Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	iron-responsive element binding	ACO1 IREB2	6.70e-05	3	95	2	GO:0030350
GeneOntologyMolecularFunction	aconitate hydratase activity	ACO1 IREB2	6.70e-05	3	95	2	GO:0003994
GeneOntologyCellularComponent	BRCA1-B complex	BRIP1 BARD1	1.19e-04	4	94	2	GO:0070532
Domain	Aconitase/IRP2	ACO1 IREB2	2.51e-05	2	94	2	IPR006249
Domain	AconitaseA/IPMdHydase_ssu_swvl	ACO1 IREB2	7.49e-05	3	94	2	IPR000573
Domain	Aconitase_C	ACO1 IREB2	7.49e-05	3	94	2	PF00694
Domain	-	ACO1 IREB2	7.49e-05	3	94	2	3.30.499.10
Domain	Acoase/IPM_deHydtase_lsu_aba	ACO1 IREB2	7.49e-05	3	94	2	IPR001030
Domain	-	ACO1 IREB2	7.49e-05	3	94	2	3.40.1060.10
Domain	-	ACO1 IREB2	7.49e-05	3	94	2	3.20.19.10
Domain	Acoase/IPM_deHydtase	ACO1 IREB2	7.49e-05	3	94	2	IPR015937
Domain	Acnase/IPM_dHydase_lsu_aba_1/3	ACO1 IREB2	7.49e-05	3	94	2	IPR015931
Domain	Aconitase/IPMdHydase_lsu_aba_2	ACO1 IREB2	7.49e-05	3	94	2	IPR015932
Domain	ACONITASE_1	ACO1 IREB2	7.49e-05	3	94	2	PS00450
Domain	Aconitase/3IPM_dehydase_swvl	ACO1 IREB2	7.49e-05	3	94	2	IPR015928
Domain	Aconitase	ACO1 IREB2	7.49e-05	3	94	2	PF00330
Domain	Aconitase_4Fe-4S_BS	ACO1 IREB2	7.49e-05	3	94	2	IPR018136
Domain	ACONITASE_2	ACO1 IREB2	7.49e-05	3	94	2	PS01244
Domain	LamGL	PAPPA USH2A	1.49e-04	4	94	2	SM00560
Domain	LamG-like	PAPPA USH2A	1.49e-04	4	94	2	IPR006558
Domain	SEFIR	IL17RA IL17RD	3.71e-04	6	94	2	PF08357
Domain	SEFIR_dom	IL17RA IL17RD	3.71e-04	6	94	2	IPR013568
Domain	SEFIR	IL17RA IL17RD	3.71e-04	6	94	2	PS51534
Domain	Myosin_TH1	MYO1G MYO1F	5.18e-04	7	94	2	PF06017
Domain	Myosin_TH1	MYO1G MYO1F	5.18e-04	7	94	2	IPR010926
Domain	TH1	MYO1G MYO1F	5.18e-04	7	94	2	PS51757
Domain	BEACH	NBEAL2 WDR81	8.82e-04	9	94	2	PS50197
Domain	Beach	NBEAL2 WDR81	8.82e-04	9	94	2	PF02138
Domain	-	NBEAL2 WDR81	8.82e-04	9	94	2	1.10.1540.10
Domain	Beach	NBEAL2 WDR81	8.82e-04	9	94	2	SM01026
Domain	BEACH_dom	NBEAL2 WDR81	8.82e-04	9	94	2	IPR000409
Domain	Myosin_head_motor_dom	MYO1G MYO1F MYO15A	9.17e-04	38	94	3	IPR001609
Domain	MYOSIN_MOTOR	MYO1G MYO1F MYO15A	9.17e-04	38	94	3	PS51456
Domain	Myosin_head	MYO1G MYO1F MYO15A	9.17e-04	38	94	3	PF00063
Domain	MYSc	MYO1G MYO1F MYO15A	9.17e-04	38	94	3	SM00242
Domain	Laminin_G_2	CELSR1 COL11A2 USH2A	1.07e-03	40	94	3	PF02210
Domain	VIT	VWA5B2 ITIH1	1.10e-03	10	94	2	PS51468
Domain	VIT	VWA5B2 ITIH1	1.10e-03	10	94	2	IPR013694
Domain	-	CELSR1 COL11A2 PAPPA USH2A	1.35e-03	95	94	4	2.60.120.200
Domain	fn3	FNDC3B SDK2 UMODL1 USH2A SDK1	1.36e-03	162	94	5	PF00041
Domain	LamG	CELSR1 COL11A2 USH2A	1.41e-03	44	94	3	SM00282
Domain	ASX_HYDROXYL	CELSR1 UMODL1 NCAN LTBP2	1.63e-03	100	94	4	PS00010
Domain	EGF_1	CELSR1 UMODL1 NCAN LTBP2 USH2A SSPOP	1.83e-03	255	94	6	PS00022
Domain	EGF-type_Asp/Asn_hydroxyl_site	CELSR1 UMODL1 NCAN LTBP2	2.02e-03	106	94	4	IPR000152
Domain	Sushi	NCAN PAPPA CSMD2	2.28e-03	52	94	3	PF00084
Domain	FN3	FNDC3B SDK2 UMODL1 USH2A SDK1	2.43e-03	185	94	5	SM00060
Domain	CCP	NCAN PAPPA CSMD2	2.54e-03	54	94	3	SM00032
Domain	SUSHI	NCAN PAPPA CSMD2	2.82e-03	56	94	3	PS50923
Domain	Sushi_SCR_CCP_dom	NCAN PAPPA CSMD2	2.97e-03	57	94	3	IPR000436
Domain	Laminin_G	CELSR1 COL11A2 USH2A	3.12e-03	58	94	3	IPR001791
Domain	EMI	UMODL1 SSPOP	3.24e-03	17	94	2	PS51041
Domain	FN3	FNDC3B SDK2 UMODL1 USH2A SDK1	3.33e-03	199	94	5	PS50853
Domain	EGF_CA	CELSR1 UMODL1 NCAN LTBP2	3.36e-03	122	94	4	SM00179
Domain	EGF-like_Ca-bd_dom	CELSR1 UMODL1 NCAN LTBP2	3.56e-03	124	94	4	IPR001881
Domain	FN3_dom	FNDC3B SDK2 UMODL1 USH2A SDK1	4.10e-03	209	94	5	IPR003961
Domain	ConA-like_dom	CELSR1 COL11A2 NBEAL2 PAPPA USH2A	5.00e-03	219	94	5	IPR013320
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	VWA5B2 PNPLA2 CELSR1 ARAP3 PER2 PCNX3 SZT2 SHISA5 NBEAL2 HELZ2 FRMD8 PLXND1 CHPF IL17RD ABCA7 TPCN1	5.91e-08	1105	96	16	35748872
Pubmed	Subcellular localization of iron regulatory proteins to Golgi and ER membranes.	ACO1 IREB2	7.54e-06	2	96	2	16144863
Pubmed	Electron tomography of degenerating neurons in mice with abnormal regulation of iron metabolism.	ACO1 IREB2	7.54e-06	2	96	2	15866737
Pubmed	A regulated RNA binding protein also possesses aconitase activity.	ACO1 IREB2	7.54e-06	2	96	2	1946430
Pubmed	Association of BARD1 and BRIP1 Gene Polymorphisms with the Risk of Uveal Melanoma.	BRIP1 BARD1	7.54e-06	2	96	2	37561379
Pubmed	Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes.	ACO1 IREB2	7.54e-06	2	96	2	16283625
Pubmed	Iron regulatory proteins 1 and 2 have opposing roles in regulating inflammation in bacterial orchitis.	ACO1 IREB2	7.54e-06	2	96	2	38301068
Pubmed	Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis.	ACO1 IREB2	7.54e-06	2	96	2	14726953
Pubmed	Effect of hypoxia on the binding and subcellular distribution of iron regulatory proteins.	ACO1 IREB2	7.54e-06	2	96	2	17200797
Pubmed	FANCC suppresses short telomere-initiated telomere sister chromatid exchange.	FANCC TERT	7.54e-06	2	96	2	20022886
Pubmed	In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation.	ACO1 IREB2	7.54e-06	2	96	2	19533074
