Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninterleukin-8 receptor activity

CXCR1 CXCR2

8.01e-062572GO:0004918
GeneOntologyMolecularFunctionvoltage-gated monoatomic anion channel activity

GPR89B ANO6 GPR89A

1.46e-0517573GO:0008308
GeneOntologyMolecularFunctioninterleukin-8 binding

CXCR1 CXCR2

2.40e-053572GO:0019959
GeneOntologyMolecularFunctionC-X-C chemokine binding

CXCR1 CXCR2

1.67e-047572GO:0019958
GeneOntologyMolecularFunctionmonoatomic anion channel activity

LRRC8E GPR89B ANO6 GPR89A

2.14e-04103574GO:0005253
GeneOntologyMolecularFunctionC-X-C chemokine receptor activity

CXCR1 CXCR2

2.22e-048572GO:0016494
GeneOntologyMolecularFunctionG protein-coupled receptor activity

DRD1 GPR18 GPR19 ADGRG2 GPR141 OR5K3 TAS2R40 CXCR1 CXCR2

8.34e-04884579GO:0004930
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

LRRC8E GPR89B ANO6 GPR89A

9.09e-04151574GO:0008509
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

GPR89B ANO6 GPR89A RYR1

1.81e-03182574GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

GPR89B ANO6 GPR89A RYR1

1.88e-03184574GO:0022832
GeneOntologyMolecularFunctionC-C chemokine receptor activity

CXCR1 CXCR2

1.95e-0323572GO:0016493
GeneOntologyMolecularFunctionC-C chemokine binding

CXCR1 CXCR2

2.12e-0324572GO:0019957
GeneOntologyMolecularFunctionG protein-coupled chemoattractant receptor activity

CXCR1 CXCR2

2.49e-0326572GO:0001637
GeneOntologyMolecularFunctiondopamine receptor binding

DRD1 VPS35

2.49e-0326572GO:0050780
GeneOntologyMolecularFunctionchemokine receptor activity

CXCR1 CXCR2

2.49e-0326572GO:0004950
GeneOntologyMolecularFunctioncytokine receptor activity

IL1RL2 CXCR1 CXCR2

2.69e-0397573GO:0004896
GeneOntologyMolecularFunctiondynein light intermediate chain binding

CCDC88A DNAH8

2.89e-0328572GO:0051959
GeneOntologyBiologicalProcessclathrin-coated vesicle cargo loading

AP3B2 AP3B1 AP3D1

7.33e-077583GO:0035652
GeneOntologyBiologicalProcessclathrin-coated vesicle cargo loading, AP-3-mediated

AP3B2 AP3B1 AP3D1

7.33e-077583GO:0035654
GeneOntologyBiologicalProcessinterleukin-8-mediated signaling pathway

CXCR1 CXCR2

7.77e-062582GO:0038112
GeneOntologyBiologicalProcesscellular response to interleukin-8

CXCR1 CXCR2

2.33e-053582GO:0098759
GeneOntologyBiologicalProcessresponse to interleukin-8

CXCR1 CXCR2

2.33e-053582GO:0098758
GeneOntologyBiologicalProcessanterograde synaptic vesicle transport

AP3B2 AP3B1 AP3D1

3.13e-0522583GO:0048490
GeneOntologyBiologicalProcesssynaptic vesicle cytoskeletal transport

AP3B2 AP3B1 AP3D1

3.13e-0522583GO:0099514
GeneOntologyBiologicalProcesssynaptic vesicle transport along microtubule

AP3B2 AP3B1 AP3D1

3.13e-0522583GO:0099517
GeneOntologyBiologicalProcessdendritic cell chemotaxis

ANO6 CXCR1 CXCR2

7.32e-0529583GO:0002407
GeneOntologyBiologicalProcesssynaptic vesicle coating

AP3B2 AP3D1

7.73e-055582GO:0016183
GeneOntologyBiologicalProcesspositive regulation of NK T cell differentiation

AP3B1 AP3D1

7.73e-055582GO:0051138
GeneOntologyBiologicalProcessT cell differentiation

GPR89B SLC46A2 GPR18 GPR89A AP3B1 IL1RL2 AP3D1

9.44e-05382587GO:0030217
GeneOntologyBiologicalProcessmulticellular organismal reproductive process

GMCL1 DRD1 TDRD9 ADGRG2 USP42 PIK3CA EIF2S2 ASPM CFAP206 GARIN1B AP3B1 PTGIS

1.00e-0411945812GO:0048609
GeneOntologyBiologicalProcessdendritic cell migration

ANO6 CXCR1 CXCR2

1.41e-0436583GO:0036336
GeneOntologyBiologicalProcessvesicle cargo loading

AP3B2 AP3B1 AP3D1

1.41e-0436583GO:0035459
GeneOntologyBiologicalProcessantigen processing and presentation, exogenous lipid antigen via MHC class Ib

AP3B1 AP3D1

1.62e-047582GO:0048007
GeneOntologyBiologicalProcessantigen processing and presentation of lipid antigen via MHC class Ib

AP3B1 AP3D1

1.62e-047582GO:0048003
GeneOntologyBiologicalProcessregulation of NK T cell differentiation

AP3B1 AP3D1

1.62e-047582GO:0051136
GeneOntologyBiologicalProcesscyclic-GMP-AMP transmembrane import across plasma membrane

LRRC8E SLC46A2

2.15e-048582GO:0140361
GeneOntologyBiologicalProcessguanine nucleotide transmembrane transport

LRRC8E SLC46A2

3.45e-0410582GO:1903790
GeneOntologyBiologicalProcessgamete generation

GMCL1 TDRD9 ADGRG2 USP42 PIK3CA EIF2S2 ASPM CFAP206 GARIN1B AP3B1

3.72e-049825810GO:0007276
GeneOntologyBiologicalProcessvesicle transport along microtubule

AP3B2 AP3B1 AP3D1

3.99e-0451583GO:0047496
GeneOntologyBiologicalProcesscyclic nucleotide transport

LRRC8E SLC46A2

4.21e-0411582GO:0070729
GeneOntologyBiologicalProcessguanine nucleotide transport

LRRC8E SLC46A2

4.21e-0411582GO:0001408
GeneOntologyBiologicalProcesssynaptic vesicle budding from presynaptic endocytic zone membrane

AP3B2 AP3D1

4.21e-0411582GO:0016185
GeneOntologyBiologicalProcesscytoskeleton-dependent intracellular transport

CCDC88A MYO10 AP3B2 AP3B1 AP3D1

4.23e-04225585GO:0030705
GeneOntologyBiologicalProcesssynaptic vesicle transport

AP3B2 AP3B1 AP3D1

4.73e-0454583GO:0048489
GeneOntologyBiologicalProcessanterograde axonal transport

