Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	6.39e-07	5	81	3	GO:0030156
GeneOntologyMolecularFunction	helicase activity	DHX37 MCM7 CHD2 CHD4 RAD54L2 DDX41	4.44e-05	158	81	6	GO:0004386
GeneOntologyMolecularFunction	calcium-induced calcium release activity	PKD2 RYR3	2.41e-04	6	81	2	GO:0048763
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	CHD2 CHD4 RAD54L2	4.52e-04	37	81	3	GO:0140658
GeneOntologyCellularComponent	manchette	RIMBP3 RIMBP3C RIMBP3B	1.65e-04	28	80	3	GO:0002177
GeneOntologyCellularComponent	fibrillar center	EEF1D DEAF1 GON4L CC2D1A STOX1	3.33e-04	156	80	5	GO:0001650
MousePheno	abnormal placenta size	FOCAD GHR RTL1 PEG10 PIEZO1 RAPGEF2 NOTCH2	4.34e-06	141	66	7	MP:0004258
MousePheno	abnormal placenta morphology	FOCAD GHR EEF1D CACNA2D2 RTL1 PEG10 PIEZO1 PKD2 STOX1 RAD54L2 RAPGEF2 NOTCH2	5.37e-06	525	66	12	MP:0001711
MousePheno	abnormal learning/memory/conditioning	FOCAD GHR CAPN12 KSR1 EEF1D ABCA2 FBXO9 ANK2 TBC1D30 PPP1R14C ZDHHC5 ZFYVE19 PLCD4 JAKMIP1 RAPGEF2 VAMP4 ZDHHC8 RYR3	1.12e-05	1239	66	18	MP:0002063
MousePheno	abnormal cognition	FOCAD GHR CAPN12 KSR1 EEF1D ABCA2 FBXO9 ANK2 TBC1D30 PPP1R14C ZDHHC5 ZFYVE19 PLCD4 JAKMIP1 RAPGEF2 VAMP4 ZDHHC8 RYR3	1.21e-05	1246	66	18	MP:0014114
MousePheno	neonatal lethality, incomplete penetrance	DEAF1 ANK2 RTL1 SYNE1 CC2D1A CHD4 F5 NOTCH2	7.62e-05	298	66	8	MP:0011088
MousePheno	ectopic manchette	RIMBP3 RIMBP3C RIMBP3B	9.23e-05	19	66	3	MP:0009377
MousePheno	detached sperm flagellum	RIMBP3 RIMBP3C RIMBP3B	1.26e-04	21	66	3	MP:0008893
Domain	DUF4939	RTL1 RTL5 PEG10	8.56e-06	10	79	3	PF16297
Domain	DUF4939	RTL1 RTL5 PEG10	8.56e-06	10	79	3	IPR032549
Domain	LDOC1-rel	RTL1 RTL5 PEG10	1.17e-05	11	79	3	IPR032567
Domain	Peptidase_aspartic_dom	RTL1 PEG10 ASPRV1	4.75e-05	17	79	3	IPR021109
Domain	JAKMIP_CC3	JAKMIP1 JAKMIP2	5.29e-05	3	79	2	PF16034
Domain	JAKMIP	JAKMIP1 JAKMIP2	5.29e-05	3	79	2	IPR024836
Domain	JAKMIP_C	JAKMIP1 JAKMIP2	5.29e-05	3	79	2	IPR031994
Domain	Helicase_C	DHX37 CHD2 CHD4 RAD54L2 DDX41	9.04e-05	107	79	5	PF00271
Domain	HELICc	DHX37 CHD2 CHD4 RAD54L2 DDX41	9.04e-05	107	79	5	SM00490
Domain	Helicase_C	DHX37 CHD2 CHD4 RAD54L2 DDX41	9.45e-05	108	79	5	IPR001650
Domain	HELICASE_CTER	DHX37 CHD2 CHD4 RAD54L2 DDX41	9.87e-05	109	79	5	PS51194
Domain	HELICASE_ATP_BIND_1	DHX37 CHD2 CHD4 RAD54L2 DDX41	9.87e-05	109	79	5	PS51192
Domain	DEXDc	DHX37 CHD2 CHD4 RAD54L2 DDX41	9.87e-05	109	79	5	SM00487
Domain	Helicase_ATP-bd	DHX37 CHD2 CHD4 RAD54L2 DDX41	1.03e-04	110	79	5	IPR014001
Domain	SNF2_N	CHD2 CHD4 RAD54L2	3.31e-04	32	79	3	IPR000330
Domain	SNF2_N	CHD2 CHD4 RAD54L2	3.31e-04	32	79	3	PF00176
Domain	DNA/RNA_helicase_DEAH_CS	DHX37 CHD2 CHD4	4.32e-04	35	79	3	IPR002464
Domain	DEAH_ATP_HELICASE	DHX37 CHD2 CHD4	5.52e-04	38	79	3	PS00690
Domain	FN3	RIMBP3 GHR RIMBP3C CMYA5 RIMBP3B	1.55e-03	199	79	5	PS50853
