Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN1A SCN2A SCN3A SCN10A	3.34e-06	26	80	4	GO:0005248
GeneOntologyMolecularFunction	monoatomic ion channel activity	PTK2B SCN1A SCN2A SCN3A SCN10A KCNAB1 CATSPER3 TMC4 SLC26A6 ANO8	1.46e-05	459	80	10	GO:0005216
GeneOntologyMolecularFunction	sodium ion binding	SCN1A SCN2A SCN3A	2.18e-05	14	80	3	GO:0031402
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	SCN1A SCN2A SCN10A	4.04e-05	17	80	3	GO:0099508
GeneOntologyMolecularFunction	channel activity	PTK2B SCN1A SCN2A SCN3A SCN10A KCNAB1 CATSPER3 TMC4 SLC26A6 ANO8	4.58e-05	525	80	10	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	PTK2B SCN1A SCN2A SCN3A SCN10A KCNAB1 CATSPER3 TMC4 SLC26A6 ANO8	4.66e-05	526	80	10	GO:0022803
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNHD1 DYNC1H1 DNAH14	4.84e-05	18	80	3	GO:0008569
GeneOntologyMolecularFunction	sodium channel activity	SCN1A SCN2A SCN3A SCN10A	5.59e-05	52	80	4	GO:0005272
GeneOntologyMolecularFunction	gated channel activity	PTK2B SCN1A SCN2A SCN10A KCNAB1 CATSPER3 TMC4 ANO8	5.74e-05	334	80	8	GO:0022836
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	PTK2B SLC15A2 SCN1A SCN2A SCN3A SCN10A KCNAB1 SLC10A3 CATSPER3 TMC4 SLC26A6 ANO8	7.13e-05	793	80	12	GO:0015075
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	PTK2B SCN1A SCN2A SCN10A KCNAB1 CATSPER3	9.07e-05	182	80	6	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	PTK2B SCN1A SCN2A SCN10A KCNAB1 CATSPER3	9.63e-05	184	80	6	GO:0022832
GeneOntologyMolecularFunction	alkali metal ion binding	SCN1A SCN2A SCN3A	1.51e-04	26	80	3	GO:0031420
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNHD1 DYNC1H1 DNAH14	1.89e-04	28	80	3	GO:0051959
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	PTK2B SLC15A2 SCN1A SCN2A SCN3A SCN10A KCNAB1 SLC10A3 CATSPER3 SLC26A6 ANO8	2.11e-04	758	80	11	GO:0015318
GeneOntologyMolecularFunction	dynein intermediate chain binding	DNHD1 DYNC1H1 DNAH14	4.36e-04	37	80	3	GO:0045505
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SCN1A SCN2A SCN3A SCN10A SLC10A3	6.22e-04	171	80	5	GO:0015081
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	PTK2B SLC15A2 SCN1A SCN2A SCN3A SCN10A KCNAB1 SLC10A3 CATSPER3	8.92e-04	627	80	9	GO:0022890
GeneOntologyMolecularFunction	retinoic acid 4-hydroxylase activity	CYP2C8 CYP2C18	1.40e-03	14	80	2	GO:0008401
GeneOntologyMolecularFunction	transporter activity	PTK2B SLC15A2 SCN1A SCN2A SCN3A SCN10A KCNAB1 SLC10A3 CATSPER3 TMC4 PLTP SLC26A6 ANO8	1.75e-03	1289	80	13	GO:0005215
GeneOntologyMolecularFunction	transmembrane transporter activity	PTK2B SLC15A2 SCN1A SCN2A SCN3A SCN10A KCNAB1 SLC10A3 CATSPER3 TMC4 SLC26A6 ANO8	2.49e-03	1180	80	12	GO:0022857
GeneOntologyMolecularFunction	monoatomic cation channel activity	SCN1A SCN2A SCN3A SCN10A KCNAB1 CATSPER3	2.54e-03	343	80	6	GO:0005261
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SCN1A SCN2A SCN3A SCN10A KCNAB1 SLC10A3 CATSPER3	2.61e-03	465	80	7	GO:0046873
GeneOntologyMolecularFunction	microtubule motor activity	DNHD1 DYNC1H1 DNAH14	2.79e-03	70	80	3	GO:0003777
GeneOntologyMolecularFunction	peroxisome proliferator activated receptor binding	ASXL1 ASXL2	3.17e-03	21	80	2	GO:0042975
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP2C8 CYP2C18	4.13e-03	24	80	2	GO:0008392
GeneOntologyBiologicalProcess	membrane depolarization during action potential	SCN1A SCN2A SCN3A SCN10A	1.02e-05	36	78	4	GO:0086010
GeneOntologyBiologicalProcess	regulation of peroxisome proliferator activated receptor signaling pathway	ASXL1 ASXL2 ALOX15	4.08e-05	18	78	3	GO:0035358
GeneOntologyBiologicalProcess	cardiac muscle cell action potential involved in contraction	SCN1A SCN2A SCN3A SCN10A	8.94e-05	62	78	4	GO:0086002
GeneOntologyBiologicalProcess	neuronal action potential	SCN1A SCN2A SCN3A SCN10A	9.52e-05	63	78	4	GO:0019228
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN1A SCN2A SCN3A SCN10A	4.33e-07	17	79	4	GO:0001518
GeneOntologyCellularComponent	sodium channel complex	SCN1A SCN2A SCN3A SCN10A	4.18e-06	29	79	4	GO:0034706
GeneOntologyCellularComponent	centrosome	HORMAD2 FRY TGIF2 DCTN6 HIPK1 KIAA0586 DIAPH1 CCDC15 CDH23 HAUS2 DYNC1H1 ANKRD7	3.04e-05	770	79	12	GO:0005813
GeneOntologyCellularComponent	PR-DUB complex	ASXL1 ASXL2	8.42e-05	4	79	2	GO:0035517
GeneOntologyCellularComponent	monoatomic ion channel complex	PTK2B SCN1A SCN2A SCN3A SCN10A KCNAB1 CATSPER3 SLC26A6	9.05e-05	378	79	8	GO:0034702
GeneOntologyCellularComponent	microtubule organizing center	HORMAD2 FRY TGIF2 DCTN6 HIPK1 KIAA0586 DIAPH1 CCDC15 CDH23 HAUS2 DYNC1H1 ANKRD7	1.64e-04	919	79	12	GO:0005815
GeneOntologyCellularComponent	cation channel complex	SCN1A SCN2A SCN3A SCN10A KCNAB1 CATSPER3	2.65e-04	235	79	6	GO:0034703
GeneOntologyCellularComponent	microtubule associated complex	DNHD1 DCTN6 HAUS2 DYNC1H1 DNAH14	3.63e-04	161	79	5	GO:0005875
GeneOntologyCellularComponent	transmembrane transporter complex	PTK2B SCN1A SCN2A SCN3A SCN10A KCNAB1 CATSPER3 SLC26A6	8.00e-04	523	79	8	GO:1902495
GeneOntologyCellularComponent	transporter complex	PTK2B SCN1A SCN2A SCN3A SCN10A KCNAB1 CATSPER3 SLC26A6	1.11e-03	550	79	8	GO:1990351
GeneOntologyCellularComponent	dynein complex	DNHD1 DYNC1H1 DNAH14	1.12e-03	54	79	3	GO:0030286
GeneOntologyCellularComponent	dense core granule	VPS13C SCG2 BACE2	1.25e-03	56	79	3	GO:0031045
