Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

SCRT2 NR2F6 ZNF845 ZNF600 ZNF142 ZNF713 ZFHX4 INSM1 ZNF611 ZSCAN9 ZNF429 ZNF888 ZNF808 PLAG1 ZNF701 ZBTB41 ZNF761 LHX3 ZNF30 ZNF91 BCL6 ZNF468 ZKSCAN4 PRDM5 ZNF354B EP300 NR2F1 ZFP82 ZNF705G ZNF445

8.70e-1814596430GO:0000977
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

SCRT2 NR2F6 ZNF845 ZNF600 ZNF713 ZFHX4 INSM1 ZNF611 ZSCAN9 ZNF429 ZNF888 ZNF808 PLAG1 ZNF701 ZBTB41 ZNF761 LHX3 ZNF30 ZNF91 BCL6 ZNF468 ZKSCAN4 PRDM5 ZNF354B EP300 NR2F1 ZFP82 ZNF445

1.66e-1712446428GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

SCRT2 NR2F6 ZNF845 ZNF600 ZNF713 ZFHX4 INSM1 ZNF611 ZSCAN9 ZNF429 ZNF888 ZNF808 PLAG1 ZNF701 ZBTB41 ZNF761 LHX3 ZNF30 ZNF91 BCL6 ZNF468 ZKSCAN4 PRDM5 ZNF354B EP300 NR2F1 ZFP82 ZNF445

2.91e-1712716428GO:0000987
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

SCRT2 NR2F6 ZNF845 ZNF600 ZNF142 ZNF713 ZFHX4 INSM1 ZNF611 ZSCAN9 ZNF429 ZNF888 ZNF808 PLAG1 ZNF701 ZBTB41 ZNF761 LHX3 ZNF30 ZNF91 BCL6 ZNF468 ZKSCAN4 PRDM5 ZNF354B NR2F1 ZFP82 ZNF705G ZNF445

4.05e-1714126429GO:0000981
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity, RNA polymerase II-specific

SCRT2 NR2F6 INSM1 ZNF91 BCL6 ZKSCAN4 PRDM5 NR2F1

8.09e-06320648GO:0001227
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity

SCRT2 NR2F6 INSM1 ZNF91 BCL6 ZKSCAN4 PRDM5 NR2F1

9.26e-06326648GO:0001217
GeneOntologyMolecularFunctionzinc ion binding

TRIM45 NR2F6 ZFHX4 MARCHF6 SAP30L LHX3 ZNF91 RNF24 EP300 NR2F1 ZMYM5

1.12e-048916411GO:0008270
GeneOntologyMolecularFunctiontransition metal ion binding

TRIM45 NR2F6 ZFHX4 MARCHF6 SAP30L LHX3 ZNF91 RNF24 EP300 NR2F1 ZMYM5

1.29e-0311896411GO:0046914
GeneOntologyBiologicalProcessnegative regulation of transcription by RNA polymerase II

SCRT2 NR2F6 DLL4 INSM1 SAP30L ZNF429 ZNF91 BCL6 PRDM5 ZNF354B EP300 NR2F1 ZMYM5

1.20e-0510536213GO:0000122
MousePhenoabsent thyrotrophs

INSM1 LHX3

5.74e-062342MP:0008339
MousePhenoabnormal neural crest cell morphology

RTEL1 KIT EDN3

5.10e-0530343MP:0009845
MousePhenoabnormal enteric nervous system morphology

KIT GFRA1 EDN3

5.64e-0531343MP:0001044
MousePhenoabnormal multipotent stem cell morphology

RTEL1 KIT EDN3

5.64e-0531343MP:0002400
MousePhenoabnormal neural crest morphology

RTEL1 KIT EDN3

6.21e-0532343MP:0009846
MousePhenoabnormal melanoblast morphology

KIT EDN3

8.56e-056342MP:0009783
MousePhenoabnormal pluripotent precursor cell morphology

RTEL1 KIT EDN3

1.41e-0442343MP:0002399
MousePhenopericardial effusion

RTEL1 DLL4 CDK13 EP300

1.45e-04111344MP:0005312
MousePhenodecreased thyrotroph cell number

INSM1 LHX3

1.59e-048342MP:0008338
MousePhenoabsent somatotrophs

INSM1 LHX3

2.05e-049342MP:0008330
MousePhenoabsent enteric neurons

GFRA1 EDN3

2.05e-049342MP:0001048
DomainZINC_FINGER_C2H2_2

SCRT2 ZNF845 ZNF600 ZNF142 ZNF713 ZFHX4 ZNF804B INSM1 FIZ1 ZNF611 ZSCAN9 ZNF429 ZNF808 PLAG1 ZNF701 ZBTB41 ZNF761 ZNF30 ZNF91 BCL6 ZNF468 ZKSCAN4 PRDM5 ZNF354B ZFP82 ZNF705G ZNF445

3.70e-217756327PS50157
DomainZINC_FINGER_C2H2_1

SCRT2 ZNF845 ZNF600 ZNF142 ZNF713 ZFHX4 ZNF804B INSM1 FIZ1 ZNF611 ZSCAN9 ZNF429 ZNF808 PLAG1 ZNF701 ZBTB41 ZNF761 ZNF30 ZNF91 BCL6 ZNF468 ZKSCAN4 PRDM5 ZNF354B ZFP82 ZNF705G ZNF445

3.96e-217776327PS00028
DomainZnf_C2H2/integrase_DNA-bd

SCRT2 ZNF845 ZNF600 ZNF142 ZNF713 ZFHX4 INSM1 FIZ1 ZNF611 ZSCAN9 ZNF429 ZNF808 PLAG1 ZNF701 ZBTB41 ZNF761 ZNF30 ZNF91 BCL6 ZNF468 ZKSCAN4 PRDM5 ZNF354B ZFP82 ZNF705G ZNF445

4.09e-216946326IPR013087
DomainZnf_C2H2-like

SCRT2 ZNF845 ZNF600 ZNF142 ZNF713 ZFHX4 ZNF804B INSM1 FIZ1 ZNF611 ZSCAN9 ZNF429 ZNF808 PLAG1 ZNF701 ZBTB41 ZNF761 ZNF30 ZNF91 BCL6 ZNF468 ZKSCAN4 PRDM5 ZNF354B ZFP82 ZNF705G ZNF445

7.40e-217966327IPR015880
DomainZnf_C2H2

SCRT2 ZNF845 ZNF600 ZNF142 ZNF713 ZFHX4 ZNF804B INSM1 FIZ1 ZNF611 ZSCAN9 ZNF429 ZNF808 PLAG1 ZNF701 ZBTB41 ZNF761 ZNF30 ZNF91 BCL6 ZNF468 ZKSCAN4 PRDM5 ZNF354B ZFP82 ZNF705G ZNF445

