Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	intramolecular oxidoreductase activity, transposing S-S bonds	PDIA3 PDIA4 QSOX1 TMX3	2.53e-05	22	159	4	GO:0016864
GeneOntologyMolecularFunction	protein disulfide isomerase activity	PDIA3 PDIA4 QSOX1 TMX3	2.53e-05	22	159	4	GO:0003756
GeneOntologyMolecularFunction	scaffold protein binding	GRIN2A CHRNA7 DYNLL2 KCNQ1 DYNLL1 CHRFAM7A	9.99e-05	93	159	6	GO:0097110
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing O-glycosyl compounds	HEXA SI KL NEU2 GANAB OTOGL	1.75e-04	103	159	6	GO:0004553
GeneOntologyMolecularFunction	protein-disulfide reductase activity	PDIA3 PDIA4 QSOX1 TMX3	1.87e-04	36	159	4	GO:0015035
GeneOntologyMolecularFunction	glucosidase activity	SI KL GANAB	2.10e-04	15	159	3	GO:0015926
GeneOntologyMolecularFunction	adenylate cyclase binding	ADCY2 CHRNA7 CHRFAM7A	2.57e-04	16	159	3	GO:0008179
GeneOntologyMolecularFunction	toxic substance binding	CHRNA7 ASS1 CHRFAM7A	3.70e-04	18	159	3	GO:0015643
GeneOntologyMolecularFunction	disulfide oxidoreductase activity	PDIA3 PDIA4 QSOX1 TMX3	3.75e-04	43	159	4	GO:0015036
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure	ARHGAP42 UTS2R CHRNA7 KL PTPRO KDR CHRFAM7A	4.82e-05	124	158	7	GO:0003073
GeneOntologyBiologicalProcess	positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure	CHRNA7 CHRFAM7A	5.83e-05	2	158	2	GO:0001988
GeneOntologyBiologicalProcess	negative regulation of axon guidance	SLIT2 PTPRO	5.83e-05	2	158	2	GO:1902668
GeneOntologyBiologicalProcess	negative regulation of retinal ganglion cell axon guidance	SLIT2 PTPRO	5.83e-05	2	158	2	GO:0090260
MousePheno	absent organized vascular network	PIEZO1 PTPRB KDR	3.35e-05	8	120	3	MP:0000263
MousePheno	airway basal cell hyperplasia	CHRNA7 CHRFAM7A	7.31e-05	2	120	2	MP:0011115
MousePheno	abnormal airway basal cell differentiation	CHRNA7 CHRFAM7A	7.31e-05	2	120	2	MP:0011114
MousePheno	abnormal airway basal cell morphology	CHRNA7 CHRFAM7A	7.31e-05	2	120	2	MP:0011113
MousePheno	small stapes obturator foramen	CHD7 KL	7.31e-05	2	120	2	MP:0030405
MousePheno	decreased circulating glucose level	ATR SPTSSB AKR1D1 JMJD4 BCAT2 SI SETD4 SVEP1 ELMO1 SOCS7 TIPARP QSOX1 KL GYS2 DYNLL1 HERC1 GOT1	8.30e-05	691	120	17	MP:0005560
Domain	Disulphide_isomerase	PDIA3 PDIA4 TMX3	3.16e-05	8	157	3	IPR005788
Domain	Dynein_light_1/2_CS	DYNLL2 DYNLL1	7.02e-05	2	157	2	IPR019763
Domain	Thioredoxin	PDIA3 PDIA4 QSOX1 TMX3	1.27e-04	31	157	4	PF00085
Domain	Thioredoxin	PDIA3 PDIA4 TMX3	1.57e-04	13	157	3	IPR005746
Domain	Dynein_light	DYNLL2 DYNLL1	2.09e-04	3	157	2	PF01221
Domain	DYNEIN_LIGHT_1	DYNLL2 DYNLL1	2.09e-04	3	157	2	PS01239
Domain	Dynein_light	DYNLL2 DYNLL1	2.09e-04	3	157	2	SM01375
Domain	Dynein_light_chain_typ-1/2	DYNLL2 DYNLL1	2.09e-04	3	157	2	IPR001372
Domain	-	DYNLL2 DYNLL1	2.09e-04	3	157	2	3.30.740.10
Domain	Thioredoxin_CS	PDIA3 PDIA4 TMX3	3.63e-04	17	157	3	IPR017937
Domain	Thioredoxin_domain	PDIA3 PDIA4 QSOX1 TMX3	3.82e-04	41	157	4	IPR013766
Domain	Ion_trans_N	HCN4 HCN1	4.17e-04	4	157	2	IPR013621
Domain	Glyco_hydro_31_CS	SI GANAB	4.17e-04	4	157	2	IPR030459
Domain	Ion_trans_N	HCN4 HCN1	4.17e-04	4	157	2	PF08412
Domain	Prot_disulphide_isomerase	PDIA3 PDIA4	4.17e-04	4	157	2	IPR005792
Domain	Calsequestrin	PDIA4 TMX3	4.17e-04	4	157	2	IPR001393
Domain	PRY	TRIM27 RFPL1 TRIM50 RFPL3	4.19e-04	42	157	4	PF13765
Domain	THIOREDOXIN_2	PDIA3 PDIA4 QSOX1 TMX3	4.59e-04	43	157	4	PS51352
Domain	ConA-like_dom	ZAN TRIM27 RFPL1 SVEP1 SLIT2 TRIM50 HERC1 RFPL3	5.39e-04	219	157	8	IPR013320
Domain	C1-set_C	HLA-DPA1 HLA-DQA2	6.91e-04	5	157	2	PF16196
Domain	GLYCOSYL_HYDROL_F31_2	SI GANAB	6.91e-04	5	157	2	PS00707
Domain	MHC_II_alpha	HLA-DPA1 HLA-DQA2	6.91e-04	5	157	2	SM00920
Domain	RDM_domain_RFPL	RFPL1 RFPL3	6.91e-04	5	157	2	IPR022723
Domain	RDM	RFPL1 RFPL3	6.91e-04	5	157	2	PF11002
Domain	C1-set_C	HLA-DPA1 HLA-DQA2	6.91e-04	5	157	2	IPR032431
Domain	PRY	TRIM27 RFPL1 TRIM50 RFPL3	7.01e-04	48	157	4	SM00589
Domain	PRY	TRIM27 RFPL1 TRIM50 RFPL3	7.01e-04	48	157	4	IPR006574
Domain	SPRY	TRIM27 RFPL1 TRIM50 HERC1 RFPL3	8.36e-04	87	157	5	SM00449
Domain	Glycoside_hydrolase_SF	HEXA SI KL GANAB	1.02e-03	53	157	4	IPR017853
Domain	Glyco_hydro_31_AS	SI GANAB	1.03e-03	6	157	2	IPR030458
Domain	MHC_II_alpha	HLA-DPA1 HLA-DQA2	1.03e-03	6	157	2	PF00993
Domain	THIOREDOXIN_1	PDIA3 PDIA4 TMX3	1.17e-03	25	157	3	PS00194
Domain	SPRY	TRIM27 RFPL1 TRIM50 HERC1 RFPL3	1.18e-03	94	157	5	PF00622
Domain	SPRY_dom	TRIM27 RFPL1 TRIM50 HERC1 RFPL3	1.18e-03	94	157	5	IPR003877
Domain	B30.2/SPRY	TRIM27 RFPL1 TRIM50 HERC1 RFPL3	1.24e-03	95	157	5	IPR001870
Domain	B302_SPRY	TRIM27 RFPL1 TRIM50 HERC1 RFPL3	1.24e-03	95	157	5	PS50188
Domain	-	TDP2 EEPD1 INPP5J	1.31e-03	26	157	3	3.60.10.10
Domain	Exo_endo_phos	TDP2 EEPD1 INPP5J	1.31e-03	26	157	3	PF03372
Domain	Glyco_hydro_31	SI GANAB	1.43e-03	7	157	2	IPR000322
Domain	Glyco_hydro_31	SI GANAB	1.43e-03	7	157	2	PF01055
Domain	MHC_II_a_N	HLA-DPA1 HLA-DQA2	1.43e-03	7	157	2	IPR001003
Domain	GLYCOSYL_HYDROL_F31_1	SI GANAB	1.43e-03	7	157	2	PS00129
Domain	Endo/exonuclease/phosphatase	TDP2 EEPD1 INPP5J	1.47e-03	27	157	3	IPR005135
Pubmed	Cloning and mapping of the mouse alpha 7-neuronal nicotinic acetylcholine receptor.	GAS2 CHRNA7 CHRFAM7A	9.67e-07	5	161	3	7601470
Pubmed	Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation.	PDIA3 PDIA4 TMX3	1.93e-06	6	161	3	19995400
Pubmed	Shaking the family tree: identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors.	KLF8 KLF4 KLF7	1.93e-06	6	161	3	23134681
Pubmed	Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms.	GAS2 CHRNA7 CHRFAM7A	1.93e-06	6	161	3	9602068
Pubmed	Nicotine regulates multiple synaptic proteins by inhibiting proteasomal activity.	GRIN2A CHRNA7 CHRFAM7A	3.36e-06	7	161	3	17898222
Pubmed	Beta-catenin (CTNNB1) induces Bmp expression in urogenital sinus epithelium and participates in prostatic bud initiation and patterning.	CHRNA7 BMP2 CHRFAM7A	1.56e-05	11	161	3	23396188