HumanPheno	Photosensitive myoclonic seizure	KCTD7 SCN1A SCN2A	5.76e-06	8	25	3	HP:0001327
HumanPheno	Cerebral visual impairment	VPS11 SCN1A SCN3A NAGA DIAPH1 ADARB1 D2HGDH	1.65e-05	179	25	7	HP:0100704
HumanPheno	Progressive truncal ataxia	KCTD7 SACS	2.31e-05	2	25	2	HP:0007221
HumanPheno	Hypoplasia of the corpus callosum	KCTD7 ASXL1 VPS11 SACS SCN2A SCN3A KIAA0586 DIAPH1 ADARB1 DYNC1H1	4.31e-05	478	25	10	HP:0002079
HumanPheno	Infection-related seizure	KCTD7 VPS11 SCN1A SCN2A SCN3A ASXL2	5.43e-05	145	25	6	HP:0032892
HumanPheno	Seizure precipitated by febrile infection	KCTD7 VPS11 SCN1A SCN2A SCN3A ASXL2	5.43e-05	145	25	6	HP:0032894
HumanPheno	Febrile seizure (within the age range of 3 months to 6 years)	KCTD7 VPS11 SCN1A SCN2A SCN3A ASXL2	5.43e-05	145	25	6	HP:0002373
HumanPheno	Visually-induced seizure	KCTD7 SCN1A SCN2A	8.12e-05	18	25	3	HP:0020216
HumanPheno	Reflex seizure	KCTD7 SCN1A SCN2A	1.51e-04	22	25	3	HP:0020207
HumanPheno	Abnormal cerebral white matter morphology	KCTD7 ASXL1 VPS11 SACS SCN1A SCN2A SCN3A KIAA0586 NAGA DIAPH1 ASXL2 ADARB1 D2HGDH DYNC1H1	2.03e-04	1114	25	14	HP:0002500
HumanPheno	Cerebral hypoplasia	KCTD7 VPS11 SACS VPS13C SCN1A SCN2A SCN3A KIAA0586 NAGA CDH23 TP53RK ADARB1	2.51e-04	844	25	12	HP:0006872
HumanPheno	Simple febrile seizure	SCN1A SCN2A SCN3A	2.83e-04	27	25	3	HP:0011171
Domain	Na_channel_asu	SCN1A SCN2A SCN3A SCN10A	5.80e-08	10	78	4	IPR001696
Domain	Na_trans_assoc	SCN1A SCN2A SCN3A SCN10A	5.80e-08	10	78	4	IPR010526
Domain	Na_trans_assoc	SCN1A SCN2A SCN3A SCN10A	5.80e-08	10	78	4	PF06512
Domain	Na_trans_cytopl	SCN1A SCN2A SCN3A	1.39e-06	6	78	3	PF11933
Domain	Na_trans_cytopl	SCN1A SCN2A SCN3A	1.39e-06	6	78	3	IPR024583
Domain	Dynein_HC_stalk	DNHD1 DYNC1H1 DNAH14	2.47e-05	14	78	3	IPR024743
Domain	MT	DNHD1 DYNC1H1 DNAH14	2.47e-05	14	78	3	PF12777
Domain	DHC_fam	DNHD1 DYNC1H1 DNAH14	3.08e-05	15	78	3	IPR026983
Domain	Dynein_heavy_dom	DNHD1 DYNC1H1 DNAH14	3.08e-05	15	78	3	IPR004273
Domain	Dynein_heavy	DNHD1 DYNC1H1 DNAH14	3.08e-05	15	78	3	PF03028
Domain	HARE-HTH	ASXL1 ASXL2	5.15e-05	3	78	2	PF05066
Domain	ASXH	ASXL1 ASXL2	5.15e-05	3	78	2	PF13919
Domain	PHD_3	ASXL1 ASXL2	5.15e-05	3	78	2	PF13922
Domain	ASX-like_PHD	ASXL1 ASXL2	5.15e-05	3	78	2	IPR026905
Domain	ASX/ASX-like	ASXL1 ASXL2	5.15e-05	3	78	2	IPR024811
Domain	ASXH	ASXL1 ASXL2	5.15e-05	3	78	2	IPR028020
Domain	HB1/Asxl_HTH	ASXL1 ASXL2	5.15e-05	3	78	2	IPR007759
Domain	Channel_four-helix_dom	SCN1A SCN2A SCN3A SCN10A	9.40e-05	57	78	4	IPR027359
Domain	-	SCN1A SCN2A SCN3A SCN10A	9.40e-05	57	78	4	1.20.120.350
Domain	Ion_trans_dom	SCN1A SCN2A SCN3A SCN10A CATSPER3	1.15e-04	114	78	5	IPR005821
Domain	Ion_trans	SCN1A SCN2A SCN3A SCN10A CATSPER3	1.15e-04	114	78	5	PF00520
Domain	IQ_motif_EF-hand-BS	SCN1A SCN2A SCN3A SCN10A	5.48e-04	90	78	4	IPR000048
Domain	BPI1	BPIFB1 PLTP	6.08e-04	9	78	2	SM00328
Domain	IQ	SCN1A SCN2A SCN3A SCN10A	6.20e-04	93	78	4	PS50096
Domain	LBP_BPI_CETP_C	BPIFB1 PLTP	7.58e-04	10	78	2	PF02886
Domain	Lipid-bd_serum_glycop_C	BPIFB1 PLTP	1.11e-03	12	78	2	IPR001124
Domain	LBP_BPI_CETP	BPIFB1 PLTP	1.30e-03	13	78	2	PF01273
Domain	BPI/LBP/Plunc	BPIFB1 PLTP	1.30e-03	13	78	2	IPR032942
Domain	Bactericidal_perm-incr_a/b_dom	BPIFB1 PLTP	1.30e-03	13	78	2	IPR017943
Domain	Lipid-bd_serum_glycop_N	BPIFB1 PLTP	1.30e-03	13	78	2	IPR017942
Domain	Dynein_heavy_chain_D4_dom	DYNC1H1 DNAH14	1.52e-03	14	78	2	IPR024317
Domain	Dynein_heavy_dom-2	DNHD1 DYNC1H1	1.52e-03	14	78	2	IPR013602
Domain	DHC_N2	DNHD1 DYNC1H1	1.52e-03	14	78	2	PF08393
Domain	AAA_8	DYNC1H1 DNAH14	1.52e-03	14	78	2	PF12780
Domain	Neurexin-like	CADM1 NRXN3	1.52e-03	14	78	2	IPR003585
Domain	4.1m	CADM1 NRXN3	1.52e-03	14	78	2	SM00294
Domain	IQ	SCN1A SCN3A SCN10A	3.27e-03	71	78	3	PF00612
Domain	IQ	SCN1A SCN2A SCN3A	4.73e-03	81	78	3	SM00015
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SCN1A SCN2A SCN3A SCN10A	9.76e-06	31	62	4	M877
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	SCN1A SCN2A SCN3A SCN10A	1.11e-05	32	62	4	M27455
Pathway	WP_DRAVET_SYNDROME	SCN1A SCN2A SCN3A	2.45e-04	28	62	3	M45519
Pathway	REACTOME_MUSCLE_CONTRACTION	HIPK1 SCN1A SCN2A SCN3A SCN10A NEB	2.60e-04	203	62	6	M5485
Pathway	REACTOME_CARDIAC_CONDUCTION	HIPK1 SCN1A SCN2A SCN3A SCN10A	2.62e-04	130	62	5	M27454
Pathway	KEGG_LINOLEIC_ACID_METABOLISM	CYP2C8 CYP2C18 ALOX15	2.73e-04	29	62	3	M2920
Pubmed	Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.	SCN1A SCN2A SCN3A NEB	1.36e-10	5	81	4	1679748
Pubmed	A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.	SCN1A SCN2A SCN3A NEB	1.36e-10	5	81	4	8812438
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN1A SCN2A SCN3A SCN10A	4.08e-10	6	81	4	23652591
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN1A SCN2A SCN3A SCN10A	3.41e-09	9	81	4	16382098
Pubmed	Sodium channels SCN1A, SCN2A and SCN3A in familial autism.	SCN1A SCN2A SCN3A	1.22e-08	3	81	3	12610651
Pubmed	SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.	SCN1A SCN2A SCN3A	1.22e-08	3	81	3	23859570
Pubmed	Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.	SCN1A SCN2A SCN3A	1.22e-08	3	81	3	18784617
Pubmed	Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.	SCN1A SCN2A SCN3A	1.22e-08	3	81	3	17544618
Pubmed	Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.	SCN1A SCN2A SCN3A	1.22e-08	3	81	3	14973256