Pubmed	Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2.	ACO1 IREB2	7.54e-06	2	96	2	15831703
Pubmed	Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins.	ACO1 IREB2	7.54e-06	2	96	2	25771171
Pubmed	Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo.	ACO1 IREB2	7.54e-06	2	96	2	15208438
Pubmed	Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements.	ACO1 IREB2	7.54e-06	2	96	2	8262972
Pubmed	Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy.	SDK2 SDK1	7.54e-06	2	96	2	15213259
Pubmed	Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency.	ACO1 IREB2	7.54e-06	2	96	2	16503547
Pubmed	Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide.	ACO1 IREB2	7.54e-06	2	96	2	21566147
Pubmed	Self-association and ligand-induced conformational changes of iron regulatory proteins 1 and 2.	ACO1 IREB2	7.54e-06	2	96	2	15938636
Pubmed	Iron regulatory proteins secure mitochondrial iron sufficiency and function.	ACO1 IREB2	7.54e-06	2	96	2	20674864
Pubmed	Excess capacity of the iron regulatory protein system.	ACO1 IREB2	7.54e-06	2	96	2	17604281
Pubmed	Definition of the critical domains required for homophilic targeting of mouse sidekick molecules.	SDK2 SDK1	7.54e-06	2	96	2	15703275
Pubmed	Architecture of cell-cell adhesion mediated by sidekicks.	SDK2 SDK1	7.54e-06	2	96	2	30150416
Pubmed	Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein.	ACO1 IREB2	7.54e-06	2	96	2	2172968
Pubmed	Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation.	FANCC TERT	7.54e-06	2	96	2	9582020
Pubmed	Genetic polymorphism of the iron-regulatory protein-1 and -2 genes in age-related macular degeneration.	ACO1 IREB2	7.54e-06	2	96	2	22331484
Pubmed	Thermodynamic study of the BRCT domain of BARD1 and its interaction with the -pSER-X-X-Phe- motif-containing BRIP1 peptide.	BRIP1 BARD1	7.54e-06	2	96	2	20451671
Pubmed	Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation.	ACO1 IREB2	7.54e-06	2	96	2	7983023
Pubmed	Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina.	SDK2 SDK1	7.54e-06	2	96	2	12230981
Pubmed	Iron regulatory proteins increase neuronal vulnerability to hydrogen peroxide.	ACO1 IREB2	7.54e-06	2	96	2	18655771
Pubmed	Effects of iron regulatory protein regulation on iron homeostasis during hypoxia.	ACO1 IREB2	7.54e-06	2	96	2	12855587
Pubmed	Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo.	ACO1 IREB2	7.54e-06	2	96	2	15604406
Pubmed	The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation.	ACO1 IREB2	7.54e-06	2	96	2	8041788
Pubmed	Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms.	ACO1 IREB2	7.54e-06	2	96	2	38773499
Pubmed	Genotypic and phenotypic characteristics of 12 chinese children with glycogen storage diseases.	PHKA2 GAA	7.54e-06	2	96	2	36105079
Pubmed	Molecular basis of sidekick-mediated cell-cell adhesion and specificity.	SDK2 SDK1	7.54e-06	2	96	2	27644106
Pubmed	Biological insights from 108 schizophrenia-associated genetic loci.	CYP26B1 NCAN IREB2 PLCL1 MYO15A ENKD1 ITIH1	2.18e-05	303	96	7	25056061
Pubmed	Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum.	ACO1 IREB2	2.26e-05	3	96	2	18177727
Pubmed	Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery.	ACO1 IREB2	2.26e-05	3	96	2	19965627
Pubmed	BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.	BRIP1 BARD1	2.26e-05	3	96	2	11301010
Pubmed	The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption.	ACO1 IREB2	2.26e-05	3	96	2	23395174
Pubmed	Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice.	ACO1 IREB2	2.26e-05	3	96	2	22003390
Pubmed	F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis.	ACO1 IREB2	2.26e-05	3	96	2	23135277
Pubmed	FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth.	FRMD8 FRMD8P1	2.26e-05	3	96	2	37527040
Pubmed	Iron regulatory protein (IRP)-mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow.	ACO1 IREB2	2.26e-05	3	96	2	36197975
Pubmed	IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation.	ACO1 IREB2	2.26e-05	3	96	2	23777768
Pubmed	Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins.	ACO1 IREB2	2.26e-05	3	96	2	21940823
Pubmed	A novel breast cancer-associated BRIP1 (FANCJ/BACH1) germ-line mutation impairs protein stability and function.	BRIP1 BARD1	2.26e-05	3	96	2	18628483
Pubmed	The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth.	FRMD8 FRMD8P1	2.26e-05	3	96	2	36720499
Pubmed	Iron homeostasis during transfusional iron overload in beta-thalassemia and sickle cell disease: changes in iron regulatory protein, hepcidin, and ferritin expression.	ACO1 IREB2	2.26e-05	3	96	2	17613866
Pubmed	Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection.	ACO1 IREB2	2.26e-05	3	96	2	26190773
Pubmed	The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4.	PER2 EIF2AK4	4.51e-05	4	96	2	31522764
Pubmed	Impact of RING and BRCT domain mutations on BRCA1 protein stability, localization and recruitment to DNA damage.	BRIP1 BARD1	4.51e-05	4	96	2	20681793
