2.06e-0660655IPR017981
DomainG_PROTEIN_RECEP_F2_4

FZD1 FZD4 FZD7 FZD8 FZD2

2.23e-0661655PS50261
DomainRab_escort

CHM CHML

1.19e-052652IPR001738
DomainIon_trans_dom

KCNA1 KCNB1 TRPM3 KCNMA1 ITPR3

4.78e-05114655IPR005821
DomainIon_trans

KCNA1 KCNB1 TRPM3 KCNMA1 ITPR3

4.78e-05114655PF00520
DomainGDI

CHM CHML

7.12e-054652PF00996
DomainGDP_dissociation_inhibitor

CHM CHML

7.12e-054652IPR018203
DomainAnaphylatoxin_comp_syst

C4A C4B

1.18e-045652IPR018081
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

1.18e-045652IPR001840
DomainRibosomal_S6_kinase_II

RPS6KA2 RPS6KA3

1.77e-046652IPR016239
DomainVG_K_chnl

KCNA1 KCNB1 KCNMA1

2.04e-0433653IPR028325
DomainANATO

C4A C4B

2.48e-047652SM00104
DomainANATO

C4A C4B

2.48e-047652PF01821
DomainANAPHYLATOXIN_2

C4A C4B

2.48e-047652PS01178
DomainANAPHYLATOXIN_1

C4A C4B

2.48e-047652PS01177
DomainAnaphylatoxin/fibulin

C4A C4B

2.48e-047652IPR000020
DomainThiol-ester_cl

C4A C4B

3.29e-048652PF10569
DomainMacrogloblnA2_thiol-ester-bond

C4A C4B

3.29e-048652IPR019565
DomainNa/solute_symporter_CS

SLC5A10 SLC5A2

3.29e-048652IPR018212
DomainMacrogloblnA2_CS

C4A C4B

3.29e-048652IPR019742
DomainA2M_N

C4A C4B

5.27e-0410652PF01835
DomainA2M_N

C4A C4B

5.27e-0410652IPR002890
DomainA-macroglobulin_rcpt-bd

C4A C4B

5.27e-0410652IPR009048
DomainALPHA_2_MACROGLOBULIN

C4A C4B

5.27e-0410652PS00477
DomainA2M

C4A C4B

5.27e-0410652PF00207
DomainA2M_N_2

C4A C4B

5.27e-0410652IPR011625
DomainA2M_comp

C4A C4B

5.27e-0410652IPR011626
DomainA2M_N_2

C4A C4B

5.27e-0410652PF07703
DomainA2M_recep

C4A C4B

5.27e-0410652PF07677
DomainA2M_comp

C4A C4B

5.27e-0410652PF07678
DomainMacroglobln_a2

C4A C4B

5.27e-0410652IPR001599
DomainABC_tran

ABCA13 ABCC5 ABCC12

6.22e-0448653PF00005
DomainABC_TRANSPORTER_2

ABCA13 ABCC5 ABCC12

6.22e-0448653PS50893
DomainABC_TRANSPORTER_1

ABCA13 ABCC5 ABCC12

6.61e-0449653PS00211
DomainABC_transporter-like

ABCA13 ABCC5 ABCC12

7.02e-0450653IPR003439
DomainNA_SOLUT_SYMP_2

SLC5A10 SLC5A2

7.70e-0412652PS00457
DomainSSF

SLC5A10 SLC5A2

7.70e-0412652PF00474
DomainNa/solute_symporter

SLC5A10 SLC5A2

7.70e-0412652IPR001734
DomainNA_SOLUT_SYMP_3

SLC5A10 SLC5A2

7.70e-0412652PS50283
DomainC345C

C4A C4B

1.57e-0317652SM00643
DomainAAA+_ATPase

ABCA13 ABCC5 ABCC12 DNAH5

1.59e-03144654IPR003593
DomainAAA

ABCA13 ABCC5 ABCC12 DNAH5

1.59e-03144654SM00382
DomainTerpenoid_cyclase/PrenylTrfase

C4A C4B

1.76e-0318652IPR008930
DomainNTR

C4A C4B

1.96e-0319652PF01759
DomainNetrin_module_non-TIMP

C4A C4B

1.96e-0319652IPR018933
DomainNTR

C4A C4B

2.88e-0323652PS50189
DomainNetrin_domain

C4A C4B

2.88e-0323652IPR001134
DomainABC_membrane

ABCC5 ABCC12

3.13e-0324652PF00664
DomainTIMP-like_OB-fold

C4A C4B

3.67e-0326652IPR008993
DomainK_chnl_volt-dep_Kv

KCNA1 KCNB1

3.96e-0327652IPR003968
DomainABC_TM1F

ABCC5 ABCC12

4.25e-0328652PS50929
DomainABC1_TM_dom

ABCC5 ABCC12

4.25e-0328652IPR011527
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_SOST_LRP4

