Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	alpha-sialidase activity	NEU4 NEU3	9.94e-05	4	82	2	GO:0016997
GeneOntologyMolecularFunction	exo-alpha-sialidase activity	NEU4 NEU3	9.94e-05	4	82	2	GO:0004308
GeneOntologyBiologicalProcess	regulation of cholangiocyte proliferation	HDAC6 PKHD1 LIMS2	3.34e-06	8	82	3	GO:1904054
GeneOntologyBiologicalProcess	cholangiocyte proliferation	HDAC6 PKHD1 LIMS2	7.12e-06	10	82	3	GO:1990705
GeneOntologyBiologicalProcess	glycosphingolipid catabolic process	NEU4 NEU3 SMPD1	1.15e-04	24	82	3	GO:0046479
GeneOntologyBiologicalProcess	macroautophagy	NPC1 ADCY10 ATG4B HDAC6 RUBCNL TBC1D14 ATP2A2 LIX1	1.20e-04	374	82	8	GO:0016236
GeneOntologyBiologicalProcess	regulation of plasma membrane bounded cell projection organization	ADCY10 NEU4 TRIM67 HDAC6 P2RX4 TBC1D14 GATA3 ARHGAP35 PLXNB2 TENM2 PLXNB3 LRP8	1.24e-04	846	82	12	GO:0120035
GeneOntologyBiologicalProcess	organelle assembly	DNAAF2 DNAAF5 NSUN4 ATG4B MDN1 HDAC6 KIAA0319L TBC1D14 OBSCN PKHD1 UHRF1 ARHGAP35 ATP2A2 HPS3	1.46e-04	1138	82	14	GO:0070925
GeneOntologyBiologicalProcess	regulation of cell projection organization	ADCY10 NEU4 TRIM67 HDAC6 P2RX4 TBC1D14 GATA3 ARHGAP35 PLXNB2 TENM2 PLXNB3 LRP8	1.49e-04	863	82	12	GO:0031344
GeneOntologyBiologicalProcess	glycolipid catabolic process	NEU4 NEU3 SMPD1	1.65e-04	27	82	3	GO:0019377
Domain	EGF_CA	DNER DLK2 DLK1 LTBP4 TENM2 F12 NOTCH3 LRP8	6.26e-08	122	82	8	SM00179
Domain	EGF-like_Ca-bd_dom	DNER DLK2 DLK1 LTBP4 TENM2 F12 NOTCH3 LRP8	7.11e-08	124	82	8	IPR001881
Domain	EGF_1	DNER NTN5 DLK2 DLK1 LTBP4 TENM2 F12 NOTCH3 LRP8	1.76e-06	255	82	9	PS00022
Domain	EGF_2	DNER NTN5 DLK2 DLK1 LTBP4 TENM2 F12 NOTCH3 LRP8	2.42e-06	265	82	9	PS01186
Domain	ASX_HYDROXYL	DNER DLK2 DLK1 LTBP4 NOTCH3 LRP8	5.10e-06	100	82	6	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	DNER DLK2 DLK1 LTBP4 NOTCH3 LRP8	7.15e-06	106	82	6	IPR000152
Domain	EGF_3	DNER DLK2 DLK1 LTBP4 TENM2 F12 NOTCH3 LRP8	8.92e-06	235	82	8	PS50026
Domain	EGF	DNER DLK2 DLK1 LTBP4 TENM2 F12 NOTCH3 LRP8	8.92e-06	235	82	8	SM00181
Domain	EGF-like_dom	DNER DLK2 DLK1 LTBP4 TENM2 F12 NOTCH3 LRP8	1.36e-05	249	82	8	IPR000742
Domain	EGF-like_CS	DNER DLK2 DLK1 LTBP4 TENM2 F12 NOTCH3 LRP8	1.91e-05	261	82	8	IPR013032
Domain	EGF	DNER DLK2 DLK1 F12 NOTCH3 LRP8	1.93e-05	126	82	6	PF00008
Domain	Growth_fac_rcpt_	IGFBP4 DNER FBXL19 LTBP4 NOTCH3 LRP8	6.40e-05	156	82	6	IPR009030
Domain	EGF_Ca-bd_CS	DNER DLK2 LTBP4 NOTCH3 LRP8	6.77e-05	97	82	5	IPR018097
Domain	EGF_CA	DNER DLK2 LTBP4 NOTCH3 LRP8	7.47e-05	99	82	5	PS01187
Domain	Sialidase_fam	NEU4 NEU3	1.14e-04	4	82	2	IPR026856
Domain	BNR_2	NEU4 NEU3	1.14e-04	4	82	2	PF13088
Domain	EGF_extracell	DNER DLK2 DLK1 NOTCH3	1.40e-04	60	82	4	IPR013111
Domain	EGF_2	DNER DLK2 DLK1 NOTCH3	1.40e-04	60	82	4	PF07974
Domain	-	NEU4 NEU3	1.89e-04	5	82	2	2.120.10.10
Domain	IPT	PKHD1 PLXNB2 PLXNB3	2.21e-04	27	82	3	SM00429
Domain	hEGF	DNER DLK2 NOTCH3	2.47e-04	28	82	3	PF12661
Domain	TIG	PKHD1 PLXNB2 PLXNB3	3.36e-04	31	82	3	PF01833
Domain	IPT	PKHD1 PLXNB2 PLXNB3	3.69e-04	32	82	3	IPR002909
Domain	Plexin_cytopl	PLXNB2 PLXNB3	6.72e-04	9	82	2	PF08337
Domain	Plexin_cytoplasmic_RasGAP_dom	PLXNB2 PLXNB3	6.72e-04	9	82	2	IPR013548
Domain	Plexin	PLXNB2 PLXNB3	6.72e-04	9	82	2	IPR031148
Domain	Sialidases	NEU4 NEU3	6.72e-04	9	82	2	IPR011040
Domain	-	ANKFY1 TRIM67 HDAC6 RNF44 RNF38 UHRF1 RNF222 FBXL19	7.89e-04	449	82	8	3.30.40.10
Domain	Znf_RING/FYVE/PHD	ANKFY1 TRIM67 HDAC6 RNF44 RNF38 UHRF1 RNF222 FBXL19	9.10e-04	459	82	8	IPR013083
Pathway	WP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING	DNER DLK2 DLK1 NOTCH3	3.40e-06	27	55	4	M39545
Pathway	WP_DEGRADATION_PATHWAY_OF_SPHINGOLIPIDS_INCLUDING_DISEASES	NPC1 NEU4 NEU3	3.68e-05	17	55	3	M39638
Pathway	PID_NOTCH_PATHWAY	DNER GATA3 DLK1 NOTCH3	8.05e-05	59	55	4	M17
Pathway	REACTOME_GLYCOSPHINGOLIPID_CATABOLISM	NEU4 NEU3 SMPD1	3.09e-04	34	55	3	MM17076
Pathway	REACTOME_SIGNALING_BY_NOTCH	PSMF1 HDAC6 DNER DLK1 ATP2A2 NOTCH3	3.77e-04	246	55	6	M10189
Pathway	REACTOME_GLYCOSPHINGOLIPID_CATABOLISM	NEU4 NEU3 SMPD1	4.65e-04	39	55	3	M48042
Pathway	KEGG_SPHINGOLIPID_METABOLISM	NEU4 NEU3 SMPD1	4.65e-04	39	55	3	M15955
Pubmed	A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.	DNER DLK1 TENM2 GFRA1 LRP8	3.05e-06	91	85	5	28558017
Pubmed	An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration.	P2RX4 PLXNB2 PLXNB3	3.96e-06	13	85	3	24572910
Pubmed	Evidence for mitochondrial localization of a novel human sialidase (NEU4).	NEU4 NEU3	5.90e-06	2	85	2	15847605
Pubmed	Similarities and differences in tissue distribution of DLK1 and DLK2 during E16.5 mouse embryogenesis.	DLK2 DLK1	5.90e-06	2	85	2	30888503
Pubmed	Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease.	NPC1 SMPD1	5.90e-06	2	85	2	7670466
Pubmed	Niemann-Pick disease.	NPC1 SMPD1	5.90e-06	2	85	2	10608504
