Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	spectrin binding	SAG UNC13A EPB41L2	1.01e-05	34	25	3	GO:0030507
GeneOntologyMolecularFunction	PH domain binding	NCL EPB41L2	5.39e-05	9	25	2	GO:0042731
GeneOntologyMolecularFunction	protein domain specific binding	NCL SLC9A3 CTNND1 APP UNC13A EPB41L2	6.02e-04	875	25	6	GO:0019904
GeneOntologyBiologicalProcess	regulation of peptidyl-tyrosine phosphorylation	NCL CTNND1 APP PECAM1 TGFA	1.65e-05	272	25	5	GO:0050730
GeneOntologyBiologicalProcess	peptidyl-tyrosine phosphorylation	NCL CTNND1 APP PECAM1 TGFA	3.98e-05	327	25	5	GO:0018108
GeneOntologyBiologicalProcess	peptidyl-tyrosine modification	NCL CTNND1 APP PECAM1 TGFA	4.09e-05	329	25	5	GO:0018212
GeneOntologyBiologicalProcess	regulation of synaptic vesicle priming	RAB3GAP1 UNC13A	1.27e-04	14	25	2	GO:0010807
GeneOntologyBiologicalProcess	regulation of neuronal synaptic plasticity	RAB3GAP1 APP UNC13A	1.36e-04	83	25	3	GO:0048168
GeneOntologyBiologicalProcess	positive regulation of synaptic transmission	RAB3GAP1 STX4 APP UNC13A	1.67e-04	233	25	4	GO:0050806
GeneOntologyBiologicalProcess	synaptic vesicle docking	STX4 UNC13A	1.90e-04	17	25	2	GO:0016081
GeneOntologyBiologicalProcess	neurotransmitter transport	RAB3GAP1 STX4 APP UNC13A	2.50e-04	259	25	4	GO:0006836
GeneOntologyBiologicalProcess	exocytic process	RAB3GAP1 STX4 UNC13A	2.87e-04	107	25	3	GO:0140029
GeneOntologyBiologicalProcess	G protein-coupled receptor internalization	SAG APP	2.92e-04	21	25	2	GO:0002031
GeneOntologyBiologicalProcess	regulation of short-term neuronal synaptic plasticity	RAB3GAP1 UNC13A	3.21e-04	22	25	2	GO:0048172
GeneOntologyBiologicalProcess	regulation of synaptic plasticity	RAB3GAP1 STX4 APP UNC13A	3.99e-04	293	25	4	GO:0048167
GeneOntologyBiologicalProcess	positive regulation of neurotransmitter secretion	RAB3GAP1 UNC13A	4.16e-04	25	25	2	GO:0001956
GeneOntologyBiologicalProcess	calcium ion-regulated exocytosis of neurotransmitter	RAB3GAP1 UNC13A	4.16e-04	25	25	2	GO:0048791
GeneOntologyBiologicalProcess	synaptic vesicle exocytosis	RAB3GAP1 STX4 UNC13A	4.53e-04	125	25	3	GO:0016079
GeneOntologyBiologicalProcess	positive regulation of cell cycle process	TPR SGO2 APP TGFA	4.76e-04	307	25	4	GO:0090068
GeneOntologyBiologicalProcess	positive regulation of protein localization	TPR STX4 APP EPB41L2 PECAM1	6.27e-04	591	25	5	GO:1903829
GeneOntologyBiologicalProcess	desensitization of G protein-coupled receptor signaling pathway	SAG APP	6.42e-04	31	25	2	GO:0002029
GeneOntologyBiologicalProcess	synaptic vesicle priming	RAB3GAP1 UNC13A	6.42e-04	31	25	2	GO:0016082
GeneOntologyBiologicalProcess	regulation of neurotransmitter transport	RAB3GAP1 APP UNC13A	6.44e-04	141	25	3	GO:0051588
GeneOntologyBiologicalProcess	negative adaptation of signaling pathway	SAG APP	6.84e-04	32	25	2	GO:0022401
GeneOntologyBiologicalProcess	adaptation of signaling pathway	SAG APP	6.84e-04	32	25	2	GO:0023058
GeneOntologyBiologicalProcess	positive regulation of neurotransmitter transport	RAB3GAP1 UNC13A	6.84e-04	32	25	2	GO:0051590
GeneOntologyBiologicalProcess	long-term synaptic potentiation	STX4 APP UNC13A	6.85e-04	144	25	3	GO:0060291
GeneOntologyBiologicalProcess	vesicle docking involved in exocytosis	STX4 UNC13A	1.29e-03	44	25	2	GO:0006904
GeneOntologyBiologicalProcess	positive regulation of secretion by cell	RAB3GAP1 STX4 GALR1 UNC13A	1.32e-03	404	25	4	GO:1903532
GeneOntologyBiologicalProcess	positive regulation of cell cycle	TPR SGO2 APP TGFA	1.36e-03	407	25	4	GO:0045787
GeneOntologyCellularComponent	cell surface	NCL SLC9A3 STX4 CTNND1 APP PECAM1 TGFA	1.83e-04	1111	24	7	GO:0009986
GeneOntologyCellularComponent	neuromuscular junction	NEFM APP UNC13A	2.79e-04	112	24	3	GO:0031594
GeneOntologyCellularComponent	presynaptic active zone cytoplasmic component	CTNND1 UNC13A	3.15e-04	23	24	2	GO:0098831
GeneOntologyCellularComponent	presynaptic active zone	CTNND1 APP UNC13A	5.48e-04	141	24	3	GO:0048786
GeneOntologyCellularComponent	cell cortex	NCL CTNND1 UNC13A EPB41L2	7.83e-04	371	24	4	GO:0005938
GeneOntologyCellularComponent	cell cortex region	CTNND1 UNC13A	1.21e-03	45	24	2	GO:0099738
GeneOntologyCellularComponent	lamellipodium	STX4 CTNND1 APP	2.24e-03	230	24	3	GO:0030027
GeneOntologyCellularComponent	cell leading edge	STX4 CTNND1 APP PECAM1	2.35e-03	500	24	4	GO:0031252
GeneOntologyCellularComponent	dendritic spine	STX4 CTNND1 APP	2.59e-03	242	24	3	GO:0043197
GeneOntologyCellularComponent	neuron spine	STX4 CTNND1 APP	2.75e-03	247	24	3	GO:0044309
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	NCL SLC9A3 STX4 UNC13A PECAM1 TGFA	3.00e-03	1307	24	6	GO:0030659
