Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

STAB2 LDLR STAB1 LRP1 LRP2 SORL1

2.02e-09161636GO:0005041
GeneOntologyMolecularFunctioncalcium ion binding

STAB2 NOL3 DLL4 FAT3 GAS6 DLK1 PKD1L2 ADGRE2 VWCE LDLR STAB1 JAG2 EYS NRXN1 ASPH LRP1 SCUBE3 LRP2 LTBP3 ADGRE1 LTBP4 NOTCH1 NOTCH2 NOTCH3 PADI3

2.13e-0974916325GO:0005509
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

STAB2 LDLR STAB1 LRP1 LRP2 SORL1

1.32e-08211636GO:0030228
GeneOntologyMolecularFunctionNotch binding

DLL4 JAG2 ATRNL1 ADAM17 NOTCH1

2.38e-06271635GO:0005112
GeneOntologyMolecularFunctionneuroligin family protein binding

NRXN3 NRXN1 NRXN2

5.28e-0651633GO:0097109
GeneOntologyMolecularFunctionlow-density lipoprotein particle binding

STAB2 LDLR STAB1 SORL1

1.20e-05181634GO:0030169
GeneOntologyMolecularFunctioncargo receptor activity

STAB2 LDLR STAB1 LRP1 LRP2 SORL1

6.93e-05851636GO:0038024
GeneOntologyMolecularFunctionhistone H3K36 methyltransferase activity

NSD2 NSD1 SETD2

1.44e-04131633GO:0046975
GeneOntologyMolecularFunctionlipoprotein particle binding

STAB2 LDLR STAB1 SORL1

1.84e-04351634GO:0071813
GeneOntologyMolecularFunctionprotein-lipid complex binding

STAB2 LDLR STAB1 SORL1

1.84e-04351634GO:0071814
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

NPC1 ERBB4 HTR2C GRM2 ADGRE2 CR1 LEPR GFRA1 GFRA3 IGF1R NRXN3 CSF3R NRXN1 NRXN2 OR52H1 UNC5C LRP5 IL17RA ADGRE1 LTBP4 ALK NOTCH1 NOTCH2 SORL1

2.64e-04135316324GO:0004888
GeneOntologyMolecularFunctionhistone H3K36 dimethyltransferase activity

NSD2 NSD1

3.93e-0441632GO:0140954
GeneOntologyMolecularFunctionmetalloendopeptidase activity involved in amyloid precursor protein catabolic process

ADAM19 ADAM17

3.93e-0441632GO:1902945
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

NSD2 NSD1 SETD2 EHMT1

4.50e-04441634GO:0140938
GeneOntologyMolecularFunctionmetalloendopeptidase activity

ADAM19 ADAMTS1 ADAM29 ADAM12 ADAMTS12 ADAM17

4.58e-041201636GO:0004222
GeneOntologyMolecularFunctionglial cell-derived neurotrophic factor receptor activity

GFRA1 GFRA3

6.52e-0451632GO:0016167
GeneOntologyMolecularFunctionhistone H3K36 trimethyltransferase activity

NSD2 SETD2

6.52e-0451632GO:0140955
GeneOntologyMolecularFunctionfour-way junction helicase activity

WRN FANCM

9.72e-0461632GO:0009378
GeneOntologyMolecularFunctioncalcium channel regulator activity

GRM2 NRXN3 NRXN1 NRXN2

9.85e-04541634GO:0005246
GeneOntologyMolecularFunctioncytokine receptor activity

LEPR GFRA1 GFRA3 CSF3R IL17RA

1.20e-03971635GO:0004896
GeneOntologyMolecularFunctionscavenger receptor activity

STAB2 STAB1 LRP1

1.35e-03271633GO:0005044
GeneOntologyMolecularFunctioncytokine binding

LEPR CSF3R SCUBE3 ADAM17 LTBP3 LTBP4

1.85e-031571636GO:0019955
GeneOntologyMolecularFunctionion channel regulator activity

ANK2 GRM2 GPD1L NRXN3 NRXN1 NRXN2

2.17e-031621636GO:0099106
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

NSD2 NSD1 SETD2 EHMT1

2.32e-03681634GO:0016279
GeneOntologyMolecularFunctionimmune receptor activity

CR1 LEPR GFRA1 GFRA3 CSF3R IL17RA

2.37e-031651636GO:0140375
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

NSD2 NSD1 SETD2 EHMT1

2.45e-03691634GO:0016278
GeneOntologyBiologicalProcessaxon guidance

LAMC2 GDNF GFRA3 NRXN3 NRXN1 SEMA5B UNC5C LRP1 LRP2 ADAM17 NOTCH1 NOTCH2 NOTCH3

4.22e-0728516213GO:0007411
GeneOntologyBiologicalProcessneuron projection guidance

LAMC2 GDNF GFRA3 NRXN3 NRXN1 SEMA5B UNC5C LRP1 LRP2 ADAM17 NOTCH1 NOTCH2 NOTCH3

4.39e-0728616213GO:0097485
GeneOntologyBiologicalProcesscardiac atrium development

ANK2 DLL4 NSD2 IGF1R NOTCH1 NOTCH2

8.88e-07421626GO:0003230
GeneOntologyBiologicalProcesstissue remodeling

NOL3 DLL4 DLK1 LEPR PLEKHM1 WNT16 CST5 LRP1 LRP5 LTBP3 TNFAIP3 NOTCH2

1.14e-0626216212GO:0048771
GeneOntologyBiologicalProcessblood vessel morphogenesis

STAB2 THSD7A ADAMTS1 DLL4 CAMP ADAM12 LDLR LEPR STAB1 SETD2 NRXN3 NRXN1 LRP1 LRP2 LRP5 TNFAIP3 RECK NOTCH1 NOTCH2 NOTCH3 SPINK5

1.80e-0681716221GO:0048514
GeneOntologyBiologicalProcesscirculatory system development

SP2 ERBB4 STAB2 ADAM19 THSD7A ANK2 ADAMTS1 DLL4 NSD2 CAMP ADAM12 LDLR LEPR STAB1 SETD2 IGF1R NRXN3 NRXN1 WNT16 LRP1 LRP2 LRP5 AKAP13 TNFAIP3 RECK NOTCH1 NOTCH2 NOTCH3 SPINK5

2.51e-06144216229GO:0072359
GeneOntologyBiologicalProcessanatomical structure formation involved in morphogenesis

STAB2 SPEM3 THSD7A ANK2 ADAMTS1 DLL4 FAT3 CAMP ADAM12 GDNF LEPR STAB1 SETD2 NRXN3 CSF3R NRXN1 FIG4 WNT16 ERVK-8 LRP2 AKAP13 ADAM17 TNFAIP3 CCNB1IP1 RECK NOTCH1 NOTCH2 NOTCH3 SPINK5

4.34e-06148316229GO:0048646
GeneOntologyBiologicalProcesspositive regulation of lysosomal protein catabolic process

LDLR LRP1 LRP2

4.70e-0651623GO:1905167
GeneOntologyBiologicalProcesschemoattraction of axon

GDNF LRP1 LRP2

4.70e-0651623GO:0061642
GeneOntologyBiologicalProcessbone remodeling

DLK1 LEPR PLEKHM1 WNT16 LRP5 LTBP3 TNFAIP3 NOTCH2

7.40e-061271628GO:0046849
GeneOntologyBiologicalProcessblood vessel development

STAB2 THSD7A ADAMTS1 DLL4 CAMP ADAM12 LDLR LEPR STAB1 SETD2 NRXN3 NRXN1 LRP1 LRP2 LRP5 TNFAIP3 RECK NOTCH1 NOTCH2 NOTCH3 SPINK5

1.30e-0592916221GO:0001568
GeneOntologyBiologicalProcesspositive regulation of protein catabolic process in the vacuole

LDLR LRP1 LRP2

1.63e-0571623GO:1904352
GeneOntologyBiologicalProcesstube morphogenesis

STAB2 THSD7A ADAMTS1 DLL4 CAMP ADAM12 GDNF LDLR LEPR STAB1 ADAMTS12 SETD2 NRXN3 NRXN1 LRP1 LRP2 LRP5 TNFAIP3 RECK NOTCH1 NOTCH2 NOTCH3 SPINK5

2.43e-05112516223GO:0035239
GeneOntologyBiologicalProcessvasculature development

STAB2 THSD7A ADAMTS1 DLL4 CAMP ADAM12 LDLR LEPR STAB1 SETD2 NRXN3 NRXN1 LRP1 LRP2 LRP5 TNFAIP3 RECK NOTCH1 NOTCH2 NOTCH3 SPINK5

2.43e-0596916221GO:0001944
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

WASL FAT3 LAMC2 BCL11A TECTA GDNF GFRA3 IGF1R NRXN3 NRXN1 SEMA5B UNC5C LRP1 LRP2 ADAM17 NOTCH1 NOTCH2 NOTCH3

2.51e-0574816218GO:0048667
GeneOntologyBiologicalProcessadult behavior

NPC1 HTR2C SLC10A4 GRM2 GDNF NRXN3 NRXN1 NRXN2 ALK

3.35e-052031629GO:0030534
GeneOntologyBiologicalProcessaxonogenesis

LAMC2 BCL11A GDNF GFRA3 IGF1R NRXN3 NRXN1 SEMA5B UNC5C LRP1 LRP2 ADAM17 NOTCH1 NOTCH2 NOTCH3

4.18e-0556616215GO:0007409
GeneOntologyBiologicalProcessNotch signaling pathway

DLL4 DTX3 DLK1 JAG2 ADAM17 RECK NOTCH1 NOTCH2 NOTCH3

4.36e-052101629GO:0007219
GeneOntologyBiologicalProcessangiogenesis

STAB2 THSD7A ADAMTS1 DLL4 CAMP ADAM12 LEPR STAB1 SETD2 NRXN3 NRXN1 TNFAIP3 RECK NOTCH1 NOTCH2 NOTCH3 SPINK5

4.38e-0570816217GO:0001525
GeneOntologyBiologicalProcesscardiac chamber development

ANK2 ADAMTS1 DLL4 NSD2 IGF1R LRP1 LRP2 NOTCH1 NOTCH2

4.70e-052121629GO:0003205
GeneOntologyBiologicalProcessneuron projection development

WASL ADAMTS1 FAT3 LAMC2 BCL11A ITGA1 TECTA GDNF GFRA1 GFRA3 IGF1R NRXN3 NRXN1 TENM3 SEMA5B FIG4 UNC5C LRP1 LRP2 ADAM17 ALK NOTCH1 NOTCH2 NOTCH3

6.73e-05128516224GO:0031175
GeneOntologyBiologicalProcessregulation of tissue remodeling

DLK1 LEPR PLEKHM1 CST5 LRP1 LTBP3 TNFAIP3

6.91e-051281627GO:0034103
GeneOntologyBiologicalProcessartery morphogenesis

DLL4 LDLR LRP1 LRP2 NOTCH1 NOTCH3

8.74e-05921626GO:0048844
GeneOntologyBiologicalProcesstube development

STAB2 THSD7A ADAMTS1 DLL4 CAMP ADAM12 GDNF LDLR LEPR STAB1 ADAMTS12 SETD2 GJB1 NRXN3 NRXN1 LRP1 LRP2 LRP5 LTBP3 TNFAIP3 RECK NOTCH1 NOTCH2 NOTCH3 SPINK5

9.80e-05140216225GO:0035295
GeneOntologyBiologicalProcessregulation of lysosomal protein catabolic process

LDLR LRP1 LRP2

9.93e-05121623GO:1905165
GeneOntologyBiologicalProcessanimal organ morphogenesis

ERBB4 ADAMTS1 DLL4 NSD2 FAT3 LAMC2 TECTA GDNF RING1 JAG2 SETD2 IGF1R CSF3R TENM3 WNT16 CST5 LRP2 LRP5 LTBP3 PAX4 TNFAIP3 NOTCH1 NOTCH2

1.51e-04126916223GO:0009887
GeneOntologyBiologicalProcesscardiac atrium morphogenesis

DLL4 NSD2 NOTCH1 NOTCH2

1.59e-04351624GO:0003209
GeneOntologyBiologicalProcesspositive regulation of neuron projection development

ADAMTS1 BCL11A IGF1R NRXN1 TENM3 FIG4 LRP1 ADAM17 ALK

1.60e-042491629GO:0010976
GeneOntologyBiologicalProcessregulation of protein catabolic process in the vacuole

LDLR LRP1 LRP2

1.62e-04141623GO:1904350
GeneOntologyBiologicalProcessaxon development

LAMC2 BCL11A GDNF GFRA3 IGF1R NRXN3 NRXN1 SEMA5B UNC5C LRP1 LRP2 ADAM17 NOTCH1 NOTCH2 NOTCH3

1.69e-0464216215GO:0061564
GeneOntologyBiologicalProcesscellular response to tumor cell

NOTCH1 NOTCH2

1.83e-0431622GO:0071228
GeneOntologyBiologicalProcessneuron projection morphogenesis

WASL LAMC2 BCL11A ITGA1 GDNF GFRA3 IGF1R NRXN3 NRXN1 SEMA5B UNC5C LRP1 LRP2 ADAM17 NOTCH1 NOTCH2 NOTCH3

1.98e-0480216217GO:0048812
GeneOntologyBiologicalProcessglial cell-derived neurotrophic factor receptor signaling pathway

GDNF GFRA1 GFRA3

2.02e-04151623GO:0035860
GeneOntologyBiologicalProcesschemotaxis

WASL GAS6 ITGA1 ADGRE2 GDNF CSF3R SEMA5B UNC5C LRP1 LRP2 ADAM17 IL17RA NOTCH1

2.30e-0451716213GO:0006935
GeneOntologyBiologicalProcesstaxis

WASL GAS6 ITGA1 ADGRE2 GDNF CSF3R SEMA5B UNC5C LRP1 LRP2 ADAM17 IL17RA NOTCH1

2.39e-0451916213GO:0042330
GeneOntologyBiologicalProcessneuron cell-cell adhesion

NRXN3 NRXN1 NRXN2

2.47e-04161623GO:0007158
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

WASL LAMC2 BCL11A ITGA1 GDNF GFRA3 IGF1R NRXN3 NRXN1 SEMA5B UNC5C LRP1 LRP2 ADAM17 NOTCH1 NOTCH2 NOTCH3

2.53e-0481916217GO:0120039
GeneOntologyBiologicalProcessnegative regulation of peptidase activity

NOL3 GAS6 CR1 CST5 LRP1 WFDC12 RECK SPINK5

2.61e-042101628GO:0010466
GeneOntologyBiologicalProcessamyloid-beta clearance

LDLR IGF1R LRP1 LRP2

2.69e-04401624GO:0097242
GeneOntologyBiologicalProcesscell projection morphogenesis

WASL LAMC2 BCL11A ITGA1 GDNF GFRA3 IGF1R NRXN3 NRXN1 SEMA5B UNC5C LRP1 LRP2 ADAM17 NOTCH1 NOTCH2 NOTCH3

2.79e-0482616217GO:0048858
GeneOntologyBiologicalProcessnegative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

ZNRF4 TNFAIP3

3.64e-0441622GO:0070433
GeneOntologyBiologicalProcessnegative regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

ZNRF4 TNFAIP3

3.64e-0441622GO:0070425
GeneOntologyBiologicalProcessneuroligin clustering involved in postsynaptic membrane assembly

NRXN1 NRXN2

3.64e-0441622GO:0097118
GeneOntologyBiologicalProcessnegative regulation of catalytic activity

NOL3 GAS6 GRM2 CR1 LEPR CST5 LRP1 LRP5 TNFAIP3 SMCR8 WFDC12 RECK NOTCH1 SPINK5

3.64e-0461516214GO:0043086
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

ERBB4 DLL4 GAS6 GDNF GFRA1 ADAMTS12 IGF1R NRXN1 LRP1 SCUBE3 LRP2 ADAM17 LTBP3 LTBP4 NOTCH1 NOTCH2 SORL1

3.88e-0485016217GO:0071363
GeneOntologyBiologicalProcesscamera-type eye morphogenesis

FAT3 RING1 TENM3 WNT16 LRP5 NOTCH1 NOTCH2

4.13e-041711627GO:0048593
GeneOntologyBiologicalProcesspositive regulation of neural precursor cell proliferation

DLL4 DCT LRP2 NOTCH1 NOTCH2

4.20e-04801625GO:2000179
GeneOntologyBiologicalProcessregulation of bone remodeling

DLK1 LEPR PLEKHM1 LTBP3 TNFAIP3

4.20e-04801625GO:0046850
GeneOntologyBiologicalProcessnegative regulation of cellular component organization

