Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	CHD5 CHD2 CHD3 CHD4	6.23e-06	37	65	4	GO:0140658
GeneOntologyMolecularFunction	NACHT domain binding	TRIM16 TRIM16L	3.12e-05	3	65	2	GO:0032089
GeneOntologyMolecularFunction	cytokine binding	TRIM16 TNFRSF14 OSMR TRIM16L NRP2	1.59e-04	157	65	5	GO:0019955
GeneOntologyMolecularFunction	heme transmembrane transporter activity	HPX ABCC5	3.70e-04	9	65	2	GO:0015232
GeneOntologyMolecularFunction	ATPase-coupled inorganic anion transmembrane transporter activity	ABCC5 ABCC11	4.62e-04	10	65	2	GO:0043225
GeneOntologyMolecularFunction	ATP hydrolysis activity	CHD5 ABCC5 ABCC11 CHD2 CHD3 AK9 CHD4	5.64e-04	441	65	7	GO:0016887
GeneOntologyMolecularFunction	interleukin-1 binding	TRIM16 TRIM16L	6.74e-04	12	65	2	GO:0019966
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	CHD5 CHD2 CHD3 CHD4	7.83e-04	127	65	4	GO:0008094
GeneOntologyMolecularFunction	ATP-dependent activity	CHD5 ABCC5 ABCC11 CHD2 CHD3 AK9 CHD4 ACSS3	8.23e-04	614	65	8	GO:0140657
GeneOntologyMolecularFunction	ABC-type xenobiotic transporter activity	ABCC5 ABCC11	1.07e-03	15	65	2	GO:0008559
GeneOntologyMolecularFunction	growth factor binding	TRIM16 OSMR TRIM16L NRP2	1.68e-03	156	65	4	GO:0019838
GeneOntologyMolecularFunction	histone binding	CHD5 CHD2 CHD3 CHD4 L3MBTL4	1.71e-03	265	65	5	GO:0042393
GeneOntologyMolecularFunction	peptidoglycan binding	REG1A REG1B	1.72e-03	19	65	2	GO:0042834
GeneOntologyMolecularFunction	helicase activity	CHD5 CHD2 CHD3 CHD4	1.76e-03	158	65	4	GO:0004386
GeneOntologyMolecularFunction	oligosaccharide binding	REG1A REG1B	1.91e-03	20	65	2	GO:0070492
GeneOntologyMolecularFunction	immune receptor activity	CSF2RB OSMR IL4R KLRD1	2.06e-03	165	65	4	GO:0140375
GeneOntologyMolecularFunction	kinase activity	SMG1 NUAK1 PIK3C3 MTOR AK9 CERT1 NRP2 NUAK2	3.26e-03	764	65	8	GO:0016301
GeneOntologyBiologicalProcess	pancreas regeneration	REG1A REG1B	8.60e-06	2	61	2	GO:1990798
GeneOntologyBiologicalProcess	positive regulation of acinar cell proliferation	REG1A REG1B	2.58e-05	3	61	2	GO:1904699
GeneOntologyBiologicalProcess	regulation of acinar cell proliferation	REG1A REG1B	8.55e-05	5	61	2	GO:1904697
GeneOntologyBiologicalProcess	acinar cell proliferation	REG1A REG1B	8.55e-05	5	61	2	GO:1990863
GeneOntologyCellularComponent	CHD-type complex	CHD5 CHD3 CHD4	1.81e-05	17	64	3	GO:0090545
GeneOntologyCellularComponent	NuRD complex	CHD5 CHD3 CHD4	1.81e-05	17	64	3	GO:0016581
GeneOntologyCellularComponent	PML body	TRIM16 MTOR CHD3 TRIM16L	5.87e-04	125	64	4	GO:0016605
MousePheno	increased cardiac jelly amount	CHD4 CERT1	1.31e-05	2	51	2	MP:0031594
Domain	CHDCT2	CHD5 CHD3 CHD4	3.66e-08	3	63	3	PF08074
Domain	CHDNT	CHD5 CHD3 CHD4	3.66e-08	3	63	3	PF08073
Domain	DUF1086	CHD5 CHD3 CHD4	3.66e-08	3	63	3	IPR009462
Domain	DUF1087	CHD5 CHD3 CHD4	3.66e-08	3	63	3	IPR009463
Domain	CHD_N	CHD5 CHD3 CHD4	3.66e-08	3	63	3	IPR012958
Domain	CHD_C2	CHD5 CHD3 CHD4	3.66e-08	3	63	3	IPR012957
Domain	DUF1087	CHD5 CHD3 CHD4	3.66e-08	3	63	3	PF06465
Domain	DUF1086	CHD5 CHD3 CHD4	3.66e-08	3	63	3	PF06461
Domain	DUF1087	CHD5 CHD3 CHD4	3.66e-08	3	63	3	SM01147
Domain	DUF1086	CHD5 CHD3 CHD4	3.66e-08	3	63	3	SM01146
Domain	Chromo_domain	CHD5 CHD2 CHD3 CHD4	1.19e-06	24	63	4	IPR023780