GeneOntologyCellularComponent	vesicle membrane	NCL SLC9A3 STX4 UNC13A PECAM1 TGFA	3.21e-03	1325	24	6	GO:0012506
GeneOntologyCellularComponent	intermediate filament cytoskeleton	NEFM DDX60 SAP30BP	3.28e-03	263	24	3	GO:0045111
GeneOntologyCellularComponent	inclusion body	NEFM TPR	4.76e-03	90	24	2	GO:0016234
GeneOntologyCellularComponent	platelet alpha granule	APP PECAM1	5.07e-03	93	24	2	GO:0031091
GeneOntologyCellularComponent	postsynapse	NEFM RAB3GAP1 STX4 CTNND1 APP	5.32e-03	1018	24	5	GO:0098794
GeneOntologyCellularComponent	excitatory synapse	RAB3GAP1 UNC13A	6.66e-03	107	24	2	GO:0060076
GeneOntologyCellularComponent	COPII-coated ER to Golgi transport vesicle	APP TGFA	7.02e-03	110	24	2	GO:0030134
GeneOntologyCellularComponent	Golgi-associated vesicle	APP UNC13A	7.52e-03	114	24	2	GO:0005798
GeneOntologyCellularComponent	lipid droplet	RAB3GAP1 SDR16C5	7.78e-03	116	24	2	GO:0005811
GeneOntologyCellularComponent	membrane raft	CTNND1 APP PECAM1	7.96e-03	362	24	3	GO:0045121
GeneOntologyCellularComponent	membrane microdomain	CTNND1 APP PECAM1	8.08e-03	364	24	3	GO:0098857
Domain	ARM_REPEAT	ARMCX5 CTNND1	1.20e-03	40	24	2	PS50176
Domain	Armadillo	ARMCX5 CTNND1	1.65e-03	47	24	2	IPR000225
Domain	DEAD	DDX46 DDX60	3.93e-03	73	24	2	PF00270
Domain	DEAD/DEAH_box_helicase_dom	DDX46 DDX60	3.93e-03	73	24	2	IPR011545
Domain	Helicase_C	DDX46 DDX60	8.27e-03	107	24	2	PF00271
Domain	HELICc	DDX46 DDX60	8.27e-03	107	24	2	SM00490
Domain	Helicase_C	DDX46 DDX60	8.42e-03	108	24	2	IPR001650
Domain	HELICASE_CTER	DDX46 DDX60	8.57e-03	109	24	2	PS51194
Domain	HELICASE_ATP_BIND_1	DDX46 DDX60	8.57e-03	109	24	2	PS51192
Domain	DEXDc	DDX46 DDX60	8.57e-03	109	24	2	SM00487
Domain	Helicase_ATP-bd	DDX46 DDX60	8.72e-03	110	24	2	IPR014001
Pubmed	Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding.	TPR NCL DDX46 SAP30BP	2.07e-07	72	25	4	31248990
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	TPR NCL DDX46 STX4 CTNND1 APP EPB41L2 SUPT16H	3.81e-07	1024	25	8	24711643
Pubmed	p120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptide.	CTNND1 APP	4.96e-07	2	25	2	19008223
Pubmed	As human lung microvascular endothelia achieve confluence, src family kinases are activated, and tyrosine-phosphorylated p120 catenin physically couples NEU1 sialidase to CD31.	CTNND1 PECAM1	1.49e-06	3	25	2	28343945
Pubmed	APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle.	RAB3GAP1 APP	1.49e-06	3	25	2	19923287
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	TPR NCL DDX46 SAP30BP SUPT16H	1.60e-06	283	25	5	30585729
Pubmed	A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells.	TPR NCL DDX46 SAP30BP	1.67e-06	121	25	4	22412018
Pubmed	Rab3 GTPase-activating protein regulates synaptic transmission and plasticity through the inactivation of Rab3.	RAB3GAP1 UNC13A	2.97e-06	4	25	2	16782817
Pubmed	Complexity in transcription control at the activation domain-mediator interface.	NEFM PECAM1	2.97e-06	4	25	2	19417216
Pubmed	Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing.	APP UNC13A	2.97e-06	4	25	2	15123597
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	NEFM TPR DDX46 CTNND1 EPB41L2 SUPT16H	3.68e-06	607	25	6	39147351
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NEFM TPR NCL CTNND1 UNC13A EPB41L2 SUPT16H	3.79e-06	963	25	7	28671696
Pubmed	Neurodegeneration Markers in the Cerebrospinal Fluid of 100 Patients with Schizophrenia Spectrum Disorder.	NEFM APP	4.95e-06	5	25	2	36200879
Pubmed	Endothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis.	SAG PECAM1	4.95e-06	5	25	2	24213570
Pubmed	p120-Catenin is required for mouse vascular development.	CTNND1 PECAM1	7.43e-06	6	25	2	20110533
Pubmed	Quantitative trait analysis of nickel-induced acute lung injury in mice.	PECAM1 TGFA	7.43e-06	6	25	2	11415940
Pubmed	EpCAM is essential for maintenance of the small intestinal epithelium architecture via regulation of the expression and localization of proteins that compose adherens junctions.	CTNND1 PECAM1	7.43e-06	6	25	2	33416101
Pubmed	JunB regulates angiogenesis and neurovascular parallel alignment in mouse embryonic skin.	NEFM PECAM1	7.43e-06	6	25	2	28096474
Pubmed	NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport.	NEFM APP	7.43e-06	6	25	2	38282024
Pubmed	Chromatin accessibility complex subunit 1 enhances tumor growth by regulating the oncogenic transcription of YAP in breast and cervical cancer.	TPR CTNND1 EPB41L2	9.36e-06	57	25	3	38223760
Pubmed	Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1.	NEFM PECAM1	1.04e-05	7	25	2	38526535
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	TPR RAB3GAP1 NCL CTNND1 APP UNC13A EPB41L2	1.14e-05	1139	25	7	36417873
