Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	bicarbonate channel activity	BEST2 BEST4	2.15e-05	3	54	2	GO:0160133
GeneOntologyMolecularFunction	transporter activity	GRAMD1B SLC38A9 BEST2 SCN2A BEST4 GRAMD1A SCN8A SLC19A2 SLC15A3 GRM7 DMAC2L TMC3 ABCA10	2.92e-05	1289	54	13	GO:0005215
GeneOntologyMolecularFunction	protein-cysteine S-palmitoyltransferase activity	ZDHHC11B ZDHHC11 ZDHHC4	4.65e-05	26	54	3	GO:0019706
GeneOntologyMolecularFunction	protein-cysteine S-acyltransferase activity	ZDHHC11B ZDHHC11 ZDHHC4	4.65e-05	26	54	3	GO:0019707
GeneOntologyMolecularFunction	S-acyltransferase activity	ZDHHC11B ZDHHC11 ZDHHC4	7.21e-05	30	54	3	GO:0016417
GeneOntologyMolecularFunction	olfactory receptor binding	RTP3 RTP4	1.07e-04	6	54	2	GO:0031849
GeneOntologyMolecularFunction	palmitoyltransferase activity	ZDHHC11B ZDHHC11 ZDHHC4	1.36e-04	37	54	3	GO:0016409
GeneOntologyMolecularFunction	amide transmembrane transporter activity	SLC38A9 SLC19A2 SLC15A3	1.99e-04	42	54	3	GO:0042887
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC38A9 BEST2 SCN2A BEST4 SCN8A SLC19A2 SLC15A3 GRM7 DMAC2L TMC3 ABCA10	2.67e-04	1180	54	11	GO:0022857
GeneOntologyMolecularFunction	cholesterol binding	GRAMD1B SLC38A9 GRAMD1A	5.19e-04	58	54	3	GO:0015485
GeneOntologyMolecularFunction	sodium ion binding	SCN2A SCN8A	6.40e-04	14	54	2	GO:0031402
GeneOntologyMolecularFunction	sterol binding	GRAMD1B SLC38A9 GRAMD1A	9.38e-04	71	54	3	GO:0032934
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	BEST2 SCN2A BEST4 SCN8A SLC15A3 GRM7 DMAC2L TMC3	1.23e-03	793	54	8	GO:0015075
GeneOntologyMolecularFunction	monoatomic ion channel activity	BEST2 SCN2A BEST4 SCN8A GRM7 TMC3	1.45e-03	459	54	6	GO:0005216
GeneOntologyMolecularFunction	cholesterol transfer activity	GRAMD1B GRAMD1A	1.91e-03	24	54	2	GO:0120020
GeneOntologyMolecularFunction	gated channel activity	BEST2 SCN2A BEST4 GRM7 TMC3	2.05e-03	334	54	5	GO:0022836
GeneOntologyMolecularFunction	sterol transfer activity	GRAMD1B GRAMD1A	2.07e-03	25	54	2	GO:0120015
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN2A SCN8A	2.24e-03	26	54	2	GO:0005248
GeneOntologyMolecularFunction	alkali metal ion binding	SCN2A SCN8A	2.24e-03	26	54	2	GO:0031420
GeneOntologyMolecularFunction	alcohol binding	GRAMD1B SLC38A9 GRAMD1A	2.66e-03	102	54	3	GO:0043178
GeneOntologyMolecularFunction	channel activity	BEST2 SCN2A BEST4 SCN8A GRM7 TMC3	2.85e-03	525	54	6	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	BEST2 SCN2A BEST4 SCN8A GRM7 TMC3	2.87e-03	526	54	6	GO:0022803
GeneOntologyMolecularFunction	bicarbonate transmembrane transporter activity	BEST2 BEST4	3.38e-03	32	54	2	GO:0015106
GeneOntologyMolecularFunction	acyltransferase activity, transferring groups other than amino-acyl groups	ZDHHC11B ZDHHC11 CLOCK ZDHHC4	3.90e-03	238	54	4	GO:0016747
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	BEST2 SCN2A BEST4 SCN8A SLC15A3 GRM7 DMAC2L	4.14e-03	758	54	7	GO:0015318