Domain	Chromo	CHD5 CHD2 CHD3 CHD4	1.66e-06	26	63	4	PF00385
Domain	CHROMO_1	CHD5 CHD2 CHD3 CHD4	2.26e-06	28	63	4	PS00598
Domain	CHROMO_2	CHD5 CHD2 CHD3 CHD4	2.26e-06	28	63	4	PS50013
Domain	SNF2_N	CHD5 CHD2 CHD3 CHD4	3.94e-06	32	63	4	IPR000330
Domain	Chromodomain-like	CHD5 CHD2 CHD3 CHD4	3.94e-06	32	63	4	IPR016197
Domain	SNF2_N	CHD5 CHD2 CHD3 CHD4	3.94e-06	32	63	4	PF00176
Domain	Chromo/shadow_dom	CHD5 CHD2 CHD3 CHD4	4.47e-06	33	63	4	IPR000953
Domain	CHROMO	CHD5 CHD2 CHD3 CHD4	4.47e-06	33	63	4	SM00298
Domain	DNA/RNA_helicase_DEAH_CS	CHD5 CHD2 CHD3 CHD4	5.69e-06	35	63	4	IPR002464
Domain	DEAH_ATP_HELICASE	CHD5 CHD2 CHD3 CHD4	7.96e-06	38	63	4	PS00690
Domain	PI3/4_kinase_CS	SMG1 PIK3C3 MTOR	1.62e-05	15	63	3	IPR018936
Domain	-	SMG1 PIK3C3 MTOR	1.99e-05	16	63	3	1.10.1070.11
Domain	PI3Kc	SMG1 PIK3C3 MTOR	1.99e-05	16	63	3	SM00146
Domain	PI3/4_kinase_cat_dom	SMG1 PIK3C3 MTOR	2.88e-05	18	63	3	IPR000403
Domain	PI3_PI4_kinase	SMG1 PIK3C3 MTOR	2.88e-05	18	63	3	PF00454
Domain	PI3_4_KINASE_3	SMG1 PIK3C3 MTOR	2.88e-05	18	63	3	PS50290
Domain	PI3_4_KINASE_1	SMG1 PIK3C3 MTOR	2.88e-05	18	63	3	PS00915
Domain	PI3_4_KINASE_2	SMG1 PIK3C3 MTOR	2.88e-05	18	63	3	PS00916
Domain	WSC	WSCD1 WSCD2	1.11e-04	5	63	2	SM00321
Domain	WSC_carb-bd	WSCD1 WSCD2	1.11e-04	5	63	2	IPR002889
Domain	WSC	WSCD1 WSCD2	1.11e-04	5	63	2	PF01822
Domain	WSC	WSCD1 WSCD2	1.11e-04	5	63	2	PS51212
Domain	FATC	SMG1 MTOR	1.11e-04	5	63	2	PF02260
Domain	FAT	SMG1 MTOR	1.67e-04	6	63	2	PS51189
Domain	FATC	SMG1 MTOR	1.67e-04	6	63	2	PS51190
Domain	FATC_dom	SMG1 MTOR	1.67e-04	6	63	2	IPR003152
Domain	PIK_FAT	SMG1 MTOR	1.67e-04	6	63	2	IPR014009
Domain	FATC	SMG1 MTOR	1.67e-04	6	63	2	SM01343
Domain	HEMATOPO_REC_S_F1	CSF2RB IL4R	3.09e-04	8	63	2	PS01355
Domain	Hempt_rcpt_S_F1_CS	CSF2RB IL4R	3.97e-04	9	63	2	IPR003531
Domain	Helicase_C	CHD5 CHD2 CHD3 CHD4	4.68e-04	107	63	4	PF00271
Domain	HELICc	CHD5 CHD2 CHD3 CHD4	4.68e-04	107	63	4	SM00490
Domain	Helicase_C	CHD5 CHD2 CHD3 CHD4	4.84e-04	108	63	4	IPR001650
Domain	Glyco_transf_8	GLT8D2 GLT8D1	4.95e-04	10	63	2	PF01501
Domain	Glyco_trans_8	GLT8D2 GLT8D1	4.95e-04	10	63	2	IPR002495
Domain	HELICASE_CTER	CHD5 CHD2 CHD3 CHD4	5.02e-04	109	63	4	PS51194
Domain	HELICASE_ATP_BIND_1	CHD5 CHD2 CHD3 CHD4	5.02e-04	109	63	4	PS51192
Domain	DEXDc	CHD5 CHD2 CHD3 CHD4	5.02e-04	109	63	4	SM00487
Domain	Helicase_ATP-bd	CHD5 CHD2 CHD3 CHD4	5.19e-04	110	63	4	IPR014001
Domain	-	WSCD1 CHD5 WSCD2 ABCC5 ABCC11 CHD2 CHD3 AK9 CHD4	8.45e-04	746	63	9	3.40.50.300
Domain	ARM-type_fold	MON2 SMG1 PIK3C3 MTOR USP24 NCBP1	9.74e-04	339	63	6	IPR016024
Domain	-	MAN2A2 FUCA2	9.93e-04	14	63	2	2.60.40.1180
Domain	Glyco_hydro_b	MAN2A2 FUCA2	1.14e-03	15	63	2	IPR013780
Domain	HMG_box_dom	CHD5 CHD3 CHD4	1.38e-03	65	63	3	IPR009071
Domain	Zinc_finger_PHD-type_CS	CHD5 CHD3 CHD4	1.38e-03	65	63	3	IPR019786
Domain	Chromodomain_CS	CHD2 CHD3	1.65e-03	18	63	2	IPR023779
Domain	P-loop_NTPase	WSCD1 CHD5 WSCD2 ABCC5 ABCC11 CHD2 CHD3 AK9 CHD4	2.06e-03	848	63	9	IPR027417
Domain	PHD	CHD5 CHD3 CHD4	2.08e-03	75	63	3	PF00628
Domain	Znf_PHD-finger	CHD5 CHD3 CHD4	2.41e-03	79	63	3	IPR019787
Domain	C_TYPE_LECTIN_1	REG1A REG1B KLRD1	2.50e-03	80	63	3	PS00615
Domain	Lectin_C	REG1A REG1B KLRD1	2.87e-03	84	63	3	PF00059
Domain	CLECT	REG1A REG1B KLRD1	2.87e-03	84	63	3	SM00034