AP3B2 AP3B1 AP3D1

4.99e-0455583GO:0008089
GeneOntologyBiologicalProcessdevelopmental process involved in reproduction

GMCL1 TDRD9 ADGRG2 USP42 PIK3CA EIF2S2 ASPM CFAP206 GARIN1B AP3B1 PTGIS

5.72e-0412355811GO:0003006
GeneOntologyBiologicalProcessNK T cell differentiation

AP3B1 AP3D1

6.92e-0414582GO:0001865
GeneOntologyBiologicalProcessT cell activation

GPR89B SLC46A2 GPR18 PIK3CA GPR89A AP3B1 IL1RL2 AP3D1

7.31e-04701588GO:0042110
GeneOntologyBiologicalProcesslymphocyte differentiation

GPR89B SLC46A2 GPR18 GPR89A AP3B1 IL1RL2 AP3D1

7.43e-04537587GO:0030098
GeneOntologyBiologicalProcessimport into cell

LRRC8E SLC46A2 DRD1 PIK3CA ANO6 AP3B2 SNX9 AP3D1 CXCR1 CXCR2

7.49e-0410745810GO:0098657
GeneOntologyBiologicalProcesssynaptic vesicle budding

AP3B2 AP3D1

7.97e-0415582GO:0070142
GeneOntologyBiologicalProcessvesicle cytoskeletal trafficking

AP3B2 AP3B1 AP3D1

8.90e-0467583GO:0099518
GeneOntologyBiologicalProcessmonoatomic anion transmembrane transport

LRRC8E GPR89B ANO6 GPR89A

9.05e-04153584GO:0098656
GeneOntologyBiologicalProcesssexual reproduction

GMCL1 TDRD9 ADGRG2 USP42 PIK3CA EIF2S2 ASPM CFAP206 GARIN1B AP3B1 IQUB

9.45e-0413125811GO:0019953
GeneOntologyBiologicalProcessintracellular protein transport

DRD1 PTPN14 AP3B2 VPS35 SEC63 AP3B1 SNX9 AP3D1

1.04e-03740588GO:0006886
GeneOntologyBiologicalProcesssynaptic vesicle localization

AP3B2 AP3B1 AP3D1

1.05e-0371583GO:0097479
GeneOntologyBiologicalProcessspermatogenesis

GMCL1 TDRD9 ADGRG2 USP42 ASPM CFAP206 GARIN1B AP3B1

1.07e-03744588GO:0007283
GeneOntologyCellularComponentcytoplasmic vesicle membrane

GPR89B SLC46A2 ATP13A4 GPR18 ANO6 INPP4A AP3B2 VPS35 GPR89A CADPS2 AP3B1 SNX9 AP3D1 TMBIM1 CXCR1 CXCR2

3.26e-0713075816GO:0030659
GeneOntologyCellularComponentvesicle membrane

GPR89B SLC46A2 ATP13A4 GPR18 ANO6 INPP4A AP3B2 VPS35 GPR89A CADPS2 AP3B1 SNX9 AP3D1 TMBIM1 CXCR1 CXCR2

3.92e-0713255816GO:0012506
GeneOntologyCellularComponentAP-3 adaptor complex

AP3B2 AP3B1 AP3D1

5.68e-0613583GO:0030123
GeneOntologyCellularComponentGolgi apparatus subcompartment

GPR89B AP3B2 GPR89A CHST6 AP3B1 SNX9 AP3D1

2.17e-04443587GO:0098791
GeneOntologyCellularComponentplasma membrane bounded cell projection cytoplasm

AP3B2 CFAP206 AP3B1 DNAH8 AP3D1 IQUB

2.42e-04317586GO:0032838
GeneOntologyCellularComponentAP-type membrane coat adaptor complex

