Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.27e-06	24	79	4	GO:0008392
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP2A7 CYP2B6 CYP2F1 CYP2S1	3.72e-06	27	79	4	GO:0008391
GeneOntologyMolecularFunction	aromatase activity	CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.08e-05	35	79	4	GO:0070330
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2A7 CYP2B6 CYP2F1 CYP2S1	4.20e-05	49	79	4	GO:0016712
GeneOntologyMolecularFunction	monooxygenase activity	CYP2A7 CYP2B6 MIOX CYP2F1 CYP2S1	9.32e-05	115	79	5	GO:0004497
GeneOntologyMolecularFunction	clathrin light chain binding	CLTCL1 CLTC	3.20e-04	7	79	2	GO:0032051
GeneOntologyMolecularFunction	iron ion binding	CYP2A7 CYP2B6 MIOX CYP2F1 CYP2S1	5.13e-04	166	79	5	GO:0005506
GeneOntologyBiologicalProcess	epoxygenase P450 pathway	CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.25e-06	22	77	4	GO:0019373
Domain	Clathrin_H-chain_propeller_rpt	CLTCL1 CLTC	1.63e-05	2	76	2	IPR022365
Domain	Clathrin-link	CLTCL1 CLTC	1.63e-05	2	76	2	PF09268
Domain	-	CLTCL1 CLTC	1.63e-05	2	76	2	2.130.10.110
Domain	Clathrin_H-chain_link/propller	CLTCL1 CLTC	1.63e-05	2	76	2	IPR016025
Domain	Clathrin_propel	CLTCL1 CLTC	1.63e-05	2	76	2	PF01394
Domain	Clathrin_heavy_chain	CLTCL1 CLTC	1.63e-05	2	76	2	IPR016341
Domain	Clathrin_H-chain_linker_core	CLTCL1 CLTC	1.63e-05	2	76	2	IPR015348
Domain	Clathrin_H-chain_propeller_N	CLTCL1 CLTC	1.63e-05	2	76	2	IPR001473
Domain	Cyt_P450_E_grp-I	CYP2A7 CYP2B6 CYP2F1 CYP2S1	3.32e-05	45	76	4	IPR002401
Domain	Cyt_P450_E_grp-I_CYP2B-like	CYP2B6 CYP2F1	4.89e-05	3	76	2	IPR008068
Domain	Clathrin_H-chain_linker	CLTCL1 CLTC	4.89e-05	3	76	2	IPR012331
Domain	CLH	CLTCL1 CLTC	4.89e-05	3	76	2	SM00299
Domain	Cyt_P450_CS	CYP2A7 CYP2B6 CYP2F1 CYP2S1	6.37e-05	53	76	4	IPR017972
Domain	CYTOCHROME_P450	CYP2A7 CYP2B6 CYP2F1 CYP2S1	8.49e-05	57	76	4	PS00086
Domain	-	CYP2A7 CYP2B6 CYP2F1 CYP2S1	9.09e-05	58	76	4	1.10.630.10
Domain	p450	CYP2A7 CYP2B6 CYP2F1 CYP2S1	9.09e-05	58	76	4	PF00067
Domain	Cyt_P450_E_grp-I_CYP2A-like	CYP2A7 CYP2S1	9.75e-05	4	76	2	IPR008067
Domain	Cyt_P450	CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.04e-04	60	76	4	IPR001128
Domain	Clathrin	CLTCL1 CLTC	3.39e-04	7	76	2	PF00637
Domain	CHCR	CLTCL1 CLTC	3.39e-04	7	76	2	PS50236
Domain	Clathrin_H-chain/VPS_repeat	CLTCL1 CLTC	4.50e-04	8	76	2	IPR000547
Domain	Calx_beta	FRAS1 FREM1	5.77e-04	9	76	2	IPR003644
Domain	LisH	TBL1Y TBL1XR1	5.77e-04	9	76	2	PF08513
Domain	Calx-beta	FRAS1 FREM1	5.77e-04	9	76	2	PF03160
Domain	Furin_repeat	FRAS1 INSR	2.40e-03	18	76	2	IPR006212
Domain	FU	FRAS1 INSR	2.40e-03	18	76	2	SM00261
Domain	LisH	TBL1Y TBL1XR1	5.77e-03	28	76	2	SM00667
Domain	LisH	TBL1Y TBL1XR1	5.77e-03	28	76	2	IPR006594
Domain	LISH	TBL1Y TBL1XR1	5.77e-03	28	76	2	PS50896
Pathway	REACTOME_CYP2E1_REACTIONS	CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.02e-07	11	61	4	M27130
Pathway	REACTOME_CYP2E1_REACTIONS	CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.53e-07	12	61	4	MM14847
Pathway	REACTOME_XENOBIOTICS	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.64e-06	23	61	4	M5372
Pathway	REACTOME_XENOBIOTICS	CYP2A7 CYP2B6 CYP2F1 CYP2S1	3.75e-06	25	61	4	MM14846
Pathway	REACTOME_GAP_JUNCTION_DEGRADATION	GJA1 CLTCL1 CLTC	1.65e-05	12	61	3	M15243
Pathway	REACTOME_FATTY_ACIDS	CYP2A7 CYP2B6 CYP2F1	3.38e-05	15	61	3	M27126
Pathway	REACTOME_FATTY_ACIDS	CYP2A7 CYP2B6 CYP2F1	6.01e-05	18	61	3	MM14841
Pathway	WP_OXIDATION_BY_CYTOCHROME_P450	CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.47e-04	62	61	4	M39653
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.66e-04	64	61	4	M5650
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.87e-04	66	61	4	MM14839
Pubmed	Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19.	CYP2A7 CYP2B6 CYP2F1	2.24e-07	6	79	3	8587134
Pubmed	Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster.	CYP2A7 CYP2B6 CYP2S1	3.92e-07	7	79	3	14630516
Pubmed	Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.	CYP2A7 CYP2B6 CYP2F1 CYP2S1	3.12e-06	44	79	4	12745259
Pubmed	Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.	CLTCL1 CLTC	5.09e-06	2	79	2	8733129
Pubmed	Overlapping and divergent localization of Frem1 and Fras1 and its functional implications during mouse embryonic development.	FRAS1 FREM1	5.09e-06	2	79	2	17240369
Pubmed	CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function.	CLTCL1 CLTC	5.09e-06	2	79	2	29097553
Pubmed	The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.	CLTCL1 CLTC	5.09e-06	2	79	2	20065094
Pubmed	Phosphoinositide-dependent Kinase-1 (PDPK1) regulates serum/glucocorticoid-regulated Kinase 3 (SGK3) for prostate cancer cell survival.	PDPK1 SGK3	5.09e-06	2	79	2	32926495
Pubmed	Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner.	PDPK1 SGK3	5.09e-06	2	79	2	14604990
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	MRPL23 GJA1 FRAS1 FAM193A LLGL1 POLE2 NUCB2 CLTC PANK4 DDX42 SRP54 TACC1 DZIP1 ERBIN	5.90e-06	1487	79	14	33957083
Pubmed	BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.	DOCK1 MRPL23 CLTCL1 ALMS1 CLTC ERBIN	1.32e-05	226	79	6	25900982
Pubmed	Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.	CLTCL1 CLTC	1.53e-05	3	79	2	19509056
Pubmed	SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular carcinoma.	SALL3 DNMT3A	1.53e-05	3	79	2	19139273
Pubmed	Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.	CLTCL1 CLTC	1.53e-05	3	79	2	22891263
Pubmed	Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling.	PDPK1 INSR	1.53e-05	3	79	2	16314505