Domain	ABC_membrane	ABCC5 ABCC11	2.95e-03	24	63	2	PF00664
Domain	C_TYPE_LECTIN_2	REG1A REG1B KLRD1	2.97e-03	85	63	3	PS50041
Domain	C-type_lectin-like	REG1A REG1B KLRD1	3.07e-03	86	63	3	IPR001304
Pathway	REACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION	MTOR CHD3 CHD4	6.84e-05	27	42	3	MM15537
Pubmed	Characterization of the CHD family of proteins.	CHD2 CHD3 CHD4	2.49e-08	4	65	3	9326634
Pubmed	Reg proteins direct accumulation of functionally distinct macrophage subsets after myocardial infarction.	REG1A REG1B OSMR	1.24e-07	6	65	3	29850784
Pubmed	SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs.	MTOR NCBP1 EIF3B	5.19e-07	9	65	3	18423201
Pubmed	DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression.	CHD5 CHD3 CHD4	2.79e-06	15	65	3	35695185
Pubmed	Prognostic role of regenerating gene-I in patients with stage-IV head and neck squamous cell carcinoma.	REG1A REG1B	3.44e-06	2	65	2	27539087
Pubmed	Helicobacter and gastrin stimulate Reg1 expression in gastric epithelial cells through distinct promoter elements.	REG1A REG1B	3.44e-06	2	65	2	17463184
Pubmed	The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes.	PIK3C3 MTOR	3.44e-06	2	65	2	21702994
Pubmed	A new serine/threonine protein kinase, Omphk1, essential to ventral body wall formation.	NUAK1 NUAK2	3.44e-06	2	65	2	16715502
Pubmed	Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen.	CHD3 CHD4	3.44e-06	2	65	2	7560064
Pubmed	The expression of REG 1A and REG 1B is increased during acute amebic colitis.	REG1A REG1B	3.44e-06	2	65	2	21586335
Pubmed	Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) rats.	REG1A REG1B	3.44e-06	2	65	2	24587207
Pubmed	Partial amino acid sequence of human pancreatic stone protein, a novel pancreatic secretory protein.	REG1A REG1B	3.44e-06	2	65	2	3541906
Pubmed	Differential expression of reg-I and reg-II genes during aging in the normal mouse.	REG1A REG1B	3.44e-06	2	65	2	8808978
Pubmed	Sulfation of sialic acid is ubiquitous and essential for vertebrate development.	WSCD1 WSCD2	3.44e-06	2	65	2	35864127
Pubmed	Preferential expression of reg I beta gene in human adult pancreas.	REG1A REG1B	3.44e-06	2	65	2	11396963
Pubmed	Synergistic activations of REG I α and REG I β promoters by IL-6 and Glucocorticoids through JAK/STAT pathway in human pancreatic β cells.	REG1A REG1B	3.44e-06	2	65	2	25767811
Pubmed	Isolation, structural determination and expression of a novel reg gene, human regI beta.	REG1A REG1B	3.44e-06	2	65	2	8110835
Pubmed	In vivo evidence for the role of RegI in gastric regeneration: transgenic overexpression of RegI accelerates the healing of experimental gastric ulcers.	REG1A REG1B	3.44e-06	2	65	2	20157293
Pubmed	Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein.	REG1A REG1B	3.44e-06	2	65	2	3108036
Pubmed	The human reg gene encodes pancreatic stone protein.	REG1A REG1B	3.44e-06	2	65	2	2764894
Pubmed	Reg2 inactivation increases sensitivity to Fas hepatotoxicity and delays liver regeneration post-hepatectomy in mice.	REG1A REG1B	3.44e-06	2	65	2	17133485
Pubmed	Reg2 protects mouse insulinoma cells from streptozotocin-induced mitochondrial disruption and apoptosis.	REG1A REG1B	3.44e-06	2	65	2	20919961
