Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	negative regulation of long-chain fatty acid import across plasma membrane	AKT1 AKT2	3.04e-05	4	47	2	GO:0010748
GeneOntologyBiologicalProcess	negative regulation of long-chain fatty acid import into cell	AKT1 AKT2	3.04e-05	4	47	2	GO:0140213
GeneOntologyCellularComponent	axoneme	WDR11 GLI3 DZIP1L AKAP14 CFAP210	1.10e-04	207	48	5	GO:0005930
GeneOntologyCellularComponent	ciliary plasm	WDR11 GLI3 DZIP1L AKAP14 CFAP210	1.12e-04	208	48	5	GO:0097014
GeneOntologyCellularComponent	cell cortex	HMCN1 SPTBN1 FGB AKT1 AKT2 SEPTIN12	1.96e-04	371	48	6	GO:0005938
GeneOntologyCellularComponent	plasma membrane bounded cell projection cytoplasm	WDR11 GLI3 DZIP1L AKAP14 CFAP210	7.80e-04	317	48	5	GO:0032838
GeneOntologyCellularComponent	cilium	WDR11 GLI3 DZIP1L AKAP14 AKT1 CFAP210 CFAP44 SEPTIN12	9.21e-04	898	48	8	GO:0005929
Domain	WD40_repeat_CS	FBXW10B FBXW10 WDR11 CFAP44	7.62e-04	164	47	4	IPR019775
Domain	Actinin_actin-bd_CS	SYNE1 SPTBN1	1.52e-03	23	47	2	IPR001589
Domain	Spectrin	SYNE1 SPTBN1	1.52e-03	23	47	2	PF00435
Domain	ACTININ_2	SYNE1 SPTBN1	1.52e-03	23	47	2	PS00020
Domain	ACTININ_1	SYNE1 SPTBN1	1.52e-03	23	47	2	PS00019
Domain	Spectrin_repeat	SYNE1 SPTBN1	2.41e-03	29	47	2	IPR002017
Domain	-	RANBP2 SPTBN1 ARHGEF12 AKT1 AKT2	2.92e-03	391	47	5	2.30.29.30
Domain	Spectrin/alpha-actinin	SYNE1 SPTBN1	2.93e-03	32	47	2	IPR018159
Domain	SPEC	SYNE1 SPTBN1	2.93e-03	32	47	2	SM00150
Domain	Pkinase_C	AKT1 AKT2	3.90e-03	37	47	2	IPR017892
Domain	WD40	FBXW10B FBXW10 WDR11 CFAP44	4.04e-03	259	47	4	PF00400
Domain	PH_dom-like	RANBP2 SPTBN1 ARHGEF12 AKT1 AKT2	4.21e-03	426	47	5	IPR011993
Domain	RGS	RGSL1 ARHGEF12	4.33e-03	39	47	2	IPR016137
Domain	WD40	FBXW10B FBXW10 WDR11 CFAP44	4.56e-03	268	47	4	SM00320
Domain	WD40_repeat	FBXW10B FBXW10 WDR11 CFAP44	4.80e-03	272	47	4	IPR001680
Domain	Pkinase_C	AKT1 AKT2	5.01e-03	42	47	2	PF00433
Domain	PH	SPTBN1 ARHGEF12 AKT1 AKT2	5.18e-03	278	47	4	SM00233
Domain	WD_REPEATS_1	FBXW10B FBXW10 WDR11 CFAP44	5.18e-03	278	47	4	PS00678
Domain	WD_REPEATS_2	FBXW10B FBXW10 WDR11 CFAP44	5.25e-03	279	47	4	PS50082
Domain	WD_REPEATS_REGION	FBXW10B FBXW10 WDR11 CFAP44	5.25e-03	279	47	4	PS50294
Domain	PH_DOMAIN	SPTBN1 ARHGEF12 AKT1 AKT2	5.25e-03	279	47	4	PS50003
Domain	PH_domain	SPTBN1 ARHGEF12 AKT1 AKT2	5.32e-03	280	47	4	IPR001849
Domain	WD40_repeat_dom	FBXW10B FBXW10 WDR11 CFAP44	6.53e-03	297	47	4	IPR017986
Domain	AGC-kinase_C	AKT1 AKT2	8.75e-03	56	47	2	IPR000961
Domain	AGC_KINASE_CTER	AKT1 AKT2	8.75e-03	56	47	2	PS51285
Domain	S_TK_X	AKT1 AKT2	8.75e-03	56	47	2	SM00133
Domain	Znf_C3HC4_RING-type	TRIM67 RNF103 RNF187	9.25e-03	172	47	3	IPR018957
Domain	-	FBXW10B FBXW10 WDR11 CFAP44	9.69e-03	333	47	4	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	FBXW10B FBXW10 WDR11 CFAP44	9.89e-03	335	47	4	IPR015943
Pathway	KEGG_MEDICUS_VARIANT_LOSS_OF_NKX3_1_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	5.29e-05	5	33	2	M48999
Pathway	KEGG_MEDICUS_REFERENCE_MAGI_PTEN_SIGNALING_PATHWAY	AKT1 AKT2	7.92e-05	6	33	2	M47523
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PI3K_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.11e-04	7	33	2	M47407
Pathway	KEGG_MEDICUS_REFERENCE_ACH_CHRN_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.11e-04	7	33	2	M47790
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.47e-04	8	33	2	M47399
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_EGFR_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.47e-04	8	33	2	M47394
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.47e-04	8	33	2	M47395
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.47e-04	8	33	2	M47404
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.47e-04	8	33	2	M47405
