Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Homeobox	HOXA3 POU4F1 IRX5 ONECUT3	2.89e-04	234	26	4	PF00046
Domain	HOMEOBOX_1	HOXA3 POU4F1 IRX5 ONECUT3	2.99e-04	236	26	4	PS00027
Domain	HOX	HOXA3 POU4F1 IRX5 ONECUT3	3.03e-04	237	26	4	SM00389
Domain	Homeobox_dom	HOXA3 POU4F1 IRX5 ONECUT3	3.13e-04	239	26	4	IPR001356
Domain	HOMEOBOX_2	HOXA3 POU4F1 IRX5 ONECUT3	3.13e-04	239	26	4	PS50071
Domain	-	HOXA3 POU4F1 IRX5 ONECUT3	5.93e-04	283	26	4	1.10.10.60
Domain	-	POU4F1 ONECUT3	6.40e-04	27	26	2	1.10.260.40
Domain	Lambda_DNA-bd_dom	POU4F1 ONECUT3	7.39e-04	29	26	2	IPR010982
Domain	Homeodomain-like	HOXA3 POU4F1 IRX5 ONECUT3	1.08e-03	332	26	4	IPR009057
Domain	Homeobox_CS	HOXA3 POU4F1 IRX5	2.13e-03	186	26	3	IPR017970
Domain	SAM_1	SHANK1 PPFIA1	4.01e-03	68	26	2	PF00536
Domain	SAM	SHANK1 PPFIA1	6.63e-03	88	26	2	SM00454
Domain	SAM_DOMAIN	SHANK1 PPFIA1	7.68e-03	95	26	2	PS50105
Domain	SAM	SHANK1 PPFIA1	8.00e-03	97	26	2	IPR001660
Domain	-	SHANK1 PPFIA1	9.49e-03	106	26	2	1.10.150.50
Domain	SAM/pointed	SHANK1 PPFIA1	1.15e-02	117	26	2	IPR013761
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	SHANK1 DLGAP3 PPFIA1	9.42e-05	67	19	3	MM15327
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	SHANK1 DLGAP3 PPFIA1	2.05e-04	87	19	3	M27617
Pathway	REACTOME_NEUREXINS_AND_NEUROLIGINS	SHANK1 DLGAP3	8.33e-04	32	19	2	MM15326
Pathway	REACTOME_NEURONAL_SYSTEM	SHANK1 DLGAP3 PANX2 PPFIA1	9.15e-04	335	19	4	MM14503
Pubmed	Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression.	POU4F1 BCL11B ONECUT3	9.52e-06	53	27	3	27210758
Pubmed	Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities.	SHANK1 DLGAP3	1.62e-05	8	27	2	19640847
Pubmed	Dual recombinase fate mapping reveals a transient cholinergic phenotype in multiple populations of developing glutamatergic neurons.	POU4F1 BCL11B	2.08e-05	9	27	2	31396962
Pubmed	Nav2 is necessary for cranial nerve development and blood pressure regulation.	HOXA3 POU4F1	2.08e-05	9	27	2	20184720
Pubmed	Dual effect of CTCF loss on neuroprogenitor differentiation and survival.	BCL11B BBC3	3.81e-05	12	27	2	24553927
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	SHANK1 PRR12 SF3B4 BCL11B TRIO	4.23e-05	513	27	5	25798074
Pubmed	Zeb1 is important for proper cleavage plane orientation of dividing progenitors and neuronal migration in the mouse neocortex.	POU4F1 BCL11B	4.50e-05	13	27	2	30858607
Pubmed	The Purinergic Receptor P2rx3 is Required for Spiral Ganglion Neuron Branch Refinement during Development.	SHANK1 POU4F1	4.50e-05	13	27	2	32675174
Pubmed	Onecut factors control development of the Locus Coeruleus and of the mesencephalic trigeminal nucleus.	POU4F1 ONECUT3	5.25e-05	14	27	2	22534286
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	TBX19 POU4F1 BCL11B IRX5 ONECUT3	5.58e-05	544	27	5	28473536