Pubmed	Comprehensive Evaluation of Plasma 7-Ketocholesterol and Cholestan-3β,5α,6β-Triol in an Italian Cohort of Patients Affected by Niemann-Pick Disease due to NPC1 and SMPD1 Mutations.	NPC1 SMPD1	5.90e-06	2	85	2	26790753
Pubmed	The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling.	NPC1 SMPD1	5.90e-06	2	85	2	8181053
Pubmed	The novel gene EGFL9/Dlk2, highly homologous to Dlk1, functions as a modulator of adipogenesis.	DLK2 DLK1	5.90e-06	2	85	2	17320102
Pubmed	Biochemical, pathological, and clinical response to transplantation of normal bone marrow cells into acid sphingomyelinase-deficient mice.	NPC1 SMPD1	5.90e-06	2	85	2	9565090
Pubmed	Presence of aberrant epididymal tubules revealing undifferentiated epithelial cells and absence of spermatozoa in a combined neuraminidase-3 and -4 deficient adult mouse model.	NEU4 NEU3	5.90e-06	2	85	2	30359429
Pubmed	Mouse models of Niemann-Pick disease: mutation analysis and chromosomal mapping rule out the type A and B forms.	NPC1 SMPD1	5.90e-06	2	85	2	8288255
Pubmed	Integrin-mediated cell migration is blocked by inhibitors of human neuraminidase.	NEU4 NEU3	5.90e-06	2	85	2	27344026
Pubmed	Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease).	NPC1 SMPD1	5.90e-06	2	85	2	7600574
Pubmed	Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells.	HDAC6 NOTCH3	5.90e-06	2	85	2	29643474
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NPC1 MDN1 MCM3AP KIAA0319L OBSCN STRN4 TP53I13 FBXL19 ARHGAP35 ZZEF1 PLXNB2 LTBP4	1.55e-05	1105	85	12	35748872
Pubmed	Human sialidase as a cancer marker.	NEU4 NEU3	1.77e-05	3	85	2	18651674
Pubmed	The Janus-like role of neuraminidase isoenzymes in inflammation.	NEU4 NEU3	1.77e-05	3	85	2	35363389
Pubmed	GATA3, HDAC6, and BCL6 Regulate FOXP3+ Treg Plasticity and Determine Treg Conversion into Either Novel Antigen-Presenting Cell-Like Treg or Th1-Treg.	HDAC6 GATA3	1.77e-05	3	85	2	29434588
Pubmed	A lysosomal storage disorder in mice characterized by a dual deficiency of sphingomyelinase and glucocerebrosidase.	NPC1 SMPD1	1.77e-05	3	85	2	6257302
Pubmed	The proteins DLK1 and DLK2 modulate NOTCH1-dependent proliferation and oncogenic potential of human SK-MEL-2 melanoma cells.	DLK2 DLK1	1.77e-05	3	85	2	25093684
Pubmed	Neuraminidases 3 and 4 regulate neuronal function by catabolizing brain gangliosides.	NEU4 NEU3	1.77e-05	3	85	2	28442549
Pubmed	Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages.	NEU4 NEU3	1.77e-05	3	85	2	15885103
Pubmed	The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells.	NPC1 SMPD1	1.77e-05	3	85	2	37407594
Pubmed	The EGF-like proteins DLK1 and DLK2 function as inhibitory non-canonical ligands of NOTCH1 receptor that modulate each other's activities.	DLK2 DLK1	1.77e-05	3	85	2	21419176
Pubmed	Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin.	PLXNB2 PLXNB3	1.77e-05	3	85	2	16122393
Pubmed	Taking the next step forward - Diagnosing inherited infantile cholestatic disorders with next generation sequencing.	NPC1 PKHD1	1.77e-05	3	85	2	25771912
Pubmed	The Reelin receptors ApoER2 and VLDLR are direct target genes of HIC1 (Hypermethylated In Cancer 1).	HIC1 LRP8	1.77e-05	3	85	2	24076391
Pubmed	Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis.	NPC1 SMPD1	1.77e-05	3	85	2	16950136
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	NPC1 IGFBP4 KIAA0319L DNER UHRF1 SMPD1 CKAP2 ZZEF1 PLXNB2 ATP2A2 NOTCH3 LRP8	3.51e-05	1201	85	12	35696571
Pubmed	Significance of NF-kappaB/GATA axis in tumor necrosis factor-alpha-induced expression of 6-sulfated cell recognition glycans in human T-lymphocytes.	GATA3 CHST6	3.53e-05	4	85	2	18849568
Pubmed	Plexin-B family members demonstrate non-redundant expression patterns in the developing mouse nervous system: an anatomical basis for morphogenetic effects of Sema4D during development.	PLXNB2 PLXNB3	3.53e-05	4	85	2	15147296
Pubmed	The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2.	MAPK8IP2 LRP8	3.53e-05	4	85	2	10827199
Pubmed	Grb2 mediates semaphorin-4D-dependent RhoA inactivation.	ARHGAP35 PLXNB2	3.53e-05	4	85	2	22505611
Pubmed	Developmental change of sialidase neu4 expression in murine brain and its involvement in the regulation of neuronal cell differentiation.	NEU4 NEU3	3.53e-05	4	85	2	19506080
Pubmed	The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer.	GAD2 GATA3 DLK1 GFRA1	3.54e-05	75	85	4	37298722
Pubmed	Notch signaling in stomach epithelial stem cell homeostasis.	DLK2 DLK1 NOTCH3	4.92e-05	29	85	3	21402740
Pubmed	RhoA/ROCK activation by growth hormone abrogates p300/histone deacetylase 6 repression of Stat5-mediated transcription.	HDAC6 ARHGAP35	5.87e-05	5	85	2	15102857
Pubmed	Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF.	PLXNB2 PLXNB3	5.87e-05	5	85	2	12183458
Pubmed	Interplay between scatter factor receptors and B plexins controls invasive growth.	PLXNB2 PLXNB3	5.87e-05	5	85	2	15184888
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	IPPK MDN1 MCM3AP TBC1D14 OBSCN PKHD1 AMER3 ZZEF1 PLXNB3	7.96e-05	736	85	9	29676528