9.90e-218056327IPR007087
DomainZnF_C2H2

SCRT2 ZNF845 ZNF600 ZNF142 ZNF713 ZFHX4 ZNF804B INSM1 FIZ1 ZNF611 ZSCAN9 ZNF429 ZNF808 PLAG1 ZNF701 ZBTB41 ZNF761 ZNF30 ZNF91 BCL6 ZNF468 ZKSCAN4 PRDM5 ZNF354B ZFP82 ZNF705G ZNF445

1.09e-208086327SM00355
Domain-

SCRT2 ZNF845 ZNF600 ZNF142 ZFHX4 INSM1 FIZ1 ZNF611 ZSCAN9 ZNF429 ZNF808 PLAG1 ZNF701 ZBTB41 ZNF761 ZNF30 ZNF91 BCL6 ZNF468 ZKSCAN4 PRDM5 ZNF354B ZFP82 ZNF705G ZNF445

4.46e-2067963253.30.160.60
Domainzf-C2H2

SCRT2 ZNF845 ZNF600 ZNF142 ZNF713 ZFHX4 INSM1 FIZ1 ZNF611 ZSCAN9 ZNF429 ZNF808 ZNF701 ZBTB41 ZNF761 ZNF30 ZNF91 BCL6 ZNF468 ZKSCAN4 PRDM5 ZNF354B ZFP82 ZNF445

1.26e-186936324PF00096
Domainzf-C2H2_6

SCRT2 ZNF845 ZNF600 ZNF611 ZSCAN9 ZNF429 ZNF808 ZNF701 ZBTB41 ZNF761 ZNF30 ZNF91 ZNF468 ZKSCAN4 PRDM5 ZNF354B ZFP82 ZNF445

9.25e-183146318PF13912
DomainKRAB

ZNF845 ZNF713 ZNF611 ZNF429 ZNF808 ZNF701 ZNF761 ZNF30 ZNF91 ZNF468 ZKSCAN4 ZNF354B ZFP82 ZNF705G ZNF445

6.86e-133586315PS50805
DomainKRAB

ZNF845 ZNF713 ZNF611 ZNF429 ZNF808 ZNF701 ZNF761 ZNF30 ZNF91 ZNF468 ZKSCAN4 ZNF354B ZFP82 ZNF705G ZNF445

6.86e-133586315PF01352
DomainKRAB

ZNF845 ZNF713 ZNF611 ZNF429 ZNF808 ZNF701 ZNF761 ZNF30 ZNF91 ZNF468 ZKSCAN4 ZNF354B ZFP82 ZNF705G ZNF445

1.06e-123696315SM00349
DomainKRAB

ZNF845 ZNF713 ZNF611 ZNF429 ZNF808 ZNF701 ZNF761 ZNF30 ZNF91 ZNF468 ZKSCAN4 ZNF354B ZFP82 ZNF705G ZNF445

1.10e-123706315IPR001909
DomainCOUP_TF

NR2F6 NR2F1

1.11e-045632IPR003068
DomainSCAN

ZSCAN9 ZKSCAN4 ZNF445

8.93e-0456633SM00431
DomainSCAN_BOX

ZSCAN9 ZKSCAN4 ZNF445

9.89e-0458633PS50804
DomainSCAN

ZSCAN9 ZKSCAN4 ZNF445

9.89e-0458633PF02023
DomainSCAN_dom

ZSCAN9 ZKSCAN4 ZNF445

9.89e-0458633IPR003309
DomainRetrov_capsid_C

ZSCAN9 ZKSCAN4 ZNF445

1.04e-0359633IPR008916
DomainZnf_RING-CH

MARCHF6 RNF24

1.47e-0317632IPR011016
DomainRINGv

MARCHF6 RNF24

1.47e-0317632SM00744
DomainKAZAL_1

FSTL1 FSTL4

1.65e-0318632PS00282
DomainZnf_C2H2_jaz

ZNF804B PRDM5

2.48e-0322632IPR022755
Domainzf-C2H2_jaz

ZNF804B PRDM5

2.48e-0322632PF12171
DomainKazal_2

FSTL1 FSTL4

6.55e-0336632PF07648
DomainBTB

RCBTB2 ZBTB41 BCL6

9.86e-03131633PF00651
Domainzf-C4

NR2F6 NR2F1

1.05e-0246632PF00105
DomainZnf_hrmn_rcpt

NR2F6 NR2F1

1.05e-0246632IPR001628
DomainNuclear_hrmn_rcpt

NR2F6 NR2F1

1.05e-0246632IPR001723
DomainNUCLEAR_REC_DBD_2

NR2F6 NR2F1

1.05e-0246632PS51030
DomainNUCLEAR_REC_DBD_1

NR2F6 NR2F1

1.05e-0246632PS00031
DomainKAZAL

FSTL1 FSTL4

1.05e-0246632SM00280
DomainZnF_C4

NR2F6 NR2F1

1.05e-0246632SM00399
Domain-

NR2F6 NR2F1

1.10e-02476321.10.565.10
DomainHOLI

NR2F6 NR2F1

1.14e-0248632SM00430
DomainNucl_hrmn_rcpt_lig-bd

NR2F6 NR2F1

1.14e-0248632IPR000536
DomainHormone_recep

NR2F6 NR2F1

1.14e-0248632PF00104
DomainKAZAL_2

FSTL1 FSTL4

1.24e-0250632PS51465
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

NR2F6 ZNF600 ZNF713 CDK13 ZNF804B ZNF611 ZNF429 ZNF701 ZNF761 ZNF30 BCL6 ZNF468 ZKSCAN4 KIT ZNF354B EP300 NR2F1 ZNF705G ZNF445

5.17e-0913874319M734
PathwayREACTOME_GENERIC_TRANSCRIPTION_PATHWAY

NR2F6 ZNF845 CDK13 ZNF804B ZNF429 ZNF808 ZNF91 ZKSCAN4 ZNF354B EP300 NR2F1 ZNF445

2.01e-067684312MM14851
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

NR2F6 ZNF845 CDK13 ZNF804B ZNF429 ZNF808 ZNF91 ZKSCAN4 ZNF354B EP300 NR2F1 ZNF445

3.69e-0510224312MM15436
PathwayBIOCARTA_MELANOCYTE_PATHWAY

KIT EP300

1.89e-047432M22035
PathwayBIOCARTA_MELANOCYTE_PATHWAY

KIT EP300

1.89e-047432MM1555
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF845 ZNF611 ZNF701 ZNF91 ZNF468 ZNF354B ZFP82 ZNF445

1.59e-0918164837372979
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZDHHC6 FIZ1 ZNF429 PLAG1 ZBTB41 ZNF91 ZKSCAN4 PRDM5 PRR3 NR2F1 ZMYM5 ZNF445

2.48e-08808641220412781
Pubmed

Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.