Domain	FN3_dom	RIMBP3 GHR RIMBP3C CMYA5 RIMBP3B	1.93e-03	209	79	5	IPR003961
Domain	-	ABCA2 GTPBP6 DHX37 MCM7 CHD2 CHD4 HNRNPUL1 RAD54L2 DDX41	4.18e-03	746	79	9	3.40.50.300
Domain	zf-DHHC	ZDHHC5 ZDHHC8	4.22e-03	23	79	2	PF01529
Domain	SH3_9	RIMBP3 RIMBP3C RIMBP3B	4.41e-03	78	79	3	PF14604
Domain	Chromo_domain	CHD2 CHD4	4.59e-03	24	79	2	IPR023780
Domain	DHHC	ZDHHC5 ZDHHC8	4.98e-03	25	79	2	PS50216
Domain	Znf_DHHC_palmitoyltrfase	ZDHHC5 ZDHHC8	4.98e-03	25	79	2	IPR001594
Domain	Chromo	CHD2 CHD4	5.38e-03	26	79	2	PF00385
Domain	SH3_2	RIMBP3 RIMBP3C RIMBP3B	5.79e-03	86	79	3	IPR011511
Domain	SH3_2	RIMBP3 RIMBP3C RIMBP3B	5.79e-03	86	79	3	PF07653
Domain	CHROMO_1	CHD2 CHD4	6.22e-03	28	79	2	PS00598
Domain	CHROMO_2	CHD2 CHD4	6.22e-03	28	79	2	PS50013
Domain	Homeobox_metazoa	MNX1 NKX1-1 NKX1-2	6.57e-03	90	79	3	IPR020479
Domain	SPRY	HNRNPUL1 CMYA5 RYR3	7.41e-03	94	79	3	PF00622
Domain	SPRY_dom	HNRNPUL1 CMYA5 RYR3	7.41e-03	94	79	3	IPR003877
Domain	B30.2/SPRY	HNRNPUL1 CMYA5 RYR3	7.63e-03	95	79	3	IPR001870
Domain	B302_SPRY	HNRNPUL1 CMYA5 RYR3	7.63e-03	95	79	3	PS50188
Domain	FN3	GHR RIMBP3C CMYA5 RIMBP3B	7.86e-03	185	79	4	SM00060
Domain	Chromodomain-like	CHD2 CHD4	8.07e-03	32	79	2	IPR016197
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION	BRPF3 CHD4 MBD3	1.12e-04	29	46	3	MM15340
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION	BRPF3 CHD4 MBD3	1.24e-04	30	46	3	M27637
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FOCAD ABCA2 ANK2 GTPBP6 PEG10 SYNE1 HECTD4 IFT122 CHD4 JAKMIP1 HNRNPUL1 RAD54L2 RAPGEF2 CMYA5 ZMYM5 RYR3	3.85e-08	1285	81	16	35914814
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	4.86e-08	4	81	3	19091768
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	1.21e-07	5	81	3	17855024
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	EEF1D DEAF1 RBM27 ZC3H15 ZNF316 CC2D1A MCM7 CHD4 HNRNPUL1 RAD54L2 DDX41 TADA3 MBD3 RBM17	2.42e-07	1103	81	14	34189442
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FOCAD ABCA2 B4GALNT4 GTPBP6 PIEZO1 ZNF316 HECTD4 ZDHHC5 CC2D1A ZDHHC8 MBD3 CASZ1 NOTCH2 IGSF3	2.47e-07	1105	81	14	35748872
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	PWP1 RBM27 ZC3H15 DHX37 SYNE1 HECTD4 CHD2 CHD4 MPND HNRNPUL1 DDX41 MBD3 RBM17	1.26e-06	1082	81	13	38697112
Pubmed	A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes.	RTL1 RTL5 PEG10	1.98e-06	11	81	3	16093683
Pubmed	Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals.	RTL1 RTL5 PEG10	1.98e-06	11	81	3	15716091
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	EEF1D RBM27 ZC3H15 CWC15 ZDHHC5 CC2D1A HNRNPUL1 VAMP4 DDX41 AKT1S1 MBD3 NOTCH2	3.67e-06	1007	81	12	34597346
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	4.35e-06	14	81	3	17662146
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	EEF1D B4GALNT4 ANK2 GTPBP6 PIEZO1 ZNF316 GON4L CHD2 RAPGEF2 CAVIN2 TULP1 RBM17 NKX1-2	4.48e-06	1215	81	13	15146197