FZD1 FZD4 FZD7 FZD8 FZD2

9.90e-1014515M47834
PathwayKEGG_MEDICUS_REFERENCE_WNT5A_ROR_SIGNALING_PATHWAY

FZD1 FZD4 FZD7 FZD8 FZD2

2.15e-0916515M47823
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_LGR_RSPO

FZD1 FZD4 FZD7 FZD8 FZD2

5.67e-0919515M47833
PathwayPID_WNT_SIGNALING_PATHWAY

FZD1 FZD4 FZD7 FZD8 FZD2

4.68e-0828515M77
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

FZD1 FZD4 FZD7 FZD8 FZD2

1.76e-0736515M39699
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

FZD1 FZD4 FZD7 FZD8 FZD2

4.95e-0744515MM15878
PathwayKEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

FZD1 FZD4 FZD7 FZD8 FZD2

5.55e-0745515M47412
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY

FZD1 FZD4 FZD7 FZD8 FZD2

6.21e-0746515M47409
PathwayKEGG_BASAL_CELL_CARCINOMA

FZD1 FZD4 FZD7 FZD8 FZD2

1.54e-0655515M17807
PathwayREACTOME_ASYMMETRIC_LOCALIZATION_OF_PCP_PROTEINS

FZD1 FZD4 FZD7 FZD8 FZD2

2.38e-0660515MM15150
PathwayREACTOME_ASYMMETRIC_LOCALIZATION_OF_PCP_PROTEINS

FZD1 FZD4 FZD7 FZD8 FZD2

3.29e-0664515M27396
PathwayWP_PHYSICOCHEMICAL_FEATURES_AND_TOXICITYASSOCIATED_PATHWAYS

FZD1 FZD4 FZD7 FZD8 FZD2

3.84e-0666515M39642
PathwayREACTOME_PCP_CE_PATHWAY

FZD1 FZD4 FZD7 FZD8 FZD2

1.34e-0585515MM15041
PathwayWP_POLYCYSTIC_KIDNEY_DISEASE_PATHWAY

FZD1 FZD4 FZD7 FZD8 FZD2

1.34e-0585515M48315
PathwayREACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING

FZD1 FZD4 FZD7 FZD8 FZD2 ITPR3

1.37e-05146516M27288
PathwayWNT_SIGNALING

FZD1 FZD4 FZD7 FZD8 FZD2

1.67e-0589515M5493
PathwayREACTOME_PCP_CE_PATHWAY

FZD1 FZD4 FZD7 FZD8 FZD2

1.97e-0592515M27322
PathwayREACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS

FZD1 FZD4 FZD7 FZD8 FZD2

2.18e-0594515M797
PathwayWP_REGULATION_OF_WNT_BCATENIN_SIGNALING_BY_SMALL_MOLECULE_COMPOUNDS

FZD1 FZD7 FZD8

2.93e-0517513M39525
PathwayKEGG_MELANOGENESIS

FZD1 FZD4 FZD7 FZD8 FZD2

3.09e-05101515M7761
PathwayWP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY

FZD1 FZD4 FZD7 FZD8 FZD2

3.09e-05101515MM15829
PathwayWP_WNT_SIGNALING_AND_PLURIPOTENCY

FZD1 FZD4 FZD7 FZD8 FZD2

3.09e-05101515M39387
PathwayWP_ALZHEIMERS_DISEASE

FZD1 FZD7 FZD8 GRIN1 BECN1 FZD2 ITPR3

3.97e-05261517M42565
PathwayWP_WNT_SIGNALING_PATHWAY

FZD1 FZD4 FZD7 FZD8 FZD2

4.66e-05110515MM15977
PathwayWP_ESC_PLURIPOTENCY_PATHWAYS

FZD1 FZD4 FZD7 FZD8 FZD2

6.01e-05116515MM15863
PathwayWP_EMBRYONIC_STEM_CELL_PLURIPOTENCY_PATHWAYS

FZD1 FZD4 FZD7 FZD8 FZD2

6.26e-05117515M39530
PathwayWP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES

FZD1 FZD4 FZD7 FZD8 FZD2

6.52e-05118515M39852
PathwayWP_WNT_SIGNALING

FZD1 FZD7 FZD8 FZD2

6.81e-0561514MM15893
PathwayREACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING

FZD1 FZD4 FZD7 FZD8 FZD2

7.94e-05123515MM14988
PathwayKEGG_LONG_TERM_POTENTIATION

RPS6KA2 RPS6KA3 GRIN1 ITPR3

1.17e-0470514M3115
PathwayREACTOME_CREB1_PHOSPHORYLATION_THROUGH_NMDA_RECEPTOR_MEDIATED_ACTIVATION_OF_RAS_SIGNALING

RPS6KA2 RPS6KA3

1.27e-045512MM15108
PathwayREACTOME_CREB1_PHOSPHORYLATION_THROUGH_NMDA_RECEPTOR_MEDIATED_ACTIVATION_OF_RAS_SIGNALING

RPS6KA2 RPS6KA3 GRIN1

1.37e-0428513M837
PathwayWP_ALZHEIMERS_DISEASE_AND_MIRNA_EFFECTS

FZD1 FZD7 FZD8 GRIN1 BECN1 FZD2 ITPR3

1.60e-04326517M39379
PathwayKEGG_MEDICUS_REFERENCE_ERK_RSK_SIGNALING

RPS6KA2 RPS6KA3

1.91e-046512M47936
PathwayKEGG_WNT_SIGNALING_PATHWAY

FZD1 FZD4 FZD7 FZD8 FZD2

2.08e-04151515M19428
PathwayREACTOME_RSK_ACTIVATION

RPS6KA2 RPS6KA3

2.66e-047512M27369
PathwayREACTOME_ACTIVATION_OF_C3_AND_C5

C4A C4B

2.66e-047512MM14685
PathwayREACTOME_CREB_PHOSPHORYLATION

RPS6KA2 RPS6KA3

2.66e-047512M27096
PathwayREACTOME_CREB_PHOSPHORYLATION

RPS6KA2 RPS6KA3

2.66e-047512MM14784
PathwayREACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS

RPS6KA2 RPS6KA3 GRIN1

2.69e-0435513MM15109
PathwayWP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER

FZD1 FZD4 FZD7 FZD8 FZD2

2.81e-04161515M39770
PathwaySIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES

RPS6KA2 RPS6KA3 ITPR3

2.93e-0436513M1315
PathwayWP_NCRNAS_INVOLVED_IN_WNT_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA

FZD1 FZD7 FZD8 FZD2

2.96e-0489514M39563
PathwayREACTOME_SIGNALING_BY_RNF43_MUTANTS

FZD4 FZD8

3.54e-048512M27433
PathwayREACTOME_ACTIVATION_OF_C3_AND_C5

C4A C4B

3.54e-048512M27031
PathwayKEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION

C4A C4B

3.54e-048512M47872
PathwayWP_LNCRNA_IN_CANONICAL_WNT_SIGNALING_AND_COLORECTAL_CANCER

FZD1 FZD7 FZD8 FZD2

4.27e-0498514M39731
PathwayKEGG_ABC_TRANSPORTERS

ABCA13 ABCC5 ABCC12

5.32e-0444513M11911
PathwayBIOCARTA_LECTIN_PATHWAY

C4A C4B

6.91e-0411512MM1430
PathwayKEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION

C4A C4B

6.91e-0411512M47874
PathwayWP_WNT_SIGNALING_WP428

FZD1 FZD7 FZD8 FZD2

7.32e-04113514M39669
PathwayBIOCARTA_CLASSIC_PATHWAY

C4A C4B

8.28e-0412512MM1368
PathwayWP_PLEURAL_MESOTHELIOMA

FZD1 FZD7 FZD8 RPS6KA3 BECN1 FZD2 ITPR3

9.59e-04439517M42563
PathwayBIOCARTA_LECTIN_PATHWAY

C4A C4B

9.76e-0413512M4732
PathwayREACTOME_SIGNALING_BY_WNT

FZD1 FZD4 FZD7 FZD8 FZD2 ITPR3

1.17e-03330516M7847
PathwayREACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS

RPS6KA2 RPS6KA3

1.31e-0315512MM15103
PathwayBIOCARTA_CLASSIC_PATHWAY

C4A C4B

1.31e-0315512M7146
PathwayREACTOME_CA2_PATHWAY

FZD4 FZD2 ITPR3

1.45e-0362513M27321
PathwayREACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK

RPS6KA2 RPS6KA3

1.49e-0316512MM15477
PathwayREACTOME_SIGNALING_BY_WNT

FZD1 FZD4 FZD7 FZD8 FZD2

1.67e-03239515MM14756
PathwayWP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY

C4A C4B

1.69e-0317512MM15944
PathwayBIOCARTA_COMP_PATHWAY

C4A C4B

1.69e-0317512MM1369
PathwayREACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK

RPS6KA2 RPS6KA3

1.89e-0318512M657
PathwayKEGG_COMPLEMENT_AND_COAGULATION_CASCADES

C4A C4B PROC

1.98e-0369513M16894
PathwayWP_ADHD_AND_AUTISM_ASD_PATHWAYS

GABRD KCNA1 CNTNAP4 SYP GRIN1 BECN1

2.00e-03367516M48346
PathwayREACTOME_CELLULAR_HEXOSE_TRANSPORT

SLC5A10 SLC5A2

2.11e-0319512MM14718
PathwayKEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY

ZAP70 ITPR3

2.11e-0319512M47733
PathwayREACTOME_ERK_MAPK_TARGETS

RPS6KA2 RPS6KA3

2.11e-0319512MM14780
PathwayWP_BREAST_CANCER_PATHWAY

FZD1 FZD7 FZD8 FZD2

2.30e-03154514M39739
PathwayREACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION

FZD4 FZD8

2.34e-0320512MM15155
PathwayBIOCARTA_COMP_PATHWAY

C4A C4B

2.34e-0320512M917
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

FZD1 FZD4 FZD8 FZD2

2.52e-03158514MM14791
PathwayREACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION

FZD4 FZD8

2.58e-0321512M27401
PathwayREACTOME_CELLULAR_HEXOSE_TRANSPORT

SLC5A10 SLC5A2

2.58e-0321512M27058
PathwayWP_GPCRS_NONODORANT

FZD1 FZD4 FZD7 FZD8 FZD2

2.67e-03266515MM15843
PathwayWP_COMPLEMENT_ACTIVATION

C4A C4B

2.83e-0322512M39502
PathwayREACTOME_ERK_MAPK_TARGETS

RPS6KA2 RPS6KA3

2.83e-0322512M13408
PathwayWP_CLOCKCONTROLLED_AUTOPHAGY_IN_BONE_METABOLISM

DRAM2 BECN1 CRY1

3.01e-0380513M45523
PathwayREACTOME_SIGNALING_BY_GPCR

FZD1 FZD4 FZD7 FZD8 RPS6KA2 RPS6KA3 FZD2 ITPR3

3.46e-03702518M746
PathwayREACTOME_NEURONAL_SYSTEM

KCNA1 KCNB1 RPS6KA2 RPS6KA3 KCNMA1 GRIN1

3.52e-03411516M735
PathwayREACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION

RPS6KA2 RPS6KA3

4.25e-0327512MM14779
PathwayREACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES

RPS6KA2 RPS6KA3

4.57e-0328512MM15132
PathwayREACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS

RPS6KA2 RPS6KA3 GRIN1

4.74e-0394513M2843
PathwayWP_GPCRS_OTHER

FZD1 FZD7 FZD2

5.03e-0396513MM15939
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

FZD1 FZD2

5.58e-0331512M27400
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

FZD1 FZD2

5.58e-0331512MM15154
PathwayREACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES

RPS6KA2 RPS6KA3

5.58e-0331512M15195
PathwayPID_WNT_NONCANONICAL_PATHWAY

FZD7 FZD2

5.94e-0332512M23
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

KCNB1 ITPR3

5.94e-0332512MM14983
PathwayREACTOME_POTASSIUM_CHANNELS

KCNA1 KCNB1 KCNMA1

6.12e-03103513M1073
PathwayKEGG_PATHWAYS_IN_CANCER

FZD1 FZD4 FZD7 FZD8 FZD2

6.23e-03325515M12868
Pubmed

Expression of Frizzled genes in developing and postnatal hair follicles.

FZD1 FZD4 FZD7 FZD8 FZD2

5.27e-121066515245425
Pubmed

Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis.

FZD1 FZD4 FZD7 FZD8 FZD2

5.27e-121066517532316
Pubmed

Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.

FZD1 FZD4 FZD7 FZD8 FZD2

9.65e-121166524860427
Pubmed

Molecular determinants of WNT9b responsiveness in nephron progenitor cells.

FZD1 FZD4 FZD7 FZD8 FZD2

9.65e-121166530978219
Pubmed

Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain.

FZD1 FZD4 FZD7 FZD8 FZD2

9.65e-121166517582687
Pubmed

Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling.