WASL NOL3 EML4 FAT3 BCL11A PRRT2 LDLR NRXN1 DNAJA4 CST5 LRP1 TNKS ADAM17 CKAP2 SMCR8 NOTCH1 SORL1

4.67e-0486416217GO:0051129
GeneOntologyBiologicalProcessneuron development

WASL ADAMTS1 FAT3 LAMC2 BCL11A ITGA1 TECTA GDNF GFRA1 GFRA3 IGF1R NRXN3 NRXN1 TENM3 SEMA5B FIG4 UNC5C LRP1 LRP2 ADAM17 ALK NOTCH1 NOTCH2 NOTCH3

4.70e-04146316224GO:0048666
GeneOntologyBiologicalProcessembryonic morphogenesis

DLL4 MBNL1 NSD1 TECTA GDNF JAG2 SETD2 TRIM28 WNT16 LRP2 LRP5 TNFAIP3 RECK NOTCH1 NOTCH2

5.14e-0471316215GO:0048598
GeneOntologyBiologicalProcessresponse to growth factor

ERBB4 DLL4 GAS6 GDNF GFRA1 ADAMTS12 IGF1R NRXN1 LRP1 SCUBE3 LRP2 ADAM17 LTBP3 LTBP4 NOTCH1 NOTCH2 SORL1

5.97e-0488316217GO:0070848
GeneOntologyBiologicalProcessnegative regulation of hydrolase activity

NOL3 GAS6 CR1 LEPR CST5 LRP1 WFDC12 RECK SPINK5

5.98e-042981629GO:0051346
GeneOntologyBiologicalProcessgephyrin clustering involved in postsynaptic density assembly

NRXN1 NRXN2

6.04e-0451622GO:0097116
GeneOntologyBiologicalProcesspositive regulation of ERK1 and ERK2 cascade

ERBB4 HTR2C GAS6 NRXN1 LRP1 ADAM17 NOTCH1 NOTCH2

6.35e-042401628GO:0070374
GeneOntologyBiologicalProcessartery development

DLL4 LDLR LRP1 LRP2 NOTCH1 NOTCH3

6.45e-041331626GO:0060840
GeneOntologyBiologicalProcesssignal release

HTR2C PRRT2 GRM2 GDNF LEPR NRXN3 NRXN1 NRXN2 SYTL4 LRP1 SYP LRP5 ADAM17 LTBP4

6.59e-0465316214GO:0023061
GeneOntologyBiologicalProcesscardiac septum development

ANK2 NSD2 LRP1 LRP2 NOTCH1 NOTCH2

6.71e-041341626GO:0003279
GeneOntologyBiologicalProcesssecretion by cell

HTR2C PRRT2 GRM2 ADGRE2 GDNF LEPR NRXN3 MALRD1 NRXN1 NRXN2 SYTL4 LRP1 SYP LRP5 ADAM17 OLFM2 SMCR8 LTBP4 NOTCH1

7.07e-04106416219GO:0032940
GeneOntologyBiologicalProcesspositive regulation of Notch signaling pathway

DLL4 JAG2 RECK NOTCH1

7.96e-04531624GO:0045747
GeneOntologyBiologicalProcesspositive regulation of protein localization

ERBB4 GAS6 LEPR GPD1L MALRD1 NRXN1 SYTL4 TRIM28 ASPH LRP1 LRP2 LRP5 SORL1

8.12e-0459116213GO:1903829
GeneOntologyBiologicalProcessendocytosis

NPC1 WASL STAB2 ANK2 GAS6 LDLR LEPR STAB1 MTMR6 ARFGAP3 LRP1 LRP2 LRP3 SYP LRP5 SORL1

8.24e-0482716216GO:0006897
GeneOntologyBiologicalProcessvocalization behavior

NRXN3 NRXN1 NRXN2

8.53e-04241623GO:0071625
GeneOntologyBiologicalProcesslysosomal protein catabolic process

LDLR LRP1 LRP2

8.53e-04241623GO:1905146
GeneOntologyBiologicalProcesstranscytosis

IGF1R LRP1 LRP2

8.53e-04241623GO:0045056
GeneOntologyBiologicalProcessmembrane organization

NPC1 WASL SPIRE2 ANK2 NOL3 GAS6 ZNF205 PRRT2 CR1 GDNF PLEKHM1 NRXN1 NRXN2 SYTL4 ARFGAP3 SYP LRP5

8.75e-0491416217GO:0061024
GeneOntologyBiologicalProcessinner ear receptor cell fate commitment

JAG2 NOTCH1

9.01e-0461622GO:0060120
GeneOntologyBiologicalProcessglomerulus vasculature morphogenesis

NOTCH2 NOTCH3

9.01e-0461622GO:0072103
GeneOntologyBiologicalProcessglomerular capillary formation

NOTCH2 NOTCH3

9.01e-0461622GO:0072104
GeneOntologyBiologicalProcessauditory receptor cell fate commitment

JAG2 NOTCH1

9.01e-0461622GO:0009912
GeneOntologyCellularComponentreceptor complex

TRAF1 ERBB4 HTR2C ITGA1 CR1 GDNF LDLR LEPR GFRA1 GFRA3 AHRR IGF1R CSF3R LRP1 LRP2 LRP5 OLFM2 ALK NOTCH1 NOTCH2 NOTCH3

7.55e-0958116621GO:0043235
GeneOntologyCellularComponentexternal side of plasma membrane

STAB2 ADAM19 HTR2C ADAM29 DLK1 ITGA1 ADGRE2 CR1 LDLR LEPR GFRA1 GFRA3 CSF3R LRP1 LRP2 ADGRE1

4.06e-0651916616GO:0009897
GeneOntologyCellularComponentcell surface

STAB2 ADAM19 HTR2C ADAM29 DLK1 ITGA1 ADGRE2 CR1 LDLR LEPR GFRA1 GFRA3 CSF3R NRXN1 UNC5C LRP1 SCUBE3 LRP2 ADAM17 ADGRE1 NOTCH1 NOTCH2 NOTCH3 SORL1

7.78e-06111116624GO:0009986
GeneOntologyCellularComponentside of membrane

TRAF1 STAB2 ADAM19 HTR2C ANK2 ADAM29 DLK1 ITGA1 TECTA ADGRE2 CR1 LDLR LEPR GFRA1 GFRA3 CSF3R LRP1 LRP2 ADGRE1 RECK

2.15e-0587516620GO:0098552
DomainEGF-like_dom

STAB2 ADAM19 DLL4 FAT3 GAS6 LAMC2 ADAM29 DLK1 TECTA ADGRE2 VWCE ADAM12 LDLR STAB1 JAG2 EYS NRXN3 FCGBP MALRD1 NRXN1 TENM3 NRXN2 ATRNL1 LRP1 SCUBE3 LRP2 LRP5 LTBP3 C7 ADGRE1 LTBP4 NOTCH1 NOTCH2 NOTCH3 SORL1

9.27e-3324915935IPR000742
DomainEGF-like_CS

STAB2 ADAM19 DLL4 FAT3 GAS6 LAMC2 ADAM29 DLK1 ZNRF4 ADGRE2 VWCE ADAM12 LDLR STAB1 JAG2 EYS NRXN3 MALRD1 NRXN1 TENM3 NRXN2 ATRNL1 LRP1 SCUBE3 LRP2 LRP5 ADAM17 LTBP3 C7 ADGRE1 LTBP4 NOTCH1 NOTCH2 NOTCH3 SORL1

5.02e-3226115935IPR013032
DomainEGF_3

STAB2 ADAM19 DLL4 FAT3 GAS6 ADAM29 DLK1 ADGRE2 VWCE ADAM12 LDLR STAB1 JAG2 EYS NRXN3 MALRD1 NRXN1 TENM3 NRXN2 ATRNL1 LRP1 SCUBE3 LRP2 LRP5 LTBP3 C7 ADGRE1 LTBP4 NOTCH1 NOTCH2 NOTCH3 SORL1

1.68e-2923515932PS50026
DomainEGF_2

STAB2 ADAM19 DLL4 FAT3 GAS6 LAMC2 ADAM29 DLK1 ADGRE2 VWCE ADAM12 LDLR STAB1 JAG2 EYS NRXN3 MALRD1 NRXN1 TENM3 NRXN2 ATRNL1 LRP1 SCUBE3 LRP2 LRP5 LTBP3 C7 ADGRE1 LTBP4 NOTCH1 NOTCH2 NOTCH3 SORL1

4.09e-2926515933PS01186
DomainEGF_1

STAB2 ADAM19 DLL4 FAT3 GAS6 LAMC2 ADAM29 DLK1 ADGRE2 VWCE ADAM12 LDLR STAB1 JAG2 EYS NRXN3 MALRD1 NRXN1 TENM3 NRXN2 ATRNL1 LRP1 SCUBE3 LRP2 LRP5 LTBP3 C7 ADGRE1 LTBP4 NOTCH1 NOTCH2 NOTCH3

2.41e-2825515932PS00022
DomainEGF

STAB2 DLL4 FAT3 GAS6 LAMC2 DLK1 TECTA ADGRE2 VWCE LDLR STAB1 JAG2 EYS NRXN3 FCGBP MALRD1 NRXN1 TENM3 NRXN2 ATRNL1 LRP1 SCUBE3 LRP2 LRP5 LTBP3 ADGRE1 LTBP4 NOTCH1 NOTCH2 NOTCH3 SORL1

3.79e-2823515931SM00181
DomainASX_HYDROXYL

DLL4 FAT3 GAS6 DLK1 ADGRE2 VWCE LDLR JAG2 EYS NRXN3 NRXN1 LRP1 SCUBE3 LRP2 LTBP3 ADGRE1 LTBP4 NOTCH1 NOTCH2 NOTCH3

3.52e-2210015920PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

DLL4 FAT3 GAS6 DLK1 ADGRE2 VWCE LDLR JAG2 EYS NRXN3 NRXN1 LRP1 SCUBE3 LRP2 LTBP3 ADGRE1 LTBP4 NOTCH1 NOTCH2 NOTCH3

1.22e-2110615920IPR000152
DomainEGF-like_Ca-bd_dom

STAB2 DLL4 FAT3 GAS6 DLK1 ADGRE2 VWCE LDLR STAB1 JAG2 EYS LRP1 SCUBE3 LRP2 LRP5 LTBP3 ADGRE1 LTBP4 NOTCH1 NOTCH2 NOTCH3

1.24e-2112415921IPR001881
DomainEGF_CA

STAB2 DLL4 FAT3 GAS6 DLK1 ADGRE2 VWCE LDLR STAB1 JAG2 EYS LRP1 SCUBE3 LRP2 LTBP3 ADGRE1 LTBP4 NOTCH1 NOTCH2 NOTCH3

2.37e-2012215920SM00179
DomainGrowth_fac_rcpt_

ERBB4 STAB2 DLL4 GAS6 LAMC2 ADGRE2 VWCE LDLR STAB1 JAG2 EYS IGF1R LRP1 SCUBE3 LRP2 LTBP3 ADGRE1 LTBP4 NOTCH1 NOTCH2 NOTCH3

