Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	1.70e-06	5	112	3	GO:0030156
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	NRIP1 PRAMEF33 PRAMEF10 NOC2L BCOR COMMD6 HDAC3 JUN GRHL1 TAF6 TAF1L DNMT3A	1.05e-04	582	112	12	GO:0140297
GeneOntologyCellularComponent	manchette	RIMBP3 RIMBP3C RIMBP3B DYNC1H1	1.45e-05	28	112	4	GO:0002177
GeneOntologyCellularComponent	Noc1p-Noc2p complex	NOC2L CASP8	2.85e-05	2	112	2	GO:0030690
GeneOntologyCellularComponent	RQC complex	NEMF LTN1	8.51e-05	3	112	2	GO:1990112
GeneOntologyCellularComponent	Noc complex	NOC2L CASP8	1.70e-04	4	112	2	GO:0030689
GeneOntologyCellularComponent	nuclear DNA-directed RNA polymerase complex	POLR3F CTR9 PRIM1 TAF6 TAF1L	3.58e-04	113	112	5	GO:0055029
GeneOntologyCellularComponent	DNA-directed RNA polymerase complex	POLR3F CTR9 PRIM1 TAF6 TAF1L	4.04e-04	116	112	5	GO:0000428
GeneOntologyCellularComponent	RNA polymerase complex	POLR3F CTR9 PRIM1 TAF6 TAF1L	4.54e-04	119	112	5	GO:0030880
GeneOntologyCellularComponent	chromatin	FOXN1 NRIP1 PRAMEF33 PRAMEF10 NOC2L FAM47C HDAC3 TARDBP JUN GRHL1 BRDT CTR9 ELF1 ZFHX3 ELK4 TAF6 TAF1L DNMT3A	8.66e-04	1480	112	18	GO:0000785
GeneOntologyCellularComponent	rod photoreceptor outer segment	RHO CNGB1	9.99e-04	9	112	2	GO:0120200
GeneOntologyCellularComponent	nuclear protein-containing complex	NRIP1 IPO7 NOC2L RPP40 INTS1 CASP8 MSH3 BCOR PRPF8 POLR3F RANBP17 HDAC3 JUN CTR9 PRIM1 TAF6 TAF1L	1.04e-03	1377	112	17	GO:0140513
Domain	SH3_2	ITSN1 STAC RIMBP3 RIMBP3C RIMBP3B	1.61e-04	86	111	5	PF07653
Domain	SH3_2	ITSN1 STAC RIMBP3 RIMBP3C RIMBP3B	1.61e-04	86	111	5	IPR011511
Domain	ROC_dom	MFHAS1 LRRK1	2.08e-04	4	111	2	IPR020859
Domain	ROC	MFHAS1 LRRK1	2.08e-04	4	111	2	PS51424
Domain	Bromodomain_CS	BRDT TAF1L PHIP	4.81e-04	26	111	3	IPR018359
Domain	P-loop_NTPase	MYO1A MYO1D MFHAS1 AK9 MSH3 LRRK1 SLFN14 RHOBTB1 CHST15 GAL3ST3 TOR3A DNAH8 YME1L1 DYNC1H1	4.99e-04	848	111	14	IPR027417
Domain	ETS_DOMAIN_1	ETV3L ELF1 ELK4	6.01e-04	28	111	3	PS00345
Domain	ETS_DOMAIN_2	ETV3L ELF1 ELK4	6.01e-04	28	111	3	PS00346
Domain	Ets	ETV3L ELF1 ELK4	6.01e-04	28	111	3	PF00178
Domain	ETS	ETV3L ELF1 ELK4	6.01e-04	28	111	3	SM00413
Domain	Ets_dom	ETV3L ELF1 ELK4	6.01e-04	28	111	3	IPR000418
Domain	ETS_DOMAIN_3	ETV3L ELF1 ELK4	6.01e-04	28	111	3	PS50061
Domain	Myosin_TH1	MYO1A MYO1D	7.21e-04	7	111	2	PF06017
Domain	Myosin_TH1	MYO1A MYO1D	7.21e-04	7	111	2	IPR010926
Domain	TH1	MYO1A MYO1D	7.21e-04	7	111	2	PS51757
Domain	DHC_N1	DNAH8 DYNC1H1	9.57e-04	8	111	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH8 DYNC1H1	9.57e-04	8	111	2	IPR013594
Domain	SH3_9	ITSN1 RIMBP3 RIMBP3C RIMBP3B	1.20e-03	78	111	4	PF14604
Domain	BROMODOMAIN_1	BRDT TAF1L PHIP	1.37e-03	37	111	3	PS00633
Domain	Bromodomain	BRDT TAF1L PHIP	1.48e-03	38	111	3	PF00439
Domain	-	MFHAS1 AK9 MSH3 LRRK1 SLFN14 RHOBTB1 CHST15 GAL3ST3 TOR3A DNAH8 YME1L1 DYNC1H1	1.60e-03	746	111	12	3.40.50.300
Domain	BROMODOMAIN_2	BRDT TAF1L PHIP	1.85e-03	41	111	3	PS50014
Domain	Bromodomain	BRDT TAF1L PHIP	1.98e-03	42	111	3	IPR001487