Pubmed	Nestin is not essential for development of the CNS but required for dispersion of acetylcholine receptor clusters at the area of neuromuscular junctions.	NEFM PECAM1	1.39e-05	8	25	2	21832185
Pubmed	Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development.	NEFM PECAM1	1.39e-05	8	25	2	12852851
Pubmed	Temporal regulation of EphA4 in astroglia during murine retinal and optic nerve development.	NEFM PECAM1	1.39e-05	8	25	2	16574431
Pubmed	β8 integrin and band 4.1B cooperatively regulate morphogenesis of the embryonic heart.	NEFM PECAM1	1.39e-05	8	25	2	21181944
Pubmed	Essential roles of Meltrin beta (ADAM19) in heart development.	NEFM PECAM1	1.39e-05	8	25	2	14975714
Pubmed	The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase.	NCL DDX46 APP SUPT16H	1.78e-05	220	25	4	34091597
Pubmed	APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice.	NEFM APP	1.78e-05	9	25	2	23986861
Pubmed	Inactivation of the Sema5a gene results in embryonic lethality and defective remodeling of the cranial vascular system.	NEFM PECAM1	1.78e-05	9	25	2	15743826
Pubmed	Multiple roles of mouse Numb in tuning developmental cell fates.	NEFM PECAM1	1.78e-05	9	25	2	11412999
Pubmed	Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos.	NEFM PECAM1	1.78e-05	9	25	2	26460546
Pubmed	Report and abstracts of the Fourth International Workshop on Human Chromosome 2 Mapping 1996.	NCL SAG TGFA	1.82e-05	71	25	3	8751373
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	TPR NCL CTNND1 DDX60 EPB41L2 SAP30BP SUPT16H	2.15e-05	1257	25	7	36526897
Pubmed	Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb.	NEFM PECAM1	2.22e-05	10	25	2	21364975
Pubmed	Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects.	NEFM PECAM1	2.22e-05	10	25	2	18992737
Pubmed	Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins.	NEFM PECAM1	2.22e-05	10	25	2	15550623
Pubmed	The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4.	NCL TGFA	2.22e-05	10	25	2	8702723
Pubmed	Developmental origin and morphogenesis of the diaphragm, an essential mammalian muscle.	NEFM PECAM1	2.22e-05	10	25	2	29679560
Pubmed	A phenotype-driven ENU mutagenesis screen identifies novel alleles with functional roles in early mouse craniofacial development.	NEFM PECAM1	2.22e-05	10	25	2	21305688
Pubmed	Loss of Gbx2 results in neural crest cell patterning and pharyngeal arch artery defects in the mouse embryo.	NEFM PECAM1	2.22e-05	10	25	2	15996652
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	NEFM SGO2 DDX46 EPB41L2	2.30e-05	235	25	4	30258100
Pubmed	Probing nuclear pore complex architecture with proximity-dependent biotinylation.	TPR ZNF740 EPB41L2	2.32e-05	77	25	3	24927568
Pubmed	MEMO1 drives cranial endochondral ossification and palatogenesis.	NEFM PECAM1	2.72e-05	11	25	2	26746790
Pubmed	Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart.	NEFM PECAM1	2.72e-05	11	25	2	12404118
Pubmed	Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature.	NEFM PECAM1	2.72e-05	11	25	2	26385750
Pubmed	Establishment of neurovascular congruency in the mouse whisker system by an independent patterning mechanism.	NEFM PECAM1	2.72e-05	11	25	2	24139045
Pubmed	Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero.	NEFM PECAM1	2.72e-05	11	25	2	21536740
Pubmed	The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.	TPR SGO2 NCL	3.23e-05	86	25	3	37253089
Pubmed	Pitx2-mediated cardiac outflow tract remodeling.	NEFM PECAM1	3.26e-05	12	25	2	23361844
Pubmed	Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice.	NEFM PECAM1	3.26e-05	12	25	2	18521186
Pubmed	UIF, a New mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA.	NCL SUPT16H	3.85e-05	13	25	2	19836239
Pubmed	Platelet-derived growth factor over-expression in retinal progenitors results in abnormal retinal vessel formation.	NEFM PECAM1	3.85e-05	13	25	2	22880002
Pubmed	Peripheral nerve-derived CXCL12 and VEGF-A regulate the patterning of arterial vessel branching in developing limb skin.	NEFM PECAM1	3.85e-05	13	25	2	23395391
Pubmed	Semaphorin 3G Provides a Repulsive Guidance Cue to Lymphatic Endothelial Cells via Neuropilin-2/PlexinD1.	NEFM PECAM1	3.85e-05	13	25	2	27880905
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	NEFM TPR DDX46 CTNND1 SAP30BP	3.94e-05	549	25	5	38280479
Pubmed	PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential.	RAB3GAP1 CTNND1 APP	4.21e-05	94	25	3	32062451
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	TPR NCL DDX46 CTNND1 EPB41L2 SAP30BP	4.22e-05	934	25	6	33916271
Pubmed	Membrane β-catenin and adherens junctions in early gonadal patterning.	CTNND1 PECAM1	4.49e-05	14	25	2	22972715