Pathway	KEGG_MEDICUS_REFERENCE_P4_PR_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.47e-04	8	33	2	M47803
Pathway	REACTOME_RUNX2_REGULATES_GENES_INVOLVED_IN_CELL_MIGRATION	AKT1 AKT2	1.47e-04	8	33	2	M27806
Pathway	KEGG_MEDICUS_VARIANT_TGFA_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.47e-04	8	33	2	M47482
Pathway	KEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.47e-04	8	33	2	M47498
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_RET_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.47e-04	8	33	2	M47715
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.89e-04	9	33	2	M47397
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.89e-04	9	33	2	M47392
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.89e-04	9	33	2	M47391
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.89e-04	9	33	2	M47402
Pathway	KEGG_MEDICUS_REFERENCE_MEMBRANE_INITIATED_PROGESTERONE_SIGNALING_PATHWAY	AKT1 AKT2	1.89e-04	9	33	2	M47802
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_MET_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.89e-04	9	33	2	M47490
Pathway	KEGG_MEDICUS_REFERENCE_TGFA_EGFR_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.89e-04	9	33	2	M47481
Pathway	REACTOME_ESTROGEN_DEPENDENT_NUCLEAR_EVENTS_DOWNSTREAM_OF_ESR_MEMBRANE_SIGNALING	AKT1 AKT2	1.89e-04	9	33	2	MM15666
Pathway	KEGG_MEDICUS_REFERENCE_ICOSLG_ICOS_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.89e-04	9	33	2	M47972
Pathway	KEGG_MEDICUS_VARIANT_EGFR_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	2.36e-04	10	33	2	M47400
Pathway	KEGG_MEDICUS_REFERENCE_HGF_MET_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	2.36e-04	10	33	2	M47401
Pathway	KEGG_MEDICUS_REFERENCE_CD80_CD86_CD28_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	2.36e-04	10	33	2	M47615
Pathway	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_NUCLEUS	AKT1 AKT2	2.36e-04	10	33	2	M27095
Pathway	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_NUCLEUS	AKT1 AKT2	2.36e-04	10	33	2	MM14778
Pathway	KEGG_MEDICUS_ENV_FACTOR_NICOTINE_NNK_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	2.88e-04	11	33	2	M47797
Pathway	KEGG_MEDICUS_REFERENCE_KITLG_KIT_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	2.88e-04	11	33	2	M47403
Pathway	KEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	2.88e-04	11	33	2	M47406
Pathway	KEGG_MEDICUS_REFERENCE_IGF2_IGF1R_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	2.88e-04	11	33	2	M47484
Pathway	KEGG_MEDICUS_REFERENCE_EREG_EGFR_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	2.88e-04	11	33	2	M47499
Pathway	KEGG_MEDICUS_REFERENCE_NRG_ERBB4_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	2.88e-04	11	33	2	M47756
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01339	AKT1 AKT2	2.88e-04	11	33	2	M47791
Pathway	KEGG_MEDICUS_REFERENCE_AREG_EGFR_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	2.88e-04	11	33	2	M47501
Pathway	KEGG_MEDICUS_VARIANT_ERBB2_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	3.46e-04	12	33	2	M47393
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01350	AKT1 AKT2	3.46e-04	12	33	2	M47798
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY	AKT1 AKT2	3.46e-04	12	33	2	M47558
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY	AKT1 AKT2	3.46e-04	12	33	2	M47559
Pathway	REACTOME_SARS_COV_2_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS	AKT1 AKT2	3.46e-04	12	33	2	M45022
Pathway	REACTOME_REGULATION_OF_LOCALIZATION_OF_FOXO_TRANSCRIPTION_FACTORS	AKT1 AKT2	3.46e-04	12	33	2	MM15657
Pathway	REACTOME_REGULATION_OF_LOCALIZATION_OF_FOXO_TRANSCRIPTION_FACTORS	AKT1 AKT2	3.46e-04	12	33	2	M27939
Pathway	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL	AKT1 AKT2	3.46e-04	12	33	2	MM14777