Pubmed	Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): insights from a novel Cyp2abfgs-null mouse.	CYP2F1 CYP2S1	1.53e-05	3	79	2	25173884
Pubmed	Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration.	CLTCL1 CLTC	1.53e-05	3	79	2	15133132
Pubmed	Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.02e-05	70	79	4	15128046
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DOCK1 PKNOX2 CDH26 INSR NUCB2 PANK4 SRP54 ZNF84 DENND5A STEAP2 TBL1XR1 ERBIN CREB3L2	2.92e-05	1489	79	13	28611215
Pubmed	Generation and characterization of a CYP2A13/2B6/2F1-transgenic mouse model.	CYP2B6 CYP2F1	3.05e-05	4	79	2	22397853
Pubmed	The role of FREM2 and FRAS1 in the development of congenital diaphragmatic hernia.	FRAS1 FREM1	3.05e-05	4	79	2	29618029
Pubmed	Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice.	CYP2A7 CYP2B6	3.05e-05	4	79	2	1970547
Pubmed	Deficiency of FRAS1-related extracellular matrix 1 (FREM1) causes congenital diaphragmatic hernia in humans and mice.	FRAS1 FREM1	3.05e-05	4	79	2	23221805
Pubmed	Polymorphisms in methyl-group metabolism genes and risk of sporadic colorectal cancer with relation to the CpG island methylator phenotype.	TYMS DNMT3A	3.05e-05	4	79	2	20381446
Pubmed	Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis.	FRAS1 FREM1	3.05e-05	4	79	2	36495293
Pubmed	Differential localization profile of Fras1/Frem proteins in epithelial basement membranes of newborn and adult mice.	FRAS1 FREM1	3.05e-05	4	79	2	18563433
Pubmed	[Polymorphic markers of the CYP1B1 (4326C > G), CYP2F1 (c.14_15insC), CYP2J2 (-76G > T), and CYP2S1 (13106C > T and 13255A > G) genes and genetic predisposition to chronic respiratory diseases induced by smoking and occupational factors].	CYP2F1 CYP2S1	3.05e-05	4	79	2	22232929
Pubmed	HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.	CLTCL1 CLTC	3.05e-05	4	79	2	11517213
Pubmed	Spatiotemporal distribution of Fras1/Frem proteins during mouse embryonic development.	FRAS1 FREM1	5.07e-05	5	79	2	17251066
Pubmed	Protective role of AgRP neuron's PDK1 against salt-induced hypertension.	PDPK1 NUCB2	5.07e-05	5	79	2	29705701
Pubmed	Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia.	TBL1Y TBL1XR1	5.07e-05	5	79	2	21459324
Pubmed	Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium.	TYMS DNMT3A	5.07e-05	5	79	2	20570913
Pubmed	Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase.	PDPK1 SGK3	5.07e-05	5	79	2	10548550
Pubmed	Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.	PDPK1 INSR	5.07e-05	5	79	2	16581004
Pubmed	Novel frem1-related mouse phenotypes and evidence of genetic interactions with gata4 and slit3.	FRAS1 FREM1	5.07e-05	5	79	2	23536828
Pubmed	PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic Targets.	PDPK1 SGK3	5.07e-05	5	79	2	25712345
Pubmed	Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.	CLTCL1 CLTC	5.07e-05	5	79	2	10436022
Pubmed	Basement membrane localization of Frem3 is independent of the Fras1/Frem1/Frem2 protein complex within the sublamina densa.	FRAS1 FREM1	5.07e-05	5	79	2	17596926
Pubmed	Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders.	TBL1Y TBL1XR1	7.60e-05	6	79	2	28348241
Pubmed	A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.	CYP2A7 CYP2B6	7.60e-05	6	79	2	7668294
Pubmed	Serological identification and expression analysis of gastric cancer-associated genes.	NUCB2 TACC1	7.60e-05	6	79	2	12087473
Pubmed	Craniofacial consequences of connective tissue disorders in mice.	FRAS1 FREM1	7.60e-05	6	79	2	6391574
Pubmed	Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract.	FRAS1 FREM1	7.60e-05	6	79	2	24700879
Pubmed	Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue distribution patterns distinct from those of Fras1, Frem2, and QBRICK/Frem1.	FRAS1 FREM1	7.60e-05	6	79	2	17462874
Pubmed	Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3).	PDPK1 SGK3	7.60e-05	6	79	2	20687898
Pubmed	A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism.	CLTCL1 CLTC	1.06e-04	7	79	2	19478182
Pubmed	Zbtb7c is a molecular 'off' and 'on' switch of Mmp gene transcription.	TBL1Y TBL1XR1	1.06e-04	7	79	2	27646874
Pubmed	The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor.	TBL1Y TBL1XR1	1.06e-04	7	79	2	15695367
Pubmed	ADP-ribosylation factor-like GTPase 15 enhances insulin-induced AKT phosphorylation in the IR/IRS1/AKT pathway by interacting with ASAP2 and regulating PDPK1 activity.	PDPK1 INSR	1.41e-04	8	79	2	28322786
Pubmed	Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor.	TBL1Y TBL1XR1	1.41e-04	8	79	2	23770565
Pubmed	A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.	TBL1Y TBL1XR1	1.41e-04	8	79	2	16127449
Pubmed	CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.	CLTCL1 CLTC	2.27e-04	10	79	2	25898166
Pubmed	Connexins modulate autophagosome biogenesis.	GJA1 CLTC	2.27e-04	10	79	2	24705551
Pubmed	The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis.	FRAS1 FREM1	2.27e-04	10	79	2	15345741
Pubmed	A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.	TBL1Y TBL1XR1	2.27e-04	10	79	2	14980219
Pubmed	Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion.	CLTCL1 CLTC	2.76e-04	11	79	2	29604273
Pubmed	Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis.	COMP CREB3L2	3.91e-04	13	79	2	19767744
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	HEXB LLGL1 UNC5C INSR DZIP1 ERBIN	4.01e-04	421	79	6	36976175
Pubmed	Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.	ARFGAP2 BAZ1A UCK2 GRM2 TBL1XR1	4.24e-04	276	79	5	28319085
Pubmed	MED12 regulates a transcriptional network of calcium-handling genes in the heart.	GJA1 MED12	4.55e-04	14	79	2	28724790
