Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	anandamide 8,9 epoxidase activity	CYP2D7 CYP2D6	1.28e-04	4	93	2	GO:0062187
GeneOntologyMolecularFunction	anandamide 11,12 epoxidase activity	CYP2D7 CYP2D6	1.28e-04	4	93	2	GO:0062188
GeneOntologyMolecularFunction	steroid 21-monooxygenase activity	CYP2D7 CYP2D6	1.28e-04	4	93	2	GO:0004509
GeneOntologyMolecularFunction	progesterone 21-hydroxylase activity	CYP2D7 CYP2D6	1.28e-04	4	93	2	GO:0106309
GeneOntologyMolecularFunction	anandamide 14,15 epoxidase activity	CYP2D7 CYP2D6	3.18e-04	6	93	2	GO:0062189
GeneOntologyMolecularFunction	anandamide epoxidase activity	CYP2D7 CYP2D6	3.18e-04	6	93	2	GO:0062186
GeneOntologyMolecularFunction	3'-5' RNA helicase activity	SUPV3L1 AQR	3.18e-04	6	93	2	GO:0034458
GeneOntologyMolecularFunction	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	ST8SIA5 ST8SIA3	3.18e-04	6	93	2	GO:0003828
GeneOntologyMolecularFunction	protein-glutamic acid ligase activity	TTLL4 TTLL7	9.42e-04	10	93	2	GO:0070739
GeneOntologyMolecularFunction	tubulin-glutamic acid ligase activity	TTLL4 TTLL7	9.42e-04	10	93	2	GO:0070740
Domain	Munc13_dom-2	UNC13B BAIAP3	2.22e-04	5	89	2	IPR014772
Domain	Membr_traf_MHD	UNC13B BAIAP3	2.22e-04	5	89	2	PF10540
Domain	MHD2	UNC13B BAIAP3	2.22e-04	5	89	2	PS51259
Domain	Munc13_subgr_dom-2	UNC13B BAIAP3	2.22e-04	5	89	2	IPR019558
Domain	DUF1041	UNC13B BAIAP3	4.64e-04	7	89	2	PF06292
Domain	Munc13_1	UNC13B BAIAP3	4.64e-04	7	89	2	IPR014770
Domain	CAPS_dom	UNC13B BAIAP3	4.64e-04	7	89	2	IPR010439
Domain	MHD1	UNC13B BAIAP3	4.64e-04	7	89	2	PS51258
Domain	DAD_dom	DIAPH3 DAAM1	6.17e-04	8	89	2	IPR014767
Domain	DAD	DIAPH3 DAAM1	6.17e-04	8	89	2	PS51231
Domain	Drf_GBD	DIAPH3 DAAM1	7.91e-04	9	89	2	PF06371
Domain	FH3_dom	DIAPH3 DAAM1	7.91e-04	9	89	2	IPR010472
Domain	GTPase-bd	DIAPH3 DAAM1	7.91e-04	9	89	2	IPR010473
Domain	Drf_FH3	DIAPH3 DAAM1	7.91e-04	9	89	2	PF06367
Domain	Drf_FH3	DIAPH3 DAAM1	7.91e-04	9	89	2	SM01139
Domain	Drf_GBD	DIAPH3 DAAM1	7.91e-04	9	89	2	SM01140
Domain	ARM-type_fold	DNAJC13 UBR4 ATM DIAPH3 DAAM1 IPO4 RALGAPA2	1.18e-03	339	89	7	IPR016024
Domain	GBD/FH3_dom	DIAPH3 DAAM1	1.20e-03	11	89	2	IPR014768
Domain	GBD_FH3	DIAPH3 DAAM1	1.20e-03	11	89	2	PS51232
Domain	NCD3G	TAS1R2 GRM3	1.69e-03	13	89	2	PF07562
Domain	GPCR_3_9-Cys_dom	TAS1R2 GRM3	1.69e-03	13	89	2	IPR011500
Domain	TTL	TTLL4 TTLL7	1.69e-03	13	89	2	PS51221
Domain	TTL/TTLL_fam	TTLL4 TTLL7	1.69e-03	13	89	2	IPR004344
Domain	TTL	TTLL4 TTLL7	1.69e-03	13	89	2	PF03133
Domain	GPCR_3_CS	TAS1R2 GRM3	1.97e-03	14	89	2	IPR017979
Domain	Neurexin-like	CADM1 CNTNAP2	1.97e-03	14	89	2	IPR003585
Domain	4.1m	CADM1 CNTNAP2	1.97e-03	14	89	2	SM00294
Domain	FH2	DIAPH3 DAAM1	2.26e-03	15	89	2	PS51444
Domain	Sialyl_trans	ST8SIA5 ST8SIA3	2.26e-03	15	89	2	IPR012163
Domain	FH2_Formin	DIAPH3 DAAM1	2.26e-03	15	89	2	IPR015425
Domain	FH2	DIAPH3 DAAM1	2.26e-03	15	89	2	PF02181
Domain	FH2	DIAPH3 DAAM1	2.26e-03	15	89	2	SM00498
Domain	Gal_mutarotase_SF_dom	MAN2A2 SI	2.91e-03	17	89	2	IPR011013
Domain	Glyco_trans_29	ST8SIA5 ST8SIA3	4.03e-03	20	89	2	IPR001675