Pubmed	Iron regulatory protein 1 sustains mitochondrial iron loading and function in frataxin deficiency.	ACO1 IREB2	4.51e-05	4	96	2	25651183
Pubmed	Essential role of systemic iron mobilization and redistribution for adaptive thermogenesis through HIF2-α/hepcidin axis.	ACO1 IREB2	4.51e-05	4	96	2	34593646
Pubmed	Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina.	ACO1 IREB2	4.51e-05	4	96	2	15354085
Pubmed	FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex.	FRMD8 FRMD8P1	7.50e-05	5	96	2	29897336
Pubmed	iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.	FRMD8 FRMD8P1	7.50e-05	5	96	2	29897333
Pubmed	The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges.	SDK2 SDK1	7.50e-05	5	96	2	34545809
Pubmed	Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response.	BRIP1 BARD1	7.50e-05	5	96	2	17525342
Pubmed	Activation of BRCA1/BRCA2-associated helicase BACH1 is required for timely progression through S phase.	BRIP1 BARD1	7.50e-05	5	96	2	17664283
Pubmed	Control of iron homeostasis by an iron-regulated ubiquitin ligase.	ACO1 IREB2	7.50e-05	5	96	2	19762596
Pubmed	Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.	FANCC BRIP1 BARD1	1.05e-04	33	96	3	19714462
Pubmed	Semaphorin3E-PlexinD1 signaling in coronary artery and lymphatic vessel development with clinical implications in myocardial recovery.	FLT4 PLXND1	1.12e-04	6	96	2	33870127
Pubmed	Expression and Roles of the Immunoglobulin Superfamily Recognition Molecule Sidekick1 in Mouse Retina.	SDK2 SDK1	1.12e-04	6	96	2	30687002
Pubmed	HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.	ACO1 IREB2	1.12e-04	6	96	2	24778179
Pubmed	Reporter-nanobody fusions (RANbodies) as versatile, small, sensitive immunohistochemical reagents.	SDK2 SDK1	1.12e-04	6	96	2	29440485
Pubmed	Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia.	MYO1G MYO1F	1.12e-04	6	96	2	12486594
Pubmed	Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices.	ARAP3 MYO1F	1.12e-04	6	96	2	11804589
Pubmed	HP1 regulates the localization of FANCJ at sites of DNA double-strand breaks.	BRIP1 BARD1	1.12e-04	6	96	2	27399284
Pubmed	Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNF-α pathway.	FRMD8 FRMD8P1	1.12e-04	6	96	2	29776906
Pubmed	An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis.	ACO1 IREB2	1.12e-04	6	96	2	19762597
Pubmed	PALB2 is an integral component of the BRCA complex required for homologous recombination repair.	BRIP1 BARD1	1.12e-04	6	96	2	19369211
Pubmed	An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.	ACO1 IREB2	1.57e-04	7	96	2	31229404
Pubmed	RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites.	BRIP1 BARD1	1.57e-04	7	96	2	17525341
Pubmed	IL-17A expression by both T cells and non-T cells contribute to HSV-IL-2-induced CNS demyelination.	IL17RA IL17RD	2.09e-04	8	96	2	36817487
Pubmed	Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination.	BRIP1 BARD1	2.09e-04	8	96	2	23585894
Pubmed	A study of genes that may modulate the expression of hereditary hemochromatosis: transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (IRP)-1 and -2, and hepcidin.	ACO1 IREB2	2.09e-04	8	96	2	11783942
Pubmed	CLIPR-59 regulates TNF-α-induced apoptosis by controlling ubiquitination of RIP1.	CYLD TRADD	2.09e-04	8	96	2	22297296
Pubmed	Functional proteomics mapping of a human signaling pathway.	PHKA2 PNPLA2 FLT4 TUSC3 U2AF2 PAPPA CHPF SDK1	2.37e-04	591	96	8	15231748
Pubmed	Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance.	BRIP1 BARD1	2.68e-04	9	96	2	28398198
Pubmed	Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2.	MYO15A USH2A	2.68e-04	9	96	2	23144817
Pubmed	Conserved overlapping gene arrangement, restricted expression, and biochemical activities of DNA polymerase ν (POLN).	BRIP1 BARD1	2.68e-04	9	96	2	26269593
Pubmed	Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine.	PNPLA2 LSS	2.68e-04	9	96	2	21498505
Pubmed	SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell death.	CYLD TRADD	2.68e-04	9	96	2	27458237
Pubmed	Spatiotemporal regulation of GLI target genes in the mammalian limb bud.	SDK2 FRMD8 GATA5 FRMD8P1 TPCN1	2.80e-04	207	96	5	26238476
Pubmed	A mouse knockout library for secreted and transmembrane proteins.	CDAN1 ERFE FNDC3B NBEAL2 CHPF IL17RD LNX1	2.93e-04	460	96	7	20562862
Pubmed	PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.	SDK2 PLXND1 SDK1 LRRC15	3.18e-04	117	96	4	17145500
Pubmed	Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1.	CYLD TRADD	3.34e-04	10	96	2	34853447
Pubmed	PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair.	BRIP1 BARD1	3.34e-04	10	96	2	25252691
Pubmed	Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers.	BRIP1 BARD1	4.08e-04	11	96	2	19584272
Pubmed	Mitochondrial retention of Opa1 is required for mouse embryogenesis.	WNT1 LRRC15	4.08e-04	11	96	2	20652258
Pubmed	Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo.	FLT4 CYP26B1	4.08e-04	11	96	2	24361262