Pathway	REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING	AKT1 AKT2	3.46e-04	12	33	2	MM14550
Pathway	KEGG_COLORECTAL_CANCER	AKT1 AKT2 DCC	4.02e-04	62	33	3	M14631
Pathway	KEGG_MEDICUS_REFERENCE_PDGF_PDGFR_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	4.08e-04	13	33	2	M47398
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGF1R_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	4.08e-04	13	33	2	M47603
Pathway	REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING	AKT1 AKT2	4.08e-04	13	33	2	M549
Pathway	WP_ENDOCHONDRAL_OSSIFICATION_WITH_SKELETAL_DYSPLASIAS	GLI3 FRZB AKT1	4.22e-04	63	33	3	M39884
Pathway	WP_ENDOCHONDRAL_OSSIFICATION	GLI3 FRZB AKT1	4.22e-04	63	33	3	M39646
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	4.75e-04	14	33	2	M47390
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ASSOCIATION_WITH_CO_FACTORS	AKT1 AKT2	4.75e-04	14	33	2	MM15341
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ASSOCIATION_WITH_CO_FACTORS	AKT1 AKT2	4.75e-04	14	33	2	M27638
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGFR_PI3K_NFKB_SIGNALING_PATHWAY	AKT1 AKT2	4.75e-04	14	33	2	M47467
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_NFKB_SIGNALING_PATHWAY	AKT1 AKT2	4.75e-04	14	33	2	M47536
Pathway	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL	AKT1 AKT2	4.75e-04	14	33	2	M3862
Pathway	WP_ENDOCHONDRAL_OSSIFICATION	GLI3 FRZB AKT1	4.84e-04	66	33	3	MM15875
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	5.47e-04	15	33	2	M47389
Pathway	KEGG_MEDICUS_REFERENCE_RELN_VLDLR_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	5.47e-04	15	33	2	M47663
Pathway	REACTOME_ACTIVATION_OF_BAD_AND_TRANSLOCATION_TO_MITOCHONDRIA	AKT1 AKT2	5.47e-04	15	33	2	M26902
Pathway	WP_TRANSCRIPTION_FACTORS_REGULATE_MIRNAS_RELATED_TO_CARDIAC_HYPERTROPHY	AKT1 AKT2	5.47e-04	15	33	2	M39431
Pathway	KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	5.47e-04	15	33	2	M47475
Pathway	WP_RIOK1_AND_RIOK2_IN_EGFR_AND_PI3KMEDIATED_TUMORIGENESIS	AKT1 AKT2	5.47e-04	15	33	2	M48306
Pathway	KEGG_MEDICUS_REFERENCE_BCR_BCAP_CD19_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	5.47e-04	15	33	2	M47971
Pathway	WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER	AKT1 AKT2 DCC	6.50e-04	73	33	3	M39758
Pathway	WP_INVOLVEMENT_OF_SECRETASE_IN_NEURODEGENERATIVE_DISEASES	AKT1 AKT2	7.07e-04	17	33	2	M48086
Pathway	SA_PTEN_PATHWAY	AKT1 AKT2	7.07e-04	17	33	2	M12771
Pathway	SA_TRKA_RECEPTOR	AKT1 AKT2	7.07e-04	17	33	2	M18895
Pathway	KEGG_PATHWAYS_IN_CANCER	GLI3 LAMA2 AKT1 AKT2 DCC	8.82e-04	325	33	5	M12868
Pathway	WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION	AKT1 AKT2	8.86e-04	19	33	2	M39370
Pathway	KEGG_MEDICUS_REFERENCE_PP2A_AKT_SIGNALING_PATHWAY	AKT1 AKT2	8.86e-04	19	33	2	M47525
Pathway	KEGG_SMALL_CELL_LUNG_CANCER	LAMA2 AKT1 AKT2	9.79e-04	84	33	3	M3228
Pathway	WP_CANCER_PATHWAYS	GLI3 LAMA2 ARHGEF12 AKT1 AKT2 DCC	1.02e-03	507	33	6	M48302
Pathway	REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS	AKT1 AKT2	1.09e-03	21	33	2	M14966
Pathway	REACTOME_CTLA4_INHIBITORY_SIGNALING	AKT1 AKT2	1.09e-03	21	33	2	M5876
Pathway	PID_ECADHERIN_KERATINOCYTE_PATHWAY	AKT1 AKT2	1.09e-03	21	33	2	M184
Pathway	REACTOME_CTLA4_INHIBITORY_SIGNALING	AKT1 AKT2	1.09e-03	21	33	2	MM14996
Pathway	REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING	AKT1 AKT2	1.19e-03	22	33	2	M13897
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION	AKT1 AKT2	1.19e-03	22	33	2	MM15656
Pathway	KEGG_MEDICUS_REFERENCE_CD80_CD86_CTLA4_PP2A_SIGNALING_PATHWAY	AKT1 AKT2	1.19e-03	22	33	2	M47919
Pathway	WP_SIGNAL_TRANSDUCTION_OF_S1P_RECEPTOR	AKT1 AKT2	1.30e-03	23	33	2	MM15952
Pathway	WP_SILDENAFIL_TREATMENT	AKT1 AKT2	1.30e-03	23	33	2	M46455