Pubmed	Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes.	KLF8 KLF4 KLF7	2.08e-05	12	161	3	15937668
Pubmed	Enhancing cognitive function in chronic TBI: The Role of α7 nicotinic acetylcholine receptor modulation.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	38070724
Pubmed	Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	34453977
Pubmed	Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	26999808
Pubmed	Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	27129924
Pubmed	CXCR7 regulates epileptic seizures by controlling the synaptic activity of hippocampal granule cells.	GRIN2A ACKR3	2.13e-05	2	161	2	31672961
Pubmed	Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	23521765
Pubmed	Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	28258105
Pubmed	The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	19344760
Pubmed	Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	29114104
Pubmed	Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	33995108
Pubmed	E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	32552811
Pubmed	Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	24836856
Pubmed	Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	15948184
Pubmed	Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	35678315
Pubmed	Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	12628457
Pubmed	Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	25157794
Pubmed	Mesenchymal Stem Cells or Interleukin-6 Improve Episodic Memory of Mice Lacking α7 Nicotinic Acetylcholine Receptors.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	31202708
Pubmed	Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	22246862
Pubmed	Activation of Nicotinic Acetylcholine Receptors Decreases Apoptosis in Human and Female Murine Pancreatic Islets.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	27471776
Pubmed	Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	22688057
Pubmed	Different Effects of Nicotine and N-Stearoyl-ethanolamine on Episodic Memory and Brain Mitochondria of α7 Nicotinic Acetylcholine Receptor Knockout Mice.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	32028688
Pubmed	Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	30429582
Pubmed	A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neurons.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	21501254
Pubmed	Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	21368056
Pubmed	Formyl Peptide Receptor 1 Modulates Endothelial Cell Functions by NADPH Oxidase-Dependent VEGFR2 Transactivation.	ATR KDR	2.13e-05	2	161	2	29743977
Pubmed	Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	1400473
Pubmed	Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood-Brain Barrier Permeability following Experimental Traumatic Brain Injury.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	26937017
Pubmed	Diminished α7 nicotinic acetylcholine receptor (α7nAChR) rescues amyloid-β induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated mitochondrial oxidative stress.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	36603528
Pubmed	Activation of α7nAChR Promotes Diabetic Wound Healing by Suppressing AGE-Induced TNF-α Production.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	26650489
Pubmed	Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	22848433
Pubmed	Peripheral N- and C-terminal domains determine deactivation kinetics of HCN channels.	HCN4 HCN1	2.13e-05	2	161	2	17548059
Pubmed	Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	16650968
Pubmed	Microglial cell response in α7 nicotinic acetylcholine receptor-deficient mice after systemic infection with Escherichia coli.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	35413868
Pubmed	Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	24462939
Pubmed	Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	29261717
Pubmed	Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous mice.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	18199426
Pubmed	Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	22490926
Pubmed	Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	23270857
Pubmed	Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	18077004
Pubmed	Affinity, avidity, and kinetics of target sequence binding to LC8 dynein light chain isoforms.	DYNLL2 DYNLL1	2.13e-05	2	161	2	20889982
Pubmed	Smoking in adult attention-deficit/hyperactivity disorder: interaction between 15q13 nicotinic genes and Temperament Character Inventory scores.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	19462340
Pubmed	Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes.	HLA-DPA1 HLA-DQA2	2.13e-05	2	161	2	6300884
Pubmed	Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	16923147
Pubmed	NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	11790782
Pubmed	Genetic deletion of α7 nAChRs reduces hippocampal granule and pyramidal cell number in both sexes but impairs pattern separation in males only.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	37746145
Pubmed	PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells.	KLF4 PARP1	2.13e-05	2	161	2	28985359
Pubmed	A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	19631623
Pubmed	Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	15770102
Pubmed	Cortical synaptic NMDA receptor deficits in α7 nicotinic acetylcholine receptor gene deletion models: implications for neuropsychiatric diseases.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	24326163
Pubmed	Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis.	PTPRB KDR	2.13e-05	2	161	2	19136612
Pubmed	Functional role of alpha7 nicotinic receptor in chronic neuropathic and inflammatory pain: studies in transgenic mice.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	23811428