Domain	Glyco_transf_29	ST8SIA5 ST8SIA3	4.03e-03	20	89	2	PF00777
Domain	GPCR_3	TAS1R2 GRM3	4.45e-03	21	89	2	IPR000337
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	PKMYT1 MCMBP DNAJC13 EMC1 MAGED1 C1orf43 UBR4 TMEM131L ANKRD28 ROBO1 PFAS ATM DIAPH3 DAAM1 CRYBG3 IPO4 AQR	5.29e-07	1487	95	17	33957083
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	EMC1 VPS13C DDHD1 TTLL4 CNTNAP2 KDM3B TMEM131L G2E3 DAAM1 FAM149B1	1.94e-06	529	95	10	14621295
Pubmed	Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells.	CYP2D7 CYP2D6	7.38e-06	2	95	2	11032406
Pubmed	Molecular evolution of the CYP2D subfamily in primates: purifying selection on substrate recognition sites without the frequent or long-tract gene conversion.	CYP2D7 CYP2D6	7.38e-06	2	95	2	25808902
Pubmed	Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?	CYP2D7 CYP2D6	7.38e-06	2	95	2	11207030
Pubmed	The Polyadenosine RNA-binding Protein, Zinc Finger Cys3His Protein 14 (ZC3H14), Regulates the Pre-mRNA Processing of a Key ATP Synthase Subunit mRNA.	ATP5MC1 ZC3H14	7.38e-06	2	95	2	27563065
Pubmed	Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.	CYP2D7 CYP2D6	7.38e-06	2	95	2	3123997
Pubmed	The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.	CYP2D7 CYP2D6	7.38e-06	2	95	2	19594327
Pubmed	Coding-noncoding gene expression in intrahepatic cholangiocarcinoma.	CYP2D7 CYP2D6	7.38e-06	2	95	2	26297049
Pubmed	A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.	CYP2D7 CYP2D6	7.38e-06	2	95	2	15051713
Pubmed	Alterations of ATM and CADM1 in chromosomal 11q22.3-23.2 region are associated with the development of invasive cervical carcinoma.	CADM1 ATM	7.38e-06	2	95	2	21643982
Pubmed	Activation-induced cytidine deaminase is a possible regulator of cross-talk between oocytes and granulosa cells through GDF-9 and SCF feedback system.	AICDA GDF9	2.21e-05	3	95	2	33589683
Pubmed	The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.	CYP2D7 CYP2D6	2.21e-05	3	95	2	2574001
Pubmed	Molecular cloning and expression of a fifth type of alpha2,8-sialyltransferase (ST8Sia V). Its substrate specificity is similar to that of SAT-V/III, which synthesize GD1c, GT1a, GQ1b and GT3.	ST8SIA5 ST8SIA3	2.21e-05	3	95	2	8910600
Pubmed	Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation.	DAXX ATM	2.21e-05	3	95	2	23405218
Pubmed	Urinary metabolites to assess in vivo ontogeny of hepatic drug metabolism in early neonatal life.	CYP2D6 UGT1A6	2.21e-05	3	95	2	17609736
Pubmed	Language development and disorders: Possible genes and environment interactions.	CNTNAP2 ROBO1	2.21e-05	3	95	2	30077386
Pubmed	ATM deficiency promotes development of murine B-cell lymphomas that resemble diffuse large B-cell lymphoma in humans.	AICDA ATM	2.21e-05	3	95	2	26400962
Pubmed	Identification of the primary gene defect at the cytochrome P450 CYP2D locus.	CYP2D7 CYP2D6	2.21e-05	3	95	2	1978251
Pubmed	Crosstalk between lysine methylation and phosphorylation of ATG16L1 dictates the apoptosis of hypoxia/reoxygenation-induced cardiomyocytes.	ATG13 TTLL4 ATM	2.93e-05	22	95	3	29634390
