Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionPyrin domain binding

NLRP2 PYCARD

1.14e-0431242GO:0032090
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

PKD1L2 PKDREJ RYR1 SLC30A6 NALCN SLC22A1 SCN5A TRPM8 GRIN3A SLC4A4 SLC4A9

1.54e-0446512411GO:0046873
GeneOntologyMolecularFunctionubiquitin-like ligase-substrate adaptor activity

DCAF1 PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

1.59e-04821245GO:1990756
GeneOntologyMolecularFunctionenzyme-substrate adaptor activity

DCAF1 PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

3.16e-04951245GO:0140767
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

3.78e-04551244GO:0042974
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

PKD1L2 PKDREJ RYR1 SLC30A6 NALCN SLC15A2 SLC22A1 SCN5A TMC8 TMEM150C TRPM8 GRIN3A SLC4A4 SLC4A9

4.12e-0479312414GO:0015075
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

PKD1L2 PKDREJ RYR1 SLC30A6 NALCN SLC15A2 SLC22A1 SCN5A TRPM8 GRIN3A SLC4A4 SLC4A9

5.36e-0462712412GO:0022890
GeneOntologyMolecularFunctionsodium:bicarbonate symporter activity

SLC4A4 SLC4A9

5.65e-0461242GO:0008510
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

PKD1L2 PKDREJ RYR1 SLC30A6 NALCN SLC15A2 SLC22A1 SCN5A TRPM8 GRIN3A SLC4A4 SLC4A9

8.85e-0466412412GO:0008324
GeneOntologyBiologicalProcessbrainstem development

NLGN4Y NLGN4X SCN5A

1.16e-0581243GO:0003360
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

PRAMEF5 PRAMEF4 ARIH1 PRAMEF11 PRAMEF6

9.56e-06471275GO:0031462
GeneOntologyCellularComponentcullin-RING ubiquitin ligase complex

DCAF1 CUL4A PRAMEF5 FBXL17 PRAMEF4 ARIH1 PRAMEF11 PRAMEF6

4.68e-052121278GO:0031461
GeneOntologyCellularComponentubiquitin ligase complex

DCAF1 CUL4A PRAMEF5 FBXL17 PRAMEF4 MEGF8 ABTB1 ARIH1 PRAMEF11 PRAMEF6

5.90e-0535212710GO:0000151
GeneOntologyCellularComponentsymmetric, GABA-ergic, inhibitory synapse

NLGN4Y NLGN4X

2.18e-0441272GO:0098983
GeneOntologyCellularComponentasymmetric, glutamatergic, excitatory synapse