AP3B2 AP3B1 AP3D1

3.21e-0448583GO:0030119
GeneOntologyCellularComponentcytoplasmic region

AP3B2 CFAP206 AP3B1 DNAH8 AP3D1 IQUB

4.76e-04360586GO:0099568
GeneOntologyCellularComponentmembrane protein complex

LRRC8E GPR89B DRD1 PIK3CA ANO6 AP3B2 VPS35 GPR89A SEC63 AP3B1 AP3D1 RYR1

7.13e-0414985812GO:0098796
GeneOntologyCellularComponentradial spoke

CFAP206 IQUB

7.76e-0415582GO:0001534
GeneOntologyCellularComponentaxon cytoplasm

AP3B2 AP3B1 AP3D1

8.94e-0468583GO:1904115
GeneOntologyCellularComponenttrans-Golgi network

AP3B2 CHST6 AP3B1 SNX9 AP3D1

1.58e-03306585GO:0005802
GeneOntologyCellularComponentearly endosome

ATP13A4 INPP4A AP3B2 VPS35 AP3B1 AP3D1

2.12e-03481586GO:0005769
DomainARM-type_fold

PIK3CA AP3B2 VPS35 ASPM AP3B1 TRRAP NCAPG2 AP3D1

7.21e-06339568IPR016024
DomainAP3_beta

AP3B2 AP3B1

8.83e-062562IPR026740
DomainAP3B_C

AP3B2 AP3B1

8.83e-062562IPR029390
DomainAP3B1_C

AP3B2 AP3B1

8.83e-062562PF14796
DomainTyr_Pase_non-rcpt_typ-14/21

PTPN14 PTPN21

8.83e-062562IPR014392
DomainAP3B1_C

AP3B2 AP3B1

8.83e-062562SM01355
DomainChemokine_CXCR_1/2

CXCR1 CXCR2

8.83e-062562IPR000174
DomainClathrin/coatomer_adapt-like_N

AP3B2 AP3B1 AP3D1

1.13e-0515563IPR002553
DomainAdaptin_N

AP3B2 AP3B1 AP3D1

1.13e-0515563PF01602
Domain-

AP3B2 ASPM AP3B1 TRRAP NCAPG2 AP3D1

5.21e-052225661.25.10.10
DomainAP_beta

AP3B2 AP3B1

8.78e-055562IPR026739
DomainARM-like

AP3B2 ASPM AP3B1 TRRAP NCAPG2 AP3D1

1.53e-04270566IPR011989
DomainCXCR4/ACKR2

CXCR1 CXCR2

1.84e-047562IPR001277
DomainFERM_M

PTPN14 MYO10 PTPN21

3.54e-0446563PF00373
Domain-

PTPN14 MYO10 PTPN21

4.27e-04495631.20.80.10
DomainFERM_central

PTPN14 MYO10 PTPN21

4.27e-0449563IPR019748
DomainFERM_domain

PTPN14 MYO10 PTPN21

4.27e-0449563IPR000299
DomainFERM_1

PTPN14 MYO10 PTPN21

4.53e-0450563PS00660
DomainFERM_2

PTPN14 MYO10 PTPN21

4.53e-0450563PS00661
DomainFERM_3

PTPN14 MYO10 PTPN21

4.53e-0450563PS50057
DomainBand_41_domain

PTPN14 MYO10 PTPN21

4.53e-0450563IPR019749
DomainB41

PTPN14 MYO10 PTPN21

4.53e-0450563SM00295
DomainFERM/acyl-CoA-bd_prot_3-hlx

PTPN14 MYO10 PTPN21

4.53e-0450563IPR014352
Domain-

PIK3CA TRRAP

1.03e-03165621.10.1070.11
DomainPI3Kc

PIK3CA TRRAP

1.03e-0316562SM00146
DomainPI3/4_kinase_cat_dom

PIK3CA TRRAP

1.31e-0318562IPR000403
DomainPI3_PI4_kinase

PIK3CA TRRAP

1.31e-0318562PF00454
DomainPI3_4_KINASE_3

PIK3CA TRRAP

1.31e-0318562PS50290
DomainPI3_4_KINASE_1

PIK3CA TRRAP

1.31e-0318562PS00915
DomainPI3_4_KINASE_2

PIK3CA TRRAP

1.31e-0318562PS00916
DomainC2_dom

PIK3CA INPP4A SEC63 CADPS2

1.48e-03164564IPR000008
DomainUbiquitin-rel_dom

PTPN14 PIK3CA PTPN21 IQUB

2.25e-03184564IPR029071
DomainFERM_CS

PTPN14 PTPN21

2.34e-0324562IPR019747
DomainIQ

MYO10 ASPM IQUB

2.74e-0393563PS50096
DomainFERM_C

PTPN14 PTPN21

2.74e-0326562PF09380
DomainFERM_C

PTPN14 PTPN21

2.95e-0327562SM01196
DomainFERM_PH-like_C

PTPN14 PTPN21

2.95e-0327562IPR018980
DomainP-loop_NTPase

TDRD9 ERCC6L MYO10 ATAD2B ASPM CHST6 PFKFB2 DNAH8

3.59e-03848568IPR027417
DomainGPCR_Rhodpsn_7TM

DRD1 GPR18 GPR19 GPR141 OR5K3 CXCR1 CXCR2

3.73e-03670567IPR017452
Domain7tm_1

DRD1 GPR18 GPR19 GPR141 OR5K3 CXCR1 CXCR2

3.95e-03677567PF00001
DomainG_PROTEIN_RECEP_F1_1

DRD1 GPR18 GPR19 GPR141 OR5K3 CXCR1 CXCR2

4.21e-03685567PS00237
DomainFERM_N

PTPN14 PTPN21

4.39e-0333562PF09379
DomainFERM_N

PTPN14 PTPN21

4.39e-0333562IPR018979
DomainG_PROTEIN_RECEP_F1_2

DRD1 GPR18 GPR19 GPR141 OR5K3 CXCR1 CXCR2

4.42e-03691567PS50262
DomainGPCR_Rhodpsn

DRD1 GPR18 GPR19 GPR141 OR5K3 CXCR1 CXCR2

4.45e-03692567IPR000276
DomainPTPc

PTPN14 PTPN21

5.21e-0336562SM00194
DomainTYR_PHOSPHATASE_PTP

PTPN14 PTPN21

6.09e-0339562PS50055
DomainPTPase_domain

PTPN14 PTPN21

6.72e-0341562IPR000242
DomainY_phosphatase

PTPN14 PTPN21

6.72e-0341562PF00102
Pubmed

Regulation of large dense-core vesicle volume and neurotransmitter content mediated by adaptor protein 3.

AP3B2 AP3B1 AP3D1

1.76e-08458316788073
Pubmed

Adaptor protein-3 produces synaptic vesicles that release phasic dopamine.

AP3B2 AP3B1 AP3D1

4.39e-08558337812725
Pubmed

Association analysis between schizophrenia and the AP-3 complex genes.

AP3B2 AP3B1 AP3D1

4.39e-08558319481122
Pubmed

Genetic analysis of the neuronal and ubiquitous AP-3 adaptor complexes reveals divergent functions in brain.

AP3B2 AP3B1 AP3D1

8.77e-08658315537701
Pubmed

Characterization of the adaptor-related protein complex, AP-3.

AP3B2 AP3B1 AP3D1

1.53e-0775839151686
Pubmed

Association of the AP-3 adaptor complex with clathrin.

AP3B2 AP3B1 AP3D1

2.45e-0785839545220
Pubmed

AP-3 and Rabip4' coordinately regulate spatial distribution of lysosomes.

AP3B2 AP3B1 AP3D1

3.67e-07958323144738
Pubmed

HIV-1 Vpu inhibits accumulation of the envelope glycoprotein within clathrin-coated, Gag-containing endosomes.

AP3B2 AP3B1 AP3D1

5.24e-071058318076669
Pubmed

Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles.

AP3B2 AP3B1 AP3D1

9.58e-071258319144828
Pubmed

Cell type-specific Rab32 and Rab38 cooperate with the ubiquitous lysosome biogenesis machinery to synthesize specialized lysosome-related organelles.

AP3B2 AP3B1 AP3D1

2.43e-061658323247405
Pubmed

Effects of CXCR1 and CXCR2 inhibition on expansion and differentiation of umbilical cord blood CD133(+) cells into megakaryocyte progenitor cells.

CXCR1 CXCR2

2.73e-06258221555225
Pubmed

Small interfering RNA-mediated CXCR1 or CXCR2 knock-down inhibits melanoma tumor growth and invasion.

CXCR1 CXCR2

2.73e-06258219585580
Pubmed

CXC chemokine receptor-1 is expressed by hepatocytes and regulates liver recovery after hepatic ischemia/reperfusion injury.

CXCR1 CXCR2

2.73e-06258221254176
Pubmed

Attenuation of murine allergic airway inflammation with a CXCR1/CXCR2 chemokine receptor inhibitor.

CXCR1 CXCR2

2.73e-06258230218547
Pubmed

Collagen-Derived N-Acetylated Proline-Glycine-Proline in Intervertebral Discs Modulates CXCR1/2 Expression and Activation in Cartilage Endplate Stem Cells to Induce Migration and Differentiation Toward a Pro-Inflammatory Phenotype.

CXCR1 CXCR2

2.73e-06258226302999
Pubmed

Elevated expression of the interleukin-8 receptors CXCR1 and CXCR2 in peripheral blood cells in obstructive coronary artery disease.

CXCR1 CXCR2

2.73e-06258221915051
Pubmed

The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature.

CXCR1 CXCR2

2.73e-06258218668539
Pubmed

Expression of CXCR-1 and CXCR-2 chemokine receptors on synovial neutrophils in inflammatory arthritides: does persistent or increasing expression of CXCR-2 contribute to the chronic inflammation or erosive changes?