Pathway	REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING	AKT1 AKT2	1.30e-03	23	33	2	MM14993
Pathway	REACTOME_ESTROGEN_DEPENDENT_NUCLEAR_EVENTS_DOWNSTREAM_OF_ESR_MEMBRANE_SIGNALING	AKT1 AKT2	1.42e-03	24	33	2	M27952
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_VGPCR_TO_GNB_G_PI3K_AKT_SIGNALING_PATHWAY	AKT1 AKT2	1.42e-03	24	33	2	M47460
Pathway	WP_SMALL_CELL_LUNG_CANCER	LAMA2 AKT1 AKT2	1.44e-03	96	33	3	M39834
Pathway	WP_REGULATION_OF_APOPTOSIS_BY_PARATHYROID_HORMONERELATED_PROTEIN	AKT1 AKT2	1.54e-03	25	33	2	M39533
Pathway	WP_RELATIONSHIP_BETWEEN_INFLAMMATION_COX2_AND_EGFR	AKT1 AKT2	1.54e-03	25	33	2	M39794
Pathway	WP_S1P_RECEPTOR_SIGNAL_TRANSDUCTION	AKT1 AKT2	1.54e-03	25	33	2	M39384
Pathway	REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA	AKT1 AKT2	1.54e-03	25	33	2	M14301
Pathway	PID_INSULIN_GLUCOSE_PATHWAY	AKT1 AKT2	1.67e-03	26	33	2	M247
Pathway	REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA	AKT1 AKT2	1.67e-03	26	33	2	MM15017
Pathway	REACTOME_CONSTITUTIVE_SIGNALING_BY_AKT1_E17K_IN_CANCER	AKT1 AKT2	1.67e-03	26	33	2	M27558
Pathway	REACTOME_DOWNREGULATION_OF_ERBB2_SIGNALING	AKT1 AKT2	1.67e-03	26	33	2	MM15501
Pathway	WP_GROWTH_FACTORS_AND_HORMONES_IN_BETA_CELL_PROLIFERATION	AKT1 AKT2	1.67e-03	26	33	2	M48092
Pathway	KEGG_MEDICUS_REFERENCE_CXCR_GNB_G_PI3K_AKT_SIGNALING_PATHWAY	AKT1 AKT2	1.67e-03	26	33	2	M47456
Pathway	REACTOME_VEGFR2_MEDIATED_VASCULAR_PERMEABILITY	AKT1 AKT2	1.80e-03	27	33	2	M27422
Pathway	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	AKT1 AKT2	1.80e-03	27	33	2	M1718
Pathway	REACTOME_INTEGRIN_SIGNALING	FGB AKT1	1.80e-03	27	33	2	M760
Pubmed	Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system.	LAMA2 AKT1 AKT2	6.09e-07	12	50	3	24687281
Pubmed	Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells.	AKT1 AKT2	2.03e-06	2	50	2	27878243
Pubmed	BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models.	AKT1 AKT2	2.03e-06	2	50	2	27699769
Pubmed	Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition.	AKT1 AKT2	2.03e-06	2	50	2	16365168
Pubmed	Isoform-Specific Role of Akt in Oral Squamous Cell Carcinoma.	AKT1 AKT2	2.03e-06	2	50	2	31252679
Pubmed	Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma.	AKT1 AKT2	2.03e-06	2	50	2	15102693
Pubmed	AKT1 and AKT2 induce distinct phosphorylation patterns in HL-1 cardiac myocytes.	AKT1 AKT2	2.03e-06	2	50	2	25162660
Pubmed	The Akt1 isoform is an essential mediator of ischaemic preconditioning.	AKT1 AKT2	2.03e-06	2	50	2	22117619
Pubmed	Akt1 is critical for acute inflammation and histamine-mediated vascular leakage.	AKT1 AKT2	2.03e-06	2	50	2	19622728
Pubmed	Expression of AKT1 along with AKT2 in granulosa-lutein cells of hyperandrogenic PCOS patients.	AKT1 AKT2	2.03e-06	2	50	2	28271235
Pubmed	Distinct actions of Akt1 and Akt2 in skeletal muscle differentiation.	AKT1 AKT2	2.03e-06	2	50	2	19142853
Pubmed	Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors.	AKT1 AKT2	2.03e-06	2	50	2	15545269
Pubmed	Role of Akt in cardiac growth and metabolism.	AKT1 AKT2	2.03e-06	2	50	2	17019809
Pubmed	Loss of PKBβ/Akt2 predisposes mice to ovarian cyst formation and increases the severity of polycystic ovary formation in vivo.	AKT1 AKT2	2.03e-06	2	50	2	22275470
Pubmed	Specific and redundant roles of PKBα/AKT1 and PKBβ/AKT2 in human pancreatic islets.	AKT1 AKT2	2.03e-06	2	50	2	26318486
Pubmed	Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates.	AKT1 AKT2	2.03e-06	2	50	2	25136137
Pubmed	Differential function of Akt1 and Akt2 in human adipocytes.	AKT1 AKT2	2.03e-06	2	50	2	22480544
Pubmed	Knockout of Akt1/2 suppresses the metastasis of human prostate cancer cells CWR22rv1 in vitro and in vivo.	AKT1 AKT2	2.03e-06	2	50	2	33377281