1.80e-1915615921IPR009030
DomainEGF

STAB2 DLL4 GAS6 DLK1 TECTA STAB1 JAG2 EYS NRXN3 MALRD1 NRXN1 NRXN2 LRP1 SCUBE3 LRP2 LRP5 NOTCH1 NOTCH2 NOTCH3

1.14e-1812615919PF00008
DomainEGF_CA

FAT3 GAS6 ADGRE2 VWCE LDLR JAG2 EYS LRP1 SCUBE3 LRP2 LRP5 LTBP3 ADGRE1 LTBP4 NOTCH1 NOTCH2 NOTCH3

8.21e-189915917PS01187
DomainEGF_Ca-bd_CS

FAT3 GAS6 ADGRE2 VWCE LDLR JAG2 EYS LRP1 SCUBE3 LRP2 LTBP3 ADGRE1 LTBP4 NOTCH1 NOTCH2 NOTCH3

1.55e-169715916IPR018097
DomainEGF_CA

FAT3 GAS6 ADGRE2 VWCE LDLR JAG2 LRP1 SCUBE3 LRP2 LTBP3 ADGRE1 LTBP4 NOTCH1 NOTCH2 NOTCH3

5.92e-168615915PF07645
DomainEGF_extracell

STAB2 ADAM19 DLL4 DLK1 ADAM12 STAB1 JAG2 TENM3 ATRNL1 LRP2 NOTCH1 NOTCH3

9.37e-146015912IPR013111
DomainEGF_2

STAB2 ADAM19 DLL4 DLK1 ADAM12 STAB1 JAG2 TENM3 ATRNL1 LRP2 NOTCH1 NOTCH3

9.37e-146015912PF07974
Domain-

LDLR MALRD1 LRP1 LRP2 LRP3 LRP5 C7 TMPRSS7 ALK SORL1

4.71e-1246159104.10.400.10
DomainLDLRA_1

LDLR MALRD1 LRP1 LRP2 LRP3 LRP5 C7 TMPRSS7 ALK SORL1

7.45e-124815910PS01209
DomainLDrepeatLR_classA_rpt

LDLR MALRD1 LRP1 LRP2 LRP3 LRP5 C7 TMPRSS7 ALK SORL1

9.29e-124915910IPR002172
DomainLDLa

LDLR MALRD1 LRP1 LRP2 LRP3 LRP5 C7 TMPRSS7 ALK SORL1

9.29e-124915910SM00192
DomainLDLRA_2

LDLR MALRD1 LRP1 LRP2 LRP3 LRP5 C7 TMPRSS7 ALK SORL1

9.29e-124915910PS50068
DomainLDLR_class-A_CS

LDLR MALRD1 LRP1 LRP2 LRP3 LRP5 C7 TMPRSS7 SORL1

4.08e-11401599IPR023415
DomainLdl_recept_a

LDLR MALRD1 LRP1 LRP2 LRP3 LRP5 C7 TMPRSS7 SORL1

1.28e-10451599PF00057
DomainhEGF

GAS6 JAG2 EYS LTBP3 NOTCH1 NOTCH2 NOTCH3

2.89e-09281597PF12661
DomaincEGF

GAS6 LRP1 SCUBE3 LRP2 LTBP3 ADGRE1

6.93e-08261596PF12662
DomaincEGF

GAS6 LRP1 SCUBE3 LRP2 LTBP3 ADGRE1

6.93e-08261596IPR026823
DomainLdl_recept_b

LDLR LRP1 LRP2 LRP5 SORL1

7.90e-08141595PF00058
DomainLDLRB

LDLR LRP1 LRP2 LRP5 SORL1

7.90e-08141595PS51120
DomainLY

LDLR LRP1 LRP2 LRP5 SORL1

1.18e-07151595SM00135
DomainLDLR_classB_rpt

LDLR LRP1 LRP2 LRP5 SORL1

1.18e-07151595IPR000033
DomainVWC_out

TECTA VWCE JAG2 FCGBP MUC5AC

4.43e-07191595SM00215
DomainDUF3454

NOTCH1 NOTCH2 NOTCH3

6.05e-0731593PF11936
DomainDUF3454_notch

NOTCH1 NOTCH2 NOTCH3

6.05e-0731593IPR024600
DomainDUF3454

NOTCH1 NOTCH2 NOTCH3

6.05e-0731593SM01334
DomainLAM_G_DOMAIN

FAT3 GAS6 EYS NRXN3 NRXN1 NRXN2

7.63e-07381596PS50025
DomainPep_M12B_propep

ADAM19 ADAMTS1 ADAM29 ADAM12 ADAMTS12 ADAM17

8.96e-07391596PF01562
DomainPeptidase_M12B_N

ADAM19 ADAMTS1 ADAM29 ADAM12 ADAMTS12 ADAM17

8.96e-07391596IPR002870
Domain-

LDLR TENM3 LRP1 LRP2 LRP5 SORL1

8.96e-073915962.120.10.30
DomainDISINTEGRIN_1

ADAM19 ADAMTS1 ADAM29 ADAM12 ADAMTS12 ADAM17

1.05e-06401596PS00427
DomainReprolysin

ADAM19 ADAMTS1 ADAM29 ADAM12 ADAMTS12 ADAM17

1.05e-06401596PF01421
DomainLaminin_G_2

FAT3 GAS6 EYS NRXN3 NRXN1 NRXN2

1.05e-06401596PF02210
DomainADAM_MEPRO

ADAM19 ADAMTS1 ADAM29 ADAM12 ADAMTS12 ADAM17

1.05e-06401596PS50215
DomainDISINTEGRIN_2

ADAM19 ADAMTS1 ADAM29 ADAM12 ADAMTS12 ADAM17

1.05e-06401596PS50214
DomainPeptidase_M12B

ADAM19 ADAMTS1 ADAM29 ADAM12 ADAMTS12 ADAM17

1.05e-06401596IPR001590
DomainDisintegrin_dom

ADAM19 ADAMTS1 ADAM29 ADAM12 ADAMTS12 ADAM17

1.22e-06411596IPR001762
DomainLamG

FAT3 GAS6 EYS NRXN3 NRXN1 NRXN2

1.87e-06441596SM00282
DomainNotch

NOTCH1 NOTCH2 NOTCH3

2.41e-0641593IPR008297
DomainNODP

NOTCH1 NOTCH2 NOTCH3

2.41e-0641593PF07684
DomainNotch_NODP_dom

NOTCH1 NOTCH2 NOTCH3

2.41e-0641593IPR011656
DomainNotch_NOD_dom

NOTCH1 NOTCH2 NOTCH3

2.41e-0641593IPR010660
DomainNOD

NOTCH1 NOTCH2 NOTCH3

2.41e-0641593PF06816
DomainNOD

NOTCH1 NOTCH2 NOTCH3

2.41e-0641593SM01338
DomainNODP

NOTCH1 NOTCH2 NOTCH3

2.41e-0641593SM01339
Domain6-blade_b-propeller_TolB-like

LDLR TENM3 LRP1 LRP2 LRP5 SORL1

2.45e-06461596IPR011042
DomainTIL_dom

TECTA FCGBP LRP2 MUC5AC

4.74e-06141594IPR002919
DomainAWS

NSD2 NSD1 SETD2

5.98e-0651593SM00570
DomainAWS

NSD2 NSD1 SETD2

5.98e-0651593PS51215
DomainAWS_dom

NSD2 NSD1 SETD2

5.98e-0651593IPR006560
DomainLNR

NOTCH1 NOTCH2 NOTCH3

5.98e-0651593PS50258
DomainLaminin_G

FAT3 GAS6 EYS NRXN3 NRXN1 NRXN2

9.72e-06581596IPR001791
DomainTSP_1

THSD7A ADAMTS1 ADAMTS12 SEMA5B UNC5C C7

1.58e-05631596PF00090
DomainVWC

TECTA VWCE JAG2 FCGBP MUC5AC

1.68e-05381595SM00214
DomainTSP1

THSD7A ADAMTS1 ADAMTS12 SEMA5B UNC5C C7

1.89e-05651596SM00209
DomainTSP1_rpt

THSD7A ADAMTS1 ADAMTS12 SEMA5B UNC5C C7

1.89e-05651596IPR000884
DomainTSP1

THSD7A ADAMTS1 ADAMTS12 SEMA5B UNC5C C7

1.89e-05651596PS50092
DomainNotch_dom

NOTCH1 NOTCH2 NOTCH3

2.07e-0571593IPR000800
DomainSyndecan

NRXN3 NRXN1 NRXN2

2.07e-0571593PF01034
DomainNotch

NOTCH1 NOTCH2 NOTCH3

2.07e-0571593PF00066
DomainSyndecan/Neurexin_dom

NRXN3 NRXN1 NRXN2

2.07e-0571593IPR027789
DomainNL

NOTCH1 NOTCH2 NOTCH3

2.07e-0571593SM00004
Domain-

ADAM19 ADAM29 ADAM12 ADAM17

2.20e-052015944.10.70.10
DomainDisintegrin

ADAM19 ADAM29 ADAM12 ADAM17

2.70e-05211594PF00200
DomainDISIN

ADAM19 ADAM29 ADAM12 ADAM17

2.70e-05211594SM00050
DomainVWF_dom

TECTA VWCE JAG2 FCGBP MUC5AC

2.77e-05421595IPR001007
Domain-

ADAM19 ADAMTS1 ADAM29 ADAM12 ADAMTS12 ADAM17

6.64e-058115963.40.390.10
DomainMetalloPept_cat_dom

ADAM19 ADAMTS1 ADAM29 ADAM12 ADAMTS12 ADAM17

6.64e-05811596IPR024079
DomainADAM_Cys-rich

ADAM19 ADAMTS1 ADAM29 ADAM12

7.62e-05271594IPR006586
DomainACR

ADAM19 ADAMTS1 ADAM29 ADAM12

7.62e-05271594SM00608
DomainEGF_LAM_2

STAB2 LAMC2 STAB1 ATRNL1

1.17e-04301594PS50027
DomainEGF_LAM_1

STAB2 LAMC2 STAB1 ATRNL1

1.17e-04301594PS01248
DomainEGF_dom

STAB2 STAB1 SCUBE3

1.26e-04121593IPR024731
DomainC8

TECTA FCGBP MUC5AC

1.26e-04121593PF08742
DomainEGF_3

STAB2 STAB1 SCUBE3

1.26e-04121593PF12947
DomainTIL

TECTA FCGBP MUC5AC

1.26e-04121593PF01826
Domain-

FAT3 GAS6 EYS NRXN3 NRXN1 NRXN2

1.61e-049515962.60.120.200
DomainUnchr_dom_Cys-rich

TECTA FCGBP MUC5AC

1.63e-04131593IPR014853
DomainC8

TECTA FCGBP MUC5AC

1.63e-04131593SM00832
DomainZINC_PROTEASE

ADAM19 ADAMTS1 ADAM29 ADAM12 ADAMTS12 ADAM17

1.91e-04981596PS00142
DomainNeurexin-like

NRXN3 NRXN1 NRXN2

2.06e-04141593IPR003585
Domain4.1m

NRXN3 NRXN1 NRXN2

2.06e-04141593SM00294
DomainTILa_dom

TECTA FCGBP

2.15e-0431592IPR025615
DomainTILa

TECTA FCGBP

2.15e-0431592PF12714
DomainEGF_Lam

STAB2 LAMC2 STAB1 ATRNL1

2.16e-04351594SM00180
DomainVWFC_2

TECTA VWCE JAG2 MUC5AC

2.98e-04381594PS50184
DomainLaminin_EGF

STAB2 LAMC2 STAB1 ATRNL1

2.98e-04381594IPR002049
DomainPost-SET_dom

NSD2 NSD1 SETD2

3.13e-04161593IPR003616
DomainPostSET

NSD2 NSD1 SETD2

3.13e-04161593SM00508
DomainVWF_type-D

TECTA FCGBP MUC5AC

3.13e-04161593IPR001846
DomainVWFD

TECTA FCGBP MUC5AC

3.13e-04161593PS51233
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

5.01e-08131205M47423
PathwayWP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING

DLL4 DLK1 JAG2 NOTCH1 NOTCH2 NOTCH3

8.58e-08271206M39545
PathwayWP_NOTCH_SIGNALING_WP268

DLL4 DTX3 JAG2 ADAM17 NOTCH1 NOTCH2 NOTCH3

9.43e-08451207M39571
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

THSD7A ADAMTS1 ADAMTS12 SEMA5B MUC5AC NOTCH1 NOTCH2 NOTCH3

1.05e-07681208M27303
PathwayWP_NOTCH_SIGNALING_PATHWAY

DLL4 DTX3 JAG2 ADAM17 NOTCH1 NOTCH2 NOTCH3

1.10e-07461207MM15971
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

DLL4 DTX3 JAG2 ADAM17 NOTCH1 NOTCH2 NOTCH3

1.29e-07471207M7946
PathwayREACTOME_SIGNALING_BY_NOTCH1_T_7_9_NOTCH1_M1580_K2555_TRANSLOCATION_MUTANT

DLL4 JAG2 ADAM17 NOTCH1

1.71e-0771204M27199
PathwayPID_NOTCH_PATHWAY

DLL4 DLK1 ADAM12 JAG2 NOTCH1 NOTCH2 NOTCH3

6.42e-07591207M17
PathwayWP_NOTCH_SIGNALING_WP61

DLL4 RING1 JAG2 ADAM17 NOTCH1 NOTCH2 NOTCH3

8.10e-07611207M39540
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION

ADAM17 NOTCH1 NOTCH2 NOTCH3

1.57e-06111204M47865
PathwayREACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS

DLL4 DLK1 JAG2 ADAM17 NOTCH1

5.85e-06311205M592
PathwayREACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3

NOTCH1 NOTCH2 NOTCH3

5.94e-0651203M27411
PathwayWP_DELTANOTCH_SIGNALING_PATHWAY

DLL4 RING1 JAG2 ADAM17 NOTCH1 NOTCH2 NOTCH3

6.09e-06821207MM15922
PathwayREACTOME_SIGNALING_BY_NOTCH1_HD_DOMAIN_MUTANTS_IN_CANCER

DLL4 JAG2 ADAM17 NOTCH1

6.34e-06151204M27202
PathwayWP_NOTCH1_REGULATION_OF_ENDOTHELIAL_CELL_CALCIFICATION

DLL4 ITGA1 JAG2 NOTCH1

1.09e-05171204M39389
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM

NOTCH1 NOTCH2 NOTCH3

1.18e-0561203M27068
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

THSD7A ADAMTS1 ADAMTS12 SEMA5B MUC5AC NOTCH1 NOTCH2 NOTCH3

2.98e-051431208M27275
PathwayKEGG_DORSO_VENTRAL_AXIS_FORMATION

SPIRE2 NOTCH1 NOTCH2 NOTCH3

4.65e-05241204M11190
PathwayWP_BREAST_CANCER_PATHWAY

DLL4 JAG2 IGF1R WNT16 LRP5 NOTCH1 NOTCH2 NOTCH3

5.05e-051541208M39739
PathwayWP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES

DLL4 JAG2 WNT16 LRP5 NOTCH1 NOTCH2 NOTCH3

6.56e-051181207M39852
PathwayWP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER

DLL4 DLK1 JAG2 WNT16 LRP5 NOTCH1 NOTCH2 NOTCH3

6.92e-051611208M39770
PathwayREACTOME_ALK_MUTANTS_BIND_TKIS

EML4 BCL11A ALK

1.25e-04121203M42522
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380

NOTCH1 NOTCH2 NOTCH3

1.25e-04121203M47532
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381

NOTCH1 NOTCH2 NOTCH3

1.25e-04121203M47533
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382

NOTCH1 NOTCH2 NOTCH3

1.62e-04131203M47534
PathwayWP_NEURAL_CREST_DIFFERENTIATION

DLL4 DCT GJB1 NOTCH1 NOTCH2 NOTCH3

1.76e-04971206MM15926
PathwayWP_NEURAL_CREST_DIFFERENTIATION

DLL4 DCT GJB1 NOTCH1 NOTCH2 NOTCH3

2.20e-041011206M39448
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

ADAM19 ADAMTS1 LAMC2 ITGA1 ADAM12 NRXN1 SCUBE3 ADAM17 LTBP3 LTBP4

2.42e-0430012010M610
PathwayKEGG_MEDICUS_VARIANT_NOTCH_OVEREXPRESSION_TO_NOTCH_SIGNALING_PATHWAY

DLL4 JAG2 NOTCH1

3.11e-04161203M47424
PathwayREACTOME_SIGNALING_BY_NOTCH

DLL4 JAG2 NOTCH1 NOTCH3

3.26e-04391204MM14604
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

THSD7A ADAMTS1 ADAMTS12 SEMA5B

3.26e-04391204M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

THSD7A ADAMTS1 ADAMTS12 SEMA5B

3.26e-04391204MM15165
PathwayWP_CANCER_PATHWAYS

TRAF1 DLL4 EML4 LAMC2 JAG2 IGF1R CSF3R WNT16 LRP5 ALK NOTCH1 NOTCH2 NOTCH3

3.77e-0450712013M48302
PathwayWP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES

NPC1 STAB2 ANK2 LDLR MTMR6 LRP1 LRP2 LRP3 SYP LRP5 SORL1

4.05e-0438112011M48063
PathwayREACTOME_SIGNALING_BY_NOTCH1

DLL4 DLK1 JAG2 ADAM17 NOTCH1

4.14e-04741205M616
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH1 NOTCH2 NOTCH3

4.47e-04181203M614
PathwayKEGG_LYSINE_DEGRADATION

NSD2 NSD1 SETD2 EHMT1

5.21e-04441204M13720
PathwayREACTOME_SIGNALING_BY_NOTCH3

DLL4 JAG2 NOTCH3

5.28e-04191203MM15594
PathwayREACTOME_PKMTS_METHYLATE_HISTONE_LYSINES

NSD2 NSD1 SETD2 EHMT1

6.18e-04461204MM14933
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH1 NOTCH3

7.07e-0451202MM14733
PathwayREACTOME_SIGNALING_BY_NOTCH3

DLL4 JAG2 NOTCH1 NOTCH3

7.87e-04491204M618
PathwayREACTOME_NOTCH2_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

DLL4 JAG2 NOTCH2

8.23e-04221203M27210
PathwayBIOCARTA_NOTCH_PATHWAY

ADAM17 NOTCH1

1.05e-0361202MM1584
PathwayBIOCARTA_NOTCH_PATHWAY

ADAM17 NOTCH1

1.05e-0361202M22074
PathwayREACTOME_NOTCH3_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

DLL4 JAG2 NOTCH3

1.21e-03251203M27879
PathwayREACTOME_DISEASES_OF_METABOLISM

THSD7A ADAMTS1 ADAMTS12 SEMA5B MUC5AC NOTCH1 NOTCH2 NOTCH3

1.33e-032501208M27554
PathwayBIOCARTA_ERBB4_PATHWAY

ERBB4 ADAM17

1.47e-0371202MM1563
PathwayBIOCARTA_ERBB4_PATHWAY

ERBB4 ADAM17

1.47e-0371202M22043
PathwayREACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING

NOTCH1 NOTCH3

1.47e-0371202MM14734
PathwayREACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER

DLL4 JAG2 ADAM17 NOTCH1

1.49e-03581204M29616
PathwayWP_HIPPOCAMPAL_SYNAPTOGENESIS_AND_NEUROGENESIS

NRXN3 NRXN1 NRXN2

1.52e-03271203M45550
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

NOTCH1 NOTCH2 NOTCH3

1.69e-03281203M6177
PathwayKEGG_MEDICUS_REFERENCE_PLASMIN_MEDIATED_ACTIVATION_OF_LATENT_TGF_BETA

LTBP3 LTBP4

1.95e-0381202M47850
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

THSD7A ZNF318 ZNF77 RESF1 NRXN1 ATRNL1 LRP1 LRP2 LTBP3 MUC5AC SPINK5

4.78e-14711681133541421
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

ERBB4 CR1 LDLR LEPR IGF1R LRP1 LRP2 ALK NOTCH1 NOTCH2 NOTCH3

2.62e-121011681123382219
Pubmed

Segmental expression of Notch and Hairy genes in nephrogenesis.

DLL4 DLK1 JAG2 NOTCH1 NOTCH2 NOTCH3

1.38e-1017168615821257
Pubmed

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

3.07e-109168516245338
Pubmed

Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

6.12e-1010168523665443
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

NPC1 SPIRE2 NSD2 GRK6 NSD1 LDLR PLEKHM1 DHX30 JAG2 IGF1R OVOL1 WIZ TRIM28 PPP1R15B EHMT1 LRP3 LRP5 AKAP13 HMGXB3 LTBP3 TNFAIP3 LTBP4 NOTCH1 NOTCH2

8.26e-1011051682435748872
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ERBB4 ADAMTS1 NSD2 FAT3 GAS6 ZNF318 BCL11A CHAMP1 LDLR SETD2 RESF1 WIZ TRIM28 DROSHA LRP1 EHMT1 LRP2 ADAM17 TAF6 LTBP4 GARRE1 ZMYM3 NOTCH2 SORL1

1.00e-0911161682431753913
Pubmed

Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

1.91e-0912168515465494
Pubmed

Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.

LRP1 LRP2 LRP3 SORL1

2.62e-095168419047013
Pubmed

Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4).

DLL4 NOTCH1 NOTCH2 NOTCH3

2.62e-095168423675950
Pubmed

Functional diversity of notch family genes in fetal lung development.

JAG2 NOTCH1 NOTCH2 NOTCH3

2.62e-095168415064243
Pubmed

Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

3.09e-0913168511578869
Pubmed

Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

4.79e-0914168514757642
Pubmed

Notch signaling in stomach epithelial stem cell homeostasis.

DLK1 JAG2 MUC5AC NOTCH1 NOTCH2 NOTCH3

5.03e-0929168621402740
Pubmed

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

7.15e-0915168512971992
Pubmed

Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2.

DLK1 JAG2 NOTCH1 NOTCH2

7.82e-096168410958687
Pubmed

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

1.04e-0816168517273555
Pubmed

Expression of Notch pathway components in fetal and adult mouse small intestine.

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

1.04e-0816168512617809
Pubmed

Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

1.46e-0817168518694942
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

NPC1 ZNF473 MBNL1 NSD1 SHMT1 DIDO1 ZNF318 ADGRE2 LDLR MTMR6 ZSCAN10 RESF1 DNAAF10 ATRNL1 UNC5C LRP2 HMGXB3 ADAM17 TNFAIP3 CKAP2 KIF13A SLC33A1

1.50e-0810841682211544199
Pubmed

Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development.