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN1A SCN2A SCN3A SCN10A	1.92e-08	13	81	4	15123669
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN1A SCN2A SCN3A	4.86e-08	4	81	3	17537961
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN1A SCN2A SCN3A	4.86e-08	4	81	3	35031483
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN1A SCN2A SCN3A	4.86e-08	4	81	3	29578003
Pubmed	Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.	SCN1A SCN2A SCN3A	4.86e-08	4	81	3	35801810
Pubmed	Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.	SCN1A SCN2A SCN3A	4.86e-08	4	81	3	8974318
Pubmed	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.	SCN1A SCN2A SCN3A	1.21e-07	5	81	3	24337656
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN1A SCN2A SCN3A	1.01e-06	9	81	3	15746173
Pubmed	Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment.	CYP2C8 SCN1A SCN2A	1.44e-06	10	81	3	20602612
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FRY UBA7 CADM1 SACS DCTN6 ACO1 HIPK1 SCG2 CCDC15 APEH BACE2 ADARB1 DYNC1H1 KPNB1	1.49e-06	1285	81	14	35914814
Pubmed	Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.	SCN1A SCN2A SCN3A	2.64e-06	12	81	3	8169823
Pubmed	Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.	SCN1A SCN2A SCN3A	2.64e-06	12	81	3	30175250
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	DNHD1 SLC15A2 ACO1 VPS13C CAPZB SCN10A BPIFB1 SUCNR1 NEB DYNC1H1 PGM1 KPNB1	4.01e-06	1016	81	12	19056867
Pubmed	Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.	SCN1A SCN2A	5.36e-06	2	81	2	29649454
Pubmed	Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.	SCN2A SCN3A	5.36e-06	2	81	2	20346423
Pubmed	Phospholipid transfer protein is regulated by liver X receptors in vivo.	NR1H3 PLTP	5.36e-06	2	81	2	12177004
Pubmed	Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.	SCN1A SCN2A	5.36e-06	2	81	2	10827969
Pubmed	ASXL1/2 mutations and myeloid malignancies.	ASXL1 ASXL2	5.36e-06	2	81	2	36068610
Pubmed	Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.	SCN1A SCN2A	5.36e-06	2	81	2	19694741
Pubmed	Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.	SCN2A SCN3A	5.36e-06	2	81	2	11245985
Pubmed	Differential expression of two sodium channel subtypes in human brain.	SCN1A SCN2A	5.36e-06	2	81	2	1317301
Pubmed	Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.	SCN2A SCN3A	5.36e-06	2	81	2	23016767
Pubmed	Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.	SCN2A SCN3A	5.36e-06	2	81	2	27153334
Pubmed	Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.	SCN1A SCN2A	5.36e-06	2	81	2	33096315
Pubmed	Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.	SCN1A SCN3A	5.36e-06	2	81	2	24990319
Pubmed	Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.	SCN1A SCN2A	5.36e-06	2	81	2	31439038
Pubmed	Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.	SCN1A SCN2A	5.36e-06	2	81	2	26311622
Pubmed	Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs.	CYP2C8 CYP2C18	5.36e-06	2	81	2	10487415
Pubmed	The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions.	NR1H3 PLTP	5.36e-06	2	81	2	12612088
Pubmed	Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.	SCN1A SCN2A	5.36e-06	2	81	2	15249644
Pubmed	Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.	SCN1A SCN3A	5.36e-06	2	81	2	27690330
Pubmed	ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.	ASXL1 ASXL2	5.36e-06	2	81	2	28516957
Pubmed	The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.	SCN1A SCN2A	5.36e-06	2	81	2	21377452
Pubmed	Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.	SCN1A SCN3A	5.36e-06	2	81	2	23965409
Pubmed	SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.	SCN1A SCN2A	5.36e-06	2	81	2	30693367
Pubmed	Confirmation of quantitative trait loci for alcohol preference in mice.	SCN1A SCN2A SCN3A	5.43e-06	15	81	3	9726281
Pubmed	Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation.	RANBP10 SCN3A DYNC1H1	8.08e-06	17	81	3	20395553
Pubmed	Voltage-gated sodium channels in taste bud cells.	SCN2A SCN3A	1.60e-05	3	81	2	19284629
Pubmed	Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.	SCN1A SCN2A	1.60e-05	3	81	2	28784306
Pubmed	Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.	SCN1A SCN2A	1.60e-05	3	81	2	32185219
Pubmed	Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor {gamma}.	ASXL1 ASXL2	1.60e-05	3	81	2	21047783
Pubmed	Clinical exome sequencing as the first-tier test for diagnosing developmental disorders covering both CNV and SNV: a Chinese cohort.	SCN1A SCN2A	1.60e-05	3	81	2	32005694
Pubmed	The human CYP2C locus: a prototype for intergenic and exon repetition splicing events.	CYP2C8 CYP2C18	1.60e-05	3	81	2	10704292
Pubmed	Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).	SCN1A SCN3A	1.60e-05	3	81	2	33895391
Pubmed	Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.	SCN3A SCN10A	1.60e-05	3	81	2	19699781
Pubmed	Characterization of Asxl1, a murine homolog of Additional sex combs, and analysis of the Asx-like gene family.	ASXL1 ASXL2	1.60e-05	3	81	2	16412590
Pubmed	Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.	SCN1A SCN2A	1.60e-05	3	81	2	32845893
Pubmed	Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.	SCN1A SCN2A	1.60e-05	3	81	2	28518218
Pubmed	GAPDH-mediated posttranscriptional regulations of sodium channel Scn1a and Scn3a genes under seizure and ketogenic diet conditions.	SCN1A SCN3A	1.60e-05	3	81	2	27816501