GeneOntologyMolecularFunction	metalloendopeptidase activity	MBTPS2 ADAM18 MMP21	4.20e-03	120	54	3	GO:0004222
GeneOntologyMolecularFunction	steroid binding	GRAMD1B SLC38A9 GRAMD1A	5.59e-03	133	54	3	GO:0005496
GeneOntologyBiologicalProcess	protein targeting	RTP3 VPS13D ZDHHC11B SYNGR2 SYNGR1 ZDHHC11 ZDHHC4 RTP4	6.15e-06	373	55	8	GO:0006605
GeneOntologyBiologicalProcess	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	ZDHHC11B ZDHHC11 ZDHHC4	3.49e-05	24	55	3	GO:0018231
GeneOntologyBiologicalProcess	peptidyl-L-cysteine S-palmitoylation	ZDHHC11B ZDHHC11 ZDHHC4	3.49e-05	24	55	3	GO:0018230
GeneOntologyBiologicalProcess	protein targeting to membrane	RTP3 ZDHHC11B ZDHHC11 ZDHHC4 RTP4	4.78e-05	149	55	5	GO:0006612
GeneOntologyBiologicalProcess	protein palmitoylation	ZDHHC11B ZDHHC11 ZDHHC4	9.25e-05	33	55	3	GO:0018345
GeneOntologyBiologicalProcess	protein acylation	ZDHHC11B ZDHHC11 CLOCK ZDHHC4	1.97e-04	108	55	4	GO:0043543
GeneOntologyCellularComponent	CLOCK-BMAL transcription complex	CLOCK NPAS2	6.76e-05	5	55	2	GO:1990513
GeneOntologyCellularComponent	exocytic vesicle membrane	SYNGR3 SYNGR2 SYNGR1 SYPL2 SYNGR4	1.07e-04	179	55	5	GO:0099501
GeneOntologyCellularComponent	synaptic vesicle membrane	SYNGR3 SYNGR2 SYNGR1 SYPL2 SYNGR4	1.07e-04	179	55	5	GO:0030672
GeneOntologyCellularComponent	neuromuscular junction	SYNGR3 SYNGR2 SYNGR1 SYNGR4	2.16e-04	112	55	4	GO:0031594
GeneOntologyCellularComponent	presynapse	ADRA1A SCN2A SYNGR3 SYNGR2 SYNGR1 SCN8A SYPL2 GRM7 SYNGR4	4.67e-04	886	55	9	GO:0098793
GeneOntologyCellularComponent	endoplasmic reticulum-plasma membrane contact site	GRAMD1B GRAMD1A	5.20e-04	13	55	2	GO:0140268
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN2A SCN8A	9.01e-04	17	55	2	GO:0001518
GeneOntologyCellularComponent	transport vesicle membrane	SYNGR3 SYNGR2 SYNGR1 SYPL2 SYNGR4	1.03e-03	293	55	5	GO:0030658
GeneOntologyCellularComponent	synaptic vesicle	SYNGR3 SYNGR2 SYNGR1 SYPL2 SYNGR4	1.14e-03	300	55	5	GO:0008021
GeneOntologyCellularComponent	node of Ranvier	SCN2A SCN8A	1.25e-03	20	55	2	GO:0033268
GeneOntologyCellularComponent	exocytic vesicle	SYNGR3 SYNGR2 SYNGR1 SYPL2 SYNGR4	1.52e-03	320	55	5	GO:0070382
GeneOntologyCellularComponent	axon initial segment	SCN2A SCN8A	2.64e-03	29	55	2	GO:0043194
GeneOntologyCellularComponent	sodium channel complex	SCN2A SCN8A	2.64e-03	29	55	2	GO:0034706
GeneOntologyCellularComponent	monoatomic ion channel complex	BEST2 SCN2A BEST4 SCN8A DMAC2L	3.12e-03	378	55	5	GO:0034702
HumanPheno	Focal head nodding automatism seizure	SCN2A SCN8A	6.98e-05	5	14	2	HP:0032906
HumanPheno	Neonatal electro-clinical non-motor seizure	SCN2A SCN8A	6.98e-05	5	14	2	HP:0032812
HumanPheno	Neonatal seizure with electrographic correlate	SCN2A SCN8A	6.98e-05	5	14	2	HP:0032808
HumanPheno	Neonatal electro-clinical seizure	SCN2A SCN8A	6.98e-05	5	14	2	HP:0032809
HumanPheno	Neonatal electro-clinical seizure with behavior arrest	SCN2A SCN8A	6.98e-05	5	14	2	HP:0032823
