Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

DENND4A SIPA1 IQGAP2 SLC38A9 DENND3 IQSEC2 FARP2

1.48e-04507467GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

DENND4A SIPA1 IQGAP2 SLC38A9 DENND3 IQSEC2 FARP2

1.48e-04507467GO:0030695
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

DENND4A SLC38A9 DENND3 IQSEC2 FARP2

1.85e-04231465GO:0005085
DomainSpeedy

SPDYE1 SPDYE6

3.22e-0411462IPR020984
DomainSpy1

SPDYE1 SPDYE6

3.22e-0411462PF11357
DomainWWE

PARP11 ZC3HAV1

3.86e-0412462PS50918
DomainWWE-dom

PARP11 ZC3HAV1

3.86e-0412462IPR004170
DomainWWE

PARP11 ZC3HAV1

3.86e-0412462PF02825
DomainFA

EPB41L4A FARP2

4.55e-0413462SM01195
DomainFERM-adjacent

EPB41L4A FARP2

4.55e-0413462IPR014847
DomainFA

EPB41L4A FARP2

4.55e-0413462PF08736
DomainZINC_FINGER_C2H2_2

ZNF267 ZNF12 ZNF705A ZFAT SUZ12 ZNF333 ZNF296 GLIS2

5.45e-04775468PS50157
DomainZINC_FINGER_C2H2_1

ZNF267 ZNF12 ZNF705A ZFAT SUZ12 ZNF333 ZNF296 GLIS2

5.55e-04777468PS00028
DomainuDENN

DENND4A DENND3

6.11e-0415462PF03456
DomainZnf_C2H2-like

ZNF267 ZNF12 ZNF705A ZFAT SUZ12 ZNF333 ZNF296 GLIS2

6.51e-04796468IPR015880
DomainDENN

DENND4A DENND3

6.97e-0416462PF02141
DomainUDENN

DENND4A DENND3

6.97e-0416462PS50946
DomainDDENN

DENND4A DENND3

6.97e-0416462PS50947
DomaindDENN_dom

DENND4A DENND3

6.97e-0416462IPR005112
DomainuDENN_dom

DENND4A DENND3

6.97e-0416462IPR005113
DomaindDENN

DENND4A DENND3

6.97e-0416462PF03455
DomainDENN

DENND4A DENND3

6.97e-0416462SM00799
DomainDENN

DENND4A DENND3

6.97e-0416462PS50211
DomainDENN_dom

DENND4A DENND3

6.97e-0416462IPR001194
DomaindDENN

DENND4A DENND3

6.97e-0416462SM00801
DomainIQ

ASPM IQGAP2 IQSEC2

7.11e-0471463PF00612
DomainZnF_C2H2

ZNF267 ZNF12 ZNF705A ZFAT SUZ12 ZNF333 ZNF296 GLIS2

7.18e-04808468SM00355
DomainPoly(ADP-ribose)pol_cat_dom

PARP11 ZC3HAV1

7.88e-0417462IPR012317
DomainPARP_CATALYTIC

PARP11 ZC3HAV1

7.88e-0417462PS51059
DomainPARP

PARP11 ZC3HAV1

7.88e-0417462PF00644
Domain-

PARP11 ZC3HAV1

7.88e-04174623.90.228.10
DomainEz/rad/moesin-like

EPB41L4A FARP2

1.21e-0321462IPR000798
Domain-

ZNF267 ZNF12 ZNF705A ZFAT ZNF333 ZNF296 GLIS2

1.27e-036794673.30.160.60
DomainIQ_motif_EF-hand-BS

ASPM IQGAP2 IQSEC2

1.41e-0390463IPR000048
Domainzf-C2H2

ZNF267 ZNF12 ZNF705A ZFAT ZNF333 ZNF296 GLIS2

1.43e-03693467PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF267 ZNF12 ZNF705A ZFAT ZNF333 ZNF296 GLIS2