Pubmed	A census of human transcription factors: function, expression and evolution.	HOXA3 TBX19 POU4F1 BCL11B IRX5 ONECUT3	5.77e-05	908	27	6	19274049
Pubmed	Satb2 Is Required for the Development of a Spinal Exteroceptive Microcircuit that Modulates Limb Position.	POU4F1 BCL11B	6.06e-05	15	27	2	27478017
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	SHANK1 DLGAP3 TRIO PPFIA1	6.32e-05	281	27	4	28706196
Pubmed	The Onecut Transcription Factors Regulate Differentiation and Distribution of Dorsal Interneurons during Spinal Cord Development.	POU4F1 ONECUT3	6.92e-05	16	27	2	28603487
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SHANK1 DLGAP3 BCL11B TRIO GOLGA8A PPFIA1	7.98e-05	963	27	6	28671696
Pubmed	EphrinB3/EphA4-mediated guidance of ascending and descending spinal tracts.	POU4F1 BCL11B	8.81e-05	18	27	2	24360544
Pubmed	Onecut1 and Onecut2 transcription factors operate downstream of Pax6 to regulate horizontal cell development.	POU4F1 ONECUT3	8.81e-05	18	27	2	25794677
Pubmed	m6A regulation of cortical and retinal neurogenesis is mediated by the redundant m6A readers YTHDFs.	POU4F1 BCL11B	9.84e-05	19	27	2	36039295
Pubmed	Loss of the neurodevelopmental gene Zswim6 alters striatal morphology and motor regulation.	BCL11B ZSWIM5	9.84e-05	19	27	2	28433741
Pubmed	Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis.	BCL11B BBC3	9.84e-05	19	27	2	37612280
Pubmed	Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion.	BCL11B BBC3	1.33e-04	22	27	2	31197172
Pubmed	Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment.	BCL11B GOLGA8A	1.45e-04	23	27	2	21111240
Pubmed	Ectopic clustering of Cajal-Retzius and subplate cells is an initial pathological feature in Pomgnt2-knockout mice, a model of dystroglycanopathy.	BCL11B GOLGA8A	1.59e-04	24	27	2	26060116
Pubmed	Ezh2 is required for neural crest-derived cartilage and bone formation.	HOXA3 POU4F1	1.59e-04	24	27	2	24496623
Pubmed	Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans.	DLGAP3 BCL11B	1.72e-04	25	27	2	28288114
Pubmed	Genome-wide association analyses identify variants in developmental genes associated with hypospadias.	HOXA3 IRX5	1.72e-04	25	27	2	25108383
Pubmed	CDK5RAP2 expression during murine and human brain development correlates with pathology in primary autosomal recessive microcephaly.	BCL11B GOLGA8A	1.86e-04	26	27	2	22806269
Pubmed	Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling.	BCL11B BBC3	2.01e-04	27	27	2	33462115
Pubmed	Maf1 controls retinal neuron number by both RNA Pol III- and Pol II-dependent mechanisms.	POU4F1 IRX5	2.66e-04	31	27	2	38089586
Pubmed	Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals.	HOXA3 IRX5	2.84e-04	32	27	2	38110169
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	PRR12 RPRD2 SF3B4	3.64e-04	180	27	3	35198878