ZNF429 ZNF91 ZKSCAN4 ZFP82 ZNF445

3.22e-08496459630514
Pubmed

Cooperative and indispensable roles of endothelin 3 and KIT signalings in melanocyte development.

KIT EDN3

3.33e-06264215768389
Pubmed

Long-term c-Kit overexpression in beta cells compromises their function in ageing mice.

INSR KIT

3.33e-06264231154478
Pubmed

Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other.

NR2F6 NR2F1

3.33e-0626422905047
Pubmed

Dynamics of GFRα1-positive spermatogonia at the early stages of colonization in the recipient testes of W/Wν male mice.

KIT GFRA1

3.33e-06264222745058
Pubmed

Dual Targeting of Insulin Receptor and KIT in Imatinib-Resistant Gastrointestinal Stromal Tumors.

INSR KIT

3.33e-06264228760855
Pubmed

BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy.

BCL6 EP300

3.33e-06264221041953
Pubmed

A census of human transcription factors: function, expression and evolution.

NR2F6 ZFHX4 INSM1 PLAG1 LHX3 ZNF30 ZNF91 BCL6 PRDM5 NR2F1

5.92e-06908641019274049
Pubmed

Purification of GFRα1+ and GFRα1- Spermatogonial Stem Cells Reveals a Niche-Dependent Mechanism for Fate Determination.

KIT GFRA1

9.99e-06364229337115
Pubmed

Notch-1, c-kit and GFRalpha-1 are developmentally regulated markers for premeiotic germ cells.

KIT GFRA1

9.99e-06364215237212
Pubmed

Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor.

NR2F6 NR2F1

9.99e-06364210644740
Pubmed

Endothelin 3 induces skin pigmentation in a keratin-driven inducible mouse model.

KIT EDN3

9.99e-06364217611578
Pubmed

Reciprocal occupancy of BCL6 and STAT5 on Growth Hormone target genes: contrasting transcriptional outcomes and promoter-specific roles of p300 and HDAC3.

BCL6 EP300

9.99e-06364225088465
Pubmed

Acetylation inactivates the transcriptional repressor BCL6.

BCL6 EP300

9.99e-06364212402037
Pubmed

The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity.

NR2F6 NR2F1

9.99e-06364218701084
Pubmed

An epigenetic switch is crucial for spermatogonia to exit the undifferentiated state toward a Kit-positive identity.

KIT GFRA1

9.99e-06364223903187
Pubmed

Usefulness of translocation-associated immunohistochemical stains in the fine-needle aspiration diagnosis of salivary gland neoplasms.

PLAG1 KIT

9.99e-06364226882287
Pubmed

Sexually dimorphic expression of the novel germ cell antigen TEX101 during mouse gonad development.

KIT GFRA1

9.99e-06364215689535
Pubmed

SCF-KIT signaling induces endothelin-3 synthesis and secretion: Thereby activates and regulates endothelin-B-receptor for generating temporally- and spatially-precise nitric oxide to modulate SCF- and or KIT-expressing cell functions.

KIT EDN3

9.99e-06364228880927
Pubmed

An inhibitor of the acetyltransferases CBP/p300 exerts antineoplastic effects on gastrointestinal stromal tumor cells.

KIT EP300

2.00e-05464227633918
Pubmed

Inactivating mutations of acetyltransferase genes in B-cell lymphoma.

BCL6 EP300

2.00e-05464221390126
Pubmed

Timeline and distribution of melanocyte precursors in the mouse heart.

KIT EDN3

2.00e-05464218444965
Pubmed

Single-cell transcriptomic analysis reveals diversity within mammalian spinal motor neurons.

ZFHX4 LHX3 NR2F1

2.84e-053264336596814
Pubmed

MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression.

LHX3 EP300

3.32e-05564210593900
Pubmed

Notch signal strength controls cell fate in the haemogenic endothelium.

DLL4 KIT

3.32e-05564226465397
Pubmed

IκBα controls dormancy in hematopoietic stem cells via retinoic acid during embryonic development.

DLL4 KIT

4.98e-05664238824124
Pubmed

Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors.

NR2F6 NR2F1

4.98e-0566427947324
Pubmed

TAF4b is required for mouse spermatogonial stem cell development.

KIT GFRA1

4.98e-05664225727968
Pubmed

Histone methyltransferase SETDB1 promotes cells proliferation and migration by interacting withTiam1 in hepatocellular carcinoma.

OSBPL1A ZKSCAN4

6.96e-05764229739365
Pubmed

The heterogeneity of spermatogonia is revealed by their topology and expression of marker proteins including the germ cell-specific proteins Nanos2 and Nanos3.

KIT GFRA1

6.96e-05764219818747
Pubmed

Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate.

DLL4 KIT

6.96e-05764238383534
Pubmed

[Hereditary hypomelanocytoses: the role of PAX3, SOX10, MITF, SNAI2, KIT, EDN3 and EDNRB genes].

KIT EDN3

6.96e-05764224379252
Pubmed

Apolipoprotein B is a new target of the GDNF/RET and ET-3/EDNRB signalling pathways.

GFRA1 EDN3

9.27e-05864222897442
Pubmed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.

ZFHX4 INSR NR2F1 GFRA1 EDN3

1.01e-0425164529031500
Pubmed

Scratch2 modulates neurogenesis and cell migration through antagonism of bHLH proteins in the developing neocortex.

SCRT2 INSM1

1.19e-04964223180754
Pubmed

Genome-wide association with diabetes-related traits in the Framingham Heart Study.

PRDM5 CPVL

1.19e-04964217903298
Pubmed

A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool.

DLL4 LHX3

1.49e-041064217728344
Pubmed

The genetics of pigmentation: from fancy genes to complex traits.

KIT EDN3

1.49e-04106428783939
Pubmed

A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.

ZNF142 CDK13 ZNF91

1.62e-045764316730941
Pubmed

The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition.

DLL4 KIT

1.81e-041164234910918
Pubmed

Retinoid signaling and neurogenin2 function are coupled for the specification of spinal motor neurons through a chromatin modifier CBP.

LHX3 EP300

2.57e-041364219524524
Pubmed

A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells†.

KIT GFRA1

2.57e-041364233394034
Pubmed

Gonocytes-to-spermatogonia transition initiates prior to birth in murine testes and it requires FGF signaling.

KIT GFRA1

2.57e-041364228341395
Pubmed

Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord.