Pubmed	Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization.	AKT1 AKT2	2.03e-06	2	50	2	22647600
Pubmed	Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin.	AKT1 AKT2	2.03e-06	2	50	2	9620559
Pubmed	Akt isoform-specific inhibition of MDA-MB-231 cell proliferation.	AKT1 AKT2	2.03e-06	2	50	2	20688159
Pubmed	Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium.	AKT1 AKT2	2.03e-06	2	50	2	26971877
Pubmed	Akt1 and Akt2 differently regulate muscle creatine kinase and myogenin gene transcription in insulin-induced differentiation of C2C12 myoblasts.	AKT1 AKT2	2.03e-06	2	50	2	11861503
Pubmed	Significance of Akt activation and AKT gene increases in soft tissue tumors.	AKT1 AKT2	2.03e-06	2	50	2	24321521
Pubmed	Akt regulates basic helix-loop-helix transcription factor-coactivator complex formation and activity during neuronal differentiation.	AKT1 AKT2	2.03e-06	2	50	2	12808085
Pubmed	FBXW10 promotes hepatocarcinogenesis in male patients and mice.	FBXW10B FBXW10	2.03e-06	2	50	2	31400758
Pubmed	Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes.	AKT1 AKT2	2.03e-06	2	50	2	15010337
Pubmed	Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy.	AKT1 AKT2	2.03e-06	2	50	2	36229454
Pubmed	Akt2 regulates cardiac metabolism and cardiomyocyte survival.	AKT1 AKT2	2.03e-06	2	50	2	16950770
Pubmed	Akt isoforms differentially regulate neutrophil functions.	AKT1 AKT2	2.03e-06	2	50	2	20332370
Pubmed	Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma.	AKT1 AKT2	2.03e-06	2	50	2	3037531
Pubmed	High-intensity muscle contraction-mediated increases in Akt1 and Akt2 phosphorylation do not contribute to mTORC1 activation and muscle protein synthesis.	AKT1 AKT2	2.03e-06	2	50	2	32078465
Pubmed	Akt as a target for cancer therapy: more is not always better (lessons from studies in mice).	AKT1 AKT2	2.03e-06	2	50	2	28557977
Pubmed	Redundant roles of AKT1 and AKT2 in fertility, estrous cyclicity and endometrial gland development.	AKT1 AKT2	2.03e-06	2	50	2	37053038
Pubmed	Defining Akt actions in muscle differentiation.	AKT1 AKT2	2.03e-06	2	50	2	23076793
Pubmed	Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer.	AKT1 AKT2	2.03e-06	2	50	2	19110052
Pubmed	Loss of Akt1 or Akt2 delays mammary tumor onset and suppresses tumor growth rate in MTB-IGFIR transgenic mice.	AKT1 AKT2	2.03e-06	2	50	2	23919516
Pubmed	Cutaneous human papillomaviruses down-regulate AKT1, whereas AKT2 up-regulation and activation associates with tumors.	AKT1 AKT2	2.03e-06	2	50	2	17804734
Pubmed	Roles of AKT1 and AKT2 in non-small cell lung cancer cell survival, growth, and migration.	AKT1 AKT2	2.03e-06	2	50	2	21722267
Pubmed	Lack of AKT in adipocytes causes severe lipodystrophy.	AKT1 AKT2	2.03e-06	2	50	2	27408773
Pubmed	Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation.	AKT1 AKT2	2.03e-06	2	50	2	17141631
Pubmed	PI3K/AKT Signaling in Breast Cancer Molecular Subtyping and Lymph Node Involvement.	AKT1 AKT2	2.03e-06	2	50	2	31781306
Pubmed	Opposing Actions of AKT (Protein Kinase B) Isoforms in Vascular Smooth Muscle Injury and Therapeutic Response.	AKT1 AKT2	2.03e-06	2	50	2	29025710
Pubmed	Decreased spermatogenesis, fertility, and altered Slc2A expression in Akt1-/- and Akt2-/- testes and sperm.	AKT1 AKT2	2.03e-06	2	50	2	22228739
Pubmed	Alternative AKT2 splicing produces protein lacking the hydrophobic motif regulatory region.	AKT1 AKT2	2.03e-06	2	50	2	33253205
Pubmed	Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis.	AKT1 AKT2	2.03e-06	2	50	2	16075056
Pubmed	IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival.	AKT1 AKT2	2.03e-06	2	50	2	18042802
Pubmed	Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.	FBXW10B FBXW10	2.03e-06	2	50	2	37450367