Pubmed	Alpha 7 subunit of nAChR regulates migration of human mesenchymal stem cells.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	20720594
Pubmed	Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	17019565
Pubmed	Dilinoleoylphosphatidylcholine ameliorates scopolamine-induced impairment of spatial learning and memory by targeting alpha7 nicotinic ACh receptors.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	19100751
Pubmed	Activation of the α7 Nicotinic Acetylcholine Receptor Prevents against Microglial-Induced Inflammation and Insulin Resistance in Hypothalamic Neuronal Cells.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	35883638
Pubmed	Chrna7 genotype is linked with alpha7 nicotinic receptor expression but not alpha7 RNA levels.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	19368846
Pubmed	Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	15009674
Pubmed	Hydroxynorketamine, but not ketamine, acts via α7 nicotinic acetylcholine receptor to control presynaptic function and gene expression.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	38253622
Pubmed	The role of dorsal root ganglia alpha-7 nicotinic acetylcholine receptor in complete Freund's adjuvant-induced chronic inflammatory pain.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	34514543
Pubmed	α7 nicotinic acetylcholine receptor (α7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	22183893
Pubmed	Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	9364063
Pubmed	Evidence suggesting that the mouse sperm acrosome reaction initiated by the zona pellucida involves an alpha7 nicotinic acetylcholine receptor.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	12606407
Pubmed	Genetic variations in CHRNA7 or CHRFAM7 and susceptibility to dementia.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	22300029
Pubmed	GTS-21 ameliorates polymicrobial sepsis-induced hepatic injury by modulating autophagy through α7nAchRs in mice.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	32018068
Pubmed	CHRNA7 and CHRFAM7A mRNAs: co-localized and their expression levels altered in the postmortem dorsolateral prefrontal cortex in major psychiatric disorders.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	26206074
Pubmed	Nicotine elicits prolonged calcium signaling along ventral hippocampal axons.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	24349346
Pubmed	The role of nicotinic acetylcholine receptor (nAChR) α7 subtype in the functional interaction between nicotine and ethanol in mouse cerebellum.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	21143250
Pubmed	Cholinergic modulation of appetite-related synapses in mouse lateral hypothalamic slice.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	16319313
Pubmed	Impaired synaptic plasticity in the visual cortex of mice lacking α7-nicotinic receptor subunit.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	25797465
Pubmed	Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	29197398
Pubmed	Cholinergic signaling via the α7 nicotinic acetylcholine receptor regulates the migration of monocyte-derived macrophages during acute inflammation.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	38178134
Pubmed	In hippocampal oriens interneurons anti-Hebbian long-term potentiation requires cholinergic signaling via α7 nicotinic acetylcholine receptors.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	23325242
Pubmed	Glutamatergic synapse formation is promoted by α7-containing nicotinic acetylcholine receptors.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	22649244
Pubmed	Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	17898229
Pubmed	Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	21901321
Pubmed	Dopamine release in prefrontal cortex in response to beta-amyloid activation of alpha7 * nicotinic receptors.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	17935702
Pubmed	Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	20624304
Pubmed	Cytokine-induced alterations of α7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	21784975
Pubmed	Lack of acetylcholine nicotine alpha 7 receptor suppresses development of collagen-induced arthritis and adaptive immunity.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	20659128
Pubmed	Stimulation of α7 nicotinic acetylcholine receptor by nicotine increases suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	20843956
Pubmed	Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	10800961
Pubmed	BMP2-dependent gene regulatory network analysis reveals Klf4 as a novel transcription factor of osteoblast differentiation.	KLF4 BMP2	2.13e-05	2	161	2	33608506
Pubmed	Characterization of allelic variants at chromosome 15q14 in schizophrenia.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	16417613
Pubmed	Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	11834293
Pubmed	Reduced Chrna7 expression in mice is associated with decreases in hippocampal markers of inhibitory function: implications for neuropsychiatric diseases.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	22314319
Pubmed	Antagonism of Cerebral High Mobility Group Box 1 Ameliorates Dendritic Cell Dysfunction in Sepsis.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	34512319
Pubmed	Visual acuity is reduced in alpha 7 nicotinic receptor knockout mice.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	22281823
Pubmed	Activation of α7-nAChRs Promotes the Clearance of α-Synuclein and Protects Against Apoptotic Cell Death Induced by Exogenous α-Synuclein Fibrils.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	33718373
Pubmed	Nicotinic receptor involvement in regulation of functions of mouse neutrophils from inflammatory site.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	26965141