JAG2 NOTCH1 NOTCH2 NOTCH3

1.82e-087168410383933
Pubmed

Human ligands of the Notch receptor.

JAG2 NOTCH1 NOTCH2 NOTCH3

1.82e-087168410079256
Pubmed

The distribution of Notch receptors and their ligands during articular cartilage development.

JAG2 NOTCH1 NOTCH2 NOTCH3

1.82e-087168412846471
Pubmed

Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis.

JAG2 NOTCH1 NOTCH2 NOTCH3

1.82e-087168416169548
Pubmed

RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

2.02e-0818168515689374
Pubmed

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling.

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

2.02e-0818168518093989
Pubmed

Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium.

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

2.73e-0819168516518823
Pubmed

P4 down-regulates Jagged2 and Notch1 expression during primordial folliculogenesis.

JAG2 NOTCH1 NOTCH2 NOTCH3

3.62e-088168422652674
Pubmed

Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.

JAG2 NOTCH1 NOTCH2 NOTCH3

3.62e-08816849858718
Pubmed

Notch/Delta expression in the developing mouse lung.

JAG2 NOTCH1 NOTCH2 NOTCH3

3.62e-088168411044610
Pubmed

Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.

DLL4 JAG2 MUC5AC NOTCH1 NOTCH2 NOTCH3

4.54e-0841168622675208
Pubmed

Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception.

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

4.74e-0821168528656980
Pubmed

Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme.

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

6.10e-0822168521750033
Pubmed

Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system.

JAG2 NOTCH1 NOTCH2 NOTCH3

6.50e-089168411118901
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

ZNF787 SP2 DTX3 MBNL1 DIDO1 ZNF318 BCL11A ZNF467 CHAMP1 RING1 AHRR OVOL1 TRIM28 HMGXB3 PAX4 ZMYM3 FOXD4

7.09e-087091681722988430
Pubmed

Aberrant epidermal differentiation and disrupted ΔNp63/Notch regulatory axis in Ets1 transgenic mice.

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

7.77e-0823168524337118
Pubmed

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

7.77e-0823168514701881
Pubmed

Dynamics of Notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle.

DLL4 NOTCH1 NOTCH2 NOTCH3

1.08e-0710168424015274
Pubmed

Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic Ca2+ Influx.

NRXN3 NRXN1 NRXN2

1.11e-073168338891114
Pubmed

Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes.

DLL4 LEPR NOTCH1

1.11e-073168330886104
Pubmed

Effect of notch1,2,3 genes silicing on NF-κB signaling pathway of macrophages in patients with atherosclerosis.

NOTCH1 NOTCH2 NOTCH3

1.11e-073168327697639
Pubmed

Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses.

NRXN3 NRXN1 NRXN2

1.11e-073168331005376
Pubmed

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.

DLL4 JAG2 NOTCH2

1.11e-073168328572448
Pubmed

Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.

NRXN3 NRXN1 NRXN2

1.11e-073168311944992
Pubmed

Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis.

NRXN3 NRXN1 NRXN2

1.11e-073168333058888
Pubmed

Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules.

NRXN3 NRXN1 NRXN2

1.11e-073168317035546
Pubmed

Neurexins: three genes and 1001 products.

NRXN3 NRXN1 NRXN2

1.11e-07316839448462
Pubmed

Deletion of α-neurexin II results in autism-related behaviors in mice.

NRXN3 NRXN1 NRXN2

1.11e-073168325423136
Pubmed

Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate.

NOTCH1 NOTCH2 NOTCH3

1.11e-07316837615640
Pubmed

The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium.

NOTCH1 NOTCH2 NOTCH3

1.11e-07316837918097
Pubmed

The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice.

NRXN3 NRXN1 NRXN2

1.11e-073168330858964
Pubmed

Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction.

JAG2 NOTCH1 NOTCH2

1.11e-073168318458347
Pubmed

O-Fucose and Fringe-modified NOTCH1 extracellular domain fragments as decoys to release niche-lodged hematopoietic progenitor cells.

DLL4 NOTCH1 NOTCH2

1.11e-073168333351914
Pubmed

Overlapping but distinct roles for NOTCH receptors in human cardiovascular disease.

NOTCH1 NOTCH2 NOTCH3

1.11e-073168329767458
Pubmed

Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing.

NRXN3 NRXN1 NRXN2

1.11e-073168312036300
Pubmed

Neurexin gene family variants as risk factors for autism spectrum disorder.

NRXN3 NRXN1 NRXN2

1.11e-073168329045040
Pubmed

The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation.

NOTCH1 NOTCH2 NOTCH3

1.11e-07316837698746
Pubmed

Structural and functional characterization of the IgSF21-neurexin2α complex and its related signaling pathways in the regulation of inhibitory synapse organization.

NRXN3 NRXN1 NRXN2

1.11e-073168338571813
Pubmed

Deletion of β-Neurexins in Mice Alters the Distribution of Dense-Core Vesicles in Presynapses of Hippocampal and Cerebellar Neurons.

NRXN3 NRXN1 NRXN2

1.11e-073168335173587
Pubmed

The Notch-mediated circuitry in the evolution and generation of new cell lineages: the tooth model.

JAG2 NOTCH1 NOTCH2

1.11e-073168337330998
Pubmed

Complementary and combinatorial patterns of Notch gene family expression during early mouse development.

NOTCH1 NOTCH2 NOTCH3

1.11e-07316838645602
Pubmed

alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction.

NRXN3 NRXN1 NRXN2

1.11e-073168316406382
Pubmed

Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals.

NRXN3 NRXN1 NRXN2

1.11e-073168326446217
Pubmed

Endogenous β-neurexins on axons and within synapses show regulated dynamic behavior.

NRXN3 NRXN1 NRXN2

1.11e-073168334133920
Pubmed

Helicobacter pylori Infection of Gastric Epithelial Cells Affects NOTCH Pathway In Vitro.

DLL4 NOTCH1 NOTCH2

1.11e-073168327073072
Pubmed

Expression of Notch1 to -4 and their ligands in renal cell carcinoma: a tissue microarray study.

NOTCH1 NOTCH2 NOTCH3

1.11e-073168321471519
Pubmed

Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex.

NRXN3 NRXN1 NRXN2

1.11e-073168328013231
Pubmed

Ketamine Restores Thalamic-Prefrontal Cortex Functional Connectivity in a Mouse Model of Neurodevelopmental Disorder-Associated 2p16.3 Deletion.

NRXN3 NRXN1 NRXN2

1.11e-073168331812984
Pubmed

β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling.

NRXN3 NRXN1 NRXN2

1.11e-073168326213384
Pubmed

Gene Expression and Missplicing in the Corneal Endothelium of Patients With a TCF4 Trinucleotide Repeat Expansion Without Fuchs' Endothelial Corneal Dystrophy.

MBNL1 AKAP13 KIF13A

1.11e-073168331469403
Pubmed

Neurexins are differentially expressed in the embryonic nervous system of mice.

NRXN3 NRXN1 NRXN2

1.11e-07316837722633
Pubmed

Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia.

DLL4 JAG2 ADAM17 NOTCH1 NOTCH2 NOTCH3

1.20e-0748168635247391
Pubmed

Notch signaling controls liver development by regulating biliary differentiation.

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

1.50e-0726168519369401
Pubmed

Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development.

JAG2 NOTCH1 NOTCH2 NOTCH3

1.69e-0711168416607638
Pubmed

Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators.

JAG2 NOTCH1 NOTCH2 NOTCH3

1.69e-0711168410878608
Pubmed

Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions.

JAG2 NOTCH1 NOTCH2 NOTCH3

1.69e-0711168412866128
Pubmed

Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development.

DLL4 MUC5AC NOTCH1 NOTCH2 NOTCH3

1.84e-0727168521791528
Pubmed

Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells.

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

2.68e-0729168525535917
Pubmed

Notch signaling regulates ovarian follicle formation and coordinates follicular growth.

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

3.20e-0730168524552588
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

SP2 NSD2 WRN NSD1 ZNF205 DIDO1 ZNF318 FANCM CHAMP1 LDLR THOC6 RING1 SETD2 WIZ TRIM28 ASPH RNF20 EHMT1 CKAP2 TAF6 TET3 ZMYM3

3.23e-0712941682230804502
Pubmed

Jagged1 is Essential for Radial Glial Maintenance in the Cortical Proliferative Zone.

JAG2 NOTCH1 NOTCH2 NOTCH3

3.63e-0713168431202705
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

NPC1 ITGA1 ADGRE2 ADAM12 LDLR JAG2 IGF1R TENM3 TRIM28 ASPH RIMOC1 LRP1 LRP5 ADAM17 LTBP3 CKAP2 SLC33A1 NOTCH1 NOTCH2 NOTCH3 SORL1

3.90e-0712011682135696571
Pubmed

Notch signaling pathway regulates the growth and the expression of inflammatory cytokines in mouse basophils.

NOTCH1 NOTCH2 NOTCH3

4.41e-074168328669409
Pubmed

Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): evolutionary conservation of multiple expression domains in amphioxus and vertebrates.

NOTCH1 NOTCH2 NOTCH3

4.41e-074168311401408
Pubmed

Selective modulation of integrin-mediated cell migration by distinct ADAM family members.

ADAM19 ADAM12 ADAM17

4.41e-074168316079176
Pubmed

Functional conservation of mouse Notch receptor family members.

NOTCH1 NOTCH2 NOTCH3

4.41e-07416838898100
Pubmed

Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing.

NOTCH1 NOTCH2 NOTCH3

4.41e-074168311978185
Pubmed

CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins.

NRXN3 NRXN1 NRXN2

4.41e-07416838786425
Pubmed

Targeting of Scavenger Receptors Stabilin-1 and Stabilin-2 Ameliorates Atherosclerosis by a Plasma Proteome Switch Mediating Monocyte/Macrophage Suppression.

STAB2 LDLR STAB1

4.41e-074168336325910
Pubmed

Deregulated expression of Notch receptors in human hepatocellular carcinoma.

NOTCH1 NOTCH2 NOTCH3

4.41e-074168317920003
Pubmed

Neurexins regulate presynaptic GABAB-receptors at central synapses.

NRXN3 NRXN1 NRXN2

4.41e-074168333888718
Pubmed

Notch pathway regulates female germ cell meiosis progression and early oogenesis events in fetal mouse.

JAG2 NOTCH1 NOTCH2

4.41e-074168324398584
Pubmed

Prognostic roles of mRNA expression of notch receptors in non-small cell lung cancer.

NOTCH1 NOTCH2 NOTCH3

4.41e-074168328061457
Pubmed

Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2.

DLL4 NOTCH1 NOTCH2

4.41e-074168332820046
Pubmed

Evolutionary analysis of vertebrate Notch genes.

NOTCH1 NOTCH2 NOTCH3

4.41e-074168311466531
Pubmed

Abnormal expression pattern of Notch receptors, ligands, and downstream effectors in the dorsolateral prefrontal cortex and amygdala of suicidal victims.

NOTCH1 NOTCH2 NOTCH3

4.41e-074168324151014
Pubmed

SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRα1 and RET.

GDNF GFRA1 SORL1

4.41e-074168323333276
Pubmed

Neurexins cluster Ca2+ channels within the presynaptic active zone.

NRXN3 NRXN1 NRXN2

4.41e-074168332134527
Pubmed

Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias.

NOTCH1 NOTCH2 NOTCH3

4.41e-074168318184405
Pubmed

Detection of Notch signaling molecules in cemento-ossifying fibroma of the jaws.