Pubmed	The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence.	CTNND1 PECAM1	4.49e-05	14	25	2	22144466
Pubmed	Astrocyte-intrinsic and -extrinsic Fat1 activities regulate astrocyte development and angiogenesis in the retina.	NEFM PECAM1	4.49e-05	14	25	2	35050341
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	TPR SGO2 NCL DDX46 SAP30BP SUPT16H	4.75e-05	954	25	6	36373674
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	MKX ZNF740 RAB3GAP1 DDX46 STX4 DDX60 SUPT16H	5.12e-05	1440	25	7	30833792
Pubmed	Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development.	CTNND1 PECAM1	5.18e-05	15	25	2	18393386
Pubmed	Phenotypic analysis of mice completely lacking netrin 1.	NEFM PECAM1	5.18e-05	15	25	2	26395479
Pubmed	Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability.	NEFM PECAM1	5.18e-05	15	25	2	18345009
Pubmed	Loss of MYO5B in mice recapitulates Microvillus Inclusion Disease and reveals an apical trafficking pathway distinct to neonatal duodenum.	SLC9A3 CTNND1	5.92e-05	16	25	2	27019864
Pubmed	Mesodermal expression of integrin α5β1 regulates neural crest development and cardiovascular morphogenesis.	NEFM PECAM1	5.92e-05	16	25	2	25242040
Pubmed	Mechanical loading is required for initiation of extracellular matrix deposition at the developing murine myotendinous junction.	NEFM PECAM1	5.92e-05	16	25	2	36709857
Pubmed	Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.	TPR CTNND1 SUPT16H	6.03e-05	106	25	3	19394292
Pubmed	The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.	NEFM NCL CTNND1 EPB41L2 SUPT16H	6.19e-05	604	25	5	37616343
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	RAB3GAP1 NCL CTNND1 APP CASKIN2 EPB41L2 SUPT16H	6.28e-05	1487	25	7	33957083
Pubmed	Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation.	ZNF740 CTNND1 APP EPB41L2	6.34e-05	305	25	4	21244100
Pubmed	Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse development.	NEFM PECAM1	6.70e-05	17	25	2	19161597
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	ZNF740 RAB3GAP1 NCL SLC9A3 APP SAP30BP	6.92e-05	1021	25	6	26760575
Pubmed	Loss of transforming growth factor-beta 2 leads to impairment of central synapse function.	NEFM UNC13A	7.54e-05	18	25	2	18854036
Pubmed	Meis2 is essential for cranial and cardiac neural crest development.	NEFM PECAM1	7.54e-05	18	25	2	26545946
Pubmed	p120-catenin regulates WNT signaling and EMT in the mouse embryo.	CTNND1 PECAM1	8.42e-05	19	25	2	31371508
Pubmed	p120 catenin is required for normal renal tubulogenesis and glomerulogenesis.	CTNND1 PECAM1	8.42e-05	19	25	2	21521738
Pubmed	Loss of microRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects.	NEFM PECAM1	8.42e-05	19	25	2	20884876
Pubmed	PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development.	NEFM PECAM1	8.42e-05	19	25	2	15239958
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	NEFM TPR SGO2 NCL SUPT16H	8.88e-05	652	25	5	31180492
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	NEFM TPR NCL DDX46 EPB41L2	8.94e-05	653	25	5	22586326
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	TPR DDX46 CTNND1 EPB41L2 SUPT16H	9.40e-05	660	25	5	32780723
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	MKX NEFM NCL DDX46 UNC13A SUPT16H	9.53e-05	1082	25	6	38697112
Pubmed	LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction.	NEFM PECAM1	1.03e-04	21	25	2	17119023
Pubmed	Glial cells maintain synapses by inhibiting an activity-dependent retrograde protease signal.	NEFM PECAM1	1.14e-04	22	25	2	30870413
Pubmed	The Wheels mutation in the mouse causes vascular, hindbrain, and inner ear defects.	NEFM PECAM1	1.14e-04	22	25	2	11356033
Pubmed	The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.	CTNND1 APP TGFA	1.21e-04	134	25	3	24658140
Pubmed	In silico prediction of physical protein interactions and characterization of interactome orphans.	CTNND1 APP TGFA	1.26e-04	136	25	3	25402006
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	NEFM TPR NCL DDX46 EPB41L2 SUPT16H	1.32e-04	1149	25	6	35446349
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	TPR NCL DDX46 CTNND1 SUPT16H	1.33e-04	711	25	5	33022573
Pubmed	Neural crest cell-autonomous roles of fibronectin in cardiovascular development.	NEFM PECAM1	1.36e-04	24	25	2	26552887
Pubmed	PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins.	NEFM GALR1	1.36e-04	24	25	2	28413018
Pubmed	Motor innervation directs the correct development of the mouse sympathetic nervous system.	NEFM PECAM1	1.47e-04	25	25	2	39152112
Pubmed	Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla.	NEFM PECAM1	1.60e-04	26	25	2	28684471