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	PRR12 PPP1R10 RPRD2	3.88e-04	184	27	3	32908313
Pubmed	A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain.	POU4F1 ONECUT3	4.01e-04	38	27	2	39106860
Pubmed	Identification of UHRF1/2 as new N-methylpurine DNA glycosylase-interacting proteins.	PPP1R10 RPRD2	4.01e-04	38	27	2	23537643
Pubmed	Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors.	BCL11B GOLGA8A	4.90e-04	42	27	2	24210661
Pubmed	Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex.	BCL11B BBC3	5.88e-04	46	27	2	35864088
Pubmed	Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death.	BCL11B BBC3	7.51e-04	52	27	2	35361962
GeneFamily	Sterile alpha motif domain containing	SHANK1 PPFIA1	3.41e-03	88	18	2	760
Disease	Acute Myeloid Leukemia, M1	POU4F1 TRIO MN1	1.80e-04	125	26	3	C0026998
Disease	Acute Myeloid Leukemia (AML-M2)	POU4F1 TRIO MN1	1.80e-04	125	26	3	C1879321
Disease	Mitral valve prolapse	MN1 TMEM40	4.62e-04	36	26	2	HP_0001634
Disease	Leukemia, Myelocytic, Acute	POU4F1 TRIO MN1	4.66e-04	173	26	3	C0023467
Disease	Intellectual Disability	PRR12 BCL11B TRIO MN1	5.96e-04	447	26	4	C3714756
Disease	Congenital Heart Defects	HOXA3 IRX5	6.90e-04	44	26	2	C0018798
Disease	Retinitis Pigmentosa	C1QTNF5 IRX5	3.78e-03	104	26	2	C0035334
Disease	Global developmental delay	PRR12 MN1	6.11e-03	133	26	2	C0557874
Disease	inflammatory bowel disease	IFFO2 DLGAP3 BCL11B	7.02e-03	449	26	3	EFO_0003767
Disease	Craniofacial Abnormalities	HOXA3 IRX5	8.31e-03	156	26	2	C0376634
Disease	dyslexia	BCL11B PANX2	8.93e-03	162	26	2	EFO_0005424
Disease	response to xenobiotic stimulus	IFFO2 PLPP6	1.12e-02	182	26	2	GO_0009410

Protein segments in the cluster

Peptide	Gene	Start	Entry
PSPGHGGKHGGGDQG	CDRT15L2	176	A8MXV6
PGGSGGRSHPGGPGS	BBC3	146	Q96PG8
GSFGHLHGHPGPGPG	IRX5	416	P78411
GGPGGGLLGGSAHPH	POU4F1	176	Q01851
PSHGGVPPGGPSHSS	H1-8	31	Q8IZA3
AGPLGSGHHHGPGPG	HOXA3	401	O43365
PGGGGGHGSGSPSQP	PPFIA1	16	Q13136
ASGGSTPHLGGPGPG	BCL11B	771	Q9C0K0
HPGLPGTPGHHGSQG	C1QTNF5	31	Q9BXJ0
SGGDSYPGPGSGGPH	DLGAP3	206	O95886
GGLPPGGGSHPQHYG	IFFO2	141	Q5TF58
PPHGGGGGGGSNSSS	RPRD2	1381	Q5VT52
GPHGPGTSGGPRSHG	DELE1	51	Q14154
AHHYKGGGGDPGPGP	PANX2	481	Q96RD6
AAAGAHGPHGGGGGP	ONECUT3	291	O60422
DSYGGGGGPGHPGTP	MN1	1116	Q10571
SPGGGHHQAGPGQGG	GOLGA8A	496	A7E2F4
PGSGPGHGSGSHPGP	SPAG8	181	Q99932
GHGSGSHPGPASGPG	SPAG8	186	Q99932
GHSPALSGHGGGWGP	PRR12	536	Q9ULL5
APSPSHHGSAGGGGG	SHANK1	1061	Q9Y566
HHGSAGGGGGSSQGP	SHANK1	1066	Q9Y566
HHPRGSPGAAGGGAG	ZSWIM5	31	Q9P217
AGYPHGNGSPGPGHG	TMEM40	91	Q8WWA1
SSSPGSPAHGGGGGG	PLPP6	21	Q8IY26
GWGGPGAGGHHSPSS	TBX19	431	O60806
GPGGGMGNSSGHRPH	PPP1R10	756	Q96QC0
GPGGSMGGGGGHRPH	PPP1R10	786	Q96QC0
PHEGPGGSMGGSGGH	PPP1R10	831	Q96QC0
GSGGHRPHEGPGHGG	PPP1R10	841	Q96QC0
AGHGPPSAGTPGAGH	SF3B4	271	Q15427
PSAGTPGAGHPGHGH	SF3B4	276	Q15427
GGAPSGGSGHSGGPS	TRIO	2311	O75962