JAG2 NOTCH1 NOTCH3

4.41e-074168320040020
InteractionNTN5 interactions

LDLR JAG2 LRP2 LTBP4 NOTCH1 NOTCH2 NOTCH3 SORL1

1.02e-11241638int:NTN5
InteractionFBXO2 interactions

NPC1 GAS6 SHMT1 LAMC2 ITGA1 LEPR JAG2 IGF1R TENM3 LRP2 ADAM17 IL17RA PAX4 OLFM2 LTBP4 NOTCH1 NOTCH2 NOTCH3 SORL1

1.01e-0941116319int:FBXO2
InteractionZDHHC15 interactions

THSD7A ZNF318 ZNF77 RESF1 NRXN1 ATRNL1 LRP1 LRP2 LTBP3 MUC5AC SPINK5

5.79e-0912516311int:ZDHHC15
InteractionZNF74 interactions

VWCE JAG2 TRIM28 LTBP4 NOTCH1 NOTCH3 SORL1

8.91e-09341637int:ZNF74
InteractionPRG2 interactions

ADAMTS1 GAS6 LAMC2 LDLR JAG2 LRP5 IL17RA LTBP3 OLFM2 LTBP4 NOTCH1 ZMYM3 NOTCH2 NOTCH3 SORL1

1.15e-0828516315int:PRG2
InteractionIGFL3 interactions

LDLR JAG2 LRP2 LRP5 NOTCH1 NOTCH2 NOTCH3 SORL1

1.64e-07751638int:IGFL3
InteractionEGFL7 interactions

DLK1 VWCE IGF1R LRP3 OLFM2 NOTCH1 NOTCH2 NOTCH3

2.02e-07771638int:EGFL7
InteractionEDN3 interactions

GAS6 LDLR JAG2 LRP5 IL17RA OLFM2 NOTCH1 NOTCH2 SORL1

2.34e-071081639int:EDN3
InteractionCCN6 interactions

LDLR IL17RA NOTCH1 NOTCH2 SORL1

3.45e-07191635int:CCN6
InteractionZFP41 interactions

LDLR LRP1 LRP2 LTBP4 NOTCH2 NOTCH3 SORL1

3.75e-07571637int:ZFP41
InteractionZNF627 interactions

TRAF1 DLK1 VWCE TRIM28 NOTCH2

4.57e-07201635int:ZNF627
InteractionWNT10A interactions

LDLR WNT16 LRP5 LTBP3 NOTCH1 NOTCH2

4.82e-07371636int:WNT10A
InteractionSDF2L1 interactions

NPC1 ADAM19 GRK6 GAS6 ZNRF4 JAG2 IGF1R LRP5 ADAM17 IL17RA OLFM2 ALK SORL1

2.29e-0632216313int:SDF2L1
InteractionWNT3A interactions

LDLR JAG2 WNT16 LRP1 NOTCH1 NOTCH2

2.68e-06491636int:WNT3A
InteractionZNF408 interactions

ZNF473 VWCE CHAMP1 LDLR LRP2 LTBP4 NOTCH2 NOTCH3 SORL1

2.81e-061451639int:ZNF408
InteractionIGSF5 interactions

LDLR NOTCH1 NOTCH2 NOTCH3

3.88e-06141634int:IGSF5
InteractionTIMP3 interactions

VWCE LDLR LRP2 LRP5 ADAM17 NOTCH2 SORL1

8.47e-06901637int:TIMP3
InteractionCFC1 interactions

ADAM19 LRP5 IL17RA OLFM2 LTBP4 NOTCH1 NOTCH2 SORL1

8.63e-061261638int:CFC1
InteractionLGALS1 interactions

NPC1 FAT3 ITGA1 LDLR JAG2 IGF1R TENM3 LRP2 NOTCH1 NOTCH2 NOTCH3 SORL1

1.72e-0533216312int:LGALS1
InteractionZNF224 interactions

TRIM28 LRP2 NOTCH3 SORL1

1.81e-05201634int:ZNF224
InteractionSLURP1 interactions

LDLR LEPR IGF1R WNT16 IL17RA OLFM2 NOTCH2 SORL1

2.29e-051441638int:SLURP1
InteractionZNF324 interactions

ZNF467 VWCE TRIM28 LRP3 NOTCH2

3.41e-05461635int:ZNF324
InteractionTAFA2 interactions

LDLR LEPR TENM3 ATRNL1 SORL1

3.79e-05471635int:TAFA2
InteractionZNF761 interactions

ZNF467 TRIM28 NOTCH2

4.21e-0591633int:ZNF761
InteractionZNF480 interactions

ZNF467 TRIM28 NOTCH2

4.21e-0591633int:ZNF480
InteractionZNF587B interactions

ZNF467 TRIM28 NOTCH2

4.21e-0591633int:ZNF587B
InteractionZNF707 interactions

TRIM28 LTBP4 NOTCH1 NOTCH2 NOTCH3 SORL1

4.36e-05791636int:ZNF707
InteractionTRIM66 interactions

ERBB4 FAT3 GAS6 ZNF318 SETD2 DROSHA LTBP4 GARRE1 NOTCH2

4.53e-052051639int:TRIM66
InteractionPIGA interactions

TRAF1 ZNRF4 VWCE LRP3 IL17RA

4.66e-05491635int:PIGA
InteractionFOXD4L6 interactions

LDLR LTBP4 NOTCH1 NOTCH2 SORL1

4.66e-05491635int:FOXD4L6
InteractionLYZL1 interactions

LDLR JAG2 IGF1R WNT16 LRP5 IL17RA SORL1

4.95e-051181637int:LYZL1
InteractionADAM32 interactions

ADAMTS1 GAS6 JAG2 NOTCH3

5.37e-05261634int:ADAM32
InteractionSIRPD interactions

GAS6 JAG2 LRP5 IL17RA NOTCH1 SORL1

7.04e-05861636int:SIRPD
InteractionZSCAN21 interactions

ZNF787 ZNF473 ZNF467 VWCE ZSCAN10 NOTCH2 SORL1

8.29e-051281637int:ZSCAN21
InteractionZNF517 interactions

TRIM28 LRP2 LTBP4 SORL1

8.37e-05291634int:ZNF517
InteractionZNF563 interactions

TRIM28 LTBP4 SORL1

1.08e-04121633int:ZNF563
InteractionANKRD36B interactions

CHAMP1 ARFGAP3 LRP1 LRP2 SORL1

1.24e-04601635int:ANKRD36B
InteractionZNF382 interactions

ZNF787 ZNF473 ZSCAN10 TRIM28

1.41e-04331634int:ZNF382
InteractionZNF101 interactions

ZNF467 ZNF16 TRIM28 LRP3

1.41e-04331634int:ZNF101
InteractionNOTCH2 interactions

ZNF787 SP2 ADAMTS1 DTX3 DLK1 JAG2 ASPH LTBP4 GARRE1 NOTCH1 NOTCH2 NOTCH3

1.75e-0442316312int:NOTCH2
InteractionSOST interactions

LRP2 LRP5 TNKS SORL1

1.78e-04351634int:SOST
InteractionOIT3 interactions

GAS6 ZNF77 JAG2 WNT16 LTBP4

1.82e-04651635int:OIT3
InteractionAPBB1 interactions

WASL IGF1R NRXN1 LRP1 LRP2 SYP ALK NOTCH1

1.92e-041951638int:APBB1
InteractionCLEC2B interactions

JAG2 ASPH LRP5 ADAM17 NOTCH1 NOTCH2 SORL1

1.96e-041471637int:CLEC2B
InteractionDLK2 interactions

LDLR LRP2 NOTCH1 NOTCH3

1.99e-04361634int:DLK2
InteractionGREM2 interactions

LDLR LRP2 NOTCH2 SORL1

2.21e-04371634int:GREM2
InteractionPPP1R12B interactions

ANK2 TNKS NOTCH1 NOTCH2 NOTCH3

2.25e-04681635int:PPP1R12B
InteractionMARCHF1 interactions

GRK6 VPS9D1 NOTCH1 NOTCH2 NOTCH3

2.58e-04701635int:MARCHF1
InteractionZNF813 interactions

ZNF467 TRIM28 NOTCH2

2.69e-04161633int:ZNF813
InteractionADAM23 interactions

ADAM19 PRRT2 ADAM12

2.69e-04161633int:ADAM23
InteractionTOP3B interactions

NPC1 SPIRE2 NSD2 GRK6 WRN NSD1 LDLR PLEKHM1 DHX30 JAG2 IGF1R OVOL1 WIZ TRIM28 PPP1R15B EHMT1 LRP3 LRP5 AKAP13 HMGXB3 LTBP3 TNFAIP3 LTBP4 NOTCH1 NOTCH2

3.20e-04147016325int:TOP3B
InteractionMAML2 interactions

NOTCH1 NOTCH2 NOTCH3

3.25e-04171633int:MAML2
InteractionJAG1 interactions

JAG2 NOTCH1 NOTCH2 NOTCH3

3.31e-04411634int:JAG1
Cytoband5q35

GRK6 NSD1 ADAMTS12

8.08e-052316835q35
CytobandEnsembl 112 genes in cytogenetic band chr5p13

GDNF ADAMTS12 DROSHA RIMOC1 C7

1.67e-041391685chr5p13
GeneFamilyLow density lipoprotein receptors

LDLR LRP1 LRP2 LRP3 LRP5

1.59e-08131225634
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF787 SP2 ZNF266 ZNF473 ZNF205 ZNF318 BCL11A ZNF467 CHAMP1 ZNF77 ZNF16 OVOL1 ZSCAN10 WIZ ZFP92 ZNF415

2.64e-057181221628
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ADAM19 ADAM29 ADAM12 ADAM17

3.07e-0527122447
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

NSD2 NSD1 SETD2 EHMT1

7.82e-05341224487
GeneFamilyLatent transforming growth factor beta binding proteins

LTBP3 LTBP4

2.69e-0441222628
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ITGA1 ADGRE2 CR1 LEPR IGF1R CSF3R LRP1 ADAM17 IL17RA ALK

3.40e-0439412210471
GeneFamilyCD molecules|Adhesion G protein-coupled receptors, subfamily E

ADGRE2 ADGRE1

4.46e-0451222915
GeneFamilyPHD finger proteins

NSD2 NSD1 DIDO1 TRIM28

3.23e-0390122488
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

3.73e-08161645MM1296
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

DLL4 JAG2 NOTCH1 NOTCH2 NOTCH3

3.73e-08161645M2207
CoexpressionGSE25085_FETAL_BM_VS_ADULT_BM_SP4_THYMIC_IMPLANT_DN

TRAF1 STAB2 ADAM19 SHMT1 CSF3R ATRNL1 ADAM17 TNFAIP3 SORL1

4.80e-061991649M8070
CoexpressionGSE29618_MONOCYTE_VS_MDC_UP

GRK6 RNF19B CR1 LDLR CSF3R LRP1 ADGRE1 NOTCH2 SORL1

5.00e-062001649M4948
CoexpressionNABA_MATRISOME

ADAM19 ADAMTS1 GAS6 LAMC2 ADAM29 TECTA VWCE ADAM12 GDNF ADAMTS12 EYS SEMA5B WNT16 CST5 SCUBE3 ADAM17 LTBP3 LTBP4 MUC5AC ANGPTL5

6.96e-06102616420M5889
CoexpressionWANG_TNF_TARGETS

TRAF1 IGDCC3 TNFAIP3 NOTCH3

1.98e-05261644M2308
CoexpressionGSE9988_ANTI_TREM1_VS_LOW_LPS_MONOCYTE_DN

TRAF1 PDSS1 RNF19B SAMSN1 LDLR PPP1R15B TNFAIP3 PTTG1IP

3.68e-051981648M5847
CoexpressionGSE9988_ANTI_TREM1_VS_LPS_MONOCYTE_DN

TRAF1 PDSS1 RNF19B SAMSN1 LDLR PPP1R15B TNFAIP3 PTTG1IP

3.81e-051991648M5845
CoexpressionGSE11961_FOLLICULAR_BCELL_VS_MARGINAL_ZONE_BCELL_DN

THSD7A ZNF318 STAB1 PPP1R15B PAX4 SLC33A1 RECK PADI3

3.95e-052001648M9373
CoexpressionGSE4748_CTRL_VS_CYANOBACTERIUM_LPSLIKE_STIM_DC_3H_UP

ADAM19 GRK6 BCL11A SAMSN1 IGF1R RNF20 AKAP13 IL17RA

3.95e-052001648M6477
CoexpressionTRAVAGLINI_LUNG_OLR1_CLASSICAL_MONOCYTE_CELL

TRAF1 ADAM19 PDSS1 EML4 RNF19B SAMSN1 ADGRE2 VPS9D1 CSF3R ARFGAP3 PPP1R15B ASPH ADAM17 TNFAIP3 NOTCH2

5.30e-0572416415M41700
CoexpressionLAKE_ADULT_KIDNEY_C2_PODOCYTES

THSD7A EML4 ITGA1 CR1 IGF1R TENM3 UNC5C KIF13A

5.95e-052121648M39221
CoexpressionNABA_MATRISOME

ADAM19 ADAMTS1 GAS6 LAMC2 ADAM29 TECTA VWCE ADAM12 GDNF ADAMTS12 SEMA5B WNT16 CST5 SCUBE3 ADAM17 LTBP3 LTBP4 MUC5AC

6.44e-05100816418MM17056
CoexpressionGSE6269_E_COLI_VS_STREP_PNEUMO_INF_PBMC_DN

NPC1 CAMP RNF19B ZNF318 CR1 STAB1 CSF3R

9.38e-051681647M5662
CoexpressionAtlasStromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5

THSD7A ADAMTS1 GAS6 ITGA1 ADAM12 LEPR ADAMTS12 TENM3 ATRNL1 LRP1 LTBP3 C7 LTBP4 RECK NOTCH3

3.25e-0646616315GSM777050_500
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 GFRA1 ADAMTS12 TENM3 ATRNL1 UNC5C LRP1 C7 LTBP4

2.65e-0919116510a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 GFRA1 ADAMTS12 TENM3 ATRNL1 UNC5C LRP1 C7 LTBP4

2.79e-09192165109093a9e94a25682d109a7f6edc256a25a61103a0
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 GFRA1 ADAMTS12 TENM3 ATRNL1 UNC5C LRP1 C7 LTBP4

2.79e-09192165109ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 GFRA1 ADAMTS12 TENM3 ATRNL1 UNC5C LRP1 C7 LTBP4

2.93e-0919316510f1199518c3626fd29bfce65070dd21a660671213
ToppCellLPS-antiTNF-Stromal_mesenchymal|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK2 ADAMTS1 FAT3 GFRA1 ADAMTS12 TENM3 UNC5C LRP1 C7 LTBP4

3.08e-09194165106e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 GDNF GFRA1 ADAMTS12 NRXN3 TENM3 ATRNL1 UNC5C C7

3.08e-091941651090efdbd7f1c85fd7fd622b10340250b1d8fc1197
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 GDNF GFRA1 ADAMTS12 NRXN3 TENM3 ATRNL1 UNC5C C7

3.08e-0919416510df82cce5ebeb73740b02cf816c6df82253cfd566
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ANK2 ADAMTS1 ADAMTS12 TENM3 SYTL4 UNC5C LRP1 LRP3 C7 LTBP4

3.93e-0919916510a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 GFRA1 ADAMTS12 TENM3 ATRNL1 UNC5C C7 LTBP4

3.83e-08189165971397e993a77d70b2eeede240bdfc7660b558987
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 GFRA1 ADAMTS12 TENM3 ATRNL1 UNC5C C7 LTBP4

3.83e-0818916594eea4759520c312bd17a681034d8074e47093d2b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 GFRA1 ADAMTS12 TENM3 ATRNL1 UNC5C LRP1 C7

4.01e-0819016592306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAT3 ITGA1 ADAM12 ADAMTS12 TENM3 ATRNL1 UNC5C C7 NOTCH3

4.01e-08190165970c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 GFRA1 ADAMTS12 TENM3 ATRNL1 UNC5C LRP1 C7

4.01e-0819016591f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK2 FAT3 GFRA1 ADAMTS12 TENM3 UNC5C LRP1 C7 LTBP4

4.20e-081911659b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 GFRA1 ADAMTS12 TENM3 ATRNL1 LRP1 C7 LTBP4

4.20e-08191165939092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAT3 ITGA1 ADAM12 ADAMTS12 TENM3 ATRNL1 UNC5C LRP1 C7

4.20e-081911659107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 GFRA1 ADAMTS12 TENM3 ATRNL1 LRP1 C7 LTBP4

4.20e-081911659ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAT3 ITGA1 ADAM12 ADAMTS12 TENM3 ATRNL1 UNC5C LRP1 C7

4.20e-081911659bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK2 ADAMTS1 FAT3 ADAMTS12 TENM3 UNC5C LRP1 C7 LTBP4

4.39e-0819216593d0cb19f037f604253d7d728689aeaa94251e92b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 GFRA1 ADAMTS12 TENM3 ATRNL1 LRP1 C7 LTBP4

4.39e-081921659d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK2 FAT3 GFRA1 ADAMTS12 TENM3 UNC5C LRP1 C7 LTBP4

4.39e-081921659dcd924d6eb67d33ee9f5d3e8ab6e1d4283d6b708
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK2 FAT3 GFRA1 ADAMTS12 TENM3 UNC5C LRP1 C7 LTBP4

4.59e-081931659fb28717fadd06c3840636d25409ce80c9254bd34
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK2 FAT3 GFRA1 ADAMTS12 TENM3 UNC5C LRP1 C7 LTBP4

4.80e-08194165989b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK2 FAT3 GFRA1 ADAMTS12 TENM3 UNC5C LRP1 C7 LTBP4

4.80e-08194165960622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 ADAMTS12 NRXN3 TENM3 ATRNL1 UNC5C C7 LTBP4

5.01e-081951659803f714d91f2d97ecbee8c15a5139fd9310f66c7
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAMTS12 TENM3 ATRNL1 UNC5C LRP1 C7 LTBP4 NOTCH3

5.01e-081951659edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 ADAMTS12 NRXN3 TENM3 ATRNL1 UNC5C C7 LTBP4

5.01e-0819516594f70157d42a16ff0259bc24a62803c4df4285c44
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 ADAMTS12 TENM3 ATRNL1 UNC5C LRP1 C7 LTBP4

5.01e-081951659d9a5c75d31c6e8bb1e1ab7fd115ac5deb5fb1c8d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 ADAMTS12 TENM3 ATRNL1 UNC5C LRP1 C7 LTBP4

5.24e-081961659a12dd986df65c36f248cf10815c3b8b6238613b0
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS1 ITGA1 ADGRE2 ADAM12 GFRA1 ADAMTS12 TENM3 ATRNL1 C7

5.24e-0819616593a6c942e2907aa07b5e12dbf9019d18f7bfca507
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 ADAMTS12 TENM3 ATRNL1 UNC5C LRP1 C7 LTBP4

5.24e-0819616593e6803587d8566fd08cb8b290be3b6461743d79c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS1 ITGA1 ADGRE2 ADAM12 GFRA1 ADAMTS12 TENM3 ATRNL1 C7

5.24e-081961659bba88e91cd3e3a6f5a9b443e3a4da33c5b455e70
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS1 ITGA1 ADAM12 GFRA1 ADAMTS12 TENM3 ATRNL1 C7 LTBP4

5.47e-08197165909946ee8dfb15a2a32da06e5b331f3277ee934f4
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 ADAMTS12 TENM3 ATRNL1 UNC5C LRP1 C7 LTBP4

5.47e-081971659b349f8e96d61a4c296af64711e11fc44459a9413
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 ADAMTS12 TENM3 ATRNL1 UNC5C LRP1 C7 LTBP4

5.47e-0819716596d027119a5f7ca2aac1b10837e43f9a2bb54db85
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 ADAMTS12 TENM3 ATRNL1 UNC5C LRP1 C7 LTBP4

5.47e-081971659c2e390653d5dee7e731c1840cfdab41987dede9b
ToppCellCOVID-19_Mild-Classical_Monocyte|COVID-19_Mild / Disease condition and Cell class

CR1 LDLR STAB1 CSF3R LRP1 IL17RA KIF13A TET3 SORL1

5.71e-08198165930ada3de865b6fb2b14196a1cbfd4740c6a57ce3
ToppCellParenchymal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ANK2 ADAMTS1 FAT3 ITGA1 ADAMTS12 TENM3 UNC5C LRP1 C7

6.23e-082001659cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 GDNF GFRA1 ADAMTS12 NRXN1 TENM3 ATRNL1 C7

7.17e-081451658051d964ff6bdc12ba3f0459d3e6ab16fa9507b0b
ToppCellfacs-Liver-Non-hepatocytes-24m-Myeloid-neutrophil|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRE2 IGF1R CSF3R IL17RA NOTCH2 PADI3 FOXD4 SORL1

1.77e-071631658abec4389cd88252449f110fe95416d67424b403a
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_pre_proliferating_SCP_(4)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ERBB4 DLK1 ADAM12 GFRA1 GFRA3 NRXN1 LRP2 ALK

3.32e-07177165859726bfd98f656fdcedf448a7e2e76a9bfad8285
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC10A4 ITGA1 ATRNL1 UNC5C LRP1 ZFP92 C7 LTBP4

3.94e-0718116586d1f1ad35778a2a227f966f11f6edd8e89452576
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAT3 ITGA1 ADAM12 GFRA1 ADAMTS12 LRP1 C7 LTBP4

3.94e-071811658c62b0a2422377ffadaab63edd538e87a06fa5017
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAT3 ITGA1 ADAM12 GFRA1 ADAMTS12 LRP1 C7 LTBP4

