Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF93 ZNF567 ZNF486 HDAC6 RBBP4 ZNF273 ZNF722 ZNF302 ZNF626 STAT2 ZNF430 ZNF716 ZNF100 ZSCAN21 ZNF257 ZNF253 ZNF735 ZNF737 ZNF506 ZNF479 NR5A1 ZNF90 ZNF679	9.66e-06	1244	135	23	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF93 ZNF567 ZNF486 HDAC6 RBBP4 ZNF273 ZNF722 ZNF302 ZNF626 STAT2 ZNF430 ZNF716 ZNF100 ZSCAN21 ZNF257 ZNF253 ZNF735 ZNF737 ZNF506 ZNF479 NR5A1 ZNF90 ZNF679	1.37e-05	1271	135	23	GO:0000987
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF93 ZNF567 ZNF486 HDAC6 RBBP4 ZNF273 ZNF722 ZNF302 ZNF626 STAT2 ZNF430 ZNF716 ZNF100 ZSCAN21 EHMT2 ZNF257 ZNF253 ZNF735 ZNF737 ZNF506 ZNF479 NR5A1 ZFP69B ZNF90 ZNF679	1.39e-05	1459	135	25	GO:0000977
GeneOntologyMolecularFunction	transmembrane receptor protein serine/threonine kinase activity	ACVR2A ACVR2B LTBP1	3.17e-04	20	135	3	GO:0004675
GeneOntologyMolecularFunction	inhibin binding	ACVR2A ACVR2B	4.48e-04	5	135	2	GO:0034711
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF93 ZNF486 ZNF273 ZNF722 ZNF302 ZNF626 STAT2 ZNF430 ZNF716 ZNF100 ZSCAN21 ZNF257 ZNF253 ZNF735 ZNF737 ZNF506 ZNF479 NR5A1 ZFP69B ZNF90 ZNF679	5.16e-04	1412	135	21	GO:0000981
GeneOntologyMolecularFunction	histone H3K27 methyltransferase activity	EHMT2 EHMT1	6.69e-04	6	135	2	GO:0046976
GeneOntologyMolecularFunction	transcription corepressor binding	HDAC6 PHF12 EHMT2 EHMT1	6.82e-04	59	135	4	GO:0001222
GeneOntologyCellularComponent	nuclear pore inner ring	NUP155 NUP188	1.22e-04	3	134	2	GO:0044611
Domain	KRAB	ZNF93 ZNF567 ZNF486 ZNF273 ZNF302 ZNF626 ZNF430 ZNF716 ZNF100 ZNF257 ZNF253 ZNF735 ZNF737 ZNF506 ZNF479 ZFP69B ZNF90 ZNF679	7.51e-11	358	132	18	PS50805
Domain	KRAB	ZNF93 ZNF567 ZNF486 ZNF273 ZNF302 ZNF626 ZNF430 ZNF716 ZNF100 ZNF257 ZNF253 ZNF735 ZNF737 ZNF506 ZNF479 ZFP69B ZNF90 ZNF679	7.51e-11	358	132	18	PF01352
Domain	KRAB	ZNF93 ZNF567 ZNF486 ZNF273 ZNF302 ZNF626 ZNF430 ZNF716 ZNF100 ZNF257 ZNF253 ZNF735 ZNF737 ZNF506 ZNF479 ZFP69B ZNF90 ZNF679	1.23e-10	369	132	18	SM00349
Domain	KRAB	ZNF93 ZNF567 ZNF486 ZNF273 ZNF302 ZNF626 ZNF430 ZNF716 ZNF100 ZNF257 ZNF253 ZNF735 ZNF737 ZNF506 ZNF479 ZFP69B ZNF90 ZNF679	1.29e-10	370	132	18	IPR001909
Domain	PH_BEACH	NBEA LYST WDFY3 LRBA	3.54e-08	6	132	4	PF14844
Domain	zf-C2H2_6	ZNF93 ZNF567 ZNF486 ZNF273 ZNF302 ZNF626 ZNF100 ZNF253 ZNF735 ZNF737 ZNF506 ZNF479 ZFP69B ZNF90	4.98e-08	314	132	14	PF13912
Domain	PH-BEACH_dom	NBEA LYST WDFY3 LRBA	1.63e-07	8	132	4	IPR023362
Domain	-	NBEA LYST WDFY3 LRBA	1.63e-07	8	132	4	2.30.29.40
Domain	PH_BEACH	NBEA LYST WDFY3 LRBA	1.63e-07	8	132	4	PS51783
Domain	BEACH	NBEA LYST WDFY3 LRBA	2.92e-07	9	132	4	PS50197
Domain	Beach	NBEA LYST WDFY3 LRBA	2.92e-07	9	132	4	PF02138
Domain	-	NBEA LYST WDFY3 LRBA	2.92e-07	9	132	4	1.10.1540.10
Domain	Beach	NBEA LYST WDFY3 LRBA	2.92e-07	9	132	4	SM01026
Domain	BEACH_dom	NBEA LYST WDFY3 LRBA	2.92e-07	9	132	4	IPR000409
Domain	-	ZNF93 ZNF567 ZNF486 ZNF273 ZNF302 ZNF626 ZNF430 ZNF716 ZNF100 ZSCAN21 ZNF257 ZNF253 ZNF735 ZNF737 ZNF506 ZNF479 ZFP69B ZNF90 ZNF679	3.06e-07	679	132	19	3.30.160.60
Domain	zf-C2H2	ZNF93 ZNF567 ZNF486 ZNF273 ZNF302 ZNF626 ZNF430 ZNF716 ZNF100 ZSCAN21 ZNF257 ZNF253 ZNF735 ZNF737 ZNF506 ZNF479 ZFP69B ZNF90 ZNF679	4.18e-07	693	132	19	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF93 ZNF567 ZNF486 ZNF273 ZNF302 ZNF626 ZNF430 ZNF716 ZNF100 ZSCAN21 ZNF257 ZNF253 ZNF735 ZNF737 ZNF506 ZNF479 ZFP69B ZNF90 ZNF679	4.27e-07	694	132	19	IPR013087
Domain	WD40_repeat	WSB1 RBBP4 VPS8 NBEA CORO1B LYST DENND3 WRAP73 CORO6 WDFY3 LRBA WDR62	5.29e-07	272	132	12	IPR001680
Domain	WD_REPEATS_1	WSB1 RBBP4 VPS8 NBEA CORO1B LYST DENND3 WRAP73 CORO6 WDFY3 LRBA WDR62	6.67e-07	278	132	12	PS00678
Domain	WD_REPEATS_2	WSB1 RBBP4 VPS8 NBEA CORO1B LYST DENND3 WRAP73 CORO6 WDFY3 LRBA WDR62	6.93e-07	279	132	12	PS50082
Domain	WD_REPEATS_REGION	WSB1 RBBP4 VPS8 NBEA CORO1B LYST DENND3 WRAP73 CORO6 WDFY3 LRBA WDR62	6.93e-07	279	132	12	PS50294
Domain	-	WSB1 RBBP4 VPS8 NBEA CORO1B LYST DENND3 PLXNC1 WRAP73 CORO6 WDFY3 LRBA WDR62	6.99e-07	333	132	13	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	WSB1 RBBP4 VPS8 NBEA CORO1B LYST DENND3 PLXNC1 WRAP73 CORO6 WDFY3 LRBA WDR62	7.47e-07	335	132	13	IPR015943
Domain	ZINC_FINGER_C2H2_2	ZNF93 ZNF567 ZNF486 ZNF273 ZNF302 ZNF626 ZNF430 ZNF716 ZNF100 ZSCAN21 ZNF257 ZNF253 ZNF735 ZNF737 ZNF506 ZNF479 ZFP69B ZNF90 ZNF679	2.21e-06	775	132	19	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF93 ZNF567 ZNF486 ZNF273 ZNF302 ZNF626 ZNF430 ZNF716 ZNF100 ZSCAN21 ZNF257 ZNF253 ZNF735 ZNF737 ZNF506 ZNF479 ZFP69B ZNF90 ZNF679	2.30e-06	777	132	19	PS00028
Domain	WD40	WSB1 RBBP4 NBEA CORO1B LYST DENND3 WRAP73 CORO6 WDFY3 LRBA WDR62	2.33e-06	259	132	11	PF00400
Domain	WD40	WSB1 RBBP4 NBEA CORO1B LYST DENND3 WRAP73 CORO6 WDFY3 LRBA WDR62	3.23e-06	268	132	11	SM00320