Pubmed	Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells.	PIEZO1 PKD2	5.36e-06	2	81	2	24157948
Pubmed	Ankyrin-G palmitoylation and βII-spectrin binding to phosphoinositide lipids drive lateral membrane assembly.	ZDHHC5 ZDHHC8	5.36e-06	2	81	2	25049274
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	EEF1D DEAF1 RBM27 ZC3H15 CWC15 CHD4 HNRNPUL1 DDX41 TADA3 MBD3 RBM17	1.31e-05	954	81	11	36373674
Pubmed	PRDM16 determines specification of ventricular cardiomyocytes by suppressing alternative cell fates.	ANK2 CACNA2D2 RYR3	1.57e-05	21	81	3	39304345
Pubmed	Marlin-1, a novel RNA-binding protein associates with GABA receptors.	JAKMIP1 JAKMIP2	1.60e-05	3	81	2	14718537
Pubmed	Identification and characterization of two novel (neuro)endocrine long coiled-coil proteins.	JAKMIP1 JAKMIP2	1.60e-05	3	81	2	17572408
Pubmed	17β-estradiol-induced regulation of the novel 5-HT1A-related transcription factors NUDR and Freud-1 in SH SY5Y cells.	DEAF1 CC2D1A	1.60e-05	3	81	2	22328058
Pubmed	NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression.	CHD4 MBD3	1.60e-05	3	81	2	22139358
Pubmed	Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking.	ZDHHC5 ZDHHC8	1.60e-05	3	81	2	22325201
Pubmed	Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.	ZDHHC5 ZDHHC8	1.60e-05	3	81	2	19801377
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	PWP1 EEF1D ANK2 RBM27 DHX37 CWC15 PEG10 CC2D1A CHD2 CHD4 DDX41 MBD3 RBM17	1.63e-05	1371	81	13	36244648
Pubmed	Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation.	MNX1 NKX1-1 NKX1-2	1.82e-05	22	81	3	14645517
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	ANK2 PEG10 SYNE1 GON4L CHD2 CHD4 CMYA5 NOTCH2	2.12e-05	497	81	8	23414517
Pubmed	FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.	PWP1 DHX37 MCM7 CHD4 HNRNPUL1 RBM17	2.57e-05	248	81	6	27926873
Pubmed	Characterization of the CHD family of proteins.	CHD2 CHD4	3.20e-05	4	81	2	9326634
Pubmed	Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency.	CHD4 MBD3	5.33e-05	5	81	2	30122475
Pubmed	CircCDR1as mediates PM2.5-induced lung cancer progression by binding to SRSF1.	CDR1 CHD4	5.33e-05	5	81	2	36508830
Pubmed	MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks.	CHD4 MBD3	5.33e-05	5	81	2	18644863
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	ZBTB45 EEF1D DHX37 CWC15 SYNE1 CC2D1A CHD4 MBD3 RBM17	6.54e-05	754	81	9	35906200
Pubmed	Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.	CWC15 MCM7 CHD4 MBD3 RBM17	6.90e-05	182	81	5	26527279
Pubmed	Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity.	CHD4 MBD3	7.99e-05	6	81	2	17626165
Pubmed	A small family of sushi-class retrotransposon-derived genes in mammals and their relation to genomic imprinting.	RTL1 RTL5	7.99e-05	6	81	2	16155747
Pubmed	MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase.	CHD4 MBD3	7.99e-05	6	81	2	12354758