HumanPheno	Generalized clonic seizure	SCN2A SCN8A GRM7	9.41e-05	34	14	3	HP:0011169
HumanPheno	Normal interictal EEG	SCN2A SCN8A	1.05e-04	6	14	2	HP:0002372
HumanPheno	Eyelid myoclonia seizure	SCN2A SCN8A	1.46e-04	7	14	2	HP:0032678
HumanPheno	Abnormality of the ureter	FREM2 MBTPS2 SCN2A CHD4 GRM7 ZMYM3	3.10e-04	383	14	6	HP:0000069
HumanPheno	Neonatal seizure	SCN2A SCN8A	3.80e-04	11	14	2	HP:0032807
MousePheno	increased circulating glucose level	AFMID FARP1 PDP1 CLDND2 SYNGR2 OAS1 FGL1 KBTBD2 FTO CLOCK	7.90e-06	553	45	10	MP:0005559
Domain	Synaptogyrin	SYNGR3 SYNGR2 SYNGR1 SYNGR4	6.24e-11	4	54	4	IPR016579
Domain	MARVEL	SYNGR3 SYNGR2 SYNGR1 SYPL2 SYNGR4	1.29e-08	27	54	5	PF01284
Domain	Marvel	SYNGR3 SYNGR2 SYNGR1 SYPL2 SYNGR4	1.56e-08	28	54	5	IPR008253
Domain	MARVEL	SYNGR3 SYNGR2 SYNGR1 SYPL2 SYNGR4	1.56e-08	28	54	5	PS51225
Domain	VAST	GRAMD1B GRAMD1A	2.46e-05	3	54	2	PS51778
Domain	DUF4782	GRAMD1B GRAMD1A	2.46e-05	3	54	2	IPR031968
Domain	DUF4782	GRAMD1B GRAMD1A	2.46e-05	3	54	2	PF16016
Domain	Bestrophin/UPF0187	BEST2 BEST4	4.90e-05	4	54	2	IPR021134
Domain	Bestrophin	BEST2 BEST4	4.90e-05	4	54	2	IPR000615
Domain	Bestrophin	BEST2 BEST4	4.90e-05	4	54	2	PF01062
Domain	R-trans_p	RTP3 RTP4	8.16e-05	5	54	2	IPR026096
Domain	Na_trans_cytopl	SCN2A SCN8A	1.22e-04	6	54	2	PF11933
Domain	Na_trans_cytopl	SCN2A SCN8A	1.22e-04	6	54	2	IPR024583
Domain	zf-3CxxC	RTP3 RTP4	1.71e-04	7	54	2	PF13695
Domain	zf-3CxxC	RTP3 RTP4	2.27e-04	8	54	2	SM01328
Domain	Znf-3CxxC	RTP3 RTP4	2.27e-04	8	54	2	IPR027377
Domain	Nuc_translocat	CLOCK NPAS2	2.27e-04	8	54	2	IPR001067
Domain	Na_channel_asu	SCN2A SCN8A	3.64e-04	10	54	2	IPR001696
Domain	Na_trans_assoc	SCN2A SCN8A	3.64e-04	10	54	2	IPR010526
Domain	Na_trans_assoc	SCN2A SCN8A	3.64e-04	10	54	2	PF06512
Domain	GRAM	GRAMD1B GRAMD1A	9.59e-04	16	54	2	SM00568
Domain	Gal_mutarotase_SF_dom	BEST2 BEST4	1.09e-03	17	54	2	IPR011013
Domain	Fibrinogen_CS	FCN2 FGL1	1.36e-03	19	54	2	IPR020837
Domain	GRAM	GRAMD1B GRAMD1A	1.83e-03	22	54	2	PF02893
Domain	GRAM	GRAMD1B GRAMD1A	1.83e-03	22	54	2	IPR004182
Domain	PAS_fold_3	CLOCK NPAS2	2.00e-03	23	54	2	IPR013655
Domain	PAS_3	CLOCK NPAS2	2.00e-03	23	54	2	PF08447
Domain	zf-DHHC	ZDHHC11 ZDHHC4	2.00e-03	23	54	2	PF01529
Domain	Fibrinogen_a/b/g_C_2	FCN2 FGL1	2.17e-03	24	54	2	IPR014715
Domain	-	FCN2 FGL1	2.17e-03	24	54	2	4.10.530.10
Domain	PAS	CLOCK NPAS2	2.36e-03	25	54	2	PF00989
Domain	PAS_fold	CLOCK NPAS2	2.36e-03	25	54	2	IPR013767
Domain	DHHC	ZDHHC11 ZDHHC4	2.36e-03	25	54	2	PS50216
Domain	Znf_DHHC_palmitoyltrfase	ZDHHC11 ZDHHC4	2.36e-03	25	54	2	IPR001594
Domain	PAC	CLOCK NPAS2	2.55e-03	26	54	2	IPR001610
Domain	PAC	CLOCK NPAS2	2.55e-03	26	54	2	SM00086
Domain	PAC	CLOCK NPAS2	2.55e-03	26	54	2	PS50113
Domain	Fibrinogen_C	FCN2 FGL1	2.75e-03	27	54	2	PF00147
Domain	FBG	FCN2 FGL1	3.17e-03	29	54	2	SM00186
Domain	-	FCN2 FGL1	3.39e-03	30	54	2	3.90.215.10