Pubmed	Apolipoprotein E controls ATP-binding cassette transporters in the ischemic brain.	MAPK8IP2 LRP8	1.23e-04	7	85	2	20923933
Pubmed	The expression of plexins during mouse embryogenesis.	PLXNB2 PLXNB3	1.64e-04	8	85	2	15661641
Pubmed	Dlk1 is a negative regulator of emerging hematopoietic stem and progenitor cells.	GATA3 DLK1	1.64e-04	8	85	2	22801971
Pubmed	Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.	ANKFY1 ZZEF1	1.64e-04	8	85	2	24039173
Pubmed	Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase.	HK3 IGFBP4	1.64e-04	8	85	2	11068878
Pubmed	Reduced salivary gland size and increased presence of epithelial progenitor cells in DLK1-deficient mice.	DLK2 DLK1	2.10e-04	9	85	2	26711912
Pubmed	SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart.	ALAS2 ATP2A2	2.62e-04	10	85	2	19386262
Pubmed	GDNF and GFRalpha1 promote differentiation and tangential migration of cortical GABAergic neurons.	GAD2 GFRA1	2.62e-04	10	85	2	15748846
Pubmed	gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis.	GATA3 NOTCH3	2.62e-04	10	85	2	15525534
Pubmed	p62/sequestosome 1 binds to TDP-43 in brains with frontotemporal lobar degeneration with TDP-43 inclusions.	ATG4B HDAC6	2.62e-04	10	85	2	22674379
Pubmed	Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex.	IGFBP4 PLXNB2 LIX1 PLXNB3	2.65e-04	126	85	4	16284245
Pubmed	An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.	NTN5 PLXNB2 PLXNB3	2.86e-04	52	85	3	26633812
Pubmed	Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.	IGFBP4 LCORL AMZ1 TMEM176A	2.90e-04	129	85	4	23563607
Pubmed	The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1.	RNF44 RNF38	3.20e-04	11	85	2	28536267
Pubmed	Reelin signaling is necessary for a specific step in the migration of hindbrain efferent neurons.	GATA3 LRP8	3.20e-04	11	85	2	15703280
Pubmed	Lim 1 is required for nephric duct extension and ureteric bud morphogenesis.	GATA3 GFRA1	3.20e-04	11	85	2	16216236
Pubmed	A null allele of Dnaaf2 displays embryonic lethality and mimics human ciliary dyskinesia.	DNAAF2 DNAAF5	3.83e-04	12	85	2	31107948
Pubmed	Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology.	PLXNB2 PLXNB3	3.83e-04	12	85	2	12123608
Pubmed	A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system.	PLXNB2 PLXNB3	3.83e-04	12	85	2	20478304
Pubmed	Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.	PLXNB2 PLXNB3	3.83e-04	12	85	2	21270798
Pubmed	A Point Mutation in p190A RhoGAP Affects Ciliogenesis and Leads to Glomerulocystic Kidney Defects.	GATA3 ARHGAP35	4.52e-04	13	85	2	26859289
Pubmed	Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.	PLXNB2 PLXNB3	4.52e-04	13	85	2	10520995
Pubmed	Multifaceted Hoxa13 function in urogenital development underlies the Hand-Foot-Genital Syndrome.	GATA3 GFRA1	4.52e-04	13	85	2	30649340
Pubmed	Single-nucleus RNA sequencing of developing superior colliculus identifies neuronal diversity and candidate mediators of circuit assembly.	GAD2 GFRA1	4.52e-04	13	85	2	37624694
Pubmed	Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases.	CAND2 FBXL8 FBXL19	4.80e-04	62	85	3	29103612
Pubmed	Molecular Profiling of the Developing Lacrimal Gland Reveals Putative Role of Notch Signaling in Branching Morphogenesis.	DLK1 NOTCH3	5.27e-04	14	85	2	28192800
Pubmed	E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3.	MCM3AP LTBP4	6.07e-04	15	85	2	18276110
Pubmed	Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development.	PLXNB2 PLXNB3	6.07e-04	15	85	2	21122816
Pubmed	Critical role of GFRα1 in the development and function of the main olfactory system.	GAD2 GFRA1	6.07e-04	15	85	2	23197722
Pubmed	EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos.	UHRF1 TENM2	6.07e-04	15	85	2	26576615
Pubmed	Enhancer Variants Synergistically Drive Dysfunction of a Gene Regulatory Network In Hirschsprung Disease.	GATA3 GFRA1	6.93e-04	16	85	2	27693352
Pubmed	Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.	PLXNB2 PLXNB3	7.84e-04	17	85	2	11683995
Pubmed	Segmental expression of Notch and Hairy genes in nephrogenesis.	DLK1 NOTCH3	7.84e-04	17	85	2	15821257
Pubmed	Semaphorin signaling facilitates cleft formation in the developing salivary gland.	PLXNB2 PLXNB3	7.84e-04	17	85	2	17626059
Pubmed	REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain.	GAD2 TRIM67	8.80e-04	18	85	2	28049845
Pubmed	Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.	MAPK8IP2 LRP8	8.80e-04	18	85	2	10827173
Pubmed	Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice.	GAD2 NEURL4	9.83e-04	19	85	2	37389991
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	ARFGEF3 CAND2 MAGED4 PLXNB2 NEURL4	1.04e-03	313	85	5	38270169
Pubmed	Retinoic Acid Receptor β Controls Development of Striatonigral Projection Neurons through FGF-Dependent and Meis1-Dependent Mechanisms.	GAD2 DLK1	1.09e-03	20	85	2	26511239
Pubmed	Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing.	DLK2 PLXNB3	1.09e-03	20	85	2	31291246
