Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	promoter-specific chromatin binding	ZC3H4 CHD7 TAF1L DDX5	4.70e-05	83	48	4	GO:1990841
GeneOntologyMolecularFunction	cargo receptor activity	CTAGE9 MIA2 CTAGE1 CTAGE8	5.16e-05	85	48	4	GO:0038024
GeneOntologyMolecularFunction	RNA polymerase I core promoter sequence-specific DNA binding	SMARCA4 TBP	3.07e-04	11	48	2	GO:0001164
GeneOntologyMolecularFunction	core promoter sequence-specific DNA binding	SMARCA4 TAF1L TBP	3.13e-04	55	48	3	GO:0001046
GeneOntologyMolecularFunction	chromatin binding	WBP2 ZC3H4 GLI1 SREBF1 SMARCA4 CHD7 TAF1L DDX5	3.44e-04	739	48	8	GO:0003682
GeneOntologyMolecularFunction	transcription factor binding	WBP2 SREBF1 SMARCA4 PRKDC TAF1L MEIS2 DDX5 TBP	3.90e-04	753	48	8	GO:0008134
GeneOntologyMolecularFunction	RNA polymerase I transcription regulatory region sequence-specific DNA binding	SMARCA4 TBP	4.34e-04	13	48	2	GO:0001163
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	WBP2 SMARCA4 PRKDC TAF1L DDX5 TBP	4.68e-04	417	48	6	GO:0061629
GeneOntologyMolecularFunction	basal RNA polymerase II transcription machinery binding	RPRD2 TAF1L TBP	5.36e-04	66	48	3	GO:0001099
GeneOntologyMolecularFunction	basal transcription machinery binding	RPRD2 TAF1L TBP	5.36e-04	66	48	3	GO:0001098
GeneOntologyMolecularFunction	nuclear receptor binding	WBP2 SMARCA4 TAF1L DDX5	1.05e-03	187	48	4	GO:0016922
GeneOntologyMolecularFunction	RNA polymerase II core promoter sequence-specific DNA binding	TAF1L TBP	1.64e-03	25	48	2	GO:0000979
GeneOntologyMolecularFunction	RNA polymerase II general transcription initiation factor binding	TAF1L TBP	1.91e-03	27	48	2	GO:0001091
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	WBP2 GLI1 SREBF1 SMARCA4 CHD7 DLX6 TAF1L MEIS2 SMAD5 TBP	2.12e-03	1459	48	10	GO:0000977
GeneOntologyMolecularFunction	lysine-acetylated histone binding	SMARCA4 TAF1L	2.36e-03	30	48	2	GO:0070577
GeneOntologyMolecularFunction	acetylation-dependent protein binding	SMARCA4 TAF1L	2.52e-03	31	48	2	GO:0140033
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	WBP2 GLI1 SREBF1 SMARCA4 CHD7 DLX6 MEIS2 SMAD5 TBP	2.54e-03	1244	48	9	GO:0000978
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	WBP2 SMARCA4 PRKDC TAF1L DDX5 TBP	2.59e-03	582	48	6	GO:0140297
GeneOntologyMolecularFunction	nuclear androgen receptor binding	SMARCA4 DDX5	2.85e-03	33	48	2	GO:0050681
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	WBP2 GLI1 SREBF1 SMARCA4 CHD7 DLX6 MEIS2 SMAD5 TBP	2.93e-03	1271	48	9	GO:0000987
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	SMARCA4 CHD7	3.57e-03	37	48	2	GO:0140658
GeneOntologyMolecularFunction	helicase activity	SMARCA4 CHD7 DDX5	6.48e-03	158	48	3	GO:0004386
GeneOntologyMolecularFunction	RNA polymerase II general transcription initiation factor activity	TAF1L TBP	6.95e-03	52	48	2	GO:0016251
GeneOntologyBiologicalProcess	vesicle cargo loading	CTAGE9 MIA2 CTAGE1 CTAGE8 CTAGE15 CTAGE6 CTAGE4	2.51e-12	36	50	7	GO:0035459
GeneOntologyBiologicalProcess	endoplasmic reticulum to Golgi vesicle-mediated transport	CTAGE9 MIA2 CTAGE1 CTAGE8 CTAGE15 CTAGE6 CTAGE4	1.07e-07	159	50	7	GO:0006888
GeneOntologyBiologicalProcess	triglyceride homeostasis	CTAGE9 MIA2 CTAGE1 CTAGE8	6.48e-06	50	50	4	GO:0070328
GeneOntologyBiologicalProcess	acylglycerol homeostasis	CTAGE9 MIA2 CTAGE1 CTAGE8	7.02e-06	51	50	4	GO:0055090