Pubmed	Gene-to-gene interaction between sodium channel-related genes in determining the risk of antiepileptic drug resistance.	SCN1A SCN2A	1.60e-05	3	81	2	19270815
Pubmed	Functional proteomics of the epigenetic regulators ASXL1, ASXL2 and ASXL3: a convergence of proteomics and epigenetics for translational medicine.	ASXL1 ASXL2	1.60e-05	3	81	2	25835095
Pubmed	Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells.	SCN2A SCN3A	1.60e-05	3	81	2	16052353
Pubmed	ASXL2 mutations are frequently found in pediatric AML patients with t(8;21)/ RUNX1-RUNX1T1 and associated with a better prognosis.	ASXL1 ASXL2	1.60e-05	3	81	2	28063196
Pubmed	Familial and Somatic BAP1 Mutations Inactivate ASXL1/2-Mediated Allosteric Regulation of BAP1 Deubiquitinase by Targeting Multiple Independent Domains.	ASXL1 ASXL2	1.60e-05	3	81	2	29284740
Pubmed	Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy.	SCN1A SCN2A	1.60e-05	3	81	2	25155934
Pubmed	Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure.	SCN10A NR1H3	1.60e-05	3	81	2	26076474
Pubmed	Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.	SCN1A SCN2A	1.60e-05	3	81	2	17928448
Pubmed	Kinetic Characterization of ASXL1/2-Mediated Allosteric Regulation of the BAP1 Deubiquitinase.	ASXL1 ASXL2	1.60e-05	3	81	2	33731362
Pubmed	Understanding the phenotypic spectrum of ASXL-related disease: Ten cases and a review of the literature.	ASXL1 ASXL2	1.60e-05	3	81	2	33751773
Pubmed	Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice.	SCN3A SCN10A	1.60e-05	3	81	2	17052333
Pubmed	AGTR1, PLTP, and SCG2 associated with immune genes and immune cell infiltration in calcific aortic valve stenosis: analysis from integrated bioinformatics and machine learning.	SCG2 PLTP	1.60e-05	3	81	2	35341274
Pubmed	Report and abstracts of the Fourth International Workshop on Human Chromosome 2 Mapping 1996.	SCN1A SCN2A SCN3A NEB	2.36e-05	71	81	4	8751373
Pubmed	Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.	DCTN6 KIAA0586 CCDC15 HAUS2 DYNC1H1	2.41e-05	146	81	5	21399614
Pubmed	Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.	CYP2C8 CYP2C18	3.20e-05	4	81	2	2009263
Pubmed	Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms.	SCN1A SCN2A	3.20e-05	4	81	2	26637798
Pubmed	Liver X Receptors Protect Dorsal Root Ganglia from Obesity-Induced Endoplasmic Reticulum Stress and Mechanical Allodynia.	SCN10A NR1H3	3.20e-05	4	81	2	30304667
Pubmed	Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a German population.	CYP2C8 CYP2C18	3.20e-05	4	81	2	21798861
Pubmed	BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion.	ASXL1 ASXL2	3.20e-05	4	81	2	34170818
Pubmed	Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.	SCN1A SCN2A	3.20e-05	4	81	2	21156207
Pubmed	Biochemistry and molecular biology of the human CYP2C subfamily.	CYP2C8 CYP2C18	3.20e-05	4	81	2	7704034
Pubmed	Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.	SCN1A SCN10A	3.20e-05	4	81	2	22260870
Pubmed	Nucleolin-Mediated RNA Localization Regulates Neuron Growth and Cycling Cell Size.	DYNC1H1 KPNB1	3.20e-05	4	81	2	27477284
Pubmed	Gene expression in distinct regions of the heart.	CYP2C8 CYP2C18	3.20e-05	4	81	2	10768437
Pubmed	Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.	CYP2C8 CYP2C18	3.20e-05	4	81	2	23755828
Pubmed	Oncogenic Truncations of ASXL1 Enhance a Motif for BRD4 ET-Domain Binding.	ASXL1 ASXL2	3.20e-05	4	81	2	34536441
Pubmed	Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.	CYP2C8 CYP2C18	3.20e-05	4	81	2	19706858
Pubmed	Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.	CYP2C8 CYP2C18 APEH	4.72e-05	30	81	3	20529763
Pubmed	Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions.	CADM1 NRXN3	5.33e-05	5	81	2	36709330
Pubmed	Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues.	CYP2C8 CYP2C18	5.33e-05	5	81	2	9797707
Pubmed	Actin-capping protein promotes microtubule stability by antagonizing the actin activity of mDia1.	CAPZB DIAPH1	5.33e-05	5	81	2	22918941
Pubmed	Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.	SCN2A SCN3A	5.33e-05	5	81	2	17724025
Pubmed	Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.	CYP2C8 CYP2C18	5.33e-05	5	81	2	11093772
Pubmed	Neuronal LXR Regulates Neuregulin 1 Expression and Sciatic Nerve-Associated Cell Signaling in Western Diet-fed Rodents.	SCN10A NR1H3	5.33e-05	5	81	2	32286429
Pubmed	Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study.	FRY NRXN3 SACS	5.75e-05	32	81	3	25189868
Pubmed	An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.	SCN3A SCN10A	7.99e-05	6	81	2	23711479
Pubmed	Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.	CADM1 SCN1A SLC10A3 NR6A1 TP53RK PGM1	8.24e-05	306	81	6	18973680
Pubmed	Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.	SCN1A SCN2A	1.12e-04	7	81	2	25818041
Pubmed	Pain without nociceptors? Nav1.7-independent pain mechanisms.	SCN3A SCN10A	1.12e-04	7	81	2	24440715
Pubmed	The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells.	DYNC1H1 KPNB1	1.12e-04	7	81	2	26195665
Pubmed	Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.	CYP2C8 CYP2C18 SCN1A DYNC1H1	1.35e-04	111	81	4	21163940
Pubmed	Significant determinants of mouse pain behaviour.	SCN3A SCN10A	1.49e-04	8	81	2	25101983
Cytoband	2q24.3	SCN1A SCN2A	3.63e-04	16	81	2	2q24.3