Pubmed	Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.	NEFM UNC13A	1.60e-04	26	25	2	17124501
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	SGO2 NCL SAP30BP	1.62e-04	148	25	3	32538781
Pubmed	DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination.	EPB41L2 SUPT16H	1.85e-04	28	25	2	32937373
Pubmed	Isolation and characterization of proteins associated with histone H3 tails in vivo.	NCL SUPT16H	2.13e-04	30	25	2	17403666
Interaction	ABCC12 interactions	NEFM TPR NCL	3.68e-07	12	25	3	int:ABCC12
Interaction	RAB5A interactions	TPR RAB3GAP1 NCL SLC9A3 STX4 CTNND1 TGFA	1.74e-05	706	25	7	int:RAB5A
Interaction	NSD2 interactions	TPR NCL DDX46 APP SAP30BP	2.04e-05	278	25	5	int:NSD2
Interaction	YAP1 interactions	NEFM TPR NCL DDX46 CTNND1 EPB41L2 SAP30BP SUPT16H	3.49e-05	1095	25	8	int:YAP1
Interaction	ITGB3 interactions	TPR NCL APP PECAM1	5.38e-05	170	25	4	int:ITGB3
Interaction	ZNF181 interactions	DDX46 APP	6.61e-05	10	25	2	int:ZNF181
Interaction	STXBP1 interactions	NEFM STX4 APP UNC13A	8.46e-05	191	25	4	int:STXBP1
Interaction	TNIK interactions	NEFM TPR CTNND1 UNC13A SUPT16H	9.15e-05	381	25	5	int:TNIK
Interaction	UHRF2 interactions	TPR SGO2 NCL SUPT16H	1.01e-04	200	25	4	int:UHRF2
Interaction	ALOX5 interactions	RAB3GAP1 ARMCX5 APP	1.03e-04	74	25	3	int:ALOX5
Interaction	ITGB1 interactions	TPR NCL STX4 APP SUPT16H	1.15e-04	400	25	5	int:ITGB1
Interaction	NAA40 interactions	TPR NCL DDX46 CTNND1 EPB41L2 SAP30BP SUPT16H	1.38e-04	978	25	7	int:NAA40
Cytoband	2q37.1	NCL SAG	6.16e-04	67	25	2	2q37.1
Cytoband	17q25.1	CASKIN2 SAP30BP	8.98e-04	81	25	2	17q25.1
Cytoband	Ensembl 112 genes in cytogenetic band chr2q37	NCL SAG	6.72e-03	226	25	2	chr2q37
Cytoband	Ensembl 112 genes in cytogenetic band chr17q25	CASKIN2 SAP30BP	1.21e-02	307	25	2	chr17q25
GeneFamily	DEAD-box helicases	DDX46 DDX60	9.75e-04	42	20	2	499
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	ARMCX5 CTNND1	1.02e-03	43	20	2	409
Coexpression	GSE40666_UNTREATED_VS_IFNA_STIM_STAT1_KO_CD8_TCELL_90MIN_DN	CTNND1 APP EPB41L2 PECAM1	3.53e-05	198	25	4	M9234
Coexpression	HALLMARK_APICAL_JUNCTION	STX4 CTNND1 EPB41L2 PECAM1	3.67e-05	200	25	4	M5915
CoexpressionAtlas	FacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_500_k-means-cluster#5	TPR SGO2 NCL DDX46	6.24e-05	186	25	4	Facebase_RNAseq_e10.5_Mandibular Arch_500_K5
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500_k-means-cluster#3	NEFM NCL DDX46 SUPT16H	7.06e-05	192	25	4	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500_K3
ToppCell	Myeloid-Myeloid-B_(Activated_Macrophage)\|Myeloid / shred on cell class and cell subclass (v4)	NCL DDX46 CTNND1 APP EPB41L2	6.49e-08	191	25	5	7bf125249af1e8bb138ed4d999fdd74b03ab2447
ToppCell	Control_saline-Endothelial-Endothelial-Activated_Alv_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 DDX60 PECAM1	8.16e-08	200	25	5	be55cef682ba87250dad97689332c8820b3a7420
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 DDX60 PECAM1	8.16e-08	200	25	5	89821a264e872ed53e08e9d3609d5cc5c314503e
ToppCell	Control-Endothelial_cells-Inflamed_endothelial_cells\|Control / group, cell type (main and fine annotations)	APP CASKIN2 EPB41L2 PECAM1	1.84e-06	160	25	4	958256e3d3836160763b82bb48f794087918d935
ToppCell	Control-Endothelial_cells-Capillary_endothelial_cells\|Control / group, cell type (main and fine annotations)	APP CASKIN2 EPB41L2 PECAM1	2.93e-06	180	25	4	b043f9ffb9a4cd427a15bebb86a711c7b08866e8
ToppCell	Control-Endothelial-VE_Capillary_A\|World / Disease state, Lineage and Cell class	APP CASKIN2 EPB41L2 PECAM1	3.27e-06	185	25	4	a28187c2fd23564314b35759479ff2ca21f61485
ToppCell	Control-Endothelial-VE_Capillary_A\|Control / Disease state, Lineage and Cell class	APP CASKIN2 EPB41L2 PECAM1	3.41e-06	187	25	4	54d7588172ac145ff5045ad9771636729ca3f0ca
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Adult / Lineage, Cell type, age group and donor	APP CASKIN2 EPB41L2 PECAM1	3.49e-06	188	25	4	e5cad03f4a64147fe8174e7f614cf45233ffb9b7
ToppCell	Control-Endothelial_cells\|Control / group, cell type (main and fine annotations)	APP CASKIN2 EPB41L2 PECAM1	3.49e-06	188	25	4	3953b08abfea93468fc8d177bdb16ca7c6ffa1ab
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	APP CASKIN2 EPB41L2 PECAM1	3.56e-06	189	25	4	b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	APP CASKIN2 EPB41L2 PECAM1	3.64e-06	190	25	4	0a351609a72fd638c84b2435782e312ee6a33aac
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	APP CASKIN2 EPB41L2 PECAM1	3.64e-06	190	25	4	0e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	APP CASKIN2 EPB41L2 PECAM1	3.71e-06	191	25	4	f229abf69a1217194f74b0502486907e07dba989