Pubmed	Pancreatic acinar-specific overexpression of Reg2 gene offered no protection against either experimental diabetes or pancreatitis in mice.	REG1A REG1B	3.44e-06	2	65	2	20489047
Pubmed	Positional cloning reveals strain-dependent expression of Trim16 to alter susceptibility to bleomycin-induced pulmonary fibrosis in mice.	TRIM16 TRIM16L	3.44e-06	2	65	2	23341783
Pubmed	Reg I protein in healthy and seminoma human testis.	REG1A REG1B	3.44e-06	2	65	2	18712671
Pubmed	Diabetes and tumor formation in transgenic mice expressing Reg I.	REG1A REG1B	3.44e-06	2	65	2	11097844
Pubmed	The estrogen-responsive B box protein: a novel regulator of keratinocyte differentiation.	TRIM16 TRIM16L	3.44e-06	2	65	2	11919186
Pubmed	mReg2 inhibits nuclear entry of apoptosis-inducing factor in mouse insulinoma cells.	REG1A REG1B	3.44e-06	2	65	2	25370781
Pubmed	Pancreatic regenerating gene overexpression in the nonobese diabetic mouse during active diabetogenesis.	REG1A REG1B	3.44e-06	2	65	2	8522062
Pubmed	The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation.	CHD3 CHD4	3.44e-06	2	65	2	7575689
Pubmed	N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue.	REG1A REG1B	3.44e-06	2	65	2	2493268
Pubmed	Isolation and characterization of human reg protein produced in Saccharomyces cerevisiae.	REG1A REG1B	3.44e-06	2	65	2	2226837
Pubmed	Production and characterization of Reg knockout mice: reduced proliferation of pancreatic beta-cells in Reg knockout mice.	REG1A REG1B	3.44e-06	2	65	2	12475793
Pubmed	Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1.	TRIM16 TRIM16L	3.44e-06	2	65	2	34146477
Pubmed	Mechanism of calcite crystal growth inhibition by the N-terminal undecapeptide of lithostathine.	REG1A REG1B	3.44e-06	2	65	2	10625646
Pubmed	Reg2 Expression Is Required for Pancreatic Islet Compensation in Response to Aging and High-Fat Diet-Induced Obesity.	REG1A REG1B	3.44e-06	2	65	2	28009527
Pubmed	Exacerbation of indomethacin-induced small intestinal injuries in Reg I-knockout mice.	REG1A REG1B	3.44e-06	2	65	2	20508157
Pubmed	Glycosyltransferase GLT8D1 and GLT8D2 serve as potential prognostic biomarkers correlated with Tumor Immunity in Gastric Cancer.	GLT8D2 GLT8D1	3.44e-06	2	65	2	37277853
Pubmed	Cellular mechanisms underlying failed beta cell regeneration in offspring of protein-restricted pregnant mice.	REG1A REG1B	3.44e-06	2	65	2	23986224
Pubmed	Heterozygous loss of keratinocyte TRIM16 expression increases melanocytic cell lesions and lymph node metastasis.	TRIM16 TRIM16L	3.44e-06	2	65	2	31342168
Pubmed	What function for human lithostathine?: structural investigations by three-dimensional structure modeling and high-resolution NMR spectroscopy.	REG1A REG1B	3.44e-06	2	65	2	8961348
Pubmed	Reg-II is an exocrine pancreas injury-response product that is up-regulated by keratin absence or mutation.	REG1A REG1B	3.44e-06	2	65	2	17898082
Pubmed	Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene.	REG1A REG1B	3.44e-06	2	65	2	2332435
Pubmed	The Reg gene family and Reg proteins: with special attention to the regeneration of pancreatic beta-cells.	REG1A REG1B	3.44e-06	2	65	2	10526060
Pubmed	Crucial role of Reg I from acinar-like cell cluster touching with islets (ATLANTIS) on mitogenesis of beta cells in EMC virus-induced diabetic mice.	REG1A REG1B	3.44e-06	2	65	2	29935186