Domain	Znf_C2H2-like	ZNF93 ZNF567 ZNF486 ZNF273 ZNF302 ZNF626 ZNF430 ZNF716 ZNF100 ZSCAN21 ZNF257 ZNF253 ZNF735 ZNF737 ZNF506 ZNF479 ZFP69B ZNF90 ZNF679	3.27e-06	796	132	19	IPR015880
Domain	DUF4704	NBEA WDFY3 LRBA	3.42e-06	5	132	3	IPR031570
Domain	DUF4704	NBEA WDFY3 LRBA	3.42e-06	5	132	3	PF15787
Domain	Znf_C2H2	ZNF93 ZNF567 ZNF486 ZNF273 ZNF302 ZNF626 ZNF430 ZNF716 ZNF100 ZSCAN21 ZNF257 ZNF253 ZNF735 ZNF737 ZNF506 ZNF479 ZFP69B ZNF90 ZNF679	3.85e-06	805	132	19	IPR007087
Domain	ZnF_C2H2	ZNF93 ZNF567 ZNF486 ZNF273 ZNF302 ZNF626 ZNF430 ZNF716 ZNF100 ZSCAN21 ZNF257 ZNF253 ZNF735 ZNF737 ZNF506 ZNF479 ZFP69B ZNF90 ZNF679	4.06e-06	808	132	19	SM00355
Domain	WD40_repeat_dom	WSB1 RBBP4 VPS8 NBEA CORO1B LYST DENND3 CORO6 WDFY3 LRBA WDR62	8.60e-06	297	132	11	IPR017986
Domain	ARM-type_fold	USP34 IPO7 TNPO2 NBEA LYST KPNA7 SERAC1 NUP188 WDFY3 LRBA HECTD1	2.94e-05	339	132	11	IPR016024
Domain	DUF1088	NBEA LRBA	4.96e-05	2	132	2	IPR010508
Domain	DUF1088	NBEA LRBA	4.96e-05	2	132	2	PF06469
Domain	WD40_repeat_CS	WSB1 RBBP4 CORO1B LYST DENND3 CORO6 WDFY3	1.66e-04	164	132	7	IPR019775
Domain	Apc4_WD40_dom	WRAP73 CORO6 WDR62	3.60e-04	20	132	3	IPR024977
Domain	ANAPC4_WD40	WRAP73 CORO6 WDR62	3.60e-04	20	132	3	PF12894
Domain	HEMATOPO_REC_S_F2	IL13RA1 IL3RA	4.89e-04	5	132	2	PS01356
Domain	Short_hematopoietin_rcpt_2_CS	IL13RA1 IL3RA	4.89e-04	5	132	2	IPR003532
Domain	ACTININ_2	SYNE1 PLEC UTRN	5.51e-04	23	132	3	PS00020
Domain	ACTININ_1	SYNE1 PLEC UTRN	5.51e-04	23	132	3	PS00019
Domain	Actinin_actin-bd_CS	SYNE1 PLEC UTRN	5.51e-04	23	132	3	IPR001589
Domain	-	CLGN CNTNAP1 NBEA WDFY3 LRBA	5.69e-04	95	132	5	2.60.120.200
Domain	ARM-like	IPO7 TNPO2 NBEA KPNA7 SERAC1 WDFY3 LRBA HECTD1	6.76e-04	270	132	8	IPR011989
Domain	HECT	HERC3 HERC6 HECTD1	8.91e-04	27	132	3	PF00632
Domain	HECTc	HERC3 HERC6 HECTD1	8.91e-04	27	132	3	SM00119
Domain	HECT_dom	HERC3 HERC6 HECTD1	8.91e-04	27	132	3	IPR000569
Domain	HECT	HERC3 HERC6 HECTD1	8.91e-04	27	132	3	PS50237
Domain	Pre-SET	EHMT2 EHMT1	1.02e-03	7	132	2	PF05033
Domain	Trimer_CC	CORO1B CORO6	1.02e-03	7	132	2	IPR015049
Domain	DUF1899	CORO1B CORO6	1.02e-03	7	132	2	IPR015048
Domain	Trimer_CC	CORO1B CORO6	1.02e-03	7	132	2	PF08954
Domain	DUF1899	CORO1B CORO6	1.02e-03	7	132	2	PF08953
Domain	PreSET	EHMT2 EHMT1	1.02e-03	7	132	2	SM00468
Domain	Coronin	CORO1B CORO6	1.02e-03	7	132	2	IPR015505
Domain	DUF1899	CORO1B CORO6	1.02e-03	7	132	2	SM01166
Domain	Pre-SET_dom	EHMT2 EHMT1	1.02e-03	7	132	2	IPR007728
Domain	PRE_SET	EHMT2 EHMT1	1.02e-03	7	132	2	PS50867
Domain	-	IPO7 TNPO2 KPNA7 SERAC1 WDFY3 LRBA HECTD1	1.02e-03	222	132	7	1.25.10.10
Domain	Spectrin_repeat	SYNE1 PLEC UTRN	1.10e-03	29	132	3	IPR002017
Domain	CH	SYNE1 LRCH1 PLEC UTRN	1.16e-03	65	132	4	SM00033
Domain	SPEC	SYNE1 PLEC UTRN	1.47e-03	32	132	3	SM00150
Domain	Spectrin/alpha-actinin	SYNE1 PLEC UTRN	1.47e-03	32	132	3	IPR018159
Domain	CH	SYNE1 LRCH1 PLEC UTRN	1.52e-03	70	132	4	PF00307
Domain	-	SYNE1 LRCH1 PLEC UTRN	1.61e-03	71	132	4	1.10.418.10
Domain	CH	SYNE1 LRCH1 PLEC UTRN	1.78e-03	73	132	4	PS50021
Domain	CH-domain	SYNE1 LRCH1 PLEC UTRN	1.97e-03	75	132	4	IPR001715
Domain	Activin_recp	ACVR2A ACVR2B	2.15e-03	10	132	2	PF01064
Domain	Activin_recp	ACVR2A ACVR2B	2.15e-03	10	132	2	IPR000472
Domain	IL6Ra-bind	IL13RA1 IL3RA	2.62e-03	11	132	2	PF09240
Domain	TypeI_recpt_CBD	IL13RA1 IL3RA	2.62e-03	11	132	2	IPR015321
Domain	TGFB_receptor	ACVR2A ACVR2B	3.12e-03	12	132	2	IPR000333
Domain	Kelch_2	KLHDC1 KLHL36	3.67e-03	13	132	2	IPR011498
Domain	Kelch_2	KLHDC1 KLHL36	3.67e-03	13	132	2	PF07646
Domain	IMPORTIN_B_NT	IPO7 TNPO2	4.27e-03	14	132	2	PS50166
Domain	Diacylglycerol_kinase_cat_dom	CERKL DGKA	4.90e-03	15	132	2	IPR001206
Domain	START_lipid-bd_dom	CERT1 ACOT12	4.90e-03	15	132	2	IPR002913
Domain	DAGK	CERKL DGKA	4.90e-03	15	132	2	PS50146
Domain	N2O_reductase_N	VPS8 CORO1B	4.90e-03	15	132	2	IPR011045
Domain	START	CERT1 ACOT12	4.90e-03	15	132	2	PF01852
Domain	IBN_N	IPO7 TNPO2	4.90e-03	15	132	2	PF03810
Domain	DAGK_cat	CERKL DGKA	4.90e-03	15	132	2	PF00781
Domain	START	CERT1 ACOT12	4.90e-03	15	132	2	PS50848
Domain	IBN_N	IPO7 TNPO2	5.58e-03	16	132	2	SM00913
Domain	Ank	ASAP3 ANKRD62 EHMT2 ASB5 EHMT1 HECTD1	5.67e-03	228	132	6	PF00023
Domain	NAD/diacylglycerol_kinase	CERKL DGKA	6.29e-03	17	132	2	IPR016064
Domain	Importin-beta_N	IPO7 TNPO2	6.29e-03	17	132	2	IPR001494
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF567 ZNF486 HDAC6 RBBP4 ZNF273 RET ZNF302 ZNF626 ZNF430 ZNF716 ZNF100 EHMT2 ANAPC1 ZNF257 ZNF253 ZNF735 EHMT1 ZNF737 ZNF506 ZNF479 INTS9 NR5A1 ZFP69B ZNF679	1.12e-05	1387	95	24	M734
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF93 ZNF567 ZNF486 RMND5A ZNF273 ZNF626 ZNF430 ZNF100 EHMT2 ZNF257 ZNF253 EHMT1 ZNF737 ZNF90	1.57e-14	181	136	14	37372979