CXCR1 CXCR2

2.73e-06258216987681
Pubmed

Bronchoepithelial expression of CXCR1 and CXCR2 does not facilitate transepithelial migration of neutrophils.

CXCR1 CXCR2

2.73e-06258222076427
Pubmed

Intracellular trafficking of human CXCR1 and CXCR2: regulation by receptor domains and actin-related kinases.

CXCR1 CXCR2

2.73e-06258212442335
Pubmed

Roles of mechanical force and CXCR1/CXCR2 in shear-stress-induced endothelial cell migration.

CXCR1 CXCR2

2.73e-06258221989491
Pubmed

Different roles of CXCR1 and CXCR2 in HTLV-1 carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients.

CXCR1 CXCR2

2.73e-06258230341468
Pubmed

Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B.

CXCR1 CXCR2

2.73e-0625827929358
Pubmed

CXCR1 and CXCR2 are novel mechano-sensors mediating laminar shear stress-induced endothelial cell migration.

CXCR1 CXCR2

2.73e-06258221036625
Pubmed

[Effects of Xiaotan Sanjie Decoction on expressions of interleukin-8 and its receptors in gastric tumor xenografts and gastric tissue adjacent to the tumor in mice].

CXCR1 CXCR2

2.73e-06258220082763
Pubmed

The cytomegalovirus UL146 gene product vCXCL1 targets both CXCR1 and CXCR2 as an agonist.

CXCR1 CXCR2

2.73e-06258220044480
Pubmed

CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival.

CXCR1 CXCR2

2.73e-06258226791948
Pubmed

Interleukin-8 in the human fallopian tube.

CXCR1 CXCR2

2.73e-06258211397869
Pubmed

Expression of interleukin-8 receptors in endometriosis.

CXCR1 CXCR2

2.73e-06258215618253
Pubmed

Intracellular cross-talk between the GPCR CXCR1 and CXCR2: role of carboxyl terminus phosphorylation sites.

CXCR1 CXCR2

2.73e-06258217996233
Pubmed

GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier.

GPR89B GPR89A

2.73e-06258222572823
Pubmed

On the mechanism and significance of ligand-induced internalization of human neutrophil chemokine receptors CXCR1 and CXCR2.

CXCR1 CXCR2

2.73e-06258215028716
Pubmed

CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion.

CXCR1 CXCR2

2.73e-06258219401689
Pubmed

Association of interleukin-8 receptor alpha polymorphisms with chronic obstructive pulmonary disease and asthma.

CXCR1 CXCR2

2.73e-06258215772681
Pubmed

A haplotype of the human CXCR1 gene protective against rapid disease progression in HIV-1+ patients.

CXCR1 CXCR2

2.73e-06258217360650
Pubmed

Genetic and functional evaluation of the role of CXCR1 and CXCR2 in susceptibility to visceral leishmaniasis in north-east India.

CXCR1 CXCR2

2.73e-06258222171941
Pubmed

Low expression of CXCR1/2 on neutrophils predicts poor survival in patients with hepatitis B virus-related acute-on-chronic liver failure.

CXCR1 CXCR2

2.73e-06258227974825
Pubmed

Association between interleukin 8-receptor gene (CXCR1 and CXCR2) polymorphisms and urinary tract infection: Evidence from 4097 subjects.

CXCR1 CXCR2

2.73e-06258229577511
Pubmed

Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2.

CXCR1 CXCR2

2.73e-0625828384312
Pubmed

Association of CXCR1 and 2 expressions with gastric cancer metastasis in ex vivo and tumor cell invasion in vitro.

CXCR1 CXCR2

2.73e-06258225022956
Pubmed

Widespread dysregulation of peptide hormone release in mice lacking adaptor protein AP-3.

AP3B1 AP3D1

2.73e-06258224086151
Pubmed

Expression of both types of human interleukin-8 receptors on mature neutrophils, monocytes, and natural killer cells.

CXCR1 CXCR2

2.73e-0625827829970
Pubmed

CXCR1/2 antagonism with CXCL8/Interleukin-8 analogue CXCL8(3-72)K11R/G31P restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis.

CXCR1 CXCR2

2.73e-06258226087179
Pubmed

Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration.

CXCR1 CXCR2

2.73e-06258222152684
Pubmed

[Diagnostic efficiency of determining CXCR1, CXCR2 and hyaluronic acid blood level in non-small cell lung cancer patients].

CXCR1 CXCR2

2.73e-06258234730557
Pubmed

Phagocytosing neutrophils down-regulate the expression of chemokine receptors CXCR1 and CXCR2.

CXCR1 CXCR2

2.73e-06258212239185
Pubmed

Regulation of CXCR/IL-8 in human airway epithelial cells.

CXCR1 CXCR2

2.73e-06258220016196
Pubmed

Expression of CXC receptor 1 and 2 in esophageal mucosa of patients with reflux esophagitis.

CXCR1 CXCR2

2.73e-06258215793866
Pubmed

Human T lymphocytes and mast cells differentially express and regulate extra- and intracellular CXCR1 and CXCR2.

CXCR1 CXCR2

2.73e-06258215265017
Pubmed

CXCR1 and CXCR2 haplotypes synergistically modulate cystic fibrosis lung disease.

CXCR1 CXCR2

2.73e-06258222088968
Pubmed

Repertaxin, an inhibitor of the chemokine receptors CXCR1 and CXCR2, inhibits malignant behavior of human gastric cancer MKN45 cells in vitro and in vivo and enhances efficacy of 5-fluorouracil.

CXCR1 CXCR2

2.73e-06258226847910
Pubmed

GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus.

GPR89B GPR89A

2.73e-06258218794847
Pubmed

Expression of CXCR1 and CXCR2 receptors in malignant melanoma with different metastatic potential and their role in interleukin-8 (CXCL-8)-mediated modulation of metastatic phenotype.

CXCR1 CXCR2

2.73e-06258214713106
Pubmed

Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes.

CXCR1 CXCR2

2.73e-06258227551720
Pubmed

[The role of CXCR1/2 in shear stress-induced endothelial cell migration].

CXCR1 CXCR2

2.73e-06258219634663
Pubmed

Neuronal and non-neuronal functions of the AP-3 sorting machinery.

AP3B1 AP3D1

2.73e-06258217287392
Pubmed

The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse.

AP3B2 AP3B1 AP3D1

3.53e-061858321998198
Pubmed

Towards in situ tissue repair: human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2.

CXCR1 CXCR2

8.19e-06358217295203
Pubmed

CXCR1/2 inhibition enhances pancreatic islet survival after transplantation.

CXCR1 CXCR2

8.19e-06358222996693
Pubmed

Interleukin-8 receptors R1 and R2 activate mitogen-activated protein kinases and induce c-fos, independent of Ras and Raf-1 in Chinese hamster ovary cells.