Domain	Fibrinogen_a/b/g_C_1	FCN2 FGL1	3.39e-03	30	54	2	IPR014716
Domain	FIBRINOGEN_C_1	FCN2 FGL1	3.85e-03	32	54	2	PS00514
Domain	Fibrinogen_a/b/g_C_dom	FCN2 FGL1	3.85e-03	32	54	2	IPR002181
Domain	PAS	CLOCK NPAS2	3.85e-03	32	54	2	SM00091
Domain	FIBRINOGEN_C_2	FCN2 FGL1	3.85e-03	32	54	2	PS51406
Domain	PAS	CLOCK NPAS2	4.34e-03	34	54	2	IPR000014
Domain	PAS	CLOCK NPAS2	4.34e-03	34	54	2	PS50112
Pubmed	Characterization of the human synaptogyrin gene family.	SYNGR3 SYNGR2 SYNGR1 SYNGR4	2.79e-11	5	55	4	9760194
Pubmed	ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma.	ZDHHC11B ZDHHC11	2.46e-06	2	55	2	28331227
Pubmed	Sodium channel expression within chronic multiple sclerosis plaques.	SCN2A SCN8A	2.46e-06	2	55	2	17805013
Pubmed	Commonalities and distinctions between two neurodevelopmental disorder subtypes associated with SCN2A and SCN8A variants and literature review.	SCN2A SCN8A	2.46e-06	2	55	2	35348308
Pubmed	Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.	SCN2A SCN8A	2.46e-06	2	55	2	15760941
Pubmed	Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cells.	BEST2 BEST4	2.46e-06	2	55	2	24223998
Pubmed	Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.	SCN2A SCN8A	2.46e-06	2	55	2	18601978
Pubmed	FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.	SCN2A SCN8A	2.46e-06	2	55	2	19465131
Pubmed	Genetic loci for blood lipid levels identified by linkage and association analyses in Caribbean Hispanics.	ZNF343 TMC3	2.46e-06	2	55	2	21558551
Pubmed	Association between restless legs syndrome and CLOCK and NPAS2 gene polymorphisms in schizophrenia.	CLOCK NPAS2	2.46e-06	2	55	2	24824748
Pubmed	Testis-specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization.	ZDHHC11B ZDHHC11	2.46e-06	2	55	2	35384384
Pubmed	Aster Proteins Regulate the Accessible Cholesterol Pool in the Plasma Membrane.	GRAMD1B GRAMD1A	2.46e-06	2	55	2	32719109
Pubmed	Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis.	SCN2A SCN8A	2.46e-06	2	55	2	23735284
Pubmed	Characterization of synaptogyrin 3 as a new synaptic vesicle protein.	SYNGR3 SYNGR1	7.36e-06	3	55	2	14755516
Pubmed	NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators.	CLOCK NPAS2	7.36e-06	3	55	2	26895328
Pubmed	Bestrophin Cl- channels are highly permeable to HCO3-.	BEST2 BEST4	7.36e-06	3	55	2	18400985
Pubmed	Circadian variation of blood pressure and the vascular response to asynchronous stress.	CLOCK NPAS2	7.36e-06	3	55	2	17360665
Pubmed	Peripheral circadian oscillators require CLOCK.	CLOCK NPAS2	7.36e-06	3	55	2	17637349
Pubmed	Association of Per1 and Npas2 with autistic disorder: support for the clock genes/social timing hypothesis.	CLOCK NPAS2	7.36e-06	3	55	2	17264841
Pubmed	Association of CLOCK, ARNTL, and NPAS2 gene polymorphisms and seasonal variations in mood and behavior.	CLOCK NPAS2	7.36e-06	3	55	2	26134245
Pubmed	Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors.	CLOCK NPAS2	7.36e-06	3	55	2	11441146