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF93 ZNF626 ZNF716 ZNF506 ZNF679	9.35e-08	29	136	5	14563677
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	USP34 RMND5A IPO7 RBBP4 CORO1B MDN1 EHMT2 ANAPC1 POP1 INTS9	1.81e-07	282	136	10	23667531
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	USP34 FLII TMEM120B TMEM94 PHF12 CORO1B NPHP4 LYST CNPPD1 MDN1 KLHL36 EHMT1 LRP3 NUP188 WDFY3 PLEC LRBA HECTD1	3.39e-07	1105	136	18	35748872
Pubmed	Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.	ZNF93 ZNF100 ZNF737 ZNF90	3.93e-07	16	136	4	8467795
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP34 IPO7 RBBP4 MDN1 NUP155 CCT5 ANAPC1 POP1 NUP188 PLEC HECTD1 UTRN USP47	1.88e-06	653	136	13	22586326
Pubmed	Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J.	ZNF626 ZNF716 ZNF506 CD180 ZNF679	2.52e-06	55	136	5	29997285
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	USP34 FLII HDAC6 TNPO2 SYNE1 CNTNAP1 NBEA ZNF302 ARG2 CNPPD1 EHMT2 DENND6B WDFY3 PLEC LRBA HECTD1 UTRN USP47	2.89e-06	1285	136	18	35914814
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TOR1AIP2 USP34 ZNF93 HDAC6 RAPGEF5 DGKA ACVR2A KIAA0753 MTMR6 TCP11L2 ZSCAN21 EXOC3L4 POP1 NUP188 PLEC UTRN	5.61e-06	1084	136	16	11544199
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	HDAC6 CNTNAP1 PCDHA11 PCDHA10 NBEA EHMT2 NR5A1 LRBA IL3RA	6.36e-06	329	136	9	17474147
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	RBBP4 NBEA LRCH1 MDN1 ANAPC1 LRBA	1.23e-05	129	136	6	23022380
Pubmed	Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance.	EHMT2 EHMT1 NR5A1	1.25e-05	12	136	3	28949961
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	USP34 CLGN RMND5A IPO7 RBBP4 TNPO2 VPS8 ABCF2 CORO1B IFIT1 PGM3 ARG2 MDN1 NUP155 CCT5 POP1 NUP188 IKBKB	1.37e-05	1440	136	18	30833792
Pubmed	Evidence of a sex-dependent restrictive epigenome in schizophrenia.	EHMT2 EHMT1	1.52e-05	2	136	2	25935252
Pubmed	mRNAs for activin receptors II and IIB are expressed in mouse oocytes and in the epiblast of pregastrula and gastrula stage mouse embryos.	ACVR2A ACVR2B	1.52e-05	2	136	2	7748787
Pubmed	Targeting H3K9 methyltransferase G9a and its related molecule GLP as a potential therapeutic strategy for cancer.	EHMT2 EHMT1	1.52e-05	2	136	2	33283949
Pubmed	Distinct roles for histone methyltransferases G9a and GLP in cancer germ-line antigen gene regulation in human cancer cells and murine embryonic stem cells.	EHMT2 EHMT1	1.52e-05	2	136	2	19531572
Pubmed	G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription.	EHMT2 EHMT1	1.52e-05	2	136	2	18818694
Pubmed	The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules.	EHMT2 EHMT1	1.52e-05	2	136	2	18264113
Pubmed	A post-translational modification switch controls coactivator function of histone methyltransferases G9a and GLP.	EHMT2 EHMT1	1.52e-05	2	136	2	28615290
Pubmed	Histone methyltransferases EHMT1 and EHMT2 (GLP/G9A) maintain PARP inhibitor resistance in high-grade serous ovarian carcinoma.	EHMT2 EHMT1	1.52e-05	2	136	2	31775874
Pubmed	Increased H3K9 methylation and impaired expression of Protocadherins are associated with the cognitive dysfunctions of the Kleefstra syndrome.	EHMT2 EHMT1	1.52e-05	2	136	2	29554304
Pubmed	Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are Associated with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing Sarcoma.	EHMT2 EHMT1	1.52e-05	2	136	2	37894922
Pubmed	Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability.	EHMT2 EHMT1	1.52e-05	2	136	2	25637356
Pubmed	Inhibition of euchromatic histone methyltransferase 1 and 2 sensitizes chronic myeloid leukemia cells to interferon treatment.	EHMT2 EHMT1	1.52e-05	2	136	2	25079219
Pubmed	G9a/GLP Complex Maintains Imprinted DNA Methylation in Embryonic Stem Cells.	EHMT2 EHMT1	1.52e-05	2	136	2	27052169
Pubmed	The histone H3 lysine 9 methyltransferase G9a/GLP complex activity is required for long-term consolidation of spatial memory in mice.	EHMT2 EHMT1	1.52e-05	2	136	2	33609736
Pubmed	Formation and activation by phosphorylation of activin receptor complexes.	ACVR2A ACVR2B	1.52e-05	2	136	2	8721982
Pubmed	Context-Dependent Requirement of Euchromatic Histone Methyltransferase Activity during Reprogramming to Pluripotency.	EHMT2 EHMT1	1.52e-05	2	136	2	32976761
Pubmed	Activin receptor type 2A (ACVR2A) functions directly in osteoblasts as a negative regulator of bone mass.	ACVR2A ACVR2B	1.52e-05	2	136	2	28659341
Pubmed	Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.	EHMT2 EHMT1	1.52e-05	2	136	2	15774718
Pubmed	Heterodimerization of H3K9 histone methyltransferases G9a and GLP activates methyl reading and writing capabilities.	EHMT2 EHMT1	1.52e-05	2	136	2	34619147
Pubmed	Functional Crosstalk Between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2.	EHMT2 EHMT1	1.52e-05	2	136	2	25365549