CXCR1 CXCR2

8.19e-0635829843397
Pubmed

CXCR1 and CXCR2 silencing modulates CXCL8-dependent endothelial cell proliferation, migration and capillary-like structure formation.

CXCR1 CXCR2

8.19e-06358221749879
Pubmed

Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3.

CXCR1 CXCR2

8.19e-06358211196695
Pubmed

Structure and functional expression of a human interleukin-8 receptor.

CXCR1 CXCR2

8.19e-0635821840701
Pubmed

CXCR1 and CXCR2 activation and regulation. Role of aspartate 199 of the second extracellular loop of CXCR2 in CXCL8-mediated rapid receptor internalization.

CXCR1 CXCR2

8.19e-06358217204468
Pubmed

Molecular evolution of the human interleukin-8 receptor gene cluster.

CXCR1 CXCR2

8.19e-0635821303245
Pubmed

Association of single nucleotide polymorphisms in CXCR1, CXCR2 and CXCL5 with Behçet disease: a study in the Denizli province of Turkey.

CXCR1 CXCR2

8.19e-06358234050991
Pubmed

Probing the role of CXC motif in chemokine CXCL8 for high affinity binding and activation of CXCR1 and CXCR2 receptors.

CXCR1 CXCR2

8.19e-06358220630874
Pubmed

Dynamic regulation of CXCR1 and CXCR2 homo- and heterodimers.

CXCR1 CXCR2

8.19e-06358219890050
Pubmed

Genetic variation in interleukin 8 and its receptor genes and its influence on the risk and prognosis of prostate cancer among Finnish men in a large cancer prevention trial.

CXCR1 CXCR2

8.19e-06358216679868
Pubmed

The CXCR1 and CXCR2 receptors form constitutive homo- and heterodimers selectively and with equal apparent affinities.

CXCR1 CXCR2

8.19e-06358215946947
Pubmed

The expression of interleukin-8 and interleukin-8 receptors in endometrial carcinoma.

CXCR1 CXCR2

8.19e-06358222626766
Pubmed

Monomer-dimer equilibria of interleukin-8 and neutrophil-activating peptide 2. Evidence for IL-8 binding as a dimer and oligomer to IL-8 receptor B.

CXCR1 CXCR2

8.19e-0635828195702
Pubmed

Neutrophil chemotaxis caused by chronic obstructive pulmonary disease alveolar macrophages: the role of CXCL8 and the receptors CXCR1/CXCR2.

CXCR1 CXCR2

8.19e-06358223912333
Pubmed

Characterization of two high affinity human interleukin-8 receptors.

CXCR1 CXCR2

8.19e-0635821379593
Pubmed

Analysis of the concentration of CXCL8 chemokine and its CXCR1 and CXCR2 receptors in peritoneal fluid of women with endometriosis.

CXCR1 CXCR2

8.19e-06358236086981
Pubmed

IL-8 gene variants are associated with lung function decline and multidimensional BODE index in COPD patients but not with disease susceptibility: a validation study.

CXCR1 CXCR2

8.19e-06358224946112
Pubmed

The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases.

CXCR1 CXCR2

8.19e-06358224678812
Pubmed

Association between interleukin-8 gene alleles and human susceptibility to tuberculosis disease.

CXCR1 CXCR2

8.19e-06358212870115
Pubmed

Identification of biologically active peptides that inhibit binding of human CXCL8 to its receptors from a random phage-epitope library.

CXCR1 CXCR2

8.19e-06358219118103
Pubmed

Interleukin-8 is related to poor chemotherapeutic response and tumourigenicity in hepatocellular carcinoma.

CXCR1 CXCR2

8.19e-06358224161763
Pubmed

Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.

DRD1 RYR1

8.19e-06358223278119
Pubmed

Inhibition of interleukin 8/C‑X-C chemokine receptor 1,/2 signaling reduces malignant features in human pancreatic cancer cells.

CXCR1 CXCR2

8.19e-06358229749433
Pubmed

The AP-3 complex required for endosomal synaptic vesicle biogenesis is associated with a casein kinase Ialpha-like isoform.

AP3B2 AP3B1

8.19e-06358210930456
Pubmed

A Preliminary Report of the Relationship Between Gene Polymorphism of IL-8 and Its Receptors and Systemic Inflammatory Response Syndrome Caused by Wasp Stings.

CXCR1 CXCR2

8.19e-06358231613654
Pubmed

Variants of the IL8 and IL8RB genes and risk for gastric cardia adenocarcinoma and esophageal squamous cell carcinoma.

CXCR1 CXCR2

8.19e-06358215598788
Pubmed

Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function.

GPR89B GPR89A

8.19e-06358232220963
Pubmed

Characterization of chemokine receptors expressed in primitive blood cells during human hematopoietic ontogeny.

CXCR1 CXCR2

8.19e-06358211007922
Pubmed

The role of interleukin-8 (IL-8) and IL-8 receptors in platinum response in high grade serous ovarian carcinoma.

CXCR1 CXCR2

8.19e-06358226267317
Pubmed

VPS35 regulates cell surface recycling and signaling of dopamine receptor D1.

DRD1 VPS35

8.19e-06358227460146
Pubmed

[Influence of IFN on expression of chemokine receptor CXCR1, CXCR2 and their ligand IL-8 in the patients with chronic hepatitis B].

CXCR1 CXCR2

8.19e-06358222482416
Pubmed

Club cell protein 16 in sera from trauma patients modulates neutrophil migration and functionality via CXCR1 and CXCR2.

CXCR1 CXCR2

8.19e-06358231666007
Pubmed

CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study.

CXCR1 CXCR2

8.19e-06358220089160
Pubmed

Synergistic interactions between chemokine receptor elements in recognition of interleukin-8 by soluble receptor mimics.

CXCR1 CXCR2

8.19e-06358222242662
Pubmed

Cell migration to the chemokine CXCL8: paxillin is activated and regulates adhesion and cell motility.

CXCR1 CXCR2

8.19e-06358219151925
Pubmed

The neuronal form of adaptor protein-3 is required for synaptic vesicle formation from endosomes.

AP3B1 AP3D1

8.19e-06358211588176
Pubmed

The CXCL8-CXCR1/2 pathways in cancer.

CXCR1 CXCR2

8.19e-06358227578214
Pubmed

Association of interleukin 8 with myocardial infarction: results from the Stockholm Heart Epidemiology Program.

CXCR1 CXCR2

8.19e-06358224462138
Pubmed

Genetic variations of interleukin-8, CXCR1 and CXCR2 genes and risk of acute pyelonephritis in children.

CXCR1 CXCR2

8.19e-06358222325052
Pubmed

IL-8/CXCR1/2 signalling promotes tumor cell proliferation, invasion and vascular mimicry in glioblastoma.

CXCR1 CXCR2

8.19e-06358230086759
Pubmed

The antagonist of CXCR1 and CXCR2 protects db/db mice from metabolic diseases through modulating inflammation.