Pubmed	Akt-1 and Akt-2 Differentially Regulate the Development of Experimental Autoimmune Encephalomyelitis by Controlling Proliferation of Thymus-Derived Regulatory T Cells.	AKT1 AKT2	2.03e-06	2	50	2	30692211
Pubmed	Distinct actions of akt1 on skeletal architecture and function.	AKT1 AKT2	2.03e-06	2	50	2	24663486
Pubmed	AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.	AKT1 AKT2	2.03e-06	2	50	2	20354168
Pubmed	The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation.	AKT1 AKT2	2.03e-06	2	50	2	17914025
Pubmed	Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression.	AKT1 AKT2	2.03e-06	2	50	2	19491266
Pubmed	Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.	AKT1 AKT2	2.03e-06	2	50	2	17609365
Pubmed	Identification of functional domains in AKT responsible for distinct roles of AKT isoforms in pressure-stimulated cancer cell adhesion.	AKT1 AKT2	2.03e-06	2	50	2	17825284
Pubmed	Depletion of Akt1 and Akt2 Impairs the Repair of Radiation-Induced DNA Double Strand Breaks via Homologous Recombination.	AKT1 AKT2	2.03e-06	2	50	2	31847370
Pubmed	Unique roles of Akt1 and Akt2 in IGF-IR mediated lung tumorigenesis.	AKT1 AKT2	2.03e-06	2	50	2	26654940
Pubmed	Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions.	AKT1 AKT2	2.03e-06	2	50	2	16923802
Pubmed	AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins.	AKT1 AKT2	2.03e-06	2	50	2	28287129
Pubmed	Role of AMPK and Akt in triple negative breast cancer lung colonization.	AKT1 AKT2	2.03e-06	2	50	2	33839456
Pubmed	Akt1 and Akt2: differentiating the aktion.	AKT1 AKT2	2.03e-06	2	50	2	21432781
Pubmed	Molecular alterations in AKT and its protein activation in human lung carcinomas.	AKT1 AKT2	2.03e-06	2	50	2	22748472
Pubmed	Distinct roles of AKT isoforms in regulating β1-integrin activity, migration, and invasion in prostate cancer.	AKT1 AKT2	2.03e-06	2	50	2	22809628
Pubmed	Iris Nertschinskia ethanol extract differentially induces cytotoxicity in human breast cancer cells depending on AKT1/2 activity.	AKT1 AKT2	2.03e-06	2	50	2	23464484
Pubmed	Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner.	AKT1 AKT2	2.03e-06	2	50	2	17045205
Pubmed	Akt1 and Akt2 promote peripheral B-cell maturation and survival.	AKT1 AKT2	2.03e-06	2	50	2	20042722
Pubmed	Akt1 and Akt2 Isoforms Play Distinct Roles in Regulating the Development of Inflammation and Fibrosis Associated with Alcoholic Liver Disease.	AKT1 AKT2	2.03e-06	2	50	2	31671832
Pubmed	PKB signaling and atrogene expression in skeletal muscle of aged mice.	AKT1 AKT2	2.03e-06	2	50	2	21551011
Pubmed	Differential phosphorylation of Akt1 and Akt2 by protein kinase CK2 may account for isoform specific functions.	AKT1 AKT2	2.03e-06	2	50	2	24769357
Pubmed	Polymorphisms in the AKT1 and AKT2 genes and oesophageal squamous cell carcinoma risk in an Eastern Chinese population.	AKT1 AKT2	2.03e-06	2	50	2	26828791
Pubmed	Distinct and specific roles of AKT1 and AKT2 in androgen-sensitive and androgen-independent prostate cancer cells.	AKT1 AKT2	2.03e-06	2	50	2	23567263
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CACNA1E RANBP2 TRIM67 STXBP2 N4BP2 SYNE1 DZIP1L SPTBN1 CFAP210 TEX14 DCC	5.04e-06	1442	50	11	35575683
Pubmed	Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer.	AKT1 AKT2	6.07e-06	3	50	2	19805051
Pubmed	In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis.	AKT1 AKT2	6.07e-06	3	50	2	18757368
Pubmed	Deletion of PKBalpha/Akt1 affects thymic development.	AKT1 AKT2	6.07e-06	3	50	2	17912369
Pubmed	Differential activation of AKT isoforms by growth factors in human myotubes.	AKT1 AKT2	6.07e-06	3	50	2	37879895
Pubmed	Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2).	AKT1 AKT2	6.07e-06	3	50	2	21737686