Pubmed	Expression of Reg family genes in the gastrointestinal tract of mice treated with indomethacin.	REG1A REG1B	3.44e-06	2	65	2	25747353
Pubmed	Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice.	REG1A REG1B	3.44e-06	2	65	2	3665916
Pubmed	Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain.	REG1A REG1B	3.44e-06	2	65	2	2394826
Pubmed	RegII is a beta-cell protein and autoantigen in diabetes of NOD mice.	REG1A REG1B	3.44e-06	2	65	2	17192462
Pubmed	The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac Hypertrophy.	TRIM16 TRIM16L	3.44e-06	2	65	2	35437018
Pubmed	Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation.	REG1A REG1B	3.44e-06	2	65	2	8654365
Pubmed	No abnormalities of reg1 alpha and reg1 beta gene associated with diabetes mellitus.	REG1A REG1B	3.44e-06	2	65	2	11796176
Pubmed	Isolation, characterization, and distribution of an unusual pancreatic human secretory protein.	REG1A REG1B	3.44e-06	2	65	2	3908481
Pubmed	Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis.	REG1A REG1B	3.44e-06	2	65	2	2525567
Pubmed	TRIM16 protects from OGD/R-induced oxidative stress in cultured hippocampal neurons by enhancing Nrf2/ARE antioxidant signaling via downregulation of Keap1.	TRIM16 TRIM16L	3.44e-06	2	65	2	32251645
Pubmed	Protein-X, Pancreatic Stone-, Pancreatic thread-, reg-protein, P19, lithostathine, and now what? Characterization, structural analysis and putative function(s) of the major non-enzymatic protein of pancreatic secretions.	REG1A REG1B	3.44e-06	2	65	2	12369899
Pubmed	A gene homologous to the reg gene is expressed in the human pancreas.	REG1A REG1B	3.44e-06	2	65	2	8348956
Pubmed	Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development.	CHD3 CHD4	3.44e-06	2	65	2	35568926
Pubmed	A novel gene activated in regenerating islets.	REG1A REG1B	3.44e-06	2	65	2	2963000
Pubmed	Two forms of the major antigenic protein of the dermatomyositis-specific Mi-2 autoantigen.	CHD3 CHD4	3.44e-06	2	65	2	8843877
Pubmed	Structure, chromosomal localization, and expression of mouse reg genes, reg I and reg II. A novel type of reg gene, reg II, exists in the mouse genome.	REG1A REG1B	3.44e-06	2	65	2	8340418
Pubmed	A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development.	CHD5 CHD3 CHD4	4.16e-06	17	65	3	27806305
Pubmed	Keratinocyte Regnase-1, a Downregulator of Skin Inflammation, Contributes to Protection against Tumor Promotion by Limiting Cyclooxygenase-2 Expression.	REG1A REG1B	1.03e-05	3	65	2	36470473
Pubmed	Regenerating gene I regulates interleukin-6 production in squamous esophageal cancer cells.	REG1A REG1B	1.03e-05	3	65	2	20056108
Pubmed	Role and mechanism of REG2 depletion in insulin secretion augmented by glutathione peroxidase-1 overproduction.	REG1A REG1B	1.03e-05	3	65	2	36063729
Pubmed	M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment.	CSF2RB IL4R	1.03e-05	3	65	2	26573801
Pubmed	Pancreatic stone protein/regenerating protein is a potential biomarker for endoplasmic reticulum stress in beta cells.	REG1A REG1B	1.03e-05	3	65	2	30914711
Pubmed	Human regeneration protein/lithostathine genes map to chromosome 2p12.	REG1A REG1B	1.03e-05	3	65	2	8333731