ToppCell	Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|World / Lineage, Cell type, age group and donor	APP CASKIN2 EPB41L2 PECAM1	3.79e-06	192	25	4	1e156bab5ecf64627890d2de9b27603d9a01f28d
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	APP CASKIN2 EPB41L2 PECAM1	3.87e-06	193	25	4	f582e939e3e08a8a3f71deec78c33715be8faa51
ToppCell	nucseq-Endothelial-Endothelial_Vascular\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	APP CASKIN2 EPB41L2 PECAM1	4.11e-06	196	25	4	686533fd3fba8e4df96b9dd1307e870e89db4332
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	APP CASKIN2 EPB41L2 PECAM1	4.11e-06	196	25	4	a53caedd0103bd162b3aee8ab87b4442a5e0338f
ToppCell	Endothelial\|World / Lineage, Cell type, age group and donor	APP CASKIN2 EPB41L2 PECAM1	4.11e-06	196	25	4	96c6d78482a130ce4e29f6629972a06d10d7530e
ToppCell	nucseq-Endothelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	APP CASKIN2 EPB41L2 PECAM1	4.20e-06	197	25	4	ebf9be068eaa658493fa7884fd19f34642922acb
ToppCell	cellseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	APP CASKIN2 EPB41L2 PECAM1	4.37e-06	199	25	4	9364199c5b4540ce2e14341fd9d504b695f8249d
ToppCell	distal-Endothelial-Capillary_Intermediate_2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	APP CASKIN2 EPB41L2 PECAM1	4.37e-06	199	25	4	b44712baede833ddbac3699162b7eeb6ede2af27
ToppCell	distal-Endothelial-Capillary_Intermediate_2-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	APP CASKIN2 EPB41L2 PECAM1	4.37e-06	199	25	4	a5c2c676fc0dd4f0422fbcae34ad6d734edd5349
ToppCell	Parenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	APP CASKIN2 EPB41L2 PECAM1	4.37e-06	199	25	4	dc88ce36cc066eb6c28cfd5b9b60fe07f8cc7b53
ToppCell	Tracheal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	APP CASKIN2 EPB41L2 PECAM1	4.37e-06	199	25	4	1621ce2968f3100e4c39e0ef8293232a5d76c614
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	APP CASKIN2 EPB41L2 PECAM1	4.37e-06	199	25	4	6cfe5a3d0ad530411ebc11decb4ab4c529e018d5
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	b7533c571eeea0cb3678e1a57d3dc036fa8d0f49
ToppCell	Parenchymal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	APP CASKIN2 EPB41L2 PECAM1	4.46e-06	200	25	4	3653002c805c314043e2a7b0c9980dfe952dc53e
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	a1fa6bae5a688faf488d6925cd3fad725dfa916b
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	APP CASKIN2 EPB41L2 PECAM1	4.46e-06	200	25	4	3767abc75176779198505ebc6967d55ce322d9fe
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	89a6da2bdedc6b1ad0675c8753bf2b763a99af6a
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	b70b7adb7c187e6253c7f0bb4c1f09c85ef7142c
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	APP CASKIN2 EPB41L2 PECAM1	4.46e-06	200	25	4	e0a003d2a5fd6adfcb817c9bc5dceb9c79e7491b
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	bcd1cc96197929d6011903803b6f4ccdcf52b4ce
ToppCell	LPS_anti-TNF-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	1d105eeda5a2c51f9a4654ffc79b7e2348ad593b
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	6f531a418ff25b59a543800cf4bce7b72404ce08
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	58a7ece7dfdf6c46f2a50cbcb580574dec14c748
ToppCell	LPS_IL1RA_TNF-Endothelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	d01cec331be3b03cef80e9536fc531285bcf00f6
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCell	LPS_anti-TNF-Endothelial-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	60d2cbf41f37f1b11eddb4c9d9246c9c1fc5a5af
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	432384faeade8e609154fab3d96c955a8ec868dd
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	Control_saline-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	3372c488a39fe812fa94e4f0564594186fea3db5
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	3585484c7e24e941708bee471ca607d8ccee74e6
ToppCell	LPS_only-Endothelial\|LPS_only / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	81e76508c9050d533853d5fd2f3097b27613d836
ToppCell	Control_saline-Endothelial-Endothelial-Alv_Gen_Intermediate\|Control_saline / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	041a34080120c9f613373c20dcc366292f558040
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_only / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	b1fadb2b5e37e0f51e079d8409c2647eef68dc3b
ToppCell	Control_saline-Endothelial-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	4bb609a284d4e6066f17470a1736076aa4a1f84c
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CTNND1 APP CASKIN2 PECAM1	4.46e-06	200	25	4	f15fffefe372005c33e31845982e2d2714ac26af