GeneOntologyBiologicalProcess	Golgi vesicle transport	CTAGE9 MIA2 CTAGE1 CTAGE8 CTAGE15 CTAGE6 CTAGE4	1.66e-05	339	50	7	GO:0048193
GeneOntologyBiologicalProcess	protein secretion	CTAGE9 MIA2 CTAGE1 CTAGE8 SREBF1 CTAGE15 CTAGE6 CTAGE4	1.85e-05	480	50	8	GO:0009306
GeneOntologyBiologicalProcess	establishment of protein localization to extracellular region	CTAGE9 MIA2 CTAGE1 CTAGE8 SREBF1 CTAGE15 CTAGE6 CTAGE4	1.93e-05	483	50	8	GO:0035592
GeneOntologyBiologicalProcess	protein localization to extracellular region	CTAGE9 MIA2 CTAGE1 CTAGE8 SREBF1 CTAGE15 CTAGE6 CTAGE4	2.14e-05	490	50	8	GO:0071692
GeneOntologyBiologicalProcess	response to progesterone	TXNIP WBP2 SREBF1	1.77e-04	45	50	3	GO:0032570
GeneOntologyBiologicalProcess	secretion by cell	CACNA1A CTAGE9 MIA2 CTAGE1 CTAGE8 SREBF1 CTAGE15 CHD7 CTAGE6 CTAGE4	1.99e-04	1064	50	10	GO:0032940
GeneOntologyBiologicalProcess	cholesterol homeostasis	CTAGE9 MIA2 CTAGE1 CTAGE8	2.31e-04	124	50	4	GO:0042632
GeneOntologyBiologicalProcess	sterol homeostasis	CTAGE9 MIA2 CTAGE1 CTAGE8	2.39e-04	125	50	4	GO:0055092
GeneOntologyBiologicalProcess	developmental growth	SEMA3F KMT2C TENM4 GLI1 SMARCA4 IST1 CHD7 PRKDC ALPI	3.01e-04	911	50	9	GO:0048589
GeneOntologyBiologicalProcess	RNA polymerase I preinitiation complex assembly	SMARCA4 TBP	3.12e-04	11	50	2	GO:0001188
GeneOntologyBiologicalProcess	mRNA transcription	SREBF1 DDX5 TBP	3.58e-04	57	50	3	GO:0009299
GeneOntologyBiologicalProcess	export from cell	CACNA1A CTAGE9 MIA2 CTAGE1 CTAGE8 SREBF1 CTAGE15 CHD7 CTAGE6 CTAGE4	3.80e-04	1153	50	10	GO:0140352
GeneOntologyBiologicalProcess	central nervous system development	CACNA1A SEMA3F NDNF TENM4 DBX1 GLI1 SMARCA4 CHD7 PRKDC MEIS2	5.10e-04	1197	50	10	GO:0007417
GeneOntologyCellularComponent	endoplasmic reticulum exit site	CTAGE9 MIA2 CTAGE1 CTAGE8 CTAGE15 CTAGE6 CTAGE4	8.47e-12	42	51	7	GO:0070971
GeneOntologyCellularComponent	chromatin	WBP2 CDK2AP2 DBX1 SREBF1 SMARCA4 IST1 CHD7 DLX6 PRKDC TAF1L MEIS2 SMAD5 TBP	4.00e-05	1480	51	13	GO:0000785
MousePheno	decreased circulating VLDL triglyceride level	CTAGE9 MIA2 CTAGE1 CTAGE8	2.16e-07	19	40	4	MP:0003976
MousePheno	decreased triglyceride level	CTAGE9 MIA2 CTAGE1 CTAGE8 SREBF1 CHD7 ITPRID2	5.12e-05	348	40	7	MP:0005318
MousePheno	abnormal triglyceride level	TXNIP CTAGE9 MIA2 CTAGE1 CTAGE8 SREBF1 CHD7 ITPRID2 ALPI	6.30e-05	639	40	9	MP:0000187
MousePheno	abnormal habenula morphology	SEMA3F CHD7	7.94e-05	5	40	2	MP:0004082
MousePheno	abnormal circulating triglyceride level	TXNIP CTAGE9 MIA2 CTAGE1 CTAGE8 SREBF1 CHD7 ALPI	8.84e-05	516	40	8	MP:0011969
MousePheno	decreased circulating triglyceride level	CTAGE9 MIA2 CTAGE1 CTAGE8 SREBF1 CHD7	1.20e-04	275	40	6	MP:0002644
Domain	BRK	SMARCA4 CHD7	8.46e-05	6	45	2	SM00592
Domain	BRK_domain	SMARCA4 CHD7	8.46e-05	6	45	2	IPR006576
Domain	BRK	SMARCA4 CHD7	8.46e-05	6	45	2	PF07533
Domain	GRAM	WBP2 NSMAF	1.27e-03	22	45	2	PF02893
Domain	GRAM	WBP2 NSMAF	1.27e-03	22	45	2	IPR004182
Domain	Bromodomain_CS	SMARCA4 TAF1L	1.78e-03	26	45	2	IPR018359
Domain	Helicase_C	SMARCA4 CHD7 DDX5	2.18e-03	107	45	3	PF00271
Domain	HELICc	SMARCA4 CHD7 DDX5	2.18e-03	107	45	3	SM00490
Domain	Helicase_C	SMARCA4 CHD7 DDX5	2.24e-03	108	45	3	IPR001650
Domain	HELICASE_CTER	SMARCA4 CHD7 DDX5	2.30e-03	109	45	3	PS51194
Domain	HELICASE_ATP_BIND_1	SMARCA4 CHD7 DDX5	2.30e-03	109	45	3	PS51192