NLGN4Y NLGN4X PLXNC1

4.04e-04241273GO:0098985
DomainARM-type_fold

DCAF1 RALGAPA1 CLASP1 NEK10 UBR4 RALGAPA2 RANBP17 THADA ELMO2 NBEAL2 WDFY3 TARBP1

2.72e-0633912412IPR016024
DomainTransform_prot_C-ets

ETS1 ETS2

4.37e-0521242IPR016311
DomainNLGN4

NLGN4Y NLGN4X

4.37e-0521242IPR030025
Domain-

PRAMEF5 FBXL17 LRRK1 PRAMEF4 NLRP2 OMG LRIG3 LRRC53 LRRC37B PRAMEF6

5.66e-05321124103.80.10.10
DomainL_dom-like

PRAMEF5 FBXL17 LRRK1 PRAMEF4 NLRP2 OMG LRIG3 LRRC53 LRRC37B PRAMEF6

6.77e-0532812410IPR032675
DomainARM-like

DCAF1 CLASP1 NEK10 RANBP17 ELMO2 NBEAL2 WDFY3 TARBP1 HOMEZ

8.05e-052701249IPR011989
DomainLH2

PKD1L2 PKDREJ ALOXE3

2.17e-04181243SM00308
DomainPRAME_family

PRAMEF5 PRAMEF4 PRAMEF6

2.56e-04191243IPR026271
DomainREJ

PKD1L2 PKDREJ

2.60e-0441242PS51111
DomainREJ_dom

PKD1L2 PKDREJ

2.60e-0441242IPR014010
Domain-

PKD1L2 PKDREJ ALOXE3

3.48e-042112432.60.60.20
DomainPLAT

PKD1L2 PKDREJ ALOXE3

3.48e-04211243PF01477
DomainPLAT/LH2_dom

PKD1L2 PKDREJ ALOXE3

3.48e-04211243IPR001024
DomainPLAT

PKD1L2 PKDREJ ALOXE3

3.48e-04211243PS50095
DomainNa/HCO3_transpt

SLC4A4 SLC4A9

4.32e-0451242IPR003024
DomainNlgn

NLGN4Y NLGN4X

4.32e-0451242IPR000460
DomainPKD_2

PKD1L2 PKDREJ

4.32e-0451242IPR003915
DomainDUF4704

NBEAL2 WDFY3

4.32e-0451242IPR031570
DomainDUF4704

NBEAL2 WDFY3

4.32e-0451242PF15787
DomainPH_BEACH

NBEAL2 WDFY3

6.45e-0461242PF14844
DomainPKD/REJ-like

PKD1L2 PKDREJ

6.45e-0461242IPR002859
DomainAlpha/beta_knot_MTases

SLC15A2 TARBP1

6.45e-0461242IPR029028
DomainREJ

PKD1L2 PKDREJ

6.45e-0461242PF02010
DomainETS_DOMAIN_1

ETS1 ETS2 ELF4

8.29e-04281243PS00345
DomainETS_DOMAIN_2

ETS1 ETS2 ELF4

8.29e-04281243PS00346
DomainEts

ETS1 ETS2 ELF4

8.29e-04281243PF00178
DomainETS

ETS1 ETS2 ELF4

8.29e-04281243SM00413
DomainEts_dom

ETS1 ETS2 ELF4

8.29e-04281243IPR000418
DomainETS_DOMAIN_3

ETS1 ETS2 ELF4

8.29e-04281243PS50061
DomainPH-BEACH_dom

NBEAL2 WDFY3

1.19e-0381242IPR023362
Domain-

NBEAL2 WDFY3

1.19e-03812422.30.29.40
DomainPH_BEACH

NBEAL2 WDFY3

1.19e-0381242PS51783
DomainPlexin_repeat

SEMA4B MEGF8 PLXNC1

1.23e-03321243IPR002165
DomainPSI

SEMA4B MEGF8 PLXNC1

1.23e-03321243PF01437
Domain-

SLC4A4 SLC4A9

1.53e-03912423.40.1100.10
DomainBEACH

NBEAL2 WDFY3

1.53e-0391242PS50197
DomainBeach

NBEAL2 WDFY3

1.53e-0391242PF02138
Domain-

NBEAL2 WDFY3

1.53e-03912421.10.1540.10
DomainBeach

NBEAL2 WDFY3

1.53e-0391242SM01026
DomainBand3_cytoplasmic_dom

SLC4A4 SLC4A9

1.53e-0391242IPR013769
DomainBand_3_cyto

SLC4A4 SLC4A9

1.53e-0391242PF07565
DomainBEACH_dom

NBEAL2 WDFY3

1.53e-0391242IPR000409
DomainPTrfase/Anion_transptr

SLC4A4 SLC4A9

1.90e-03101242IPR016152
DomainRap_GAP

RALGAPA1 RALGAPA2

1.90e-03101242PF02145
DomainHCO3_transpt_euk

SLC4A4 SLC4A9

1.90e-03101242IPR003020
DomainHCO3_cotransp

SLC4A4 SLC4A9

1.90e-03101242PF00955
DomainHCO3_transpt_C

SLC4A4 SLC4A9

1.90e-03101242IPR011531
DomainMFS_dom

MFSD6 SLC29A2 SLC15A2 CLN3 SLC22A1

2.01e-031341245IPR020846
DomainLeu-rich_rpt

FBXL17 LRRK1 NLRP2 OMG LRIG3 LRRC53 LRRC37B

2.23e-032711247IPR001611
DomainRap_GAP_dom

RALGAPA1 RALGAPA2

2.31e-03111242IPR000331
DomainPNT

ETS1 ETS2

2.31e-03111242PS51433
DomainSAM_PNT

ETS1 ETS2

2.31e-03111242PF02198
DomainRAPGAP

RALGAPA1 RALGAPA2

2.31e-03111242PS50085
DomainPKD_channel

PKD1L2 PKDREJ

2.31e-03111242PF08016
DomainPointed_dom

ETS1 ETS2

2.31e-03111242IPR003118
DomainPKD1_2_channel

PKD1L2 PKDREJ

2.31e-03111242IPR013122
DomainSAM_PNT

ETS1 ETS2

2.31e-03111242SM00251
DomainPSI

SEMA4B MEGF8 PLXNC1

3.10e-03441243IPR016201
DomainCarboxylesterase_B_CS

NLGN4Y NLGN4X

3.25e-03131242IPR019819
DomainPSI

SEMA4B MEGF8 PLXNC1

3.52e-03461243SM00423
Domain-

DCAF1 CLASP1 NEK10 RANBP17 ELMO2 WDFY3

3.68e-0322212461.25.10.10
DomainCARBOXYLESTERASE_B_2

NLGN4Y NLGN4X

3.78e-03141242PS00941
DomainCOesterase

NLGN4Y NLGN4X

3.78e-03141242PF00135
DomainCarbesteraseB

NLGN4Y NLGN4X

3.78e-03141242IPR002018
DomainLRR_TYP

LRRK1 OMG LRIG3 LRRC53 LRRC37B

6.57e-031771245SM00369
DomainLeu-rich_rpt_typical-subtyp

LRRK1 OMG LRIG3 LRRC53 LRRC37B

6.57e-031771245IPR003591
PathwayKEGG_DORSO_VENTRAL_AXIS_FORMATION

ETS1 ETS2 PIWIL4 SOS1

1.56e-0524914M11190
Pubmed

Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.