Pubmed	Identifying the molecular phenotype of renal progenitor cells.	DNAAF2 GATA3	1.09e-03	20	85	2	15339983
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	NPC1 GAD2 HDAC6 KIAA0319L DNER RNF38 CKAP2 ATP2A2 PLXNB3 MAPK8IP2	1.16e-03	1285	85	10	35914814
Pubmed	Canonical notch signaling functions as a commitment switch in the epidermal lineage.	GATA3 NOTCH3	1.20e-03	21	85	2	17079689
Pubmed	Genome-wide diet-gene interaction analyses for risk of colorectal cancer.	LCORL GATA3	1.20e-03	21	85	2	24743840
Pubmed	Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population.	MUC5B DLK1	1.32e-03	22	85	2	12768436
Pubmed	Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney.	PLXNB2 GFRA1	1.44e-03	23	85	2	21035938
Pubmed	Genomic variants in an inbred mouse model predict mania-like behaviors.	OBSCN HPS3	1.44e-03	23	85	2	29768498
Pubmed	TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction.	DLK1 NOTCH3	1.57e-03	24	85	2	24487590
Pubmed	A genomic atlas of mouse hypothalamic development.	GAD2 DLK1 TENM2 GFRA1	1.64e-03	205	85	4	20436479
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	ATG4B HDAC6 LCORL MCM3AP TBC1D14 SMPD1 PLXNB2 NOTCH3 MAPK8IP2	1.70e-03	1124	85	9	21900206
Pubmed	Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development.	GAD2 DLK1	1.71e-03	25	85	2	30718509
Pubmed	HNF1B controls epithelial organization and cell polarity during ureteric bud branching and collecting duct morphogenesis.	PKHD1 GFRA1	1.71e-03	25	85	2	29158444
Pubmed	Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics.	OBSCN ATP2A2	1.71e-03	25	85	2	38877142
Pubmed	Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons.	GAD2 GATA3	1.71e-03	25	85	2	19088086
Pubmed	Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning.	DLK1 NOTCH3	1.85e-03	26	85	2	25446530
Pubmed	Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon.	GAD2 NOTCH3	1.85e-03	26	85	2	12397111
Pubmed	NPC1 is required for postnatal islet β cell differentiation by maintaining mitochondria turnover.	NPC1 DLK1	1.99e-03	27	85	2	38505613
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ARFGEF3 ANKFY1 PLXNB3	2.09e-03	103	85	3	10574462
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	ARFGEF3 MDN1 MCM3AP	2.15e-03	104	85	3	31240132
Interaction	MAP1LC3B2 interactions	NPC1 ATG4B TRIM67 HDAC6	1.04e-06	19	84	4	int:MAP1LC3B2
Interaction	HPS3 interactions	ARMC5 KLHL34 C9orf163 F12 HPS3	1.20e-06	45	84	5	int:HPS3
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	HIC1 ANKFY1 RNF222 ZZEF1 NEURL4	4.73e-04	346	85	5	chr17p13
Cytoband	1p34	NSUN4 LRP8	1.62e-03	32	85	2	1p34
Cytoband	5q35.2	HK3 RNF44	1.62e-03	32	85	2	5q35.2
Cytoband	7p22.3	DNAAF5 AMZ1	1.83e-03	34	85	2	7p22.3
Cytoband	22q13.33	PLXNB2 MAPK8IP2	2.28e-03	38	85	2	22q13.33
GeneFamily	Plexins	PLXNB2 PLXNB3	2.35e-04	9	47	2	683
GeneFamily	Ring finger proteins	TRIM67 RNF44 RNF38 UHRF1 RNF222	7.14e-04	275	47	5	58
GeneFamily	F-box and leucine rich repeat proteins	FBXL8 FBXL19	1.35e-03	21	47	2	558
GeneFamily	Tudor domain containing	TDRD15 UHRF1	4.16e-03	37	47	2	780
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	HIC1 ANKFY1 KLHL34	5.09e-03	134	47	3	861
Coexpression	THAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_28DY_DN	GPR137 DNAAF5 ATG4B HK3 SHFL RNF44 MCM3AP KIAA0319L TMEM176A TP53I13 ZZEF1 PLXNB2 ATP2A2 LTBP4	1.21e-06	905	85	14	M40865
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma\|TCGA-Brain / Sample_Type by Project: Shred V9	ARFGEF3 TRIM67 AMZ1 DGKK AMER3 GFRA1	6.17e-07	161	84	6	5f6b2d7f80a8ee16651e304481d2da3fae313824
ToppCell	facs-Heart-RV-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFBP4 DLK1 SLC22A7 F12 GFRA1 ACOX2	7.65e-07	167	84	6	3e3d8f6df2feefafad5b44ba0ebf5b5a0fe4ed58
ToppCell	facs-Heart-RV-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFBP4 DLK1 SLC22A7 F12 GFRA1 ACOX2	7.65e-07	167	84	6	3ad9f3122dbe96580f640388ef920ea209fc2349
ToppCell	droplet-Marrow-nan-18m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAND2 FNDC10 NEU3 ARHGAP35 ZZEF1 PLXNB2	9.72e-07	174	84	6	55cc8300489d11322724159ec7d0e1d32a702e91
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARFGEF3 TRIM67 DGKK DNER AMER3 MAPK8IP2	1.57e-06	189	84	6	cceca3d14dd559bbb2cb4b81ea12c2b62d18ee49
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P2-Tnr\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NEU4 MUC5B CKAP2 PLXNB3 LIMS2	2.11e-06	110	84	5	b9c8014fd2820e5ea28a7e02fd24227b99e71eb3
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NEU4 MUC5B CKAP2 PLXNB3 LIMS2	2.11e-06	110	84	5	ee45592e936d32881c0f3429c21360670e5b3ce3
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NEU4 AMZ1 DNER GFRA1 PLXNB3 LIMS2	2.12e-06	199	84	6	333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NEU4 AMZ1 DNER GFRA1 PLXNB3 LIMS2	2.12e-06	199	84	6	e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NEU4 AMZ1 DNER GFRA1 PLXNB3 LIMS2	2.18e-06	200	84	6	ad777683adeb2ce45ade570386235e311fa7ea2d