Domain	BROMO	BRDT TAF1L PHIP	1.98e-03	42	111	3	SM00297
Domain	-	BRDT TAF1L PHIP	1.98e-03	42	111	3	1.20.920.10
Domain	MIRO-like	MFHAS1 LRRK1	2.62e-03	13	111	2	IPR013684
Domain	Roc	MFHAS1 LRRK1	2.62e-03	13	111	2	PF08477
Domain	Dynein_heavy_chain_D4_dom	DNAH8 DYNC1H1	3.04e-03	14	111	2	IPR024317
Domain	Dynein_HC_stalk	DNAH8 DYNC1H1	3.04e-03	14	111	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH8 DYNC1H1	3.04e-03	14	111	2	IPR013602
Domain	DHC_N2	DNAH8 DYNC1H1	3.04e-03	14	111	2	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH8 DYNC1H1	3.04e-03	14	111	2	IPR011704
Domain	MT	DNAH8 DYNC1H1	3.04e-03	14	111	2	PF12777
Domain	AAA_8	DNAH8 DYNC1H1	3.04e-03	14	111	2	PF12780
Domain	AAA_5	DNAH8 DYNC1H1	3.04e-03	14	111	2	PF07728
Domain	DHC_fam	DNAH8 DYNC1H1	3.49e-03	15	111	2	IPR026983
Domain	Dynein_heavy	DNAH8 DYNC1H1	3.49e-03	15	111	2	PF03028
Domain	IBN_N	IPO7 RANBP17	3.49e-03	15	111	2	PF03810
Domain	Dynein_heavy_dom	DNAH8 DYNC1H1	3.49e-03	15	111	2	IPR004273
Domain	IBN_N	IPO7 RANBP17	3.98e-03	16	111	2	SM00913
Domain	Importin-beta_N	IPO7 RANBP17	4.49e-03	17	111	2	IPR001494
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	1.33e-07	4	113	3	19091768
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	3.32e-07	5	113	3	17855024
Pubmed	Histone recognition and large-scale structural analysis of the human bromodomain family.	BRDT TAF1L PHIP	1.16e-06	7	113	3	22464331
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	IPO7 IMPDH2 VEZT NOC2L SCAMP1 ITSN1 PIK3R3 OAT PRPF8 PIGU VANGL2 RAB3GAP1 CTR9 DNAJC24 YME1L1 PCDH7 VPS13B PUS7	1.46e-06	1487	113	18	33957083
Pubmed	Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice.	BCOR DNMT3A	1.05e-05	2	113	2	33159179
Pubmed	Structure and assembly pathway of the ribosome quality control complex.	NEMF LTN1	1.05e-05	2	113	2	25578875
Pubmed	Expression Analysis of the Stem Cell Marker Pw1/Peg3 Reveals a CD34 Negative Progenitor Population in the Hair Follicle.	FOXN1 PEG3	1.05e-05	2	113	2	27862634
Pubmed	Stable expression of a c-JUN deletion mutant in two malignant mouse epidermal cell lines blocks tumor formation in nude mice.	FOXN1 JUN	1.05e-05	2	113	2	8123597
Pubmed	The T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini.	FGD2 DNAH8	1.05e-05	2	113	2	12297094
Pubmed	JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun.	HDAC3 JUN	1.05e-05	2	113	2	12853483
Pubmed	Receptor-interacting protein 140 binds c-Jun and inhibits estradiol-induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect.	NRIP1 JUN	1.05e-05	2	113	2	12554755
Pubmed	c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis.	HDAC3 JUN	1.05e-05	2	113	2	17244530
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	1.18e-05	14	113	3	17662146
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	EPM2A IPO7 OAT NEDD1 PRPF8 VANGL2 USP5 ERLIN2 CTR9 SEC11A LTN1 YME1L1 PUS7	1.75e-05	974	113	13	28675297
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	IPO7 MSH3 BCOR POLR3F TARDBP USP5 CTR9 DYNC1H1	2.29e-05	357	113	8	37059091