Pubmed	Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration.	CLOCK NPAS2	7.36e-06	3	55	2	24270424
Pubmed	Cellugyrin and synaptogyrin facilitate targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment in PC12 cells.	SYNGR2 SYNGR1	7.36e-06	3	55	2	12928441
Pubmed	Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.	SCN2A SCN8A	7.36e-06	3	55	2	17928448
Pubmed	Breast cancer risk, nightwork, and circadian clock gene polymorphisms.	CLOCK NPAS2	7.36e-06	3	55	2	24919398
Pubmed	CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock.	CLOCK NPAS2	7.36e-06	3	55	2	17417633
Pubmed	Experimental and computational evidence that Calpain-10 binds to the carboxy terminus of NaV1.2 and NaV1.6.	SCN2A SCN8A	7.36e-06	3	55	2	38514708
Pubmed	Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.	SCN2A SCN8A	7.36e-06	3	55	2	32845893
Pubmed	Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea.	SCN2A SCN8A	7.36e-06	3	55	2	16033895
Pubmed	Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons.	SCN2A SCN8A	7.36e-06	3	55	2	29991598
Pubmed	ZDHHC19 localizes to the cell membrane of spermatids and is involved in spermatogenesis†.	ZDHHC11B ZDHHC11	7.36e-06	3	55	2	34897408
Pubmed	Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.	SCN2A SCN8A	7.36e-06	3	55	2	28518218
Pubmed	Three novel human VMD2-like genes are members of the evolutionary highly conserved RFP-TM family.	BEST2 BEST4	1.47e-05	4	55	2	12032738
Pubmed	Bestrophin expression and function in the human pancreatic duct cell line, CFPAC-1.	BEST2 BEST4	1.47e-05	4	55	2	19237432
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN2A SCN8A	1.47e-05	4	55	2	17537961
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN2A SCN8A	1.47e-05	4	55	2	35031483
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN2A SCN8A	1.47e-05	4	55	2	29578003
Pubmed	Genetic components of the circadian clock regulate thrombogenesis in vivo.	CLOCK NPAS2	1.47e-05	4	55	2	18413500
Pubmed	FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1-induced transcription.	FTO CLOCK	1.47e-05	4	55	2	26188089
Pubmed	Structure-function analysis of the bestrophin family of anion channels.	BEST2 BEST4	1.47e-05	4	55	2	12907679
Pubmed	ARNTL (BMAL1) and NPAS2 gene variants contribute to fertility and seasonality.	CLOCK NPAS2	1.47e-05	4	55	2	20368993
Pubmed	Functionally Complete Excision of Conditional Alleles in the Mouse Suprachiasmatic Nucleus by Vgat-ires-Cre.	CLOCK NPAS2	1.47e-05	4	55	2	29671710
Pubmed	ZDHHC11 modulates innate immune response to DNA virus by mediating MITA-IRF3 association.	ZDHHC11B ZDHHC11	1.47e-05	4	55	2	29429998
Pubmed	Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.	SCN2A SCN8A	1.47e-05	4	55	2	21156207
Pubmed	Circadian modulation of gene expression, but not glutamate uptake, in mouse and rat cortical astrocytes.	CLOCK NPAS2	1.47e-05	4	55	2	19829696