Pubmed	The IgCAM CLMP regulates expression of Connexin43 and Connexin45 in intestinal and ureteral smooth muscle contraction in mice.	GJA1 CLTC	4.55e-04	14	79	2	29361518
Pubmed	Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors.	GJA1 CPS1	4.55e-04	14	79	2	16103213
Pubmed	Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.	ARFGAP2 CLTC	4.55e-04	14	79	2	16903783
Pubmed	Sprouty1 haploinsufficiency prevents renal agenesis in a model of Fraser syndrome.	FRAS1 FREM1	5.25e-04	15	79	2	23064016
Pubmed	Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism.	CYP2A7 CYP2B6	5.25e-04	15	79	2	29968852
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	ARFGAP2 DBF4 PDPK1 EIF2B2 SRP54 TBL1XR1 ERBIN MED12 SYDE1	5.75e-04	1038	79	9	26673895
Pubmed	Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.	FRAS1 FREM1	5.99e-04	16	79	2	16880404
Pubmed	Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.	CYP2A7 CYP2B6	6.78e-04	17	79	2	27197076
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	TYMS LLGL1 BAZ1A TACC1 ERBIN MED12	7.29e-04	472	79	6	38943005
Pubmed	A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.	FRAS1 FREM1	7.61e-04	18	79	2	14730302
Pubmed	Quantitative study of the interactome of PKCζ involved in the EGF-induced tumor cell chemotaxis.	LLGL1 UNC5C CLTC DZIP1	8.36e-04	184	79	4	23402259
Pubmed	Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population.	CYP2B6 CYP2S1	8.50e-04	19	79	2	12721789
Pubmed	Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers.	CYP2B6 CYP2F1	8.50e-04	19	79	2	8432525
Pubmed	Identification of Protor as a novel Rictor-binding component of mTOR complex-2.	CLTC CPS1	9.43e-04	20	79	2	17461779
Pubmed	Molecular genetics of the human cytochrome P450 monooxygenase superfamily.	CYP2A7 CYP2B6	9.43e-04	20	79	2	9890157
Pubmed	CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis.	BAZ1A UNC5C	1.04e-03	21	79	2	22154806
Pubmed	Stromal netrin 1 coordinates renal arteriogenesis and mural cell differentiation.	GJA1 UNC5C	1.14e-03	22	79	2	37823339
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	TYMS MRPL23 SMG1 CYRIA LLGL1 NUCB2 TBL1XR1	1.25e-03	719	79	7	35337019
Pubmed	PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential.	LLGL1 UNC5C ERBIN	1.30e-03	94	79	3	32062451
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	FAM193A ALMS1 SRP54 ERBIN	1.34e-03	209	79	4	36779422
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	GJA1 FAM193A ALMS1 NUCB2 DDX42 TACC1 ERBIN	1.40e-03	733	79	7	34672954
Pubmed	ZNF750 Regulates Skin Barrier Function by Driving Cornified Envelope and Lipid Processing Pathways.	CYP2B6 CYP2S1	1.48e-03	25	79	2	37660780
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SMG1 PDE6A CLTCL1 BAZ1A UNC5C NUCB2 CLTC DDX42 ZNF84 ERBIN	1.56e-03	1442	79	10	35575683
Pubmed	Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.	CLTCL1 CLTC	1.60e-03	26	79	2	24067654
Pubmed	Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role during Repair Kinetics after Selective Club Cell Ablation.	CYP2F1 INSR	1.60e-03	26	79	2	27861515
Pubmed	Resveratrol improves health and survival of mice on a high-calorie diet.	CYP2A7 CYP2B6	1.60e-03	26	79	2	17086191
Pubmed	Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network.	GJA1 MED12	1.60e-03	26	79	2	34506481
Pubmed	The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium.	PDPK1 CLTC	1.60e-03	26	79	2	26809587
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	SMG1 CLTC	1.72e-03	27	79	2	23027611
Pubmed	NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure.	GLRB DZIP1	1.72e-03	27	79	2	23359859
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	ARFGAP2 UNC5C INSR CLTC TACC1 ERBIN SYDE1	1.95e-03	777	79	7	35844135
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	DOCK1 LLGL1 CLTC TACC1	1.96e-03	232	79	4	25515538
Pubmed	Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.	FRAS1 FREM1	1.99e-03	29	79	2	22613833
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	HEXB GJA1 ARFGAP2 EIF2B2 NUCB2 SRP54 TACC1 ERBIN	2.04e-03	1007	79	8	34597346
Pubmed	Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP.	CLTCL1 CLTC	2.13e-03	30	79	2	22963397
Cytoband	18p11.32	TYMS CLUL1	5.44e-04	20	79	2	18p11.32
Cytoband	14q13.2	BAZ1A SRP54	8.55e-04	25	79	2	14q13.2
GeneFamily	Cytochrome P450 family 2	CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.98e-06	35	47	4	1001
ToppCell	Adult-Epithelial-club_cell\|Adult / Lineage, Cell type, age group and donor	CYP2A7 FRAS1 CYP2B6 CDH26 CYP2F1 INSR L3MBTL4	4.81e-08	190	79	7	756bff697d30aec56c0ebfca94295f084a15bf37
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A7 CYP2B6 LLGL1 CYP2F1 NUCB2 TBL1XR1	6.75e-07	174	79	6	42f2ba54b4ea4c62482582b0ccdadffae0a5eb4a
ToppCell	Adult-Epithelial-club_cell-D122\|Adult / Lineage, Cell type, age group and donor	CYP2A7 FRAS1 CYP2B6 CDH26 CYP2F1 INSR	7.71e-07	178	79	6	35a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCell	390C-Fibroblasts-Fibroblast-G\|390C / Donor, Lineage, Cell class and subclass (all cells)	FRAS1 CLTCL1 COMP DZIP1 STEAP2 SYDE1	8.23e-07	180	79	6	137fc14859c89e1ecd98bee388bb58c04b835847
ToppCell	390C-Fibroblasts-Fibroblast-G-\|390C / Donor, Lineage, Cell class and subclass (all cells)	FRAS1 CLTCL1 COMP DZIP1 STEAP2 SYDE1	8.23e-07	180	79	6	cd6790de050151fedfa2c5ea6ad58b72665414b2