Pubmed	A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	27676657
Pubmed	Central role of alpha7 nicotinic receptor in differentiation of the stratified squamous epithelium.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	12391028
Pubmed	Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	25365546
Pubmed	α7 Nicotinic Acetylcholine Receptor Regulates the Function and Viability of L Cells.	CHRNA7 CHRFAM7A	2.13e-05	2	161	2	29992246
Cytoband	22q13.31-q13.33	L3MBTL2 TUBGCP6	1.22e-05	2	161	2	22q13.31-q13.33
GeneFamily	Zinc fingers C2H2-type\|Kruppel like factors	KLF8 KLF4 KLF7	1.46e-04	18	105	3	624
GeneFamily	Protein disulfide isomerases	PDIA3 PDIA4 TMX3	2.35e-04	21	105	3	692
GeneFamily	Cyclic nucleotide gated channels	HCN4 HCN1	1.46e-03	10	105	2	250
GeneFamily	Dyneins, cytoplasmic	DYNLL2 DYNLL1	2.50e-03	13	105	2	538
GeneFamily	SH2 domain containing	CHN2 SOCS7 TXK BTK	2.85e-03	101	105	4	741
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP42 STARD8 CHN2	3.06e-03	50	105	3	721
GeneFamily	Zinc fingers\|Zinc fingers PARP-type\|Poly(ADP-ribose) polymerases	ZFC3H1 PARP1	3.34e-03	15	105	2	26
GeneFamily	Zinc fingers\|Zinc fingers PARP-type\|Poly(ADP-ribose) polymerases	TIPARP PARP1	4.29e-03	17	105	2	684
GeneFamily	LIM domain containing	TES FHL2 PDLIM2	4.89e-03	59	105	3	1218
ToppCell	E15.5-Endothelial-large_vessel_endothelial_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	THSD7A KLF4 CD93 PTPRB ACKR3 ASS1 KDR FAM43A	3.40e-07	182	161	8	345d0f9d5ee30434bc2aac17608ccdc9e61c8fa3
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 HLA-DPA1 HLA-DQA2 KLF4 QSOX1 PTPRB ACKR3 FAM43A	5.31e-07	193	161	8	daefbfd3a3dd1351fbe94b9abfd807db44d56c24
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NUDT14 THSD7A ELMO1 CD93 KL PTPRB KDR CRYBG3	6.70e-07	199	161	8	b15304d3d3f6c254969b54a61bee3d9f368840b2
ToppCell	E16.5-samps-Endothelial-Immature_fetal_endothelial-Matrix_Endothelial\|E16.5-samps / Age Group, Lineage, Cell class and subclass	CD93 PTPRB CIAO3 ACKR3 GYS2 KDR FAM43A	1.51e-06	154	161	7	928f49839b046b90c2f942458f3e365ddc4e0bc9
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAN SLC43A3 KLF4 CD93 QSOX1 PTPRB ACKR3	2.69e-06	168	161	7	b6d948857ee652351ddbe383b75fdd1721cd8721
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAN SLC43A3 KLF4 CD93 QSOX1 PTPRB ACKR3	2.69e-06	168	161	7	3bddf411a60137a8883fc9e77586e4719b0d6067
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD7A JADE1 CD93 PTPRB BTD VWA3B FAM43A	2.91e-06	170	161	7	55fe16d98ea284d05fb899888e4569c685644c7b
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	COL3A1 GRIN2A SVEP1 SLIT2 PTPRB ACKR3 KDR	2.91e-06	170	161	7	7fa022471e14ac8a3bc147c793368a4d56a8e591
ToppCell	nucseq-Epithelial-Epithelial_Neuro-Secretory-PNEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	STXBP5L HCN1 ADCY2 TAGLN3 SYT4 RFPL3 NPAS4	3.02e-06	171	161	7	f4321133190a3df9d31f5d4021a464d3840145f1
ToppCell	nucseq-Epithelial-Epithelial_Neuro-Secretory-PNEC-PNEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	STXBP5L HCN1 ADCY2 TAGLN3 SYT4 RFPL3 NPAS4	3.02e-06	171	161	7	ed4fb6c84579d99df33de5f8f928c3cd2f3d3d72
ToppCell	E15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KLF4 CD93 PTPRB ACKR3 ASS1 KDR FAM43A	3.02e-06	171	161	7	3112d15f2a28cf4a71992db4971d960716dc1264
ToppCell	nucseq-Epithelial-Epithelial_Neuro-Secretory\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	STXBP5L HCN1 ADCY2 TAGLN3 SYT4 RFPL3 NPAS4	3.14e-06	172	161	7	d0cdedd734406988a9a93d7300c7b1a8b4b45c38
ToppCell	E17.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	THSD7A KLF4 CHN2 CD93 PTPRB ACKR3 FAM43A	3.94e-06	178	161	7	0139b42494c1186390b12106dea7957e2b6717c2
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Dendritic_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATR PPM1M PELI2 ACVR2B CHN2 SLIT2 PCNX4	4.24e-06	180	161	7	710526abedc8e0f9ba19ad69220df4c9468ada8f
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRF7 SLC43A3 KLF4 BMP2 PTPRB KLF7 KDR	4.56e-06	182	161	7	000ff26c51c6a1ea8770c02722523e55be83b46f
ToppCell	E16.5-samps-Endothelial-Immature_fetal_endothelial-Intermediate_Endothelial\|E16.5-samps / Age Group, Lineage, Cell class and subclass	SLC43A3 KLF4 CD93 PTPRB ZNF608 ACKR3 KDR	4.56e-06	182	161	7	fec1caf867b1dc87b24504d895ee1a27df78062e
ToppCell	facs-Liver-Liver_non-hepato/SCs_st\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRF7 SLC43A3 KLF4 BMP2 PTPRB KLF7 KDR	4.56e-06	182	161	7	b906e6e584ecbe92d3030bbdc4426f244fbe0045
ToppCell	10x5'-lymph-node_spleen-Myeloid_Dendritic-DC1\|lymph-node_spleen / Manually curated celltypes from each tissue	ZMYND15 STARD8 HLA-DPA1 HLA-DQA2 PLEKHG4B CD93 CRYBG3	4.72e-06	183	161	7	c9e3d91f4c3395a73295b92e25608e0effb5d241
ToppCell	tumor_Lung-Myeloid_cells-CD141+_DCs\|tumor_Lung / Location, Cell class and cell subclass	ZMYND15 HLA-DPA1 HLA-DQA2 PPM1M BTLA KLF4 PGLS	4.90e-06	184	161	7	f5cad8eb358898ae536cd7a7b37d3ce19528b801
ToppCell	Endothelial-E\|World / shred on cell class and cell subclass (v4)	THSD7A SLC43A3 CHN2 CD93 PTPRB ACKR3 ASS1	4.90e-06	184	161	7	b4c561924c508536fd2112e91e32176b95fdf63a
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THSD7A ELMO1 FAM221B CD93 PTPRB KDR FAM43A	5.07e-06	185	161	7	602536a3308a848f106adcb0a83530997440c8f4
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 STARD8 SLC43A3 CD93 BMP2 PTPRB ZNF608	5.26e-06	186	161	7	37860daeecd6d412bd3797f30496a56da667fbd1
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 STARD8 SLC43A3 CD93 BMP2 PTPRB ZNF608	5.26e-06	186	161	7	60830822d3de3147816693404fd03392e04c2b8e
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 STARD8 SLC43A3 CD93 BMP2 PTPRB ZNF608	5.26e-06	186	161	7	baebeffdd426ce767190ddefc857cc78e6a58d36
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	COL3A1 ARHGAP42 THSD7A GPC6 SVEP1 ELMO1 SLIT2	5.44e-06	187	161	7	a9316e2818217ec5feae9cf8816f7249803caee6