1.44e-03694467IPR013087
DomainIQ

ASPM IQGAP2 IQSEC2

1.55e-0393463PS50096
DomainWGR_domain

PARP11 ZC3HAV1

1.58e-0324462IPR008893
DomainFERM_CS

EPB41L4A FARP2

1.58e-0324462IPR019747
DomainFERM_C

EPB41L4A FARP2

1.86e-0326462PF09380
DomainFERM_C

EPB41L4A FARP2

2.00e-0327462SM01196
DomainFERM_PH-like_C

EPB41L4A FARP2

2.00e-0327462IPR018980
DomainFERM_N

EPB41L4A FARP2

2.98e-0333462IPR018979
DomainFERM_N

EPB41L4A FARP2

2.98e-0333462PF09379
DomainZnf_C2H2

ZNF267 ZNF12 ZNF705A ZFAT ZNF333 ZNF296 GLIS2

3.32e-03805467IPR007087
DomainFERM_M

EPB41L4A FARP2

5.73e-0346462PF00373
DomainFERM_central

EPB41L4A FARP2

6.48e-0349462IPR019748
DomainFERM_domain

EPB41L4A FARP2

6.48e-0349462IPR000299
Domain-

EPB41L4A FARP2

6.48e-03494621.20.80.10
DomainFERM_1

EPB41L4A FARP2

6.74e-0350462PS00660
DomainFERM_2

EPB41L4A FARP2

6.74e-0350462PS00661
DomainBand_41_domain

EPB41L4A FARP2

6.74e-0350462IPR019749
DomainB41

EPB41L4A FARP2

6.74e-0350462SM00295
DomainFERM/acyl-CoA-bd_prot_3-hlx

EPB41L4A FARP2

6.74e-0350462IPR014352
DomainFERM_3

EPB41L4A FARP2

6.74e-0350462PS50057
DomainCH

ASPM IQGAP2

1.12e-0265462SM00033
DomainKRAB

ZNF267 ZNF12 ZNF705A ZNF333

1.15e-02358464PS50805
DomainKRAB

ZNF267 ZNF12 ZNF705A ZNF333

1.15e-02358464PF01352
Pubmed

Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms.

FSIP2 KDM4C

5.13e-06346222072270
Pubmed

Mediator CDK subunits are platforms for interactions with various chromatin regulatory complexes.

CDK8 SUZ12

3.58e-05746222668559
Pubmed

Epigenetic modification of histone 3 lysine 27: mediator subunit MED25 is required for the dissociation of polycomb repressive complex 2 from the promoter of cytochrome P450 2C9.

SUZ12 HNF4A

3.58e-05746225391650
Pubmed

Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.

OTOF UNC13A

4.77e-05846225609709
Pubmed

Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.

SPDYE1 SPDYE6

6.12e-05946236272447
Pubmed

Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.

SPDYE1 SPDYE6

1.32e-041346215611625
Pubmed

Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.

CDK8 STK35

1.54e-041446224811271
Pubmed

Family-wide analysis of poly(ADP-ribose) polymerase activity.

PARP11 ZC3HAV1

2.03e-041646225043379
Pubmed

Characterization of a new family of cyclin-dependent kinase activators.

SPDYE1 SPDYE6

2.30e-041746215574121
Pubmed

Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.

ZNF267 ZNF12

3.54e-04214627865130
Pubmed

Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.

KDM4C FARP2

3.54e-042146225340873
Pubmed

Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin.

ZNF296 KDM4C

3.89e-042246228963472
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

FSIP2 DENND4A EDC3 IQSEC2 TRAK1 ZC3HAV1

9.11e-0486146636931259
Pubmed

Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model.

HNF4A GLIS2

1.05e-033646233737325
Pubmed

Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.

DENND4A DENND3

1.11e-033746220937701
Pubmed

Effects of glucokinase haploinsufficiency on the pancreatic β-cell mass and function of long-term high-fat, high-sucrose diet-fed mice.

PCDH15 EPB41L4A

1.11e-033746239305123
Pubmed

Defining the molecular character of the developing and adult kidney podocyte.

IQGAP2 MTSS1

1.23e-033946221931791
CytobandEnsembl 112 genes in cytogenetic band chr2p23

CAPN13 ADGRF3 OTOF

4.59e-04149463chr2p23
Cytoband3p22.1

ANO10 TRAK1

7.48e-04404623p22.1
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF267 ZNF12 ZNF705A ZFAT SUZ12 ZNF333 ZNF296 GLIS2

8.26e-0571837828
GeneFamilySpeedy/RINGO cell cycle regulator family

SPDYE1 SPDYE6

2.66e-0412372756
GeneFamilyZinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases

PARP11 ZC3HAV1

5.44e-0417372684
GeneFamilyGuanylate cyclase receptors|DENN/MADD domain containing