ToppCell	LPS-antiTNF-Lymphocytic_NKT-T_cells-Erythroid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAAF5 STRN4 CKAP2 LIX1 F12	4.11e-06	126	84	5	54247ce9ee0a4f123f1fb225600a4ec698510a86
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-2\|TCGA-Brain / Sample_Type by Project: Shred V9	TRIM67 AMZ1 DGKK NEU3 GFRA1	4.28e-06	127	84	5	018ffd9ff1913787cb0086a8581b399a121eaba1
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Thalamus / BrainAtlas - Mouse McCarroll V32	ADCY10 GAD2 DGKK GATA3 DLK1	9.01e-06	148	84	5	afebb64365c94b9476494bffe7c364677f19c8cf
ToppCell	Thalamus-Neuronal-Inhibitory\|Thalamus / BrainAtlas - Mouse McCarroll V32	ADCY10 GAD2 DGKK GATA3 DLK1	9.01e-06	148	84	5	5f82e5ecacfd223020b8ee975c17d68c1fe6db38
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARFGEF3 TRIM67 MAGED4 RUBCNL GFRA1	1.44e-05	163	84	5	99cf60dc87f7ce288553091bffcd85109a02bd8f
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor-Neuroblast\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARFGEF3 TRIM67 MAGED4 RUBCNL GFRA1	1.44e-05	163	84	5	510c0af66e82c5a8cf8edd0547dae4018a87dbbf
ToppCell	LPS-antiTNF-Endothelial-Mes-Like-Alv_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAAF2 ANKFY1 STRN4 PGLS ACOX2	1.57e-05	166	84	5	94a00edf66d54bc5f7343daea700ca26cf38fd90
ToppCell	3'_v3-Lung-Myeloid_Mac-Intestinal_macrophages\|Lung / Manually curated celltypes from each tissue	IGFBP4 TBC1D14 C3orf70 TMEM176A CALHM6	1.71e-05	169	84	5	241644823e6f949aaf4c671d4579721d7ef6b0e5
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Tmsb4x_(Tmsb4x)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NEU4 MUC5B CKAP2 SLC22A7	2.14e-05	86	84	4	db67c05c876a5649371c0dc6c941cc371bc2feb8
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Tmsb4x_(Tmsb4x)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NEU4 MUC5B CKAP2 SLC22A7	2.14e-05	86	84	4	2778446e035c5585bce28ed0ef93b87b6ad90c6e
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B-Branch_B2_(eMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARFGEF3 HK3 DNER LIX1 MAPK8IP2	2.26e-05	179	84	5	d96741c5c551e36421b2ad938072ab7d506c3835
ToppCell	Club-club-8\|World / Class top	IGFBP4 P2RX4 NTN5 MUC5B TMEM213	2.44e-05	182	84	5	8111d917e588008d947021460ddf8f1e7ae1337a
ToppCell	(00)_Basal-(0)_uninjured\|(00)_Basal / shred by cell type and Timepoint	DLK2 TMEM176A MUC5B LTBP4 GFRA1	2.44e-05	182	84	5	c02c9cab4389d80f318f4bb8d703c1e719672624
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 DGKK OBSCN PKHD1 MUC5B	2.57e-05	184	84	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-5_PVALB_TRIM67\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAD2 TRIM67 DNER PKHD1 LRP8	2.57e-05	184	84	5	7f6c8912677764d438ab0555faca344d74c2f483
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B-Branch_B3_(IPAN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRIM67 DNER LIX1 F12 MAPK8IP2	2.57e-05	184	84	5	abb61e744a9031e0c91eb560a8f486a0ca5a01cc
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 DGKK OBSCN PKHD1 MUC5B	2.57e-05	184	84	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 DGKK OBSCN PKHD1 MUC5B	2.57e-05	184	84	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAD2 TRIM67 RUBCNL DNER LRP8	2.71e-05	186	84	5	948815663c212c4311329d503b5991cbbbff9808
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.4.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGFBP4 TMEM176A DLK1 LTBP4 GFRA1	2.71e-05	186	84	5	07d94d5d1c2fe7bb909a07ca81058a0eabc65c60
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAD2 TRIM67 DNER PKHD1 LRP8	2.78e-05	187	84	5	85f1678338a47d91e296f0620d4887f057eb7e70
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAD2 TRIM67 RUBCNL DNER LRP8	2.85e-05	188	84	5	72cbfe9dc0583dbeafa6cb0945fa370d0c808284
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAD2 TRIM67 RUBCNL DNER LRP8	2.85e-05	188	84	5	8de5a07301f9b5984680c873e5a92395b5ed3dd3
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAD2 TRIM67 RUBCNL DNER LRP8	2.93e-05	189	84	5	78cf414b98bcb19deb934409acddaad1cd51b67f
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARFGEF3 DNER LIX1 F12 MAPK8IP2	3.00e-05	190	84	5	bdbfaced785db79ff965f332759be258dbf743cf
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEU4 TRIM67 AMZ1 DNER TMEM176A	3.00e-05	190	84	5	9b825b2586c7b173ff27fcf2abc5860faf50984a
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEU4 TRIM67 AMZ1 DNER TMEM176A	3.00e-05	190	84	5	d146af1926474328a7c822bc140c4dda66e1bbfb
ToppCell	E15.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HIC1 IGFBP4 DLK1 LTBP4 TENM2	3.08e-05	191	84	5	053b3664f509baa107feaf90730f80ebf9ac8f14
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEU4 TRIM67 AMZ1 DNER TMEM176A	3.08e-05	191	84	5	ece87127f85939e61b1048d968ed96f0e87c3a79
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEU4 TRIM67 AMZ1 DNER TMEM176A	3.08e-05	191	84	5	478e8341ee03b05501e2233e02cef5f97492c95d