CXCR1 CXCR2

8.19e-06358231573846
InteractionBPIFB1 interactions

LRRC8E PTPN14 PIK3CA PTPN21 TRRAP

3.26e-0753555int:BPIFB1
Cytoband2q35

TMBIM1 CXCR1 CXCR2

1.41e-04795832q35
Cytoband1q31

ASPM PFKFB2

2.65e-04195821q31
CytobandEnsembl 112 genes in cytogenetic band chr2q35

TMBIM1 CXCR1 CXCR2

5.97e-04129583chr2q35
Cytoband1q21.1

GPR89B GPR89A

2.83e-03625821q21.1
GeneFamilyCD molecules|C-X-C motif chemokine receptors

CXCR1 CXCR2

6.76e-0563921094
GeneFamilyCD molecules|I-set domain containing|Immunoglobulin like domain containing|Interleukin receptors|TIR domain containing

IL1RL2 CXCR1 CXCR2

1.01e-0442393602
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

PTPN14 MYO10 PTPN21

1.70e-04503931293
GeneFamilyG protein-coupled receptors, Class A orphans

GPR18 GPR19 GPR141

6.31e-0478393262
GeneFamilyProtein tyrosine phosphatases, non-receptor type

PTPN14 PTPN21

6.79e-0418392812
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

INPP4A CADPS2

2.73e-0336392823
ToppCellPBMC-Mild-Myeloid-Neutrophil-Neutrophil-Neu_0|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LRRC8E ADGRG2 TRIM64C CXCR1 CXCR2

8.15e-07132585fe87cb22e13e17df29ad43327f1aa71361907582
ToppCellPBMC-Mild-Myeloid-Neutrophil-Neutrophil-Neu_0|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LRRC8E ADGRG2 TRIM64C CXCR1 CXCR2

8.15e-0713258582f312a561d9fdd2ebc2c25926dfc2b333ff0a4f
ToppCelldroplet-Skin-nan-21m-Epithelial-stem_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HAUS4 ERCC6L ASPM DNAH8 NCAPG2

5.12e-0619258596f23d6e8604d1cb24910d3118d8171b57c93e14
ToppCellLPS_IL1RA-Endothelial-Endothelial-FOXM1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MMS22L ADGRG2 ERCC6L ASPM NCAPG2

6.10e-06199585be2276c9a1994579ba1d2998b49bf549c1324d44
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma-5|TCGA-Endometrium / Sample_Type by Project: Shred V9

GPR19 PIK3CA TECTA ELOVL2

5.23e-0515758459450e9f580555091b159fbbe0a0756e51bcd9ad
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENDOD1 CCDC88A ASPM GPR141

5.91e-0516258493bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCellLPS-antiTNF-Endothelial-Endothelial-FOXM1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MMS22L ERCC6L ASPM NCAPG2

6.05e-051635845285318c52aa31c9b22dc2ffff078e32e408604d
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Crh_(MGE-derived_cortical_interneurons--Martinotti_cells)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SLC46A2 PCDHB1 DNASE1

6.94e-0561583351078cb41e285af7e117820ee607d4c24332a9d
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Crh_(MGE-derived_cortical_interneurons--Martinotti_cells)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SLC46A2 PCDHB1 DNASE1

6.94e-0561583aae9ba2240812258d1c9e0e443d4f817b4796131
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-FOXM1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MMS22L ERCC6L ASPM NCAPG2

6.96e-05169584e0607af8ae8609d43e26ff2a2cab92650bfcd5b7
ToppCelldroplet-Lung-nan-3m-Lymphocytic-T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMS22L HAUS4 ERCC6L ASPM

6.96e-05169584df2c9c706bfc9db2bc5726602a49f5f5a94e9481
ToppCellInfluenza_Severe-Neutrophil|World / Disease group and Cell class

TDRD9 PFKFB2 CXCR1 CXCR2

6.96e-051695846e8e2580e19c96bcf7fa6a6d8c183df65f428396
ToppCelldroplet-Lung-nan-3m-Lymphocytic-Proliferating_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMS22L HAUS4 ERCC6L ASPM

6.96e-05169584f6a6d2f614d60395ad9b867ff1cf59eba72b04ce
ToppCellDividing_Macrophages-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

CCDC88A ERCC6L ASPM NCAPG2

6.96e-05169584bc859a103cad567caf50c3c3882d2d2017807c73
ToppCell10x5'-Lung-Lymphocytic_T_CD4/8-lo-Cycling_T|Lung / Manually curated celltypes from each tissue

GPR19 ERCC6L ASPM NCAPG2

7.28e-05171584976361f67dd725870e0513ae7a92f2dcaee17148
ToppCellsevere_influenza-Neutrophil|World / disease group, cell group and cell class (v2)

AP3B2 PFKFB2 CXCR1 CXCR2

7.79e-05174584f9f07436b7d3f190800cd85d229f007032f391e1
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HAUS4 GPR19 ASPM NCAPG2

7.79e-0517458472df66319f6efbd88ecf439013d97409fbf3cb52
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HAUS4 GPR19 ASPM NCAPG2

7.79e-05174584c6087fd0e036ec7f40f0f8f17d1f6ce13ddb5235
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC88A ERCC6L ASPM CXCR1

7.79e-0517458465147b0f8c2ccadd5685430d31081520c157536a
ToppCelldroplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP13A4 PIK3CA ANO6 PTGIS

8.14e-051765848e89471f838ea81235256cc2470f1c12c9b75f8a
ToppCellTCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma-1|TCGA-Adrenal / Sample_Type by Project: Shred V9

TRHDE INPP4A AP3B2 PTGIS

8.69e-05179584431e1b29015ec817f778499106d24b19cfc825ae
ToppCelldroplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____thick_ascending_tube_S_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMS22L GPR19 ASPM NCAPG2

8.69e-051795844166c4e1a8748a79ac6a11fd0b97c5344be2321b
ToppCellLPS-IL1RA-Endothelial-Endothelial-FOXM1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MMS22L ERCC6L ASPM NCAPG2

8.88e-05180584334e2b1f6eb7d4ece20b1c7b02107863f913237f
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-Proliferating_T_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MMS22L ERCC6L ASPM NCAPG2

9.07e-05181584cf13bf7a531a2d40f8d778629cf2431b684f65f3
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MMS22L ERCC6L ASPM NCAPG2

9.07e-0518158474311aac2fe27dc02a9be3bc20e0c7ef1c239049
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D175|Adult / Lineage, Cell type, age group and donor

ATP13A4 PTPN14 ANO6 PTPN21

9.87e-0518558432b4e68e551d435a732f253f6ad83408c759a642
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CCDC168|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRHDE PFKFB2 CADPS2 PTGIS