Pubmed	Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming.	AKT1 AKT2	6.07e-06	3	50	2	27505672
Pubmed	SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes.	AKT1 AKT2	6.07e-06	3	50	2	14744864
Pubmed	Signalling specificity in the Akt pathway in breast cancer.	AKT1 AKT2	6.07e-06	3	50	2	25233414
Pubmed	Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation.	AKT1 AKT2	6.07e-06	3	50	2	21555366
Pubmed	Specific Akt Family Members Impair Stress-Mediated Transactivation of Viral Promoters and Enhance Neuronal Differentiation: Important Functions for Maintaining Latency.	AKT1 AKT2	6.07e-06	3	50	2	32796067
Pubmed	All Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear.	AKT1 AKT2	6.07e-06	3	50	2	25811375
Pubmed	Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development.	AKT1 AKT2	6.07e-06	3	50	2	20724596
Pubmed	Differential prognostic values of the three AKT isoforms in acute myeloid leukemia.	AKT1 AKT2	6.07e-06	3	50	2	38528080
Pubmed	GSK3beta is a negative regulator of platelet function and thrombosis.	AKT1 AKT2	6.07e-06	3	50	2	18218855
Pubmed	Regulatory effects of mammalian target of rapamycin-mediated signals in the generation of arsenic trioxide responses.	AKT1 AKT2	6.07e-06	3	50	2	18048359
Pubmed	Cell-Autonomous versus Systemic Akt Isoform Deletions Uncovered New Roles for Akt1 and Akt2 in Breast Cancer.	AKT1 AKT2	6.07e-06	3	50	2	32931746
Pubmed	Akt Regulates Axon Wrapping and Myelin Sheath Thickness in the PNS.	AKT1 AKT2	6.07e-06	3	50	2	27098694
Pubmed	Phosphatase and tensin homologue determine inflammatory status by differentially regulating the expression of Akt1 and Akt2 in macrophage alternative polarization of periodontitis.	AKT1 AKT2	6.07e-06	3	50	2	36217693
Pubmed	Increased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2.	AKT1 AKT2	6.07e-06	3	50	2	15987444
Pubmed	Combined PI3K/Akt and Hsp90 targeting synergistically suppresses essential functions of alloreactive T cells and increases Tregs.	AKT1 AKT2	6.07e-06	3	50	2	26265781
Pubmed	Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice.	AKT1 AKT2	6.07e-06	3	50	2	25240046
Pubmed	Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production.	AKT1 AKT2	6.07e-06	3	50	2	27238637
Pubmed	Skeletal Muscle Tissue Trib3 Links Obesity with Insulin Resistance by Autophagic Degradation of AKT2.	AKT1 AKT2	6.07e-06	3	50	2	30071535
Pubmed	MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells.	AKT1 AKT2	6.07e-06	3	50	2	19825827
Pubmed	Kinetic mechanism of AKT/PKB enzyme family.	AKT1 AKT2	6.07e-06	3	50	2	16540465
Pubmed	MicroRNAs associated with increased AKT gene number in human lung carcinoma.	AKT1 AKT2	6.07e-06	3	50	2	27189341
Pubmed	Variation in Akt protein kinases in human populations.	AKT1 AKT2	6.07e-06	3	50	2	28931550
Pubmed	AKT2 is essential to maintain podocyte viability and function during chronic kidney disease.	AKT1 AKT2	6.07e-06	3	50	2	24056770
Interaction	FBXW10B interactions	FBXW10B FBXW10 TRIM67	1.19e-08	3	47	3	int:FBXW10B
Interaction	FBXW10 interactions	FBXW10B FBXW10 TRIM67	3.34e-06	13	47	3	int:FBXW10
Interaction	AKAP13 interactions	HARS2 RANBP2 TRIM67 RNF103 ARHGEF12	7.33e-06	116	47	5	int:AKAP13
Cytoband	6q25	SYNE1 ULBP3	7.62e-05	12	50	2	6q25
Cytoband	Ensembl 112 genes in cytogenetic band chr1q25	CACNA1E RGSL1 HMCN1	8.17e-04	167	50	3	chr1q25
Cytoband	17p12	FBXW10B FBXW10	1.32e-03	49	50	2	17p12
Cytoband	1q42.13	RNF187 ITPKB	1.32e-03	49	50	2	1q42.13
Cytoband	Ensembl 112 genes in cytogenetic band chr1q42	TRIM67 RNF187 ITPKB	2.31e-03	240	50	3	chr1q42
GeneFamily	WD repeat domain containing\|F-box and WD repeat domain containing	FBXW10B FBXW10	1.98e-04	11	35	2	559
GeneFamily	WD repeat domain containing	FBXW10B FBXW10 WDR11 CFAP44	1.58e-03	262	35	4	362