Pubmed	EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.	EHMT2 EHMT1	1.52e-05	2	136	2	26320100
Pubmed	EHMT1/EHMT2 in EMT, cancer stemness and drug resistance: emerging evidence and mechanisms.	EHMT2 EHMT1	1.52e-05	2	136	2	34954891
Pubmed	Expression of activin receptor II and IIB mRNA isoforms in mouse reproductive organs and oocytes.	ACVR2A ACVR2B	1.52e-05	2	136	2	8049070
Pubmed	GLP overexpression is associated with poor prognosis in Chronic Lymphocytic Leukemia and its inhibition induces leukemic cell death.	EHMT2 EHMT1	1.52e-05	2	136	2	29855824
Pubmed	Structure of the mouse activin receptor type II gene.	ACVR2A ACVR2B	1.52e-05	2	136	2	1318045
Pubmed	Characterization of type II activin receptors. Binding, processing, and phosphorylation.	ACVR2A ACVR2B	1.52e-05	2	136	2	8395525
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	PRUNE2 USP34 FLII IPO7 RBBP4 ABCF2 CORO1B CERT1 NUP155 CCT5 POP1 INTS9 NUP188 PLEC LRBA IKBKB HECTD1 USP47	1.57e-05	1455	136	18	22863883
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TOR1AIP2 USP34 LPCAT1 HDAC6 RBBP4 PHF12 ARG2 KSR1 EHMT2 ANAPC1 WRAP73 EHMT1 NUP188 WDFY3 WDR62	3.32e-05	1116	136	15	31753913
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	MYO7B RBBP4 SYNE1 MDN1 POP1 PLEC LRBA	3.99e-05	234	136	7	36243803
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	TOR1AIP2 LPCAT1 IPO7 CORO1B IFIT1 PLEC UTRN	4.10e-05	235	136	7	28378594
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	TOR1AIP2 LPCAT1 IPO7 PHF12 NBEA IFIT1 MDN1 EHMT1 WDFY3 HERC6 USP47	4.47e-05	638	136	11	31182584
Pubmed	FIH Is an Oxygen Sensor in Ovarian Cancer for G9a/GLP-Driven Epigenetic Regulation of Metastasis-Related Genes.	EHMT2 EHMT1	4.54e-05	3	136	2	29259012
Pubmed	The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia.	NBEA LRBA	4.54e-05	3	136	2	28814779
Pubmed	Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A.	EHMT2 EHMT1	4.54e-05	3	136	2	23112189
Pubmed	Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation.	ACVR2A ACVR2B	4.54e-05	3	136	2	14738881
Pubmed	Functional analysis of histone methyltransferase g9a in B and T lymphocytes.	EHMT2 EHMT1	4.54e-05	3	136	2	18566414
Pubmed	Regulation of muscle growth by multiple ligands signaling through activin type II receptors.	ACVR2A ACVR2B	4.54e-05	3	136	2	16330774
Pubmed	Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning.	ACVR2A ACVR2B	4.54e-05	3	136	2	12414726
Pubmed	Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity.	EHMT2 EHMT1	4.54e-05	3	136	2	27588951
Pubmed	LSH and G9a/GLP complex are required for developmentally programmed DNA methylation.	EHMT2 EHMT1	4.54e-05	3	136	2	21149390
Pubmed	Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.	ACVR2A ACVR2B	4.54e-05	3	136	2	26047946
Pubmed	The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy.	EHMT2 EHMT1	4.54e-05	3	136	2	27893464
Pubmed	Assignment of ACVR2 and ACVR2B the human activin receptor type II and IIB genes to chromosome bands 2q22.2-->q23.3 and 3p22 and the human follistatin gene (FST) to chromosome 5q11.2 by FISH.	ACVR2A ACVR2B	4.54e-05	3	136	2	10702675
Pubmed	Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex.	EHMT2 EHMT1	4.54e-05	3	136	2	20005824
Pubmed	The histone H3 lysine 9 methyltransferases G9a and GLP regulate polycomb repressive complex 2-mediated gene silencing.	EHMT2 EHMT1	4.54e-05	3	136	2	24389103
Pubmed	Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration.	EHMT2 EHMT1	4.54e-05	3	136	2	29860315
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	USP34 SYNE1 VPS8 KIAA0753 NUP155	4.98e-05	101	136	5	9872452
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	PRUNE2 IPO7 ASAP3 ANKRD62 RET NUP155 TMEM151A PLEC SPRTN	5.21e-05	430	136	9	35044719
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	USP34 CLGN RBBP4 TMEM94 RET ACVR2A LYST KSR1 ANAPC1 NUP188 PLEC IKBKB UTRN	6.20e-05	910	136	13	36736316
Pubmed	Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.	EHMT2 EHMT1 WDR62	6.35e-05	20	136	3	36551904
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	ZNF93 IPO7 PGM3 ZNF716 ZNF100 CCT5 ZSCAN21 ZNF257 ZNF506	7.50e-05	451	136	9	36168627
Pubmed	Knock down of heat shock protein 27 (HspB1) induces degradation of several putative client proteins.	HDAC6 STAT2	9.06e-05	4	136	2	22238643
Pubmed	Keap1 moderates the transcription of virus induced genes through G9a-GLP and NFκB p50 recruitment.	EHMT2 EHMT1	9.06e-05	4	136	2	35751391
Pubmed	Generation of activin receptor type IIB isoform-specific hypomorphic alleles.	ACVR2A ACVR2B	9.06e-05	4	136	2	16991118
Pubmed	TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence.	ACVR2A ACVR2B	9.06e-05	4	136	2	27696331
Pubmed	Genetic variants in epigenetic genes and breast cancer risk.	EHMT2 EHMT1	9.06e-05	4	136	2	16501248