PRAMEF5 PRAMEF4 PKD1L2 NLRP2 PRAMEF11 PRAMEF6

1.34e-0930130638786026
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SEMA4B UBR4 HECTD4 LRRK1 RALGAPA2 SLC29A2 RYR1 FANCA THADA IGF2R MDN1 SHANK2 MEGF8 PLA2G4B CLN3 NBEAL2 SCN5A SEC16A WDFY3 ESPL1

5.68e-0911051302035748872
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

PRAMEF5 PRAMEF4 NLRP2 PRAMEF11 PRAMEF6

6.19e-0828130525089626
Pubmed

Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

4.27e-0717130423565261
Pubmed

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

4.27e-0717130437781892
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

5.48e-0718130423894331
Pubmed

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

5.48e-0718130439181896
Pubmed

Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

5.48e-0718130412890732
Pubmed

Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

5.48e-0718130429731491
Pubmed

Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

5.48e-0718130414675769
Pubmed

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

6.92e-0719130428604677
Pubmed

Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

8.62e-0720130426694250
Pubmed

Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

8.62e-0720130416580637
Pubmed

Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

8.62e-0720130421425410
Pubmed

CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.

DCAF1 CUL4A MCM10

1.01e-066130322570418
Pubmed

Nbeal2 interacts with Dock7, Sec16a, and Vac14.

NBEAL2 SEC16A DOCK7

1.01e-066130329187380
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

TMPPE PRAMEF5 HECTD4 ETS1 PRAMEF4 RALGAPA2 MDN1 GLIS2 PRAMEF11 PRAMEF6

1.19e-063631301014691545
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

1.29e-0622130431729367
Pubmed

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

1.56e-0623130419480014
Pubmed

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

2.22e-0625130412620990
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

2.22e-0625130437451217
Pubmed

Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

2.61e-0626130418500982
Pubmed

An abundance of X-linked genes expressed in spermatogonia.

PRAMEF5 PRAMEF4 STK31 PRAMEF11 PRAMEF6

2.88e-0659130511279525
Pubmed

Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.

DCAF1 CUL4A UBR4

4.22e-069130317855541
Pubmed

LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

6.18e-0632130437889087
Pubmed

Behavioral phenotypes of genetic mouse models of autism.

NLGN4Y SHANK2 NLGN4X

8.24e-0611130326403076
Pubmed

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

8.92e-0635130419389355
Pubmed

Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway.

XBP1 TICAM2 PYCARD

1.10e-0512130324489101
Pubmed

Transcriptional regulation of telomerase activity: roles of the the Ets transcription factor family.

ETS1 ETS2

1.39e-052130217986575
Pubmed

ETS-1 and ETS-2 are upregulated in a transgenic mouse model of pigmented ocular neoplasm.

ETS1 ETS2

1.39e-052130218958307
Pubmed

Ets-1 and Ets-2 protooncogene expression in theca cells of the adult mouse ovary.

ETS1 ETS2

1.39e-05213021511734
Pubmed

Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.

NLGN4Y NLGN4X

1.39e-052130223183221
Pubmed

Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism.

NLGN4Y NLGN4X

1.39e-052130224855039
Pubmed

Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder.

NLGN4Y NLGN4X

1.39e-052130237001827
Pubmed

c-ETS transcription factors play an essential role in the licensing of human MCM4 origin of replication.

ETS1 ETS2

1.39e-052130226365772
Pubmed

Unspliced XBP1 contributes to cholesterol biosynthesis and tumorigenesis by stabilizing SREBP2 in hepatocellular carcinoma.

SREBF2 XBP1

1.39e-052130235933495
Pubmed

An intricate arrangement of binding sites for the Ets family of transcription factors regulates activity of the alpha 4 integrin gene promoter.

ETS1 ETS2

1.39e-05213028195215
Pubmed

The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active.

ETS1 ETS2

1.39e-05213022997781
Pubmed

Differential expression of ets-1 and ets-2 proto-oncogenes during murine embryogenesis.

ETS1 ETS2

1.39e-05213028183549
Pubmed

Transcription factor Ets1, but not the closely related factor Ets2, inhibits antibody-secreting cell differentiation.

ETS1 ETS2

1.39e-052130224277931
Pubmed

The Ets family of proteins: weak modulators of gene expression in quest for transcriptional partners.

ETS1 ETS2

1.39e-05213028519813
Pubmed

Unusually rapid evolution of Neuroligin-4 in mice.

NLGN4Y NLGN4X

1.39e-052130218434543
Pubmed

Characterization and localization of the products of the human homologs of the v-ets oncogene.

ETS1 ETS2

1.39e-05213023285299
Pubmed

Increased Network Inhibition in the Dentate Gyrus of Adult Neuroligin-4 Knock-Out Mice.