Pubmed	DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase.	DAXX ATM	4.41e-05	4	95	2	25659035
Pubmed	Silencing of NRAGE induces autophagy via AMPK/Ulk1/Atg13 signaling pathway in NSCLC cells.	MAGED1 ATG13	4.41e-05	4	95	2	28639909
Pubmed	AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling.	AICDA ATM	4.41e-05	4	95	2	20864035
Pubmed	Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase.	AICDA ANKRD28	4.41e-05	4	95	2	25902538
Pubmed	Gurmarin sensitivity of sweet taste responses is associated with co-expression patterns of T1r2, T1r3, and gustducin.	TLR3 TAS1R2	7.34e-05	5	95	2	18174025
Pubmed	Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response.	AICDA ATM	7.34e-05	5	95	2	26822034
Pubmed	Genetic polymorphisms in CYP1A1, CYP2D6, UGT1A6, UGT1A7, and SULT1A1 genes and correlation with benzene exposure in a Chinese occupational population.	CYP2D6 UGT1A6	7.34e-05	5	95	2	17479406
Pubmed	DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination.	AICDA ATM	7.34e-05	5	95	2	18316419
Pubmed	ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.	AICDA ATM	7.34e-05	5	95	2	17599403
Pubmed	Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis.	UNC13B BAIAP3	7.34e-05	5	95	2	26575293
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	EMC1 MAGED1 SUPV3L1 DDHD1 KDM3B ANKRD28 PFAS CRYBG3 AQR	7.41e-05	650	95	9	38777146
Pubmed	A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination.	AICDA ATM	1.10e-04	6	95	2	24097111
Pubmed	Polymorphism of metabolic genes and susceptibility to occupational chronic manganism.	CYP2D7 CYP2D6	1.10e-04	6	95	2	12171760
Pubmed	Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching.	AICDA ATM	1.54e-04	7	95	2	26308889
Pubmed	Effects of infection of MRSA on the expression and activity of renal cytochrome P450s in mice.	CYP2D7 CYP2D6	1.54e-04	7	95	2	30944282
Pubmed	TTLL1 and TTLL4 polyglutamylases are required for the neurodegenerative phenotypes in pcd mice.	TTLL4 TTLL7	1.54e-04	7	95	2	35404950
Pubmed	Tubulin polyglutamylation stimulates spastin-mediated microtubule severing.	TTLL4 TTLL7	2.05e-04	8	95	2	20530212
Pubmed	Role of the translocation partner in protection against AID-dependent chromosomal translocations.	AICDA ATM	2.05e-04	8	95	2	19966290
Pubmed	Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.	UNC13B BAIAP3	2.05e-04	8	95	2	25609709
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PKMYT1 UNC13B MAN2A2 PPP1R3B TTLL4 UBR4 KDM3B PFAS SLC10A3 RALGAPA2 TEP1	2.17e-04	1105	95	11	35748872
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	MCMBP DNAJC13 EMC1 MAGED1 POLD2 ANKRD28 PFAS IPO4	2.61e-04	606	95	8	36538041
Pubmed	Impaired wound healing with defective expression of chemokines and recruitment of myeloid cells in TLR3-deficient mice.	TLR3 CCL3L1	2.62e-04	9	95	2	21317384
Pubmed	The repertoire of olfactory C family G protein-coupled receptors in zebrafish: candidate chemosensory receptors for amino acids.	TAS1R2 GRM3	3.28e-04	10	95	2	17156446