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEFM SGO2 STX4	9.06e-05	157	25	3	370f44047ef438b8f1124c2c2761c150c0d8c57f
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_macrophage-microglial_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SAG CTNND1 EPB41L2	9.41e-05	159	25	3	31ec8222c766cb614e1cf27f74ee9d99489eca5c
ToppCell	normal_Lung-Myeloid_cells-Undetermined\|Myeloid_cells / Location, Cell class and cell subclass	SDR16C5 CASKIN2 TGFA	9.76e-05	161	25	3	283012858e575c70d09950de53da041509f59bfa
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	APP CASKIN2 PECAM1	1.07e-04	166	25	3	76b4cd32698900797ec009f17e50ea7ae36b85f4
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|368C / Donor, Lineage, Cell class and subclass (all cells)	APP CASKIN2 PECAM1	1.07e-04	166	25	3	30a991fc3275b571d53bd0976df4789e5d40b01d
ToppCell	390C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|390C / Donor, Lineage, Cell class and subclass (all cells)	APP CASKIN2 PECAM1	1.19e-04	172	25	3	6f302ed795767a9636081dc64373f8f039ea16d2
ToppCell	390C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	APP CASKIN2 PECAM1	1.19e-04	172	25	3	fd8097299fc05390b30afaa9e6c80b1f607c27aa
ToppCell	390C-Endothelial_cells-Endothelial-E-\|390C / Donor, Lineage, Cell class and subclass (all cells)	APP CASKIN2 PECAM1	1.31e-04	178	25	3	804ac3725c1f88e2212172bfb9aa01d97a735621
ToppCell	390C-Endothelial_cells-Endothelial-E\|390C / Donor, Lineage, Cell class and subclass (all cells)	APP CASKIN2 PECAM1	1.31e-04	178	25	3	ad6dc4a375664c919bd48c35c48a561fc5a7de8c
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SGO2 CASKIN2 PECAM1	1.31e-04	178	25	3	ea10117026021c959ffc871fc377cdb3e161d264
ToppCell	367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|367C / Donor, Lineage, Cell class and subclass (all cells)	APP CASKIN2 PECAM1	1.36e-04	180	25	3	162cec1734e560c068cd61717e40e18dcf92308c
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	APP CASKIN2 PECAM1	1.36e-04	180	25	3	d8ef44710a77ad0fc03243428e5e1dc4d41200cb
ToppCell	367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	APP CASKIN2 PECAM1	1.36e-04	180	25	3	33c86c22ba877358cd8c1e39b5c0b3dc3a45b7dd
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	APP CASKIN2 PECAM1	1.36e-04	180	25	3	544fb373a3346186ec60afe2cfcf141bb04a1eed
ToppCell	COVID-19-Endothelial_cells-Capillary_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	APP CASKIN2 PECAM1	1.38e-04	181	25	3	c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-OPC\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GALR1 DDX60 TGFA	1.40e-04	182	25	3	831b5ce46b41efe01c4db6016c2f43148611373d
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	APP EPB41L2 PECAM1	1.40e-04	182	25	3	a20017b6a4f9a6a29e090e4dbd7c02ed1495bd50
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEFM GALR1 UNC13A	1.40e-04	182	25	3	398ce074a04f6482470b488f1affae4af7d2ec58
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D175\|Adult / Lineage, Cell type, age group and donor	CASKIN2 EPB41L2 PECAM1	1.40e-04	182	25	3	8b4a07ebd7a133a33ef333cfa29d12c4f3d4d9ac
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GALR1 DDX60 TGFA	1.40e-04	182	25	3	a05e5978ef5f7fac7eeb2ba1c0103ea90d5e9136
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEFM GALR1 UNC13A	1.43e-04	183	25	3	d26c7b79895de28961b8d68351f28d4bb531c75c
ToppCell	PCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NEFM GALR1 UNC13A	1.45e-04	184	25	3	571136c832cb8c08457744152231537aa8e8abd7
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEFM GALR1 UNC13A	1.45e-04	184	25	3	3da93e7d8b62463e307cc0425c47dbd3bef66799
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GALR1 DDX60 TGFA	1.47e-04	185	25	3	efc5d564f8793c751ba640aef60f761e4b081d3f
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-OPC\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GALR1 DDX60 TGFA	1.47e-04	185	25	3	fba2dc46cd98ab9c78e788959c2121aa10d148b2
ToppCell	COVID-CD4-CD8_1\|COVID / Condition, Cell_class and T cell subcluster	SGO2 SLC9A3 ARMCX5	1.47e-04	185	25	3	c634bb04a081ae3214b68f6e4a147db5b2b916ed
ToppCell	Control-Endothelial_cells-Endothelial_cells_(other)\|Control / group, cell type (main and fine annotations)	APP CASKIN2 PECAM1	1.50e-04	186	25	3	c6075fe84226b370c5139066793844ad33ae2db1
ToppCell	PCW_07-8.5-Neuronal-Neuronal_postreplicative\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NEFM GALR1 UNC13A	1.50e-04	186	25	3	2fdd0a80ad31cf017aafcf5dcf760ebd786b98c1