Pubmed	An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.	SDK2 PLXND1 SDK1	4.08e-04	52	96	3	26633812
Pubmed	Comparative mapping of 50 human chromosome 9 loci in the laboratory mouse.	FANCC ACO1 PAPPA	4.32e-04	53	96	3	7774911
Pubmed	Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.	BRIP1 BARD1	4.89e-04	12	96	2	16391231
Pubmed	Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.	CYLD TRADD	4.89e-04	12	96	2	27552911
Pubmed	Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development.	CELSR1 FLT4	5.77e-04	13	96	2	27789626
Pubmed	Semaphorin 3G Provides a Repulsive Guidance Cue to Lymphatic Endothelial Cells via Neuropilin-2/PlexinD1.	FLT4 PLXND1	5.77e-04	13	96	2	27880905
Pubmed	Common single-nucleotide polymorphisms in DNA double-strand break repair genes and breast cancer risk.	BRIP1 BARD1	5.77e-04	13	96	2	19064565
Interaction	D2HGDH interactions	VWA5B2 PNPLA2 ARAP3 LSS MAP3K6 VPS13B SHKBP1	5.88e-06	146	95	7	int:D2HGDH
GeneFamily	Ankyrin repeat domain containing\|BRCA1 B complex	BRIP1 BARD1	7.37e-05	4	64	2	1335
GeneFamily	Myosins, class I	MYO1G MYO1F	3.41e-04	8	64	2	1097
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEAL2 WDR81	4.37e-04	9	64	2	1230
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	NCAN PAPPA CSMD2	1.08e-03	57	64	3	1179
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	FANCC BRIP1	2.25e-03	20	64	2	548
GeneFamily	Fibronectin type III domain containing	FNDC3B SDK2 USH2A SDK1	2.48e-03	160	64	4	555
ToppCell	droplet-Kidney-nan-18m-Endothelial-kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ARAP3 CYP26B1 WNT1 TRO GATA5	2.28e-06	176	96	6	5386386619cf173939d3c117b20e6f27ab397993
ToppCell	droplet-Kidney-nan-18m-Endothelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ARAP3 CYP26B1 WNT1 TRO GATA5	2.28e-06	176	96	6	820edade963768e4bfd86b554da4cd7100567ac8
ToppCell	Control-Myeloid-MoAM2,_CCL18\|Myeloid / Condition, Lineage and Cell class	CELSR1 SYDE2 LTBP2 PLCL1 PLXND1 TPCN1	2.35e-06	177	96	6	470f54fe2b21c7350ea471e02039461a3808f700
ToppCell	droplet-Kidney-nan-3m-Endothelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ARAP3 CYP26B1 TRO GATA5 LRRC15	2.77e-06	182	96	6	f4a5f1c3a04c0566eb96607dab7a0d9a5ebc3fd1
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ARAP3 CYP26B1 TRO PLXND1 PGM5	3.88e-06	193	96	6	826b8dd801298b3e0cd76232feae5a14026b8806
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ARAP3 CYP26B1 TRO PLXND1 PGM5	3.88e-06	193	96	6	87d3a577d37fb0cb4b6313c596310de452bc3872
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ARAP3 CYP26B1 TRO PLXND1 PGM5	3.88e-06	193	96	6	d485634c564b268e344b6a2863c26f6adaec9e38
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_immature\|E16.5-samps / Age Group, Lineage, Cell class and subclass	GABRQ PAPPA EIF2AK4 SDK1 LRRC15	8.89e-06	129	96	5	5e4783cc63afdeaebdfaecb72f95f3efc8d3c4a3
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PHKA2 PLLP FLT4 IL17RD SSPOP	1.62e-05	146	96	5	cffa91d76606f74553d81150adbb23b003746316
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	PHKA2 PLLP FLT4 IL17RD SSPOP	2.03e-05	153	96	5	e7d20c88466ff81db613869cf7a6a4bb95fd6c2f
ToppCell	10x5'-bone_marrow-Lymphocytic_B-GC_B_(I)\|bone_marrow / Manually curated celltypes from each tissue	BRIP1 GARIN5A PXMP2 TERT ENKD1	2.30e-05	157	96	5	d4da4057917dda066da0f2aac2621fdaf1fb943b
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLEKHG6 MYO15A IL17RD ABCA7 SDK1	3.18e-05	168	96	5	de0b00bc405c898d08a06b2e585fb62c0ab9a66e
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-8\|TCGA-Thryoid / Sample_Type by Project: Shred V9	ARAP3 FRMD8 PLXND1 IL17RD SDK1	3.18e-05	168	96	5	00646601548b0fee42ae16bfa5e93603bc7c5129
ToppCell	facs-Marrow-KLS-3m-Hematologic-Unknown_Progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC3B NCAN PAWR CHPF SSPOP	3.27e-05	169	96	5	b798b91567d2f49082e2d8a337169f241c8d2080
ToppCell	Frontal_cortex-Macroglia\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	S1PR5 PLLP COL11A2 PXMP2 FRMD8	3.65e-05	173	96	5	ac70145e093ef0df43811e7c67a865ccdd45a5e3
ToppCell	Control-Myeloid-MoAM2,_CCL18\|Control / Condition, Lineage and Cell class	CELSR1 LTBP2 PLCL1 PLXND1 TPCN1	3.76e-05	174	96	5	4c64ff5666812fb4efa440ba4faeca51d916d68e
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SDK2 APCDD1 GABRQ LTBP2 HTRA4	4.19e-05	178	96	5	27497dbfcf9bb4dd0bf7caa0bd78c7e85f5c18ee
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SDK2 APCDD1 GABRQ LTBP2 HTRA4	4.19e-05	178	96	5	d348a9550db940d204706529759dc51e30506b5f
ToppCell	droplet-Spleen-SPLEEN-1m-Lymphocytic-plasma_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC3B CHPF SSPOP GAA TPCN1	4.19e-05	178	96	5	b902059c3f861108fc64cbdc05e6f44378f5be2c
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-10\|TCGA-Colorectal / Sample_Type by Project: Shred V9	FLT4 TRO MYO1F CSMD2 SDK1	4.30e-05	179	96	5	cc079ba015326dccde955c5eafa3e4a2e40de192