Pubmed	Mutations in a novel gene, VMD2, encoding a protein of unknown properties cause juvenile-onset vitelliform macular dystrophy (Best's disease).	BEST2 BEST4	1.47e-05	4	55	2	9700209
Pubmed	Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression.	SCN2A SCN8A	2.45e-05	5	55	2	24077057
Pubmed	Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators.	CLOCK NPAS2	2.45e-05	5	55	2	18316400
Pubmed	Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts.	SYNGR3 SYNGR1	2.45e-05	5	55	2	31090538
Pubmed	CLOCK gene variants associate with sleep duration in two independent populations.	CLOCK NPAS2	2.45e-05	5	55	2	20149345
Pubmed	Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock.	CLOCK NPAS2	2.45e-05	5	55	2	11439184
Pubmed	Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.	SCN2A SCN8A	2.45e-05	5	55	2	17724025
Pubmed	ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization.	ZDHHC11B ZDHHC11	3.67e-05	6	55	2	34490261
Pubmed	Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?	SCN2A SCN8A	3.67e-05	6	55	2	17513486
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN2A SCN8A	3.67e-05	6	55	2	23652591
Pubmed	Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.	GRAMD1B GRAMD1A	3.67e-05	6	55	2	30220461
Pubmed	The trophoblast clock controls transport across placenta in mice.	CLOCK NPAS2	5.13e-05	7	55	2	33913482
Pubmed	In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.	ZDHHC11B ZDHHC11	5.13e-05	7	55	2	23687301
Pubmed	The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors.	CLOCK NPAS2	5.13e-05	7	55	2	9576906
Pubmed	Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.	SCN2A SCN8A	5.13e-05	7	55	2	25818041
Pubmed	Transcriptional architecture and chromatin landscape of the core circadian clock in mammals.	CLOCK NPAS2	5.13e-05	7	55	2	22936566
Pubmed	The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis.	CHD4 ELSPBP1	6.83e-05	8	55	2	20714342
Pubmed	The methamphetamine-sensitive circadian oscillator does not employ canonical clock genes.	CLOCK NPAS2	6.83e-05	8	55	2	19204282
Pubmed	Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice.	C12orf71 ADAM18 SYNGR4	8.29e-05	53	55	3	27357688
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN2A SCN8A	8.78e-05	9	55	2	15746173
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN2A SCN8A	8.78e-05	9	55	2	16382098
Pubmed	Inherited ACTH insensitivity illuminates the mechanisms of ACTH action.	RTP3 RTP4	1.10e-04	10	55	2	16271481
Pubmed	Members of RTP and REEP gene families influence functional bitter taste receptor expression.	RTP3 RTP4	1.10e-04	10	55	2	16720576
Pubmed	RTP family members induce functional expression of mammalian odorant receptors.	RTP3 RTP4	1.10e-04	10	55	2	15550249
Pubmed	Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study.	CLOCK NPAS2	1.10e-04	10	55	2	19934327
Pubmed	Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder.	CLOCK NPAS2	1.10e-04	10	55	2	16528748
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	GRAMD1B CD300LD ADAM18 SYNGR2 SYPL2 PAPLN ZDHHC11 ZDHHC4	1.51e-04	985	55	8	12975309