3.94e-071811658c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 GFRA1 ADAMTS12 TENM3 ATRNL1 UNC5C C7

4.46e-071841658c5436a8e45f471b8d1301abbe9c7879204537f52
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 GFRA1 ADAMTS12 ATRNL1 UNC5C LRP1 C7 LTBP4

4.46e-071841658e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCell5'-Adult-LargeIntestine-Neuronal-Glial_mature|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANK2 GDNF GFRA1 GFRA3 NRXN3 NRXN1 TENM3 ALK

4.65e-071851658f607b6ee579562e2f92103fa5c7053df0170a229
ToppCell5'-Adult-LargeIntestine-Neuronal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANK2 GDNF GFRA1 GFRA3 NRXN3 NRXN1 TENM3 ALK

4.65e-071851658317f2c854f00aa5957319b818c85eeed7d72ec7f
ToppCell5'-Adult-LargeIntestine-Neuronal-Glial_mature-Adult_Glia|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANK2 GDNF GFRA1 GFRA3 NRXN3 NRXN1 TENM3 ALK

4.65e-0718516587bb8fdfe04f85d25056380ec58222366de323a21
ToppCellCOVID-19-kidney-Fibroblast-1|COVID-19 / Disease (COVID-19 only), tissue and cell type

ITGA1 ADGRE2 ADAM12 GFRA1 ADAMTS12 TENM3 ATRNL1 C7

5.04e-07187165876bfe8c42430a230a8bdf299575c444fb7780f24
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK2 FAT3 ADAMTS12 TENM3 UNC5C LRP1 C7 LTBP4

5.46e-071891658a153b83314cf52808f685296cff8c95af3f4983d
ToppCellcellseq-Immune-Hematopoietic-Granulocytic-Neutrophil|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SAMSN1 ADGRE2 CR1 RESF1 CSF3R IL17RA TNFAIP3 SORL1

5.46e-071891658fedab592be1d6520325b8c1b659b0a4dc3f4fe4d
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK2 FAT3 ADGRE2 GFRA1 UNC5C LRP1 C7 LTBP4

5.46e-0718916582a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAM19 RNF19B SAMSN1 ADGRE2 CR1 VPS9D1 CSF3R IL17RA

5.69e-07190165857800d807785b9d539b47945a0a74631f5e88a06
ToppCellwk_08-11-Epithelial-PNS-Schwann_precursor|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ERBB4 ADAM12 GFRA1 NRXN1 NRXN2 WNT16 ALK NOTCH1

5.69e-0719016584a777d8aa19cadd3b61b023772df142421a89113
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 GFRA1 ADAMTS12 TENM3 ATRNL1 LRP1 C7 LTBP4

5.92e-071911658a6c57627077fa980b7ec1d3894b5f31bfb11b738
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

ADAMTS1 FAT3 ADAM12 ADAMTS12 SEMA5B UNC5C LTBP4 NOTCH3

5.92e-07191165878c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 GFRA1 ADAMTS12 TENM3 ATRNL1 LRP1 C7 LTBP4

5.92e-0719116588f6d592edc32fdb901af30501d4360512334e8c2
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 GFRA1 ADAMTS12 TENM3 ATRNL1 LRP1 C7 LTBP4

6.15e-071921658bc84b9ce01b4d826a682842ab8a395dac9b91183
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 GFRA1 ADAMTS12 TENM3 ATRNL1 LRP1 C7 LTBP4

6.15e-0719216585105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 GFRA1 ADAMTS12 TENM3 ATRNL1 LRP1 C7 LTBP4

6.15e-0719216580ab1176cfbb0de8dd1f22c6e2c41265cf6c10ee1
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK2 FAT3 ADAMTS12 TENM3 UNC5C LRP1 C7 LTBP4

6.15e-0719216586f4ef24dab544681304b7f8a9dc073e7edaa4cf5
ToppCellLPS_only-Stromal_mesenchymal|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK2 ADAMTS1 FAT3 TENM3 UNC5C LRP1 C7 LTBP4

6.15e-071921658162d8b5858d150ecbbd1c9bf2b19c6c9cd50a158
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

NPC1 EML4 LAMC2 ADGRE2 LDLR TENM3 ARFGAP3 AKAP13

6.15e-0719216588b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK2 FAT3 ADAMTS12 TENM3 UNC5C LRP1 C7 LTBP4

6.15e-071921658deeecd26972241846b4cb998edf0c7a87ff0c4df
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS1 ITGA1 GFRA1 ADAMTS12 TENM3 ATRNL1 C7 LTBP4

6.40e-071931658c8c21eee8c6c086dc2faf416669cd4a002870fbe
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS1 ITGA1 GFRA1 ADAMTS12 TENM3 ATRNL1 C7 LTBP4

6.40e-0719316585b602b1702283184bd3943c2a6f2290b7c37e407
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 GFRA1 ADAMTS12 TENM3 ATRNL1 LRP1 C7 LTBP4

6.66e-07194165881713e0409e8be695ba5dfdc67a997b33435dd9e
ToppCellControl-Classical_Monocyte|Control / Disease condition and Cell class

ZNF467 CR1 STAB1 CSF3R LRP1 IL17RA KIF13A SORL1

6.66e-0719416589e33e1b54b4114f9e6981819834bb796ed7192b5
ToppCellfacs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS1 DLL4 ITGA1 ADGRE2 STAB1 LRP5 GARRE1 NOTCH1

6.66e-071941658f159ef8541d75a4e98468947f231bb463bec922c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 GFRA1 ADAMTS12 TENM3 ATRNL1 LRP1 C7 LTBP4

6.66e-071941658627cffe2d448e74fc5df92e74e5b922a73304137
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 GFRA1 ADAMTS12 TENM3 ATRNL1 C7 LTBP4

6.66e-071941658cf0244a29934e515446ac917d3c30672b460fb04
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 GFRA1 ADAMTS12 TENM3 ATRNL1 LRP1 C7 LTBP4

6.66e-071941658e03ba6caed59fa64d4d9b042593469d4a6a3dc10
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 GFRA1 ADAMTS12 TENM3 ATRNL1 C7 LTBP4

6.66e-071941658ba7f971fb9a19423602da60770f23d9fead4a451
ToppCellTCGA-Blood_and_Bone_Marrow-Primary_Tumor-Diffuse_large_B-cell_lymphoma-DLBCL-1|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9

ADAM19 ANK2 DLL4 LAMC2 ADAM12 DIPK2B ADAMTS12 TENM3

6.66e-071941658eaeeb84576270cc3fc59002ba33bff9639bb0b02
ToppCelldistal-Hematologic-Classical_Monocyte-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SAMSN1 ADGRE2 ZNF467 CR1 STAB1 CSF3R TNFAIP3 SORL1

6.92e-07195165832c34741e35006b7238896fd04a497011297dd22
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 GFRA1 ADAMTS12 TENM3 ATRNL1 C7 LTBP4

6.92e-071951658cad6563cc51d212554152c727fc2c249c6a07e4d
ToppCellControl-Classical_Monocyte-cMono_2|Control / Disease condition and Cell class

STAB1 CSF3R PPP1R15B LRP1 AKAP13 IL17RA TNFAIP3 SORL1

6.92e-0719516580fea64ee3eedf3929abb0dd9c5f5fc72f181eed9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 GFRA1 ADAMTS12 TENM3 ATRNL1 C7 LTBP4

6.92e-071951658783bfa8110161cbd6def50ce849cae676c39c458
ToppCellSmart-seq2-thymus_(Smart-seq2)-myeloid-myeloid_monocytic|thymus_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GRK6 SAMSN1 ADGRE2 LDLR CSF3R ASPH IL17RA SORL1

6.92e-071951658ae98215b7b7f22f1aca690920ce6092dc4a3c7db
ToppCellSmart-seq2-thymus_(Smart-seq2)-myeloid-myeloid_monocytic-monocyte|thymus_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GRK6 SAMSN1 ADGRE2 LDLR CSF3R ASPH IL17RA SORL1

6.92e-0719516586fcab7aa4db958ccad0300adea9aaae52ace5bff
ToppCellControl-Lymphoid-T|Lymphoid / Disease state, Lineage and Cell class

ADAM19 EML4 MBNL1 SAMSN1 ADAM12 LDLR AKAP13 TNFAIP3

6.92e-0719516586687e579582d7a239bee80846de0cf827a6f6a62
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 GFRA1 ADAMTS12 ATRNL1 UNC5C LRP1 C7

7.19e-071961658ba869f7a86f37fd6d84d6ad69baca0e0faaf5887
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 GFRA1 ADAMTS12 ATRNL1 UNC5C LRP1 C7

7.19e-07196165830ad56d49000e4ddce73b4443b3994564bd1e2d6
ToppCellfacs-Thymus-Thymus_Epithelium|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK2 GAS6 TENM3 NRXN2 LRP1 LRP2 C7 LTBP4

7.19e-0719616586bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCellfacs-Thymus-Thymus_Epithelium-18m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK2 GAS6 TENM3 NRXN2 LRP1 LRP2 C7 LTBP4

7.19e-071961658c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ANK2 ADAMTS1 DLK1 TENM3 SYTL4 LRP1 C7 LTBP4

7.47e-071971658fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCellBL|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SAMSN1 ADGRE2 CR1 RESF1 CSF3R IL17RA TNFAIP3 SORL1

7.47e-0719716581acf0191fa0a25cd20bfd9ea7bf727a1555986a1
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANK2 ADAMTS1 LEPR GFRA1 LRP1 C7 LTBP4 ANGPTL5

7.47e-071971658c747c496ac090309b7f8a3e9d840928f12c83f2f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 GFRA1 ADAMTS12 TENM3 ATRNL1 LRP1 C7 LTBP4

7.47e-071971658ae0435f4b4a9cdedb1c201fc56921048390097bf
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 GFRA1 ADAMTS12 TENM3 ATRNL1 LRP1 C7 LTBP4

7.47e-07197165837f6b6f2809b952382eaebb642b0aad6371f4251
ToppCellcontrol-Myeloid-Non-resident_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ADGRE2 CR1 LDLR STAB1 CSF3R LRP1 PTTG1IP SORL1

7.47e-071971658df2fe36cb96e2565a9d21c24cb4e451e8befd4be
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 ADAM12 ADAMTS12 NRXN3 TENM3 ATRNL1 UNC5C C7

7.47e-07197165880e153790cef37b743e22a7370ff5b3a6abf147d
ToppCellCOVID-19_Severe-Classical_Monocyte|World / disease group, cell group and cell class

ITGA1 SAMSN1 CR1 STAB1 CSF3R LRP1 IL17RA KIF13A

7.47e-071971658344801997b89bd81d8d5c3c872934de523233a8d
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ERBB4 ADAM12 GFRA1 GFRA3 NRXN3 NRXN1 OLFM2 NOTCH1

7.76e-07198165836c97eb71b89bac01cabd6a8b728e5a20e52d2a3
ToppCellmild-HLA-DR-_S100A+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZNF467 CR1 STAB1 CSF3R ASPH LRP1 IL17RA KIF13A

8.06e-071991658d0d286eafe935f9b3aaba5b783e8911251121b4a
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ANK2 ADAMTS1 ADAMTS12 SYTL4 LRP1 C7 LTBP4 RECK

8.06e-07199165830d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_CCL|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SAMSN1 ADGRE2 CR1 CSF3R DNAJA4 PPP1R15B TNFAIP3 ADGRE1

8.06e-07199165852c06fcc112da21b1d914a896c04bde06fc756fe
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_granulocytic|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SAMSN1 ADGRE2 CR1 CSF3R ASPH IL17RA TNFAIP3 SORL1

8.06e-071991658119807ea333d1dc7743c6b9f03a2c63e09e19541
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_granulocytic-neutrophil|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SAMSN1 ADGRE2 CR1 CSF3R ASPH IL17RA TNFAIP3 SORL1

8.06e-071991658691e04871cd6cac0ea5fca1b7fd6421df9315db6
DrugCycloheximide [66-81-9]; Down 200; 14.2uM; HL60; HT_HG-U133A

ZNF473 ADAMTS1 NSD2 GAS6 BCL11A LDLR JAG2 IGF1R LRP3 NOTCH2

4.76e-07171164102723_DN
DrugAndrogen Antagonists

ERBB4 IGF1R NRXN1 NRXN2 UNC5C ADAM17 NOTCH2

1.16e-06751647ctd:D000726
DrugClorgyline hydrochloride [17780-75-5]; Down 200; 13uM; PC3; HT_HG-U133A

ZNF473 LAMC2 RO60 ADAM12 LDLR JAG2 ZNF16 TENM3 ADAM17 MUC5AC

1.37e-06192164106659_DN
Drugmonatepil

LDLR LRP1 LRP2 LRP3 SORL1

1.88e-06291645CID000060810
DrugDichlorodiphenyl Dichloroethylene

ERBB4 GDNF LDLR GFRA1 GJB1 IGF1R NRXN1 NRXN2 SYP ALK NOTCH2 NOTCH3

2.08e-0630216412ctd:D003633
DrugLinuron

ERBB4 GDNF IGF1R NRXN1 NRXN2 SYP NOTCH2 NOTCH3

4.20e-061281648ctd:D008044
Drugenzacamene

ERBB4 IGF1R NRXN1 NRXN2 UNC5C SYP ADAM17 NOTCH2

4.45e-061291648ctd:C038939
Drugoctylmethoxycinnamate

ERBB4 IGF1R NRXN1 NRXN2 UNC5C SYP ADAM17 NOTCH2

7.73e-061391648ctd:C118580
Drug(+) -Levobunolol hydrochloride [47141-41-3]; Up 200; 12.2uM; MCF7; HT_HG-U133A

STAB2 LAMC2 GRM2 CR1 LEPR ADAMTS12 OVOL1 WIZ LTBP4

1.35e-0519716493355_UP
DrugDubinidine [22964-77-8]; Down 200; 14.6uM; MCF7; HT_HG-U133A

ZNF787 ZNF473 GRK6 DIDO1 ZNF318 LDLR AKAP13 TNFAIP3 SLC33A1

1.41e-0519816496250_DN
DrugMetampicillin sodium salt [6489-61-8]; Down 200; 10.4uM; MCF7; HT_HG-U133A

ADAM19 NSD2 EML4 RNF19B NSD1 RO60 VPS9D1 KIF13A LTBP4

1.41e-0519816492286_DN
Drugbutylparaben

ERBB4 IGF1R NRXN1 NRXN2 UNC5C SYP ADAM17 NOTCH2

1.88e-051571648ctd:C038091
DrugTapi

DLK1 ADAM12 LDLR ADAM17 TNFAIP3 MUC5AC

2.47e-05801646CID003035404
DrugAC1L1GUQ

DLL4 DLK1 LDLR JAG2 NOTCH2

2.97e-05501645CID000003849
DrugAstemizole [68844-77-9]; Up 200; 8.8uM; PC3; HT_HG-U133A

NPC1 TRAF1 NSD2 RNF19B LDLR LRP3 ADAM17 NOTCH1

5.40e-0518216482049_UP
DrugTAPI-1

ERBB4 IGF1R SYP ADAM17 TNFAIP3

5.64e-05571645CID009827273
DrugPerphenazine [58-39-9]; Up 200; 10uM; PC3; HG-U133A

NPC1 WASL SHMT1 LDLR ADAM17 LTBP3 TNFAIP3 SLC33A1

6.06e-0518516481956_UP
DrugInsulin recombinant

IGF1R SYTL4 LRP2

7.70e-05121643DB00030
DrugSalbutamol [18559-94-9]; Down 200; 16.8uM; PC3; HT_HG-U133A

STAB2 NSD2 MBNL1 LDLR NRXN3 DNAJA4 AKAP13 KIF13A

8.15e-0519316483677_DN
DrugHydroxyzine dihydrochloride [2192-20-3]; Down 200; 9uM; PC3; HT_HG-U133A

ZNF205 LAMC2 RO60 ADAM12 IGF1R WIZ LRP1 NOTCH3

8.45e-0519416486660_DN
DrugAzapropazone [13539-59-8]; Down 200; 13.4uM; MCF7; HT_HG-U133A

PDE6B RNF19B SHMT1 RO60 LEPR LRP2 IL17RA NOTCH2

8.76e-0519516486522_DN
DrugUrapidil hydrochloride [64887-14-5]; Up 200; 9.4uM; HL60; HT_HG-U133A

STAB2 GAS6 DCT JAG2 NRXN2 LRP5 LTBP3 SPINK5

8.76e-0519516483078_UP
DrugClomiphene citrate (Z,E) [50-41-9]; Down 200; 6.6uM; PC3; HT_HG-U133A