9.87e-051855845a0340c25196453f19e424d346efbf66d2c53ac3
ToppCellfacs-Skin-Telogen-3m-Epithelial-actively_dividing_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HAUS4 ERCC6L ASPM DNAH8

1.01e-041865849feef5936985e936b3d88f9d1bb012abb6468570
ToppCellfacs-Skin-Telogen-3m-Epithelial-keratinocyte_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HAUS4 ERCC6L ASPM DNAH8

1.01e-0418658489f5b06bc56674af304912d481ac697c7c870904
ToppCellsevere_influenza-B_intermediate|severe_influenza / disease group, cell group and cell class (v2)

GPR18 CHST6 SNX9 DNAH8

1.03e-04187584d6db8595aa72fdabc4a056ba6ce09876868a66d5
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CCDC88A ASPM NCAPG2 RYR1

1.03e-0418758473931a5ea73799095daff100b5f18853c57c74dc
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERCC6L ASPM NCAPG2 CXCR1

1.05e-04188584319fbeca200ab998daf49fcaee0bfdb57bf7ee4b
ToppCellfacs-Skin-Anagen-3m-Epithelial-actively_dividing_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMS22L ERCC6L ASPM NCAPG2

1.07e-04189584bfa3ed1360991a3e32fad133017c413f8adc1eba
ToppCellfacs-Skin-Anagen-3m-Epithelial-keratinocyte_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMS22L ERCC6L ASPM NCAPG2

1.07e-0418958496f10c63656e446b4bb712f012e91ae986f8c2d0
ToppCellPBMC-Mild-cDC_12|Mild / Compartment, Disease Groups and Clusters

ERCC6L ASPM NCAPG2 CXCR1

1.07e-04189584946c95d2ecc36b241f58e8c4ad6455fe47c762fa
ToppCellControl-Endothelial-Endothelial-FOXM1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MMS22L ERCC6L ASPM NCAPG2

1.07e-041895841e1499b062d9c647c8f38b0c4e0d871d159be5dd
ToppCelldroplet-Spleen-nan-18m-Lymphocytic-immature_NKT_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERCC6L ASPM DNAH8 NCAPG2

1.09e-04190584b99271d139c8d01e20feb95d99f79c9b2756b4cb
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MMS22L ERCC6L ASPM NCAPG2

1.12e-0419158415dbc5a03bfab8931c0fd385b0f25874736ae874
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-Proliferating_T_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MMS22L ERCC6L ASPM NCAPG2

1.12e-0419158445c15f5ce4a207ac944bed65d45f06c1657d1a6d
ToppCellfacs-Thymus-Flowthrough-3m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMS22L ERCC6L ASPM NCAPG2

1.14e-04192584e8d47504b744040a762ec9b670a66cc060b2ae86
ToppCelldroplet-Tongue-nan-24m-Epithelial-proliferating|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HAUS4 ERCC6L ASPM NCAPG2

1.16e-04193584f20b90e3f3f5c9a1ae51c5ebe6d3adb954a142f2
ToppCelldroplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MMS22L ERCC6L ASPM NCAPG2

1.21e-04195584c1435e61e4f0cf457f26ae436936048932ceb0db
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Proliferating-Cycling_Progenitors|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

MMS22L ERCC6L ASPM NCAPG2

1.23e-041965845905f0e3061a6b98b7a33d64c782c3dda2cd51ef
ToppCellmild-pDC|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CCDC88A TAS2R40 PFKFB2 ELOVL2

1.26e-041975840cb00daa6943f7a7fb34a8fdf51188646af65686
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERCC6L ASPM PTGIS NCAPG2

1.26e-0419758476b61e60a757e58b465569538e632d6d9953e89a
ToppCellLPS_only-Endothelial-Endothelial-FOXM1|LPS_only / Treatment groups by lineage, cell group, cell type

ERCC6L ASPM NCAPG2 RYR1

1.26e-04197584038fd92750257d43d5e980fd06d77742b543f11a
ToppCellmild-pDC|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CCDC88A TAS2R40 PFKFB2 ELOVL2

1.26e-0419758415230a54fa5903dd728de1a0ad633bd2d2c7a04d
ToppCelldistal-Hematologic-Proliferating_NK/T-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GPR19 ERCC6L ASPM NCAPG2

1.28e-041985845c14b152912429f099dfcb6bcb1aec80314a3284
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CCDC88A TDRD9 ASPM RYR1

1.28e-041985842b724d2a36843801984d46a969d33149b76c9771
ToppCellsevere-Myeloid-Neutrophils_4|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

TDRD9 PFKFB2 CXCR1 CXCR2

1.31e-0419958450242666def13e5d4149c563ae000d6768f086f7
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

GPR19 ERCC6L ASPM NCAPG2

1.31e-04199584c6d59ed26eadd3c41acfe1b4d929270e00ea3e95
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-FOXM1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

CCDC88A ERCC6L ASPM NCAPG2

1.33e-042005844cfe08878a6981bf7b3567f9e82192d8f060ddde
ToppCellmedial-Hematologic-Proliferating_NK/T-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GPR19 ERCC6L ASPM NCAPG2

1.33e-04200584ab1f9f99cb4a381a642a2cfb32e7f8d276c2dda4
ToppCellControl_saline-Endothelial-Endothelial-FOXM1|Control_saline / Treatment groups by lineage, cell group, cell type

CCDC88A ERCC6L ASPM NCAPG2

1.33e-042005849bbc7b5561151f6ff65f40b3226271def732e5d9
ToppCellsevere-Myeloid-Neutrophils_4|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

TDRD9 PFKFB2 CXCR1 CXCR2

1.33e-04200584b665f36dcf3c9d3981ee96f2973512f751612542
ToppCellSepsis-URO-Lymphocyte-T/NK-T/NK_proliferative|URO / Disease, condition lineage and cell class

MMS22L ERCC6L ASPM NCAPG2

1.33e-04200584f277db6cc288a52a5426120c1067608700ee8ccc
ToppCellmedial-Hematologic-Proliferating_NK/T|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GPR19 ERCC6L ASPM NCAPG2

1.33e-04200584bfde42e00a9a6b858937de87cd19c9ed3677d954
ToppCellmedial-2-Hematologic-Proliferating_NK/T|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GPR19 ERCC6L ASPM NCAPG2

1.33e-042005843d1895490dd262e9246eb280938239a7253451dd
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Parm1-Excitatory_Neuron.Slc17a7.Parm1.Fos_(Deep_layer_pyramidal_cells--layer_5_(IEG))|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MMS22L DNASE1 IQUB

1.39e-04775834879a1a72b950dadb78bc0312be75f1a32b935d5
ComputationalGenes in the cancer module 571.