ToppCell	356C-Endothelial_cells-Endothelial-E-\|356C / Donor, Lineage, Cell class and subclass (all cells)	APP CASKIN2 PECAM1	1.50e-04	186	25	3	2e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell	356C-Endothelial_cells-Endothelial-E\|356C / Donor, Lineage, Cell class and subclass (all cells)	APP CASKIN2 PECAM1	1.50e-04	186	25	3	c3449e54454009973818fc1101933c6f0168258c
ToppCell	356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	APP CASKIN2 PECAM1	1.50e-04	186	25	3	f0b78c7ee20279970ea8961bf59acb5262f2dce5
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	TPR RAB3GAP1 DDX46	1.50e-04	186	25	3	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|356C / Donor, Lineage, Cell class and subclass (all cells)	APP CASKIN2 PECAM1	1.50e-04	186	25	3	2b3c814a7dee8286ea113c63dc3de5daf0257d37
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	APP CASKIN2 PECAM1	1.52e-04	187	25	3	97b2463fb37e7196dd2f92553acf8e7bc3ec40dd
ToppCell	Control-Endothelial_cells-Endothelial_cells_(general)\|Control / group, cell type (main and fine annotations)	APP CASKIN2 PECAM1	1.52e-04	187	25	3	fb5bcbc8effdbf0e57fcb71aca990a4aa0d65ce8
ToppCell	343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	APP CASKIN2 PECAM1	1.54e-04	188	25	3	fe7143c36e4a883745862d3c3147cf751b440e46
ToppCell	343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|343B / Donor, Lineage, Cell class and subclass (all cells)	APP CASKIN2 PECAM1	1.54e-04	188	25	3	cbf32b675a7cd0c808d5c9c22dfa7fa79fbe2437
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NCL EPB41L2 PECAM1	1.59e-04	190	25	3	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CTNND1 CASKIN2 PECAM1	1.59e-04	190	25	3	474cbbab8f3b0a6881fa6c92edb78e43999f9ab0
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	APP CASKIN2 PECAM1	1.62e-04	191	25	3	1de0bdfd13bd930691564c2673f2e66393bc0255
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CASKIN2 DDX60 PECAM1	1.64e-04	192	25	3	c618ede75dce3988c87a5b8f98d8e94e1dd66efd
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APP EPB41L2 PECAM1	1.64e-04	192	25	3	6806a1a9fe00395dc1abc3e0124b4261dc701f31
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	APP CASKIN2 PECAM1	1.64e-04	192	25	3	7197e401e563441ab94815f7619e032ebef9e586
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APP EPB41L2 PECAM1	1.64e-04	192	25	3	d525f7f088a53110912600a7c9f6d33b9270d534
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APP EPB41L2 PECAM1	1.64e-04	192	25	3	2bfac6b3956265205ca47d06888851ed68b65999
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CTNND1 CASKIN2 PECAM1	1.67e-04	193	25	3	a3636c35ed25aabe2f1aba016c9fe125327bbfaf
ToppCell	facs-Liver-Non-hepatocytes-3m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APP EPB41L2 PECAM1	1.67e-04	193	25	3	8084fa0ce61f1f4a728423b6b81df04eaa5af5b6
Drug	4-hydroxy-equilenin	NCL PECAM1 TGFA	2.33e-05	53	24	3	ctd:C065250
Drug	AC1L1DW2	NEFM STX4 CTNND1 PECAM1	4.03e-05	186	24	4	CID000002532
Drug	1,2-diethylbenzene	NEFM APP	4.77e-05	10	24	2	CID000008657
Drug	1,2-diacetylbenzene	NEFM APP	4.77e-05	10	24	2	CID000035459
Drug	Pridinol methanesulfonate salt [6856-31-1]; Down 200; 10.2uM; PC3; HT_HG-U133A	TPR APP CASKIN2 EPB41L2	4.95e-05	196	24	4	5860_DN
Drug	Sulfamethoxazole [723-46-6]; Down 200; 15.8uM; PC3; HT_HG-U133A	TPR RAB3GAP1 APP CASKIN2	5.14e-05	198	24	4	7366_DN
Disease	osteoarthritis, hip, osteoarthritis, knee	ZC3H11B TGFA	1.16e-03	62	24	2	EFO_0004616, EFO_1000786
Disease	Nerve Degeneration	APP TGFA	2.07e-03	83	24	2	C0027746
Disease	Back pain	MKX TGFA	2.27e-03	87	24	2	HP_0003418
Disease	osteoarthritis, hip	ZC3H11B TGFA	2.54e-03	92	24	2	EFO_1000786
Disease	acne	ZC3H11B TGFA	4.62e-03	125	24	2	EFO_0003894
Disease	Alzheimer's disease (is_implicated_in)	NEFM APP	5.14e-03	132	24	2	DOID:10652 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
VTVQVGKTKKRTKTI	UNC13A	701	Q9UPW8
VIATVIVITLVMLKK	APP	711	P05067
VTVTVTNNTEKTVKK	SAG	226	P10523
VSTVTKSEVKVVAVI	ARMCX5	116	Q6P1M9
ISSVKKIIKQIISHS	RAB3GAP1	801	Q15042
VETFVQKQKGIKTTI	SDR16C5	206	Q8N3Y7
LETVSSKIIVTQTIK	DDX60	546	Q8IY21
VTKKTKTVQCKVTLL	EPB41L2	211	O43491
IIQKSSHIAEVKTVK	MKX	331	Q8IYA7
DKVVKKSNTVQIVVC	PECAM1	391	P16284
VTGVQKLVAKVKATK	CASKIN2	16	Q8WXE0
AKKVVVSPTKKVAVA	NCL	61	P19338
SKKKTAQTVLVVVVV	GALR1	241	P47211
VTKVVTVVTTKKAVV	DDX46	261	Q7L014
VKKVVKTVTTRTVQP	CTNND1	141	O60716
VKEKNLFVSTTIIVV	SLC9A3	431	P48764
EVSKIVTVSTGIKKK	SGO2	371	Q562F6
KKKVLIAICVSITVV	STX4	271	Q12846
TVLTSVKKKVKNVGI	SUPT16H	416	Q9Y5B9
KKQAITALVVVSIVA	TGFA	96	P01135
IIDIQEKVKTITQVK	TPR	1421	P12270
SKTTVISAVGTIVKK	SAP30BP	291	Q9UHR5
VNVKQSVVKVVSSPK	ZC3H11B	651	A0A1B0GTU1
HSKKTVKKVVVVEQN	ZNF740	76	Q8NDX6
VVTITKSVKVHLEKE	NEFM	746	P07197