NLGN4Y NLGN4X

1.39e-052130237080762
Pubmed

Mammalian ets-1 and ets-2 genes encode highly conserved proteins.

ETS1 ETS2

1.39e-05213022847145
Pubmed

Autism Related Neuroligin-4 Knockout Impairs Intracortical Processing but not Sensory Inputs in Mouse Barrel Cortex.

NLGN4Y NLGN4X

1.39e-052130229106499
Pubmed

Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism.

NLGN4Y NLGN4X

1.39e-052130226456829
Pubmed

Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro.

NLGN4Y NLGN4X

1.39e-052130224104404
Pubmed

The avian and mammalian ets genes: molecular characterization, chromosome mapping, and implication in human leukemia.

ETS1 ETS2

1.39e-05213023019221
Pubmed

A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.

NLGN4Y NLGN4X

1.39e-052130232243781
Pubmed

Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4.

NLGN4Y NLGN4X

1.39e-052130222989184
Pubmed

In vivo modulation of ETS genes induced by electromagnetic fields.

ETS1 ETS2

1.39e-052130211887334
Pubmed

Advancing the understanding of autism disease mechanisms through genetics.

NLGN4Y SHANK2 NLGN4X

1.42e-0513130327050589
Pubmed

Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis.

ETS1 ETS2 ELF4

1.80e-0514130314635793
Pubmed

Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

2.69e-0546130417287250
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

CLASP1 UBR4 SREBF2 XBP1 PKD1L2 MTNR1A SLC4A4 ESPL1

3.02e-05322130826514267
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

3.76e-0550130431806660
Pubmed

Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor.

CUL4A ETS1 ETS2

4.00e-0518130325117710
Pubmed

Physical interaction and functional synergy between glucocorticoid receptor and Ets2 proteins for transcription activation of the rat cytochrome P-450c27 promoter.

ETS1 ETS2

4.15e-053130211279115
Pubmed

Multifaceted activity of HIV Vpr/Vpx proteins: the current view of their virological functions.

DCAF1 CUL4A

4.15e-053130220069611
Pubmed

Ets-1 and Ets-2 regulate the expression of microRNA-126 in endothelial cells.

ETS1 ETS2

4.15e-053130220671229
Pubmed

Sp100 interacts with ETS-1 and stimulates its transcriptional activity.

ETS1 ETS2

4.15e-053130211909962
Pubmed

Inhibition of basal activity of c-jun-NH2-terminal kinase (JNK) represses the expression of presenilin-1 by a p53-dependent mechanism.

ETS1 ETS2

4.15e-053130218374905
Pubmed

An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 gene.

ETS1 ETS2

4.15e-05313021409581
Pubmed

A critical role of Sp1- and Ets-related transcription factors in maintaining CTL-specific expression of the mouse perforin gene.

ETS1 ETS2

4.15e-05313028871649
Pubmed

The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formation.

ETS1 ETS2

4.15e-05313027689222
Pubmed

Transcription factors Ets1, Ets2, and Elf1 exhibit differential localization in human endometrium across the menstrual cycle and alternate isoforms in cultured endometrial cells.

ETS1 ETS2

4.15e-053130210377039
Pubmed

Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage.

ETS1 ETS2

4.15e-053130210375504
Pubmed

Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress.

ETS1 XBP1

4.15e-053130221423203
Pubmed

Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases.

RALGAPA1 RALGAPA2

4.15e-053130219520869
Pubmed

Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents.

NLGN4Y NLGN4X

4.15e-053130232011705
Pubmed

Conserved chromosomal positions of dual domains of the ets protooncogene in cats, mice, and humans.

ETS1 ETS2

4.15e-05313023513188
Pubmed

HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase.

DCAF1 CUL4A

4.15e-053130217314515
Pubmed

Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis.

ETS1 ETS2

4.15e-053130221989915
Pubmed

The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation.

NLRP2 PYCARD

4.15e-053130211250163
Pubmed

Analysis of the neuroligin 4Y gene in patients with autism.

NLGN4Y NLGN4X

4.15e-053130218628683
Pubmed

HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase.

DCAF1 CUL4A

4.15e-053130219667756
Pubmed

Transactivation of the Moloney murine leukemia virus and T-cell receptor beta-chain enhancers by cbf and ets requires intact binding sites for both proteins.

ETS1 ETS2

4.15e-05313027609063
Pubmed

HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase.

DCAF1 CUL4A

4.15e-053130217630831
Pubmed

Regulation of the human interleukin-5 promoter by Ets transcription factors. Ets1 and Ets2, but not Elf-1, cooperate with GATA3 and HTLV-I Tax1.

ETS1 ETS2

4.15e-053130210212281
Pubmed

Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.

NLGN4Y NLGN4X

4.15e-053130221282647
Pubmed

Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus.

ETS1 ETS2

4.15e-05313022163347
Pubmed

MicroRNA 17-92 cluster mediates ETS1 and ETS2-dependent RAS-oncogenic transformation.