DENND4A DENND3

1.19e-0325372504
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

EPB41L4A FARP2

4.69e-03503721293
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CAPN13 EPB41L4A DENND3 VEPH1 SEMA3B

1.72e-06195465a71ba5e4043e2d35a45a2c60a96b087e31832345
ToppCellsevere-unassigned|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CDK8 ASPM SUZ12 IQGAP2 DENND3

1.81e-0619746570704b149b2820b8601d2495b7cd9cbe91eda262
ToppCelldroplet-Trachea-3m-Hematologic-myeloid-granulocyte-granulocyte_l34|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DENND4A OTOF GPR132 TLR8

2.71e-0516846484977db9d71e59208727885320cc18d80d064380
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPB41L4A OTOF VEPH1 SEMA3B

2.97e-051724643f784aed340b50ddbec3f7dc0a5279180d38a2bb
ToppCellfacs-Lung-EPCAM-24m-Lymphocytic-lymphocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PARP11 EPB41L4A GPR132 ZC3HAV1

3.04e-051734646e92983d9f8a2a37f23e60a0d5bb1738217897bc
ToppCellfacs-Lung-EPCAM-24m-Lymphocytic-Alox5+_Lymphocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PARP11 EPB41L4A GPR132 ZC3HAV1

3.04e-051734644c788c1dad1da495b3b5c10f95e779848dfe85dc
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PARD6G TACR3 IQGAP2 MTSS1

3.32e-051774644d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PARD6G TACR3 IQGAP2 MTSS1

3.39e-05178464edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF12 PARD6G DENND4A DENND3

3.95e-05185464bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

EPB41L4A DENND3 VEPH1 SEMA3B

4.11e-051874644ae7465174e0295d2c3b614b321a3b2f514dd22a
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

EPB41L4A DENND3 VEPH1 SEMA3B

4.20e-05188464eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

PCDH15 DENND4A MTSS1 FARP2

4.65e-0519346408696a99309f5b088692ddac8cca35413b5e810d
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DLGAP2 SLITRK3 OTOF UNC13A

4.65e-05193464be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DLGAP2 SLITRK3 OTOF UNC13A

4.65e-051934640c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DLGAP2 SLITRK3 OTOF UNC13A

4.65e-051934648689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DENND4A TRAK1 MTSS1 FARP2

4.75e-05194464d852aebf7a763b9a776c4570711f0c759f591910
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DENND4A TRAK1 MTSS1 FARP2

4.84e-05195464481989d2e5bd2582da3d86b0155c4d6615317067
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DENND4A TRAK1 MTSS1 FARP2

4.84e-051954646108a27523d1b93a7fbe35cb95704a5ad9071e3c
ToppCellBAL-Mild-cDC_10|Mild / Compartment, Disease Groups and Clusters

DENND4A ZNF296 GPR132 MTSS1

5.04e-05197464c0550d41dd5619b369b590f3d6a61154dd7b2cab
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CAPN13 EPB41L4A DENND3 SEMA3B

5.04e-051974648d5097898dd01cedb04cb694cb480c931e08462c
DiseasePituitary Gland Adenoma

CDK8 PCDH15

3.25e-056442EFO_1000478
Diseasealcohol use disorder (implicated_via_orthology)

ADGRF3 HNF4A KDM4C UNC13A

2.04e-04195444DOID:1574 (implicated_via_orthology)
DiseaseDeaf Mutism

PCDH15 OTOF

4.06e-0420442C4082305
DiseaseDeafness, Acquired

PCDH15 OTOF

4.06e-0420442C0751068
DiseaseHearing Loss, Extreme

PCDH15 OTOF

4.06e-0420442C0086395
DiseaseComplete Hearing Loss

PCDH15 OTOF

4.06e-0420442C0581883
DiseasePrelingual Deafness

PCDH15 OTOF

4.06e-0420442C0011052
DiseaseBilateral Deafness

PCDH15 OTOF

4.06e-0420442C3665473
Diseasehearing impairment

CDK8 PCDH15 OTOF

4.26e-0498443C1384666
DiseaseDeafness

PCDH15 OTOF

6.38e-0425442C0011053
Diseasepyruvate measurement

PCDH15 CAPN13 DLGAP2 VEPH1

6.79e-04268444EFO_0010117
Diseaseresponse to vaccine

CDK8 PCDH15 STK35

8.07e-04122443EFO_0004645
Diseasefibrinogen measurement, tissue plasminogen activator measurement