Domain	DEXDc	SMARCA4 CHD7 DDX5	2.30e-03	109	45	3	SM00487
Domain	Helicase_ATP-bd	SMARCA4 CHD7 DDX5	2.36e-03	110	45	3	IPR014001
Domain	SNF2_N	SMARCA4 CHD7	2.69e-03	32	45	2	IPR000330
Domain	SNF2_N	SMARCA4 CHD7	2.69e-03	32	45	2	PF00176
Domain	BROMODOMAIN_1	SMARCA4 TAF1L	3.58e-03	37	45	2	PS00633
Domain	Bromodomain	SMARCA4 TAF1L	3.78e-03	38	45	2	PF00439
Domain	BROMODOMAIN_2	SMARCA4 TAF1L	4.38e-03	41	45	2	PS50014
Domain	BROMO	SMARCA4 TAF1L	4.60e-03	42	45	2	SM00297
Domain	Bromodomain	SMARCA4 TAF1L	4.60e-03	42	45	2	IPR001487
Domain	-	SMARCA4 TAF1L	4.60e-03	42	45	2	1.20.920.10
Pathway	REACTOME_CARGO_CONCENTRATION_IN_THE_ER	CTAGE9 MIA2 CTAGE1 CTAGE8	9.36e-07	36	30	4	MM15300
Pathway	BIOCARTA_HSWI_SNF_PATHWAY	SMARCA4 TBP	1.95e-04	10	30	2	MM1532
Pathway	BIOCARTA_HSWI_SNF_PATHWAY	SMARCA4 TBP	2.85e-04	12	30	2	M22006
Pubmed	Mea6 controls VLDL transport through the coordinated regulation of COPII assembly.	CTAGE9 MIA2 CTAGE1 CTAGE8	4.10e-12	4	51	4	27311593
Pubmed	MEA6 Deficiency Impairs Cerebellar Development and Motor Performance by Tethering Protein Trafficking.	CTAGE9 MIA2 CTAGE1 CTAGE8	4.10e-12	4	51	4	31244610
Pubmed	Reduced cholesterol and triglycerides in mice with a mutation in Mia2, a liver protein that localizes to ER exit sites.	CTAGE9 MIA2 CTAGE1 CTAGE8	4.10e-12	4	51	4	21807889
Pubmed	Deletion of Mea6 in Cerebellar Granule Cells Impairs Synaptic Development and Motor Performance.	CTAGE9 MIA2 CTAGE1 CTAGE8	4.10e-12	4	51	4	33718348
Pubmed	Specific expression and regulation of the new melanoma inhibitory activity-related gene MIA2 in hepatocytes.	CTAGE9 MIA2 CTAGE1 CTAGE8	4.10e-12	4	51	4	12586826
Pubmed	cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing.	CTAGE9 MIA2 CTAGE1 CTAGE4	2.05e-11	5	51	4	12839582
Pubmed	Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.	CTAGE9 MIA2 CTAGE1 CTAGE8	2.05e-11	5	51	4	18630941
Pubmed	Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.	CTAGE9 MIA2 CTAGE1 CTAGE8	2.05e-11	5	51	4	19131326
Pubmed	Characterization and expression pattern of the novel MIA homolog TANGO.	CTAGE9 MIA2 CTAGE1 CTAGE8	2.05e-11	5	51	4	15183315
Pubmed	Mea6/cTAGE5 cooperates with TRAPPC12 to regulate PTN secretion and white matter development.	CTAGE9 MIA2 CTAGE1 CTAGE8	2.05e-11	5	51	4	38439956
Pubmed	A tissue-specific atlas of mouse protein phosphorylation and expression.	CTAGE9 MIA2 CTAGE1 CTAGE8	2.05e-11	5	51	4	21183079
Pubmed	cTAGE5 deletion in pancreatic β cells impairs proinsulin trafficking and insulin biogenesis in mice.	CTAGE9 MIA2 CTAGE1 CTAGE8	1.43e-10	7	51	4	29133483
Pubmed	Misexpression of MIA disrupts lung morphogenesis and causes neonatal death.	CTAGE9 MIA2 CTAGE1 CTAGE8	5.14e-10	9	51	4	18342301
Pubmed	Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice.	CTAGE9 MIA2 CTAGE1 CTAGE8	2.90e-09	13	51	4	11839810
Pubmed	cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development.	CTAGE9 MIA2 CTAGE1 CTAGE8	5.53e-09	15	51	4	30224460
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	ZC3H4 YLPM1 SMARCA4 RPRD2 CHD7 PRKDC TAF1L DDX5	8.19e-09	283	51	8	30585729
Pubmed	The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation.	SMARCA4 DDX5 TBP	5.92e-08	6	51	3	17011493
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	WBP2 SYNRG KMT2C UBAP2 YLPM1 SMARCA4 RPRD2 PRKDC PRRC2A	9.62e-08	549	51	9	38280479