DLL4 LHX3

2.99e-041464217359917
Pubmed

Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: Old and new players.

GFRA1 EDN3

2.99e-041464227370713
Pubmed

Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest.

KIT EDN3

3.45e-041564222186729
Pubmed

Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.

ZNF429 ZNF91

3.45e-041564215885501
Pubmed

Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains.

FIZ1 KIT

3.45e-041564210679268
Pubmed

Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation.

KIT GFRA1

4.45e-041764220572009
Pubmed

Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney Complex Syndrome.

KIT EDN3

4.45e-041764235568059
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

SCRT2 NR2F6 ZNF713 ZSCAN9 BCL6 NR2F1

4.96e-0454464628473536
Pubmed

A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis.

KIT GFRA1

5.59e-041964234686326
Pubmed

Npat-dependent programmed Sertoli cell proliferation is indispensable for testis cord development and germ cell mitotic arrest.

KIT GFRA1

5.59e-041964231084574
Pubmed

The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development.

ZFHX4 LHX3

6.20e-042064235177643
Pubmed

Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.

ZNF429 ZFP82

6.20e-04206427479878
Pubmed

Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.

ZNF429 ZFP82

6.20e-04206422542606
Pubmed

Developmental diversification of cortical inhibitory interneurons.

FSTL1 INSM1 NR2F1

6.43e-049164329513653
Pubmed

Mesenchymal cells are required for functional development of thymic epithelial cells.

DLL4 KIT

6.84e-042164217625108
Pubmed

A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.

NR2F6 NR2F1

7.52e-042264223975195
Pubmed

Reduced endothelin converting enzyme-1 and endothelin-3 mRNA in the developing bowel of male mice may increase expressivity and penetrance of Hirschsprung disease-like distal intestinal aganglionosis.

GFRA1 EDN3

8.96e-042464217131407
Pubmed

Transcriptional control of motor pool formation and motor circuit connectivity by the LIM-HD protein Isl2.

LHX3 GFRA1

9.73e-042564237869988
Pubmed

A G-quadruplex DNA structure resolvase, RHAU, is essential for spermatogonia differentiation.

KIT GFRA1

9.73e-042564225611385
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ZFHX4 FIZ1 SAP30L SIK3 PRDM5 PRR3 EP300 ZFP82

9.88e-04111664831753913
Pubmed

Vsx1 Transiently Defines an Early Intermediate V2 Interneuron Precursor Compartment in the Mouse Developing Spinal Cord.

DLL4 LHX3

1.05e-032664228082864
Pubmed

Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1.

INSM1 OSBPL1A CPVL

1.06e-0310864323383108
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

NR2F6 ZDHHC6 ZSCAN9 BCL6 PRDM5 EP300 ZFP82

1.13e-0387764720211142
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

ZNF142 SIK3 PRDM5 CPVL EP300 ZFP82

1.13e-0363864631182584
Pubmed

Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons.

DLL4 LHX3

1.14e-032764224496616
Pubmed

Proteomic analysis of FOXP proteins reveals interactions between cortical transcription factors associated with neurodevelopmental disorders.

ZFHX4 NR2F1

1.22e-032864229365100
Pubmed

Noggin regulates Bmp4 activity during pituitary induction.

FSTL1 LHX3

1.31e-032964217359964
Pubmed

Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.

ZNF429 ZNF91

1.31e-032964214563677
Pubmed

Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.

BCL6 NR2F1

1.31e-032964220615956
Pubmed

Single-cell transcriptional logic of cell-fate specification and axon guidance in early-born retinal neurons.

FSTL4 KIT

1.40e-033064231399471
Pubmed

Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos.

INSM1 GFRA1

1.40e-033064238636517
Pubmed

Germline deletion of Cdyl causes teratozoospermia and progressive infertility in male mice.

KIT GFRA1

1.40e-033064230850578
Pubmed

Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.

NR2F6 ZFHX4 LHX3 NR2F1

1.42e-0326364420932939
Pubmed

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.

INSR LHX3

1.50e-033164223408906
Pubmed

Selective neuronal lineages derived from Dll4-expressing progenitors/precursors in the retina and spinal cord.

DLL4 LHX3

1.70e-033364225179941
Pubmed

Genome-wide association scan of dental caries in the permanent dentition.

RTEL1 ZNF804B

1.70e-033364223259602
Pubmed

SOX17-positive rete testis epithelium is required for Sertoli valve formation and normal spermiogenesis in the male mouse.

KIT GFRA1

1.80e-033464236543770
Pubmed

A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.

PLAG1 LHX3

1.80e-033464220189936
InteractionTRIM28 interactions

ZNF845 ZNF600 ZNF713 EIF5 ZNF611 ZNF888 ZNF808 ZNF701 ZNF761 ZNF30 ZNF91 ZNF468 ZNF354B DNAJC3 EP300 ZFP82 ZNF445

1.79e-0614746317int:TRIM28
Cytoband19q13.41

ZNF600 ZNF611 ZNF888 ZNF808 ZNF701 ZNF468

1.37e-097864619q13.41
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZNF845 ZNF600 FIZ1 ZNF611 ZNF888 ZNF808 ZNF701 ZNF761 ZNF30 ZNF468 ZFP82

7.29e-0711926411chr19q13
Cytoband19q13.42

ZNF845 FIZ1 ZNF761

7.27e-0412564319q13.42
Cytoband19p13.1

NR2F6 ZNF429

2.07e-034864219p13.1
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

SCRT2 ZNF845 ZNF600 ZNF142 ZNF713 FIZ1 ZNF611 ZSCAN9 ZNF429 ZNF888 ZNF808 PLAG1 ZNF701 ZBTB41 ZNF761 ZNF30 ZNF91 BCL6 ZNF468 ZKSCAN4 PRDM5 ZNF354B ZFP82 ZNF705G ZNF445

1.98e-21718532528
GeneFamilyZinc fingers C2H2-type|SNAG transcriptional repressors

SCRT2 INSM1

3.74e-04105321259
CoexpressionGSE8515_CTRL_VS_IL1_4H_STIM_MAC_UP

TRIM45 CDK13 OSBPL1A PLAG1 ZKSCAN4 PRR3

8.42e-06199636M5759
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_k-means-cluster#3_top-relative-expression-ranked_500

ZNF600 ZFHX4 ZBTB41 BCL6 RNF24 DEPDC1B ZFP82

7.96e-06249627gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_500_k3
CoexpressionAtlasFetal Liver, SC.LTSL.FL, IgM- CD24- CD117+ IL7R- CD150+ CD48- AA4.1+ CD43+, Fetal Liver, avg-3