HNF4A FARP2

2.07e-0345442EFO_0004623, EFO_0004791
Diseasefibrinogen measurement, plasminogen activator inhibitor 1 measurement

HNF4A FARP2

2.07e-0345442EFO_0004623, EFO_0004792
Diseaseunipolar depression, information processing speed, cognitive function measurement

PCDH15 DLGAP2

2.25e-0347442EFO_0003761, EFO_0004363, EFO_0008354
DiseaseNonsyndromic Hearing Loss and Deafness, Autosomal Recessive

PCDH15 OTOF

2.65e-0351442cv:CN043650

Protein segments in the cluster

PeptideGeneStartEntry
HNSLRIDLSMYRNNF

UNC13A

941

Q9UPW8
RNKISYFRHAALLNM

ADGRF3

801

Q8IZF5
KFRSRNQSYMRAVST

DLGAP2

506

Q9P1A6
SSNNKFRRNFTMTYH

CAPN13

436

Q6MZZ7
DTYMFHSFLKARLNR

DENND3

406

A2RUS2
AATLIQSFYRMHRAK

ASPM

2691

Q8IZT6
RSRDRSHQKFYNMMT

DENND4A

606

Q7Z401
KLHYFNARGRMESTR

GSTA1

6

P08263
TMRAFTYRTRQNFKG

ANO10

96

Q9NW15
YRMNKNFERLRSSAS

IQSEC2

361

Q5JU85
FHKLYSAAMTERNVR

FSIP2

1851

Q5CZC0
RSVRKNHMYSCRFSR

HNF4A

86

P41235
QSYRRMFQAKRPAST

MTSS1

556

O43312
NIRFNRSKSLAFHTM

VEPH1

441

Q14D04
ITKHRNTRYYSCRVM

KDM4C

886

Q9H3R0
MESLSQSKSFRRRHN

EDC3

146

Q96F86
NKRYSNSSDRFKHTR

GLIS2

271

Q9BZE0
MNRSFHKSQTLRFYD

PARD6G

1

Q9BYG4
QQRHLFRTYKSMFLA

PARP11

266

Q9NR21
HNMRRSYFKFQVIAT

PCDH15

1211

Q96QU1
RRYRLFANRSSIMRH

C14orf93

396

Q9H972
NMRQLKEFTSYFQRH

FARP2

626

O94887
HSTLMKDFRRNTYTN

CDK8

276

P49336
RYKHRYSGRTALQMS

EPB41L4A

316

Q9HCS5
ASAMNKRIHYYSRLT

SLC38A9

61

Q8NBW4
QLRAHMYQARSLFAA

OTOF

961

Q9HC10
AFTNHRIFRSIKQSM

GPR132

216

Q9UNW8
FRMATARKSYLSRLQ

IQGAP2

731

Q13576
RNSMRKLYTNSFLHL

SLITRK3

86

O94933
ARQFHAMATRTRQQY

SIPA1

521

Q96FS4
RFHPNRQSSMYTVTR

TACR3

391

P29371
RNKTMPNTTSRRYHS

TRAK1

351

Q9UPV9
YANSSSFQRHIRKRR

TLR8

441

Q9NR97
QRMSHGNKSSQLYLR

STK35

276

Q8TDR2
YATRSKSNLKAHMNR

ZFAT

916

Q9P243
YTNCFRLRRHKMTHT

ZNF705A

181

Q6ZN79
MQISSKRHQLYVASR

SEMA3B

491

Q13214
KHRFQLYRSMNSRAR

SPDYE6

336

P0CI01
TYMSHRNSRTNIKRK

SUZ12

116

Q15022
KSYARSSNLIMHQRV

ZNF267

471

Q14586
YRSMNPRARKNRSHI

SPDYE1

251

Q8NFV5
ITTNERMNARRYKHF

ZDHHC17

561

Q8IUH5
QAFKYSSNLRRHMRT

ZNF333

401

Q96JL9
SHRRNMAYRARSKSR

ZC3HAV1

236

Q7Z2W4
GKTFYLNSALMRHQR

ZNF12

471

P17014
YACAQSSKLNRHRRM

ZNF296

421

Q8WUU4