Pubmed	Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.	CLOCK NPAS2	1.60e-04	12	55	2	14645221
Pubmed	Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.	SCN2A SCN8A	1.60e-04	12	55	2	30175250
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN2A SCN8A	1.89e-04	13	55	2	15123669
Pubmed	WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.	SCN2A SCN8A	1.89e-04	13	55	2	16723544
Pubmed	Chronic Alcohol Exposure and the Circadian Clock Mutation Exert Tissue-Specific Effects on Gene Expression in Mouse Hippocampus, Liver, and Proximal Colon.	NOX1 CLOCK NPAS2	2.24e-04	74	55	3	26332085
Pubmed	PER2 variantion is associated with depression vulnerability.	CLOCK NPAS2	2.90e-04	16	55	2	19693801
Pubmed	Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.	SCN2A SCN8A	3.70e-04	18	55	2	37321992
Pubmed	CLOCK is suggested to associate with comorbid alcohol use and depressive disorders.	CLOCK NPAS2	3.70e-04	18	55	2	20180986
Pubmed	NPAS2 and PER2 are linked to risk factors of the metabolic syndrome.	CLOCK NPAS2	3.70e-04	18	55	2	19470168
Pubmed	Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance.	CLOCK NPAS2	3.70e-04	18	55	2	20174623
Pubmed	A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.	CHD4 ZMYM3	3.70e-04	18	55	2	12493763
Pubmed	Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.	CLOCK NPAS2	4.13e-04	19	55	2	20072116
Pubmed	Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption.	CLOCK NPAS2	4.13e-04	19	55	2	20554694
Pubmed	Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins.	ZDHHC11 ZDHHC4	4.58e-04	20	55	2	16647879
Pubmed	Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia.	CLOCK NPAS2	5.06e-04	21	55	2	19839995
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	ADRA1A GRAMD1A SYNGR2 ZDHHC11 ZDHHC4 RTP4	7.98e-04	697	55	6	28298427
Pubmed	Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A.	ADRA1A SCN8A	9.04e-04	28	55	2	19352218
Cytoband	5p15.33	ZDHHC11B ZDHHC11	6.83e-04	32	55	2	5p15.33
Cytoband	8p22	CCAR2 FGL1	1.07e-03	40	55	2	8p22
GeneFamily	Zinc fingers DHHC-type\|Ankyrin repeat domain containing	ZDHHC11B ZDHHC11 ZDHHC4	1.55e-05	24	37	3	76
GeneFamily	Bestrophins	BEST2 BEST4	2.44e-05	4	37	2	866
GeneFamily	Zinc fingers 3CxxC-type\|Receptor transporter proteins	RTP3 RTP4	4.06e-05	5	37	2	719
GeneFamily	Zinc fingers 3CxxC-type\|Receptor transporter proteins	RTP3 RTP4	1.13e-04	8	37	2	137
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN2A SCN8A	1.45e-04	9	37	2	1203
GeneFamily	WD repeat domain containing\|GRAM domain containing\|BEACH domain containing	GRAMD1B GRAMD1A	3.13e-04	13	37	2	1146
GeneFamily	Fibrinogen C domain containing	FCN2 FGL1	1.19e-03	25	37	2	554
Disease	Bipolar Disorder	ADRA1A INPP1 SCN2A SYNGR1 SCN8A GRM7 CLOCK NPAS2	1.11e-06	477	49	8	C0005586
Disease	Benign familial infantile epilepsy	SCN2A SCN8A	8.10e-06	3	49	2	cv:C5575231