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	IPO7 IMPDH2 INTS1 MSH3 PRPF8 POLR3F HDAC3 TARDBP USP5 CTR9 PRIM1 TAF6 PUS7	2.65e-05	1014	113	13	32416067
Pubmed	Green tea polyphenol epigallocatechin 3-gallate, contributes to the degradation of DNMT3A and HDAC3 in HCT 116 human colon cancer cells.	HDAC3 DNMT3A	3.13e-05	3	113	2	24324066
Pubmed	Peripherin-2 couples rhodopsin to the CNG channel in outer segments of rod photoreceptors.	RHO CNGB1	3.13e-05	3	113	2	24963162
Pubmed	Grating acuity at different luminances in wild-type mice and in mice lacking rod or cone function.	RHO CNGB1	3.13e-05	3	113	2	15623801
Pubmed	Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing.	NRIP1 HDAC3	3.13e-05	3	113	2	11006275
Pubmed	GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3.	HDAC3 GRHL1	3.13e-05	3	113	2	24419085
Pubmed	Pattern of segmental recombination in the distal inversion of mouse t haplotypes.	FGD2 DNAH8	3.13e-05	3	113	2	12226709
Pubmed	Epigenetic modifiers DNMT3A and BCOR are recurrently mutated in CYLD cutaneous syndrome.	BCOR DNMT3A	3.13e-05	3	113	2	31624251
Pubmed	Role of RDS and Rhodopsin in Cngb1-Related Retinal Degeneration.	RHO CNGB1	3.13e-05	3	113	2	26934134
Pubmed	Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport.	TARDBP DNMT3A	3.13e-05	3	113	2	25743254
Pubmed	A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.	NRIP1 FAT4 VANGL2 JUN	3.91e-05	58	113	4	19734545
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	NRIP1 FAT4 IPO7 MYO1D BCOR PIGU HORMAD1 RAB3GAP1 SEC11A YME1L1	4.59e-05	638	113	10	31182584
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	IPO7 IMPDH2 MYO1A MYO1D ITGA2 SORCS1 TARDBP LTN1 YME1L1 DYNC1H1	5.16e-05	647	113	10	26618866
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	IPO7 IMPDH2 MYO1D NOC2L INTS1 OAT PRPF8 USP5 PHIP DYNC1H1	5.57e-05	653	113	10	22586326
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	IPO7 IMPDH2 VEZT NOC2L USP5 RAB3GAP1 ERLIN2 SEC11A UGT8 SLC47A1 YME1L1 DYNC1H1	5.86e-05	942	113	12	31073040
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	IPO7 IMPDH2 MYO1D NOC2L OAT MSH3 PRPF8 TARDBP ERLIN2 CTR9 PRIM1 SEC11A NEMF PHIP DYNC1H1	5.98e-05	1425	113	15	30948266
Pubmed	Down-regulation of PROS1 gene expression by 17beta-estradiol via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complex.	NRIP1 HDAC3	6.25e-05	4	113	2	20200160
Pubmed	Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration.	RHO CNGB1	6.25e-05	4	113	2	23178122
Pubmed	Differential localization and dynamics of class I myosins in the enterocyte microvillus.	MYO1A MYO1D	6.25e-05	4	113	2	20089841
Pubmed	AP-1-controlled hepatocyte growth factor activation promotes keratinocyte migration via CEACAM1 and urokinase plasminogen activator/urokinase plasminogen receptor.	JUN PLAU	6.25e-05	4	113	2	19020551
Pubmed	Deficient ghrelin receptor-mediated signaling compromises thymic stromal cell microenvironment by accelerating thymic adiposity.	FOXN1 GHSR	6.25e-05	4	113	2	19054770