SHMT1 ZNF205 LAMC2 RO60 BCL11A LDLR SETD2 NOTCH2

8.76e-0519516486648_DN
DrugFlunisolide [3385-03-3]; Down 200; 9.2uM; MCF7; HT_HG-U133A

DTX3 RO60 LEPR WIZ EHMT1 LRP3 ADAM17 LTBP4

8.76e-0519516483923_DN
DrugSulfameter [651-06-9]; Up 200; 14.2uM; HL60; HT_HG-U133A

ERBB4 ADAM19 NOL3 SHMT1 STAB1 VPS9D1 PAX4 NOTCH3

9.41e-0519716482712_UP
Drug0393-0188; Down 200; 10uM; PC3; HT_HG-U133A

ZNF473 NSD2 RNF19B BCL11A LDLR ASPH ADAM17 KIF13A

9.41e-0519716487510_DN
Drugnifedipine; Up 200; 10uM; MCF7; HG-U133A

ANK2 BCL11A STAB1 OVOL1 TNFAIP3 LTBP4 ALK NOTCH3

9.41e-051971648335_UP
DrugAnabasine [494-52-0]; Up 200; 24.6uM; HL60; HT_HG-U133A

STAB2 NOL3 VPS9D1 NRXN2 ASPH EHMT1 C7 ALK

9.41e-0519716482512_UP
DrugTrifluoperazine dihydrochloride [440-17-5]; Up 200; 8.4uM; PC3; HT_HG-U133A

ADAMTS1 GRK6 RNF19B NSD1 ZNF205 LAMC2 GRM2 MUC5AC

9.41e-0519716486341_UP
DrugVitexin [3681-93-4]; Up 200; 9.2uM; HL60; HT_HG-U133A

ZNF787 THSD7A ZNF473 RNF19B SHMT1 GRM2 IGF1R ALK

9.74e-0519816482155_UP
DrugBuspirone hydrochloride [33386-08-2]; Up 200; 9.4uM; PC3; HT_HG-U133A

LAMC2 ADGRE2 CR1 ADAM12 EHMT1 LRP2 PAX4 TNFAIP3

9.74e-0519816486743_UP
DrugSulfabenzamide [127-71-9]; Down 200; 14.4uM; MCF7; HT_HG-U133A

ZNF473 PDE6B RNF19B ZNF205 DIDO1 JAG2 DNAJA4 AKAP13

9.74e-0519816484979_DN
DrugDO 897/99; Down 200; 8.2uM; MCF7; HT_HG-U133A

GRK6 RNF19B ZNF205 RO60 DHX30 LRP3 HMGXB3 SORL1

9.74e-0519816482877_DN
DrugInsulin, porcine

IGF1R SYTL4 LRP2

9.95e-05131643DB00071
DrugTropicamide [1508-75-4]; Up 200; 14uM; HL60; HT_HG-U133A

ZNF787 TECTA WIZ DNAJA4 LRP1 EHMT1 SYP HMGXB3

1.01e-0419916482347_UP
DrugMeprylcaine hydrochloride [956-03-6]; Up 200; 14.8uM; MCF7; HT_HG-U133A

ERBB4 RNF19B LAMC2 ADAM12 OVOL1 LRP1 MUC5AC ZNF415

1.01e-0419916483544_UP
DrugThyroxine (L) [51-48-9]; Down 200; 5.2uM; MCF7; HT_HG-U133A

RNF19B GAS6 OVOL1 WIZ LRP3 AKAP13 HMGXB3 GARRE1

1.01e-0419916483249_DN
DrugClindamycin hydrochloride [21462-39-5]; Down 200; 8.6uM; PC3; HT_HG-U133A

ZNF473 GRK6 DIDO1 ZNF318 BCL11A IL17RA ZNF415 NOTCH3

1.01e-0419916482057_DN
Drughydroxystilbamidine

HTR2C ADAMTS1 TECTA GDNF GFRA1 SYP

1.02e-041031646CID005353676
DrugSulfinpyrazone [57-96-5]; Down 200; 9.8uM; HL60; HG-U133A

WRN BCL11A ZNF467 IGF1R WIZ LRP3 AKAP13 NOTCH1

1.04e-0420016481574_DN
DrugLiothyronine [6893-02-3]; Up 200; 6.2uM; HL60; HT_HG-U133A

GAS6 GFRA1 STAB1 NRXN3 WIZ ASPH LRP2 ADGRE1

1.04e-0420016482984_UP
DiseaseMalignant neoplasm of breast

ERBB4 ANK2 ADAMTS1 DLL4 NSD2 DTX3 SHMT1 ZNF318 BCL11A TECTA ADAM12 LEPR JAG2 SETD2 IGF1R SEMA5B ARFGAP3 EHMT1 KLHDC7A ALK NOTCH1 NOTCH2 NOTCH3 PADI3 SORL1

8.41e-10107416025C0006142
DiseaseSchizophrenia

ERBB4 HTR2C GRK6 MBNL1 SHMT1 BCL11A GRM2 ADAM12 GDNF GFRA1 GFRA3 ADAMTS12 JAG2 NRXN3 NRXN1 NRXN2 UNC5C ERVK-8 LRP1 LRP2 SYP ALK

2.82e-0988316022C0036341
DiseaseGlioblastoma

GDNF JAG2 LTBP4 RECK NOTCH1 NOTCH2 NOTCH3

2.52e-07791607C0017636
DiseaseBreast Carcinoma

ERBB4 ADAMTS1 DLL4 NSD2 DTX3 SHMT1 LEPR JAG2 SETD2 IGF1R KLHDC7A ALK NOTCH1 NOTCH2 NOTCH3

2.68e-0753816015C0678222
DiseaseGiant Cell Glioblastoma

GDNF JAG2 LTBP4 RECK NOTCH1 NOTCH2 NOTCH3

3.86e-07841607C0334588
DiseaseMammary Carcinoma, Human

ADAMTS1 DLL4 NSD2 DTX3 SHMT1 LEPR JAG2 SETD2 IGF1R KLHDC7A ALK NOTCH1 NOTCH2 NOTCH3

1.15e-0652516014C4704874
DiseaseMammary Neoplasms, Human

ADAMTS1 DLL4 NSD2 DTX3 SHMT1 LEPR JAG2 SETD2 IGF1R KLHDC7A ALK NOTCH1 NOTCH2 NOTCH3

1.15e-0652516014C1257931
DiseaseMammary Neoplasms

ADAMTS1 DLL4 NSD2 DTX3 SHMT1 LEPR JAG2 SETD2 IGF1R KLHDC7A ALK NOTCH1 NOTCH2 NOTCH3

1.21e-0652716014C1458155
DiseaseGlioblastoma Multiforme

GDNF JAG2 LTBP4 RECK NOTCH1 NOTCH2 NOTCH3

2.56e-061111607C1621958
Diseaseadenocarcinoma (implicated_via_orthology)

NOTCH1 NOTCH2 NOTCH3

5.39e-0671603DOID:299 (implicated_via_orthology)
Diseasecentral nervous system cancer (implicated_via_orthology)

NOTCH1 NOTCH2 NOTCH3

5.39e-0671603DOID:3620 (implicated_via_orthology)
DiseaseMalignant neoplasm of skin

ERBB4 IGF1R NOTCH1 NOTCH2 NOTCH3

1.74e-05591605C0007114
DiseaseSkin Neoplasms

ERBB4 IGF1R NOTCH1 NOTCH2 NOTCH3

1.74e-05591605C0037286
Diseasepeak expiratory flow

ADAM19 EML4 PLCXD2 ITGA1 EYS IGF1R FIG4 LRP1 SYP LRP5 LTBP4 SORL1

1.89e-0549816012EFO_0009718
DiseaseNon-Small Cell Lung Carcinoma

ADAMTS1 EML4 LAMC2 SYP ALK RECK NOTCH3

2.39e-051561607C0007131
Diseaseintestinal cancer (implicated_via_orthology)

ERBB4 NOTCH1 NOTCH2 NOTCH3

2.66e-05321604DOID:10155 (implicated_via_orthology)
Diseaselung large cell carcinoma (biomarker_via_orthology)

DLL4 NOTCH1

2.92e-0521602DOID:4556 (biomarker_via_orthology)
Diseaselung small cell carcinoma (biomarker_via_orthology)

DLL4 NOTCH1

2.92e-0521602DOID:5409 (biomarker_via_orthology)
DiseaseIntellectual Disability

NSD2 NSD1 BCL11A PRRT2 CHAMP1 SETD2 NRXN1 NRXN2 LRP2 TAF6 TET3

3.51e-0544716011C3714756
Diseasehair color

SP2 LINC00322 SPIRE2 MBNL1 DCT ADAMTS12 VPS9D1 OVOL1 PADI3

5.36e-053111609EFO_0003924
DiseaseImpaired cognition

CR1 NOTCH3 SORL1

5.45e-05141603C0338656
DiseaseLymphoma

CSF3R TNFAIP3 NOTCH1 NOTCH2

6.54e-05401604C0024299
Diseasecystatin C measurement

TRAF1 ERBB4 SPIRE2 GRK6 NSD1 IGF1R OVOL1 CST5 LRP1 LRP2

7.32e-0540216010EFO_0004617
DiseaseSotos syndrome 1 (implicated_via_orthology)

NSD2 NSD1

8.73e-0531602DOID:0112103 (implicated_via_orthology)
DiseaseAutism Spectrum Disorders

DIPK2B NRXN3 NRXN1 NRXN2 TET3

1.02e-04851605C1510586
Diseasehair colour measurement

TRAF1 SPIRE2 ADAMTS1 MBNL1 DCT ADAMTS12 VPS9D1 OVOL1 LRP1 LRP5 AKAP13 PADI3

1.42e-0461516012EFO_0007822
DiseaseFetal Growth Retardation

NSD2 DLK1 IGF1R

1.67e-04201603C0015934
DiseaseSquamous cell carcinoma of esophagus

FAT3 DIDO1 NOTCH1 NOTCH2 NOTCH3

1.72e-04951605C0279626
Diseaselung adenocarcinoma (biomarker_via_orthology)

DLL4 NOTCH1

1.74e-0441602DOID:3910 (biomarker_via_orthology)
Diseasesuperoxide dismutase [Mn]; mitochondrial measurement

GRK6 NSD1

1.74e-0441602EFO_0021981
DiseaseSotos' syndrome

NSD1 SETD2

1.74e-0441602C0175695
DiseaseAdenoid Cystic Carcinoma

GAS6 NSD1 BCL11A SETD2 NOTCH1

2.19e-041001605C0010606
DiseaseAlzheimer's Disease

ADAMTS1 CR1 IGF1R UNC5C SORL1

2.29e-041011605C0002395
DiseaseAlzheimer's disease (implicated_via_orthology)

ANK2 IGF1R DNAJA4 LRP1

2.63e-04571604DOID:10652 (implicated_via_orthology)
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

HTR2C BCL11A LEPR IGF1R PAX4

2.75e-041051605DOID:9352 (implicated_via_orthology)
DiseaseAlzheimer's disease (biomarker_via_orthology)

IGF1R LRP1 SYP ADAM17

2.81e-04581604DOID:10652 (biomarker_via_orthology)
Diseasepolyarteritis nodosa (is_marker_for)

GDNF GFRA1

2.89e-0451602DOID:9810 (is_marker_for)
DiseaseChurg-Strauss syndrome (is_marker_for)

GDNF GFRA1

2.89e-0451602DOID:3049 (is_marker_for)
DiseaseCarcinoma, Pancreatic Ductal

JAG2 NOTCH1 NOTCH3

2.91e-04241603C0887833
Diseasebrain cancer (implicated_via_orthology)

NOTCH1 NOTCH2 NOTCH3

3.71e-04261603DOID:1319 (implicated_via_orthology)
DiseaseFEV/FEC ratio

ADAM19 ADAMTS1 EML4 NSD1 LAMC2 BCL11A ITGA1 ADAM12 FCGBP SYTL4 WNT16 LRP1 SCUBE3 LTBP3 KIF13A LTBP4 SORL1

3.83e-04122816017EFO_0004713
Diseaseurate measurement

DNAH3 ERBB4 NSD1 ZNF318 STAB1 IGF1R OVOL1 MALRD1 NRXN1 NRXN2 LRP1 LRP2 AKAP13 NOTCH2

3.89e-0489516014EFO_0004531
DiseaseAdams Oliver syndrome

DLL4 NOTCH1

4.32e-0461602C0265268
Diseaseresponse to diuretic, diastolic blood pressure change measurement

DLK1 DNAAF10

4.32e-0461602EFO_0006945, GO_0036270
DiseaseCongenital defect of skull and scalp

DLL4 NOTCH1

4.32e-0461602C2931779
DiseaseAdams-Oliver syndrome 1

DLL4 NOTCH1

4.32e-0461602C4551482
DiseaseAdams-Oliver syndrome (is_implicated_in)

DLL4 NOTCH1

4.32e-0461602DOID:0060227 (is_implicated_in)
DiseaseColorectal Carcinoma

DNAH3 ADAM19 ANK2 WRN ADAM29 TRIM28 WNT16 LRP1 LRP2 OLFM2 SLC33A1 SORL1

4.70e-0470216012C0009402
DiseaseMental Retardation, X-Linked

DIPK2B SYP ZMYM3

5.15e-04291603C1136249
Diseasecolorectal cancer, overall survival

ERBB4 ADAM19 SORL1

5.15e-04291603EFO_0000638, MONDO_0005575
Diseaseuric acid measurement

DNAH3 ERBB4 FAT3 ZNF318 GJB1 IGF1R OVOL1 NRXN2 LRP2 AKAP13 ZMYM3

5.22e-0461016011EFO_0004761
Diseasecolorectal cancer (implicated_via_orthology)

NOTCH1 NOTCH2 NOTCH3

5.70e-04301603DOID:9256 (implicated_via_orthology)
DiseaseStage IV Skin Melanoma

ADAM29 ADAM12

6.03e-0471602C1321872
Diseaseosteoporosis (is_implicated_in)

LEPR IGF1R LRP5

6.29e-04311603DOID:11476 (is_implicated_in)
DiseaseSarcomatoid Renal Cell Carcinoma

SETD2 GJB1 UNC5C AKAP13 ALK

6.81e-041281605C1266043
DiseaseChromophobe Renal Cell Carcinoma

SETD2 GJB1 UNC5C AKAP13 ALK

6.81e-041281605C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

SETD2 GJB1 UNC5C AKAP13 ALK

6.81e-041281605C1266044
DiseasePapillary Renal Cell Carcinoma

SETD2 GJB1 UNC5C AKAP13 ALK

6.81e-041281605C1306837
DiseaseRenal Cell Carcinoma

SETD2 GJB1 UNC5C AKAP13 ALK

6.81e-041281605C0007134
DiseaseSquamous cell carcinoma of lung

ERBB4 IGF1R NOTCH1

6.91e-04321603C0149782
Diseasealcohol use disorder (implicated_via_orthology)

ERBB4 GRK6 SHMT1 NOTCH1 NOTCH2 NOTCH3

7.04e-041951606DOID:1574 (implicated_via_orthology)
Diseaseesophagus squamous cell carcinoma (is_marker_for)

ERBB4 EHMT1 TNFAIP3 TET3

7.13e-04741604DOID:3748 (is_marker_for)
DiseaseTinnitus

GRK6 ADAM29 ZNF318 JAG2 TNKS

7.31e-041301605HP_0000360
Diseaseinternet addiction disorder

ERBB4 GFRA3 NRXN1

7.58e-04331603EFO_0803368
Diseaseeosinophil percentage of leukocytes

TRAF1 ADAM19 LEPR SETD2 RESF1 CSF3R AKAP13 IL17RA TNFAIP3 MUC5AC TET3 NOTCH2

7.99e-0474616012EFO_0007991
Diseaseclear cell renal cell carcinoma (is_implicated_in)

SETD2 IGF1R

8.01e-0481602DOID:4467 (is_implicated_in)
Diseasegestational age

ERBB4 EYS MALRD1 TET3 ALK

9.56e-041381605EFO_0005112
DiseaseNeoplastic Cell Transformation

NSD2 IGF1R TNFAIP3 ALK NOTCH1

9.87e-041391605C0007621
Diseasehemangiopericytoma (is_marker_for)

DLL4 NOTCH1

1.03e-0391602DOID:264 (is_marker_for)
DiseaseMental deterioration

CR1 SORL1

1.03e-0391602C0234985
DiseaseMild cognitive disorder

CR1 SORL1

1.03e-0391602C1270972
Diseaseunderweight body mass index status

ANK2 NRXN3

1.03e-0391602EFO_0005936
Diseasefree androgen index

MBNL1 ZNF318 GDNF LEPR SETD2 OVOL1 SYTL4 LRP5

1.04e-033741608EFO_0007005
Diseaselate-onset Alzheimers disease

ADAMTS1 FAT3 TECTA ZNRF4 CR1 ADAM17 SORL1

1.11e-032921607EFO_1001870
Diseaseneuroblastoma (is_implicated_in)