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STXBP5L CHD7 CHN2 SVEP1 SOCS7 TAGLN3 SYT4	5.44e-06	187	161	7	1b2fdbfb1ce3f19795dfc4b1da5a94f4b057ec41
ToppCell	P03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PIEZO1 SLC43A3 CHN2 CD93 PTPRB ACKR3 ASS1	5.64e-06	188	161	7	5eb107122064f0a99dfd445cc87d3766f7257216
ToppCell	P03-Endothelial-capillary_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SLC43A3 KLF4 CD93 PTPRB KLF7 ACKR3 KDR	5.64e-06	188	161	7	ede354ca550840d8f0c8dac22d8ce1f1d325886a
ToppCell	droplet-Kidney-nan-18m-Endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRF7 SLC43A3 KLF4 CD93 PTPRB KLF7 KDR	5.64e-06	188	161	7	ca3be1942b179b512ab242acded31f1e3748c753
ToppCell	P03-Endothelial\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SLC43A3 KLF4 CD93 PTPRB KLF7 ACKR3 KDR	5.64e-06	188	161	7	88d477aad98be124919b9c6b0b8dbd24e556422e
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 BCAT2 DAPK1 KL KCNQ1 INPP5J GOT1	5.84e-06	189	161	7	ff637ae0afdb1fdc67451be7e1e4fe575fbcfff4
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 BCAT2 DAPK1 KL KCNQ1 INPP5J GOT1	5.84e-06	189	161	7	e127e3be626bc513e151d41812f0b7adb89d5da6
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD7A KLF4 CD93 PTPRB ACKR3 KDR FAM43A	5.84e-06	189	161	7	feedac2751ed770f80bc56fec31662b5b3826f58
ToppCell	P07-Endothelial\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SLC43A3 KLF4 CD93 PTPRB KLF7 ACKR3 KDR	5.84e-06	189	161	7	d62b5b5c3cd259befa7afb19f45e3804e2ab80f7
ToppCell	P07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	THSD7A SLC43A3 KLF4 CHN2 PTPRB ACKR3 ASS1	6.04e-06	190	161	7	e1b721bb74561fe51c53328a0394c9954e489049
ToppCell	PND01-Endothelial-Endothelial_blood-vessel\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC43A3 KLF4 CD93 PTPRB KLF7 ACKR3 KDR	6.04e-06	190	161	7	2803eb02209591a63fe13e834e4e0f8014e1aa34
ToppCell	PND01-Endothelial\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC43A3 KLF4 CD93 PTPRB KLF7 ACKR3 KDR	6.25e-06	191	161	7	96b9b0aaf0cb2d6f929ff563dbaedc83ffb4795e
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD7A SLC43A3 CHN2 CD93 PTPRB ACKR3 ASS1	6.25e-06	191	161	7	54bbccc554f43ba2ebdf9ea191b94c8f16081b53
ToppCell	P03-Endothelial-large_vessel_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	THSD7A SLC43A3 KLF4 CD93 PTPRB ACKR3 ASS1	6.25e-06	191	161	7	b680e0c35f1004be36f9f0680ae3c62952e2b607
ToppCell	droplet-Kidney-KIDNEY-1m-Endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRF7 SLC43A3 KLF4 CD93 PTPRB KLF7 KDR	6.25e-06	191	161	7	767269dbd799e08c4ebba13e8c968fb148acf182
ToppCell	P07-Endothelial-large_vessel_endothelial_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	THSD7A SLC43A3 KLF4 CD93 PTPRB ACKR3 ASS1	6.25e-06	191	161	7	d162917816dd2e4767c97447c1cddae9397713ab
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD7A SLC43A3 CHN2 CD93 PTPRB ACKR3 ASS1	6.25e-06	191	161	7	0e8a73f01e3ec95d242c09231bcf3790324d0a67
ToppCell	facs-Lung-Endomucin_-18m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 KLF4 CD93 QSOX1 PTPRB KLF7 KDR	6.47e-06	192	161	7	ba3fe97786564dba1c8185f2802ce1b57f4f3cc9
ToppCell	facs-Lung-Endomucin_\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 KLF4 CD93 QSOX1 PTPRB KLF7 KDR	6.47e-06	192	161	7	85d4d0df701451daf95e94a87a0096da1e86533b
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 CD93 BMP2 PTPRB KLF7 KDR FAM43A	6.47e-06	192	161	7	5890076929598e88fe9d59a4e4e858b446746ce9
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD8 SLC43A3 CD93 BMP2 PTPRB KLF7 KDR	6.47e-06	192	161	7	d525f7f088a53110912600a7c9f6d33b9270d534
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC43A3 KLF4 CHN2 CD93 PTPRB ACKR3 ASS1	6.47e-06	192	161	7	cd4c9b9ab17a779c154264f7459020f51e528ba5
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD8 SLC43A3 CD93 BMP2 PTPRB KLF7 KDR	6.47e-06	192	161	7	2bfac6b3956265205ca47d06888851ed68b65999
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	STARD8 SLC43A3 KLF4 MAP3K6 CD93 KLF7 KDR	6.69e-06	193	161	7	b6b065b0c2ad31d1488dfa970450b29a8ac1f3aa
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 CD93 BMP2 PTPRB KLF7 KDR FAM43A	6.69e-06	193	161	7	d5f6d6e2c36d4e80af4d39cdfc0b18df295a587b
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	STARD8 SLC43A3 KLF4 MAP3K6 CD93 KLF7 KDR	6.69e-06	193	161	7	4513e6cb3f86d9cc56e7892fbe11a861335bd179
ToppCell	P15-Endothelial-large_vessel_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	THSD7A CHN2 CD93 QSOX1 PTPRB ACKR3 ASS1	6.69e-06	193	161	7	5f9a7cd5f8eb9ac294cdb50518fedf872f3f78f5
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD7A SLC43A3 KLF4 CD93 PTPRB ACKR3 ASS1	6.69e-06	193	161	7	58c590dd6f21bc7ae58ae1729dd574c0f1069592
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 KLF4 CD93 QSOX1 PTPRB KLF7 KDR	6.69e-06	193	161	7	2218833749576ba1a0fc95bd155c781e7e1163c6
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 CD93 BMP2 PTPRB KLF7 KDR FAM43A	6.69e-06	193	161	7	4a8c97ff2dffc5c06351d1cb107e21e58250aa55
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 BCAT2 DAPK1 SLIT2 KCNQ1 INPP5J GOT1	6.69e-06	193	161	7	b397c14ac1e34c6be3f25d4417d200bc518d3048
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 BCAT2 DAPK1 SLIT2 KCNQ1 INPP5J GOT1	6.69e-06	193	161	7	241a60d1f0d5832638fb3e1e4b7afa7387ea3c75
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 BCAT2 DAPK1 KL KCNQ1 INPP5J GOT1	6.69e-06	193	161	7	fa8bcf2a5ab7b08fae98a1466a936995142b4309
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD8 SLC43A3 CD93 BMP2 PTPRB KLF7 KDR	6.92e-06	194	161	7	c8b9551b93a5aed62154b487db90130604a6125c
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	COL3A1 THSD7A DAPK1 GPC6 ADCY2 SVEP1 SLIT2	6.92e-06	194	161	7	99577a5a631e607b5abe7a1b0d8d6a5eabe50196