Pubmed	Development of a Highly Sensitive ELISA for Measurement of FSH in Serum, Plasma, and Whole Blood in Mice.	ACVR2A ACVR2B	9.06e-05	4	136	2	33475143
Pubmed	Activin A accelerates the progression of fetal oocytes throughout meiosis and early oogenesis in the mouse.	ACVR2A ACVR2B	9.06e-05	4	136	2	26083127
Pubmed	The zinc finger proteins ZNF644 and WIZ regulate the G9a/GLP complex for gene repression.	EHMT2 EHMT1	9.06e-05	4	136	2	25789554
Pubmed	Murine FSH Production Depends on the Activin Type II Receptors ACVR2A and ACVR2B.	ACVR2A ACVR2B	9.06e-05	4	136	2	32270195
Pubmed	Regulation of myostatin activity and muscle growth.	ACVR2A ACVR2B	9.06e-05	4	136	2	11459935
Pubmed	Neurobeachin: A protein kinase A-anchoring, beige/Chediak-higashi protein homolog implicated in neuronal membrane traffic.	NBEA LYST	9.06e-05	4	136	2	11102458
Pubmed	G9a and Glp methylate lysine 373 in the tumor suppressor p53.	EHMT2 EHMT1	9.06e-05	4	136	2	20118233
Pubmed	MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.	EHMT2 EHMT1	9.06e-05	4	136	2	22086334
Pubmed	Myostatin, follistatin and activin type II receptors are highly expressed in adenomyosis.	ACVR2A ACVR2B	9.06e-05	4	136	2	26086422
Pubmed	A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis.	EHMT2 EHMT1	9.06e-05	4	136	2	22430489
Pubmed	Expression of inhibin/activin proteins and receptors in the human hypothalamus and basal forebrain.	ACVR2A ACVR2B	9.06e-05	4	136	2	22296042
Pubmed	Plectin 1f scaffolding at the sarcolemma of dystrophic (mdx) muscle fibers through multiple interactions with beta-dystroglycan.	PLEC UTRN	9.06e-05	4	136	2	17389230
Pubmed	Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.	ZNF302 MDN1 EHMT2 ANAPC1 EHMT1	9.62e-05	116	136	5	21549307
Pubmed	Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.	USP34 USP38 USP47	9.78e-05	23	136	3	14715245
Pubmed	Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human.	VPS8 MTMR6 WDFY3	1.11e-04	24	136	3	17452356
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	TOR1AIP2 HDAC6 USP38 LTBP1 PLEC SPRTN IKBKB HECTD1 USP47	1.22e-04	481	136	9	28190767
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	TOR1AIP2 USP34 CLGN IPO7 ABCF2 PGM3 MTMR6 NUP155 CCT5 NUP188 HECTD1 UTRN USP47	1.22e-04	974	136	13	28675297
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PRUNE2 SH3TC2 ANKRD62 NPHP4 GALNT16 DENND3 KIAA0753 POP1 HECTD1	1.47e-04	493	136	9	15368895
Pubmed	The functional interactome landscape of the human histone deacetylase family.	HDAC6 RBBP4 PHF12 MDN1 CCT5 EHMT2 USP47	1.49e-04	289	136	7	23752268
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	FLII IPO7 CNTNAP1 ANAPC1 PLEC HECTD1	1.50e-04	202	136	6	33005030
Pubmed	Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP.	EHMT2 EHMT1	1.51e-04	5	136	2	16702210
Pubmed	The distribution of activin and activin receptors in gestational tissues across human pregnancy and during labour.	ACVR2A ACVR2B	1.51e-04	5	136	2	11969340
Pubmed	Local versus systemic control of bone and skeletal muscle mass by components of the transforming growth factor-β signaling pathway.	ACVR2A ACVR2B	1.51e-04	5	136	2	34385332
Pubmed	Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway.	ACVR2A ACVR2B	1.51e-04	5	136	2	11882656
Pubmed	PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome.	EHMT2 EHMT1	1.51e-04	5	136	2	33311485
Pubmed	Automethylation of G9a and its implication in wider substrate specificity and HP1 binding.	EHMT2 EHMT1	1.51e-04	5	136	2	17962312
Pubmed	Degradation of the transcription factor Twist, an oncoprotein that promotes cancer metastasis.	KPNA7 IKBKB	1.51e-04	5	136	2	23375009
Pubmed	Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells.	ACVR2A ACVR2B	1.51e-04	5	136	2	9202237
Pubmed	SPOP mutation induces DNA methylation via stabilizing GLP/G9a.	EHMT2 EHMT1	1.51e-04	5	136	2	34588438
Pubmed	BCL8 is a novel, evolutionarily conserved human gene family encoding proteins with presumptive protein kinase A anchoring function.	NBEA LRBA	1.51e-04	5	136	2	12160729
Pubmed	IPO7 Promotes Odontoblastic Differentiation and Inhibits Osteoblastic Differentiation Through Regulation of RUNX2 Expression and Translocation.	HDAC6 IPO7	1.51e-04	5	136	2	35922041
Interaction	TRIM28 interactions	FLII ZNF93 ZNF567 ZNF486 RMND5A HDAC6 IPO7 RBBP4 ZNF273 CORO1B ZNF302 ZNF626 PGM3 ZNF430 CFD ZNF100 CCT5 EHMT2 ZNF257 ZNF253 EHMT1 ZNF737 NUP188 ZNF90 LRBA SPRTN HECTD1	1.04e-06	1474	133	27	int:TRIM28
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF93 ZNF486 ZNF626 ZNF430 ZNF100 ZNF257 ZNF737 ZNF90	3.49e-09	122	136	8	chr19p12
Cytoband	19p12	ZNF93 ZNF486 ZNF626 ZNF430 ZNF100 ZNF737 ZNF90	1.04e-08	90	136	7	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr4q22	GRID2 HERC3 HERC6	1.41e-03	74	136	3	chr4q22