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN1A SCN2A SCN3A SCN10A	6.45e-09	9	50	4	1203
GeneFamily	BPI fold containing	BPIFB1 PLTP	8.77e-04	16	50	2	456
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Ciliated_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	DNHD1 ZSCAN31 CCDC15 KCNAB1 ALOX15	1.04e-05	160	80	5	6de505bfe1fbbe984718740a9cf43d0e02ff452e
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Ciliated_2\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	DNHD1 ZSCAN31 CCDC15 KCNAB1 ALOX15	1.20e-05	165	80	5	731147b4337fd0de4383dc8170b4f9ccd98caec6
ToppCell	facs-Lung-24m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l14\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RANBP10 NRXN3 ZBTB33 NEB D2HGDH	1.35e-05	169	80	5	813472d429c0b12580b17b440e00a6d8beb7947f
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-Granular_Neuron_CB_Gabra6\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN3 KASH5 SCG2 SCN1A ADARB1	1.83e-05	180	80	5	d76349ecef7c5878bf215e946f032264161eb61b
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN3 KASH5 SCG2 SCN1A ADARB1	1.83e-05	180	80	5	3d54cc767e25d91ed2203d8a03e5bf5e15f21699
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN3 SCG2 SCN1A SCN2A ADARB1	1.83e-05	180	80	5	f6a2208960d0df1500c974cc44c3c054cd7475a9
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NRXN3 CSTF2 BPIFB1 BACE2 ALOX15	1.93e-05	182	80	5	818b5155ec81f0059048d6070a108116ecd72e3c
ToppCell	Control-Epithelial_cells-Airway_mucous\|Control / group, cell type (main and fine annotations)	CYP2C18 SCN2A SCN3A BPIFB1 BACE2	1.98e-05	183	80	5	15d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN3 SCG2 SCN1A SCN2A ADARB1	2.09e-05	185	80	5	70de48988c1f8e0809afc8092b663aa439d8e528
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN3 SCG2 SCN1A SCN2A ADARB1	2.20e-05	187	80	5	7b2cd0c618ed081223343f3bec2244c8723c9a31
ToppCell	21-Trachea-Epithelial-Neuroendocrine\|Trachea / Age, Tissue, Lineage and Cell class	SCG2 SCN2A SCN3A SUCNR1 NEB	2.25e-05	188	80	5	e78d4f7a5d28c77503cb041ff585d13df4c88bd2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CADM1 SCN2A SCN3A NR6A1 BACE2	2.31e-05	189	80	5	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SCG2 SCN2A SCN3A SUCNR1 NEB	2.37e-05	190	80	5	40d8b3403f4e38436b961cd3a2e69826cbae3042
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SCG2 SCN2A SCN3A SUCNR1 NEB	2.37e-05	190	80	5	f6cbf6d292f488ada5f7581e1dceba6198b933d1
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SCG2 SCN2A SCN3A SUCNR1 NEB	2.37e-05	190	80	5	a9a705455019e28d655636de73b07540798f82e6
ToppCell	15-Trachea-Epithelial-Neuroendocrine\|Trachea / Age, Tissue, Lineage and Cell class	SCG2 SCN2A SCN3A SUCNR1 NEB	2.43e-05	191	80	5	76311fa5f3ae9bb27cf04387a8c92300f2888c28
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRY NRXN3 SCN3A KCNAB1 ADARB1	2.49e-05	192	80	5	bfab13793e54de2550ee171397f7ece0625cdb4a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRY NRXN3 SCN3A KCNAB1 ADARB1	2.49e-05	192	80	5	b54b0d5b88139905521c8d5d58332e89c08d589c
ToppCell	human_hepatoblastoma-Tumor_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	ASXL1 CADM1 NRXN3 NR6A1 DNAH14	2.55e-05	193	80	5	503a979328c68b096680b71359a26f02fafdff35
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CADM1 SLC15A2 SUCNR1 NEB BACE2	2.82e-05	197	80	5	4ea3f57cd88b8a6bb7cb4b9e3545c0fa8f331886
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	NRXN3 SCG2 SCN2A SCN3A KCNAB1	2.82e-05	197	80	5	4961f66606f08e399508fd6cabca588e7ab406a8
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FRY NRXN3 SCN1A SCN2A SCN3A	2.89e-05	198	80	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FRY NRXN3 SCN1A SCN2A SCN3A	2.89e-05	198	80	5	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FRY NRXN3 SCN1A SCN2A SCN3A	2.89e-05	198	80	5	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Deptor_(Deep_layer_pyramidal_cells--Layer_5a)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	KASH5 BPIFB1 NEB ANKRD7	4.32e-05	108	80	4	514dfc3f7ac303311ae599f981f3f3c7eb6801b8
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGIF2 MROH2A CCDC15 CDH23	1.54e-04	150	80	4	973252f4de9a1194aea9f3cb0e1f113643f16c91
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NRXN3 SLC15A2 BPIFB1 TMC4	1.62e-04	152	80	4	1b2a39ae159e79f1fb18d6d164bd7acab5299fca
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Vgll3_(Dentate_hilum?)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	WDR87 MROH2A SCN10A	1.72e-04	60	80	3	aa75fef294803ec6396c7d2c1f51d52bc4a5b43f
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Vgll3_(Dentate_hilum?)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	WDR87 MROH2A SCN10A	1.72e-04	60	80	3	069fbabfd0e48e5809ff01a026439fd0bd017779
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SCN1A SCN2A SCN3A ANKRD7	1.75e-04	155	80	4	77fdae85d36efb776db977eb424b32487ef222e4
ToppCell	facs-Marrow-T_cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CADM1 SLC15A2 DENND2C NR1H3	1.79e-04	156	80	4	5caefdc6cc86f2ac52abe8c8da821db14f476915
ToppCell	facs-Marrow-T_cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CADM1 SLC15A2 DENND2C NR1H3	1.79e-04	156	80	4	758f57dc10fc5cad200bf5b310c10ec9b1405f23