ToppCell	facs-Lung-Endomucin_-18m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 KLF4 CD93 QSOX1 PTPRB KLF7 KDR	6.92e-06	194	161	7	df56e23f1dcf1902d29392fcc947e0e268e1648b
ToppCell	PBMC-Severe-Lymphocyte-B\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ARHGAP42 HLA-DPA1 HLA-DQA2 BTLA PDIA4 PARP1 BTK	6.92e-06	194	161	7	bd2c53fb064edfec76abe56a9ffaced0bda32ab0
ToppCell	PBMC-Severe-Lymphocyte-B\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ARHGAP42 HLA-DPA1 HLA-DQA2 BTLA PDIA4 PARP1 BTK	6.92e-06	194	161	7	7dbedbdece4271e10134c9338c85cb3e04484c75
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	STARD8 SLC43A3 KLF4 CD93 PTPRB KLF7 KDR	6.92e-06	194	161	7	c6cee7d15af76f9a60d7f414ef0bcc1735c47b7a
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	STARD8 SLC43A3 KLF4 CD93 PTPRB KLF7 KDR	7.16e-06	195	161	7	d700e959e060932e3854a9cf294799465efbe18b
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	COL3A1 THSD7A DAPK1 GPC6 ADCY2 SVEP1 SLIT2	7.16e-06	195	161	7	70387a62f121f8c374dba1aca9ab65cfed6a0b10
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD8 SLC43A3 CD93 BMP2 PTPRB KLF7 KDR	7.16e-06	195	161	7	12ba6d95e42d06b1991b011043c0e3370a7b4131
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARHGAP42 THSD7A PRSS22 DAPK1 SOCS7 PLEKHG4B ZNF608	7.16e-06	195	161	7	dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCell	ILEUM-inflamed-(7)_Endothelial_cell-(7)_CD36+_endothelial_cells\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	MAP3K6 PTPRB EEPD1 ASS1 DYNLL1 KDR CRYBG3	7.65e-06	197	161	7	66339b5aae3952f5c484c9dcb0cfb4fbd828d4cb
ToppCell	(4)_Blood_vessel\|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	THSD7A HLA-DPA1 BCAT2 CD93 PTPRB DYNLL1 KDR	7.65e-06	197	161	7	1b82979a41ef46c814c82527a585900586d71260
ToppCell	(4)_Endothelial_cells\|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	THSD7A HLA-DPA1 BCAT2 CD93 PTPRB DYNLL1 KDR	7.65e-06	197	161	7	dd9abb43c23e7698433e455eacbf5b23b0a756c2
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL3A1 GPC6 SVEP1 QSOX1 SLIT2 CRYBG3 FHL2	7.91e-06	198	161	7	0f4052a59c6bd89dab637d6ef1214460d6cbcf55
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-B\|COVID-19_Severe / Disease, condition lineage and cell class	ARHGAP42 HLA-DPA1 HLA-DQA2 BTLA PDIA4 PARP1 BTK	7.91e-06	198	161	7	1831a777dd996c25f637d551d754ec1b9c23feb2
ToppCell	Transplant_Alveoli_and_parenchyma-Mesenchymal-Fibroblasts\|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X	COL3A1 KLF4 PDIA3 SVEP1 QSOX1 SLIT2 ACKR3	8.17e-06	199	161	7	f19c683f38bca3bfee40396f27423441051dec67
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HLA-DPA1 KLF4 MAP3K6 CD93 PTPRB KLF7 KDR	8.17e-06	199	161	7	e6715288a586631676722f2323f0d833431161cf
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ARHGAP42 THSD7A HLA-DPA1 CHRNA7 ZNF608 CHRFAM7A HCRTR1	8.45e-06	200	161	7	53d5e427f0cbf5cf0b63efe4ec01da302f555704
ToppCell	kidney_cells-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HLA-DPA1 KLF4 MAP3K6 CD93 PTPRB KLF7 KDR	8.45e-06	200	161	7	9f1626a7e1bd00977a5c316cafbdf654b52bad94
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HLA-DPA1 KLF4 MAP3K6 CD93 PTPRB KLF7 KDR	8.45e-06	200	161	7	3007583eaad3a5ae2df010513d3e4df59155123d
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Neuronal\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	TMEM169 THSD7A KLF7 PTPRO TAGLN3 SYT4 ZNF766	8.45e-06	200	161	7	04699d1149a143b96d6f292c0d70c4d3e6dfc611
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	H1-9P KLF4 QSOX1 BMP2 SYT4 KDR	1.66e-05	148	161	6	941bad657064b3d37cae8b66df99c1aa1098c088
ToppCell	frontal_cortex\|World / Per Region, Lineage, Cell class, Cell type, Cell subtype	PRSS22 GPC6 BMP2 PTPRO ASS1 VWA3B	1.93e-05	152	161	6	f9c29d4568402ca07a717dbffb3ccc7f35c5fe56
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 GRIN2A SVEP1 EEPD1 FHL2 IMPG2	2.76e-05	162	161	6	bfaeff19bb56598fdc8c82be71d51787cf13928f
ToppCell	facs-Trachea-3m-Hematologic-myeloid-granulocyte-granulocyte_l26\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KLF8 JMJD4 CHN2 RPUSD4 PTPN7 CIAO3	3.06e-05	165	161	6	23955e3373660f827518e723ac62fba99753f375
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD7A SLC43A3 KLF4 CD93 PTPRB IMPG2	3.16e-05	166	161	6	7a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCell	normal_Lung-Myeloid_cells-CD163+CD14+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	RALGDS HLA-DPA1 HLA-DQA2 TIPARP GYS2 C18orf63	3.16e-05	166	161	6	07b498eb341abec02a3ccaae320bdbb5cd6883c5
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD7A SLC43A3 KLF4 CD93 PTPRB IMPG2	3.16e-05	166	161	6	bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCell	facs-Kidney\|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAS2 LDHD KL SLC17A1 ASS1 KDR	3.38e-05	168	161	6	d2f17a470e04f8f0edb111894027bcfc6ee1a12f
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD7A SLC43A3 KLF4 KL PTPRB ACKR3	3.50e-05	169	161	6	04c6ed38e1d1befba5ef5f37a3c1e045a0b163d6
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD7A SLC43A3 KLF4 KL PTPRB ACKR3	3.50e-05	169	161	6	58136b8a0bf2dab45c91a053ef7225ea49ccb871
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination__)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZMYND15 SETD4 TIPARP LDHD PCNX4 EEPD1	3.74e-05	171	161	6	d1e87478d8c0329e662849823f5c7604f20e1b1a
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CHD7 JADE1 FBXO46 PTPRB ACKR3 PLD1	3.86e-05	172	161	6	8a6a2b4c6654bc976e60a02d0e7303a9071ed55f
ToppCell	droplet-Liver-Npc-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 CD93 BMP2 PTPRB KLF7 KDR	3.86e-05	172	161	6	a6fb1bde8d942c7b5caaf7bd14de0b7ce32fda55
ToppCell	ILEUM-inflamed-(1)_T_cell-(1)_T_(gd)\|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ARHGAP42 ZAN HCN1 CHN2 TXK CKMT2	3.99e-05	173	161	6	62f2f42f54c9c6941bf888956be40230f92c883e