Cytoband	Ensembl 112 genes in cytogenetic band chr17q11	WSB1 PHF12 KSR1 CORO6	1.73e-03	171	136	4	chr17q11
Cytoband	7q11.21	ZNF273 ZNF735 ZNF679	1.96e-03	83	136	3	7q11.21
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF93 ZNF567 ZNF486 ZNF273 ZNF302 ZNF626 ZNF430 ZNF716 ZNF100 ZSCAN21 ZNF257 ZNF253 ZNF735 ZNF737 ZNF506 ZNF479 ZFP69B ZNF90 ZNF679	7.20e-09	718	97	19	28
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEA LYST WDFY3 LRBA	9.61e-08	9	97	4	1230
GeneFamily	WD repeat domain containing	WSB1 RBBP4 NBEA CORO1B LYST DENND3 WRAP73 CORO6 WDFY3 LRBA WDR62	1.59e-07	262	97	11	362
GeneFamily	Armadillo repeat containing\|Importins	IPO7 TNPO2 KPNA7	1.15e-04	18	97	3	596
GeneFamily	Type 2 receptor serine/threonine kinases	ACVR2A ACVR2B	2.82e-04	5	97	2	346
GeneFamily	WD repeat domain containing\|Coronins	CORO1B CORO6	5.88e-04	7	97	2	495
GeneFamily	Histone deacetylases, class I\|EMSY complex\|NuRD complex\|SIN3 histone deacetylase complex	RBBP4 PHF12	1.82e-03	12	97	2	1243
GeneFamily	Ankyrin repeat domain containing	ASAP3 ANKRD62 EHMT2 ASB5 EHMT1 HECTD1	1.94e-03	242	97	6	403
GeneFamily	StAR related lipid transfer domain containing	CERT1 ACOT12	2.86e-03	15	97	2	759
GeneFamily	Ubiquitin specific peptidases	USP34 USP38 USP47	3.38e-03	56	97	3	366
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNT14 GALNT16	5.08e-03	20	97	2	433
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND3 DENND6B	7.89e-03	25	97	2	504
Coexpression	MIKKELSEN_MEF_ICP_WITH_H3K4ME3_AND_H3K27ME3	CNTNAP1 ZNF626 ZNF716 ZNF506 ZNF679	2.67e-06	43	134	5	MM837
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination__)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RMND5A ACVR2A DENND3 MTMR6 PTPRN SERAC1 SMOX	9.79e-07	171	136	7	d1e87478d8c0329e662849823f5c7604f20e1b1a
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CERKL PHF12 DGKA CORO1B ACVR2A LRBA UTRN	1.98e-06	190	136	7	91ba66d4b56c59523485b17738e93f14bb00afa4
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	USP34 USP38 ZNF253 WDFY3 ZFP69B HECTD1 UTRN	2.19e-06	193	136	7	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	LRRC66 SYNE1 DGKA ACVR2B LRBA DTHD1 UTRN	2.51e-06	197	136	7	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	CERKL LPCAT1 SYNE1 IFIT1 HERC6 DTHD1 UTRN	2.78e-06	200	136	7	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	USP34 DGKA ACVR2A ZNF506 LRBA UTRN	1.06e-05	162	136	6	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAPGEF5 SYNE1 LYST IFIT1 HERC6 UTRN	1.81e-05	178	136	6	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 GALNT14 PCDHA10 RET PRSS53 PTPRN	3.02e-05	195	136	6	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HDAC6 CARMIL3 NBEA RET PRSS53 PTPRN	3.02e-05	195	136	6	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HDAC6 CARMIL3 NBEA RET PRSS53 PTPRN	3.02e-05	195	136	6	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	CV-Moderate-1\|Moderate / Virus stimulation, Condition and Cluster	LYST IFIT1 STAT2 ARG2 HERC6 UTRN	3.11e-05	196	136	6	b50cfcd87c5b67806450cb8b3c6860ab97f6d3b1
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-skeletal_muscle_satellite_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TOR1AIP2 WSB1 IPO7 TCP11L2 ASB5 LTBP1	3.20e-05	197	136	6	5bc11aff92da2a0aca8473f997fe7a99f3cae75d
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-non-classical_monocyte-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	WSB1 LYST IFIT1 CFD UTRN IL3RA	3.20e-05	197	136	6	1463522df1b6358cbe3b5022a3e153878e9c9e43
ToppCell	COVID-19_Severe-NK_activated\|World / disease group, cell group and cell class	LPCAT1 CARMIL3 SYNE1 IFIT1 DTHD1 UTRN	3.20e-05	197	136	6	a60db36d1a192998e3ded63e0c7c08d41689f95f
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LPCAT1 SYNE1 IFIT1 HERC6 DTHD1 UTRN	3.29e-05	198	136	6	0e918e9db9b884f5328d438e90efe065e27266ee
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LPCAT1 SYNE1 IFIT1 HERC6 DTHD1 UTRN	3.29e-05	198	136	6	ce92d5fbc2eac27fb246b044fb1914ab92506275
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	LPCAT1 SYNE1 IFIT1 HERC6 DTHD1 UTRN	3.29e-05	198	136	6	fed823d6e684d113bcc9ff3cd1803bb001aa02fa
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-non-classical_monocyte\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	WSB1 LYST IFIT1 CFD UTRN IL3RA	3.29e-05	198	136	6	11b0d021114df73a539b04f76dd7c63f1fdbdf4f
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	LPCAT1 SYNE1 IFIT1 HERC6 DTHD1 UTRN	3.29e-05	198	136	6	1ef3a6bd681c223eed58300348adfef89df5563c
ToppCell	COVID-19_Severe-Lymphoid_T/NK-NK_activated\|COVID-19_Severe / Disease group, lineage and cell class	LPCAT1 SYNE1 IFIT1 HERC6 DTHD1 UTRN	3.39e-05	199	136	6	edf5f80b4c299e6bf462675f2cd3329d86c923d8