Pubmed	Attenuation of unfolded protein response and apoptosis by mReg2 induced GRP78 in mouse insulinoma cells.	REG1A REG1B	1.03e-05	3	65	2	24801175
Pubmed	Insulin activation of vacuolar protein sorting 34 mediates localized phosphatidylinositol 3-phosphate production at lamellipodia and activation of mTOR/S6K1.	PIK3C3 MTOR	1.03e-05	3	65	2	24582588
Pubmed	MicroRNA-18a promotes cancer progression through SMG1 suppression and mTOR pathway activation in nasopharyngeal carcinoma.	SMG1 MTOR	1.03e-05	3	65	2	31659158
Pubmed	GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity.	CSF2RB IL4R	1.03e-05	3	65	2	19190084
Pubmed	The chromatin-remodeling enzyme CHD3 plays a role in embryonic viability but is dispensable for early vascular development.	CHD3 CHD4	1.03e-05	3	65	2	32658897
Pubmed	Regenerating islet-derived 1α (Reg-1α) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor.	REG1A REG1B	1.03e-05	3	65	2	22158612
Pubmed	hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase.	PIK3C3 MTOR	1.03e-05	3	65	2	16049009
Pubmed	mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival.	PIK3C3 MTOR	1.03e-05	3	65	2	26139536
Pubmed	TRIM16 exerts protective function on myocardial ischemia/reperfusion injury through reducing pyroptosis and inflammation via NLRP3 signaling.	TRIM16 TRIM16L	1.03e-05	3	65	2	36208489
Pubmed	Regulation of ploidy and senescence by the AMPK-related kinase NUAK1.	NUAK1 NUAK2	1.03e-05	3	65	2	19927127
Pubmed	LIGHT-HVEM signaling in keratinocytes controls development of dermatitis.	TNFRSF14 IL4R	1.03e-05	3	65	2	29339444
Pubmed	Cyclin D1 activation through ATF-2 in Reg-induced pancreatic beta-cell regeneration.	REG1A REG1B	1.03e-05	3	65	2	16405968
Pubmed	Loss of RegI in conjunction with gastrin deficiency in mice facilitates efficient gastric ulcer healing but is dispensable for hyperplasia and tumourigenesis.	REG1A REG1B	1.03e-05	3	65	2	19969026
Pubmed	mTOR inhibition rescues osteopenia in mice with systemic sclerosis.	MTOR IL4R	1.03e-05	3	65	2	25534817
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	TRIM16 SMG1 AHCYL1 CHD5 SCN4A ABCC5 NCBP1 CHD2 CHD3 CHD4 ZBTB11 PALB2	1.29e-05	1442	65	12	35575683
Pubmed	Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins.	GLT8D2 GLT8D1 MAN2A2	1.39e-05	25	65	3	2283726
Pubmed	Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system.	GLT8D2 GLT8D1 MAN2A2	1.57e-05	26	65	3	8218172
Pubmed	Role of regenerating gene I in claudin expression and barrier function in the small intestine.	REG1A REG1B	2.06e-05	4	65	2	27055226
Pubmed	REG gene expression in inflamed and healthy colon mucosa explored by in situ hybridisation.	REG1A REG1B	2.06e-05	4	65	2	23519454
Pubmed	Transcriptional activation of Reg2 and Reg3β genes by glucocorticoids and interleukin-6 in pancreatic acinar and islet cells.	REG1A REG1B	2.06e-05	4	65	2	23147030
Pubmed	Intestinally secreted C-type lectin Reg3b attenuates salmonellosis but not listeriosis in mice.	REG1A REG1B	2.06e-05	4	65	2	22252863
Pubmed	MicroRNA-7 directly targets Reg1 in pancreatic cells.	REG1A REG1B	2.06e-05	4	65	2	31166710
Pubmed	Adjuvant immunotherapy increases beta cell regenerative factor Reg2 in the pancreas of diabetic mice.	REG1A REG1B	2.06e-05	4	65	2	20876350