Pubmed	Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity.	MFHAS1 LRRC2	6.25e-05	4	113	2	20616063
Pubmed	Binding of microtubule-associated protein 1B to LIS1 affects the interaction between dynein and LIS1.	DNAH8 DYNC1H1	6.25e-05	4	113	2	15762842
Pubmed	Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.	IMPDH2 PRPF8 MYOF ERLIN2 CTR9 SEC11A YME1L1 DYNC1H1	7.42e-05	422	113	8	27342126
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	IPO7 IMPDH2 OAT NEDD1 PRPF8 EDEM3 TARDBP MYOF ERLIN2 SEC11A NEMF HACL1 TOR3A DYNC1H1	8.24e-05	1297	113	14	33545068
Pubmed	Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.	FOXN1 OAT LRRK1 VANGL2	9.17e-05	72	113	4	25917818
Pubmed	The testis-specific double bromodomain-containing protein BRDT forms a complex with multiple spliceosome components and is required for mRNA splicing and 3'-UTR truncation in round spermatids.	TARDBP BRDT	1.04e-04	5	113	2	22570411
Pubmed	RIP140 in thyroid hormone-repression and chromatin remodeling of Crabp1 gene during adipocyte differentiation.	NRIP1 HDAC3	1.04e-04	5	113	2	19778926
Pubmed	c-Jun controls histone modifications, NF-kappaB recruitment, and RNA polymerase II function to activate the ccl2 gene.	HDAC3 JUN	1.04e-04	5	113	2	18443042
Pubmed	Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase.	JUN ELK4	1.04e-04	5	113	2	9020136
Pubmed	Gene repressive activity of RIP140 through direct interaction with CDK8.	NRIP1 HDAC3	1.04e-04	5	113	2	21868449
Pubmed	Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates.	RHO VANGL2	1.04e-04	5	113	2	16170314
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	ITSN1 PRPF8 TARDBP JUN MYOF TOR3A DYNC1H1	1.10e-04	332	113	7	37433992
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	IPO7 VEZT SCAMP1 ITSN1 VANGL2 USP5 RAB3GAP1 ERLIN2	1.14e-04	449	113	8	31732153
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	IPO7 IMPDH2 NOC2L CASP8 MSH3 PRPF8 TARDBP USP5 RAB3GAP1 CTR9 LTN1 YME1L1 PHIP DYNC1H1	1.28e-04	1353	113	14	29467282
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	IPO7 IMPDH2 PRPF8 JUN MYOF USP5 DYNC1H1	1.37e-04	344	113	7	30333137
Pubmed	Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.	ITSN1 TAF1L PUS7	1.40e-04	31	113	3	25838543
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	FAT4 ANPEP ITGA2 PIGU EDEM3 MYOF USP5 ERLIN2 SEC11A LTN1 UGT8 TOR3A PCDH7	1.46e-04	1201	113	13	35696571
Pubmed	Specific protein kinase C isoforms are required for rod photoreceptor differentiation.	PIK3R3 RHO	1.56e-04	6	113	2	22171059
Pubmed	SCAMP1 function in endocytosis.	SCAMP1 ITSN1	1.56e-04	6	113	2	10777571
Pubmed	Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during development.	FOXN1 CAPN6	1.56e-04	6	113	2	10559499
Pubmed	KR-POK interacts with p53 and represses its ability to activate transcription of p21WAF1/CDKN1A.	BCOR HDAC3	1.56e-04	6	113	2	22253232
Pubmed	RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes.	NRIP1 DNMT3A	1.56e-04	6	113	2	17972916