NSD1 IGF1R

1.28e-03101602DOID:769 (is_implicated_in)
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

SETD2 GJB1 UNC5C AKAP13 ALK

1.31e-031481605C0279702
DiseaseNeoplasm of uncertain or unknown behavior of breast

ERBB4 NOTCH1 NOTCH2

1.43e-03411603C0496956
DiseaseBreast adenocarcinoma

ERBB4 NOTCH1 NOTCH2

1.43e-03411603C0858252
Diseaseautism spectrum disorder (implicated_via_orthology)

HTR2C LAMC2 NRXN3 NRXN1 NRXN2

1.47e-031521605DOID:0060041 (implicated_via_orthology)
DiseaseSemantic-Pragmatic Disorder

BCL11A NRXN1

1.56e-03111602C0454655
DiseaseAuditory Processing Disorder, Central

BCL11A NRXN1

1.56e-03111602C0751257
DiseaseLanguage Delay

BCL11A NRXN1

1.56e-03111602C0023012
DiseaseLanguage Development Disorders

BCL11A NRXN1

1.56e-03111602C0023014
Diseaseatopic dermatitis (implicated_via_orthology)

WASL ADAM17

1.56e-03111602DOID:3310 (implicated_via_orthology)
DiseaseSpeech Delay

BCL11A NRXN1

1.56e-03111602C0241210
DiseaseCraniofacial Abnormalities

JAG2 NRXN1 LRP2 LTBP3 NOTCH1

1.65e-031561605C0376634
Diseasetransient cerebral ischemia (biomarker_via_orthology)

ANK2 ADAMTS1 DLL4 NRXN1 NOTCH1

1.69e-031571605DOID:224 (biomarker_via_orthology)
DiseaseAmelogenesis Imperfecta

LAMC2 LTBP3

1.86e-03121602C0002452
Diseaseretinopathy of prematurity (biomarker_via_orthology)

DLL4 NOTCH1

1.86e-03121602DOID:13025 (biomarker_via_orthology)
DiseaseHirschsprung's disease (implicated_via_orthology)

GDNF GFRA1

1.86e-03121602DOID:10487 (implicated_via_orthology)
Diseasesusceptibility to pneumonia measurement

ITGA1 MALRD1 UNC5C MUC5AC

1.95e-03971604EFO_0008410
Diseasesciatic neuropathy (biomarker_via_orthology)

GDNF GFRA1 GFRA3 LRP1

2.10e-03991604DOID:11446 (biomarker_via_orthology)
Diseasepulmonary function measurement, smoking behaviour measurement, FEV/FEC ratio

ADAM19 ITGA1 LRP1

2.13e-03471603EFO_0003892, EFO_0004713, EFO_0005671
Diseasemitochondrial DNA measurement

SHMT1 DLK1 ZNRF4 LDLR LEPR CSF3R SYTL4

2.16e-033281607EFO_0006312
DiseaseFamilial Alzheimer Disease (FAD)

ADAMTS1 CR1 IGF1R SORL1

2.18e-031001604C0276496
Diseasehomostachydrine measurement

ERBB4 EYS

2.19e-03131602EFO_0021164
DiseaseMigraine Disorders

LRP1 NOTCH3

2.19e-03131602C0149931
DiseaseGranulomatosis with Polyangiitis

MS4A10 TENM3

2.19e-03131602EFO_0005297
Diseasecoronary artery disease

NPC1 ZNF787 ERBB4 ADAM19 THSD7A ITGA1 LDLR ZNF77 MALRD1 NRXN1 UNC5C LRP1 AKAP13 TNKS ALK

2.20e-03119416015EFO_0001645
Diseaseserum IgG glycosylation measurement

STAB2 THSD7A WRN GFRA1 EYS OVOL1 TENM3 WFDC12 RECK

2.30e-035231609EFO_0005193

Protein segments in the cluster

PeptideGeneStartEntry
VKECVGASNQNCRTP

SLC33A1

476

O00400
QSCTCRAAEAAPVVK

AHRR

646

A9YTQ3
LNSNCSPAFCNKRGI

ADAM29

621

Q9UKF5
QSPDLESSKCLTQGC

LINC00479

51

Q96M42
IFDDSCCNGTLRKPV

ERBB4

1101

Q15303
RGCCRDPNAQSSFSK

CCDC187

411

A0A096LP49
LRSVPTNKVCFDCGA

ARFGAP3

16

Q9NP61
DTRQRKCPKCNAAFG

RNF20

951

Q5VTR2
DECQQNPRLCKSYGT

ADGRE2

121

Q9UHX3
EQARQCDLPEFCTGK

ADAM19

476

Q9H013
PASRCSEPCLQNEVK

GRM2

496

Q14416
CCKRNTAEEENSANP

HTR2C

266

P28335
DQDSCLQSLPDCGVK

AKAP13

396

Q12802
GSNCEKKVDRCTSNP

DLL4

396

Q9NR61
EDCQLKPAGTACRDS

ADAM12

471

O43184
RPACLVNGQSVKSCS

ANGPTL5

311

Q86XS5
RNENACKGAPKTCTL

ASPH

636

Q12797
ERINPKDRCESCSGA

DNAJA4

186

Q8WW22
LVGKPSDCTLASAQC

DHX30

991

Q7L2E3
PCANNRTCVSLDDGL

DLK1

96

P80370
GCQAQLPSCESISEK

DIPK2B

341

Q9H7Y0
TRKDICAGFNRPCET

ADAMTS12

346

P58397
TFSECLNLINEGCPK

CKAP2

426

Q8WWK9
SAQAPDGKCICTAVI

OLFM2

36

O95897
CLDSAGPRLNVCDKS

NSD1

1226

Q96L73
TADLSEIPRCNCKAT

NSD1

1886

Q96L73
ANELCEVNRKGCPSG

RECK

501

O95980
RSCNLEDCPDNNGKT

ADAMTS1

606

Q9UHI8
CRDINGQPASECAKE

ADAMTS1

881

Q9UHI8
PNCKRTVCLETGSQN

SLC10A4

326

Q96EP9
PKRQDDCTGSCSVAL

ANK2

2321

Q01484
IDIDECASNPCRKGA

NOTCH2

681

Q04721
PGLNCTVKNSTCLDD

IL17RA

46

Q96F46
LPECQEDAGNKVCSL

NOTCH1

1451

P46531
LSPPCDCRKEEAANQ

IGDCC3

621

Q8IVU1
PCKNNGTCVDLTNRF

EYS

936

Q5T1H1
KEAAICRCSQPLSGF

MTMR6

196

Q9Y217
CDGLRCGDNTKAAVI

GPD1L

216

Q8N335
CKSSNPEQDVCSAFR

SPINK5

151

Q9NQ38
QLDANECEGKPCLNA

JAG2

421

Q9Y219
TPGSRQCACAEDQVL

LRP1

821

Q07954
SSTQFKCNSGRCIPE

LRP1

1016

Q07954
NDLSRGACPAAEIKC

FANCM

196

Q8IYD8
IKQQCDSFPDCIDGS

LRP5

1351

O75197
DCLSTSSRGICPKQE

BCL11A

111

Q9H165
PDKRGLCVCSSFDQT

DNAAF10

331

Q96MX6
ICPSCGVNLAKDRTE

HMGXB3

641

Q12766
PSTCGKRACTENNEC

IGF1R

216

P08069
KLSPENVAAACEDGC

PDE6B

26

P35913
CPQGNNESCTDVAKE

FAM205A

841

Q6ZU69
ANGKTPSCEVNRECS

NSD2

31

O96028
DCPSAKNDDACLVPN

MS4A10

196

Q96PG2
GVAPFCSRETLKQCA

NRXN2

681

Q9P2S2
CIRINCNSSKGPETL

NRXN3

751

Q9Y4C0
DVNECLSGPCRNQAT

NOTCH3

431

Q9UM47
RCNNQKSCPDGADEK

LRP3

436

O75074
DRNCSLCADNIEGKT

LEPR

96

P48357
SDKVGQACCRPIAFD

GDNF

171

P39905
TSDEKNCPDRTCQSG

LRP2

2811

P98164
PSDKNCQSCLCTERG

MUC5AC

1251

P98088
NLDCIRINCNSSKGP

NRXN1

781

Q9ULB1
GCKLTICPQAENRND

PADI3

331

Q9ULW8
NSGICRASCKKNEQP

DEFB119

31

Q8N690
NSCTTENKNEPCGAR

ITGA1

556

P56199
EDCANGCAPTKGAVL

FOXD4

371

Q12950
DSPSGDLFTCRVCQK

OVOL1

111

O14753
SCERNCRPVNASKDI

PKD1L2

666

Q7Z442
QLCAEGLCTQDKTPS

PAX4

106

O43316
KPQSSCCRVDNITDQ

NPC1

951

O15118
RKLCSADEFPCTSGQ

MALRD1

431

Q5VYJ5
KANCSPEDPCQETVS

PRRT2

96

Q7Z6L0
ISSKDICQDRAGNCP

FRG2C

101

A6NGY1
DAPGSCLIDCNENTR

ERVK-10

106

P87889
DAPGSCLIDCNENTR

ERVK-8

106

P62685
ESTCPICLGEIQNAK

DTX3

161

Q8N9I9
PRCAVKSCDDFLGQL

CR1

1251

P17927
PAVIKNVSSACEGLC

DNAH3

2871

Q8TD57
NCQPESRSVSSCLKE

GFRA1

266

P56159
QARRKCQADPTCSAA

GFRA3

46

O60609
CDRKSCGNRNETPSD

EBF4

166

Q9BQW3
CECPEAAKQSATNGV

LINC00322

196

Q6ZN03
IANSCKAVSVLGCPD

PDSS1

271

Q5T2R2
RDKQSCPAGERCSVQ

FCGBP

836

Q9Y6R7
QQPCSRCSDGVIKLT

FIG4

836

Q92562
GQSLLKCPRCNFESN

CHAMP1

761

Q96JM3
TPNPCDRKGTQACQD

GAS6

121

Q14393
PKAIEASLQGCCSEA

GARRE1

306

O15063
PCVQGKKTRSRECNN

C7

511

P10643
CGPSLDVCAQDERSK

C7

721

P10643
AVSPCRSDCDSIRKN

FAT3

4291

Q8TDW7
GRTTCTKSQPNLDNC

CST5

91

P28325
LNCKICTGQVPSAED

DIDO1

851

Q9BTC0
QVSQSKPCERTGSCF

ATRNL1

56

Q5VV63
DEKSSFICNTLQPGC

GJB1

46

P08034
CPRTTQQSPEDCDFK

CAMP

86

P49913
NCQTQGDSILDCVPK

CSF3R

166

Q99062
QRCPTDGTAAFKEIC

LTBP3

441

Q9NS15
GRKCQDIDECSQDPS

LTBP3

861

Q9NS15
EFQRGTCSRPDTECK

MBNL1

21

Q9NR56
RDQVCKSGVCVNTAP

LTBP4

1261

Q8N2S1
SKRAEAPQGCSCENP

KLHDC7A

86

Q5VTJ3
AGCTQDQRLLDSKCD

LAMC2

126

Q13753
PNGCKLIRNRSDCKD

EML4

751

Q9HC35
VTNCTQRLEQGPCKD

GRK6

126

P43250
ACECRPGFELTKNQR

SCUBE3

181

Q8IX30
ARGEPQQDCCVKTEL

EHMT1

11

Q9H9B1
DCIVTALRSGNKECP

RING1

71

Q06587
CAVFGLPSQDACQKA

OR52H1

231

Q8NGJ2
SIACNKNTCPGDRSA

SHMT1

381

P34896
PKENARSCVNGTLVC

KIF13A

506

Q9H1H9
RKNCSLGALDQACVP

PLEKHM1

486

Q9Y4G2
CQESLGRLSPKTNTC

SYTL4

66

Q96C24
PVCRQTGNTCKELRD

SYP

181

P08247
CVGSCEAKRAEALQS

TAF6

231

P49848
QQCCLTLRTEGKEPD

DROSHA

1266

Q9NRR4
LPKANNSRSCRCPED

SORL1

1031

Q92673
ASCPKLTCEREGCQT

RNF19B

221

Q6ZMZ0
GRSCPNAVEKEPCNL

THSD7A

1201

Q9UPZ6
VLGNKPATRQDCCQS

NKPD1

96

Q17RQ9
CGEEKECSNPSNLLE

RIMOC1

51

A6NDU8
QCSPLDTNSCKQGER

RESF1

1206

Q9HCM1
LNKSQLDDCPRDSGC

SAMSN1

326

Q9NSI8
QGKGEAACQELLRCA

NOL3

66

O60936
ARLQCPKCVFGTNSS

WIZ

351

O95785
SGLQPSCDVNKRRCF

WRN

1361

Q14191
SCDVNKRRCFPGSEE

WRN

1366

Q14191
QNNLEECLQSCRKPG

STARD9

1626

Q9P2P6
SCKVQLLGSQESECP

PPP1R15B

606

Q5SWA1
PGNSEVSLVCEKLCN

RO60

296

P10155
NTPSQIDSSCCIGKE

SMCR8

576

Q8TEV9
CAQGEDESQMCRKLP

ALK

461

Q9UM73
VRCKDIDECSQSPQP

ADGRE1

76

Q14246
CTLKEGVQCSDRNSP

ADAM17

506

P78536
AICPACNSTLSGKLD

CCNB1IP1

46

Q9NPC3
PRQCKSDEECALRNG

TECTA

1461

O75443
EEPRKPNCQGSCKSQ

SPATA31A3

1086

Q5VYP0
CPECGKAFSRSSNLI

ZFP92

266

A6NM28
AGVCPADNVRCFKSD

WFDC12

31

Q8WWY7
VEKPCNCQDSRTASV

ZNF77

186

Q15935
CNAGKSCPRADVTLE

ZSCAN10

81

Q96SZ4
LDPGKCQACLQDVTR

TNFAIP3

516

P21580
VCSGTNPRKCQDLGD

SPEM3

11

A0A1B0GUW6
SIPCNNRTFKCGNDI

TMPRSS7

556

Q7RTY8
QEAFGNKLCPACSVE

PLCXD2

181

Q0VAA5
TCPNCKDGEKRSGEQ

SP2

506

Q02086
SLPCILNACSGDAKS

SPIRE2

371

Q8WWL2
KLCTPENINCRDTQG

TNKS

821

O95271
RSCPVCKQSVAATED

ZNRF4

346

Q8WWF5
DTDECLGTPCQQRCK

VWCE

181

Q96DN2
APECKVLTAAGNSCR

THOC6

311

Q86W42
DQICPKCRGEDLQSI

TRAF1

51

Q13077
CTQGFQLQDTPRKSC

STAB1

1281

Q9NY15
PRKCDPNANCVQDSA

STAB1

1421

Q9NY15
RTCELLDPCSKNNGG

STAB1

1536

Q9NY15
RDCSEINNCLLPSAG

STAB2

906

Q8WWQ8
VAGIPSECDCKNDAN

TENM3

1441

Q9P273
GCANLPLNSRQKELC

WNT16

46

Q9UBV4
PGAACSQNTNKTCEE

PTTG1IP

36

P53801
KSREERFCNENTPCP

SEMA5B

706

Q9P283
NDDRTCACQGKDPNT

TET3

961

O43151
VNKECCPRLGAESAN

DCT

36

P40126
TSENEAIKRCCSPPN

SETD2

521

Q9BYW2
PECGKCFSQRSNLIA

ZNF205

451

O95201
CNECGKSFSVRPNLT

ZNF415

546

Q09FC8
ECNDCGKPFSRVSNL

ZNF16

406

P17020
CSGVACLVKDNPQRS

WASL

61

O00401
EGLNTAASKDRCLAC

VPS9D1

431

Q9Y2B5
DPADQSVQCVPKATC

PRSS50

51

Q9UI38
DCDGLVLQSKNCTDG

UNC5C

351

O95185
QKVCEENSVSPIGCN

ZNF318

2041

Q5VUA4
GDPADATRCSICQKT

ZMYM3

401

Q14202
AEAPCRGQACSAQKA

ZNF467

66

Q7Z7K2
LDDSATICRVCQKPG

TRIM28

621

Q13263
PLVCNECGKTFRQSS

ZNF473

701

Q8WTR7
ERPNACADCGKTFSQ

ZNF787

91

Q6DD87
NPDVVCQRTCTGEKA

ZNF266

141

Q14584
EQGCPPKTCSQDEFR

LDLR

101

P01130