ToppCell	Epithelial-club_cell\|World / Lineage, Cell type, age group and donor	CYP2A7 FRAS1 CYP2B6 CDH26 CYP2F1 L3MBTL4	1.24e-06	193	79	6	2bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP26 FRAS1 NDST4 CPS1 L3MBTL4	6.03e-06	145	79	5	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	356C-Myeloid-Dendritic-pDC\|356C / Donor, Lineage, Cell class and subclass (all cells)	SMG1 PDE6A SCAMP5 UCK2 KIF17	8.61e-06	156	79	5	d9d87368e43b24952e70f31f38425e15b716ff5b
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CYP2A7 FRAS1 CYP2B6 CDH26 TBL1Y	8.88e-06	157	79	5	6ee2692f705bdd93ba523dffaf2f0cd921b47e28
ToppCell	BAL-Mild-cDC_5\|Mild / Compartment, Disease Groups and Clusters	PDE6A PGGHG SCAMP5 INSR NPHP4	1.00e-05	161	79	5	7a6e8ed0b5d999efce8945d8083ab01d71be9a92
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	USP26 FRAS1 NDST4 CPS1 L3MBTL4	1.03e-05	162	79	5	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	TCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma-Intrahepatic-2\|TCGA-Bile_Duct / Sample_Type by Project: Shred V9	COMP ALMS1 GLRB TACC1 DENND5A	1.23e-05	168	79	5	c70bf73bb800e4722cedc35bbc17ea3113d1012d
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2B6 CDH26 CYP2F1 INSR FUT6	1.27e-05	169	79	5	40b557549fe08c5dc9dba359af35993d68d1640a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CYP2B6 MIOX INSR FUT6 L3MBTL4	1.34e-05	171	79	5	f5014e3c387fe3118944af392abe10d6b9b0abab
ToppCell	droplet-Lung-18m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TYMS DBF4 ITGAD NPHP4 TMEM81	1.54e-05	176	79	5	b17317ac41d3215db55a38cbd3366c0947f7a2a3
ToppCell	356C-Fibroblasts-Fibroblast-E-\|356C / Donor, Lineage, Cell class and subclass (all cells)	PDE6A MEDAG DZIP1 CPS1 STEAP2	1.63e-05	178	79	5	a493a277d175e5e153410a745b26ebe2e0839ea0
ToppCell	356C-Fibroblasts-Fibroblast-E\|356C / Donor, Lineage, Cell class and subclass (all cells)	PDE6A MEDAG DZIP1 CPS1 STEAP2	1.63e-05	178	79	5	371218babddfd3d8a7bb82a46ce65327ee3fcf12
ToppCell	Adult-Epithelial-lung_goblet_cell\|Adult / Lineage, Cell type, age group and donor	CDH26 CYP2F1 INSR FUT6 STEAP2	1.67e-05	179	79	5	1fc1f252ca943a2f649d1e627f56acbf15f8e058
ToppCell	Control-Epithelial-Club\|Epithelial / Disease state, Lineage and Cell class	CYP2A7 CYP2B6 CYP2F1 INSR UCK2	1.96e-05	185	79	5	6814b3c94c7558443c038a227b5c8563d2cfeac4
ToppCell	Adult-Epithelial-club_cell-D231\|Adult / Lineage, Cell type, age group and donor	FRAS1 CDH26 CYP2F1 INSR L3MBTL4	2.07e-05	187	79	5	ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCell	COVID-19_Mild-Neu_4\|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients	TYMS CLTCL1 NUCB2 NPHP4 SGK3	2.07e-05	187	79	5	714851e757c71c559ee6413a3f61d6c117c79ad2
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2B6 CYP2F1 INSR NUCB2 FUT6	2.12e-05	188	79	5	5901b276f2379abf486b8285957277e95f08464e
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEXB SALL3 SCAMP5 CLTC TACC1	2.17e-05	189	79	5	6dd4ec5ce4beb856f0d2d1654e3c4676d1d63736
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEXB SALL3 SCAMP5 CLTC TACC1	2.17e-05	189	79	5	3ae479ec7e00c57127cbe51a398329b10ca9848c
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEXB SALL3 SCAMP5 CLTC TACC1	2.17e-05	189	79	5	875df61ee48baa5142ba4d2427bdec1c53e5a828
ToppCell	facs-Brain_Myeloid-Striatum-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEXB SALL3 SCAMP5 CLTC TACC1	2.17e-05	189	79	5	97ef5215d841ff366a3e3682cd9bd04100cbfde0
ToppCell	Children_(3_yrs)-Epithelial-club_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CYP2A7 FRAS1 CYP2B6 CDH26 CYP2F1	2.29e-05	191	79	5	23776c7302cead3881b39127398f3b3e0d27885e
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PKNOX2 FRAS1 UNC5C STEAP2 FREM1	2.29e-05	191	79	5	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	DOCK1 PKNOX2 UNC5C TACC1 CREB3L2	2.34e-05	192	79	5	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A7 CYP2B6 CYP2F1 NUCB2 FUT6	2.40e-05	193	79	5	605fc2a25ed6846fb283b2918cfed98df6039d6b
ToppCell	NS-moderate-d_16-33-Epithelial-Secretory\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CYP2B6 CYP2F1 INSR FUT6 STEAP2	2.59e-05	196	79	5	70384c1da9baed843f414cfd1403ddd586a2db07
ToppCell	Bronchial_Biopsy-Epithelial-Club\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	CYP2B6 CYP2F1 INSR NUCB2 FUT6	2.59e-05	196	79	5	057d150bdf0cad959fd03ec2d1560a96ba03fae9
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2B6 CYP2F1 INSR NUCB2 FUT6	2.65e-05	197	79	5	ff19e4c45715752a04541ad6a0cdf5454c9daaa2
ToppCell	Bronchial_Biopsy-Epithelial-Club\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	CYP2B6 CYP2F1 INSR NUCB2 FUT6	2.65e-05	197	79	5	3f5dfa892a1f631b96eeb6f4cfc284aee51d1ce6
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FRAS1 CYP2B6 CDH26 CYP2F1 INSR	2.72e-05	198	79	5	af399569c718f5fd971d73a7926768c9311002a3
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CDH26 CYP2F1 INSR UCK2 FUT6	2.72e-05	198	79	5	af07a970afaa435c6433bb5c1cbff4c67af350c7
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2B6 CYP2F1 INSR NUCB2 FUT6	2.72e-05	198	79	5	778fee7020c82d11ff3984a8e482a23e5d58165f
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2B6 CYP2F1 INSR NUCB2 FUT6	2.72e-05	198	79	5	7896f9fb89822e8628fe0b90a489c4760c7b876c
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FRAS1 CDH26 CYP2F1 INSR FUT6	2.72e-05	198	79	5	fab3135f03cf23a9f04f0eed543a9dc181f39f5f
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MRPL23 CDH26 CYP2F1 NUCB2 FUT6	2.78e-05	199	79	5	73704e8d774b3d08a311f69137972b07015c38f6