Pubmed	The ribosome quality control pathway can access nascent polypeptides stalled at the Sec61 translocon.	NEMF LTN1	1.56e-04	6	113	2	25877867
Pubmed	Suppression of receptor interacting protein 140 repressive activity by protein arginine methylation.	NRIP1 HDAC3	1.56e-04	6	113	2	17053781
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	IPO7 MYO1D VEZT SCAMP1 PIK3R3 BCOR TARDBP CTR9 PRIM1 LTN1 YME1L1 PCDH7	1.61e-04	1049	113	12	27880917
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	EPHB3 VEZT SCAMP1 INTS1 OAT NEDD1 PIGU MYOF HARS2 NEMF LTN1 PLAU	1.79e-04	1061	113	12	33845483
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	IPO7 IMPDH2 OAT PRPF8 EDEM3 TARDBP ERLIN2 SEC11A UGT8	1.82e-04	613	113	9	22268729
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	IPO7 IMPDH2 MYO1D NOC2L OAT PRPF8 SEC11A DYNC1H1	1.90e-04	484	113	8	31995728
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	PRAMEF33 PRAMEF10 C3orf20 DENND4C POLR3F HDAC3 USP5 ERLIN2 BRDT CTR9 HACL1 ELK4 DNMT3A	2.03e-04	1242	113	13	30973865
Pubmed	De novo DNA methylation independent establishment of maternal imprint on X chromosome in mouse oocytes.	PEG3 DNMT3A	2.17e-04	7	113	2	18932249
Pubmed	Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity.	FAT4 VANGL2	2.17e-04	7	113	2	22510986
Pubmed	Mapping HSA10 homologous loci in cattle.	OAT PLAU	2.17e-04	7	113	2	1655359
Pubmed	Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration.	RHO CNGB1	2.17e-04	7	113	2	25392995
Pubmed	Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth.	HDAC3 JUN	2.17e-04	7	113	2	17182846
Pubmed	Similarities and Differences in the Way Transmembrane-Type Ligands Interact with the Elk Subclass of Eph Receptors.	EPHB3 ELF1	2.17e-04	7	113	2	8954633
Pubmed	A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis.	FOXN1 JUN	2.17e-04	7	113	2	23948297
Pubmed	Myosins: a diverse superfamily.	MYO1A MYO1D	2.17e-04	7	113	2	10722873
Pubmed	Localization of extracellular matrix receptors in ICGN mice, a strain of mice with hereditary nephrotic syndrome.	ITGA2 RHO	2.17e-04	7	113	2	11767049
Pubmed	Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.	HDAC3 JUN	2.17e-04	7	113	2	22679019
Pubmed	Human transcription factor protein interaction networks.	IMPDH2 MYO1D BCOR HDAC3 TARDBP JUN ERLIN2 ELF1 ZFHX3 ELK4 TAF6 TAF1L PCDH7 DYNC1H1	2.26e-04	1429	113	14	35140242
Pubmed	HDAC3 Is a Master Regulator of mTEC Development.	FOXN1 HDAC3	2.89e-04	8	113	2	27068467
Pubmed	Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting.	PEG3 DNMT3A	2.89e-04	8	113	2	15215868
Pubmed	Oxidative stress-induced JNK1/2 activation triggers proapoptotic signaling and apoptosis that leads to diabetic embryopathy.	CASP8 JUN	2.89e-04	8	113	2	22688338
Pubmed	A novel POK family transcription factor, ZBTB5, represses transcription of p21CIP1 gene.	BCOR HDAC3	2.89e-04	8	113	2	19491398
Pubmed	JNK regulates autocrine expression of TGF-beta1.	HDAC3 JUN	2.89e-04	8	113	2	15260977
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	IPO7 IMPDH2 PRPF8 PIGU TARDBP ERLIN2 SEC11A LTN1 TOR3A	3.03e-04	657	113	9	36180527