ZNF600 FSTL1 OSBPL1A PLAG1 PRDM5 KIT DEPDC1B PEAR1

3.06e-05423628GSM791126_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_k-means-cluster#4_top-relative-expression-ranked_500

ZNF600 ZFHX4 ZBTB41 BCL6 RNF24 DEPDC1B

8.31e-05247626gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_500_k4
CoexpressionAtlasStem Cells, SC.LT34F.BM, Lineage- cKit+ Sca-1+ flk2- CD34-, Bone marrow, avg-3

FSTL1 OSBPL1A ZNF808 PLAG1 PRDM5 KIT PEAR1

9.14e-05365627GSM791102_500
CoexpressionAtlasDevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_k-means-cluster#3_top-relative-expression-ranked_1000

FSTL1 INSR EIF5 PLAG1 BCL6 DNAJC3 GFRA1

1.15e-04379627gudmap_developingKidney_e15.5_1000_k3
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_emap-3087_top-relative-expression-ranked_500

ZFHX4 INSM1 BCL6 RNF24 DEPDC1B GFRA1 EDN3

2.30e-04424627gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_emap-3087_k-means-cluster#3_top-relative-expression-ranked_500

ZFHX4 BCL6 RNF24 DEPDC1B

2.35e-04103624gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_500_k3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_top-relative-expression-ranked_500

ZNF600 ZFHX4 ZBTB41 BCL6 RNF24 DEPDC1B ZFP82

2.43e-04428627gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_500
CoexpressionAtlasDevelopingKidney_e15.5_stage III -IV renal corpusc_emap-27945_k-means-cluster#4_top-relative-expression-ranked_500

EIF5 PLAG1 DNAJC3 GFRA1

2.62e-04106624gudmap_developingKidney_e15.5_stage III -IV renal corpusc_500_k4
CoexpressionAtlasratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_500_k-means-cluster#3

SCRT2 ZFHX4 INSM1 SCRG1 EDN3

3.23e-04204625ratio_EB_vs_SC_500_K3
CoexpressionAtlasdev gonad_e12.5_F_GermCellOvary_Oct_k-means-cluster#3_top-relative-expression-ranked_200

ZNF845 ZNF600 KIT

3.29e-0446623gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_k3_200
CoexpressionAtlasAravindRamakr_StemCell-LF_top-relative-expression-ranked_2500_k-means-cluster#4

ZNF713 ZNF429 ZNF808 ZKSCAN4 CPVL PGBD2 ZNF445

3.48e-04454627Arv_SC-LF_2500_K4
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZFHX4 ZNF804B KIT GFRA1 EDN3

4.00e-06165645b1bbf5acdfc52bd8c7c7eb356d73b812eb6b908c
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-stromal_related|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZFHX4 ZNF804B KIT GFRA1 EDN3

4.00e-0616564528f8297ec7b781149cc7ac2f5e441771083b8ee3
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ZFHX4 BCL6 NR2F1 GFRA1 ZNF705G

5.78e-06178645d4ecb84e9b1f4ec49c519321156aa10f9bd34cce
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZFHX4 OSBPL1A KIT GFRA1 EDN3

6.62e-06183645262387ee8d43b96e5f1a77c75124459a506a6172
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZFHX4 OSBPL1A KIT GFRA1 EDN3

6.62e-06183645c85a707acbcb582912e8ac080a36d05f91cfd7a2
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-stromal_related|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZFHX4 OSBPL1A KIT GFRA1 EDN3

8.35e-061926458ad6678df89175c5a4a835c8566f1552df3c996e
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZFHX4 OSBPL1A KIT GFRA1 EDN3

8.35e-061926452f5378ea0b2fb2f672a36585d375f675983363a1
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FSTL1 ZFHX4 BCL6 NR2F1 GFRA1

8.56e-0619364509a9ab029f01234459a88e3e994fe90ef4cbb8c6
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZFHX4 OSBPL1A KIT GFRA1 EDN3

8.56e-06193645f27e2be497745098b5269aa799dd3d5f62d78ba7
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FSTL1 ZFHX4 BCL6 NR2F1 GFRA1

8.56e-06193645c8c21eee8c6c086dc2faf416669cd4a002870fbe
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FSTL1 ZFHX4 BCL6 NR2F1 GFRA1

8.56e-061936455b602b1702283184bd3943c2a6f2290b7c37e407
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZFHX4 OSBPL1A KIT GFRA1 EDN3

8.56e-061936454ccf984baebbb13ae916727137ce593fda7514a2
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FSTL1 DLL4 INSR KIT EDN3

8.78e-06194645ea5e1bc8d9e27cabfe1fb833ca47ec0893593b12
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FSTL1 DLL4 INSR KIT EDN3

8.78e-06194645cceb7c88492bb6cd531e1c2651638da1ddf30931
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FSTL1 ZFHX4 BCL6 NR2F1 GFRA1

9.23e-061966453a6c942e2907aa07b5e12dbf9019d18f7bfca507
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FSTL1 ZFHX4 BCL6 NR2F1 GFRA1

9.23e-06196645bba88e91cd3e3a6f5a9b443e3a4da33c5b455e70
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FSTL1 ZFHX4 BCL6 NR2F1 GFRA1

9.46e-0619764509946ee8dfb15a2a32da06e5b331f3277ee934f4
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FSTL1 DLL4 INSR EDN3 PEAR1

9.69e-0619864572e8b9cccb7b0a2ea9d415218fff4fa2f09728f4
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FSTL1 DLL4 INSR EDN3 PEAR1

9.69e-06198645e1fa02184ce93c4f8aa5cf04b70949cd4c425ff0
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FSTL1 DLL4 INSR EDN3 PEAR1

9.93e-061996459c40b3ee39860e9d8edafd007daec11abdd95435
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FSTL1 DLL4 INSR EDN3 PEAR1

9.93e-0619964572b34bce8157abe389e95cd3ed8ba578dce0cbf6
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FSTL1 DLL4 INSR ALKAL2 PEAR1

9.93e-061996451295f34a350bf48987e2fad411aaac3630efd3f1
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate|5w / Sample Type, Dataset, Time_group, and Cell type.