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PKNOX2 UNC5C MEDAG STEAP2 FREM1	2.85e-05	200	79	5	cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PKNOX2 FRAS1 UNC5C STEAP2 FREM1	2.85e-05	200	79	5	34f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Ductal_and_Papillary_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	TBL1Y CLTC DDX42 AMZ2	1.04e-04	137	79	4	2a5d2a99a2c532480d00b80a4885514a8a5c80fa
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 SALL3 GRM2 ITGAD	1.22e-04	143	79	4	990844ca674d30b2924c74b45bed4fdfb8463fa7
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TYMS SCAMP5 VPS26B APOBEC3H	1.58e-04	153	79	4	0727dc70e16345645063c586d744bc4ac1710526
ToppCell	TCGA-Bone_and_Soft_Tissue-Solid_Tissue_Normal\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	ENPP7 CYP2B6 MIOX FUT6	1.62e-04	154	79	4	89a60a79d07466d7ad05888d10a72d3b1ab384af
ToppCell	TCGA-Bone_and_Soft_Tissue-Solid_Tissue_Normal-Connective_tissue_normal\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	ENPP7 CYP2B6 MIOX FUT6	1.62e-04	154	79	4	f1fea1a87e977221fa125b62287368be9af4987d
ToppCell	TCGA-Bone_and_Soft_Tissue-Solid_Tissue_Normal-Connective_tissue_normal-Connective_tissue_normal\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	ENPP7 CYP2B6 MIOX FUT6	1.62e-04	154	79	4	b5604c0b0b9b283352a3f612f40883b9123475d1
ToppCell	TCGA-Bone_and_Soft_Tissue-Solid_Tissue_Normal-Connective_tissue_normal-Connective_tissue_normal-1\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	ENPP7 CYP2B6 MIOX FUT6	1.62e-04	154	79	4	160b170a3ade8b246843c9854af332475c047ba0
ToppCell	severe_COVID-19-cDC\|World / disease group, cell group and cell class (v2)	POLE2 TEX38 UCK2 KIF17	1.71e-04	156	79	4	0a7e18ed8e13261c405eb6b9a183e99d8e1aac37
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 UNC5C CPS1 FREM1	1.88e-04	160	79	4	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 UNC5C CPS1 FREM1	1.88e-04	160	79	4	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CDH26 PGGHG CYP2F1 INSR	1.93e-04	161	79	4	2d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Kctd12\|Hippocampus / BrainAtlas - Mouse McCarroll V32	STK32B FREM1 L3MBTL4	2.01e-04	64	79	3	2edc3ae3e334bb04a411778e3b102b3a84a97824
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Kctd12-Inhibitory_Gad1Gad2Slc17a8_Htr3a.Ktcd12_(Interneuron,__GABA/Glutamate_co-releasing?_(candidate_CGE-derived_9))-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	STK32B FREM1 L3MBTL4	2.01e-04	64	79	3	b8aac6e83c2e5b09b55ea22ddb29940099f186e1
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Kctd12-Inhibitory_Gad1Gad2Slc17a8_Htr3a.Ktcd12_(Interneuron,__GABA/Glutamate_co-releasing?_(candidate_CGE-derived_9))\|Hippocampus / BrainAtlas - Mouse McCarroll V32	STK32B FREM1 L3MBTL4	2.01e-04	64	79	3	3e3eed30abcecd3fc8d30489dca05222ac353180
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 SALL3 ITGAD FREM1	2.07e-04	164	79	4	6fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Krt73-Inhibitory_Gad1Gad2_Htr3a.Krt73_(Interneuron,__(candidate_CGE-derived_8))-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	STK32B FREM1 L3MBTL4	2.10e-04	65	79	3	a3aac8aada31451c33165257773daaae676ad04e
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Krt73\|Hippocampus / BrainAtlas - Mouse McCarroll V32	STK32B FREM1 L3MBTL4	2.10e-04	65	79	3	02e778b500f62e5fb70e2f7d493a0280980e6a24
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Krt73-Inhibitory_Gad1Gad2_Htr3a.Krt73_(Interneuron,__(candidate_CGE-derived_8))\|Hippocampus / BrainAtlas - Mouse McCarroll V32	STK32B FREM1 L3MBTL4	2.10e-04	65	79	3	af69f27937e6c55ae937f16c418ff267c3ba6a8a
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor_MEMP\|bone_marrow / Manually curated celltypes from each tissue	TYMS HFM1 SYDE1 FREM1	2.16e-04	166	79	4	9788486582cc2c5f28b9ea015e235732f9fefb1e
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2F1 INSR NUCB2 FUT6	2.21e-04	167	79	4	31633899aae852873a4887e72c621474b0a51a33
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2F1 INSR FUT6 ITGAD	2.27e-04	168	79	4	b275e951ff7109e36da22fc17bd4516f9b9432c4
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2F1 INSR FUT6 ITGAD	2.27e-04	168	79	4	0757a5af953901a8faed5774ffec4755fc9c0a6e
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2F1 INSR FUT6 ITGAD	2.27e-04	168	79	4	a0dbe2ee697e29b32aa5f8326445e067ff66c154
ToppCell	Endothelial-B-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	STK32B MEDAG KIF17 FREM1	2.48e-04	172	79	4	8a527dff06d841a86c7eb04a1dd9630787294da4
ToppCell	facs-Marrow-T-cells-24m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCAMP5 STK32B NUCB2 ITGAD	2.53e-04	173	79	4	ca3d2a9562734f76127e3e7d54c10b63e95141bb
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CDH26 CYP2F1 NUCB2 FUT6	2.53e-04	173	79	4	e4d9a9a781acc531bc81c3fcee24d637e805c8e1
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_12\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TYMS INSR UCK2 CYP2S1	2.53e-04	173	79	4	a55f310c533432e9e26e400026a5b47245152976
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2F1 INSR NUCB2 FUT6	2.53e-04	173	79	4	3aa1d28d4814798a772808ed29e1dbbdf92abd03
ToppCell	facs-Marrow-T-cells-24m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCAMP5 STK32B NUCB2 ITGAD	2.53e-04	173	79	4	19a9e10885173d7712996be8660a3a5a7a9aa39f
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CDH26 CYP2F1 INSR STEAP2	2.53e-04	173	79	4	464267a2ff3f5c387b6c9c6fa4dab135a221f448
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_12\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TYMS INSR UCK2 CYP2S1	2.53e-04	173	79	4	9c7386bf0a899882c733f0b4921a96afde032a7d