Pubmed	Implications of Nef: host cell interactions in viral persistence and progression to AIDS.	CASP8 JUN CD3G	3.25e-04	41	113	3	20012528
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	IMPDH2 NOC2L RPP40 INTS1 BCOR HDAC3 MYOF HARS2 CTR9 LTN1 ZFHX3 TAF6 TAF1L YME1L1	3.61e-04	1497	113	14	31527615
Pubmed	CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.	IPO7 IMPDH2 MYO1A MYO1D OAT DYNC1H1	3.69e-04	288	113	6	31501420
Pubmed	The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation.	TAF6 TAF1L	3.71e-04	9	113	2	12665565
Pubmed	p38-2, a novel mitogen-activated protein kinase with distinct properties.	JUN ELK4	3.71e-04	9	113	2	9235954
Pubmed	The effects of trichostatin A on mRNA expression of chromatin structure-, DNA methylation-, and development-related genes in cloned mouse blastocysts.	HDAC3 DNMT3A	3.71e-04	9	113	2	18241125
Pubmed	Typing recombinant inbred mouse strains for microsatellite markers.	ANPEP PLAU	3.71e-04	9	113	2	8507976
Pubmed	Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily.	IPO7 RANBP17	3.71e-04	9	113	2	11024021
Pubmed	The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety.	BCOR PRPF8 HDAC3	3.75e-04	43	113	3	26487511
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	INTS1 MSH3 LTN1 YME1L1	3.78e-04	104	113	4	31240132
Pubmed	TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.	JUN TAF6 TAF1L	4.58e-04	46	113	3	25209997
Pubmed	BCoR, a novel corepressor involved in BCL-6 repression.	BCOR HDAC3	4.63e-04	10	113	2	10898795
Pubmed	Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice.	JUN PLAU	4.63e-04	10	113	2	21403399
Pubmed	A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.	NRIP1 HDAC3	4.63e-04	10	113	2	14980219
Pubmed	Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease.	FAT4 VANGL2	4.63e-04	10	113	2	18604206
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	MYO1D NOC2L SCAMP1 ITSN1 CASP8 NEDD1 RIMBP3 HDAC3 PRIM1 DYNC1H1	4.78e-04	853	113	10	28718761
Pubmed	Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.	IPO7 IMPDH2 PRPF8 LTN1	4.84e-04	111	113	4	32683582
Pubmed	Multiple mouse chromosomal loci for dynein-based motility.	PLAU DNAH8 DYNC1H1	4.88e-04	47	113	3	8812413
Cytoband	17q11-q12	FOXN1 MYO1D	8.95e-05	6	113	2	17q11-q12
GeneFamily	ETS transcription factor family	ETV3L ELF1 ELK4	1.92e-04	28	73	3	534
GeneFamily	Myosins, class I	MYO1A MYO1D	4.43e-04	8	73	2	1097
ToppCell	(08)_Brush+PNEC-(2)_GFP_FOXI1\|(08)_Brush+PNEC / shred by cell type by condition	NRIP1 ITSN1 JUN CHST15 NEMF PCDH7	1.44e-06	138	113	6	817e3f639604ea95adae01e8685ffaa2e0aff7a8
Disease	retinitis pigmentosa (implicated_via_orthology)	PRPF8 RHO EPG5 CNGB1	2.69e-06	27	107	4	DOID:10584 (implicated_via_orthology)
Disease	3-amino-2-piperidone measurement	OAT CHST15	3.90e-05	3	107	2	EFO_0800097
Disease	carbohydrate sulfotransferase 15 measurement	OAT CHST15	1.29e-04	5	107	2	EFO_0008066
Disease	retinitis pigmentosa (is_implicated_in)	PRPF8 RHO CNGB1	4.47e-04	41	107	3	DOID:10584 (is_implicated_in)