ETS1 ETS2

4.15e-053130224968297
Pubmed

Involvement of the proto-oncogene c-ets 1 and the urokinase plasminogen activator during mouse implantation and placentation.

VWF ETS1

4.15e-05313028179996
Pubmed

HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest.

DCAF1 MCM10

4.15e-053130226032416
Pubmed

Interaction with ZMYND11 mediates opposing roles of Ras-responsive transcription factors ETS1 and ETS2.

ETS1 ETS2

4.15e-053130228119415
Pubmed

ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

6.76e-0558130431598710
Pubmed

Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain.

DCAF1 SEC16A DOCK7

7.46e-0522130326950368
Pubmed

Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection.

DCAF1 CUL4A

8.28e-054130218464893
Pubmed

The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor.

DCAF1 CUL4A

8.28e-054130217620334
Pubmed

IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells.

ETS1 ETS2

8.28e-054130210815800
Pubmed

DCAF1 (VprBP): emerging physiological roles for a unique dual-service E3 ubiquitin ligase substrate receptor.

DCAF1 CUL4A

8.28e-054130230590706
Pubmed

Modulation of NKG2D-mediated cytotoxic functions of natural killer cells by viral protein R from HIV-1 primary isolates.

DCAF1 CUL4A

8.28e-054130221957298
Pubmed

Transcriptional regulation of the apolipoprotein F (ApoF) gene by ETS and C/EBPα in hepatoma cells.

ETS1 ETS2

8.28e-054130225726912
Pubmed

Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1).

NEDD9 SOS1

8.28e-05413029162067
Pubmed

The SAM domain of human TEL2 can abrogate transcriptional output from TEL1 (ETV-6) and ETS1/ETS2.

ETS1 ETS2

8.28e-054130222615925
Pubmed

Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation.

ETS1 ETS2

8.28e-054130226389665
Pubmed

Hepatitis B virus-X protein upregulates the expression of p21waf1/cip1 and prolongs G1-->S transition via a p53-independent pathway in human hepatoma cells.

ETS1 ETS2

8.28e-054130210918595
Pubmed

Regulation of CSF-1 receptor expression.

ETS1 ETS2

8.28e-05413028981363
Pubmed

An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells.

NUP98 NUP133

8.28e-054130211564755
Cytoband1p36.21

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

3.21e-056313041p36.21
GeneFamilyPRAME family

PRAMEF5 PRAMEF4 PRAMEF11 PRAMEF6

5.17e-0624884686
GeneFamilyETS transcription factor family

ETS1 ETS2 ELF4

3.34e-0428883534
GeneFamilyWD repeat domain containing|BEACH domain containing

NBEAL2 WDFY3

8.25e-0498821230
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NLGN4Y DNER RANBP17 SHANK2 TMEM150C EEF1AKMT2 RP1

5.17e-0716412971cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SEMA4B SREBF2 USP44 LRIG3 SHANK2 SLC4A4

1.26e-0517612963bbac5c2397535631fce8fa98f6ddb4fe0260351
ToppCellmoderate-Myeloid-Neutrophil|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

GPR65 ETS2 IFITM1 HCAR3 PLXNC1 ABTB1

2.06e-0519212968105408400dac5dcb0ce62b558433257559c9f09
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NEK10 SHANK2 KITLG NBEAL2 KDM7A VWA5B1

2.18e-05194129604bfc555743f7d8821439d05ae442d15e9886c59
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NEK10 SHANK2 KITLG NBEAL2 KDM7A VWA5B1

2.18e-05194129669bff17df4a760ccf081cf52ff04af02c14f448d
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SREBF2 XBP1 SHANK2 SLC15A2 TMEM150C SLC4A4

2.44e-0519812966ba5e5970109a04ed968bac7ff099ae250c579dc
ToppCellNS-control-d_0-4-Epithelial-Secretory|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NCKAP1 XBP1 RANBP17 LRIG3 SLC15A2 SLC4A4

2.51e-05199129632bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Basal_3-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ETS2 IFITM1 RYR1 NEDD9 HCAR3 SLC4A4

2.59e-05200129641705bbba40eb5ddca0b223191aac1bce00163b8
ToppCell10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_granulocytic-neutrophil|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

IFITM1 RALGAPA2 IGF2R PLXNC1 ABTB1 WDFY3

2.59e-0520012966beabd5bad042d4d65c89c2f537c7376230f7c08
ToppCellTracheal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SREBF2 XBP1 RALGAPA2 RANBP17 LRIG3 SHANK2

2.59e-052001296d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCellParenchyma_COVID-19-Epithelial-TX-Basal_3|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

ETS2 IFITM1 RYR1 NEDD9 HCAR3 SLC4A4

2.59e-05200129653e04399d0308b40ae99fbfaa4ff62bf061822d8
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Basal_3|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ETS2 IFITM1 RYR1 NEDD9 HCAR3 SLC4A4