Pubmed	In vitro nuclear interactome of the HIV-1 Tat protein.	EEF1D MCM7 CHD4 MBD3 RBM17	9.55e-05	195	81	5	19454010
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	EEF1D RBM27 ZNF316 ZDHHC5 MCM7 CHD2 CHD4 ALCAM CASZ1 NOTCH2 IGSF3	1.07e-04	1203	81	11	29180619
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	PWP1 EEF1D CACNA2D2 ZC3H15 DHX37 SYNE1 MCM7 CHD4 HNRNPUL1 CMYA5 DDX41 MBD3	1.11e-04	1425	81	12	30948266
Pubmed	Human transcription factor protein interaction networks.	PWP1 EEF1D DEAF1 MNX1 RBM27 DHX37 PEG10 GON4L CC2D1A HNRNPUL1 RAD54L2 TADA3	1.14e-04	1429	81	12	35140242
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	EEF1D ANK2 GTPBP6 SYNE1 CHD2 IFT122 CHD4 ALCAM JAKMIP1 STOX1 RAD54L2 CAVIN2	1.24e-04	1442	81	12	35575683
Pubmed	Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors.	MNX1 RYR3	1.49e-04	8	81	2	21441923
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	ANK2 ZC3H15 CWC15 PEG10 SYNE1 PIEZO1 ZDHHC5 CC2D1A IFT122 HNRNPUL1 TADA3 NOTCH2	1.64e-04	1487	81	12	33957083
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PWP1 TBC1D30 GTPBP6 RBM27 ZC3H15 SYNE1 PIEZO1 GON4L CHD2 TADA3 MBD3 CASZ1	1.75e-04	1497	81	12	31527615
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	DEAF1 RBM27 CWC15 CHD2 CHD4 HNRNPUL1 DDX41 TADA3 MBD3 CASZ1 RBM17	2.02e-04	1294	81	11	30804502
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	PWP1 EEF1D RBM27 DHX37 CWC15 MCM7 CHD2 CHD4 HNRNPUL1 DDX41 NOTCH2	2.37e-04	1318	81	11	30463901
Pubmed	Increased interaction between DJ-1 and the Mi-2/ nucleosome remodelling and deacetylase complex during cellular stress.	CHD4 MBD3	2.38e-04	10	81	2	20127688
Pubmed	BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter.	CHD4 MBD3	2.38e-04	10	81	2	16091750
Pubmed	Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins.	KSR1 PLA2G4A	2.38e-04	10	81	2	19114553
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	BRPF3 ABCA2 RBM27 PIEZO1 UVSSA HECTD4 IGSF3	2.38e-04	529	81	7	14621295
Pubmed	Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data.	EEF1D SYNE1 CMYA5	2.48e-04	52	81	3	26499835
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	ZDHHC5 ALCAM VAMP4 ZDHHC8 NOTCH2 IGSF3	2.55e-04	377	81	6	38117590
Pubmed	Calcium signaling induces partial EMT and renal fibrosis in a Wnt4mCherry knock-in mouse model.	ANK2 PIEZO1 PKD2	2.62e-04	53	81	3	38653356
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	KSR1 BRPF3 ZC3H15 ZNF316 CHD4 RAPGEF2 DDX41 TADA3 MBD3 NOTCH2	2.65e-04	1116	81	10	31753913
Pubmed	Motor axon exit from the mammalian spinal cord is controlled by the homeodomain protein Nkx2.9 via Robo-Slit signaling.	MNX1 ALCAM	2.91e-04	11	81	2	22399681
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	PWP1 RBM27 CWC15 CHD4 HNRNPUL1 DDX41 MBD3 RBM17	3.06e-04	731	81	8	29298432