Disease	high grade glioma (is_marker_for)	PIK3R3 HDAC3 PLAU	4.80e-04	42	107	3	DOID:3070 (is_marker_for)
Disease	primary immunodeficiency disease (is_implicated_in)	FOXN1 CASP8 POLR3F	4.80e-04	42	107	3	DOID:612 (is_implicated_in)
Disease	Acute Cerebrovascular Accidents	PRPF8 ZFHX3 PLAU	1.01e-03	54	107	3	C0751956
Disease	Disorder of eye	OAT BCOR PRPF8 RHO CNGB1	1.07e-03	212	107	5	C0015397
Disease	Intellectual Disability	PIGU ERLIN2 TAF6 PHIP DYNC1H1 PUS7 DNMT3A	1.24e-03	447	107	7	C3714756
Disease	Cerebrovascular accident	PRPF8 ZFHX3 PLAU	1.50e-03	62	107	3	C0038454
Disease	Mental Retardation, Psychosocial	ERLIN2 PHIP DYNC1H1 DNMT3A	1.67e-03	139	107	4	C0025363
Disease	Profound Mental Retardation	ERLIN2 PHIP DYNC1H1 DNMT3A	1.67e-03	139	107	4	C0020796
Disease	Mental deficiency	ERLIN2 PHIP DYNC1H1 DNMT3A	1.67e-03	139	107	4	C0917816
Disease	lung non-small cell carcinoma (is_implicated_in)	MSH3 HDAC3 ZFHX3 PLAU	1.67e-03	139	107	4	DOID:3908 (is_implicated_in)
Disease	Microcephaly	DYNC1H1 PUS7 DNMT3A	1.88e-03	67	107	3	C0025958
Disease	aggressive behaviour measurement, ADHD symptom measurement	MFHAS1 PLAU PCDH7	1.96e-03	68	107	3	EFO_0007826, EFO_0007860
Disease	susceptibility to mononucleosis measurement	FAT4 DNAH8 PCDH7	2.04e-03	69	107	3	EFO_0008403
Disease	emphysema pattern measurement	MYO1D HYKK	2.14e-03	19	107	2	EFO_0005850
Disease	heart failure, diabetes mellitus, stroke, atrial fibrillation, mortality, coronary artery disease, cancer	GRHL1 ZFHX3	2.37e-03	20	107	2	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004352, MONDO_0004992
Disease	Retinitis pigmentosa	PRPF8 RHO CNGB1	2.49e-03	74	107	3	cv:C0035334
Disease	prostate carcinoma (is_marker_for)	HDAC3 JUN	3.14e-03	23	107	2	DOID:10286 (is_marker_for)
Disease	exploratory eye movement measurement	EPM2A MBOAT1 UGT8	3.22e-03	81	107	3	EFO_0007700
Disease	obsolete_red blood cell distribution width	NRIP1 MYO1A MYO1D ITSN1 AK9 SLFN14 DENND4C EPG5 PRIM1 GAL3ST3 SLC47A1 OR6Y1	3.55e-03	1347	107	12	EFO_0005192
Disease	carotid plaque build	EPG5 GHSR BRDT	3.57e-03	84	107	3	EFO_0006501

Protein segments in the cluster

Peptide	Gene	Start	Entry
LYYPQMLYIKKISNI	PRAMEF33	266	A0A0G2JMD5
AMQKYLRTTKQQPYH	VANGL2	401	Q9ULK5
IIQYRLPMKKNNNLY	ACSBG2	181	Q5FVE4
LMVLEAYQKYLAQKP	EPG5	921	Q9HCE0
QNKSKPLQVYYRMCQ	CD3G	91	P09693
VYQFKEMPKDLIYIN	ELF1	286	P32519
KQPMYRKAIYEVLQV	DNMT3A	361	Q9Y6K1
YYTIIKNPMDLNTIK	BRDT	66	Q58F21
LKRGYSYQIKMCPQN	ADGRF1	441	Q5T601
GAMVNYIKKTYPLTQ	ABHD2	186	P08910
SADRYMAIVQPKYAK	GPR18	116	Q14330
GMVLYSLKQNPKNLF	FAT4	926	Q6V0I7
RSEVYGPMKNYLKKQ	ANPEP	711	P15144
LTGYNDYIKMSINPK	CTBS	231	Q01459
NKYSLNMYKALLPQQ	BCOR	211	Q6W2J9
QIYPMKLKGISICYS	RANBP17	821	Q9H2T7
YSKALPQRMYSVLTK	RAB3GAP1	951	Q15042
APKLKIFMAQYNYNP	RIMBP3B	831	A6NNM3
APKLKIFMAQYNYNP	RIMBP3C	831	A6NJZ7
KSAAIYNPVIYIMMN	RHO	296	P08100
ELASKKSLPMNYYTV	HACL1	366	Q9UJ83
VKKQLAPYLKSLMGY	LTN1	136	O94822
YQKLILMYHPDKQST	DNAJC24	31	Q6P3W2
VKTPIQRAMQVYKYK	FAM47C	1011	Q5HY64