ToppCell	11.5-Airway-Epithelial-Epithelial\|Airway / Age, Tissue, Lineage and Cell class	GATA3 TMEM176A AMER3 F12 MAPK8IP2	3.16e-05	192	84	5	a77d3692ff02ef7e066a9bd9e22725055a25c4d4
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GATA3 TMEM176A CHST6 PLXNB2 TMEM213	3.16e-05	192	84	5	967122c53af25b8f19a8411b4553d764c8d51c4d
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARFGEF3 DNER LIX1 F12 MAPK8IP2	3.32e-05	194	84	5	15224fb3e7ca5bd1fb8c41f8275842f737014095
ToppCell	TCGA-Adrenal-Primary_Tumor-Pheochromocytoma\|TCGA-Adrenal / Sample_Type by Project: Shred V9	ARFGEF3 DGKK GATA3 AMER3 MAPK8IP2	3.32e-05	194	84	5	b6488bc3a8905e926ad298332963e1bbaf010046
ToppCell	TCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma\|TCGA-Adrenal / Sample_Type by Project: Shred V9	ARFGEF3 DGKK GATA3 AMER3 MAPK8IP2	3.32e-05	194	84	5	1e1f4139ad584f493d75a9b7f1568eca4653c5a2
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGFBP4 C3orf70 DLK1 GFRA1 LIMS2	3.40e-05	195	84	5	bd7526dd80a60ff7bc866e4f5a0e8acdbc10d191
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGFBP4 C3orf70 DLK1 GFRA1 LIMS2	3.40e-05	195	84	5	8a04f0e92d10a368ccda5f566ae67ef51f1d34a9
ToppCell	343B-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	IGFBP4 TBC1D14 TMEM176A UHRF1 CALHM6	3.40e-05	195	84	5	67b05a0cd2ca9924eca81a92cc6330eecb9d963c
ToppCell	Outlier-Outlier-Outlier-Outlier-32\|World / Primary Cells by Cluster	TP53I13 UHRF1 DLK1 ALAS2 LIX1	3.48e-05	196	84	5	433ee89d5451d14a42a4c54b85006bd71884486a
ToppCell	Outlier-Outlier\|World / Primary Cells by Cluster	TP53I13 UHRF1 DLK1 ALAS2 LIX1	3.48e-05	196	84	5	c1d0f8e77a75cbd04d1df18ae7162ac463acfc4c
ToppCell	Outlier-Outlier-Outlier-Outlier\|World / Primary Cells by Cluster	TP53I13 UHRF1 DLK1 ALAS2 LIX1	3.48e-05	196	84	5	2a6ee499cbedcc1ffeb94739d3498207661add33
ToppCell	Outlier\|World / Primary Cells by Cluster	TP53I13 UHRF1 DLK1 ALAS2 LIX1	3.48e-05	196	84	5	62f121878334afa43af60cedcb785035d19caff2
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Adventitial_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	IGFBP4 DNER DLK1 LTBP4 GFRA1	3.48e-05	196	84	5	eed9fe83ffc1f79493b70778962a671dd9f481e0
ToppCell	Outlier-Outlier-Outlier\|World / Primary Cells by Cluster	TP53I13 UHRF1 DLK1 ALAS2 LIX1	3.48e-05	196	84	5	875fc18ca52633f1a53fd17ffeafc59803aec97d
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRIM67 DNER AMER3 LIX1 MAPK8IP2	3.57e-05	197	84	5	27c044833e471a312a572e0b1c83e4bc8a36e896
ToppCell	11.5-Airway-Mesenchymal-Mesenchyme_SERPINF1-high\|Airway / Age, Tissue, Lineage and Cell class	IGFBP4 DNER DLK1 LTBP4 GFRA1	3.57e-05	197	84	5	9a053a32ff9c3a85ef9a3382453acd619cc48546
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARFGEF3 TRIM67 DGKK DNER MAPK8IP2	3.65e-05	198	84	5	50504a3871f76d6a5b439a56450d7770f4501eb0
ToppCell	10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma-muscle_stem_cell\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	DLK1 LTBP4 LIX1 GFRA1 NOTCH3	3.65e-05	198	84	5	55e583321f60c95898d93cd0d2615c6692db52ec
ToppCell	10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	DLK1 LTBP4 LIX1 GFRA1 NOTCH3	3.74e-05	199	84	5	e19b296d583f8bad3b66ee998a8153634d6fe09e
ToppCell	wk_15-18-Mesenchymal-Fibroblast-Adventitial_fibro\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	IGFBP4 DNER DLK1 LTBP4 GFRA1	3.74e-05	199	84	5	8de6d7b2067b22cb9b5f01aa56a3803aebc4406d
ToppCell	10x3'2.3-week_17-19-Mesenchymal_myocytic\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	DLK1 LTBP4 LIX1 GFRA1 NOTCH3	3.74e-05	199	84	5	801887db51ac5dc5b068808ff75e3a46643398e9
ToppCell	wk_20-22-Mesenchymal-Fibroblast-Adventitial_fibro\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	IGFBP4 DNER DLK1 LTBP4 GFRA1	3.74e-05	199	84	5	ab0589c068c24aa989bdca083504fbad0c15221d
ToppCell	distal-Hematologic-EREG+_Dendritic-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NEU4 TMEM176A CALHM6 ZZEF1 ATP2A2	3.83e-05	200	84	5	7809c74a2e52768854b66a135522138281bc4449
ToppCell	Cerebellum-Macroglia-POLYDENDROCYTE-P1-P1_1\|Cerebellum / BrainAtlas - Mouse McCarroll V32	NEU4 DLK2 GFRA1 PLXNB3	8.67e-05	123	84	4	e0eb95f1da12687230b47f0a7367b6138bc7ff1a
ToppCell	Cerebellum-Macroglia-POLYDENDROCYTE-P1\|Cerebellum / BrainAtlas - Mouse McCarroll V32	NEU4 DLK2 GFRA1 PLXNB3	8.67e-05	123	84	4	356e2b1b47fdfc2bb2fcd45e44b452fe811f0fd8
ToppCell	Cerebellum-Macroglia-POLYDENDROCYTE-P1-P1_1-Polydendrocyte.Tnr.Tnr_(Tnr)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	NEU4 DLK2 GFRA1 PLXNB3	8.67e-05	123	84	4	b06a38d1081b4485b519853d8c9a2cddfb1e9e75
ToppCell	Cerebellum-Macroglia-POLYDENDROCYTE-P1-P1_1-Polydendrocyte.Tnr.Tnr_(Tnr)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	NEU4 DLK2 GFRA1 PLXNB3	8.67e-05	123	84	4	f60c1dd89da0e204f73772fe0c319eeca82e7e8a