2.59e-052001296cc8df398532c9324fd3e171000b1ea5c208cd691
ToppCell10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_granulocytic|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

IFITM1 RALGAPA2 IGF2R PLXNC1 ABTB1 WDFY3

2.59e-052001296026495aa7f1e7528a01d9199475cfc393677fc60
DrugAC1L1FET

GBA3 KITLG GLCE ELF4

6.25e-06221274CID000003205
Drug0179445-0000 [211246-22-9]; Down 200; 10uM; MCF7; HT_HG-U133A

CUL4A HECTD4 NUP98 KRIT1 SHANK2 SLC15A2 CENPI ESPL1

9.60e-0618512784755_DN
Drugm-7a

RYR1 GBA3 ELF4

1.39e-0591273CID000029558
DrugMoroxidine hydrochloride [3160-91-6]; Up 200; 19.2uM; PC3; HG-U133A

CUL4A NCKAP1 NUP98 ETS2 KRIT1 CENPI SLC4A4 TARBP1

1.41e-0519512781944_UP
DrugTiclopidine hydrochloride [53885-35-1]; Up 200; 13.4uM; HL60; HG-U133A

ETS2 FPGT SLC29A2 OMG KRIT1 IGF2R MDN1 ELMO2

1.57e-0519812781975_UP
DrugClopamide [636-54-4]; Up 200; 11.6uM; HL60; HG-U133A

OMG FANCA TAS2R1 NBEAL2 SCN5A ALOXE3 KDM7A SLC4A4

1.63e-0519912781605_UP
DiseaseX-11261 measurement

IGF2R SLC22A1

4.83e-0531192EFO_0021221
DiseaseX-24422 measurement

IGF2R SLC22A1

4.83e-0531192EFO_0800880
Diseasecation-independent mannose-6-phosphate receptor measurement

IGF2R SLC22A1

9.63e-0541192EFO_0008075
Diseaseurate measurement, bone density

DNER ETS1 ETS2 DNAH14 FANCA NEDD9 RANBP17 PLXNC1 GLIS2 SEC16A

2.11e-0461911910EFO_0003923, EFO_0004531
DiseaseAutism spectrum disorder

SHANK2 NLGN4X

3.34e-0471192cv:C1510586
Diseaseacisoga measurement

IGF2R SLC22A1

3.34e-0471192EFO_0800068
Diseaseargininate measurement

IGF2R SLC22A1

4.44e-0481192EFO_0800055
Diseasepimeloylcarnitine/3-methyladipoylcarnitine (C7-DC) measurement

IGF2R SLC22A1

4.44e-0481192EFO_0800494
Diseasesurvival time

MCM10 CYP39A1

5.70e-0491192EFO_0000714
DiseaseX-11381 measurement

IGF2R SLC22A1

5.70e-0491192EFO_0021228
Diseaseresponse to angiotensin-converting enzyme inhibitor, Cough

CLASP1 PKD1L2 NEDD9

8.55e-04461193EFO_0005325, HP_0012735
Diseasediastolic blood pressure, systolic blood pressure

MTERF1 NEK10 FBXL17 SYT10 LRIG3 PLXNC1 SCN5A SEC16A SLC35E3

1.61e-036701199EFO_0006335, EFO_0006336
DiseaseProteinuria

VWF FAM151B

1.64e-03151192HP_0000093
Diseaseanemia (implicated_via_orthology)

SLC4A4 SLC4A9

1.64e-03151192DOID:2355 (implicated_via_orthology)
Diseaseneutrophil count, eosinophil count

HECTD4 ETS1 THADA KITLG ZNF292

1.75e-032131195EFO_0004833, EFO_0004842
Diseaseneutrophil count, basophil count

HECTD4 ETS1 THADA KITLG ZNF292

2.18e-032241195EFO_0004833, EFO_0005090
Diseaseulcerative colitis

RNF186 GPR65 UBR4 ETS1 FBXL17 EEF1AKMT2

2.43e-033351196EFO_0000729
Diseasefactor VIII measurement, Ischemic stroke

VWF HECTD4

2.64e-03191192EFO_0004630, HP_0002140
Diseaseautism spectrum disorder (implicated_via_orthology)