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	UBAP2 ZC3H4 YLPM1 SMARCA4 RPRD2 CHD7 DLX6 PRKDC TAF1L PRRC2A DDX5	1.09e-07	954	51	11	36373674
Pubmed	STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells.	CTAGE9 MIA2 CTAGE1 CTAGE8	2.33e-07	36	51	4	33230114
Pubmed	The phagosomal proteome in interferon-gamma-activated macrophages.	CTAGE9 MIA2 CTAGE1 CTAGE8	3.60e-07	40	51	4	19144319
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	WBP2 UBAP2 YLPM1 SMARCA4 RPRD2 PRRC2A	8.50e-07	220	51	6	24550385
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	SYNRG UBAP2 ZC3H4 YLPM1 SMARCA4 IST1 RPRD2 PRKDC PRRC2A DDX5	8.76e-07	934	51	10	33916271
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SYNRG ZC3H4 YLPM1 SMARCA4 CHD7 PRKDC ITPRID2 PRRC2A ALPI	1.69e-06	774	51	9	15302935
Pubmed	Brg1 regulates pro-lipogenic transcription by modulating SREBP activity in hepatocytes.	SREBF1 SMARCA4	2.11e-06	2	51	2	29857051
Pubmed	Serological detection of cutaneous T-cell lymphoma-associated antigens.	MIA2 CTAGE1 CTAGE4	2.39e-06	18	51	3	11149944
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	WBP2 CDIP1 UBAP2 MIA2 YLPM1 CHD7 ITPRID2	3.05e-06	430	51	7	35044719
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	WBP2 UBAP2 YLPM1 RPRD2 DDX5	3.18e-06	154	51	5	16055720
Pubmed	Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression.	GLI1 DLX6 MEIS2	5.15e-06	23	51	3	16672333
Pubmed	Human transcription factor protein interaction networks.	KMT2C UBAP2 YLPM1 SMARCA4 RPRD2 CHD7 DLX6 TAF1L PRRC2A SMAD5 TBP	5.68e-06	1429	51	11	35140242
Pubmed	Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes.	FAH PRKDC	6.32e-06	3	51	2	31915293
Pubmed	Reproductive and neurological Quaking(viable) phenotypes in a severe combined immune deficient mouse background.	PRKDC TBP	6.32e-06	3	51	2	15900494
Pubmed	Regulated expression of TAF1 in 1-cell mouse embryos.	TAF1L TBP	6.32e-06	3	51	2	16822332
Pubmed	Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis.	TAF1L TBP	6.32e-06	3	51	2	12217962
Pubmed	Lhx2 links the intrinsic and extrinsic factors that control optic cup formation.	DBX1 GLI1 SMAD5	1.06e-05	29	51	3	19906857
Pubmed	Inhibition of DNA-dependent protein kinase reduced palmitate and oleate-induced lipid accumulation in HepG2 cells.	SREBF1 PRKDC	1.26e-05	4	51	2	23184344
Pubmed	Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling.	CNTRL NSMAF	1.26e-05	4	51	2	10187805
Pubmed	Constitutive expression of the brg1 gene requires GC-boxes near to the transcriptional start site.	SMARCA4 TBP	1.26e-05	4	51	2	21149256
Pubmed	A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.	CTAGE9 MIA2 CTAGE1 CNTRL CTAGE8	1.28e-05	205	51	5	12040188
Pubmed	ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis.	GLI1 MEIS2 SMAD5	1.30e-05	31	51	3	36445780
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	KMT2C TENM4 ZC3H4 RPRD2 CHD7	2.00e-05	225	51	5	12168954
Pubmed	Gli1 marks a sentinel muscle stem cell population for muscle regeneration.	GLI1 PRKDC	2.10e-05	5	51	2	37914731
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	UBAP2 ZC3H4 YLPM1 RPRD2 PRRC2A MEIS2	2.56e-05	399	51	6	35987950
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	CACNA1A YLPM1 ITPRID2 NDUFB8	2.78e-05	118	51	4	21078624
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	YLPM1 SMARCA4 CHD7 PRKDC MEIS2 DDX5	3.02e-05	411	51	6	35182466