ZFHX4 INSM1 INSR RNF24 NR2F1

1.02e-05200645c92e4fc0442404481fcac623d691dae6215b852d
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FSTL1 SCRG1 ALKAL2 NR2F1 GFRA1

1.02e-052006455c6520dc4c4693827f6680651785680b5883afb8
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Vipr2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ZNF804B ALKAL2 KIT GFRA1

4.94e-0514064472c272f44e5600b3037c1dbf9d3a4669a35588d8
ToppCell367C-Lymphocytic-NK_cells-NK_cell_E|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ZNF713 FSTL1 PLAG1 ZNF761

7.70e-05157644432b8719a8afd289cf48068e12c26a349d753fcc
ToppCellCOVID-CD4-CD4_Treg|COVID / Condition, Cell_class and T cell subcluster

ZNF701 ZNF30 EP300 ZMYM5

8.09e-05159644037cd97c41eb2f91fd3f69bbb3ffdfd6c0158410
ToppCell367C-Lymphocytic-NK_cells-NK_cell_E|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

ZNF713 FSTL1 PLAG1 ZNF761

9.78e-05167644b5d15773be32cd277125fd3b4056a8fefaefa5ec
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF808 PKD1L3 CPVL ZNF354B

9.78e-05167644881f64db8dea3faa7588bf04d87c20924a4e5952
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-like-AT2_Progenitor|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF142 ZNF611 CPVL ZFP82

1.00e-041686449e7b4b9b977e90e083f5164013e79df8bc2d492e
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-stromal_related|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZFHX4 KIT GFRA1 EDN3

1.00e-04168644e40a3f85be7e9bb23bfbc1f9cb5e5fc54bb43863
ToppCellBAL-Control-cDC_6|Control / Compartment, Disease Groups and Clusters

EIF5 PLAG1 ZNF91 KIT

1.00e-0416864465ec473cff748b334c0a66e33bc34a8465fe7631
ToppCell368C-Lymphocytic-NK_cells-NK_cell_C|368C / Donor, Lineage, Cell class and subclass (all cells)

RTEL1 RCBTB2 ZNF30 KIT

1.00e-041686440372c06b70f0ba95bf8cd1363ca7c5f31207f094
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZFHX4 KIT GFRA1 EDN3

1.00e-04168644b1d6c35a5ae69c8638afd68c2be5bc9ce6fd2659
ToppCellfacs-Lung-Endomucin-3m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FIZ1 NR2F1 ZFP82 EDN3

1.02e-041696442d23b4cee060f8adddc430c1c10d4e25205b4af6
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Hematologic-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NR2F6 ZFHX4 PRR3 GFRA1

1.02e-0416964415a9183c838cc6384d7f5dfeae3d30602964c9b3
ToppCellfacs-Lung-Endomucin-3m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FIZ1 NR2F1 ZFP82 EDN3

1.02e-04169644ecaf08e8e0b54d1c97a02bc1f65409fd43d68227
ToppCellfacs-Lung-Endomucin-3m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FIZ1 NR2F1 ZFP82 EDN3

1.02e-04169644ad6af6609acf158cb79e45ee7ca9af332be3c40c
ToppCellEndothelial-B-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

ZFHX4 DLL4 NR2F1 PEAR1

1.07e-0417164407ff7059071da83da1d8f266a586573920d75b58
ToppCellsevere_influenza-Neutrophil|severe_influenza / disease group, cell group and cell class (v2)

ZNF429 BCL6 PRDM5 KIT

1.12e-04173644615e266419b9f06e964eff73cb466f05451ba0dd
ToppCellBronchial_Biopsy-Epithelial-Ionocytes|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

DLL4 ALKAL2 KIT GFRA1

1.17e-0417564413b8f7dc38c90b74d4a20a84a8705d8e2ec244f6
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ZNF142 ZFHX4 SCRG1 GFRA1

1.17e-04175644085cceb1fc2c4ae2f27e85cea5702defecc2cf44
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-early_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIM45 DLL4 ZBTB41 GFRA1

1.20e-041766447292e014b8f697f0c2e9f47c48333de95cb44a69
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-early_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIM45 DLL4 ZBTB41 GFRA1

1.20e-0417664488ca2f83d8301633232735f39b0683efe49d0b86
ToppCell368C-Lymphocytic-NK_cells-NK_cell_C|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

RTEL1 RCBTB2 ZNF30 KIT

1.25e-0417864450bb1f2c6a8d050ff2af217fd76c3b1b7b4a4a69
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FSTL1 ZFHX4 NR2F1 GFRA1

1.25e-0417864478a0c6340001a77f5b2d890b6263f574af2e72da
ToppCellwk_08-11-Mesenchymal-Fibroblast-Mesenchymal_1|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ZFHX4 KIT GFRA1 EDN3

1.33e-041816447e3bcfa2ba5b98a7df5854aa6e7a31e9a71faa8a
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FSTL1 NR2F1 GFRA1 PEAR1

1.33e-04181644c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FSTL1 NR2F1 GFRA1 PEAR1

1.33e-04181644c62b0a2422377ffadaab63edd538e87a06fa5017
ToppCellPCW_07-8.5-Neuronal-Neuronal_SCP-neuro_pre_proliferating_SCP_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ZFHX4 INSM1 SCRG1 GFRA1

1.36e-04182644bfb725fff3d20066d8ac0a6ba2f88498fcbd876e
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF713 FSTL1 SCRG1 GFRA1

1.42e-0418464454e5b63f55b8d6eccad53d389ea9c78f991e1414
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes-Fibromyocytes_L.2.3.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF713 FSTL1 SCRG1 GFRA1

1.42e-041846447b5678718719020b52e7c2a7bd9797987defd7ff
ToppCell343B-Fibroblasts-Fibroblast-E-|343B / Donor, Lineage, Cell class and subclass (all cells)

OSBPL1A SCRG1 ALKAL2 PEAR1

1.48e-041866441bac7825c2fe3e6cdff65026b09b9ccaa40fa27f
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FSTL1 DLL4 INSR KIT

1.48e-04186644a906020a8df6fcca474b278f746c553b177a56b4
ToppCell343B-Fibroblasts-Fibroblast-E|343B / Donor, Lineage, Cell class and subclass (all cells)

OSBPL1A SCRG1 ALKAL2 PEAR1

1.48e-0418664459db239f1864a5d4f1570c93219dbd7ac5b6db35
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FSTL1 PLAG1 PRDM5 EDN3

1.48e-04186644827f2f2ddde315d1e5970dd56f906c555ec699af
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FSTL1 ZFHX4 BCL6 GFRA1

1.48e-041866447582b5154d8e5a4434817b5ab77a10b789ea2288
ToppCellCOVID-19-kidney-Fibroblast-1|COVID-19 / Disease (COVID-19 only), tissue and cell type

ZFHX4 INSR NR2F1 GFRA1

1.51e-0418764476bfe8c42430a230a8bdf299575c444fb7780f24
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor-cycling_neuroblast|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

INSM1 SCRG1 DEPDC1B GFRA1

1.54e-0418864433afe31b1093d317dc38c324197c6e91bf6c39d3
ToppCellmild-Others|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

FSTL1 BCL6 RNF24 PEAR1

1.61e-04190644782dc1b612ac1faad7cc2781bfda92a079830d38
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FSTL1 ZFHX4 GFRA1 EDN3