ToppCell	Cerebellum-Macroglia-POLYDENDROCYTE\|Cerebellum / BrainAtlas - Mouse McCarroll V32	NEU4 DLK2 GFRA1 PLXNB3	8.67e-05	123	84	4	15f951b4eb2f39888e51e1af18c329953d253f7f
ToppCell	primary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-OPC_Pdgfra_Ccnb1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NEU4 UHRF1 CKAP2 PLXNB3	1.04e-04	129	84	4	ff74d159034a09f7b174da18bfb9a26936252b4c
ToppCell	frontal_cortex-Non-neuronal-oligodendrocyte-Oligo-OPC_Pdgfra_Grm5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NEU4 TMEM176A PLXNB3 LIMS2	1.17e-04	133	84	4	63d2f096ae47d9b587acc6c5fbd346e5e58842b8
ToppCell	Control-Epithelial_alveolar-AT_1-Differentiating_AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NEU3 FBXL19 NEURL4 TMEM213	1.35e-04	138	84	4	611fe0fb284e12678f9c47a0bdbfc367a93c52b3
ToppCell	primary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-OPC_Pdgfra_Grm5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NEU4 TMEM176A PLXNB3 LIMS2	1.39e-04	139	84	4	a957ea4e581646c76b16b6a7f89579b8c7ac35b6
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Ttn_(Neuron.Gad1Gad2.Ttn)\|Thalamus / BrainAtlas - Mouse McCarroll V32	ADCY10 GATA3 KLHL34	1.62e-04	56	84	3	cc072782b296e75e1bb11e62d280ca199b73481e
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Ttn_(Neuron.Gad1Gad2.Ttn)--\|Thalamus / BrainAtlas - Mouse McCarroll V32	ADCY10 GATA3 KLHL34	1.62e-04	56	84	3	0c137f6263626df9837e5c00fa6ba6201bfebf52
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Ttn_(Neuron.Gad1Gad2.Ttn)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	ADCY10 GATA3 KLHL34	1.62e-04	56	84	3	435fdc82c2c078e5f37a60de36ce80ca0c3aade8
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	NEU4 LCORL CKAP2 PLXNB3	1.68e-04	146	84	4	a317f14a1aab11ffcce65baeb1c475c04324315f
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1-Excitatory_Neuron.Slc17a7.Reln_(Medial_entorrhinal_cortexm,_Reln+/Cbln1+)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ADCY10 OBSCN SLC22A7	2.09e-04	61	84	3	5e855b5462f42b7a1d0bbd518cc11072342ce0cc
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1-Excitatory_Neuron.Slc17a7.Reln_(Medial_entorrhinal_cortexm,_Reln+/Cbln1+)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ADCY10 OBSCN SLC22A7	2.09e-04	61	84	3	2fc13475581431f82e0b5ef42e18cd29c9787666
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DNAAF5 GATA3 AMER3 CKAP2	2.11e-04	155	84	4	5687416773809b8c478567bc54310af102b3029a
ToppCell	facs-Heart-RA-24m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIM67 OBSCN ALAS2 TMEM213	2.22e-04	157	84	4	9021900d9b1a71210c9c414a9d165eaf399eb607
ToppCell	facs-Heart-RA-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIM67 OBSCN ALAS2 TMEM213	2.22e-04	157	84	4	c8c627ca181856cd31dba4cf073c2be659a49dc1
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Enterocyte_(Proximal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY10 DLK2 CALHM6 ACOX2	2.33e-04	159	84	4	709b57f992a29878cc899d760d144d36cb5cb280
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TMEM176A MUC5B GFRA1 TMEM213	2.44e-04	161	84	4	c4970501c038ed36de447da70eabff020ad78713
ToppCell	PCW_13-14-Neuronal-Neuronal_postreplicative-neuro_immature_neuronal_(2)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	GAD2 AMER3 C9orf163 MAPK8IP2	2.44e-04	161	84	4	bb9cb42882aaa4a1ecf9b480c0e7ac302f2c0d5d
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARFGEF3 AMZ1 MUC5B TMEM213	2.44e-04	161	84	4	7c9d4410d7142a5f3a05418c994f69978c9ffa17
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-Secretory\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TMEM176A MUC5B GFRA1 TMEM213	2.44e-04	161	84	4	41a89a3d99a9bd6039a3d881d1d9dcd18bc07f25
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TRIM67 SHFL ASB16 UHRF1	2.50e-04	162	84	4	3f264263878af630921911c2b344ac56eb1e7099
ToppCell	severe-unassigned\|severe / disease stage, cell group and cell class	IGFBP4 NEURL4 F12 LIMS2	2.68e-04	165	84	4	f9ddd547992fec065d539a1d0305acba8fc7d79c
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARFGEF3 GAD2 AMER3 MAPK8IP2	2.74e-04	166	84	4	f0912ce0df5ede3bc5e7c99ccfe4decc16c6064e
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NEU4 CKAP2 PLXNB3 LIMS2	2.74e-04	166	84	4	a7ac5a414e3e2ff01f1c452c0a85048b17cba0b6
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD2 DGKK DLK1 AMER3	2.74e-04	166	84	4	548d0d6c0ffd564036ddba78620734220ebb73d7
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD2 DGKK DLK1 AMER3	2.74e-04	166	84	4	80e164a89d22098cabe4a99a78283ba69ea0561e
ToppCell	Dividing_Macrophages-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	NEU4 AMZ1 UHRF1 CKAP2	2.74e-04	166	84	4	ea95b94ccc2ac67df741b30c27f4ae698925875f
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE\|Thalamus / BrainAtlas - Mouse McCarroll V32	NEU4 LCORL CKAP2 PLXNB3	2.80e-04	167	84	4	1e144c03409df94ccd39760842590e8ea7487e29