Pubmed	Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.	PRKDC TBP	3.15e-05	6	51	2	10601022
Pubmed	CAG repeats in Restless Legs syndrome.	CACNA1A TBP	3.15e-05	6	51	2	16389595
Pubmed	BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice.	GLI1 SMAD5	3.15e-05	6	51	2	28576771
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	MIA2 CTAGE1 CNTRL CTAGE8 YLPM1 CTAGE15 CTAGE6 PRKDC CTAGE4 DDX5	3.93e-05	1442	51	10	35575683
Pubmed	Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.	DBX1 GLI1 DLX6 MEIS2	4.06e-05	130	51	4	19386638
Pubmed	Genetic testing in spinocerebellar ataxia in Taiwan: expansions of trinucleotide repeats in SCA8 and SCA17 are associated with typical Parkinson's disease.	CACNA1A TBP	4.41e-05	7	51	2	14756671
Pubmed	Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression.	SREBF1 SMARCA4	4.41e-05	7	51	2	17074803
Pubmed	Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.	DBX1 GLI1 DLX6 MEIS2	4.57e-05	134	51	4	19030180
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	ZC3H4 YLPM1 SMARCA4 RPRD2 CHD7	4.60e-05	268	51	5	33640491
Pubmed	RNF12 catalyzes BRF1 ubiquitination and regulates RNA polymerase III-dependent transcription.	ITPRID2 ALPI TBP	5.55e-05	50	51	3	30413534
Pubmed	Generation of regionally specified neurons in expanded glial cultures derived from the mouse and human lateral ganglionic eminence.	DLX6 MEIS2	5.87e-05	8	51	2	11358480
Pubmed	CHD7 cooperates with PBAF to control multipotent neural crest formation.	SMARCA4 CHD7	5.87e-05	8	51	2	20130577
Pubmed	N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557 gametes and deletion mapping and complementation analysis of 31 mutations.	FAH TENM4	5.87e-05	8	51	2	10224267
Pubmed	Analysis of HIV-1 Gag protein interactions via biotin ligase tagging.	UBAP2 PRKDC PRRC2A	6.99e-05	54	51	3	25631074
Pubmed	The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation.	TAF1L TBP	7.54e-05	9	51	2	12665565
Pubmed	The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain.	SEMA3F DBX1	7.54e-05	9	51	2	26305926
Pubmed	Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice.	GLI1 SMAD5	7.54e-05	9	51	2	19934017
Pubmed	Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation.	SMARCA4 TBP	7.54e-05	9	51	2	21245044
Pubmed	Bone marrow endosteal stem cells dictate active osteogenesis and aggressive tumorigenesis.	GLI1 PRKDC	7.54e-05	9	51	2	37185464
Pubmed	The genetic aetiology of late-onset chronic progressive cerebellar ataxia. A population-based study.	CACNA1A TBP	9.42e-05	10	51	2	19259763
Pubmed	A role of DNA-PK for the metabolic gene regulation in response to insulin.	SREBF1 PRKDC	9.42e-05	10	51	2	19303849
Pubmed	Screening for premutation in the FMR1 gene in male patients suspected of spinocerebellar ataxia.	CACNA1A TBP	9.42e-05	10	51	2	19235102
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	KMT2C YLPM1 SREBF1 SMARCA4 RPRD2 CHD7 PRKDC TAF1L DDX5	9.88e-05	1294	51	9	30804502
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	KMT2C SMARCA4 PRKDC TBP	1.07e-04	167	51	4	20362541
Pubmed	DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis.	SREBF1 PRKDC DDX5	1.11e-04	63	51	3	37052853
Pubmed	Spatio-temporal dynamics of gene expression of the Edn1-Dlx5/6 pathway during development of the lower jaw.	DLX6 MEIS2	1.15e-04	11	51	2	20333701