Pubmed	A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination.	AICDA ATM	3.28e-04	10	95	2	27320916
Pubmed	AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair.	ANKRD28 LRRTM3 GAL3ST2 METTL21EP	3.48e-04	121	95	4	31900314
Pubmed	Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.	AICDA ATM	4.00e-04	11	95	2	16400328
Pubmed	A targeted multienzyme mechanism for selective microtubule polyglutamylation.	TTLL4 TTLL7	5.65e-04	13	95	2	17499049
Pubmed	Expression of multiple formins in adult tissues and during developmental stages of mouse brain.	DIAPH3 DAAM1	6.58e-04	14	95	2	26272686
Pubmed	Quantitative analysis of expression of mouse sialyltransferase genes by competitive PCR.	ST8SIA5 ST8SIA3	7.57e-04	15	95	2	10381338
Pubmed	Genetic variation of genes for xenobiotic-metabolizing enzymes and risk of bronchial asthma: the importance of gene-gene and gene-environment interactions for disease susceptibility.	CYP2D6 UGT1A6	7.57e-04	15	95	2	19575027
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	UNC13B ZNF18 TARS3 PSMG2 CADM1 MAGED1 SUPV3L1 UBR4 ROBO1 CRTAC1 ATM	7.67e-04	1285	95	11	35914814
Pubmed	Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells.	TLR3 CTSD	8.64e-04	16	95	2	25204797
Pubmed	Interaction of Deubiquitinase 2A-DUB/MYSM1 with DNA Repair and Replication Factors.	MCMBP IPO4	8.64e-04	16	95	2	32466590
Pubmed	Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.	PPP1R3B SUPV3L1	8.64e-04	16	95	2	23903356
Pubmed	Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.	EMC1 POLD2 ANKRD28 CTSD	9.03e-04	156	95	4	29961565
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	MAGED1 VPS13C DDHD1 TTLL4 KDM3B TMEM131L ANKRD28 ROBO1	9.10e-04	733	95	8	34672954
Pubmed	Image-based genome-wide siRNA screen identifies selective autophagy factors.	STK32A ATG13 PHYHIP SNRPB2	9.69e-04	159	95	4	22020285
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	MCMBP MAGED1 PFAS DAXX DIAPH3 CRYBG3 IPO4	1.17e-03	588	95	7	38580884
Pubmed	Functional proteomics mapping of a human signaling pathway.	CADM1 PPP1R3B UBR4 KDM3B ANKRD28 DIAPH3 DAAM1	1.20e-03	591	95	7	15231748
Pubmed	A genome-wide association study of the metabolic syndrome in Indian Asian men.	PKMYT1 CRTAC1	1.22e-03	19	95	2	20694148
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	MCMBP DNAJC13 CADM1 MAGED1 SUPV3L1 PDP1 UBR4 KDM3B PFAS IPO4 SNRPB2	1.26e-03	1367	95	11	32687490
Pubmed	The G protein-coupled receptor repertoires of human and mouse.	GPR137 GPR39 FFAR4	1.34e-03	79	95	3	12679517
Pubmed	Nonsyndromic Retinitis Pigmentosa Overview	EMC1 SPP2 CNGA1	1.44e-03	81	95	3	20301590
Pubmed	Biological insights from 108 schizophrenia-associated genetic loci.	MAN2A2 CYP2D6 KDM3B PLCL1 GRM3	1.48e-03	303	95	5	25056061
Pubmed	Dlx transcription factors promote migration through repression of axon and dendrite growth.	CADM1 ROBO1	1.50e-03	21	95	2	17582329
Pubmed	A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.	PKMYT1 STK32A POLD2 AQR	1.53e-03	180	95	4	24104479
Pubmed	A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.	EMC1 VPS13C DAAM1	1.66e-03	85	95	3	23055939