ToppCell	LPS-antiTNF-Endothelial-Epi-like-Alv_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NAGA TMC4 BACE2 ANO8	1.84e-04	157	80	4	abfd05ed993b80822739f47a735f154092a23632
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN3 DENND2C SCN10A KCNAB1	1.88e-04	158	80	4	f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN3 DENND2C SCN10A KCNAB1	1.88e-04	158	80	4	8c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NRXN3 SLC15A2 BPIFB1 BACE2	2.02e-04	161	80	4	2d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCell	390C-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	KCTD7 DNHD1 SPEF2 KIAA0586	2.07e-04	162	80	4	45be019b50e3727fc9d3fad2ff78e74e4f2d746b
ToppCell	390C-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	KCTD7 DNHD1 SPEF2 KIAA0586	2.07e-04	162	80	4	fbb0cc2b1434a340dc35058b77c73ea61004c252
ToppCell	3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2C18 BPIFB1 BACE2 ALOX15	2.12e-04	163	80	4	22fa5d017ff796394394d952ec151e2d1beb8248
ToppCell	droplet-Liver-nan-3m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGIF2 SIMC1 KIAA0586 PGM1	2.17e-04	164	80	4	950f87d9dacee45c9004a9bf894543de38f72ee5
ToppCell	droplet-Liver-nan-3m-Lymphocytic-NK/T\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGIF2 SIMC1 KIAA0586 PGM1	2.17e-04	164	80	4	c33910a6d87580902e9e7bd27afe6ea63b5eff8d
ToppCell	droplet-Liver-nan-3m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGIF2 SIMC1 KIAA0586 PGM1	2.17e-04	164	80	4	bf0d3ad9016a0b8011a2385bb92f0a4f5edad1d6
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2C8 IRAK1 BPIFB1 BACE2	2.32e-04	167	80	4	d1a13d6ada572d8ddb2da95e6e122d2b705fad7f
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	VPS11 APEH NR1H3 EDC4	2.38e-04	168	80	4	94cded2e953c0970bf2f3dbe0ce46bd77a5ed8c7
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|Myeloid_cells / Location, Cell class and cell subclass	DNHD1 CCDC15 BPIFB1 NEB	2.43e-04	169	80	4	dba8f5599aa21feef5b7fdfed2e3ab54748d80f7
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NRXN3 BPIFB1 TMC4 BACE2	2.43e-04	169	80	4	db73dae011ff3749b3706e50ab46d03b775dd6bb
ToppCell	Control-Hematopoietic_Meg-Ery\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RANBP10 HIPK1 BACE2 ALOX15	2.43e-04	169	80	4	c2e2a7b89fe4a64d79efafdec037c4104f433061
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NRXN3 BPIFB1 TMC4 BACE2	2.43e-04	169	80	4	97b7047b87ce0052d8580565c9b44fd2aa6f0d5c
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NRXN3 BPIFB1 TMC4 BACE2	2.43e-04	169	80	4	1a684471dbda42e1470e5a889648666e14f25982
ToppCell	Control-Hematopoietic_Meg-Ery-Erythroid\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RANBP10 HIPK1 BACE2 ALOX15	2.43e-04	169	80	4	df1fc1477bbbb285063b9b122b1ac84c87fd7fa8
ToppCell	Control-Hematopoietic_Meg-Ery-Erythroid-Erythroid\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RANBP10 HIPK1 BACE2 ALOX15	2.43e-04	169	80	4	92986559aa4a744e8b0487b0ae035cfb1fbf9890
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|metastatic_Lymph_Node / Location, Cell class and cell subclass	DNHD1 CCDC15 BPIFB1 NEB	2.60e-04	172	80	4	f673a2e697b46e7cfa4186cb3fb2b98e3c83703e
ToppCell	(03)_Secretory-(0)_uninjured\|(03)_Secretory / shred by cell type and Timepoint	CADM1 SLC15A2 BPIFB1 ALOX15	2.72e-04	174	80	4	ebdddb5091afcc49ab533c890f260f709880c5f9
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PTK2B SLFN13 DIAPH1 ADARB1	2.78e-04	175	80	4	a3f8c54c77bce9b035a4835945ab341909be4946
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PTK2B KASH5 BACE2 DNAH14	2.78e-04	175	80	4	c227fc5d1ccb69b82a96a6354913cafaf27d0eec
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_activate-7\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC15A2 SCN3A USP40 NEB	2.84e-04	176	80	4	dde46f06f6fc3f7ba83be91a0ee6231790955e3e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CADM1 SCN2A SCN3A BACE2	2.90e-04	177	80	4	dc846d0feb94d4c289553cc3ac9dac81d10409cb
ToppCell	nucseq-Epithelial-Epithelial_Airway-Secretory/RAS\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NRXN3 SLC15A2 BPIFB1 BACE2	2.90e-04	177	80	4	779ba86f53650772755b52460be03f18bb204e55
ToppCell	nucseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NRXN3 SLC15A2 BPIFB1 BACE2	2.90e-04	177	80	4	0f210cfb61b873c5fd77dc17eadf4d017306500e
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-9\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RANBP10 SCN3A CCDC15 BACE2	2.90e-04	177	80	4	ae55773c531099a9e94f44f01ba48b5e71dddc53
ToppCell	E16.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HSPA4L SCG2 EMC9 BPIFB1	2.96e-04	178	80	4	d3a75a8082e70543b84c35d53fe77625300d19fa
ToppCell	LPS-antiTNF-Hematopoietic_Meg-Ery-Erythroid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RANBP10 HIPK1 BACE2 ALOX15	2.96e-04	178	80	4	eafacc8cd3e986d6ca309e05b6e241331a584fa5
ToppCell	LPS-antiTNF-Hematopoietic_Meg-Ery\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RANBP10 HIPK1 BACE2 ALOX15	2.96e-04	178	80	4	6a5c31e976852edc7d9e899da8e2a1bf23d36759
ToppCell	LPS-antiTNF-Hematopoietic_Meg-Ery-Erythroid-Erythroid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RANBP10 HIPK1 BACE2 ALOX15	2.96e-04	178	80	4	370749834a11d981e9ede26d5f63f0ecb551c015
ToppCell	E16.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HSPA4L SCG2 EMC9 BPIFB1	2.96e-04	178	80	4	b2cda1df801b1a1a41e3dd2808baef37765cd804