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IGFBP4 DNER OBSCN TMEM176A	2.87e-04	168	84	4	d2b91f2adc95dcfa623f8d7ca2df1c6f884da988
ToppCell	droplet-Spleen-nan-21m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPC1 OBSCN NOTCH3 LRP8	2.93e-04	169	84	4	7962165cab84af73d20b56eb70b1ed87c94025ef
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	NEU4 CKAP2 PLXNB3 LIMS2	2.93e-04	169	84	4	50cc0f5a022b95986949db63208a627cef9f4a69
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-Pulmonary_NE_precursor\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ARFGEF3 DGKK TMEM176A AMER3	3.00e-04	170	84	4	98d13dbd76a826e47d55553f9d11f71c043b573e
ToppCell	droplet-Spleen-nan-18m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPC1 OBSCN NOTCH3 LRP8	3.07e-04	171	84	4	4e856441063e9825b6f87a1d3dd19c77dae4662c
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-6\|TCGA-Bladder / Sample_Type by Project: Shred V9	IPPK TENM2 F12 LRP8	3.07e-04	171	84	4	0e78389f8f3d54570a6deb3dd307b865b46307e9
Disease	Sphingomyelin/cholesterol lipidosis	NPC1 SMPD1	2.17e-05	3	80	2	cv:C0028064
Disease	Niemann-Pick disease (implicated_via_orthology)	NPC1 SMPD1	4.34e-05	4	80	2	DOID:14504 (implicated_via_orthology)
Disease	visceral adipose tissue measurement	NPC1 FNDC10 LCORL DNER PKHD1 DLK1 ZZEF1	3.34e-04	481	80	7	EFO_0004765
Disease	diet measurement, colorectal cancer	LCORL GATA3	1.20e-03	19	80	2	EFO_0008111, MONDO_0005575
Disease	cardiac troponin I measurement	CAND2 LCORL PLXNB2 F12	1.36e-03	176	80	4	EFO_0010071
Disease	hematocrit	TDRD15 ATXN7L3 ANKFY1 ASB16 AMZ1 DGKK PKHD1 TMEM176A LTBP4	1.65e-03	1011	80	9	EFO_0004348
Disease	vital capacity	HIC1 CAND2 LCORL AMZ1 DNER UHRF1 ZZEF1 ATP2A2 LTBP4 TENM2	1.84e-03	1236	80	10	EFO_0004312
Disease	lymphocyte count	IPPK GAD2 LCORL AMZ1 MCM3AP TBC1D14 DNER GATA3 PLXNB2 NEURL4 LIMS2	1.94e-03	1464	80	11	EFO_0004587

Protein segments in the cluster

Peptide	Gene	Start	Entry
SASAPECRCSLLARE	AMER3	826	Q8N944
DLARCPAQRAADFLC	ACOX2	481	Q99424
CLPSVAAASIRCSSR	AMZ1	131	Q400G9
VAQRAACCLAGARAR	PGLS	26	O95336
CAQLSARADSPALCR	SMPD1	596	P17405
RAAAFLCCSFQRAGA	C9orf163	16	Q8N9P6
AAAQQCRSRRCPSSP	ASB16	31	Q96NS5
SRLTCNPACLEAFVR	ARMC5	571	Q96C12
SLCPFVNIPCAAARA	ADCY10	671	Q96PN6
AQALARSCAARRPDF	C3orf70	21	A6NLC5
DRDVRACSSAPCANN	DLK1	86	P80370
CPNCSRSIAASRFAP	ATXN7L3	86	Q14CW9
RLCRTSVPCAGATAF	ATG4B	181	Q9Y4P1
ETDAFVCRPNAALCR	CKAP2	661	Q8WWK9
SCRQLSPEACARLAA	FBXL19	661	Q6PCT2
ACANARNSFEDPCSL	MUC5B	596	Q9HC84
CTASATAAAARCPRA	MUC5B	5121	Q9HC84
FQSSECPRCARITAR	RUBCNL	636	Q9H714
CVCSSQASPAPRAAA	TP53I13	281	Q8NBR0
CNLDRAASLCLPRYS	P2RX4	261	Q99571
RVCEASPFSRSLRCQ	IPPK	291	Q9H8X2
ACFLIRSGCDVNSPR	ANKFY1	741	Q9P2R3
SQPPRAAARKAACAC	GAD2	61	Q05329
CNVCRESIPALSRDA	DGKK	341	Q5KSL6
LAPENCCFAANVAAR	KLHL34	126	Q8N239
TLCRALRFAASNPCG	MDN1	966	Q9NU22
ANAVCQRCQARFSPA	LIMS2	11	Q7Z4I7
SSACAFSQAPCAREV	MAGED4	206	Q96JG8
SLDGARRCFVNVCSN	DNAAF2	81	Q9NVR5
AAALCASERRCSPLC	HIC1	226	Q14526
IQADCSRPQSCRAFR	KIAA0319L	106	Q8IZA0
AACLCLVARRAPSTS	GPR137	191	Q96N19
AAAAAAAQCRSPRCA	LCORL	16	Q8N3X6
AAQCRSPRCAAERRG	LCORL	21	Q8N3X6
APCCVDVSDRLRALA	MCM3AP	1266	O60318
AARPGRACSAACSEE	MAPK8IP2	456	Q13387
SFGRSDCSLCRAANP	PLXNB2	761	O15031
CSAVQALEAAAPCRA	PLXNB3	621	Q9ULL4
QSLARDACESQPCRA	NOTCH3	731	Q9UM47
ATGRNAARLCCVASR	NEU4	116	Q8WWR8
VCTRAAQLCAAALAA	HK3	391	P52790
PLQDVSVAACNFCRR	ALAS2	546	P22557
FQCCLSRAEARRDAA	LIX1	81	Q8N485
CCRNLAANDLSPSRI	NSUN4	196	Q96CB9
FCNASVVDPACVRCR	NPC1	966	O15118
AAVRAGAQACFTCTL	OBSCN	4441	Q5VST9
RLSAARRAGTSCANC	GATA3	306	P23771
NPSAQRDACLNARCF	ATP2A2	661	P16615
CRSRLADFFTNCQPE	GFRA1	256	P56159
ERIFSAVAFQCPCSA	CALHM6	31	Q5R3K3
CAATGSAAFAQRLCL	CALHM6	126	Q5R3K3
LLALRCACPEDARAS	FBXL8	221	Q96CD0
APAAARRVRAFALNC	FNDC10	96	F2Z333
AARLSCALGVAANCA	ARFGEF3	921	Q5TH69
AEAASPLCVNARCLN	LTBP4	1581	Q8N2S1
LDPFAAVRRESCSCA	DNAAF5	176	Q86Y56
GRFCTINLDDCASRP	DLK2	206	Q6UY11
PCRSAQASVSCALEA	HDAC6	416	Q9UBN7
FACAQLATGAACRLV	HDAC6	576	Q9UBN7
RCVAALSAACPQEAA	CAND2	806	O75155
SAPCLNAATCRDLVN	DNER	511	Q8NFT8
CARLNGRPVCEDSFS	SLC22A7	301	Q9Y694
CAPERLNFPASACAL	NEURL4	1196	Q96JN8
AAPAITCRQDALVCF	PSMF1	11	Q92530
PAACATASQFACRSG	LRP8	256	Q14114
PDAHCQRLASQACRT	F12	166	P00748
ANRTCPICRADASEV	RNF38	496	Q9H0F5
CCSALRPRATQARGS	TMEM176A	36	Q96HP8
SPTCDNFGLLCVARR	TDRD15	286	B5MCY1
LQCFTVRCSAAAARE	HPS3	391	Q969F9
LAAVAASCPQACALS	NTN5	36	Q8WTR8
SACQNSLLCRGSRDP	TENM2	871	Q9NT68
SAAVCGAPCRVLANA	PKHD1	1766	P08F94
NSFSPCSAHDRRCLQ	IGFBP4	126	P22692
SCLCNRFVRPSADEF	ARHGAP35	36	Q9NRY4
PLCARQSFTLAREAC	CHST6	151	Q9GZX3
YCSARTPNRCRAEAL	NEU3	241	Q9UQ49
IPERAFQSACALPSC	TBC1D14	96	Q9P2M4
DLIPAVDRQFACSSC	SHFL	101	Q9NUL5
AAAAVAICQLCDRTP	TRIM67	201	Q6ZTA4
CTSLRAPARNAVCCY	SMRP1	236	Q8NCR6
EASLAPRSARAFCCR	RNF222	176	A6NCQ9
LKANRTCPICRADAS	RNF44	411	Q7L0R7
CAAAAAQAPRRFECG	ZNF574	656	Q6ZN55
RWRTCCAAAAAPSAA	SCAND2P	176	Q9GZW5
DCLDRSFRAQVFSCP	UHRF1	746	Q96T88
CLSRPARCDQATAES	ZZEF1	2546	O43149
LRLRCRAAACNPSDR	SLC30A9	21	Q6PML9
AAAAVAAAASSCRPL	STRN4	6	Q9NRL3
LNVDFCPQAARCCRT	TMEM213	51	A2RRL7