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	RBM27 GON4L MCM7 CHD2 HNRNPUL1 DDX41	3.23e-04	394	81	6	27248496
Pubmed	Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embryonic mouse gonad.	PIEZO1 CHD4 RBM17	3.25e-04	57	81	3	14595844
Pubmed	USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair.	CHD4 MBD3	3.48e-04	12	81	2	31504778
Pubmed	NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment.	CHD4 MBD3	3.48e-04	12	81	2	22560079
Pubmed	Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development.	CHD4 MBD3	3.48e-04	12	81	2	20720167
Pubmed	Apocrine glands are bystanders in hidradenitis suppurativa and their involvement is gender specific.	RBM27 SYNE1 CMYA5	3.60e-04	59	81	3	32031713
Pubmed	Nuclear Functions of Nucleolin through Global Proteomics and Interactomic Approaches.	PWP1 ZC3H15 CHD4 DDX41	3.76e-04	145	81	4	27049334
Pubmed	Defining the membrane proteome of NK cells.	KSR1 ABCA2 ZDHHC5 CC2D1A MCM7 IFT122 CHD4 DDX41 F5 NOTCH2	3.80e-04	1168	81	10	19946888
Pubmed	The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2.	CHD4 MBD3	4.11e-04	13	81	2	12124384
Pubmed	LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer.	CHD4 MBD3	4.11e-04	13	81	2	19703393
Pubmed	Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3.	GHR MNX1 CASZ1	4.37e-04	63	81	3	25053427
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PWP1 DEAF1 PLA2G4A CHD4 HNRNPUL1 DDX41 AKT1S1 NOTCH2	4.47e-04	774	81	8	15302935
Pubmed	TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas.	MCM7 CHD2 CHD4 HNRNPUL1	4.49e-04	152	81	4	28192407
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	ZDHHC5 CC2D1A MCM7 CHD4 HNRNPUL1 RAPGEF2 NOTCH2 IGSF3	4.58e-04	777	81	8	35844135
Pubmed	GATA-1 forms distinct activating and repressive complexes in erythroid cells.	CHD4 MBD3	4.79e-04	14	81	2	15920471
Pubmed	MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.	CHD4 MBD3	4.79e-04	14	81	2	16428440
Pubmed	Complex interactions between genes controlling trafficking in primary cilia.	MNX1 IFT122	4.79e-04	14	81	2	21552265
Pubmed	Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord.	MNX1 ALCAM JAKMIP1 F5	4.95e-04	156	81	4	22008794
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	DEAF1 DHX37 CHD2 CHD4 DDX41 MBD3 CASZ1	5.48e-04	608	81	7	36089195
Pubmed	Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis.	CHD4 MBD3	5.52e-04	15	81	2	30135474
Pubmed	The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1.	CHD4 MBD3	5.52e-04	15	81	2	25247294
Pubmed	Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.	CHD4 MBD3	5.52e-04	15	81	2	9804427
Pubmed	NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development.	CHD4 MBD3	5.52e-04	15	81	2	19927129
Pubmed	MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.	CHD4 MBD3	5.52e-04	15	81	2	15701600
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	PWP1 RBM27 HECTD4 MCM7 CHD4 HNRNPUL1	5.78e-04	440	81	6	34244565