FZD1 FZD4 FZD7 FZD8 FZD2

9.65e-121166517576136
Pubmed

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

FZD1 FZD4 FZD7 FZD8 FZD2

1.28e-101766528733458
Pubmed

Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).

FZD1 FZD4 FZD7 FZD8

4.12e-10766415370539
Pubmed

Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.

FZD1 FZD4 FZD7 FZD8 FZD2

5.42e-102266517064353
Pubmed

Differential expression of the Wnt putative receptors Frizzled during mouse somitogenesis.

FZD1 FZD4 FZD7 FZD8

8.23e-10866410559494
Pubmed

Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.

FZD1 FZD4 FZD7 FZD2

8.23e-10866419388021
Pubmed

A role for Wnt/beta-catenin signaling in lens epithelial differentiation.

FZD1 FZD4 FZD7 FZD8 FZD2

1.09e-092566512812787
Pubmed

Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.

FZD1 FZD4 FZD7 FZD2

1.48e-09966412067714
Pubmed

A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.

FZD1 FZD4 FZD7 FZD2

1.48e-0996649707618
Pubmed

3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).

FZD1 FZD4 FZD7 FZD8 FZD2

2.42e-092966518364260
Pubmed

Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.

FZD1 FZD7 FZD2

6.53e-0936639813155
Pubmed

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.

FZD1 FZD7 FZD2

6.53e-09366327680706
Pubmed

Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.

FZD1 FZD4 FZD7 FZD8 FZD2

7.60e-093666524151333
Pubmed

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.

FZD1 FZD4 FZD7 FZD8 FZD2

8.77e-093766515342465
Pubmed

Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis.

FZD1 FZD4 FZD7 FZD8 FZD2

8.77e-093766518800919
Pubmed

Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals.

FZD1 FZD4 FZD7 FZD8 FZD2

1.01e-083866521041481
Pubmed

Tissue-specific requirements of beta-catenin in external genitalia development.

FZD1 FZD4 FZD7 FZD8 FZD2

1.01e-083866518635608
Pubmed

Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.

FZD1 FZD4 FZD7 FZD8 FZD2

3.04e-084766528813421
Pubmed

Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.

FZD1 FZD4 FZD7 FZD8 FZD2

3.04e-084766518351675
Pubmed

Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.

FZD1 FZD4 FZD7 FZD8 FZD2

3.04e-084766533141892
Pubmed

Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells.

FZD1 FZD4 FZD7 FZD8 FZD2

3.77e-084966519562671
Pubmed

Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling.

FZD1 FZD4 FZD7 FZD8 FZD2

4.18e-085066527510977
Pubmed

Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.

FZD1 FZD7 FZD8 FZD2

4.49e-081966421623369
Pubmed

Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner.

FZD4 FZD7 FZD8

6.51e-08566310395542
Pubmed

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.

FZD4 FZD7 FZD8 FZD2

1.22e-07246649096311
Pubmed

A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.

FZD4 FZD7 FZD8 FZD2

1.22e-07246648626800
Pubmed

Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling.

FZD4 FZD7 FZD2

1.30e-07666320802536
Pubmed

FZD2 regulates limb development by mediating β-catenin-dependent and -independent Wnt signaling pathways.

FZD1 FZD7 FZD2

1.30e-07666336867021
Pubmed

MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap.

FZD4 FZD7 FZD8

2.27e-07766315195140
Pubmed

Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5.

FZD1 FZD4 FZD7

2.27e-07766315923619
Pubmed

Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes.

FZD1 FZD7 FZD2

5.44e-07966323095888
Pubmed

Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation.

FZD4 FZD7 FZD8 FZD2

6.65e-073666412412008
Pubmed

Integrated analysis of Wnt signalling system component gene expression.

FZD1 FZD4 FZD7 FZD8

7.45e-073766435831952
Pubmed

Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.

FZD1 FZD4 FZD7 FZD8 FZD2

8.18e-079066519515997
Pubmed

Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development.

FZD1 FZD7 FZD2

1.84e-061366321246654
Pubmed

WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth.

FZD1 FZD4 FZD8 FZD2

2.55e-065066418351662
Pubmed

Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung.

FZD7 FZD8 FZD2

2.92e-061566315617677
Pubmed

Mapping of 12 markers in the proximal region of mouse chromosome 17 using recombinant t haplotypes.

C4A C4B ITPR3

2.92e-06156637749235
Pubmed

PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.

FZD1 FZD4 FZD7 FZD8 FZD2

3.00e-0611766517145500
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

3.55e-06266222737222
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

3.55e-06266216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

3.55e-06266215998580
Pubmed

Structural polymorphism of murine C4 and its linkage to H-2.