Pubmed	Coordinated age-dependent and pancreatic-specific expression of mouse Reg2Reg3α, and Reg3β genes.	REG1A REG1B	2.06e-05	4	65	2	21410322
Pubmed	Expression of Reg family proteins in embryonic stem cells and its modulation by Wnt/beta-catenin signaling.	REG1A REG1B	2.06e-05	4	65	2	20050810
Pubmed	Regenerating (reg) and insulin genes are expressed in prepancreatic mouse embryos.	REG1A REG1B	2.06e-05	4	65	2	8863190
Pubmed	TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway.	MTOR TRPC5	2.06e-05	4	65	2	28600513
Pubmed	Reg3β deficiency impairs pancreatic tumor growth by skewing macrophage polarization.	REG1A REG1B	2.06e-05	4	65	2	23867474
Pubmed	Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway.	PIK3C3 MTOR	2.06e-05	4	65	2	22024166
Pubmed	NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex.	CHD3 CHD4	2.06e-05	4	65	2	16574654
Pubmed	Regnase-1, an Immunomodulator, Limits the IL-36/IL-36R Autostimulatory Loop in Keratinocytes to Suppress Skin Inflammation.	REG1A REG1B	2.06e-05	4	65	2	29339122
Pubmed	The pancreas responds to remote damage and systemic stress by secretion of the pancreatic secretory proteins PSP/regI and PAP/regIII.	REG1A REG1B	2.06e-05	4	65	2	28415799
Interaction	MBD3L2 interactions	AHCYL1 CHD5 CHD3 CHD4	7.07e-06	41	61	4	int:MBD3L2
Interaction	CDK2AP2 interactions	EEF1G CHD5 CHD3 CHD4	1.45e-05	49	61	4	int:CDK2AP2
Cytoband	12q23.3	NUAK1 WSCD2	1.14e-03	35	65	2	12q23.3
Cytoband	Ensembl 112 genes in cytogenetic band chr12q23	GLT8D2 NUAK1 WSCD2	1.29e-03	150	65	3	chr12q23
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	SMG1 IL4R PALB2	1.90e-03	172	65	3	chr16p12
Cytoband	Ensembl 112 genes in cytogenetic band chr2p12	REG1A REG1B	2.79e-03	55	65	2	chr2p12
Cytoband	Ensembl 112 genes in cytogenetic band chr6q16	MMS22L FAXC	2.89e-03	56	65	2	chr6q16
GeneFamily	PHD finger proteins\|NuRD complex	CHD5 CHD3 CHD4	3.12e-06	12	45	3	1305
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	REG1A REG1B KLRD1	1.44e-04	41	45	3	1298
GeneFamily	Glycosyltransferase family 8	GLT8D2 GLT8D1	2.16e-04	9	45	2	436
GeneFamily	ATP binding cassette subfamily C	ABCC5 ABCC11	4.64e-04	13	45	2	807
GeneFamily	PHD finger proteins	CHD5 CHD3 CHD4	1.46e-03	90	45	3	88
GeneFamily	Transient receptor potential cation channels	PKD2L2 TRPC5	2.20e-03	28	45	2	249
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	MON2 SMG1 USP24 REG1A CHD2 ZBTB11	3.31e-07	188	65	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast-MyoFB-3\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	GLT8D2 HPX FIBCD1 WSCD2 CPZ	1.61e-06	135	65	5	5b13ff740d9f7d96274aebb6b389a80f6004adc7
ToppCell	BAL-Mild-cDC_10\|Mild / Compartment, Disease Groups and Clusters	CSF2RB CHD3 L3MBTL4 NRP2 NUAK2	1.02e-05	197	65	5	c0550d41dd5619b369b590f3d6a61154dd7b2cab
Drug	Cyclacillin [3485-14-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A	WSCD1 MAN2A2 CSF2RB CHD5 SCN4A HPX F13A1	1.38e-06	198	64	7	4358_UP
Disease	complement factor H-related protein 2 measurement	SMIM23 REG1A REG1B	3.58e-05	29	65	3	EFO_0600055
Disease	colon cancer (biomarker_via_orthology)	MTOR REG1A REG1B	8.81e-05	39	65	3	DOID:219 (biomarker_via_orthology)
Disease	lithostathine-1-alpha measurement	REG1A REG1B	9.96e-05	7	65	2	EFO_0801083
Disease	obsolete_interleukin-1 alpha measurement	REG1A REG1B	9.96e-05	7	65	2	EFO_0802653