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ARAP3 TUSC3 PLXND1 PGM5	4.65e-05	182	96	5	b1ec2015aad1181eac1bbf8d48ad6f2f7ed24a01
ToppCell	facs-Lung-EPCAM-24m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SDK2 BRIP1 APCDD1 LSS LTBP2	4.77e-05	183	96	5	0e8fb371d8eac777451c76f41d53577f5dfb740d
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLT4 ARAP3 CYP26B1 PLCL1 PLXND1	4.77e-05	183	96	5	dc19857b66dcadbf7c87de91f7b1f4e8ef2857ed
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLT4 ARAP3 CYP26B1 PLCL1 PLXND1	4.77e-05	183	96	5	4759560e5b4f4e5a00e5f933e3451a27c7c4aefe
ToppCell	facs-Lung-EPCAM-24m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SDK2 BRIP1 APCDD1 LSS LTBP2	4.77e-05	183	96	5	cbc3b00faa7e4e0dbbbc8ee105467c65241c7470
ToppCell	10x3'2.3-week_12-13-Mesenchymal_myocytic-stroma-muscle\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SDK2 TUSC3 FBXW4 PAPPA PLCL1	5.03e-05	185	96	5	0094f9baddb20214d2a2c166f1637d1a9cf1169a
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	S1PR5 FNDC3B ANGEL1 PLXND1 LARP4	5.03e-05	185	96	5	7925519b855f76444a0b57382ce35d89457b0b14
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ARAP3 CYP26B1 PLXND1 PGM5	5.16e-05	186	96	5	2cae34336f184f971f7c8684cc27c23a4e7369ed
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ARAP3 CYP26B1 PLXND1 PGM5	5.16e-05	186	96	5	90d53c2597a9f3a2b39afba75adfc54f1ca0a4db
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLT4 BRIP1 ARAP3 PLXND1 PGM5	5.29e-05	187	96	5	35c382c0aabd46906113e5db30ea24bb8e658899
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ARAP3 CYP26B1 PLXND1 PGM5	5.43e-05	188	96	5	0aa8747c2931b0c91f6d78bb2db8fd8ede6dd559
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ARAP3 CYP26B1 PLXND1 PGM5	5.70e-05	190	96	5	a08c5929b05a4969852e351a93c4e4deb4c8d5b6
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ARAP3 CYP26B1 PLXND1 PGM5	5.70e-05	190	96	5	25525fee1da8a808034d9c916159fd0b6b26bce8
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-stalk_early\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SYDE2 NBEAL2 PAWR TERT LRRC15	5.70e-05	190	96	5	9f5f65869dad9a43ac94f81f9a19c72ffe5adc3c
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PAPPA PLCL1 GATA5 SDK1 PGM5	5.85e-05	191	96	5	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NBEAL2 MYO1F IL17RA PLXND1 GAA	6.14e-05	193	96	5	1db487e5f81849740d57cc3e2b5739e8f7581efb
ToppCell	Parenchymal-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SDK2 COL11A2 TRO TERT PIWIL3	6.14e-05	193	96	5	df4afb4848eb9d7d8d39e5c612919663cbbb2514
ToppCell	Parenchymal-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SDK2 COL11A2 TRO TERT PIWIL3	6.14e-05	193	96	5	ab36d684bde8fe77d11a5188425135328052c58b
ToppCell	facs-Kidney-nan-3m-Endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ARAP3 CYP26B1 PLXND1 POLA2	6.30e-05	194	96	5	5fa2dfca32cca4abfda0af90b83f2b2a826f9b6e
ToppCell	facs-Kidney-nan-3m-Endothelial-fenestrated_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ARAP3 CYP26B1 PLXND1 POLA2	6.30e-05	194	96	5	04df35246287815bdd28adaf885bdb98cf49524e
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteoblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	SDK2 COL11A2 APCDD1 CHPF LRRC15	6.30e-05	194	96	5	292ce9021678534c9eedb367b9772a9d976208a8
ToppCell	facs-Kidney-nan-3m-Endothelial-Pecam____fenestrated_capillary_endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ARAP3 CYP26B1 PLXND1 POLA2	6.30e-05	194	96	5	90928d6c96c6304ae35dcc0275f7889de93da100
ToppCell	Smart-seq2-thymus_(Smart-seq2)-myeloid-myeloid_monocytic\|thymus_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PNPLA2 NBEAL2 MYO1F IL17RA SHKBP1	6.45e-05	195	96	5	ae98215b7b7f22f1aca690920ce6092dc4a3c7db
ToppCell	Smart-seq2-thymus_(Smart-seq2)-myeloid-myeloid_monocytic-monocyte\|thymus_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PNPLA2 NBEAL2 MYO1F IL17RA SHKBP1	6.45e-05	195	96	5	6fcab7aa4db958ccad0300adea9aaae52ace5bff
ToppCell	(6)_Endothelial_cells-(6)_Endothelial-B_(Artery)\|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	PLLP CYP26B1 TUSC3 PGRMC2 GATA5	6.61e-05	196	96	5	f540cf17b4405a6dd38d2b6123e6541d0aac889e
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLT4 CYP26B1 GATA5 PLXND1 MAP3K6	6.61e-05	196	96	5	65d882c6e7f6d5778b8a5fd4fdaf012e1b9f6100
ToppCell	10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-osteoblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	SDK2 COL11A2 APCDD1 CHPF LRRC15	6.61e-05	196	96	5	760885dc608c82768fe0decd63ed9fda8315f453
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FANCC FLT4 ARAP3 PLXND1 GAA	6.77e-05	197	96	5	789c97ca9d1e28df3353140046047f11fbccc1d0
ToppCell	B_cells-Plasmablasts\|B_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	FNDC3B ACADVL PGRMC2 EIF2AK4 CHPF	6.93e-05	198	96	5	c6cab47885be74a64351f843a741dea6d911bde4
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PLLP APCDD1 UMODL1 TUSC3 GABRQ	6.93e-05	198	96	5	02d0d8a212e09c0962ab1dae6a885d26d357f66a