DRD1 GPR18 PTPN21

7.86e-0615293MODULE_571
Drugdiaminocyclobut-3-ene-1,2-dione

CXCR1 CXCR2

1.84e-053572CID002781329
Drug5-methoxysalicylaldehyde

CXCR1 CXCR2

1.84e-053572CID000095695
Drug3-chloropropanoyl chloride

RYR1 CXCR1

1.84e-053572CID000069364
DrugDTTA

CXCR1 CXCR2

1.84e-053572CID000166909
DrugIonophores

CXCR1 CXCR2

1.84e-053572ctd:D007476
Drugdimethylcyclohexane

CXCR1 CXCR2

1.84e-053572CID000011549
Drugnitroethylene

CXCR1 CXCR2

3.68e-054572CID000077197
Drugdeltorphin II, Ala(2)-

CXCR1 CXCR2

3.68e-054572ctd:C060209
DiseaseHermansky-Pudlak syndrome 2 (implicated_via_orthology)

AP3B1 AP3D1

3.67e-062572DOID:0060540 (implicated_via_orthology)
DiseaseHermansky-Pudlak syndrome (is_implicated_in)

AP3B1 AP3D1

7.65e-057572DOID:3753 (is_implicated_in)
DiseaseHermanski-Pudlak Syndrome

AP3B1 AP3D1

1.63e-0410572C0079504
DiseaseHermansky-Pudlak syndrome

AP3B1 AP3D1

1.63e-0410572cv:C0079504
Diseaseplatelet storage pool deficiency (implicated_via_orthology)

AP3B1 AP3D1

3.79e-0415572DOID:2223 (implicated_via_orthology)
DiseaseFetal Alcohol Syndrome

ERCC6L PIK3CA

4.89e-0417572C0015923
DiseaseParkinson Disease

DRD1 VPS35 NCAPG2

6.03e-0485573C0030567
Diseasenon-alcoholic fatty liver disease severity measurement

DRD1 DNASE1

1.34e-0328572EFO_0008421
DiseasePigmented Basal Cell Carcinoma

PTPN14 PIK3CA

1.34e-0328572C1368275
DiseaseCarcinoma, Basal Cell

PTPN14 PIK3CA

1.44e-0329572C4721806

Protein segments in the cluster

PeptideGeneStartEntry
IFNEYILKQVATTYI

TRHDE

776

Q9UKU6
IIFKIYYFNNVDVIS

nan

616

A8MVM7
LVNRVQDYIQSKIVY

PFKFB2

226

O60825
TYTNYIFVLVLIIQL

ATP13A4

1066

Q4VNC1
YYIVSKQFQARVISV

GPR18

286

Q14330
SVLIILFYQKVIKYI

GPR19

236

Q15760
LALVKVFNTYIRKYI

ADGRG2

721

Q8IZP9
IVTYTRIYRIAQKQI

DRD1

211

P21728
LRKYIYIRSCVVIIQ

ASPM

1481

Q8IZT6
KKTAIVVIQNYYRLY

ASPM

2711

Q8IZT6
VVIQNYYRLYVRVKT

ASPM

2716

Q8IZT6
NIEIKKLVYVYLVRY

AP3B1

91

O00203
NIEVKKLVYVYLVRY

AP3B2

86

Q13367
VYVQNVVKLYASILQ

AP3D1

521

O14617
LYNIRQYEVFLQIIL

CFAP206

266

Q8IYR0
LVTYTNRYIIFKRNT

GMCL1

421

Q96IK5
TYVKIINYMIVIFVI

GPR141

176

Q7Z602
RRQIVTQYQTIILTY

INPP4A

291

Q96PE3
VIVIFIIHVYQKIKY

PCDHB1

706

Q9Y5F3
IVYFILSRVKYQVIN

ANO6

211

Q4KMQ2
QIYTDIIYIFTFVLQ

TMBIM1

291

Q969X1
YVKVFIFRYLKVQNA

MMS22L

136

Q6ZRQ5
VKCIFRIQYEEVLYI

ATAD2B

881

Q9ULI0
IYYLVVAILKNIVYF

ENDOD1

346

O94919
ILVRQIKFYYQETLQ

CCDC88A

81

Q3V6T2
INKYFVVIIYALVFL

CXCR2

46

P25025
KRITNIIEYLTYEVF

DNAH8

3731

Q96JB1
QYRKVLYCVVIIQKN

MYO10

761

Q9HD67
FLAILVYNLVYVEKI

LRRC8E

266

Q6NSJ5
IQIFTIVLVSYFYIL

OR5K3

206

A6NET4
QRILQLRTVTEKIYY

GARIN1B

161

Q96KD3
QIENVLRRYIKEYVT

EIF2S2

266

P20042
YLIQLVQVLKYEQYL

PIK3CA

631

P42336
VQTLCQYTFVYRVLI

PTPN21

1151

Q16825
QYTFVYRVLIQFLKS

PTPN21

1156

Q16825
SVVYIYNIFKIDIVL

IL1RL2

351

Q9HB29
KDYEIRQYVVQVIFS

GPR89A

31

B7ZAQ6
KDYEIRQYVVQVIFS

GPR89B

31

P0CG08
VILFLNFYVQTYRKK

ELOVL2

246

Q9NXB9
YIVQILSRYDIALVQ

DNASE1

46

P24855
TLNKYVVIIAYALVF

CXCR1

36

P25024
KKRYFVLVQVSQYTF

CADPS2

506

Q86UW7
AQRLKAVIVIQTYYR

IQUB

336

Q8NA54
RVIQELLVDYYVKIQ

HAUS4

86

Q9H6D7
KIVRRVQEVSAVLYY

RYR1

3591

P21817
YRIGQKENVVVYRLI

ERCC6L

571

Q2NKX8
IVYNQNSVYILFKVI

TAS2R40

86

P59535
VIRLYLEQQVQFYET

SNX9

566

Q9Y5X1
EYIYKQRFILQVVLA

TDRD9

731

Q8NDG6
YAVNSIKQFVFLVLV

PTGIS

446

Q16647
TIAQYKFVYQVLIQF

PTPN14

1166

Q15678
VVLKEVRFFNLQVLY

CHST6

171

Q9GZX3
NIVTVTIIIFYQKAR

CLRN3

191

Q8NCR9
TIIIFYQKARYQRKQ

CLRN3

196

Q8NCR9
KLHRVIYQQIIQTYL

NCAPG2

871

Q86XI2
IQIYYNGFNVIKISI

TECTA

1596

O75443
IRSVLSQQAYVLFYI

USP42

396

Q9H9J4
QVQLFIEILNRYIYF

VPS35

716

Q96QK1
DQILIRTTQIYTYFV

SEC63

221

Q9UGP8
QRAISNFYIIYNLVV

SLC46A2

71

Q9BY10
YVSLRKVIITIQYQK

TRIM64C

171

A6NLI5
LAYIIRIYQELVTKY

TRRAP

291

Q9Y4A5
VYNINKITRIYNVVG

NAALAD2

336

Q9Y3Q0