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	EEF1D ZC3H15 CHD4 RBM17	5.84e-04	163	81	4	22113938
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	EEF1D RBM27 MCM7 CHD2 CHD4 DDX41 TADA3 MBD3 RBM17	5.86e-04	1014	81	9	32416067
Pubmed	Laminar organization of the early developing anterior hypothalamus.	ALCAM NKX1-2	6.29e-04	16	81	2	16860307
Pubmed	Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system.	ZDHHC5 ZDHHC8	6.29e-04	16	81	2	23034182
Pubmed	Modifier genes and protective alleles in humans and mice.	PLA2G4A NOTCH2	6.29e-04	16	81	2	12787792
Pubmed	RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation.	CHD4 MBD3	6.29e-04	16	81	2	30760870
Pubmed	Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.	CHD4 MBD3	6.29e-04	16	81	2	11102443
Pubmed	Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.	HECTD4 CASZ1	6.29e-04	16	81	2	21572416
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	ZC3H15 SYNE1 JAKMIP2 RYR3	6.54e-04	168	81	4	30631154
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	GTPBP6 CACNA2D2 UVSSA HECTD4 PKD2 CHD2 IFT122 ALCAM RAPGEF2 CASZ1 NOTCH2	6.60e-04	1489	81	11	28611215
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	PWP1 EEF1D RBM27 ZC3H15 DHX37 CWC15 MCM7 HNRNPUL1 DDX41 F5	6.72e-04	1257	81	10	36526897
Pubmed	Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.	EEF1D OGFR CHD4 MBD3	6.84e-04	170	81	4	16159877
Pubmed	Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.	BRPF3 CHD4 MBD3	7.28e-04	75	81	3	25593309
Pubmed	Mi-2/NuRD is required in renal progenitor cells during embryonic kidney development.	CHD4 MBD3	8.00e-04	18	81	2	23201013
Pubmed	The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.	CHD4 MBD3	8.00e-04	18	81	2	9790534
Pubmed	Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region.	CHD4 MBD3	8.00e-04	18	81	2	16217013
Pubmed	Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4.	MNX1 IFT122	8.00e-04	18	81	2	19000668
Pubmed	Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.	CHD4 MBD3	8.00e-04	18	81	2	10444591
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	PWP1 EEF1D RBM27 DHX37 PEG10 CHD4 CAVIN2 RBM17	8.04e-04	847	81	8	35850772
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	RBM27 ZDHHC5 RAD54L2 NOTCH2	8.46e-04	180	81	4	35198878
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	PWP1 EEF1D MCM7 CHD4 HNRNPUL1 DDX41 MBD3	8.48e-04	655	81	7	35819319
Cytoband	22q11.21	RIMBP3 RIMBP3C RIMBP3B ZDHHC8	4.66e-05	111	81	4	22q11.21
Cytoband	Ensembl 112 genes in cytogenetic band chr22q11	RIMBP3 DRICH1 RIMBP3C RIMBP3B ZDHHC8	8.97e-04	419	81	5	chr22q11
GeneFamily	PHD finger proteins\|NuRD complex	CHD4 MBD3	5.46e-04	12	53	2	1305
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLA2G4A PLCD4	1.40e-03	19	53	2	832