Pubmed	Proteomics of herpes simplex virus replication compartments: association of cellular DNA replication, repair, recombination, and chromatin remodeling proteins with ICP8.	SMARCA4 PRKDC	1.38e-04	12	51	2	15140983
Pubmed	Gli3 Regulates Vomeronasal Neurogenesis, Olfactory Ensheathing Cell Formation, and GnRH-1 Neuronal Migration.	GLI1 MEIS2	1.38e-04	12	51	2	31767679
Pubmed	Developmental origin of the neuronal subtypes that comprise the amygdalar fear circuit in the mouse.	DBX1 MEIS2	1.38e-04	12	51	2	20484636
Pubmed	Mediator requirement for both recruitment and postrecruitment steps in transcription initiation.	SMARCA4 TBP	1.38e-04	12	51	2	15749018
Pubmed	Retinoids are produced by glia in the lateral ganglionic eminence and regulate striatal neuron differentiation.	DLX6 MEIS2	1.38e-04	12	51	2	10021349
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	YLPM1 RPRD2 DLX6 DDX5	1.43e-04	180	51	4	35198878
Pubmed	Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development.	TAF1L TBP	1.63e-04	13	51	2	11557891
Pubmed	Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy.	GLI1 SMAD5	1.63e-04	13	51	2	18434416
Pubmed	Noggin Overexpression Impairs the Development of Muscles, Tendons, and Aponeurosis in Soft Palates by Disrupting BMP-Smad and Shh-Gli1 Signaling.	GLI1 SMAD5	1.63e-04	13	51	2	34557486
Pubmed	Sox2-Evf2 lncRNA-mediated mechanisms of chromosome topological control in developing forebrain.	SMARCA4 DLX6	1.63e-04	13	51	2	33593819
Pubmed	Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development.	SMARCA4 CHD7	1.63e-04	13	51	2	23319608
Pubmed	The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.	GLI1 SMARCA4 TAF1L MEIS2	1.80e-04	191	51	4	24146773
Pubmed	A mouse model for Meckel syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signaling.	DBX1 GLI1	1.90e-04	14	51	2	19776033
Pubmed	Cytoneme signaling provides essential contributions to mammalian tissue patterning.	GLI1 SMAD5	1.90e-04	14	51	2	38171360
Pubmed	Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: a new mouse model of sirenomelia.	GLI1 SMAD5	1.90e-04	14	51	2	23028455
Pubmed	Lrp4 modulates extracellular integration of cell signaling pathways in development.	GLI1 SMAD5	1.90e-04	14	51	2	19116665
Pubmed	Development of the Proximal-Anterior Skeletal Elements in the Mouse Hindlimb Is Regulated by a Transcriptional and Signaling Network Controlled by Sall4.	GLI1 MEIS2	1.90e-04	14	51	2	32156750
Pubmed	Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome.	SMARCA4 TBP	1.90e-04	14	51	2	36289231
Pubmed	Roles of Bmp4 during tooth morphogenesis and sequential tooth formation.	DLX6 SMAD5	1.90e-04	14	51	2	23250216
Pubmed	Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function.	DBX1 GLI1	1.90e-04	14	51	2	21664576
Pubmed	AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication.	CACNA1A GLI1	1.90e-04	14	51	2	33305180
Pubmed	Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways.	SMARCA4 TBP	2.19e-04	15	51	2	23785148
Pubmed	Distinct temporal requirements for the homeobox gene Gsx2 in specifying striatal and olfactory bulb neuronal fates.	DBX1 MEIS2	2.19e-04	15	51	2	19709628
Pubmed	Arx Expression Suppresses Ventralization of the Developing Dorsal Forebrain.	DBX1 GLI1	2.19e-04	15	51	2	30659230
Pubmed	Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit.	SREBF1 SMARCA4	2.19e-04	15	51	2	14701856