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Egln3_(Cortical_subplate_interneuron)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ZAN ABCA13 C7orf57 RTL1	4.03e-05	53	161	4	5fa009c9f30c77de6cece40a47da46241f1de54c
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Egln3_(Cortical_subplate_interneuron)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ZAN ABCA13 C7orf57 RTL1	4.03e-05	53	161	4	52a1f2a041e3ba2b11ed753f2f57b78e68b5cc0c
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARHGAP42 THSD7A CHD7 CHRNA7 ZNF608 CHRFAM7A	4.12e-05	174	161	6	fdadac1eaab2c4a67e4832f0901df22e893add6a
ToppCell	10x5'-blood-Myeloid_Dendritic\|blood / Manually curated celltypes from each tissue	HLA-DPA1 HLA-DQA2 IRF7 KLF4 FAM221B PLEKHG4B	4.25e-05	175	161	6	1c48eec300d5a6d4a810947b995af3b8c0a5a601
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 PIEZO1 QSOX1 PTPRB KLF7 TRPV2	4.25e-05	175	161	6	90302e8a44858ef3b2a165b88284d4788d591a99
ToppCell	facs-Lung-Endomucin-24m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 KLF4 CD93 PTPRB KLF7 KDR	4.25e-05	175	161	6	eedb33e3e350169d1d37f2ac9939dcf704e7b696
ToppCell	Thalamus-Neuronal-Excitatory\|Thalamus / BrainAtlas - Mouse McCarroll V32	TMEM169 THSD7A HCN4 GRIN2A ADAM11 HERC1	4.39e-05	176	161	6	d2bbf13d21fb7582d7e5f90cd61a4ebe1cfccd66
Disease	thyroid gland carcinoma (is_marker_for)	CD93 PTPRB KDR	2.85e-05	12	152	3	DOID:3963 (is_marker_for)
Disease	Colorectal Carcinoma	COL3A1 RALGDS STARD8 ABCA13 SETD4 GRIN2A CD93 BMP2 PARP1 KL ACKR3 KDR PMM2	7.44e-05	702	152	13	C0009402
Disease	breast angiosarcoma (is_implicated_in)	PTPRB KDR	7.88e-05	3	152	2	DOID:4511 (is_implicated_in)
Disease	sick sinus syndrome (implicated_via_orthology)	HCN4 HCN1	7.88e-05	3	152	2	DOID:13884 (implicated_via_orthology)
Disease	Colorectal Neoplasms	STARD8 ABCA13 GRIN2A BMP2 PARP1 ACKR3 KDR PMM2	9.96e-05	277	152	8	C0009404
Disease	QRS duration	ARHGAP42 USP34 HCN1 KLF7 BTD KCNQ1 FHL2 ANAPC7	1.64e-04	298	152	8	EFO_0005055
Disease	diastolic blood pressure, systolic blood pressure	HCN4 HLA-DPA1 HCN1 GPC6 QSOX1 KLF7 ASB3 SYT4 DYNLL1 VWA3B PLD1 FHL2	1.93e-04	670	152	12	EFO_0006335, EFO_0006336
Disease	brain glioma (is_marker_for)	PTPRB KDR	2.61e-04	5	152	2	DOID:0060108 (is_marker_for)
Disease	cognitive disorder (implicated_via_orthology)	CHRNA7 CHRFAM7A	3.90e-04	6	152	2	DOID:1561 (implicated_via_orthology)
Disease	rheumatoid arthritis (biomarker_via_orthology)	CHRNA7 CHRFAM7A	3.90e-04	6	152	2	DOID:7148 (biomarker_via_orthology)
Disease	pappalysin-1 measurement	USP34 CHD7	3.90e-04	6	152	2	EFO_0802845
Disease	electrocardiography	COL3A1 ARHGAP42 MBOAT1 HCN4 HLA-DPA1 HCN1 ADAM11 ZFC3H1 BTD KCNQ1	4.43e-04	530	152	10	EFO_0004327
Disease	Depression, Bipolar	THSD7A GRIN2A ADCY2 NPAS4	7.53e-04	79	152	4	C0005587
Disease	age at onset, coronary stenosis	DYNLL1 PLD1	9.27e-04	9	152	2	EFO_0004847, MONDO_0006715
Disease	Marfan syndrome (implicated_via_orthology)	ACVR2B BMP2	1.15e-03	10	152	2	DOID:14323 (implicated_via_orthology)
Disease	2-ketocaprylate measurement	LDHD PCNX4	1.15e-03	10	152	2	EFO_0800110
Disease	Ashkenazi Jewish disorders	HEXA MCOLN1	1.41e-03	11	152	2	cv:CN118946
Disease	chronic kidney disease	THSD7A HCN1 GAS2 GRIN2A PARP1 KCNQ1	1.41e-03	235	152	6	EFO_0003884
Disease	nasopharynx carcinoma (is_marker_for)	ATR GRIN2A KDR	1.42e-03	43	152	3	DOID:9261 (is_marker_for)
Disease	S-warfarin to R-warfarin ratio measurement	GPC6 ELMO1 DYNLL1 HCRTR1	1.50e-03	95	152	4	EFO_0803331
Disease	nicotine dependence (implicated_via_orthology)	CHRNA7 CHRFAM7A	1.68e-03	12	152	2	DOID:0050742 (implicated_via_orthology)
Disease	N-acetyl-2-aminooctanoate measurement	LDHD BTD	1.68e-03	12	152	2	EFO_0800567
Disease	temporal pole volume measurement	PTPRO SYT4	1.68e-03	12	152	2	EFO_0010334
Disease	Hereditary hemochromatosis	AKR1D1 BMP2	1.68e-03	12	152	2	C0392514
Disease	Hemochromatosis	AKR1D1 BMP2	1.68e-03	12	152	2	C0018995
Disease	cardiomyopathy (biomarker_via_orthology)	UTS2R GOT1	1.98e-03	13	152	2	DOID:0050700 (biomarker_via_orthology)
Disease	juvenile polyposis syndrome (implicated_via_orthology)	ACVR2B BMP2	1.98e-03	13	152	2	DOID:0050787 (implicated_via_orthology)
Disease	response to bronchodilator, FEV/FEC ratio	COL3A1 THSD7A SPTSSB HCN1 PELI2 DAPK1 GPC6 PARP1 ACKR3 ASB3 DYNLL1	2.13e-03	766	152	11	EFO_0004713, GO_0097366
Disease	facial width measurement	DAPK1 GRIN2A DISP1 RFPL3	2.16e-03	105	152	4	EFO_0007855
Disease	inositol measurement	TAGLN3 SYT4	2.30e-03	14	152	2	EFO_0010504
Disease	Liver Cirrhosis, Experimental	COL3A1 TES MAGEE1 TIAL1 SLC17A1 PTPRO ACKR3 FHL2 ABCG5 GOT1 FAM43A	2.31e-03	774	152	11	C0023893
Disease	mental or behavioural disorder	DAPK1 PHF8 GPC6 HACE1 TMX3	2.40e-03	179	152	5	EFO_0000677
Disease	severe aplastic anemia	HLA-DPA1 HLA-DQA2	2.65e-03	15	152	2	EFO_0006927
Disease	quinate measurement	EEPD1 KCNQ1	2.65e-03	15	152	2	EFO_0021167
Disease	response to reverse transcriptase inhibitor, HIV-1 infection, peripheral neuropathy	STXBP5L GPC6 PTPRB	2.74e-03	54	152	3	EFO_0000180, EFO_0003100, GO_0061479
Disease	Withdrawal Symptoms	GRIN2A CHRNA7 HCRTR1	3.36e-03	58	152	3	C0087169
Disease	Drug Withdrawal Symptoms	GRIN2A CHRNA7 HCRTR1	3.36e-03	58	152	3	C0086189
Disease	Substance Withdrawal Syndrome	GRIN2A CHRNA7 HCRTR1	3.36e-03	58	152	3	C0038587
Disease	Uremia	BMP2 KDR	3.41e-03	17	152	2	C0041948
Disease	Hemangiosarcoma	PTPRB KDR	3.82e-03	18	152	2	C0018923
Disease	Post-Traumatic Osteoporosis	GPC6 KL PGLS	3.88e-03	61	152	3	C0751406
Disease	Osteoporosis, Senile	GPC6 KL PGLS	3.88e-03	61	152	3	C0029459
Disease	Osteoporosis, Age-Related	GPC6 KL PGLS	3.88e-03	61	152	3	C0001787
Disease	Osteoporosis	GPC6 KL PGLS	4.25e-03	63	152	3	C0029456
Disease	Phenyllactate (PLA) measurement	DAPK1 SLC17A1	4.26e-03	19	152	2	EFO_0021662
Disease	hepatitis B virus infection	HLA-DPA1 GRIN2A	4.26e-03	19	152	2	EFO_0004197