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2F1 INSR NUCB2 FUT6	2.53e-04	173	79	4	e8afef5ae68983eb8d6515b43952636a47e9d3d4
ToppCell	Adult-Epithelial-lung_goblet_cell-D231\|Adult / Lineage, Cell type, age group and donor	FRAS1 CDH26 CYP2F1 INSR	2.59e-04	174	79	4	7d2f802f493f19a068e097b2909a9000e2160266
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PKNOX2 COMP UNC5C CREB3L2	2.70e-04	176	79	4	9bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PKNOX2 COMP UNC5C CREB3L2	2.70e-04	176	79	4	3f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MIOX INSR FUT6 SGK3	2.70e-04	176	79	4	1595dbeee336a81e581325d63208ec6262664ee9
ToppCell	metastatic_Lymph_Node-Endothelial_cells\|metastatic_Lymph_Node / Location, Cell class and cell subclass	GJA1 MEDAG KIF17 SYDE1	2.76e-04	177	79	4	71bf5d4bc67bda37a0499e5ec01af7dd5254041d
ToppCell	Adult-Epithelial-club_cell-D175\|Adult / Lineage, Cell type, age group and donor	FRAS1 CYP2B6 PGGHG INSR	2.76e-04	177	79	4	d652b7d84fe6aa38319d8d5adc72c70441bd0088
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MIOX INSR FUT6 L3MBTL4	2.76e-04	177	79	4	2f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCell	nucseq-Epithelial-Epithelial_Airway-Secretory/RAS\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYP2A7 CDH26 CYP2F1 INSR	2.76e-04	177	79	4	779ba86f53650772755b52460be03f18bb204e55
ToppCell	nucseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYP2A7 CDH26 CYP2F1 INSR	2.76e-04	177	79	4	0f210cfb61b873c5fd77dc17eadf4d017306500e
ToppCell	Children_(3_yrs)-Epithelial-basal_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRAS1 CYP2B6 CDH26 TBL1Y	2.82e-04	178	79	4	fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_12\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TYMS POLE2 UCK2 CYP2S1	2.82e-04	178	79	4	04bfecf5ea5d85c843e48d08718b5d69e7bf834e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 SALL3 UNC5C FREM1	2.88e-04	179	79	4	666072c0e8448dbaec1683d18368ec2502453f90
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRAS1 CYP2B6 CDH26 CYP2F1	2.95e-04	180	79	4	b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MIOX INSR FUT6 L3MBTL4	2.95e-04	180	79	4	1363b3254470f6ff98630d1df83a1bdbacc137e0
ToppCell	facs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PKNOX2 ALMS1 UNC5C STEAP2	2.95e-04	180	79	4	d33bb00f2b7d07dda9015cb8eafd742c2b2e9ace
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PKNOX2 FRAS1 UNC5C FREM1	3.01e-04	181	79	4	9ede19228ba5c0668a9c06c915510b95585216ef
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MIOX INSR FUT6 L3MBTL4	3.07e-04	182	79	4	4a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCell	droplet-Lung-nan-18m-Myeloid-Proliferating_Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TYMS DBF4 UCK2 CYP2S1	3.07e-04	182	79	4	11494a66d986297b837332ee9d382b71b9f22591
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRAS1 CYP2B6 CDH26 CYP2F1	3.07e-04	182	79	4	215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CDH26 CYP2F1 NUCB2 FUT6	3.07e-04	182	79	4	94e70746e35a3062015d4b83ee545f4f84f47420
ToppCell	facs-Kidney-nan-3m\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK1 GJA1 CLTC TACC1	3.07e-04	182	79	4	4c5d14e33ebdf117b5aa9e2f57aaa89aa51f72bf
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MIOX INSR FUT6 L3MBTL4	3.14e-04	183	79	4	84b64cf728629c3af9a8d2ed15b93adf562c54b8
ToppCell	Epithelial-lung_goblet_cell\|World / Lineage, Cell type, age group and donor	CDH26 CYP2F1 INSR FUT6	3.14e-04	183	79	4	940cbe298e9c53b5622af09264586ed823d3141f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 SALL3 UNC5C FREM1	3.14e-04	183	79	4	2e831a4d99c6f983793df71c0994124c943c6da9
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-Stromal_4_(MMP1+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	UNC5C HFM1 DZIP1 SYDE1	3.14e-04	183	79	4	269afec240a756eec3bbae5f30ec784281af3433
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COMP STK32B DZIP1 CPS1	3.20e-04	184	79	4	8fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
Drug	chloroacetyl chloride	TYMS CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.34e-06	55	79	5	CID000006577
Drug	trichloroacetic acid	TYMS CYP2A7 CYP2B6 CYP2F1 INSR CYP2S1	1.97e-06	107	79	6	CID000006421
Drug	C14845	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.22e-06	27	79	4	CID011954064
Drug	BP-9,10-oxide	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.22e-06	27	79	4	CID000037456
Drug	Brn 4136738	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.22e-06	27	79	4	CID000050331
Drug	9-OH-BaP-4,5-oxide	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.58e-06	28	79	4	CID000115064
Drug	11-H-14,15-EETA	CYP2A7 CYP2B6 CYP2F1 CYP2S1	3.43e-06	30	79	4	CID011954058
Drug	19-hydroxytestosterone	CYP2A7 CYP2B6 CYP2F1 CYP2S1	3.43e-06	30	79	4	CID000150968
Drug	BP-7,8-oxide	CYP2A7 CYP2B6 CYP2F1 CYP2S1	4.48e-06	32	79	4	CID000037455
Drug	12(13)-EpOME	CYP2A7 CYP2B6 CYP2F1 CYP2S1	5.75e-06	34	79	4	CID000001416
Drug	TCEO	CYP2A7 CYP2B6 CYP2F1 CYP2S1	5.75e-06	34	79	4	CID000028167
Drug	AC1O5XSP	CYP2A7 CYP2B6 CYP2F1 CYP2S1	5.75e-06	34	79	4	CID006442739
Drug	AC1L1CJI	CYP2A7 CYP2B6 CYP2F1 CYP2S1	6.48e-06	35	79	4	CID000001929
Drug	15-H-11,12-EETA	CYP2A7 CYP2B6 CYP2F1 CYP2S1	7.27e-06	36	79	4	CID011954042
Drug	AC1L3NGJ	CYP2A7 CYP2B6 CYP2F1 CYP2S1	7.27e-06	36	79	4	CID000092121
Drug	11,14,15-THET	CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.01e-05	39	79	4	CID006439531
Drug	Badg	CLTCL1 CLTC	1.19e-05	2	79	2	CID000125951