Pubmed	A predictive model of bifunctional transcription factor signaling during embryonic tissue patterning.	DBX1 GLI1	2.19e-04	15	51	2	25458012
Pubmed	SMAD proteins control DROSHA-mediated microRNA maturation.	DDX5 SMAD5	2.19e-04	15	51	2	18548003
Pubmed	The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis.	TAF1L TBP	2.19e-04	15	51	2	14580349
Pubmed	Lrp4/Wise regulates palatal rugae development through Turing-type reaction-diffusion mechanisms.	GLI1 SMAD5	2.19e-04	15	51	2	30235284
Interaction	CTAGE1 interactions	MIA2 CTAGE1 CTAGE8 CTAGE15 CTAGE6 CTAGE4	3.56e-14	10	50	6	int:CTAGE1
Interaction	CTAGE4 interactions	MIA2 CTAGE1 CTAGE4	1.44e-08	3	50	3	int:CTAGE4
Interaction	CTAGE15 interactions	MIA2 CTAGE1 CTAGE15	1.43e-07	5	50	3	int:CTAGE15
Interaction	CTAGE6 interactions	MIA2 CTAGE1 CTAGE6	2.86e-07	6	50	3	int:CTAGE6
Interaction	CTAGE8 interactions	MIA2 CTAGE1 CTAGE8	2.86e-07	6	50	3	int:CTAGE8
Interaction	MIA2 interactions	MIA2 CTAGE1 CTAGE8 CTAGE15 CTAGE6 CTAGE4	3.53e-07	113	50	6	int:MIA2
Interaction	YAP1 interactions	WBP2 KMT2C CDIP1 UBAP2 GLI1 YLPM1 SMARCA4 RPRD2 PRKDC PRRC2A DDX5 SMAD5	1.11e-05	1095	50	12	int:YAP1
Interaction	MIA3 interactions	CACNA1A MIA2 CTAGE1 CTAGE8 CTAGE15 CTAGE6	2.22e-05	231	50	6	int:MIA3
Interaction	ZCCHC2 interactions	TXNIP ZCCHC2 PRRC2A	2.46e-05	23	50	3	int:ZCCHC2
Interaction	AR interactions	KMT2C ZC3H4 YLPM1 SREBF1 SMARCA4 RPRD2 CHD7 PRKDC ITPRID2 DDX5 TBP	2.48e-05	992	50	11	int:AR
Interaction	SMC5 interactions	UBAP2 ZC3H4 YLPM1 SMARCA4 RPRD2 CHD7 DLX6 PRKDC TAF1L PRRC2A DDX5	2.67e-05	1000	50	11	int:SMC5
Interaction	SOX7 interactions	KMT2C SMARCA4 CHD7 SMAD5	5.08e-05	82	50	4	int:SOX7
Interaction	CREM interactions	UBAP2 MIA2 PRKDC TBP	7.32e-05	90	50	4	int:CREM
Interaction	CTAGE7P interactions	MIA2 CTAGE6	8.99e-05	6	50	2	int:CTAGE7P
Interaction	SP7 interactions	KMT2C YLPM1 SMARCA4 RPRD2 CHD7 DLX6	1.02e-04	304	50	6	int:SP7
Interaction	NAA40 interactions	SYNRG UBAP2 ZC3H4 YLPM1 SMARCA4 IST1 RPRD2 PRKDC PRRC2A DDX5	1.21e-04	978	50	10	int:NAA40
Interaction	WWP2 interactions	TXNIP WBP2 UBAP2 YLPM1 SMARCA4 IST1 PRKDC PRRC2A DDX5	1.96e-04	840	50	9	int:WWP2
Interaction	ERG interactions	KMT2C SMARCA4 CHD7 PRKDC DDX5	2.24e-04	223	50	5	int:ERG
Interaction	SP1 interactions	SREBF1 SMARCA4 PRKDC MEIS2 DDX5 TBP	2.75e-04	365	50	6	int:SP1
Interaction	PAX6 interactions	KMT2C SMARCA4 CHD7 MEIS2 SMAD5 TBP	2.79e-04	366	50	6	int:PAX6
Interaction	UQCR11 interactions	ZC3H4 YLPM1 PRRC2A	3.08e-04	53	50	3	int:UQCR11
Interaction	SAA1 interactions	ZC3H4 YLPM1 PRRC2A	3.26e-04	54	50	3	int:SAA1
Interaction	POLR2A interactions	TXNIP ZC3H4 SREBF1 SMARCA4 RPRD2 DDX5 TBP	3.36e-04	536	50	7	int:POLR2A
Interaction	MAPKAPK2 interactions	ZC3H4 YLPM1 PRRC2A DDX5	3.40e-04	134	50	4	int:MAPKAPK2
Interaction	MTNR1B interactions	KMT2C SREBF1 RPRD2 PRKDC	3.49e-04	135	50	4	int:MTNR1B
Interaction	SMAD2 interactions	KMT2C GLI1 SMARCA4 PRKDC DDX5 SMAD5	3.65e-04	385	50	6	int:SMAD2
Cytoband	7q35	CTAGE8 CTAGE15 CTAGE6 CTAGE4 ASIC3	4.61e-09	55	51	5	7q35
Cytoband	Ensembl 112 genes in cytogenetic band chr7q35	CTAGE8 CTAGE15 CTAGE6 CTAGE4	9.25e-07	66	51	4	chr7q35
GeneFamily	CTAGE family	CTAGE9 MIA2 CTAGE1 CTAGE8 CTAGE15 CTAGE6 CTAGE4	1.71e-16	15	32	7	907
GeneFamily	WD repeat domain containing\|GRAM domain containing\|BEACH domain containing	WBP2 NSMAF	2.34e-04	13	32	2	1146
GeneFamily	NKL subclass homeoboxes and pseudogenes	DBX1 DLX6	6.25e-03	67	32	2	519