Disease	Omenn Syndrome	CHD7 DCLRE1C	4.26e-03	19	152	2	C2700553
Disease	response to methotrexate, neurotoxicity	MBOAT1 GPC6	4.26e-03	19	152	2	EFO_0011057, GO_0031427
Disease	hypertension (implicated_via_orthology)	UTS2R KL KCNQ1 DYNLL1	4.41e-03	128	152	4	DOID:10763 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KEEETPLHCAAWHGY	DAPK1	476	P53355
APDKHEYCIWTDGLN	ELMO1	656	Q92556
WILYEKPHFRGQKCV	CRYBG3	2336	Q68DQ2
WCTELERIFGFPVHY	DNMT3B	801	Q9UBC3
PHTGKLCWFLDEAAA	PGLS	231	O95336
SDLVQKYHPCFWIDG	BTK	136	Q06187
YSCWHEKADERPTFK	BTK	631	Q06187
PYLDIWNIHGKESCD	BTLA	21	Q7Z6A9
SPCFKEHEYTEFGKW	ALLC	31	Q8N6M5
DIFYCGKLWATNHVP	AKR1D1	81	P51857
KGDLWEACSVGIPYH	GYS2	131	P54840
EWNSKYRPVCIHLAG	ABHD18	101	Q0P651
VLWGHAAADRFCYEK	ADAM11	556	O75078
HYFLCKEKAPDVFDW	CD93	236	Q9NPY3
PSAEDFYDCRVEHWG	HLA-DPA1	186	P20036
NLLEYHVPKRWGCLA	ABCA13	4986	Q86UQ4
CKRHPLYVDFSDVGW	BMP2	296	P12643
DRGEPVTHYLVKWCS	CHD7	896	Q9P2D1
VLCDVWNYTKFDKPH	DISP1	576	Q96F81
HCPVLAEFYTEKDWS	EEPD1	531	Q7L9B9
VYTGFWHSPECEFVR	ASS1	321	P00966
YIDVRWFPFDVQHCK	CHRNA7	151	P36544
FRQYWDIPDGTDCHR	NDUFA11	6	Q86Y39
GHCIAFAPTWKALAE	QSOX1	71	O00391
QLREGKEKCVHYWPT	PTPN7	196	P35236
RWYHPGCFVKNREEL	PARP1	156	P09874
CRDHFGWREYPESVI	TIPARP	351	Q7Z3E1
KGWYEKCEPGSSREH	KRT26	116	Q7Z3Y9
FCGWIVLGPYHVKFR	MCOLN1	441	Q9GZU1
EPWVVSGCHSFYSKR	ANAPC7	306	Q9UJX3
RLYFHLGIWPEKSFC	FBXO21	431	O94952
PSADEIYDCKVEHWG	HLA-DQA2	181	P01906
EKGRVKCDHYWPADQ	PTPRB	1806	P23467
LRTHTGEKPYHCDWD	KLF4	451	O43474
RPTGWKCFVYHFAVF	KCNQ1	116	P51787
YEFLWGPRAHAETSK	MAGEB3	271	O15480
CKPVEYEFFWGPRSH	MAGEE1	646	Q9HCI5
LVWDHSYKVGCAVTP	GLIPR1L2	161	Q4G1C9
KEAWEECGYHLAPSD	NUDT14	121	O95848
SCFKHVPLYDQWEDV	L3MBTL2	196	Q969R5
VKHLCGDWFPIEYPD	NAA60	26	Q9H7X0
SRPEDWHLGGKCDVY	HERC1	3986	Q15751
PIGWHCLDDKNSFYV	RABIF	101	P47224
PIIDSEVCSHLYWRG	PRSS22	201	Q9GZN4
FDKKYNPTWHCIVGR	DYNLL1	46	P63167
WYRKAFDVEPSLHSG	MAP3K6	381	O95382
GPEKHFSWKECLFYI	PCNX4	346	Q63HM2
RYEKGDVSLCRWHPK	FBXO46	536	Q6PJ61
KYEFPDKDWAHISCA	MKNK2	326	Q9HBH9
PHYLWDCFRIGDESR	FAM221B	256	A6H8Z2
AQPFKDRCEWFYEHL	HACE1	521	Q8IYU2
RIHTGEKPYKCTWDG	KLF8	296	O95600
EEGIYWRYCDIPSCH	KREMEN2	106	Q8NCW0
KTSCEPYTRFIHDWV	TUBGCP6	526	Q96RT7
RTHTGEKPYKCSWEG	KLF7	241	O75840
ADPHKVYALSRELCW	IRF7	116	Q92985
DFDGRPCIVCPWHKY	RFESD	71	Q8TAC1
YIDVRWFPFDVQHCK	CHRFAM7A	61	Q494W8
RVKSAGFWIIHPYSD	HCN4	246	Q9Y3Q4
EKRRVKCDHYWPFTE	PTPRO	1041	Q16827
YREWSTFAVGPGHCL	NEU2	151	Q9Y3R4
LCKSWYGLLHPEDLA	NPAS4	246	Q8IUM7
SWLFGHALCKVIPYL	HCRTR1	111	O43613
NFKVHTFRGPHWCEY	CHN2	216	P52757
RYLESWGAAKPFAHL	ADCY2	496	Q08462
RKGCSLGPWNHIYEF	ASB3	366	Q9Y575
LPWIYSHSDDGCLKL	ATR	596	Q13535
CLPEWEDGHFYLAKY	ATR	2031	Q13535
RVKTAGFWIIHPYSD	HCN1	126	O60741
ECWNGHSKARYLPEI	GPC6	421	Q9Y625
CRHPKAEEYFQWSKL	DCLRE1C	256	Q96SD1
KELQGATHRYAPCDW	C7orf57	6	Q8NEG2
SWEKPCDHGSEILAY	FNDC3A	881	Q9Y2H6
YLKDWHLCRDFPVED	JMJD4	181	Q9H9V9
HNAWYAALATRPGCK	LDHD	371	Q86WU2
CRSFYPEHSIKEWLI	ACKR3	196	P25106
CYWTLGLHPEVARFG	ABCG5	486	Q9H222
LGVGAYRTDDCHPWV	GOT1	36	P17174
VPVWGKEGYLHVCSN	BTD	406	P43251
TGGVTYREQPWHKEC	FHL2	171	Q14192
TYCVADARLPKVFAW	FAM43A	141	Q8N2R8
VPYHCLGSIWSQRDK	RALGDS	406	Q12967
WFVHKASFPARLCYL	MBOAT1	271	Q6ZNC8
ELCFRHFGGQVKYWI	KL	221	Q9UEF7
KFCHPELKSGEYWVD	COL3A1	1266	P02461
AVELKYCHGWRPAGQ	H1-9P	81	P60008
KRGCEQVLWLYGPDH	BCAT2	246	O15382
TPTHDEKGEERYICW	PRDM13	126	Q9H4Q3
EEEHVERFRYGWCKS	PROCA1	136	Q8NCQ7
RHWDALYGYKLPGDC	C18orf63	231	Q68DL7
FDKKYNPTWHCIVGR	DYNLL2	46	Q96FJ2
KDCGDLEPRYTVWVH	OTOGL	151	Q3ZCN5
PDARGIWHNYDKTFL	CKMT2	246	P17540
YLHLGGDEVDFTCWK	HEXA	316	P06865
DVFPDGWDKRYCLRH	PMM2	181	O15305
WETFAGYLLKHDPCR	GAS2	256	O43903
CPILGDHKYSDWNRL	RPUSD4	281	Q96CM3
VHAPEVDWIKGRCTF	RTL1	511	A6NKG5
GGEHWKEICDYPRRQ	SYT4	401	Q9H2B2
GSPRFTCGRHYWEVD	RFPL1	171	O75677
LGSPCFIAGRHYWEV	TRIM27	361	P14373
PCLVFHEGGYWRELT	TRMT2B	216	Q96GJ1
YAERAGYDKLWHPAC	TES	251	Q9UGI8
CEAEELRYSLHVGPW	THSD7A	246	Q9UPZ6
DGCYRGEPSWFHRKA	TAGLN3	141	Q9UI15
YREVGDFDKIWREHC	BMT2	51	Q1RMZ1
ELHGETRFWHGKDYC	PLD1	636	Q13393
EKRPLGFTWIKHYCT	ARHGAP42	276	A6NI28
VVEEKQPWAYLSCGH	PELI2	301	Q9HAT8
DVLIEFYAPWCGHCK	PDIA3	396	P30101
EHADGKRYFTWDPSR	GANAB	431	Q14697
FEKEWIECAHGIGYT	NDUFS5	36	O43920
WFVLFYDDPKDHPCI	SLC17A1	216	Q14916
RWRKHEEVFICYGPH	SETD4	261	Q9NVD3
FHPFLVYRECRTWKE	SLC43A3	471	Q8NBI5
HIRLAWEFFSKICGY	SPTSSB	56	Q8NFR3
IILVEFYAPWCGHCK	PDIA4	196	P13667
RRFGWDCHGLPVEYE	IARS1	81	P41252
VPNARWFDYHTGKDI	SI	1651	P14410
WYRGKHCEEFVSEPV	IMPG2	1086	Q9BZV3
HQACYGILKVPEGSW	JADE1	231	Q6IE81
YWDHLEFCDGFRKLL	SPG21	81	Q9NZD8
ESGEWNHLIPYCKAV	SVEP1	1831	Q4LDE5
FWVGDELYCEKHARQ	PDLIM2	326	Q96JY6
GRSPDWYNKVFGHLC	STARD8	986	Q92502
CHLPFQSKWLYVGTE	STXBP5L	161	Q9Y2K9
RGLSYLHEDVPWCRG	ACVR2B	296	Q13705
PGWICYAEKTHGSFI	CIAO3	191	Q9H6Q4
DWIGLYRVGFRHCKD	INPP5J	771	Q15735
VDFYAPWCGHCKKLE	TMX3	46	Q96JJ7
GLEWPVREGCHQYSL	ZDHHC6	286	Q9H6R6
LYHCSIGRSLPEAEW	ZFHX2	736	Q9C0A1
PYSHGDWICFRQRLE	PLEKHG4B	336	Q96PX9
EWLTLCPEEFLTGHY	PPM1M	106	Q96MI6
CDRTFVWPAHFKYHL	ZNF410	226	Q86VK4
VDVWEFLGKPKHCQY	TDP2	281	O95551
LSHLSRKFTEWCYGP	TRPV2	321	Q9Y5S1
PFICDCHLKWLADYL	SLIT2	431	O94813
GSPRFTCGRHYWEVD	RFPL3	171	O75679
AVGYHLEWFIRGKDP	SMIM12	26	Q96EX1
HYRGTFSLWCHPKFE	SOCS7	451	O14512
YEVMYSCWHEKPEGR	TXK	496	P42681
YVTKEWHFGDVGCRV	UTS2R	111	Q9UKP6
YVGTLLDCTKHDWAP	ZNF608	401	Q9ULD9
GLCHSWFPERDEYVA	ZNF687	966	Q8N1G0
RFPNFETICWYVGKH	PHF8	396	Q9UPP1
HCERLPYDASKWEFP	KDR	816	P35968
LCYGLWDHEEDSPSK	PIEZO1	1801	Q92508
AEHWRIRTGEKPYKC	ZNF766	231	Q5HY98
YWPHEDVRAECRFVG	USP34	1881	Q70CQ2
AKYCSRFVHAPWKDG	VWA3B	446	Q502W6
GRYVAVPACEHVFIW	WDR3	36	Q9UNX4
EERTFWHKISYCPCL	TMEM169	196	Q96HH4
HWRVHTGERPYKCSD	ZNF419	361	Q96HQ0
FQGKLYPILDTCWHE	TRIM50	446	Q86XT4
EGHVVKCYWGKESPD	TIAL1	266	Q01085
GTKDLAPWAYALLCH	ZMYND15	236	Q9H091
PEIWCHYLRLFSKRG	ZFC3H1	1401	O60293
EEHLWECKQLGVYSP	ZMYM3	1191	Q14202
RKPSVHWSDAAEYFC	TRAV8-3	96	A0A0A6YYJ7
VNIFWKHLPSECYDK	TYW5	246	A2RUC4
CLHPAGSYFKVGERW	ZAN	1481	Q9Y493
SRHWRIHTGEKPYEC	ZNF302	296	Q9NR11
RHAVWPRYKSFSDCE	GRIN2A	386	Q12879