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Radial_glial-RGCs_3\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	APCDD1 PXMP2 BARD1 PAWR POLA2	7.10e-05	199	96	5	79d87e2b0adeff2d33c3b699afe7211fddc4f285
ToppCell	PBMC-Control-cDC_0\|Control / Compartment, Disease Groups and Clusters	MYO1G NBEAL2 MYO1F IL17RA PLXND1	7.10e-05	199	96	5	ebf03979ef56e978d72db475bb635b43b9cbe402
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLT4 ARAP3 CYP26B1 PLXND1 MAP3K6	7.10e-05	199	96	5	e6715288a586631676722f2323f0d833431161cf
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FNDC3B SDK2 PAPPA SDK1 LRRC15	7.10e-05	199	96	5	8b86c69aaf60feff53aa782559cfece7342a23de
ToppCell	COVID-19-kidney-Glomerular_EC\|kidney / Disease (COVID-19 only), tissue and cell type	FLT4 ARAP3 CYP26B1 GATA5 PLXND1	7.10e-05	199	96	5	fffd2f9042b55531dac4e5b463b5cee80402e7bb
ToppCell	Tracheal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CYP26B1 APCDD1 PAPPA LTBP2 LRRC15	7.27e-05	200	96	5	8ab0051544ea32eb8b3f7f8ba7582deaf8bf26c0
ToppCell	Influenza\|World / Disease, condition lineage and cell class	MYO1G NBEAL2 MYO1F IL17RA SHKBP1	7.27e-05	200	96	5	df996c35907a1c9194b9e2ca30e81f520ca067f0
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLT4 ARAP3 CYP26B1 PLXND1 MAP3K6	7.27e-05	200	96	5	ced14d83222dbebca85c40540e76824e683354f3
ToppCell	Myeloid-C_(Cd16+_Monocyte)\|World / shred on cell class and cell subclass (v4)	MYO1G S1PR5 MYO1F IL17RA	1.55e-04	125	96	4	c73a77340e79f73fd1f900724e82a94d82e6b1bf
ToppCell	Globus_pallidus\|World / BrainAtlas - Mouse McCarroll V32	COL11A2 SZT2 GABRQ SHKBP1	1.60e-04	126	96	4	44b63f945d5bedf1a2ca1810e7e100276ea9dd89
ToppCell	390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	FNDC3B TAF1C MYO1F	1.82e-04	51	96	3	d43b0813f7c456f8fff77197fbbaef2f4d160563
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_ALM_Nxph2_Sla\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ERFE SDK2 CYP26B1 IL17RA	2.02e-04	134	96	4	6d97fa07f55ae20c17b9d5262e893957cccc6dba
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Penk_Col27a1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ARAP3 PAPPA PAWR	2.67e-04	58	96	3	ee9038695d11a428dc222962721bfdf11dd6954f
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Slc17a8\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PAPPA LRRC15 GP5	2.95e-04	60	96	3	40f29dfdbb17d39d8e6bb69dc5066fca3cd03308
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Slc17a8-Inhibitory_Neuron.Gad1Gad2Slc17a8_Sst.Ncam2_(Interneuron,__GABA/Glutamate_co-releasing?)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PAPPA LRRC15 GP5	2.95e-04	60	96	3	3a58f7a8e3d8a544286b7a3fe62efac8a0a0bb11
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Slc17a8-Inhibitory_Neuron.Gad1Gad2Slc17a8_Sst.Ncam2_(Interneuron,__GABA/Glutamate_co-releasing?)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PAPPA LRRC15 GP5	2.95e-04	60	96	3	ce13bbda7d105e1cb421790fb50d3b55ba2ed09a
ToppCell	P03-Hematopoietic-Immune-immune_cell_unspecified\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MYO1G S1PR5 MYO1F GP5	3.03e-04	149	96	4	43d756f81d532b5c7f2306e6af9d072d496cbc8e
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_C\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	S1PR5 MYO1F LTBP2 SSPOP	3.03e-04	149	96	4	95b21d67d6c335330a508f78d5cc074fdaf92275
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors-Progenitor\|bone_marrow / Manually curated celltypes from each tissue	SDK2 UMODL1 ZNF667 PAWR	3.03e-04	149	96	4	078e1e5765e476ba85c23fb8f6892b6698cbcbdb
ToppCell	P03-Hematopoietic-Immune\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MYO1G S1PR5 MYO1F GP5	3.03e-04	149	96	4	1c5a2572741c47246d455c865e8e1677c9f49598
ToppCell	356C-Fibroblasts-Fibroblast-H-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	PLEKHG6 IP6K1 HTRA4 MYO15A	3.19e-04	151	96	4	2dc132895609e4efe17954e31f53d9c1ccf256ef
ToppCell	356C-Fibroblasts-Fibroblast-H\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	PLEKHG6 IP6K1 HTRA4 MYO15A	3.19e-04	151	96	4	22afd8201eff8471da3456be065f2790de5e4bfe
ToppCell	droplet-Lung-nan-3m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G S1PR5 MYO1F IL17RA	3.35e-04	153	96	4	6dcab3d50ab50051955204dc4e4a64c1ca855bcd
ToppCell	droplet-Lung-nan-3m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G S1PR5 MYO1F IL17RA	3.35e-04	153	96	4	f6ef14d949107c08cb3690e26ec91e194cb43518
ToppCell	PND07-28-samps-Myeloid-Granulocyte-neutrophil__Lgals3-negative\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	MYO1G S1PR5 MYO1F IL17RA	3.61e-04	156	96	4	166f7b1220eaf8e1149dde260dd85a094855c54f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	S1PR5 FLT4 ARAP3 CHPF	3.61e-04	156	96	4	ea9223bb6450b22df11efa1705ab72dab005244a