1.64e-041916447d1595e616f6f111fc2f5bc1b179c5d67d624cc9
ToppCellmild-Others-Megakaryocytes|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

FSTL1 BCL6 RNF24 PEAR1

1.64e-041916440b36223bd7f5758cc37194da6cc252f613bc3c97
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FSTL1 ZFHX4 NR2F1 GFRA1

1.67e-041926445105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FSTL1 ZFHX4 NR2F1 GFRA1

1.74e-04194644e03ba6caed59fa64d4d9b042593469d4a6a3dc10
ToppCell10x3'2.3-week_17-19-Mesenchymal_osteo-stroma-osteoblast_precursor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FSTL1 ZFHX4 GFRA1 EDN3

1.77e-04195644ec12cfb2fce44cc2de4e198ef5af075e626f0329
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZFHX4 OSBPL1A KIT EDN3

1.77e-0419564419347b7e8d3ea67e0fddd948078abcab9d364a2d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FSTL1 ZFHX4 NR2F1 GFRA1

1.77e-04195644cad6563cc51d212554152c727fc2c249c6a07e4d
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-stromal_related|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZFHX4 OSBPL1A KIT EDN3

1.77e-0419564455b4030f078173b0136990fae87b6eaf44c58f33
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FSTL1 ZFHX4 NR2F1 GFRA1

1.77e-04195644783bfa8110161cbd6def50ce849cae676c39c458
ToppCellTracheal-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DLL4 PKD1L3 NR2F1 PEAR1

1.81e-0419664409a7edf4a7defb7fe70d9777dd9500ee8421ff31
ToppCellTracheal-NucSeq-Endothelial-Endothelia_lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DLL4 PKD1L3 NR2F1 PEAR1

1.81e-04196644e50d2c66d5c5cd25fdfecdcc4c8506a1d0a85755
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-IPC/newborn-38|World / Primary Cells by Cluster

SCRT2 ZFHX4 INSM1 NR2F1

1.81e-0419664438da0751941adca650fe9b383d9f343153978eb5
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-IPC/newborn|World / Primary Cells by Cluster

SCRT2 ZFHX4 INSM1 NR2F1

1.81e-04196644721650a08d260faf530dbd52d4e9275d27f3bac2
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FSTL1 INSR EDN3 PEAR1

1.81e-04196644889c9fed857f64664ca1f47fcec9fecb15ed103c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FSTL1 INSR EDN3 PEAR1

1.84e-04197644e567f91fa398fd306d025dcfe89bd50a60216537
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZFHX4 OSBPL1A GFRA1 EDN3

1.84e-041976442a90422ba400b951517603a916f34221056d0f3d
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ZNF713 FSTL4 ZSCAN9 KIT

1.84e-04197644fd76cc5e12c7e7943a48f739e4f0626ff7211f51
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FSTL1 ZFHX4 NR2F1 EDN3

1.84e-04197644c7b33d64e5cba3a8fc6f2d6aa85ebc83893195de
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-immature_mesenchymal_cell|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FSTL1 ZFHX4 NR2F1 EDN3

1.84e-04197644fc718a254bda4df2d62975d04393492fb75ab305
ToppCell3'-Adult-LymphNode-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FSTL1 ZFHX4 BCL6 ALKAL2

1.88e-04198644abac765c4f6864bdb1700bc546c3b9771edc25c3
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FSTL1 DLL4 INSR EDN3

1.88e-04198644218f33e068eb126458ec33176de3cfa6fc06ddf0
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-IPC_like-IPCs|1_mon / Sample Type, Dataset, Time_group, and Cell type.

DLL4 INSM1 RNF24 CPVL

1.88e-04198644b3488e916fff9a4ff62eb897d3783c93296dbd65
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FSTL1 ZFHX4 BCL6 NR2F1

1.88e-0419864479576525a10ed3e3a9d1608077cd16ecda23376f
ToppCell3'-GW_trimst-1-LargeIntestine|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FSTL1 ZFHX4 NR2F1 EDN3

1.88e-04198644ea6621a148a96c8ffa1a93a35c9e288545d2637a
ToppCell3'-Adult-LymphNode-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FSTL1 ZFHX4 BCL6 ALKAL2

1.88e-04198644ff57addcbdd53e5d2d0c80ec76b5eab3b3a67ca2
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-IPC_like|1_mon / Sample Type, Dataset, Time_group, and Cell type.

DLL4 INSM1 RNF24 CPVL

1.88e-041986446d99901d4df24eb3c5cca80afd9a81eb7ee8fcf1
ToppCell3'-Adult-LymphNode-Mesenchymal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FSTL1 ZFHX4 BCL6 ALKAL2

1.88e-04198644698166b4ca173176ed563af6a1efc8c7d0a18e0b
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DLL4 INSR KIT PEAR1

1.92e-04199644d95d78b2ebc9a20532466e4d4be579b4faf6776f
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DLL4 INSR KIT PEAR1

1.92e-04199644cdcfca94baba66e213cc3ffb0cfb4c75d6ab44ec
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

INSR OSBPL1A KIT DNAJC3

1.92e-04199644fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FSTL1 DLL4 INSR PEAR1

1.92e-04199644463ba77dc4c85eebb343f29a42c7ac889b0497c9
ToppCellBronchus_Control_(B.)-Stromal-TX|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

FSTL1 ZFHX4 NR2F1 GFRA1

1.95e-0420064469b41f5fb370aa8840a9ad7919d03ef1e57d1b5b
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR|Neuronal / cells hierarchy compared to all cells using T-Statistic

ZFHX4 SCRG1 BCL6 KIT

1.95e-04200644862db57d043bdf3cb059fbfc8b29bc1eafdf64ec
ToppCellSigmoid-T_cell-cycling_gd_T|T_cell / Region, Cell class and subclass

ZKSCAN4 PKD1L3 PRR3 DEPDC1B

1.95e-042006444e489ecf472857357d45e9f6c7a812aa48b72ebf
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR--L1|Neuronal / cells hierarchy compared to all cells using T-Statistic

ZFHX4 SCRG1 BCL6 KIT

1.95e-04200644a91345f268f13170c27309333603eb82400c9947
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Interneuron|10w / Sample Type, Dataset, Time_group, and Cell type.