ToppCell	Adult-Epithelial-lung_goblet_cell\|Adult / Lineage, Cell type, age group and donor	NRXN3 SLC15A2 BPIFB1 BACE2	3.03e-04	179	80	4	1fc1f252ca943a2f649d1e627f56acbf15f8e058
ToppCell	COVID-19-kidney-vSMC/Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FRY NRXN3 SCN3A KCNAB1	3.03e-04	179	80	4	111b1084f73306bdeffaaf240e7dbb4f5bf33de1
ToppCell	human_hepatoblastoma-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	FRY NRXN3 KCNAB1 CRYBG3	3.03e-04	179	80	4	14fc8ccb6b215063d747643f47d780d2b237eb67
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRY CADM1 SCN2A SCN3A	3.03e-04	179	80	4	d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCell	PCW_13-14-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SCG2 SCN1A SCN2A SCN3A	3.03e-04	179	80	4	af0b54c9ea0b6e4210f22dbb6e88ecd3276a5f86
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Sema3e\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	KASH5 BPIFB1 DNAH14	3.08e-04	73	80	3	51bcbb57ee6c45cad88cb3e2cedab2cf3503b2a5
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CADM1 NRXN3 SLC15A2 TMC4	3.16e-04	181	80	4	b45b11428d13950369347e051d4d517efb2bd4fd
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NRXN3 SLC15A2 BPIFB1 TMC4	3.22e-04	182	80	4	3f1a666fe27dd7529c114539ed5f6b8ca585c875
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN3 SCG2 SCN1A SCN2A	3.36e-04	184	80	4	7d9bcdaff8cbea4c50ab7db0f8e01f6bbd0ef593
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRY NRXN3 SCN3A KCNAB1	3.43e-04	185	80	4	51dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCell	facs-Brain_Non-Myeloid-Cerebellum\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN3 SCG2 SCN2A ADARB1	3.43e-04	185	80	4	c083a4974590b9ed3ecafedd3e9cdebc5047fe39
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRY NRXN3 SCN3A KCNAB1	3.43e-04	185	80	4	a8c02cec3c414f3a0da9f2d6d28ce563b0030705
ToppCell	LPS_only-Hematopoietic_Meg-Ery-Erythroid-Erythroid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RANBP10 HIPK1 NR6A1 ALOX15	3.50e-04	186	80	4	e5014443e9d6e25943308483e20d48b776ae5373
ToppCell	LPS_only-Hematopoietic_Meg-Ery-Erythroid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RANBP10 HIPK1 NR6A1 ALOX15	3.50e-04	186	80	4	affc246a1091e44dc85a5e237c778a7541d5a2b4
ToppCell	LPS_only-Hematopoietic_Meg-Ery\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RANBP10 HIPK1 NR6A1 ALOX15	3.50e-04	186	80	4	40d1e15402fdfb3b5ae850a2070cd4b68fda3159
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-Granular_Neuron_CB_Gabra6\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN3 SCG2 SCN2A ADARB1	3.50e-04	186	80	4	d6c8ce2a32c218dcc63d861cc247152430ed3c8c
ToppCell	10x5'-Liver-Myeloid_Dendritic-DC1\|Liver / Manually curated celltypes from each tissue	CADM1 NAGA CRYBG3 ALOX15	3.50e-04	186	80	4	e823529ffd06352c6bdec102f221fdf27f7c7369
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SLC15A2 SCN3A BACE2 ADARB1	3.57e-04	187	80	4	d01926be1c8846a25fb6706e26b56b808b69f8f0
ToppCell	Monocytes-M2-like_CD16+_macrophages\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	CADM1 KCNAB1 NEB PLTP	3.57e-04	187	80	4	59e31c51183ed4c9a3d0792c8005ea3a12b28dfa
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SCG2 SCN3A SUCNR1 NEB	3.64e-04	188	80	4	1f912ea015f50570e848259d948a0ba682d64bb4
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	FRY SCN3A KCNAB1 ADARB1	3.64e-04	188	80	4	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN3 SCG2 SCN1A ADARB1	3.64e-04	188	80	4	1efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CADM1 SCN2A SCN3A BACE2	3.64e-04	188	80	4	bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCell	COVID-19-kidney-DCT\|kidney / Disease (COVID-19 only), tissue and cell type	CADM1 SCN2A SCN3A BACE2	3.64e-04	188	80	4	df1fd0819d301679f3c9ea404e942e39095912eb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CADM1 SCN2A SCN3A BACE2	3.64e-04	188	80	4	eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	NRXN3 SCG2 SCN2A SCN3A	3.64e-04	188	80	4	b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCell	Control-Epithelial_cells\|Control / group, cell type (main and fine annotations)	CADM1 SCN1A NR6A1 DNAH14	3.64e-04	188	80	4	707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell	myeloid-macrophage\|myeloid / Lineage and Cell class	KCNAB1 NR1H3 BACE2 PLTP	3.72e-04	189	80	4	7c7dc5361250d6848c4050f8ef995561a0984a44
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTK2B SCG2 SCN3A KCNAB1	3.72e-04	189	80	4	3e8e30160a8d6f531ff743cb5918c9e79481f1bd
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	FRY SCN3A KCNAB1 ADARB1	3.72e-04	189	80	4	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CADM1 SCN2A SCN3A BACE2	3.72e-04	189	80	4	7eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTK2B SCG2 SCN3A KCNAB1	3.72e-04	189	80	4	851f8144aed5c7f80302911cd6b03f14bde7b56d
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTK2B SCG2 SCN3A KCNAB1	3.79e-04	190	80	4	1c5cf933ce71fed5638b9ef31eb81f6c2b6dadbc
ToppCell	IPF-Epithelial-Goblet\|IPF / Disease state, Lineage and Cell class	NRXN3 SLC15A2 BPIFB1 BACE2	3.79e-04	190	80	4	e41dd5a997ad9952810ffecb57737c03ea1d88b3
ToppCell	IPF-Epithelial-Goblet\|World / Disease state, Lineage and Cell class	NRXN3 SLC15A2 BPIFB1 BACE2	3.79e-04	190	80	4	c29dabf0826663b9d6df51a7af9b76592090e44c