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	WSB1 SYNE1 LYST DENND3 PLXNC1 WDFY3	3.39e-05	199	136	6	b7af2b4fe6866cc8c78cf0f78390aab1b1b389ba
ToppCell	Sigmoid-(4)_Monocyte\|Sigmoid / shred on region, Cell_type, and subtype	MYO7B CD163 CFD LRP3 WDFY3 IL3RA	3.48e-05	200	136	6	7f3920a0434d5199c6c8f0b3064a305bb0d87b60
ToppCell	Sigmoid-Monocyte-Monocyte\|Sigmoid / Region, Cell class and subclass	MYO7B CD163 CFD LRP3 WDFY3 IL3RA	3.48e-05	200	136	6	010ca36970cb8894bdbca08779c0ecf56be22fc9
ToppCell	Sigmoid-Monocyte\|Sigmoid / Region, Cell class and subclass	MYO7B CD163 CFD LRP3 WDFY3 IL3RA	3.48e-05	200	136	6	c41bd6ec0f2262fce5cadb37a400d487e6662f49
ToppCell	Sigmoid-(4)_Monocyte-(40)_Monocyte\|Sigmoid / shred on region, Cell_type, and subtype	MYO7B CD163 CFD LRP3 WDFY3 IL3RA	3.48e-05	200	136	6	576c0a1098e6a934448705de3673ef798fcf1b26
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-NK_activated\|COVID-19_Severe / Disease, condition lineage and cell class	LPCAT1 SYNE1 IFIT1 HERC6 DTHD1 UTRN	3.48e-05	200	136	6	6a77f9643646bafc1157bf1fc1e4c614860ee642
ToppCell	COVID-19_Severe-NK_activated\|COVID-19_Severe / Disease condition and Cell class	LPCAT1 SYNE1 IFIT1 HERC6 DTHD1 UTRN	3.48e-05	200	136	6	f1f6c7f7f75f891c9ccf6bf58f4d65b9cf10bbd8
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic-neutrophil\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	WSB1 SYNE1 LYST DENND3 PLXNC1 WDFY3	3.48e-05	200	136	6	808571d74bb5c4d765ff13fc9393f88020d4e90d
ToppCell	LPS-IL1RA+antiTNF-Unknown-Endothelial\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRUNE2 CERKL TMEM94 FZD6 MDN1	5.33e-05	132	136	5	46c80eab16a70da9f363a9fbdf50bccab0b287d7
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-immature_T_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RMND5A ACVR2A PTPRN SERAC1 SMOX	5.33e-05	132	136	5	9936078c328b1e1d59f9dfdd69d36926a0cdaf0d
ToppCell	LPS-IL1RA+antiTNF-Unknown\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRUNE2 CERKL TMEM94 FZD6 MDN1	5.33e-05	132	136	5	a022c3c41654166cb106f27dc54fa88e8c40f898
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	LRRC66 MYO7B CARMIL3 MEIOC PTPRN	7.54e-05	142	136	5	819e983688d126d89a71abc03d72525cc759a347
Drug	Betaxolol hydrochloride [63659-19-8]; Down 200; 11.6uM; PC3; HT_HG-U133A	USP34 SYNE1 ASAP3 ABCF2 KIAA0753 ZNF253 HERC3 WDFY3 UTRN	2.45e-06	197	133	9	4608_DN
Drug	lipo-polysaccharide	NBEA LYST LRBA	1.60e-05	9	133	3	CID011970143
Drug	Carbamazepine [298-46-4]; Down 200; 17uM; HL60; HT_HG-U133A	WSB1 USP34 RMND5A ACVR2B KIAA0753 ZNF430 LRP3 HERC6	1.76e-05	192	133	8	1847_DN
Drug	Disulfiram [97-77-8]; Down 200; 13.4uM; HL60; HG-U133A	LPCAT1 RMND5A ACVR2A ACVR2B LYST DENND3 POP1 UTRN	1.90e-05	194	133	8	1369_DN
Drug	Lactobionic acid [96-82-2]; Up 200; 11.2uM; HL60; HT_HG-U133A	USP34 FLII CNPPD1 ZNF430 LRP3 HERC3 SMOX RUSF1	2.12e-05	197	133	8	1309_UP
Drug	fluphenazine dihydrochloride; Down 200; 10uM; MCF7; HG-U133A	ZNRF4 NPHP4 DENND3 CNPPD1 POP1 LRP3 IKBKB RUSF1	2.12e-05	197	133	8	490_DN
Drug	Propylthiouracil [51-52-5]; Down 200; 23.4uM; MCF7; HT_HG-U133A	TMEM120B DGKA LRCH1 CNPPD1 LRP3 NUP188 IKBKB HERC6	2.12e-05	197	133	8	2837_DN
Drug	Felbinac [5728-52-9]; Down 200; 18.8uM; MCF7; HT_HG-U133A	TMEM120B CLGN RMND5A ABCF2 STAT2 TLR5 HERC3 WDR62	2.20e-05	198	133	8	3398_DN
Disease	Kleefstra syndrome 1 (implicated_via_orthology)	EHMT2 EHMT1	2.02e-05	2	133	2	DOID:0060352 (implicated_via_orthology)
Disease	Chediak-Higashi syndrome (implicated_via_orthology)	LYST WDFY3	1.20e-04	4	133	2	DOID:2935 (implicated_via_orthology)
Disease	viral infectious disease (implicated_via_orthology)	EHMT2 EHMT1	2.00e-04	5	133	2	DOID:934 (implicated_via_orthology)
Disease	1,5 anhydroglucitol measurement	PCDHA11 PCDHA10 PKD1L2	3.00e-04	29	133	3	EFO_0008009
Disease	idiopathic pulmonary fibrosis (is_implicated_in)	MUC5B EHMT2	7.11e-04	9	133	2	DOID:0050156 (is_implicated_in)
Disease	Marfan syndrome (implicated_via_orthology)	ACVR2A ACVR2B	8.86e-04	10	133	2	DOID:14323 (implicated_via_orthology)
Disease	outer ear morphology trait	MYO3B LRBA	1.29e-03	12	133	2	EFO_0007664
Disease	juvenile polyposis syndrome (implicated_via_orthology)	ACVR2A ACVR2B	1.52e-03	13	133	2	DOID:0050787 (implicated_via_orthology)
Disease	level of triacylglycerol (56:6) in blood serum	ZNF93 ZNF90	2.32e-03	16	133	2	OBA_2020007
Disease	Sclerocystic Ovaries	CARMIL3 TNPO2 ZNF430 TMEM151A	4.17e-03	144	133	4	C1136382
Disease	Polycystic Ovary Syndrome	CARMIL3 TNPO2 ZNF430 TMEM151A	4.17e-03	144	133	4	C0032460
Disease	Intellectual Disability	TMEM94 SYNE1 NBEA CERT1 PGM3 SERAC1 WDR62	4.24e-03	447	133	7	C3714756

Protein segments in the cluster

Peptide	Gene	Start	Entry
ASCFDSILQLEQSHW	EXOC3L4	391	Q17RC7
TNHLDLDACVWLEEE	ABCF2	256	Q9UG63