NLGN4Y SHANK2 NLGN4X WDFY3

3.40e-031521194DOID:0060041 (implicated_via_orthology)
Diseasegranulocyte count

HECTD4 ETS1 THADA KITLG ZNF292

3.74e-032541195EFO_0007987

Protein segments in the cluster

PeptideGeneStartEntry
TELAFESQLWLCVQL

ARSF

181

P54793
WTCKDLLLQALRESQ

PYCARD

171

Q9ULZ3
IQLACLGLLWIIKST

SLC4A9

891

Q96Q91
LNECSWSLNILAINK

NEDD9

506

Q14511
WKEQTLLCLLQLIHL

DEPDC4

236

Q8N2C3
ICALFTLVTVLLWNK

GLCE

16

O94923
LQLCALTQAVSKLWV

AMN

11

Q9BXJ7
CNEKIELAILWFLDQ

RANBP17

541

Q9H2T7
LLKLSCTDTTINEWL

OR5I1

186

Q13606
LITNSFVECNRLLKW

ARIH1

261

Q9Y4X5
LEILCKALQRDNWSS

NUP133

1071

Q8WUM0
CVQLLLQLISIACNW

DCAF1

596

Q9Y4B6
DCKWNTLSITDDLLL

DGKK

376

Q5KSL6
INVCSQLDWKRSLAI

NUP98

1416

P52948
LSVLKLACADTWLNQ

OR2A14

181

Q96R47
AICWFVAKNLLETLK

KDM7A

401

Q6ZMT4
QCQILLEQLSWLLQC

MDN1

4296

Q9NU22
NIIFCDLKSDNILVW

LRRK1

1381

Q38SD2
LNTSSLLCDCQLKWL

LRIG3

441

Q6UXM1
LWEFLLALLQDRNTC

ELF4

211

Q99607
EVNISCNNLLLFWLV

ALOXE3

631

Q9BYJ1
LILLSLDKNQWSCTC

LRRC53

206

A6NM62
CTRIWSKENLLALNT

ATXN8OS

136

P0DMR3
QKASLWKLDLCTTVL

KATNB1

546

Q9BVA0
QLWQFLLELLTDKSC

ETS1

336

P14921
ITCKALYTLNEDWLL

PLXNC1

1176

O60486
FTEERLWKIFIQLCL

NEK10

626

Q6ZWH5
WQFLLELLSDKSCQS

ETS2

366

P15036
ALVRQSCSQLLWLLK

FAM151B

206

Q6UXP7
LFLSLCVLLWKAKQA

MEGF8

2661

Q7Z7M0
CNLITKLSLGTFQAW

LRRC37B

636

Q96QE4
FTIWICSENLSLQLK

KRIT1

461

O00522
ECKLQTLVLWNCDIT

NLRP2

896

Q9NX02
SIWKLNDLRDLTQCV

MCM10

316

Q7L590
SCFTNLWALINEALL

PLA2G4B

396

P0C869
RWAKCNQLFELLQDL

GLIS2

171

Q9BZE0
WQVCKELQSSSLSLL

HECTD4

3656

Q9Y4D8
QAFNFWDLIKLLCSV

MFSD6

431

Q6ZSS7
RLFLLWLQALQTNCA

RALGAPA2

131

Q2PPJ7
CWLNENFRIELKALL

GPR83

346

Q9NYM4
NLWKLALQSSSCLSL

NCKAP1

281

Q9Y2A7
FCSKWNLLELAIILA

PKD1L2

2216

Q7Z442
SLLLCQEDWNITDFL

GRIN3A

266

Q8TCU5
ILSVLKLACADTWLN

OR2A5

181

Q96R48
LNSNVLLWITALAIK

NLGN4Y

21

Q8NFZ3
KKWQLIIQLFATCFL

B3GNT5

11

Q9BYG0
LSKQFVQWDELLCQL

DCTN3

161

O75935
KQLQLPDTLSSLLCW

ATP11AUN

81

Q6ZP68
DKAQALLWLYICTLE

ESPL1

676

Q14674
CLLWVLKNADETVLQ

DOCK7

1331

Q96N67
KWFTDLSVLQLNRLL

DOCK7

1346

Q96N67
TLQQKVFILFLTLWL

GCNT4

11

Q9P109
DLNCLSDLLKSSIQW

GCNT4

206

Q9P109
LDKVNLQVYCAWSLL

GBA3

406

Q9H227
EELFGICIQLLNKTW

ELMO2

446

Q96JJ3
FFLITSCNWTKEELL

EEF1AKMT2

186

Q5JPI9
KNLSSLNLCLNWIIN

FBXL17

566

Q9UF56
FCQELWKIQSSLLLE

FANCA

166

O15360
LDSVLFLKKINTCWQ

CUL4A

126

Q13619
FSLLCKSLLSNVSQW

DNAH14

2901

Q0VDD8
EFCLAVLTAVLQWKQ

MS4A6E

131

Q96DS6
LCNIWDNTLLQLVLV

HUS1B

251

Q8NHY5
DLENLLLIKWCVLET

CYP39A1

321

Q9NYL5
EQLAILKSFFLQCQW

HOMEZ

366

Q8IX15
CSVLQSLKELLQNWL

CENPI

491

Q92674
LILLWKVTATGFQQC