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	MCMBP EMC1 VPS13C SUPV3L1 UBR4 PFAS ATM IPO4 SNRPB2 CTSD AQR	1.76e-03	1425	95	11	30948266
Pubmed	Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer.	CYP2D6 ATM	1.80e-03	23	95	2	16638864
Pubmed	Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women.	ATM CTSD	1.96e-03	24	95	2	19950226
Pubmed	Systematic identification of molecular links between core and candidate genes in breast cancer.	CLCN6 POLD2 TLR3 ATM	2.01e-03	194	95	4	25640309
Pubmed	The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.	DNAJC13 CADM1 EMC1 UBR4 DAXX	2.02e-03	325	95	5	36168628
Pubmed	Regulatory pathway analysis by high-throughput in situ hybridization.	TMEM131L GRM3 DMBX1	2.02e-03	91	95	3	17953485
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ZC3H14 UBR4 ANKRD28 PFAS ATM IPO4 AQR	2.12e-03	653	95	7	22586326
Pubmed	Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements.	HOXD12 CCNE2	2.13e-03	25	95	2	25848055
Pubmed	SSRI treatment modifies the effects of maternal inflammation on in utero physiology and offspring neurobiology.	TLR3 CCL3L1	2.13e-03	25	95	2	36343752
Pubmed	Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.	TTLL4 TTLL7	2.13e-03	25	95	2	29593216
Pubmed	Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate.	MCMBP PFAS	2.13e-03	25	95	2	27621311
Pubmed	Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.	VPS13C CNTNAP2 GRM3 RALGAPA2	2.21e-03	199	95	4	23382691
Pubmed	DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors.	CADM1 CNTNAP2	2.30e-03	26	95	2	34848499
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	MCMBP DNAJC13 CADM1 EMC1 PDP1 ANKRD28 ROBO1 PFAS CRYBG3	2.31e-03	1049	95	9	27880917
Pubmed	Same but different - Molecular comparison of human KTI12 and PSTK.	MAGED1 CRYBG3	2.48e-03	27	95	2	33417976
Pubmed	Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.	UNC13B EMC1 MAGED1 VPS13C	2.63e-03	209	95	4	26389662
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	ANKRD28 ROBO1 PFAS CRYBG3	2.63e-03	209	95	4	36779422
Pubmed	Gene knockouts that cause female infertility: search for novel contraceptive targets.	ATM GDF9	2.66e-03	28	95	2	15970507
Pubmed	Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.	SUPV3L1 PDP1 SI CCL3L1	2.72e-03	211	95	4	7566098
Cytoband	1p36.13	EMC1 UBR4 TAS1R2	2.20e-04	56	95	3	1p36.13
Cytoband	13q33.1	CCDC168 METTL21EP	2.76e-04	12	95	2	13q33.1
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-D_cells_(SST+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRODH2 DNAH12 SI ST8SIA5 ST8SIA3 BAIAP3 FFAR4	1.07e-07	177	95	7	8dbef0005095c01a806d8c7f723dc48a4650efec
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-D_cells_(SST+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRODH2 DNAH12 ZNF534 ST8SIA5 ST8SIA3 BAIAP3	2.01e-06	174	95	6	019eae059bd9eb107dee8f0d0f574ca36c2c26e1
ToppCell	PND28-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PKMYT1 CCNE2 TTLL4 TLR3 PFAS DIAPH3	2.36e-06	179	95	6	9dea57494d59abd6e8abf34e31faf53462ea0fa0