C4A C4B

3.55e-0626627373044
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

3.55e-06266219062096
Pubmed

The chemical structure of the C4d fragment of the human complement component C4.

C4A C4B

3.55e-0626623696167
Pubmed

Molecular interaction and functional coupling between type 3 inositol 1,4,5-trisphosphate receptor and BKCa channel stimulate breast cancer cell proliferation.

KCNMA1 ITPR3

3.55e-06266223992640
Pubmed

Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.

C4A C4B

3.55e-0626621357031
Pubmed

Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.

C4A C4B

3.55e-06266216098595
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

3.55e-06266219933335
Pubmed

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

C4A C4B

3.55e-0626622459207
Pubmed

Antigen-induced B cell apoptosis is independent of complement C4.

C4A C4B

3.55e-06266217645767
Pubmed

Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.

C4A C4B

3.55e-06266215787745
Pubmed

Anti-DNA autoreactivity in C4-deficient mice.

C4A C4B

3.55e-06266212207352
Pubmed

Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.

C4A C4B

3.55e-06266230026462
Pubmed

A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.

C4A C4B

3.55e-0626626559257
Pubmed

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

C4A C4B

3.55e-06266227758680
Pubmed

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

C4A C4B

3.55e-06266222387014
Pubmed

Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.

C4A C4B

3.55e-06266234299197
Pubmed

Assessment of complement C4 gene copy number using the paralog ratio test.

C4A C4B

3.55e-06266220506482
Pubmed

Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.

C4A C4B

3.55e-06266212480675
Pubmed

Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.

C4A C4B

3.55e-06266226800705
Pubmed

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.

C4A C4B

3.55e-06266223749435
Pubmed

Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.

C4A C4B

3.55e-06266223918728
Pubmed

MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function.

ABCC5 ABCC12

3.55e-06266235121660
Pubmed

Murine complement C4 is not required for experimental autoimmune encephalomyelitis.

C4A C4B

3.55e-06266215390104
Pubmed

Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.

C4A C4B

3.55e-0626623037333
Pubmed

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

C4A C4B

3.55e-06266211726230
Pubmed

Mouse choroideremia gene mutation causes photoreceptor cell degeneration and is not transmitted through the female germline.

CHM CHML

3.55e-0626629175730
Pubmed

Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

C4A C4B

3.55e-0626624216347
Pubmed

Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.

C4A C4B

3.55e-0626621699796
Pubmed

Sequence determination of the thiolester site of the fourth component of human complement.

C4A C4B

3.55e-0626626950384
Pubmed

Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.

C4A C4B

3.55e-0626622997024
Pubmed

Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.

C4A C4B

3.55e-0626628660986
Pubmed

Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.

C4A C4B

3.55e-0626623624865
Pubmed

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

C4A C4B

3.55e-0626628428773
Pubmed

Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.

C4A C4B

3.55e-06266221857912
Pubmed

Melanocyte stem cells express receptors for canonical Wnt-signaling pathway on their surface.

FZD4 FZD7

3.55e-06266220450888
Pubmed

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.

C4A C4B

3.55e-06266224638111
Pubmed

Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.

C4A C4B

3.55e-0626626208559
Pubmed

The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.

C4A C4B

3.55e-0626624514997
Pubmed

Transcriptional repression of C4 complement by hepatitis C virus proteins.

C4A C4B

3.55e-06266221345967
Pubmed

The inheritance of susceptibility to the Gross leukemia virus in mice.

C4A C4B

3.55e-0626625919331
Pubmed

An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.

C4A C4B

3.55e-0626623167981
Pubmed

The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.

C4A C4B

3.55e-0626627545960
Pubmed

Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.

C4A C4B

3.55e-06266230041577
Pubmed

Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

C4A C4B

3.55e-0626622572548
Pubmed

The complement component C4 of mammals.

C4A C4B

3.55e-0626622302180
Pubmed

Complete cDNA sequence of the fourth component of murine complement.

C4A C4B

3.55e-0626623862104
Pubmed

The BS variant of C4 protects against age-related loss of white matter microstructural integrity.

C4A C4B

3.55e-06266234358307
Pubmed

Cloning and characterization of the human choroideremia gene.

CHM CHML

3.55e-0626627981670
Pubmed

Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.

C4A C4B

3.55e-06266218360261
Pubmed

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

C4A C4B

3.55e-06266222151770
Pubmed

C4d-positive chronic rejection: a frequent entity with a poor outcome.

C4A C4B

3.55e-06266218091514
Pubmed

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.