SWEEHATCLANAEEQ	PGM3	86	O95394
AEDEHECEAWVSVLQ	ASAP3	376	Q8TDY4
WEEVSALANASQHCE	CNTNAP1	656	P78357
DLCVVWVDAHADINT	ARG2	136	P78540
ANVVSWNELCHIAET	ACVR2A	281	P27037
FQSTVNEWCHLQEDT	ANKRD62	681	A6NC57
LDIDWCPHNDEVIAS	CORO1B	86	Q9BR76
IDWVSEDDQLYHITC	ACOT12	426	Q8WYK0
VTLTDNEENICLHWA	EHMT2	811	Q96KQ7
FLDLTRCQINWIHED	CD180	81	Q99467
ALHLEAICEANIETW	DENND6B	511	Q8NEG7
EVFEANLKTECDLWH	DENND3	791	A2RUS2
SQFWEQELESLHFVI	CCDC69	171	A6NI79
VLTFLDSHCEVNTEW	GALNT16	206	Q8N428
ILWHQGCETEVNITF	MUC5B	5666	Q9HC84
SLEFSQIFAEWLCHN	INTS9	336	Q9NV88
ELCIDHLWTETITNI	ANAPC1	406	Q9H1A4
NDPETWIVCNFSVDH	CERT1	521	Q9Y5P4
VAEQWVLSAAHCLED	CFD	56	P00746
GHCTVWVEILDTNDN	PCDHA11	331	Q9Y5I1
LGHWLYQTELVENEC	TOR1AIP2	21	Q9H496
EVNLVSEHIWCEDFL	PTPRN	836	Q16849
EILWLTLCQFHNQVE	LPCAT1	256	Q8NF37
QHQDSEVLSDACWAL	KPNA7	251	A9QM74
ETAHLLQIWTVVDFC	KLHL36	121	Q8N4N3
WGTICDDDFTLQAAH	LOXL3	66	P58215
HVCQEIISEWDEQER	MDN1	3526	Q9NU22
DVPWEELHNRFQSLC	FANCF	301	Q9NPI8
LSLCIDQWVHVETLN	FLII	261	Q13045
WLQTEEEEHSCLEQA	IKBKB	741	O14920
VFTQFLECVWHLTEQ	MTMR6	396	Q9Y217
DSNLLWFSDTCFVEH	HERC3	771	Q15034
CREEVQWDVDTIYHA	CARMIL3	171	Q8ND23
VVETNLVAFDCHWII	GRID2	246	O43424
LVAFDCHWIIINEEI	GRID2	251	O43424
CHWIIINEEINDVDV	GRID2	256	O43424
DCVHSENLENWLDIS	PLXNC1	486	O60486
HFITQWLNDVDCFLG	IPO7	816	O95373
EVSEILSACWAFDLQ	KSR1	851	Q8IVT5
IEETDVYQDLCWEHL	LTBP1	1516	Q14766
NLDEEWATEHACQVS	ODR4	66	Q5SWX8
DALCIRFSIHWDQND	HERC6	821	Q8IVU3
VWCHLEIHDDCLQAV	DGKA	301	P23743
LESEFVSCQLHQWID	LRBA	2411	P50851
FDVEESHQCSLDWLL	LRP3	91	O75074
CEELLRIEEDVHWQT	LRCH1	421	Q9Y2L9
IQHLWIAANCDIADE	CHRFAM7A	16	Q494W8
ESAVTELQCIWHNLS	IL13RA1	126	P78552
EWHCSLRDLEFSNVD	LRRC66	836	Q68CR7
NLVDVDCHQLVASWL	NPHP4	1306	O75161
EDNDILWCVNHDTFP	NUP155	426	O75694
ASDDHTICLWDISAV	RBBP4	196	Q09028
TTFLSHCVFWDEVQE	PKD1L2	1276	Q7Z442
CHIFTVSAWDADAQE	PCDHA10	471	Q9Y5I2
TFLDSHCEVNRDWLQ	GALNT14	196	Q96FL9
VECTHSFIWNQDICK	POP1	546	Q99575
SCEAIEQKAVWFHAV	FZD6	316	O60353
HWEEEECQQDVSLLR	ENOPH1	46	Q9UHY7
IFEVLSWLESCVAEQ	CNPPD1	181	Q9BV87
LESSWELHTNRQCIE	HECTD1	866	Q9ULT8
GAENLTCWIHDVDFL	IL3RA	106	P26951
ERTWTDLEENLCNHD	CENPJ	796	Q9HC77
HECLDILISWGIDVD	ASB5	181	Q8WWX0
INLSEDHCDIWFRQF	CERKL	141	Q49MI3
DIDWCPHNDNVIASA	CORO6	86	Q6QEF8
PDDLTEQIHEFLCFW	DTHD1	716	Q6ZMT9
SLWFNVECIHEAEST	LYST	1476	Q99698
QLRCHFTWELSIDDD	IFIT1	16	P09914
QDCFDVHDASWEEQI	KLHDC1	151	Q8N7A1
DEQLNEFHCLWDDSF	HDAC6	91	Q9UBN7
DSWDLSDAHVVCRQL	CD163	746	Q86VB7
IRDNEENICLHWAAF	EHMT1	901	Q9H9B1
FCKNLTNDWEDHLAV	HSP90AA2P	311	Q14568
LVEGHQESYLLCWDQ	RUSF1	346	Q96GQ5
ASELHIRLEECCEQW	MEIOC	751	A2RUB1
EEWRQFHCDLNDLTQ	UTRN	1976	P46939
FHCDLNDLTQWITEA	UTRN	1981	P46939
FSTVDIEDHECAVWL	SERAC1	121	Q96JX3
TLLQNCWSELLVFDH	NR5A1	296	Q13285
VHLLDANQWADICDI	RMND5A	251	Q9H871
TCSWVEHQDDDKVLI	STAT2	611	P52630
NCHVAEDESRAWDSL	PRUNE2	1706	Q8WUY3
IVHQAFWDVLDSELN	TCP11L2	106	Q8N4U5
ELSSHEECREWQVFV	TMEM120B	291	A0PK00
EHQQFDELLLSFSVW	SYNE1	1766	Q8NF91
ESEFVSCQLHQWIDL	NBEA	2486	Q8NFP9
EHLATQAEQQEWLCS	PHF12	421	Q96QT6
FDWSLFNSIHEQELI	RAPGEF5	356	Q92565
IEHTICNSQTLEDIW	SHLD3	171	Q6ZNX1
ICQWGFDDEANHLLL	CCT5	301	P48643
DHKYWLNCILVEDTE	SH3TC2	141	Q8TF17
DCLTEALALAWSFHE	VPS8	511	Q8N3P4
TCLDQIQHIEWSADS	WRAP73	46	Q9P2S5
IQHIEWSADSLFILC	WRAP73	51	Q9P2S5
VDFTELEWHICSNRQ	TMEM151A	341	Q8N4L1
FLEDCASELWAVTHA	KIAA0753	741	Q2KHM9
DISVHCDVHIFNWLI	SANBR	191	Q6NSI8
AQLCVTIEECWDHDA	ACVR2B	451	Q13705
NFIICSEKEVADHWA	CLGN	426	O14967
LVADTWVLTAAHCFE	PRSS53	66	Q2L4Q9
HTCLEENWKAEDFLV	ZNF567	71	Q8N184
IEFSLEEWHCLDTAQ	ZNF93	11	P35789
AIEFSLEEWQCLDSA	ZNF100	41	Q8IYN0
DVAIEFSLEEWQCLD	ZNF273	41	Q14593
ASIDDENCWHLDEEQ	ZSWIM5	326	Q9P217
VEFCNDHDVWKLNVA	TTC30B	451	Q8N4P2
IAIEFSLAEWQCLDH	ZNF735	21	P0CB33
LQAWVQEHCPESAEE	ZSCAN21	101	Q9Y5A6
TAFQDLLCDFEVWLH	WDFY3	1496	Q8IZQ1
SCIQFDDSNWQLHLT	TMEM94	566	Q12767
HDENVALEACEFWLT	TNPO2	266	O14787
VVIEFSLEEWQCLDH	ZNF679	21	Q8IYX0
TFTWHNDLCAICLDE	ZNRF4	301	Q8WWF5
CNSLQFVWEDEAESH	SMOX	381	Q9NWM0
CDISVLDIHQDLDWN	USP47	1281	Q96K76
IAIEFSLAEWQCLDH	ZNF716	21	A6NP11
WSCLHAVLELIDSQQ	NUP188	956	Q5SRE5
DHQTYLELSEQECEW	PLEC	4301	Q15149
VESAEHWLDEAQCEA	USP38	26	Q8NB14
NEVLESQINEHLDWC	SPRTN	461	Q9H040
SQINEHLDWCLEGDS	SPRTN	466	Q9H040
HENNWICIQEDTGLL	RET	81	P07949
IAIEFSLEEWQCLDC	ZNF479	21	Q96JC4
IEFSLEEWHCLDTAQ	ZNF626	11	Q68DY1
VSTFLWIHSQLEAEC	WDR62	1451	O43379
AIEFSLEEWQCLDTA	ZNF430	41	Q9H8G1
IEFSLEEWHCLDTAQ	ZNF253	11	O75346
IEFSLEEWHCLDTAQ	ZNF90	11	Q03938
SALQNDISWEELHCG	ZFP69B	156	Q9UJL9
VEFCNDHDVWKLNVA	TTC30A	451	Q86WT1
LSLEQVDILWHCLVE	USP34	1006	Q70CQ2
EHIIDCGDIVWSLAF	WSB1	101	Q9Y6I7
EGWLVETVHSNCDLD	UGGT2	1056	Q9NYU1
TELCWDVFEGLSHLQ	TLR5	491	O60602
EFSLEEWHCLDTAQQ	ZNF486	21	Q96H40
IEFSLEEWHCLDAAQ	ZNF506	11	Q5JVG8
IAIEFSLEEWQCLDC	ZNF722	21	A0A1W2PQL4
VEFSLEEWHCLDTAQ	ZNF257	11	Q9Y2Q1
IEFSLEEWHCLDTAQ	ZNF737	11	O75373
IDFSHEEWACLDSAQ	ZNF302	11	Q9NR11
KWCEEFNHFISQCLI	MYO3B	261	Q8WXR4
HEDDTDCLAALVIWN	MYO7B	1001	Q6PIF6