SCRT2 ZFHX4 ZNF91 NR2F1

1.95e-04200644f5c63ef52bd7a898cf009b8bf9b2f7f4890d1c9b
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_1-AF2|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FSTL1 ZFHX4 NR2F1 GFRA1

1.95e-0420064444317fbf4d1480a37b50ab2777bf1a3e4fc0c05f
ToppCellSigmoid-(1)_T_cell-(18)_cycling_gd_T|Sigmoid / shred on region, Cell_type, and subtype

ZKSCAN4 PKD1L3 PRR3 DEPDC1B

1.95e-042006446e367abd1a4b87e20eb9095b8337723163e8bbae
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR-|Neuronal / cells hierarchy compared to all cells using T-Statistic

ZFHX4 SCRG1 BCL6 KIT

1.95e-04200644d416a7be1a4e6232fb58a9687774da24821f1fdd
ToppCellcellseq2-Mesenchymal-Fibroblastic|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FSTL1 ZFHX4 NR2F1 GFRA1

1.95e-042006441c10597edd532bf172ca09870a937d35e2585081
DrugMethylene Chloride

NR2F6 ZFHX4 ZBTB41 BCL6 ZNF354B ZNF445

5.42e-06163626ctd:D008752
DiseaseSmall cell carcinoma of lung

INSM1 KIT EP300

2.13e-0454633C0149925
DiseaseHirschsprung's disease (implicated_via_orthology)

GFRA1 EDN3

2.92e-0412632DOID:10487 (implicated_via_orthology)
DiseaseT-Cell Lymphoma

BCL6 EP300

5.28e-0416632C0079772
Diseasediabetic retinopathy (implicated_via_orthology)

INSR EP300

5.28e-0416632DOID:8947 (implicated_via_orthology)
DiseaseLung diseases

INSR KIT EDN3

6.30e-0478633C0024115
Diseasepulmonary embolism

ZNF808 ZNF701

1.30e-0325632EFO_0003827
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

NR2F6 INSR NR2F1

1.49e-03105633DOID:9352 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
ICKQLIALCCYHAKH

EP300

1781

Q09472
RLCKKRNDHFGHYVC

DLL4

186

Q9NR61
RKHRCRFKSYEHCFT

DEPDC1B

31

Q8WUY9
LDQDHKRCFAHYKQV

DNAJC3

251

Q13217
DYCHKKNFLHRDIKC

CDK13

826

Q14004
CVKERVCRYLLHHYL

ATG2A

11

Q2TAZ0
YAHKVLLKIRCEHFR

RCBTB2

406

O95199
DQHHRNQCQYCRLKK

NR2F6

101

P10588
DQHHRNQCQYCRLKK

NR2F1

131

P10589
ERHKKYRCELCNKAF

PRDM5

456

Q9NQX1
KRAYHRLCLHCSVDQ

KIT

176

P10721
YFQKQCHECIEHIRK

CPVL

266

Q9H3G5
KTDHRQRLQCCHGFY

PEAR1

81

Q5VY43
HSRKEYCELCKHRFA

MARCHF6

46

O60337
YHLHCFACVVCKRQL

LHX3

111

Q9UBR4
KLCQYHFAEKQFCRH

FBXO25

271

Q8TCJ0
HKCKNSRRQGCHQYV

INSR

291

P06213
HCAAYRAHKQCALKL

OSBPL1A

181

Q9BXW6
RDYCAHHLIRLLKCK

NDUFB7

56

P17568
EQIKKYRRHFLRFCH

EIF5

291

P55010
YRRHFLRFCHNNKKA

EIF5

296

P55010
VCNRRKCHKALRQFF

GFRA1

186

P56159
HHRSRRCTCFTYKDK

EDN3

91

P14138
RFYENHCKLHRAACL

FSTL4

106

Q6MZW2
KTYLNHCELHRDACL

FSTL1

71

Q12841
KPYHCEKCNLHFRHK

BCL6

656

P41182
ECGKFFRHECYLKRH

FIZ1

446

Q96SL8
EVKRALCCTLHLYQH

OR6A2

301

O95222
LYECHHCAKKFRRQA

INSM1

366

Q01101
HCAKKFRRQAYLRKH

INSM1

371

Q01101
HLCRKKVASRSCHFY

RTEL1

161

Q9NZ71
HFCCQAHRRQKKTTY

TRIM45

156

Q9H8W5
THSAFKHYRCRQCDK

SCRT2

261

Q9NQ03
CRHFAKKGHCRYEDL

PRR3

161

P79522
HFCCYLHRVLQRLKS

PKD1L3

1071

Q7Z443
VYFCHCRNIVHRDLK

SIK3

176

Q9Y2K2
LFCCYLIRLRHQAHK

RNF24

41

Q9Y225
LSCYRKILKDHNCHN

SCRG1

26

O75711
CSKHFHRLYHNTRDC

ALKAL2

111

Q6UX46
KCQKGVHAKCFREYH

PGBD2

576

Q6P3X8
VFNQKRYLACHRRCH

ZNF845

251

Q96IR2
KEKKHQCEHCDRRFY

PLAG1

181

Q6DJT9
AYKAPRSHHCRKCNR

ZDHHC6

106

Q9H6R6
YECKECGKAFRVHVH

ZNF30

456

P17039
DRHVYKYRCNHCSLA

ZFHX4

1346

Q86UP3
CHHRLHTGEKAYKCN

ZNF761

511

Q86XN6
ERHKRKCLKHNCFYL

ZNF804B

751

A4D1E1
KSVRHLYICDFHKNF

SAP30L

66

Q9HAJ7
FCSRHFCYKKSLENH

ZBTB41

211

Q5SVQ8
KLFNHKQYLACHRRC

ZNF808

266

Q8N4W9
KQYLACHRRCHTGEK

ZNF808

271

Q8N4W9
LCEKAYTNCFHLRRH

ZNF705G

176

A8MUZ8
VCDKAFKCYSHLAQH

ZNF888

666

P0CJ79
FCIRLHKTQHKCVYI

ZNF91

191

Q05481
YECKECKKAFRQHSH

ZFP82

506

Q8N141
QKNAIGSRRHYCHEC

ZKSCAN4

311

Q969J2
VTHKLCSNHCFNKYR

ZMYM5

356

Q9UJ78
QCRKSFHCKSYVLEH

ZNF445

601

P59923
EKHYRCEECGKAFNH

ZNF429

226

Q86V71
KLFNHEQYLACHDRC

ZNF611

266

Q8N823
HRKIHTREKLCEYKC

ZNF713

416

Q8N859
RGIHNIQKRYHCKEC

ZSCAN9

301

O15535
KDFHQKRYLACHRCH

ZNF701

316

Q9NV72
KHTRLREFHCALCDY

ZNF142

566

P52746
CKHLRTHTVEKCYRC

ZNF354B

286

Q96LW1
GKLFNHKQYLTCHCR

ZNF600

196

Q6ZNG1
VFNQKRYLACHRRCH

ZNF468

251

Q5VIY5