C4A C4B

3.55e-06266229080553
Pubmed

Schizophrenia risk from complex variation of complement component 4.

C4A C4B

3.55e-06266226814963
InteractionWNT5A interactions

FZD1 FZD4 FZD2 PROC CLEC12B

2.86e-0669655int:WNT5A
InteractionSCGB1C1 interactions

FZD1 FZD7 FZD2

8.95e-0613653int:SCGB1C1
InteractionRAB26 interactions

SYP CHM CHML

2.99e-0519653int:RAB26
InteractionRASEF interactions

CHM CHML ITPR3

7.00e-0525653int:RASEF
InteractionOR1D4 interactions

FZD7 FZD8 FZD2

7.90e-0526653int:OR1D4
GeneFamilyG protein-coupled receptors, Class F frizzled

FZD1 FZD4 FZD7 FZD8 FZD2

6.66e-1111515286
GeneFamilyGlycosyltransferase family 6|Blood group antigens

C4A C4B RHD

1.54e-0437513454
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

C4A C4B

2.77e-0495121234
GeneFamilyMitogen-activated protein kinase-activated protein kinases

RPS6KA2 RPS6KA3

4.22e-04115121156
GeneFamilyATP binding cassette subfamily C

ABCC5 ABCC12

5.97e-0413512807
GeneFamilySolute carriers

SLC5A10 SLC35G2 SLC48A1 SLC37A4 SLC9A6 SLC5A2

8.22e-04395516752
GeneFamilyComplement system|Sushi domain containing

C4A C4B

4.62e-0336512492
GeneFamilyPotassium voltage-gated channels

KCNA1 KCNB1

5.68e-0340512274
GeneFamilyC-type lectin domain family

KLRF1 CLEC12B

7.78e-0347512494
GeneFamilyX-linked mental retardation|Angiotensin receptors

RPS6KA3 SYP

9.81e-0353512103
DrugA 172

FZD1 FZD4 FZD7 FZD8 FZD2

1.70e-0670655CID000014025
Drugclofazimine

FZD1 FZD4 FZD7 FZD2

2.96e-0635654CID000002794
DrugAC1L9M5J

FZD1 FZD4 FZD7 FZD8 RPS6KA2 SYP FZD2

3.19e-06221657CID000448615
Drugs-nitrosodithiothreitol

KCNA1 KCNB1

8.03e-062652CID000194511
Drugsodium

GABRD SLC5A10 KCNA1 KCNB1 TRPM3 KCNMA1 POLG2 CHKB SLC9A6 PROC CA5A SLC5A2

1.28e-059446512CID000000923
DrugPrestwick_517

FZD1 FZD4 FZD7 FZD8 FZD2

1.32e-05106655CID000003804
Drug2-aminothiophenol

C4A C4B

2.40e-053652ctd:C005464
Drugrubidium

KCNB1 KCNMA1 CHKB SLC9A6

2.79e-0561654CID000105153
Diseasechoroideremia (implicated_via_orthology)

CHM CHML

4.49e-062632DOID:9821 (implicated_via_orthology)
DiseaseCoffin-Lowry syndrome (implicated_via_orthology)

RPS6KA2 RPS6KA3

2.68e-054632DOID:3783 (implicated_via_orthology)
Diseasesystemic lupus erythematosus (implicated_via_orthology)

C4A C4B BECN1

1.08e-0443633DOID:9074 (implicated_via_orthology)
DiseaseAntibody Deficiency Syndrome

C4A ZAP70

5.98e-0417632C0003257
DiseaseImmunologic Deficiency Syndromes

C4A ZAP70

1.10e-0323632C0021051
DiseaseMyopia

TRPM3 KCNMA1 CNTNAP4 BTBD17 CHKB

1.39e-03385635HP_0000545
Diseaseintellectual disability (is_implicated_in)

RPS6KA3 CHKB

1.88e-0330632DOID:1059 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
AMWSGLFTHLTESWN