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	UNC13B CADM1 ATP8A1 GPR39 PLCL1	3.20e-05	170	95	5	a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	UNC13B CADM1 ATP8A1 GPR39 DIAPH3	3.47e-05	173	95	5	b799c06a6a5754668e789f70c0c8bc1508568575
ToppCell	Control-Epithelial_cells-AT1\|Control / group, cell type (main and fine annotations)	UNC13B CADM1 GPR39 DIAPH3 TTLL7	3.57e-05	174	95	5	548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRODH2 CRTAC1 ST8SIA3 BAIAP3 FFAR4	3.77e-05	176	95	5	d54543510c804474c5c32e007cd699e75fc5aaba
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	UNC13B CADM1 GPR39 DIAPH3 TTLL7	4.66e-05	184	95	5	57c792e6e2fedba25d3350ffe649fd74750b579d
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	UNC13B CADM1 GPR39 DIAPH3 TTLL7	4.66e-05	184	95	5	29c95b814a0b1ad8734ed68b77df29c08594e5ec
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CRTAC1 ST8SIA5 ST8SIA3 BAIAP3 FFAR4	4.66e-05	184	95	5	1e6f86f9e379cd9f453f6b7185f681b44eb63e09
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	UNC13B CADM1 GPR39 DIAPH3 TTLL7	4.66e-05	184	95	5	d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	UNC13B CADM1 ATP8A1 GPR39 PLCL1	4.78e-05	185	95	5	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	UNC13B CADM1 ATP8A1 GPR39 CRTAC1	4.91e-05	186	95	5	2ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	UNC13B CADM1 GPR39 LRRTM3 DIAPH3	5.03e-05	187	95	5	4ae7465174e0295d2c3b614b321a3b2f514dd22a
ToppCell	Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|World / Lineage, Cell type, age group and donor	UNC13B CADM1 ATP8A1 GPR39 PLCL1	5.03e-05	187	95	5	81cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCell	PCW_10-12-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	STK32A GPR39 ST8SIA3 BAIAP3 FFAR4	5.03e-05	187	95	5	98477ba04a42a8da80a72f41a182429f46283595
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CYP2D6 AICDA CCDC168 CRYBG3 CHST8	5.16e-05	188	95	5	e239bcdbd210a398a5850cb6fbf171d402f45a4f
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRODH2 DNAH12 ST8SIA3 BAIAP3 FFAR4	5.16e-05	188	95	5	b6aad90fa77fbaf80487a55415aa6c245f2d1f7e
ToppCell	droplet-Marrow-nan-3m-Hematologic-erythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCNE2 PHYHIP KEL DIAPH3 DAAM1	5.29e-05	189	95	5	8a38baee58a27c2fa3f4bd131ab9f15723ed9295
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D231\|Adult / Lineage, Cell type, age group and donor	STK32A CADM1 GPR39 DIAPH3 TTLL7	5.29e-05	189	95	5	5a04cb25f8f0447b2cecdb6c3695029281aca26d
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-intermediate_neuroendocrine\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	STK32A ST8SIA3 BAIAP3 FFAR4 TTLL7	5.43e-05	190	95	5	5f1863bce9400b7c932f0e4d0e012ec4e8d7e555
ToppCell	COVID-19-lung-AT2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	UNC13B STK32A CADM1 ATP8A1 GPR39	5.43e-05	190	95	5	27a1a86620fe9b5ee930d388b32352206485e6d0