DNER

236

Q8NFT8
QWAEFILFSCLLLVI

SLC15A2

671

Q16348
WFQKQAFLILCLLSA

SLC22A1

16

O15245
CALFSTNLDWLVSKL

RYR1

536

P21817
LNSNVLLWLTALAIK

NLGN4X

21

Q8N0W4
LSCLDVWNLKVTEEL

FPGT

511

O14772
ICNSSTNLLLAWLLV

RP1

1121

P56715
TAKCLNIWALILGIL

IFITM1

81

P13164
ILWFNLKEIDFKACL

OR52N1

86

Q8NH53
QVFALLAQETLWDLC

FAM180B

146

Q6P0A1
KLLTWLSVLECVEVF

PEX16

81

Q9Y5Y5
CLKLLLCVQDNTWSI

RNF186

66

Q9NXI6
LISLDKQTCTLFFSW

IGF2R

1626

P11717
CNKIWNALRFILNAL

VARS2

746

Q5ST30
AAELKQWVQLVILSC

THADA

1676

Q6YHU6
LELQDTLALWKCVLT

THADA

1721

Q6YHU6
TLALWKCVLTLLQSE

THADA

1726

Q6YHU6
VFQKIWLTALCLVLV

SLC29A2

286

Q14542
QTLSFLKQEALLSLW

TMEM132E

716

Q6IEE7
LFICQKWLSVDTTLD

PKDREJ

1326

Q9NTG1
LNKISNWTAAIISCL

HCAR3

136

P49019
ELCNLLTNVLFSVTW

NBEAL2

1441

Q6ZNJ1
LQQRWTSFLKAQLLC

SEMA4B

296

Q9NPR2
CKILNAQSLNTWLIL

PIWIL4

476

Q7Z3Z4
NVLLVCLIFWLIFSI

SCN5A

1336

Q14524
TWILTCIYLQLLLFN

KITLG

6

P21583
ILLLTENFLRDTWCN

TICAM2

136

Q86XR7
LAVLTLQIQSLISCW

XBP1

191

P17861
TLTCWIQAALTLKVN

TMEM150C

141

B9EJG8
LTLWFEKCIVETENL

SOS1

831

Q07889
SLALLCQWIQSKLQE

OMA1

366

Q96E52
AWKVNASFLLLLNVV

OMG

421

P23515
WVAKQRILCTLTQSL

SHANK2

81

Q9UPX8
LAKQCQLWDLLSDLE

ABTB1

191

Q969K4
WALALLQCLNLVFLL

CLN3

346

Q13286
DLQDWLFVLLTQLLK

CLASP1

931

Q7Z460
NCAILLFINELELWL

TAS2R1

81

Q9NYW7
CLLLWLSVQNQEFEI

STK31

916

Q9BXU1
FSIECVLYLWSLKIN

PPP3CC

121

P48454
WLKNRTLDEYLTCLL

PRAMEF4

156

O60810
TLDEYLTCLLLWVKQ

PRAMEF4

161

O60810
KNRTLDEYLTCLLLW

PRAMEF6

156

Q5VXH4
VLCQGFLNLLLWDLE

TCP11

291

Q8WWU5
NLTLIWCVVLKLASL

TMC8

371

Q8IU68
CIIWDLNKLSFLTQL

WDFY3

3151

Q8IZQ1
LFLLWLQALQNNCSK

RALGAPA1

131

Q6GYQ0
LWEQCQLLKSTSVFA

VWF

221

P04275
KESASLLWNFIVLLC

SEC16A

1531

O15027
SLTLRTLWEKNCQVL

PLCXD2

196

Q0VAA5
CDLLLSLRTALWQKQ

SREBF2

976

Q12772
KNRTLDEYLTCLLLW

PRAMEF5

156

Q5TYX0
NSLRCELLLVLKTQW

ZNF292

426

O60281
CNLSTLNITLLSWSK

MTERF1

371

Q99551
WLKNRTLDEYLTCLL

PRAMEF11

156

O60813
TLDEYLTCLLLWVKQ

PRAMEF11

161

O60813
LEKWQINLNLFRTCT

GPR65

176

Q8IYL9
LALLVVSLFVFWKLC

SYT10

66

Q6XYQ8
SWKILLFGVINLICT

SLC30A6

31

Q6NXT4
LQVLCLALLWILKST

SLC4A4

956

Q9Y6R1
LILKQALIVVLQWCF

TARBP1

1266

Q13395
ISRDTKNWKIILCLF

TRPM8

686

Q7Z2W7
FILVLCWILNTLVNI

VN1R3

131

Q9BXE9
AWCLLNSLFLILNLS

UBR4

411

Q5T4S7
FSKTQILYVVLWLLC

PTDSS1

376

P48651
NLLVSICIVFLNKWI

SLC35E3

21

Q7Z769
IFRQCFLKLDLNQWL

USP44

296

Q9H0E7
SWNKLCLATLLNTEV

VWA5B1

201

Q5TIE3
QFLLAILWLQLSCVS

TRAV41

6

A0A0B4J266
ILWLQLSCVSAAKNE

TRAV41

11

A0A0B4J266
CFQLWKVVVLAFLAL

TMPPE

81

Q6ZT21
SKNSLCYVLLIWLLT

MTNR1A

141

P48039
TVLFDLEALLKIWCL

NALCN

426

Q8IZF0