GeneFamily	Zinc fingers DHHC-type\|Ankyrin repeat domain containing	ZDHHC5 ZDHHC8	2.23e-03	24	53	2	76
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ASPN C3orf80 ALCAM CAVIN2 RYR3	1.52e-05	171	81	5	fe0665c5ca01b0b2cc8f20d64587f0847c3d215c
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BRPF3 ANK2 SYNE1 HECTD4 ZDHHC8	1.70e-05	175	81	5	1d8aab491dcc27ea5dbfb6462d18ee280b21a05e
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BRPF3 ANK2 SYNE1 HECTD4 ZDHHC8	1.70e-05	175	81	5	427a7ee92fe16a90625946492062d37aa0f7235b
ToppCell	COVID_non-vent-Lymphocytic-T_cell-CD8+_Memory_T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	ABCA2 CACNA2D2 SYNE1 JAKMIP1 JAKMIP2	2.99e-05	197	81	5	836061acd7f0d5de89b16f52ec679bdf09eac9db
ToppCell	Tracheal-10x3prime_v2-Stromal-Mesofibroblastic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ANK2 ASPN PEG10 PKD2 AKT1S1	2.99e-05	197	81	5	d7cef7881abd807a679432766ced609a6efd1067
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CACNA2D2 PPP1R14C SYNE1 JAKMIP1 JAKMIP2	2.99e-05	197	81	5	ff34be81ee77efe60618641fa7c1084442b991d7
ToppCell	Tracheal-10x3prime_v2-Stromal-Mesofibroblastic-Mesothelia\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ANK2 ASPN PEG10 PKD2 AKT1S1	2.99e-05	197	81	5	20a5958512bdb99daeb8f4d244df53e4f048f879
ToppCell	Sepsis-ICU-SEP-Lymphocyte-T/NK-gd_T\|ICU-SEP / Disease, condition lineage and cell class	CAPN12 SYNE1 STOX1 ASPRV1 JAKMIP2	3.07e-05	198	81	5	b40899f8f5f32420fb4574069dd7afd9e7e70d91
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	GHR ASPN SYNE1 PKD2 ALCAM	3.22e-05	200	81	5	c5e051f1aac8dda376c342a9932785a23450e073
ToppCell	Tracheal-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Serous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CAPN12 CDR1 TBC1D30 PEG10 F5	3.22e-05	200	81	5	e9908b6cba21a59023cf8d0f98fbd1d1f7de6b44
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	GHR ASPN SYNE1 PKD2 ALCAM	3.22e-05	200	81	5	9d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	GHR ASPN SYNE1 PKD2 ALCAM	3.22e-05	200	81	5	dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
Disease	Myoclonic Astatic Epilepsy	CHD2 RAPGEF2	3.36e-04	11	74	2	C0393702
Disease	Acute Cerebrovascular Accidents	ANK2 F5 CASZ1	3.43e-04	54	74	3	C0751956
Disease	Autistic Disorder	GHR PLA2G4A CHD4 JAKMIP1 MBD3	5.10e-04	261	74	5	C0004352
Disease	Cerebrovascular accident	ANK2 F5 CASZ1	5.15e-04	62	74	3	C0038454
Disease	alpha-L-iduronidase measurement	UVSSA NKX1-1	8.24e-04	17	74	2	EFO_0020139
Disease	COVID-19, mortality	B4GALNT4 ZNF316 ALCAM JAKMIP2	8.94e-04	170	74	4	EFO_0004352, MONDO_0100096
Disease	pre-eclampsia (is_implicated_in)	STOX1 F5	1.79e-03	25	74	2	DOID:10591 (is_implicated_in)
Disease	osteoarthritis (is_implicated_in)	GHR ASPN	2.25e-03	28	74	2	DOID:8398 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
EDRPAEDSEDEVLAE	TADA3	331	O75528