Drug	APETx1, Anthopleura elegantissima	SCN2A SCN3A SCN10A	8.29e-07	6	80	3	ctd:C475726
Drug	fenpropathrin	SCN2A SCN3A SCN10A	8.29e-07	6	80	3	ctd:C044267
Drug	2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate	SCN2A SCN3A SCN10A	2.31e-06	8	80	3	ctd:C489827
Drug	benzocaine	SCN2A SCN3A NAGA SCN10A	8.54e-06	37	80	4	CID000002337
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN1A SCN2A SCN3A SCN10A	8.89e-09	10	77	4	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN1A SCN2A SCN3A SCN10A	8.89e-09	10	77	4	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN1A SCN2A SCN3A SCN10A	2.09e-08	12	77	4	DOID:0060170 (implicated_via_orthology)
Disease	anxiety disorder (implicated_via_orthology)	SCN1A SCN2A SCN3A	2.54e-05	22	77	3	DOID:2030 (implicated_via_orthology)
Disease	epilepsy (implicated_via_orthology)	SCN1A SCN2A SCN3A SCN10A DYNC1H1	6.93e-05	163	77	5	DOID:1826 (implicated_via_orthology)
Disease	Seizure, Febrile, Simple	SCN1A SCN2A	1.40e-04	7	77	2	C0149886
Disease	Seizure, Febrile, Complex	SCN1A SCN2A	1.40e-04	7	77	2	C0751057
Disease	thyroid stimulating hormone measurement	FRY CADM1 NRXN3 CAPZB ASXL2 NEB	2.03e-04	323	77	6	EFO_0004748
Disease	Febrile Convulsions	SCN1A SCN2A	2.39e-04	9	77	2	C0009952
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN1A SCN2A	2.39e-04	9	77	2	C3502809
Disease	systolic blood pressure, cigarettes per day measurement	FRY NRXN3	5.15e-04	13	77	2	EFO_0006335, EFO_0006525
Disease	Infantile Severe Myoclonic Epilepsy	SCN1A SCN2A	5.15e-04	13	77	2	C0751122
Disease	MMR-related febrile seizures	SCN1A SCN2A	6.90e-04	15	77	2	EFO_0006519
Disease	Early infantile epileptic encephalopathy with suppression bursts	SCN1A SCN2A	7.88e-04	16	77	2	C0393706
Disease	Febrile seizure (within the age range of 3 months to 6 years)	SCN1A SCN2A	1.00e-03	18	77	2	HP_0002373
Disease	C-X-C motif chemokine 16 measurement	CDH23 ALOX15	1.00e-03	18	77	2	EFO_0010911
Disease	response to platinum based chemotherapy	NRXN3 ANKRD7	1.00e-03	18	77	2	EFO_0004647
Disease	Intellectual Disability	FRY SACS SCN1A SCN3A DIAPH1 DYNC1H1	1.12e-03	447	77	6	C3714756
Disease	FEV/FEC ratio	ASXL1 CADM1 ZSCAN31 VPS13C SPEF2 KIAA0586 CAPZB CDH23 NEB D2HGDH	1.31e-03	1228	77	10	EFO_0004713
Disease	sodium measurement	NRXN3 SCG2 SCN2A	2.51e-03	103	77	3	EFO_0009282

Protein segments in the cluster

Peptide	Gene	Start	Entry
TIIIPENLKPQMKVQ	ACO1	836	P21399
ESLGMLLQPDLQVPK	C2orf16	191	Q68DN1
LQVKQILDTPEMPLE	C2orf42	441	Q9NWW7
MLIGTPPQKLQILVD	BACE2	96	Q9Y5Z0
LVNALAKQVMNLLVP	BPIFB1	176	Q8TDL5
VLSLMLEDLPQEKPQ	CATSPER3	376	Q86XQ3
NNIIMSIRPIQLEPL	CRYBG3	2646	Q68DQ2
LPIIGNMLQIDVKDI	CYP2C8	36	P10632
LMKPLVVEELQQVGL	DNHD1	1951	Q96M86
IQNLIKQMPEPEQLK	DIAPH1	891	O60610
QIAMLPPEQRQSILI	CSTF2	551	P33240
DLMRRLPPQQIEKNL	CAPZB	11	P47756
DNDPVLLNLPMNITI	CDH23	1846	Q9H251
PLVMQLLQGSLPLEK	ASXL1	1106	Q8IXJ9
PLVTQLLQGKDVPME	ASXL2	951	Q76L83
LLQGKDVPMEQILPK	ASXL2	956	Q76L83
APNNVMKLKQIIPLQ	ANO8	971	Q9HCE9
AKINQDPQVMLAPLI	PGM1	526	P36871
RIQQMLPDKLIPSLV	RCOR2	156	Q8IZ40
ILESQNLPKQPPLML	RANBP10	576	Q6VN20
LRTMPPINLQEKQVI	EDC4	66	Q6P2E9
LQQALVPVMKKLVPV	KASH5	486	Q8N6L0
QILPQLSPEQLGMIE	NR1H3	201	Q13133
PNNVPMVNKLLQLEL	OVOS1	326	Q6IE37
QILNNLVTPMLNPLI	OR10D4P	271	Q8NGN7
QRLLKPMCQENLPIE	HAUS2	111	Q9NVX0
PLLEQLENMQPLKGE	KCTD7	136	Q96MP8
LIQKMQIPTLLQEPL	ZBTB33	371	Q86T24
LKPENIMLVDPVRQP	HIPK1	316	Q86Z02
ILMQDLEPLPNNVVL	HORMAD2	166	Q8N7B1
QLIENLGAIQVLPKM	KCNAB1	381	Q14722
ALIPLQAPLKTMLQI	PLTP	406	P55058
VELEVLKGLMQSPQP	SLC10A3	211	P09131
NLGKDMPPDLLLQVL	FAM47B	136	Q8NA70
MNNRDLKPQPDIVLL	NRXN3	1501	Q9Y4C0
QPDGKLLPMVIQLQL	ALOX15	306	P16050
EPPQIIINPARQKMV	IRAK1	656	P51617
PVLPKNALMQLNEIK	ADARB1	76	P78563
LVPPRNLMIDIQKDT	CADM1	141	Q9BY67
PLLVAVINNNPKMVK	ANKRD7	161	Q92527
EILPPKLQAALMQIL	DENND2C	781	Q68D51
MQEELLILGPQVEQK	DNAH14	2276	Q0VDD8
QLKPLVIQAMPTLIE	KPNB1	401	Q14974
DQQMPLALSLPAKIL	FBXO24	346	O75426
LTMEINPKVPVNLLR	DYNC1H1	4126	Q14204
LPIIGNILQLDVKDM	CYP2C18	36	P33260
ELVQQLREKEPGLMP	ENDOV	106	Q8N8Q3
AVLIMLDNQKLVPQP	EMC9	111	Q9Y3B6
VPRDMPLNIFVKIIQ	FRY	446	Q5TBA9
EKRNSLPQIPMLNLE	PTK2B	371	Q14289
RPQPQTLQLDFLMKI	DCTN6	156	O00399
PDQMQVLNPLLVLIF	SLC15A2	341	Q16348
EQVLNMLNVNLDPPL	SACS	3731	Q9NZJ4
MLNVNLDPPLDKVIN	SACS	3736	Q9NZJ4
IQQEMQLIIENPPIN	SLFN13	741	Q68D06
PPGALQLMQQLKALL	D2HGDH	491	Q8N465
QLDPKGLQEMVQLLE	MROH2A	941	A6NES4
AGKMVNVPLEQLPLL	NR6A1	451	Q15406
IMAKIQAAIIQIPKP	SPEF2	206	Q9C093
KLLNDKLQQQLPMPI	SLC26A6	281	Q9BXS9
RNLQIPPEDLIEMLK	SCG2	356	P13521
QMLGEPLVPQLQDKV	SIMC1	831	Q8NDZ2
IAKPNKVQLIAMDLP	SCN3A	1826	Q9NY46
PTDPVLREMEQKLQQ	RNF169	651	Q8NCN4
EMELQKQQDPSLPLL	TGIF2	211	Q9GZN2
LPQPNKLQLIAMDLP	SCN1A	1841	P35498
PQVKTPLLLMLGQED	APEH	661	P13798
IQEKMQLYNITLPPL	CCDC15	871	Q0P6D6
VENNPLVAIEMLLKL	CNOT11	371	Q9UKZ1
LKVKQEPTDIQLQPM	ZSCAN31	146	Q96LW9
ENKNLMPPLLVVQTL	VPS11	746	Q9H270
RELLKLLPQPDPQQM	UBA7	751	P41226
RVEPPLKAVMEQANL	HSPA4L	316	O95757
RIPKPNRNILIQMDL	SCN10A	1776	Q9Y5Y9
LQEMPLVQELPLLKL	TMC4	376	Q7Z404
IAKPNKVQLIAMDLP	SCN2A	1831	Q99250
PQNDIEILKPVNMLL	VPS13C	1826	Q709C8
PLEKPLNLVIMAVVI	SUCNR1	226	Q9BXA5
MLDELLKPTELVPQN	PIAS4	141	Q8N2W9
SNMLLKPPLEQLNIV	TP53RK	166	Q96S44
MILKAILLEENNLIP	USP40	346	Q9NVE5
LLQELLMREEPQPQE	WDR87	2771	Q6ZQQ6
MLKLPDLPQNSVKLQ	KIAA0586	446	Q9BVV6
QPELKAEQQMPLEPV	TXNRD3NB	11	Q6F5E7
ILQNPLMIKINQDPL	NAGA	296	P17050
IMPDIPQIILAKANA	NEB	2006	P20929