KSIYTPLELQYIEMK	MSH3	226	P20585
KVQYFLMAKRPAVYI	EPM2A	291	O95278
IIKIELSYNKIMYFP	LRRD1	466	A4D1F6
KIYQYDLRMLKSPVK	NEDD1	271	Q8NHV4
MTNYKYKVKLTPGVQ	NEMF	1006	O60524
MKGIPYIAAYQKELA	MFHAS1	386	Q9Y4C4
YLSLMYLAKIKPNIF	INTS1	161	Q8N201
QKIYIYTLKGMCPLN	LRRK1	1601	Q38SD2
VAILMKNLYSKSPNY	MYO1A	571	Q9UBC5
YGYSNPKILKQSMTL	JUN	26	P05412
MIKYIKDKYPNLQVI	IMPDH2	286	P12268
QMAKQLGYKLLPAFN	EDEM3	181	Q9BZQ6
YLKGPSQRLIKYQML	MCF2L2	751	Q86YR7
YKEKQYMAPRVLQQT	IPO7	311	O95373
TNNKYSKQMRLHPYI	PCDH7	1051	O60245
TYTYMKLNLNPKMQL	DNAH8	2301	Q96JB1
LLYKNKLTYLPYSML	LRRC2	266	Q9BYS8
LTKTNPILYYMLQKG	NRIP1	1061	P48552
KLQQYIAPGMKVYID	EPHB3	596	P54753
YTKEKNPLMYLTGVQ	ITGA2	996	P17301
PVLKQMYITYVRNCK	NOC2L	331	Q9Y3T9
YLLQRQYIPVKMKSK	PIGU	206	Q9H490
RSLKYPYVAVMLKVA	COMMD6	36	Q7Z4G1
LYKKMIVFKPYQASQ	HDAC3	41	O15379
KLVTLLENYKEMYQP	PEG3	116	Q9GZU2
LTPEYLQLMKYKAIA	ERLIN2	276	O94905
QKMNPYKIDIGAVYS	PRIM1	71	P49642
KLDVKLMYPVSRYQQ	PIK3R3	151	Q92569
MPEVQYSNYLLRKQK	GAL3ST3	386	Q96A11
LYPENKDYLMVTAKT	HYKK	326	A2RU49
MTYLNKGQFYPITLK	GRHL1	271	Q9NZI5
KPNMNYDKLSRALRY	ELK4	51	P28324
AAINPILYNIMSKKY	GHSR	316	Q92847
YQQYTAMAPKLLARI	C3orf20	11	Q8ND61
LQYKMYKTPIFLNEV	ITSN1	1511	Q15811
GTQVEKYKKNYLPMQ	CENPJ	1086	Q9HC77
VLPKYERIMQKYNLL	UGT8	211	Q16880
KVLKAYPNNYETMKI	CTR9	366	Q6PD62
MKTARIKPNAITYGY	DENND4C	846	Q5VZ89
YQMKSKPRGYCLIIN	CASP8	226	Q14790
RLCYLYVVMQASKPK	MBOAT1	281	Q6ZNC8
IQKLAPFLKMYSEYV	FGD2	186	Q7Z6J4
INSVSAMKLSPYYKV	DYNC1H1	1501	Q14204
KKYLRMVVLAVYTNP	HORMAD1	91	Q86X24
KPQMNYDKLSRALRY	ETV3L	86	Q6ZN32
YLKKGNYVLVPTMFQ	CAPN6	461	Q9Y6Q1
NPLIYSLRNKDMKYA	OR11H7	286	Q8NGC8
LKNLVMNTGPYYFVK	RPP40	56	O75818
VKALMDNPTLYLEKY	TAF6	286	P49848
APLAQKMLTFTYKYI	AK9	1331	Q5TCS8
QMEKSQALYIPKDAY	SPHKAP	331	Q2M3C7
YLYPEQLKMTVVKLI	PLAU	326	P00749
KLLPSGSQKYLDYMQ	SLFN14	86	P0C7P3
MLYKNNPKLLTQLHY	HARS2	441	P49590
LVYVVNYPKDNKRKM	TARDBP	71	Q13148
APKLKIFMAQYNYNP	RIMBP3	831	Q9UFD9
VNKKFVPDYYKMIVN	TAF1L	1551	Q8IZX4
KPIYSYSILIFMALK	FOXN1	271	O15353
LSKYLRVKPNIFSYM	PUS7	276	Q96PZ0
IPVEFQKTVKLMYYL	SCAMP1	141	O15126
KKKVYMLYNLQPDRS	POLR3F	146	Q9H1D9
MQAVLDYLYTKQLSP	RHOBTB1	536	O94844
RPKLMYAYNSNKVVS	OR6Y1	266	Q8NGX8
YITKLFNYHKVLPMN	OAT	126	P04181
PATFLYMLQVKYLLN	SLC47A1	166	Q96FL8
LLAVFKNKNLQAPMY	MC2R	46	Q01718
NNISYMKDYPSIKLI	CHST15	141	Q7LFX5
VKYMNFYKIPKSVQN	CNGB1	901	Q14028
NMKYELQLANPKEFY	PRPF8	2291	Q6P2Q9
MYLAQNYDIPNLAKK	STMP1	16	E0CX11
KLNLGQYKGPIQYMV	TRIM69	296	Q86WT6
SKVYALRTQKKMYPQ	TSGA13	191	Q96PP4
PVQKALYKDVMLENY	ZNF616	26	Q08AN1
ILSEDYNKMTPVKNY	WDFY2	96	Q96P53
YNIIPLYNSMKKKVL	PHIP	1266	Q8WWQ0
SKDPLQMNTYVALYK	STAC	281	Q99469
LYYPQMLYIKKISNI	PRAMEF10	266	O60809
MYIVQKYISNPLLIG	TTLL2	236	Q9BWV7
IVTILMNDYPKFKYA	SEC11A	151	P67812
IAYYTKDAMPINKAT	YME1L1	606	Q96TA2
MKFTYLIPQNKYIQL	TMEM225	86	Q6GV28
MSYVNRYIKNLKPSD	VPS13B	11	Q7Z7G8
QAARLATLYMLKNYP	VEZT	271	Q9HBM0
PKYVDLYKEQLMSQI	TOR3A	206	Q9H497
SYLYVCPTNKRKIML	SORCS1	231	Q8WY21
KVKYTQRVDYIMQLP	USP5	476	P45974
YLKDPAAYPKIQMLA	TM6SF1	256	Q9BZW5
LYQKYLLDSNPTRKM	ZFHX3	2656	Q15911
KQYKVMKTIPLYNLT	MYO1D	891	O94832
VAVLLYSLPNYLSMK	MYOF	2041	Q9NZM1