PTLAREDNEEDEDEP	AKT1S1	96	Q96B36
ADAELDDPESEDVER	CACNA2D2	166	Q9NY47
DDEDLRTDSEESLPE	CASZ1	1711	Q86V15
ALQEEPEDDGDRDDS	BRPF3	816	Q9ULD4
ANLDADDPLTDEEDE	CWC15	101	Q9P013
CDRDDEEDLLDDPSL	RAD54L2	36	Q9Y4B4
IEALAPDDDDDDEDE	CCM2L	541	Q9NUG4
PDDDDDDEDEPRGSR	CCM2L	546	Q9NUG4
DVDLLEDTDFLEDPD	CDR1	96	P51861
ATPAEDDEDDDIDLF	EEF1D	146	P29692
DDDDDDEDNSLFPTR	ASPN	46	Q9BXN1
LQDYRLPDSDDDEDE	ZFYVE19	346	Q96K21
ETSDLFLPDDDDEDE	RBM27	1036	Q9P2N5
LDRDTASEVDDLEPD	RIMBP3B	801	A6NNM3
LDRDTASEVDDLEPD	RIMBP3C	801	A6NJZ7
DDEADLLPDDVSEEV	ANK2	3176	Q01484
AEDEALLSEEDDPID	NOTCH2	1771	Q04721
PDDDLDESLAAEESE	JAKMIP2	461	Q96AA8
EEEDDSPRDDNLEER	IFT122	236	Q9HBG6
PLDKACAEDDDEEDE	MBD3	261	O95983
EEPEDADENAEEELL	GTPBP6	71	O43824
LRDSDPEEDEDEDDE	MNX1	351	P50219
ADVLEAHEAEAEEPE	KSR1	551	Q8IVT5
AEDDEDEVDDLPSSR	KSR1	571	Q8IVT5
TPEDEDDDIELRGAA	PEG10	51	Q86TG7
PEEDLDDATAREEAD	JAKMIP1	471	Q96N16
DEDEAEAEDPERPNA	MPND	21	Q8N594
SRSEAEDEDDEDYVP	DDX41	21	Q9UJV9
IADDESDDDDDDDIP	HECTD4	2231	Q9Y4D8
DLDDVAEDDPELVDS	MCM7	51	P33993
RLTLLEPDEEDDEDE	CAPN12	386	Q6ZSI9
DDDDDDPTERTALLS	IGSF3	1021	O75054
EDADEDEDAAAARRA	DACT3	61	Q96B18
DEPDEKTEESDTDRL	GHR	351	P10912
DSSDEDDDDDEAPKR	CHD2	206	O14647
EAEEPVLSRDEDSEE	DEAF1	36	O75398
DTVRADDDEENESPA	FBXO9	21	Q9UK97
EDETAAESEEEPDSR	CMYA5	36	Q8N3K9
PDDEEEDETAEESLL	GON4L	376	Q3T8J9
DDDDDSPALLRDEAA	C3orf80	136	F5H4A9
GTDEDDLEADDDLLA	CC2D1A	91	Q6P1N0
ALVADEPEDLDTEDE	ABCA2	2401	Q9BZC7
EVADEEEEREHDLPT	FAM163A	41	Q96GL9
AYDDLDQEDPDDDLD	ELP5	301	Q8TE02
DDLPHDEEALEDSAE	CAVIN2	206	O95810
EEGDEDFDERSEAPR	CHD4	1371	Q14839
SELEEESELDEDPAA	DHX37	171	Q8IY37
ELFEELDRPAASDEE	DHX37	811	Q8IY37
PEHDEADEISDENRE	ALCAM	506	Q13740
LDDDEDVEDVDLSVP	FOCAD	741	Q5VW36
LPRSEDDDCDDDDDD	DRICH1	111	Q6PGQ1
ERLQAALEAEEPDDE	HNRNPUL1	31	Q9BUJ2
ALEAEEPDDERELDA	HNRNPUL1	36	Q9BUJ2
IDIDDLLDADSDEER	PPP1R14C	111	Q8TAE6
FDDDELDAAVADPDE	PLA2G4A	516	P47712
ADAGDEDEESEEPRA	OGFR	36	Q9NZT2
EQARLEELPDEDEDA	RTL1	1341	A6NKG5
VEEEPLDEAQDDDLD	RTL5	451	Q5HYW3
RRTEALGDAEEDEDD	UVSSA	391	Q2YD98
ERRNLLEDDSDEEED	VAMP4	21	O75379
EEEEAEPELEESELA	PLCD4	446	Q9BRC7
PDDEHDLSDRELELE	SYNE1	8216	Q8NF91
DRLEPEDEESDADYD	F5	711	P12259
DDEDEAPETEAARGA	NKX1-1	196	Q15270
GSEAEEEEDAEDPRR	NKX1-2	86	Q9UD57
LDRDTASEVDDLEPD	RIMBP3	801	Q9UFD9
PDDFLDDEDEGELLD	B4GALNT4	431	Q76KP1
DEFDLELIEEDPSSE	ASPRV1	321	Q53RT3
EDDDDEEDIERASDP	RAPGEF2	86	Q9Y4G8
FLVARAPDAEDEEEE	TULP1	106	O00294
LEDGDPEDDRTLDDD	PWP1	76	Q13610
PEDDRTLDDDELAEY	PWP1	81	Q13610
AAPDDRGDEDDEESD	ZBTB45	201	Q96K62
DSADRPEEEEEDEDS	RYR3	4106	Q15413
DEDDLDNIPRDVEHE	STOX1	346	Q6ZVD7
PDPDSDEDEDYERER	RBM17	151	Q96I25
KARDSDEENDPDDED	TBC1D30	551	Q9Y2I9
PRSLDDSEEDDDEDS	PKD2	806	Q13563
AEEDEDKEDDFRAPL	ZDHHC5	76	Q9C0B5
SRNSPVEDDDDDDDV	ZMYM5	46	Q9UJ78
DGEAEAAAEEREEAA	ZNF316	546	A6NFI3
ADEDEDKEDDFRAPL	ZDHHC8	76	Q9ULC8
LPSRDSSEEEEEEEE	PLEKHG2	586	Q9H7P9
HPRELDDDERDVDAS	PIEZO1	151	Q92508
EFRPELVNDDDEEAD	ZC3H15	296	Q8WU90