ToppCell	PND07-28-samps-Myeloid-Granulocyte\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	MYO1G S1PR5 MYO1F IL17RA	3.61e-04	156	96	4	5e1c5a7c9293b886920739cf766521df7f69726c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	S1PR5 FLT4 ARAP3 CHPF	3.61e-04	156	96	4	586b5509074c4cc359e9e31a968c2ded71c994ca
ToppCell	facs-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYO1G S1PR5 MYO1F IL17RA	3.78e-04	158	96	4	121d63b8e2e37107467b170e5b2c798a7dbf6325
ToppCell	facs-Lung-Endomucin-24m-Myeloid\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G S1PR5 MYO1F IL17RA	3.87e-04	159	96	4	886cbaef39a3517514a3896b6b960d01a3af043d
ToppCell	facs-Lung-18m-Hematologic-myeloid-non-classical_monocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYO1G S1PR5 MYO1F IL17RA	3.97e-04	160	96	4	bc4a93dc5f37829799c37877e751ff3bc122e4ab
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G S1PR5 MYO1F IL17RA	3.97e-04	160	96	4	2020b6defbaf5b5db12af37f0103ac028a8ca76e
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G S1PR5 MYO1F IL17RA	3.97e-04	160	96	4	af7cf0dc5fe7c02f7d6c436f6dde766c79ff0eae
ToppCell	facs-Skin-Anagen-3m-Epithelial-inner_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G NCAN CPA2 GP5	4.06e-04	161	96	4	8d2987271da52fd8353557ac6faa4f7a4be0ed2a
ToppCell	E16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYO1G KLHL10 MYO1F MYO15A	4.06e-04	161	96	4	5a8698790f9aba796dd2b64af419055c60bd7de8
ToppCell	facs-Lung-EPCAM-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G S1PR5 MYO1F IL17RA	4.16e-04	162	96	4	484ea4ac40de672dcbd2583a52cb7f385c918814
ToppCell	facs-Lung-nan-3m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G S1PR5 MYO1F IL17RA	4.16e-04	162	96	4	3fd6aaf0fbaffc7ab38aa25e46c37ef511e1e704
ToppCell	facs-Lung-nan-3m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G S1PR5 MYO1F IL17RA	4.16e-04	162	96	4	8134f73eb76693f4f1845f643042fdc1e81c274c
ToppCell	facs-Lung-EPCAM-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G S1PR5 MYO1F IL17RA	4.16e-04	162	96	4	bba144ac5332bab9eba2ccf599703c781a7f88f1
ToppCell	facs-Lung-Endomucin-24m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G S1PR5 MYO1F IL17RA	4.26e-04	163	96	4	04152557aae230e9587fcc16cbabf1247cc5b419
ToppCell	facs-Lung-Endomucin-24m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G S1PR5 MYO1F IL17RA	4.26e-04	163	96	4	0644eb8a66d4e944063125c423de66d2393388b1
ToppCell	facs-Lung-3m-Hematologic-myeloid-non-classical_monocyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYO1G S1PR5 MYO1F IL17RA	4.26e-04	163	96	4	bbbc3f0ce2616d07136f69ce682ba1d3790711d9
ToppCell	facs-Lung-EPCAM-24m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G S1PR5 MYO1F IL17RA	4.36e-04	164	96	4	15d52666e5150e7c34b1f641a937fb2d5e8aaf8a
ToppCell	facs-Lung-EPCAM-24m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G S1PR5 MYO1F IL17RA	4.36e-04	164	96	4	d622f0d8d8bad48dfdf160ec63c545df192637a9
ToppCell	facs-Lung-3m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYO1G S1PR5 MYO1F IL17RA	4.36e-04	164	96	4	11dfd84f5fb90de330858e1e852848832734e004
ToppCell	tumor_Lung-T/NK_cells-Cytotoxic_CD8+_T\|T/NK_cells / Location, Cell class and cell subclass	MYO1G S1PR5 MYO1F IL17RD	4.36e-04	164	96	4	60fe6bb86afaebd92590135f08f5434ce0d8d73c
ToppCell	facs-Lung-nan-3m-Myeloid\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G S1PR5 MYO1F IL17RA	4.46e-04	165	96	4	720649f330382ea2a68c64a5344160a048afb8f1
ToppCell	droplet-Lung-LUNG-1m-Myeloid-intermediate_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G S1PR5 MYO1F IL17RA	4.56e-04	166	96	4	dd5944101ef58a9a29aa3eb5c17690119572b8f1
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Intermediate_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G S1PR5 MYO1F IL17RA	4.56e-04	166	96	4	8e5e8de51b4dacdadaa5a08279df30b5c7ed3628
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPA2 PAWR IL17RD	4.65e-04	70	96	3	26178ee967d647224d93c7a6380f2d15d8fcfb8f
Disease	mean corpuscular hemoglobin concentration	ERFE FNDC3B PLLP BRIP1 CYP26B1 NCAN IREB2 EIF2AK4 MYO15A TERT ABCA7 VPS13B GAA	3.39e-05	1105	91	13	EFO_0004528
Disease	porphyria (implicated_via_orthology)	ACO1 IREB2	9.35e-05	5	91	2	DOID:13268 (implicated_via_orthology)
Disease	Milroy Disease	CELSR1 FLT4	9.35e-05	5	91	2	C1704423
Disease	Hypotrichosis simplex	APCDD1 LSS	1.96e-04	7	91	2	C1854310
Disease	hearing impairment	FANCC COL11A2 MYO15A USH2A	2.45e-04	98	91	4	C1384666
Disease	Malignant Head and Neck Neoplasm	FANCC CYLD BRIP1	3.43e-04	44	91	3	C0278996
Disease	obesity (implicated_via_orthology)	PNPLA2 SDK2 WNT1 PLXND1 SDK1	5.48e-04	215	91	5	DOID:9970 (implicated_via_orthology)
Disease	Oligospermia	PIWIL3 TPCN1	6.08e-04	12	91	2	C0028960
Disease	Myeloproliferative disease	GSKIP TERT	6.08e-04	12	91	2	C0027022
Disease	heart rate	FNDC3B PNPLA2 CELSR1 ARAP3 UMODL1	6.73e-04	225	91	5	EFO_0004326
Disease	Astigmatism	MYO1G TUSC3 PLCL1 LNX1	6.94e-04	129	91	4	HP_0000483
Disease	Fanconi anemia	FANCC BRIP1	8.36e-04	14	91	2	cv:C0015625