Drug	11,12,15-trihydroxyeicosatrienoic acid	CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.36e-05	42	79	4	CID006439610
Drug	N-Q-I	TYMS CLTCL1 CLTC	1.42e-05	14	79	3	CID015942689
Drug	NSC-343257	TYMS HEXB ENPP7 CLTCL1 INSR CLTC FUT6	1.45e-05	228	79	7	CID000004242
Drug	naphthalene-1,2-dihydrodiol	CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.80e-05	45	79	4	CID000000362
Drug	C14802	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.14e-05	47	79	4	CID011954053
Drug	C14800	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.33e-05	48	79	4	CID011954051
Drug	nitro-L	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.33e-05	48	79	4	CID000006849
Drug	19-HETE	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.53e-05	49	79	4	CID006439528
Drug	bromobenzene-3,4-oxide	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.53e-05	49	79	4	CID000108121
Drug	bromobenzene-2,3-oxide	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.74e-05	50	79	4	CID003036760
Drug	6-hydroxymelatonin	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.74e-05	50	79	4	CID000001864
Drug	1,1-dichloroethylene epoxide	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.74e-05	50	79	4	CID000119521
Drug	naphthalene epoxide	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.96e-05	51	79	4	CID000108063
Drug	9-hydroxybenzo(a)pyrene	CYP2A7 CYP2B6 CYP2F1 CYP2S1	3.45e-05	53	79	4	CID000028598
Drug	AQ4N	CYP2B6 CYP2S1	3.56e-05	3	79	2	ctd:C094428
Drug	dichloroacetaldehyde	CYP2A7 CYP2B6 CYP2F1 CYP2S1	3.72e-05	54	79	4	CID000006576
Drug	1,2-dihydroxynaphthalene	CYP2A7 CYP2B6 CYP2F1 CYP2S1	4.61e-05	57	79	4	CID000011318
Drug	bromoacetaldehyde	CYP2A7 CYP2B6 CYP2F1 CYP2S1	4.94e-05	58	79	4	CID000105131
Drug	1,1-dichloroethylene	CYP2A7 CYP2B6 CYP2F1 CYP2S1	5.65e-05	60	79	4	CID000006366
Drug	AC1L19SN	TYMS CLTCL1 CLTC UCK2	5.65e-05	60	79	4	CID000000687
Drug	alprazolam	CYP2A7 CYP2B6 COMP CYP2F1 CYP2S1 GRM2	5.71e-05	193	79	6	CID000002118
Drug	Parbendazole [14255-87-9]; Up 200; 16.2uM; PC3; HT_HG-U133A	PKNOX2 CPNE6 CLTCL1 CLUL1 FUT6 KIF17	5.87e-05	194	79	6	3799_UP
Drug	BP-4,5-oxide	CYP2A7 CYP2B6 CYP2F1 CYP2S1	6.03e-05	61	79	4	CID000037786
Drug	Practolol [6673-35-4]; Up 200; 15uM; MCF7; HT_HG-U133A	CYP2B6 TBL1Y INSR FUT6 KIF17 DNMT3A	6.40e-05	197	79	6	5664_UP
Drug	Fenbufen [36330-85-5]; Up 200; 15.8uM; PC3; HT_HG-U133A	PGGHG TBL1Y FUT6 NPHP4 KIF17 DNMT3A	6.58e-05	198	79	6	3721_UP
Drug	Flurbiprofen [5104-49-4]; Up 200; 16.4uM; MCF7; HT_HG-U133A	PKNOX2 CYP2B6 LLGL1 TBL1Y SYDE1 DNMT3A	6.95e-05	200	79	6	5634_UP
Drug	AC1OAR8J	CLTCL1 CLTC	7.10e-05	4	79	2	CID006834124
Drug	propoxyphene	CYP2A7 CYP2B6 CYP2F1 CYP2S1	8.72e-05	67	79	4	CID000010100
Drug	5-fluorocytidine	TYMS UCK2 DNMT3A	8.75e-05	25	79	3	CID000016861
Drug	5,6-epoxyeicosatrienoic acid	CYP2A7 CYP2B6 CYP2F1 CYP2S1	9.24e-05	68	79	4	CID000001778
Drug	8(9)-EET	CYP2A7 CYP2B6 CYP2F1 CYP2S1	9.78e-05	69	79	4	CID000001901
Drug	1h1q	TYMS CYP2A7 CYP2B6 CYP2F1	1.03e-04	70	79	4	CID000001540
Drug	4-bromophenol	CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.03e-04	70	79	4	CID000007808
Drug	1,2-dibromoethane	CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.09e-04	71	79	4	CID000007839
Drug	carteolol	CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.15e-04	72	79	4	CID000002583
Drug	5-mercaptodeoxyuridine	TYMS UCK2	1.18e-04	5	79	2	CID000099529
Drug	2,2,2-trichloroethanol	CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.22e-04	73	79	4	CID000008259
Drug	chloral	CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.22e-04	73	79	4	CID000006407
Drug	AC1Q6S3S	TYMS LLGL1 POLE2 APOBEC3H UCK2	1.37e-04	142	79	5	CID000001151
Drug	NSC406942	TYMS GJA1 CLTCL1 SCAMP5 POLE2 INSR CLTC SRP54 CYP2S1	1.47e-04	565	79	9	CID000001115
Drug	melatonin	GJA1 CYP2A7 CYP2B6 LLGL1 CYP2F1 INSR CYP2S1 GRM2	1.50e-04	443	79	8	CID000000896
Drug	AC1LAHG0	TYMS APOBEC3H UCK2	1.53e-04	30	79	3	CID000513869
Drug	C20H32O4	CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.58e-04	78	79	4	CID000001440
Drug	BP-7,8-diol	CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.58e-04	78	79	4	CID000025892
Drug	trimipramine	CYP2A7 CYP2B6 CYP2F1 CYP2S1	1.74e-04	80	79	4	CID000005584
Drug	mV GABA	GLRB MED12	1.77e-04	6	79	2	CID000128435
Drug	putThy	TYMS CLTC	1.77e-04	6	79	2	CID000188337
Drug	AC1L1IPS	CLTCL1 CLTC	1.77e-04	6	79	2	CID000004682
Drug	cyclopentenyl	TYMS UCK2 GRM2	1.85e-04	32	79	3	CID000139193
Drug	hydroxyl radicals	TYMS HEXB USP26 CYP2A7 ENPP7 CYP2B6 PDE6A MIOX CYP2F1 CLTC SRP54 CYP2S1 CPS1 ATP4B	1.91e-04	1341	79	14	CID000000961
Drug	GTP[S]	DOCK1 TYMS ARFGAP2 CLTCL1 TBL1Y INSR CLTC SRP54 GRM2	2.06e-04	591	79	9	CID000001764
Drug	diosmetin	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.20e-04	85	79	4	CID005281612
Drug	PiMM	HEXB CLTCL1 CLTC	2.43e-04	35	79	3	CID000110719
Drug	Dynasore hydrate	CLTCL1 CLTC	2.47e-04	7	79	2	CID005396227
Drug	Lucifer yellow VS	GJA1 COMP	2.47e-04	7	79	2	CID000435216
Drug	C12-NBD-PC	CLTCL1 CLTC	2.47e-04	7	79	2	CID006439314
Drug	propyl methanethiosulfonate	TYMS GLRB	2.47e-04	7	79	2	CID000529387
Drug	trichloroethylene	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.51e-04	88	79	4	CID000006575
Drug	mephenytoin	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.51e-04	88	79	4	CID000004060
Drug	14(15)-EpETrE	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.62e-04	89	79	4	CID000001431
Drug	parathion	CYP2A7 CYP2B6 CYP2F1 CYP2S1	2.85e-04	91	79	4	CID000000991
Drug	felodipine	TYMS CYP2A7 CYP2B6 CYP2F1 CYP2S1	3.07e-04	169	79	5	CID000003333