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	STK32A ST8SIA3 BAIAP3 FFAR4 TTLL7	5.43e-05	190	95	5	b5c6f3248c0c2f648e1578457c6a729ca22bf0da
ToppCell	COVID-19-lung-AT2\|lung / Disease (COVID-19 only), tissue and cell type	UNC13B STK32A CADM1 ATP8A1 GPR39	5.56e-05	191	95	5	276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRODH2 ST8SIA5 ST8SIA3 BAIAP3 FFAR4	5.70e-05	192	95	5	8df4cfe1461819756138ff1180896238dca2787e
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	UNC13B CADM1 ATP8A1 GPR39 PLCL1	5.70e-05	192	95	5	29f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	UNC13B ATP8A1 GPR39 ST8SIA3 BAIAP3	5.99e-05	194	95	5	b30379f8dc41c86c746af9930541fbb4819d8fa0
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CADM1 GPR39 PLCL1 DIAPH3 TTLL7	6.44e-05	197	95	5	8d5097898dd01cedb04cb694cb480c931e08462c
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MAN2A2 ATP8A1 PLCL1 GRM3 TTLL7	6.44e-05	197	95	5	82b8e22317cad6d3786bd70d91107007c0ccd7cd
ToppCell	metastatic_Lymph_Node-B_lymphocytes-GC_B_cells_in_the_DZ\|B_lymphocytes / Location, Cell class and cell subclass	PKMYT1 AICDA CCNE2 DIAPH3 DAAM1	6.60e-05	198	95	5	21c4762ca8591804cf77a23b64470e60d25c5357
Drug	cupreidine	CYP2D7 CYP2D6	1.69e-05	2	94	2	CID000051196
Drug	3-methoxyphenethylamine	CYP2D7 CYP2D6	1.69e-05	2	94	2	CID000074866
Drug	Chelidonine monohydrate (+) [476-32-4]; Down 200; 10.8uM; MCF7; HT_HG-U133A	UNC13B GPR137 CCNE2 ROBO1 ATM FAM149B1 CHST8	1.71e-05	196	94	7	6236_DN
Drug	0173570-0000 [211245-44-2]; Up 200; 1uM; MCF7; HT_HG-U133A	GPR137 EMC1 ATP8A1 PHYHIP ATM TEP1 CHST8	1.77e-05	197	94	7	4715_UP
Drug	Guanadrel sulfate [22195-34-2]; Down 200; 7.6uM; PC3; HT_HG-U133A	GPR137 CADM1 MAN2A2 ATP8A1 CNTNAP2 FAM149B1 BAIAP3	1.89e-05	199	94	7	3698_DN
Disease	solanidine measurement	CYP2D7 CYP2D6	6.00e-05	4	94	2	EFO_0800966
Disease	autosomal recessive intellectual developmental disorder (implicated_via_orthology)	ZC3H14 CNTNAP2	2.78e-04	8	94	2	DOID:0060308 (implicated_via_orthology)
Disease	Prenatal Exposure Delayed Effects	CYP2D6 ATM	6.49e-04	12	94	2	C0033054
Disease	neuronal ceroid lipofuscinosis (implicated_via_orthology)	SPNS3 CTSD	8.91e-04	14	94	2	DOID:14503 (implicated_via_orthology)
Disease	–	TLR3 CCL3L1	1.17e-03	16	94	2	609423
Disease	Susceptibility to HIV infection	TLR3 CCL3L1	1.17e-03	16	94	2	cv:C1836230
Disease	melanoma	PKMYT1 HOXD12 UBR4 ATM GRM3	1.20e-03	248	94	5	C0025202
Disease	disease free survival	CNTNAP2 CCDC168	1.49e-03	18	94	2	EFO_0000409
Disease	Autism Spectrum Disorders	DDHD1 CNTNAP2 LRRTM3	2.56e-03	85	94	3	C1510586
Disease	unipolar depression, response to selective serotonin reuptake inhibitor	CYP2D7 CYP2D6	2.65e-03	24	94	2	EFO_0003761, EFO_0005658
Disease	initial pursuit acceleration	SPP2 CNTNAP2 PFAS	2.73e-03	87	94	3	EFO_0008434
Disease	colon adenocarcinoma (is_marker_for)	PFAS DAXX	2.87e-03	25	94	2	DOID:234 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
DIPRSVQNFRFFASS	ALDH8A1	106	Q9H2A2
FYREFQNPPQLSSLS	ATG13	466	O75143
SSPILSFRYLQANFI	CRYBG3	2556	Q68DQ2
LRQLRDYFPATNSTA	BAIAP3	516	O94812
ASQPVRQFDRYFQSL	GRM3	326	Q14832