Coexpression	TERAO_AOX4_TARGETS_HG_UP	CTAGE9 MIA2 CTAGE1 CTAGE8	4.39e-07	32	51	4	MM922
Coexpression	BRACHAT_RESPONSE_TO_METHOTREXATE_DN	CTAGE9 MIA2 CTAGE1 CTAGE8	8.94e-07	38	51	4	MM1161
Coexpression	BRACHAT_RESPONSE_TO_CAMPTOTHECIN_DN	CTAGE9 MIA2 CTAGE1 CTAGE8	3.74e-06	54	51	4	MM1195
Coexpression	GSE10422_WT_VS_BAFF_TRANSGENIC_LN_BCELL_UP	DPP7 ZC3H4 IST1 RPRD2 SMAD5	2.63e-05	180	51	5	M357
Coexpression	PLASARI_TGFB1_TARGETS_1HR_DN	TXNIP MEIS2	3.70e-05	5	51	2	M2444
Coexpression	PLASARI_TGFB1_TARGETS_1HR_DN	TXNIP MEIS2	3.70e-05	5	51	2	MM943
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	KMT2C CHD7 ITPRID2 MEIS2 SMAD5	3.28e-06	200	51	5	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
Drug	Medrysone [2668-66-8]; Down 200; 11.6uM; PC3; HT_HG-U133A	TXNIP UBAP2 ZC3H4 YLPM1 MMP1 SMAD5	3.99e-06	197	49	6	4266_DN
Disease	liver cirrhosis (implicated_via_orthology)	FAH MMP1	1.76e-04	13	45	2	DOID:5082 (implicated_via_orthology)
Disease	Prostatic Neoplasms	KMT2C CDK2AP2 RPRD2 CHD7 PRKDC TAF1L	3.29e-04	616	45	6	C0033578
Disease	Malignant neoplasm of prostate	KMT2C CDK2AP2 RPRD2 CHD7 PRKDC TAF1L	3.29e-04	616	45	6	C0376358
Disease	stomach carcinoma (is_marker_for)	KMT2C MMP1	6.14e-04	24	45	2	DOID:5517 (is_marker_for)
Disease	Sezary Syndrome	KMT2C SMARCA4	7.79e-04	27	45	2	C0036920
Disease	age at first birth measurement	CACNA1A SEMA3F PRRC2A	8.22e-04	120	45	3	EFO_0009101
Disease	age at menopause	CHD7 PRKDC ZCCHC2 PRRC2A	1.15e-03	302	45	4	EFO_0004704

Protein segments in the cluster

Peptide	Gene	Start	Entry
EDGPKPMPPYSSMFI	CACNA1A	1211	O00555
FIPPHMSADGTYMPP	CDIP1	66	Q9H305
MSADGTYMPPGFYPP	CDIP1	71	Q9H305
PPGYMMYTVLPDGSP	CNTRL	1241	Q7Z7A1
DYRMMFPPPGQSYPD	CTAGE1	571	Q96RT6
RMMFPPPGQSYPDST	CTAGE4	606	Q8IX94
KMMFPPPGQSYPDSA	CTAGE6	606	Q86UF2
RMMFPPPGQSYPDST	CTAGE8	606	P0CG41
RMMFPPPGQSYPDST	CTAGE9	606	A4FU28
KMMFPPPGQSYPDSA	CTAGE15	606	A4D2H0
PQGTYASPPPMSPMK	CHD7	386	Q9P2D1
ASAKGVSMPPNSYMP	DLX6	141	P56179
PKPGPMAYADSMENF	NXPH2	66	O95156
PPSPMDPYAKMVGTP	KMT2C	1891	Q8NEZ4
GPMGMSMAQPSYTPP	MEIS2	396	O14770
SAPPMDGSPGKYMSH	ERN2	186	Q76MJ5
PATAAAPMIGYPMPT	DDX5	596	P17844
SSYMEMKGPPSGSPP	PEAR1	941	Q5VY43
MMFPGLLAPPAGYPS	DBX1	1	A6NMT0
AFMMAPKPGLDFSPF	NDNF	236	Q8TB73
MFNSMTPPPISSYGE	GLI1	1	P08151
PGFMPSPTFDMAQLY	ASIC3	136	Q9UHC3
HMTKDMFPGPYPRTP	NDUFB8	31	O95169
PMMRGPDPAAAPYST	ITPRID2	931	P28290
MFPMGTPDPEYPADA	ALPI	226	P09923
FGPPSMGYVQAMKPP	CDK2AP2	51	O75956
PSKPGFPDEPMREYM	C17orf67	41	Q0P5P2
PMPMPMPSANTPFSY	IST1	231	P53990
MPEPKFMYGSHYSSP	NSMAF	381	Q92636
PMGQMKPDDSKPPVY	FAH	176	P16930
FEYSGPPPSAMMNLE	RPRD2	836	Q5VT52
MMDYPYPTDFLGPLP	DPP7	271	Q9UHL4
RRMMFPPPGQSYPDS	MIA2	1211	Q96PC5
QWMPFSGKMPYPRPG	SEMA3F	396	Q13275
FLGMRPPGPQYTPDM	SYNRG	101	Q9UMZ2
SMDPGYPKMIAHDFP	MMP1	406	P03956
MTPGPYTSQPPDMYD	TAF1L	1656	Q8IZX4
PQFPPYRGMMPPFMY	PRRC2A	241	P48634
MGPPPSPMDQHSQGY	SMARCA4	106	P51532
DFGYVPNPKMPNTFM	SIAE	346	Q9HAT2
TPPPAYMPPDDQMGQ	SMAD5	221	Q99717
QPAPTPLKMYPSMPA	SREBF1	101	P36956
PLKMYPSMPAFSPGP	SREBF1	106	P36956
NPMPGPMYRVPSFFT	ZCCHC2	1036	Q9C0B9
MPSAFQYGPTMFVPP	UBAP2	921	Q5T6F2
MGSKSSPPSPYMGFS	USP43	961	Q70EL4
MTPGIPIFSPMMPYG	TBP	21	P20226
IPGYPKPDMDAMEPS	TENM4	2486	Q6N022
PVPPGSYMPPSQSYM	YLPM1	151	P49750
MGNMSMPPPFVPYSQ	YLPM1	511	P49750
HSGMMPPIPPAQNFY	ZC3H4	681	Q9UPT8
TSMSPDYPNPMFEHP	PRKDC	2566	P78527
SPIFMYAPEFKFMPP	TXNIP	361	Q9H3M7
PPEFYPGPPMMDGAM	WBP2	176	Q969T9