Drug	2-naphthol	CYP2A7 CYP2B6 CYP2F1 CYP2S1	3.10e-04	93	79	4	CID000008663
Drug	tienilic acid	CYP2A7 CYP2B6 CYP2F1 CYP2S1	3.10e-04	93	79	4	CID000038409
Drug	AC1L1BEQ	CYP2A7 CYP2B6 CYP2F1 CYP2S1	3.10e-04	93	79	4	CID000001407
Drug	lansoprazole	CYP2A7 CYP2B6 CYP2F1 CYP2S1	3.10e-04	93	79	4	CID000003883
Drug	Na 7	CLTCL1 CLTC	3.28e-04	8	79	2	CID000446006
Drug	PtdIns(3)P	CLTCL1 VPS26B INSR CLTC SGK3	3.61e-04	175	79	5	CID000643964
Drug	bromobenzene	CYP2A7 CYP2B6 CYP2F1 CYP2S1	3.64e-04	97	79	4	CID000007961
Drug	L000369	CLTCL1 CLTC GRM2	3.90e-04	41	79	3	CID003931705
Disease	sensory system disease (implicated_via_orthology)	TBL1Y TBL1XR1	2.01e-05	3	77	2	DOID:0050155 (implicated_via_orthology)
Disease	Fraser syndrome (implicated_via_orthology)	FRAS1 FREM1	4.02e-05	4	77	2	DOID:0090001 (implicated_via_orthology)
Disease	brain cancer (implicated_via_orthology)	LLGL1 VPS26B L3MBTL4	4.25e-05	26	77	3	DOID:1319 (implicated_via_orthology)
Disease	polybrominated biphenyl measurement, gestational serum measurement, polybrominated diphenyl ether measurement	CYP2B6 TACC1	6.69e-05	5	77	2	EFO_0007961, EFO_0007962, EFO_0007964
Disease	Hyperammonemia	TYMS CPS1	1.40e-04	7	77	2	C0220994
Disease	Unilateral agenesis of kidney	FRAS1 FREM1	1.86e-04	8	77	2	C0266294
Disease	Disorder of eye	FRAS1 PDE6A ALMS1 NPHP4 FREM1	2.37e-04	212	77	5	C0015397
Disease	alkaline phosphatase measurement	CYP2A7 CYP2B6 LLGL1 PGGHG EIF2B2 HFM1 CPS1 FUT6 KIF17 CREB3L2	3.02e-04	1015	77	10	EFO_0004533
Disease	nicotine metabolite ratio	CYP2A7 CYP2B6	4.36e-04	12	77	2	EFO_0007794
Disease	Mammary Carcinoma, Human	TYMS GJA1 LLGL1 PDPK1 CLUL1 MED12 DNMT3A	4.45e-04	525	77	7	C4704874
Disease	Mammary Neoplasms, Human	TYMS GJA1 LLGL1 PDPK1 CLUL1 MED12 DNMT3A	4.45e-04	525	77	7	C1257931
Disease	Mammary Neoplasms	TYMS GJA1 LLGL1 PDPK1 CLUL1 MED12 DNMT3A	4.56e-04	527	77	7	C1458155
Disease	Breast Carcinoma	TYMS GJA1 LLGL1 PDPK1 CLUL1 MED12 DNMT3A	5.15e-04	538	77	7	C0678222
Disease	gliosarcoma	CYP2B6 TACC1	7.88e-04	16	77	2	C0206726
Disease	Testicular Germ Cell Tumor	PKNOX2 UCK2 CLUL1	9.32e-04	73	77	3	EFO_1000566
Disease	Congenital hernia of foramen of Morgagni	INSR FREM1	1.12e-03	19	77	2	C0265699
Disease	Congenital hernia of foramen of Bochdalek	INSR FREM1	1.12e-03	19	77	2	C0265700
Disease	caffeine metabolite measurement	CYP2A7 CYP2B6	1.12e-03	19	77	2	EFO_0007872
Disease	Prostatic Neoplasms	TYMS GJA1 NUCB2 NDST4 UCK2 TBL1XR1 MED12	1.14e-03	616	77	7	C0033578
Disease	Malignant neoplasm of prostate	TYMS GJA1 NUCB2 NDST4 UCK2 TBL1XR1 MED12	1.14e-03	616	77	7	C0376358
Disease	diet measurement, body mass index	DOCK1 TBL1XR1	1.24e-03	20	77	2	EFO_0004340, EFO_0008111
Disease	Congenital diaphragmatic hernia	INSR FREM1	1.37e-03	21	77	2	C0235833
Disease	acute myeloid leukemia (is_implicated_in)	TYMS CYP2B6 DNMT3A	1.40e-03	84	77	3	DOID:9119 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
HFDPDNFDESMDPFK	TACC1	416	O75410
FGEDNFPKQVFADDP	USP26	411	Q9BXU7
KAIFKFDSNHNPEEP	ERBIN	941	Q96RT1
YFEKPDAFNPDHFLD	CYP2B6	401	P20813
QMFFANNHDQEFDPP	DNMT3A	606	Q9Y6K1
PQKSNPDQADVDHDF	COMP	411	P49747
VKFDAPFRPADTHNE	GRM2	426	Q14416
ENFVDHEKPLSFNPY	APOBEC3H	146	Q6NTF7
HSPFQNFIPDEFKIS	ALMS1	2651	Q8TCU4
EDQVFHVNAFGFPPT	POLE2	231	P56282
AVPNHSPEKKDSDFF	ARFGAP2	141	Q8N6H7
TSHPEAPQDFEQFFS	AMZ2	61	Q86W34
TFNNPHDPYEGKVEF	ATP4B	271	P51164
FHTPPEEPNECDFKN	DBF4	551	Q9UBU7
EVNGKQHEPLSFFFD	FAM193A	1021	P78312
FSEEKFHFSDKPQPD	BAZ1A	936	Q9NRL2
IPPNFEVSHDFAINF	CPNE6	366	O95741
QFLTPQEFNPEHFLD	CYP2F1	401	P24903
ELFAFNKTVEHGFPN	LLGL1	21	Q15334
PHFFLDFENAQPTEG	CYRIA	16	Q9H0Q0
QPEVTDKYFHDVPFE	FRAS1	3766	Q86XX4
HDPNIFKHPEEFNPD	CYP2S1	401	Q96SQ9
FKHPEEFNPDRFLDA	CYP2S1	406	Q96SQ9
PPFEKNFYNEHEEIT	DDX42	211	Q86XP3
PFQAFPADKVVSLFH	OR4N5	261	Q8IXE1
NAPAEDFFAFQKEPL	PDE6A	361	P16499
FSKDFSENKQPANPH	FREM1	1201	Q5H8C1
FPEEEFDGHQFQKTQ	IFNA7	61	P01567
FSKDQSFPEHENGFQ	L3MBTL4	71	Q8NA19
EAFPTAEDIFAKFQH	MED12	821	Q93074
PDLFFANEKSANFHD	GLRB	141	P48167
PSFPEVSFFHSEENK	INSR	1296	P06213
VPFDVEQNFHPEFDG	PGGHG	476	Q32M88
LAHQYFELFPEQKDP	NDST4	556	Q9H3R1
QFPSSDVEFLPKEFQ	MROH9	221	Q5TGP6
PNDFDPKTFFKLHDV	NUCB2	241	P80303
LQFDFQEAVKNFFPP	MEDAG	166	Q5VYS4
GVAEFFEFVLKNPHN	NPHP4	986	O75161
NIPHEAFVYQKDSDP	PANK4	161	Q9NVE7
FKAPSFSVAFQPHDI	HFM1	236	A2PYH4
APPQDHVFKVDNFAA	ITGAD	306	Q13349
HESKPFFAVQFHPEV	CPS1	366	P31327
DDEDKQHFIPFQPVA	DOCK1	341	Q14185
SNPQDFNPQHFLDDK	CYP2A7	406	P20853
HAQPFDFPDDNQNSK	GJA1	331	P17302
TQFVNFFGDKTDFHP	DNAAF9	1126	Q5TEA3
PDAFIHVDDFQSPKD	FUT6	286	P51993
FKTQADPREPQFHAF	DENND5A	106	Q6IQ26
SDVNDHAPQFPEKEF	CDH26	156	Q8IXH8
PQFPNEEDSFHKFVA	EIF2B2	276	P49770
KKEAFPEAFHYANNP	ENPP7	311	Q6UWV6
FFKEISEVFPDQFIH	HEXB	336	P07686
FYQDFEADIPPQHVS	SCAMP5	21	Q8TAC9
VFEPKASAEDPFFKH	SALL3	406	Q9BXA9
AKEDFLEIQNHPFFE	SGK3	406	Q96BR1
QEQEHKPFFSDDPEL	PKNOX2	116	Q96KN3
QDPKNPEHVKTFTFD	KIF28P	41	B7ZC32
PHEVDQFLNFSPKEA	CREB3L2	181	Q70SY1
DEPPKQFTFDGAYHV	KIF17	46	Q9P2E2
ESDPDVDFPNSFHAF	MIOX	86	Q9UGB7
DDFDAPFNPHLNLKD	SYDE1	701	Q6ZW31
GEHIDDFEPFKTQPF	SRP54	276	P61011
PEAKNFKTFFVHTPN	PDPK1	506	O15530
KAPSNTFHPQDFSDV	SMG1	851	Q96Q15
RNPKFASEFFPHVVD	STEAP2	61	Q8NFT2
AHEFKEDRSPYPQDF	DZIP1	346	Q86YF9
KQQFPFHSAPALDVD	TBL1XR1	301	Q9BZK7
KAVDVFFPPEAQNDF	CLTC	246	Q00610
KAVDVFFPPEAQNDF	CLTCL1	246	P53675
QFLFPFHEDNEKDLP	CLUL1	151	Q15846
QSQAFDFEFTHVEKP	VPS26B	101	Q4G0F5
HGQTFTFPDLFPEKD	MRPL23	101	Q16540
FKAEDFQIEGYNPHP	TYMS	291	P04818
ALKGQFNFDHPDAFD	UCK2	76	Q9BZX2
KQQFPFHSAPALDVD	TBL1Y	311	Q9BQ87
DDFNVFDNFFLHSKP	ZNF84	156	P51523
DDEVFKPFQANSHFV	TMEM81	131	Q6P7N7
SHKPPVFDENEEVNF	STK32B	6	Q9NY57
QDDDFFHELPETFPS	UNC5C	41	O95185
AQEDHSFNAKPFPSE	TEX38	191	Q6PEX7