ARSK

86

Q6UWY0
MRLLWGLIWASSFFT

C4B

1

P0C0L5
LSVQTWWTALGFKAM

CTSL3P

96

Q5NE16
SWGSFWAMLTLVGLV

BTBD17

11

A6NE02
VTSYLLMFSDSGWNW

CNTNAP4

106

Q9C0A0
TFGWVCWMILFDSSL

ABCA13

3751

Q86UQ4
FFWGLWSILQASMST

CHKB

351

Q9Y259
VYPLTMTWSFGWNSS

CFAP251

246

Q8TBY9
NWASFSFSGLLSWLK

CHM

46

P24386
NWASFSFSGLLSWLK

CHML

46

P26374
WFSRRMTLWGSISFN

ITPR3

2196

Q14573
FSSIPDAFWWAVVSM

KCNA1

356

Q09470
MWWAFLASSMVTFFG

KCNMA1

86

Q12791
TQSADWWSFGVLMFE

RPS6KA3

246

P51812
LNITSMGITWFWKSL

NCR3LG1

56

Q68D85
FMLTNLKWGLAWVSS

BECN1

431

Q14457
WLLGDSSFFLRTWLM

HARBI1

221

Q96MB7
SSALVNTGLWFMQKW

FAM135A

1366

Q9P2D6
NITWMANHTGWSDFI

OR2T4

31

Q8NH00
STFWALMVGCWFASV

NEMP2

206

A6NFY4
MGIWTSGTDIFLSLW

DCSTAMP

1

Q9H295
MWWFQQGLSFLPSAL

DRAM2

1

Q6UX65
FFSMASSIWWVILSL

FZD2

336

Q14332
VFAGRWLMSFWTGTA

MARCHF6

656

O60337
QWWRKFAMSPSNFSS

POLG2

261

Q9UHN1
LVAMSWVSFWISQAA

GABRD

261

O14764
WALSLWPGFTDTFNM

ITGA11

11

Q9UKX5
LFLEWVMVAWNSISS

POGK

546

Q9P215
LSSVWSFISFKWAFL

SLC48A1

111

Q6P1K1
SQLSWFSSHWFTVMI

PARP16

281

Q8N5Y8
MWQLTSLLLFVATWG

PROC

1

P04070
MAVTFGFHNLTWWLV

SRD5A3

266

Q9H8P0
FMLNVGSTAFSTWWL

ABCC5

866

O15440
TWKTSAFSFLVEQMW

CA5A

6

P35218
FFSMASSIWWVILSL

FZD1

411

Q9UP38
FFGMASSIWWVILTL

FZD4

311

Q9ULV1
FGMASSIWWVILSLT

FZD7

346

O75084
FGMASSIWWVILSLT

FZD8

406

Q9H461
PSQFGTWWAILSTSM

SLC37A4

131

O43826
VWIGLNFTSLKMTWT

KLRF1

171

Q9NZS2
NFTSLKMTWTWVDGS

KLRF1

176

Q9NZS2
FKSIPASFWWATITM

KCNB1

361

Q14721
WIFSIAWISDTMAVS

DCAF12

186

Q5T6F0
SINAGSWMWLSCSSF

CRY1

391

Q16526
MRLLWGLIWASSFFT

C4A

1

P0C0L4
KASWISSTLGFWFTE

DNAH5

4446

Q8TE73
WLNIGMVFSTSCWSR

JARID2

916

Q92833
ALSSHWFFTWVGLEM

MT-ND2

21

P03891
TAVFAFMWLVSSSAW

SYP

146

P08247
FMWLVSSSAWAKGLS

SYP

151

P08247
NNTASSWLMKFSVLW

RNF133

11

Q8WVZ7
MSWSTFLLAEAWGFT

SLC9A6

336

Q92581
KISMWTALFTFGWTG

SLC35G2

281

Q8TBE7
ISNTWLSTGWFTMTI

ST6GALNAC5

226

Q9BVH7
SIFNQTWTANSFWLM

SPG21

141

Q9NZD8
LFLLMIGSAAFSNWW

ABCC12

801

Q96J65
LLMFSFFWLGLSWDS

CLEC12B

196

Q2HXU8
LTGSVMGTEWTLWVF

TRIML2

341

Q8N7C3
FSSRSDVWSYGVTMW

ZAP70

516

P43403
LWMFWPSFNSALLRS

RHD

216

Q02161
KNWSFVWSTLGVTAM

SPNS3

256

Q6ZMD2
SMVWWPVGASLFASN

SLC5A2

61

P31639
DMTWWPIGASLFASS

SLC5A10

56

A0PJK1
VFSFLFSWWNLEGVM

TRPM3

16

Q9HCF6
NTFTGRWLTRFQAMW

WDR76

541

Q9H967
WGLLSFKDISMEFTW

ZNF26

11

P17031
NSSHWTEFLWFIQMS

ZBED9

491

Q6R2W3
HTQSADWWSFGVLMF

RPS6KA2

236

Q15349
LTLSSAMWFSWGVLL

GRIN1

601

Q05586
LTTVFFPASWWIMNN

NECAB3

381

Q96P71