NPNLSLRIFTARLYF	AICDA	101	Q9GZX7
RFTNYRFKNLFINPS	CCNE2	86	O96020
PLSSLTFNAINRYTN	ANKRD28	991	O15084
ESRTFRVFLDPNQYQ	AQR	621	O60306
QNLSIFLSSFRVPYE	DIAPH3	721	Q9NSV4
PFLYNRQQRAHSLFL	DAXX	86	Q9UER7
SYSNFPLQVARREFQ	ATP5MC1	41	P05496
PRFLYSQFRRAANSF	ATP8A1	66	Q9Y2Q0
FSNVFNNTTAFPILR	PRODH2	26	Q9UF12
PLLYTVSSQQFRRVF	GPR39	341	O43194
ARYHQNARSRFPQTF	MAGED1	736	Q9Y5V3
LFSFYFRDTPRANRL	GPR137	76	Q96N19
SQPFRLGERSFSRQY	POLD2	36	P49005
SLEQANRTRFPFFSD	FFAR4	16	Q5NUL3
SLRRLQADYASQAPF	SLC10A3	436	P09131
LESQDPRYANRTSLF	HHLA2	81	Q9UM44
FPFYINLSARTSANQ	DNAH12	1916	Q6ZR08
FYQNNTLNTAPDRTR	PIERCE2	96	H3BRN8
FVPQINRNIRFATYT	KDM3B	346	Q7LBC6
DTNFPRSSNNFDYIL	METTL21EP	181	A6NDL7
FRSPNLQLFVFNDST	RALGAPA2	1421	Q2PPJ7
PNSFLNYLVLRVAFS	PDP1	256	Q9P0J1
LLNPNRQTIYFRDFR	CADM1	76	Q9BY67
ITYRLRNDSNFALQT	DAAM1	26	Q9Y4D1
YFSILRNPVFQLESS	GAL3ST2	136	Q9H3Q3
LDAFRNRNFNPSYAI	G2E3	376	Q7L622
AFLSLARFSDTQYQR	ATM	2386	Q13315
SLRKIQFNFPYFRSD	CLCN6	221	P51797
NFRSYLLDLRNTSTP	C1orf43	131	Q9BWL3
YSSSPLSLFRLQEQF	DMBX1	256	Q8NFW5
FQNTPYCFDQLRRRF	CYP2D6	51	P10635
QNIFSFYLSRDPDAQ	CTSD	226	P07339
LNLQSPDSFYFSNLR	HOXD12	16	P35452
DFTPRLQSNTRALYQ	DNAJC13	1221	O75165
NYQRLFDFFNSRPNL	MAN2A2	441	P49641
IFFNNIAYRSSSANR	CRTAC1	361	Q9NQ79
RYNFQAPATNARDSS	CNTNAP2	1016	Q9UHC6
SFNLSEYFRQFLLPQ	GDF9	336	O60383
QYNATAFSSLDRPQL	EMC1	816	Q8N766
SAYFRLQESFFNLPQ	DDHD1	811	Q8NEL9
SQQINYSSFDAPRIR	CCDC168	2941	Q8NDH2
SSTNALRQLQGFPFY	SNRPB2	61	P08579
IGRLFSFLYQSSPDQ	IPO4	1001	Q8TEX9
LNSPRNTTLERQTFY	MCMBP	116	Q9BTE3
QPSADYLDFRNRLQA	PPP1R3B	116	Q86XI6
RPVFSNQFLLENAAY	PCDH11Y	441	Q9BZA8
SSQRRSYAFETQANP	ARHGAP30	1081	Q7Z6I6
RPNTTQSFLLDTQYR	FAM149B1	526	Q96BN6
FSFQLNLSTRPENFL	TARS3	571	A2RTX5
LSQLSPFLENFQSRF	PWWP2A	706	Q96N64
PHQQVFRASRSNNFY	TMC3	606	Q7Z5M5
ANRNANFPLSRDSSY	TMEM131L	1591	A2VDJ0
LSSNRISYFLNNTFR	LRRTM3	116	Q86VH5
SFEREQLLFRQPSSY	KYAT1	291	Q16773
VNSQSLSPYLFRAFR	SPP2	51	Q13103
FLINIESRRPAYNSF	SHOC1	1206	Q5VXU9
YVFSISNNFRSLLPD	ST8SIA3	136	O43173
NASVLLPAFYNTRNT	ST8SIA5	241	O15466
QRLFNPSTNLYFADF	PHYHIP	211	Q92561
VLFTTQNQTPNRFRF	SI	146	P14410
LQFARQYSRNEPLTF	SUPV3L1	591	Q8IYB8
DQRFSQLSDVQNFPY	STK32A	266	Q8WU08
NFFLSLIRAPRNLTF	CHST8	356	Q9H2A9
TRTNYPNIFRISNLV	CNGA1	286	P29973
FSYTSRQIPQNFIAD	CCL3L1	36	P16619
FQNTPYCFDQLRRRF	CYP2D7	51	A0A087X1C5
DRFSARQFPNYSSEL	TRBV5-5	81	A0A597
PNSRIYNRFFTLDTD	PLCL1	126	Q15111
NIEYEYQNPRRSFRS	ZNF700	71	Q9H0M5
NQLRRLPAANFTRYS	TLR3	61	O15455
FRTFLRQQASILSQY	TEP1	1606	Q99973
PDSYLQRFRSLQQSF	SPNS3	436	Q6ZMD2
RPESFFQQSFQRLSR	PKMYT1	101	Q99640
DFYTKRFQELQRNPS	PFAS	201	O15067
LFRQVSTLNSYRNVF	ZNF267	196	Q14586
FRPQDYQRLLEVNSS	THTPA	201	Q9BU02
YRNDFLFSTLLPQEQ	ZNF534	176	Q76KX8
PFFYNRQDNGTLLSL	VPS13C	2931	Q709C8
NSLRIDLSTYRNNFP	UNC13B	866	O14795
NLLFSYQPPQSSSRF	ROBO1	391	Q9Y6N7
NPNYRNSLLFNTSLD	TAS1R2	721	Q8TE23
SYQRNDLQLRSTPFR	PSMG2	126	Q969U7
SPETARQLFRQFRYQ	ZNF18	36	P17022
ERSFLTAPQTEYRNN	UGT1A6	101	P19224
FYLRLSFSRPFQSQN	TGM7	41	Q96PF1
RNNFIRNYLSVSLSE	UBR4	666	Q5T4S7
LRFFEQPRYFNILTT	TTLL4	1036	Q14679
LNSLEETYSPFFRNN	ZC3H14	266	Q6PJT7
NSRYLLPGSTQFFLR	TTLL7	846	Q6ZT98
DLSPQQIFFRSYAQV	KEL	666	P23276