Disease	Familial benign neonatal epilepsy	SCN2A SCN8A	4.04e-05	6	49	2	C0220669
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN2A SCN8A	1.21e-04	10	49	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN2A SCN8A	1.21e-04	10	49	2	DOID:0080422 (implicated_via_orthology)
Disease	cocaine use	ADRA1A CLOCK	1.47e-04	11	49	2	C3496069
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN2A SCN8A	1.76e-04	12	49	2	DOID:0060170 (implicated_via_orthology)
Disease	Seasonal Affective Disorder	CLOCK NPAS2	3.19e-04	16	49	2	C0085159
Disease	Neurodevelopmental Disorders	SCN2A SCN8A WDFY3	5.03e-04	93	49	3	C1535926
Disease	traumatic brain injury (biomarker_via_orthology)	NOX1 FTO	7.28e-04	24	49	2	DOID:0081292 (biomarker_via_orthology)
Disease	Mental Depression	FTO GRM7 CLOCK NPAS2	8.38e-04	254	49	4	C0011570
Disease	Depressive disorder	FTO GRM7 CLOCK NPAS2	1.35e-03	289	49	4	C0011581
Disease	multiple myeloma (is_marker_for)	NOX1 FTO	1.64e-03	36	49	2	DOID:9538 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SDFNKYWVPCVWFTN	BEST4	176	Q8NFU0
LSGCTKWWRFAEFQY	CCAR2	396	Q8N163
YWVPCVWFSNLAAQA	BEST2	181	Q8NFU1
FFGNSWAETYRNRFW	AKR7A2	251	O43488
ETYLKWRCQGADWNY	CD300LD	46	Q6UXZ3
WRKNNGFWSFGFFII	ABCA10	1041	Q8WWZ4
YNTHWNNWFILSFCI	ADAM18	681	Q9Y3Q7
YWAFGRVFCNIWAAV	ADRA1A	91	P35348
CDSRYFWGWLNAVFN	DMAC2L	36	Q99766
FWGWLNAVFNKVDYD	DMAC2L	41	Q99766
LSENWICFYSNIFRW	GRAMD1A	126	Q96CP6
LSENWICFYSNIFRW	GRAMD1B	131	Q3KR37
WEFYQTLCQGEWKAS	AFMID	256	Q63HM1
SCCYRFLTKGQQWIW	NPAS2	311	Q99743
YWICRETGAFSWFNN	NOX1	436	Q9Y5S8
NTLRWKGQCYWGLSY	INPP1	211	P49441
QFWFQGNRYRKCTDW	FTO	381	Q9C0B1
GNKLTYQNFRLNWAW	FREM2	1756	Q5SZK8
WTWKRDERYFFQGNQ	MMP21	401	Q8N119
FKNLQEIWRCYWQYL	NEMP1	236	O14524
TVNCFYWFDAQQNTW	KBTBD2	346	Q8IY47
NWNKFSGFWYILATA	LCN10	36	Q6JVE6
QEAEAWLNYPCFKNW	OAS1	321	P00973
AYATFCRPKENWWQY	PDP1	51	Q9P0J1
SNGWQKLWVVFTNFC	FARP1	946	Q9Y4F1
FFNIKFVNSAWGWTC	FITM1	86	A5D6W6
FQGAWWYKNCHVSNL	FCN2	261	Q15485
WWFNRCHSANLNGVY	FGL1	256	Q08830
RWQTAVFNRAFYSWG	MBTPS2	51	O43462
PWCATRAVYNGQWKY	ELSPBP1	51	Q96BH3
NVWFAEYWEENFNCK	GRM7	361	Q14831
RQFFVKWQGMSYWHC	CHD4	541	Q14839
RRFFNWFYWSINLGA	SLC15A3	196	Q8IY34
WWALSTCGYFQVVNY	SLC19A2	301	O60779
FYANDTGAQQFEKWW	SLC38A9	271	Q8NBW4
GWMQYQQWTFARFQC	RTP3	41	Q9BQQ7
GWKQYQQRAFGWFRC	RTP4	41	Q96DX8
INFFLWAGNCWFVFK	SYPL2	221	Q5VXT5
SNENYTFCWRVFCAW	TMC3	261	Q7Z5M5
KNNVFFSWSYFSGWL	CLDND2	121	Q8NHS1
SCYYRFLTKGQQWIW	CLOCK	336	O15516
QAQCCLNFGWAFSWL	C12orf71	206	A8MTZ7
WKQQGQQYSHVSCWF	ZNF343	151	Q6P1L6
WNKTFAWGYADLSCR	WDFY3	3046	Q8IZQ1
WAARWYFVASVGQCN	PAPLN	766	O95428
WVNNCIGAWNIRYFL	ZDHHC4	181	Q9NPG8
FQVYFTNAWCWLDFL	SCN2A	1266	Q99250
WTAYGFVKFFTNAWC	SCN8A	1251	Q9UQD0
AFLWFVGFCYLANQW	SYNGR1	116	O43759
FLWFVGFCFLTNQWA	nan	116	A8MWL6
TFLWFVGFCFLTNQW	SYNGR2	116	O43760
SFLWFVGFCFLTNQW	SYNGR3	116	O43761
VWFMGFCFLANQWQH	SYNGR4	116	O95473
KWINNCVGSRNYWFF	ZDHHC11	156	Q9H8X9
KWINNCVGSRNYWFF	ZDHHC11B	156	P0C7U3
GLNYSYGVNAWKCWV	ZMYM3	1061	Q14202
ISKNCREWWYFALNA	VPS13D	311	Q5THJ4