Disease	cholangiocarcinoma (is_marker_for)	OSBPL7 REG1A IL4R	3.86e-04	64	65	3	DOID:4947 (is_marker_for)
Disease	myocardial infarction (biomarker_via_orthology)	TNFRSF14 REG1A REG1B IL4R	4.36e-04	160	65	4	DOID:5844 (biomarker_via_orthology)
Disease	schizophrenia (implicated_via_orthology)	RELN MAN2A2 MTOR	4.62e-04	68	65	3	DOID:5419 (implicated_via_orthology)
Disease	Congenital Myasthenic Syndromes, Postsynaptic	SCN4A AK9	6.36e-04	17	65	2	C0751883
Disease	sucrose liking measurement	WSCD1 RELN	8.85e-04	20	65	2	EFO_0010157
Disease	Nystagmus	REG1A REG1B	9.77e-04	21	65	2	HP_0000639
Disease	Epileptic encephalopathy	MTOR CHD2	2.00e-03	30	65	2	C0543888
Disease	Major Depressive Disorder	RELN GLT8D1 CSF2RB MTOR	2.05e-03	243	65	4	C1269683

Protein segments in the cluster

Peptide	Gene	Start	Entry
EASIALLHDSFWWWF	FAM227B	196	Q96M60
LLHDSFWWWFLHKFR	FAM227B	201	Q96M60
PNLHNWSGDWSFWIS	GRAMD1C	46	Q8IYS0
WSGDWSFWISSSTYK	GRAMD1C	51	Q8IYS0
SWWSHKVDNAYWLWT	EIF3B	671	P55884
FFVKWAGLSYWHCSW	CHD5	511	Q8TDI0
HFWKWSEWSGQNFTT	OSMR	411	Q99650
SKWTNYIHGWQDRWV	CERT1	31	Q9Y5P4
DLSWNQSISFFGWWA	FAXC	16	Q5TGI0
WFSHHLSNFQFRWSW	NCBP1	416	Q09161
VWEWLSDDGSWTAYE	DTX2	111	Q86UW9
HRSKWFVSESFWNWL	MMS22L	306	Q6ZRQ5
DGDWFWWENSHVFTD	TPO	666	P07202
IFSFWWLSYWLEQGS	ABCC11	821	Q96J66
GWMYDHAKWLRTTWA	NRP2	656	O60462
WEGASQSWYNLWKEF	LIPG	416	Q9Y5X9
TKDSVWNYHCWNEAW	F13A1	366	P00488
AAAQGAWSWEWYLKE	L3MBTL4	46	Q8NA19
WDFPSVHNDLWESWF	GLT8D2	321	Q9H1C3
WGRTASYTDVWEKWY	GLT8D1	336	Q68CQ7
WAAWNTWYRIGSEST	MON2	1241	Q7Z3U7
EWWTHLRLNEGFASW	NPEPPSL1	366	A6NEC2
WWQPYHSSQREDVWA	RELN	841	P78509
LDAWQWEKLYTWHFA	PALB2	901	Q86YC2
STWWLSYWIKQGSGN	ABCC5	876	O15440
HEGFTLWGSEYSWNW	FUCA2	136	Q9BTY2
LWGSEYSWNWNAIDE	FUCA2	141	Q9BTY2
GQHKAHFWTWTNSWE	GALNS	396	P34059
TWHLQRFWGASGYFW	FAXDC2	46	Q96IV6
YNGIWSEWSEARSWD	CSF2RB	421	P32927
TWSEWSPSTKWHNSY	IL4R	211	P24394
SADGSKPWWWSYFTS	CPZ	626	Q66K79
WKGWSYIHSTWESEE	CHD2	311	O14647
FVKWVGLSYWHCSWA	CHD3	551	Q12873
FLWAEVSFFAKWWDN	MAN2A2	211	P49641
YADGVEWSSWTGWQY	FIBCD1	431	Q8N539
EWSSWTGWQYSLKFS	FIBCD1	436	Q8N539
WEHFDKDGWSLWYSE	EEF1G	311	P26641
KWQGMSYWHCSWVSE	CHD4	546	Q14839
HFSWYWLWYTTKNCV	PIDD1	586	Q9HB75
DSSGKEWWVTNNTYW	OSBPL7	811	Q9BZF2
WHWSSGSLVSYKSWG	REG1A	111	P05451
WHWSSGSLVSYKSWD	REG1B	111	P48304
WYKAWHAWAVMNFEA	MTOR	1786	P42345
HYWRLDTSRDGWHSW	HPX	281	P02790
YVIDGFHSKWWVWNE	AK9	1581	Q5TCS8
DSWYANDTWNSHASW	SCN4A	316	P35499
YEHEVDWWSKLFWAT	FER1L5	1381	A0AVI2
GWWFLSWFNNGIHNY	GGTA1	51	Q4G0N0
AVFAWKGESEDDFWW	AHCYL1	196	O43865
TSYKAFSTRWNWNEW	PIK3C3	76	Q8NEB9
AKSWAALASWAYRWG	SMG1	1616	Q96Q15
EHCSTYKSHLWEWAW	SMIM23	136	A6NLE4
YKSHLWEWAWALGRE	SMIM23	141	A6NLE4
TIEDIANHWWVNWGY	NUAK1	296	O60285
DVASHWWVNWGYATR	NUAK2	296	Q9H093
WWAASDLGWVVGHSY	ACSS3	336	Q9H6R3
QTWHYLSKTYWWRGI	ZBTB11	91	O95625
SGQPWNFHASTSWYW	NUFIP1	106	Q9UHK0
WRYSTSNTNSPWHWG	PKD2L2	176	Q9NZM6
FYWEFNMGHSWNWAF	TRIM51G	341	A0A3B3IT33
YFKENSHHWSWAVQW	USP24	2516	Q9UPU5
KAGAGTSSSHWVWWF	TNFRSF14	191	Q92956
SWSLQWNGKEFTAWY	TRIM16	466	O95361
KHSYWEFAEWIPLAW	GTF3C2	321	Q8WUA4
EMWDGGFTEYIHDWW	TRPC5	421	Q9UL62
SYASWWSSHVLDWLK	WSCD1	466	Q658N2
NYAPWWATHTLDWLK	WSCD2	456	Q2TBF2
HDCSHWFYTRWKDWE	ZRANB1	471	Q9UGI0
WKDWESWYSQSFGLH	ZRANB1	481	Q9UGI0
WSLQWNGKEFTAWYS	TRIM16L	251	Q309B1
WIGLSYSEEHTAWLW	KLRD1	116	Q13241