Disease	central nervous system cancer, glioblastoma multiforme	TERT SLC16A8	8.36e-04	14	91	2	EFO_0000326, EFO_0000519
Disease	Hereditary Breast and Ovarian Cancer Syndrome	BRIP1 BARD1	8.36e-04	14	91	2	C0677776
Disease	lifestyle measurement, anxiety disorder measurement	TUSC3 CSMD2 USH2A SDK1	8.69e-04	137	91	4	EFO_0007795, EFO_0010724
Disease	mean arterial pressure	ARAP3 PCNX3 SZT2 IP6K1 EIF2AK4 LNX1 TERT	9.04e-04	499	91	7	EFO_0006340
Disease	Tetralogy of Fallot	FLT4 GATA5	1.10e-03	16	91	2	C0039685
Disease	Glycogen storage disease	PHKA2 GAA	1.24e-03	17	91	2	cv:C0017919
Disease	Bone marrow hypocellularity	FANCC BRIP1	1.39e-03	18	91	2	C1855710
Disease	BREAST CANCER	BRIP1 BARD1	1.90e-03	21	91	2	114480
Disease	Nonsyndromic Deafness	COL11A2 MYO1F MYO15A	2.03e-03	81	91	3	C3711374
Disease	functional brain measurement	ACO1 PXMP2 IL17RD	2.11e-03	82	91	3	EFO_0007849
Disease	sphingomyelin 24:1 measurement	CELSR1 TUSC3	2.28e-03	23	91	2	EFO_0010398
Disease	serum albumin measurement	FLT4 WDR81 IP6K1 EIF2AK4 LNX1 TERT ITIH1	2.39e-03	592	91	7	EFO_0004535
Disease	Fanconi Anemia	FANCC BRIP1	2.69e-03	25	91	2	C0015625
Disease	response to venlafaxine	ANGEL1 CSMD2	2.69e-03	25	91	2	EFO_0006328
Disease	atrophic macular degeneration	BARD1 PLCL1	2.69e-03	25	91	2	EFO_1001492
Disease	Pancytopenia	FANCC BRIP1	2.91e-03	26	91	2	C0030312
Disease	Acute monocytic leukemia	FANCC BRIP1	2.91e-03	26	91	2	C0023465
Disease	osteoarthritis, hip	BRIP1 LTBP2 ITIH1	2.92e-03	92	91	3	EFO_1000786

Protein segments in the cluster

Peptide	Gene	Start	Entry
PRRGGSNVVGYDRNN	UMODL1	611	Q5DID0
IARNSPAARYLTNRG	ACO1	686	P21399
LTNRGLTPREFNSYG	ACO1	696	P21399
LTPREFNSYGSRRGN	ACO1	701	P21399
NYSRGLGPRVRLFVF	LINC00479	96	Q96M42
DNYRRPTSAQGRLEG	ENKD1	21	Q9H0I2
PNSIYFGLDSRGRAQ	ARAP3	156	Q8WWN8
YGASRNAVNIFGLRP	BARD1	516	Q99728
GIPANGLRLGNDFRY	CSMD2	2956	Q7Z408
LAAGGRYDLLIPQFR	EIF2AK4	1346	Q9P2K8
LRDTGRYGFLLPARQ	CPA2	381	P48052
DSPINANLRYRVLGG	CELSR1	381	Q9NYQ6
FSPALQGRLRAAYEG	CDAN1	401	Q8IWY9
RVLSGANPRAGLYLQ	ABCA7	516	Q8IZY2
RSRDYNGRNQGGYDR	RBM3	131	P98179
RSGFPRYNRDANVSG	PAWR	246	Q96IZ0
GIQYGDAALRQLRSP	RAB4A	191	P20338
LRGTRPYNQRAAASF	PLLP	131	Q9Y342
LTNRGLTPREFNSYG	IREB2	771	P48200
LTPREFNSYGARRGN	IREB2	776	P48200
LYFERRRPLANGLAA	SLC16A8	136	O95907
GLRRPTGLFEGQRNY	PGM5	26	Q15124
GRELPRLRDYFSNPG	RELCH	121	Q9P260
GYRDGLRFLQRNGLL	PNPLA2	241	Q96AD5
DNYLRSPGGRQLRAA	IL17RA	556	Q96F46
PGQHTRQGSRRNYFR	IL17RD	521	Q8NFM7
RNAIRGRFPLYNLGF	ITIH1	421	P19827
RQYQQPFRGGRPEAL	MYO15A	2581	Q9UKN7
ARAGPGEQGLLNAYR	FRMD8	221	Q9BZ67
VLSRYDVRLRPNFGG	GABRQ	66	Q9UN88
VDLPFSGYRRGIQAR	CYP26B1	226	Q9NR63
ARAGPGEQSLLNAYR	FRMD8P1	221	Q9BZ68
FHYTFALNRRNRPGD	MAP3K6	316	O95382
QPFDYSPIRFRARNG	PER2	391	O15055
EQRRGAGGYQPLDRR	PCNX3	271	Q9H6A9
EAQRGSRFRLDYLPN	PLXND1	1161	Q9Y4D7
YDGSRNPRILLAVNG	PGRMC2	111	O15173
FRRGPGLNLTSGQYR	ERFE	236	Q4G0M1
LGRFSQLYPERALAG	LSS	716	P48449
LGRPVRFLYEDQTGR	COL11A2	116	P13942
FRSRNNGQAPDAYRP	LNX1	361	Q8TBB1
GRPRRLQRYLQSGEF	GARIN5A	91	Q6IPT2
ALYFSGRGEQLRLRA	PAPPA	96	Q13219
LNPFIYSRNSAGLRR	GPR75	371	O95800
DDRFRNNPSRYISGL	BRIP1	846	Q9BX63
RRLQQYVPFARGSGQ	PLEKHG6	51	Q3KR16
RDGSAYQGALLPREQ	GATA5	111	Q9BWX5
PAYREAFGNALLQRL	GSKIP	116	Q9P0R6
GTRSAGPLRRNYNFI	HTRA4	156	P83105
YAARRDNFPGLALRD	KLHL10	581	Q6JEL2
GNLLPGTVYRFRVRA	FNDC3B	731	Q53EP0
LAFYYGPRDGRQQRA	FANCC	426	Q00597
ARGRYLLFNGQRPSD	APCDD1	431	Q8J025
PIDGFNGRFGYRRNT	C17orf98	121	A8MV24
NGRFGYRRNTPALRQ	C17orf98	126	A8MV24
RPYDEGLRRGVFITN	GAA	456	P10253
GRYEPAGGDANRLRR	LTBP2	41	Q14767
AYQFRPDGASLNRRP	FBXW4	141	P57775
EQNGDYGRGRRTLFR	LARP4	436	Q71RC2
GRGLSIEGFRNALYQ	IP6K1	281	Q92551
PAAAFRNLSRLRYLG	GP5	306	P40197
PGNRNRSELFYTLNG	CYLD	346	Q9NQC7
SRFLERQTYNIPGGR	HELZ2	2136	Q9BYK8
GRARRRESYQQEAPG	PIWIL3	11	Q7Z3Z3
LRYRLAGLPGEYQQR	SDK1	806	Q7Z5N4
YEGLRGFTLRGINNP	SDK2	1546	Q58EX2
RGARYQPGAGLRADA	S1PR5	26	Q9H228
RRLDGAINRVPVGFY	PHKA2	1071	P46019
PRAQAGSGYNFLSLR	RTP2	186	Q5QGT7
RQNRLDSPLSNRYAG	SYDE2	1076	Q5VT97
PFRRDLQAYAGRQAS	SZT2	1211	Q5T011
SGLNRQFLFRRLDPF	USH2A	4111	O75445
QQRYRHQGPASRGAR	SSPOP	4386	A2VEC9
QPCGRFLRAYREGAL	TRADD	81	Q15628
RITPGAFRNLGSLRY	LRRC15	91	Q8TF66
YLSNRQRRFSILGGP	TAF1C	166	Q15572
GIGYDFRRPLAQLRE	NBEAL2	1961	Q6ZNJ1
GVRSYGRRNPQELYD	NCAN	236	O14594
LGSRPRRYLLTGQAN	SHKBP1	556	Q8TBC3
VEQLGSALRFRPGYN	SHISA5	86	Q8N114
RQILQADGLRGFYRG	SLC25A44	171	Q96H78
QVGGTFARLYLRRPA	POLA2	566	Q14181
ARRPYAGGAAQLALD	ACADVL	36	P49748
YFRPGLELLNRDNVG	ANGEL1	351	Q9UNK9
QQLVNGYRRFDPARG	CHPF	446	Q8IZ52
NYRNLVSLGLSFRRP	ZNF667	46	Q5HYK9
QFRGPADINGYIRAL	PLCL1	421	Q15111
RQAGRRLRYLPTGSF	TUSC3	11	Q13454
DYRPLRGDGNQNGYR	RBMXL3	271	Q8N7X1
EAGLGALPRRALAQY	PXMP2	11	Q9NR77
LNGDERSGSNYRRIP	TRO	416	Q12816
RPERGARGGQVFYNS	FLT4	1321	P35916
SQRRPAGISYRQFEG	TPCN1	351	Q9ULQ1
LSALSRGQAYFLRPG	VWA5B2	491	Q8N398
LRDRFDGASRVLYGN	WNT1	246	P04628
RQARRLYVGNIPFGI	U2AF2	146	P26368
YQRALNLGILRDPGS	VPS13B	1606	Q7Z7G8
NYERARRPGLLGASV	TERT	666	O14746
LNRLAGRRQGDPNYH	WDR81	366	Q562E7
RRNSINRNFVGDYLG	MYO1F	731	O00160
AGFASRQPYSRFLLR	MYO1G	636	B0I1T2