ToppCell	Bronchial_Biopsy-Epithelial-Ciliated_1\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	SYNE1 DZIP1L AKAP14 CFAP210 CFAP44	2.44e-06	192	50	5	be592e661367affced9ebe80849b466e6adb3a34
ToppCell	Bronchial_Biopsy-Epithelial-Ciliated_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	SYNE1 DZIP1L AKAP14 CFAP210 CFAP44	2.50e-06	193	50	5	0b62a6ddd7c42efd9f39781971d1438501e1fa8d
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FBXW10 SYNE1 DZIP1L CFAP210 CFAP44	2.56e-06	194	50	5	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	NS-control-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SYNE1 DZIP1L AKAP14 CFAP210 CFAP44	2.69e-06	196	50	5	d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCell	NS-moderate-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SYNE1 DZIP1L AKAP14 CFAP210 CFAP44	2.76e-06	197	50	5	71fea4aa6ce96c7693fa94792d08770622873850
ToppCell	control-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SYNE1 DZIP1L AKAP14 CFAP210 CFAP44	2.76e-06	197	50	5	e453d085182364ca347cbcc9dc995c62c3353016
ToppCell	control-Epithelial-Ciliated\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SYNE1 DZIP1L AKAP14 CFAP210 CFAP44	2.76e-06	197	50	5	d4e963c1f82996371bf3d63578ee9fce8e00c5a8
ToppCell	critical-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SYNE1 DZIP1L AKAP14 CFAP210 CFAP44	2.83e-06	198	50	5	ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Ciliated\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	SYNE1 DZIP1L AKAP14 CFAP210 CFAP44	2.97e-06	200	50	5	6a2ccc71a0cbe04a542c379b28b5006de53981c3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 FRZB LAMA2 DCC	3.05e-05	159	50	4	5ca96db4281abb5f646150ccf36adc66ab201c78
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 FRZB LAMA2 DCC	3.44e-05	164	50	4	f6a961fa2002da7d9679f32af99e1314c0593ef9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 FRZB LAMA2 DCC	3.96e-05	170	50	4	876b84740e15399bfff2b9c7f0b80fd759bbdb3f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 FRZB LAMA2 DCC	3.96e-05	170	50	4	1f8738acf439d893880db7e1fdc9b3615ca00c39
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 FRZB LAMA2 DCC	4.14e-05	172	50	4	08a3fe536b1b064c5ee7779bc2b1115a5963a26b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 FRZB LAMA2 DCC	4.14e-05	172	50	4	553701349444eb366df3c11f54bb093434f153c6
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA1E TRIM67 FRZB TEX14	4.33e-05	174	50	4	c529f3674b784f872f4387ffdeb46aecb619976b
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_NK-T_mait-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CPNE2 SAMD9 SYNE1 FRZB	4.43e-05	175	50	4	cc2428150987911d0d382e8177918724aa69f85c
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_NK-T_mait\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CPNE2 SAMD9 SYNE1 FRZB	4.53e-05	176	50	4	003076f1a983409ddf31b9c19e61c1facdd72566
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RANBP2 SYNE1 IRF8 ITPKB	4.73e-05	178	50	4	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	C1orf232 DZIP1L CFAP210 CFAP44	4.94e-05	180	50	4	92fb01b91261b3103454924cde56add337b41844
ToppCell	10x5'v1-week_12-13-Myeloid_neutrophil-granulo-neutrophil-myelocyte\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	CPNE2 STXBP2 SYNE1 DZIP1L	5.16e-05	182	50	4	52eac2f892ea7f26731e0b21c578fd2665a1657a
ToppCell	NS-critical-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DZIP1L AKAP14 CFAP210 CFAP44	5.61e-05	186	50	4	76033438426d8f9c72cd6691a7baf92104c9f03d
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 FRZB LAMA2 DCC	5.73e-05	187	50	4	d591a3c216997663ab77710fed0d230ffc37e41a
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 FRZB LAMA2 DCC	5.73e-05	187	50	4	d1dc8c9a2c2cd10c640257161a75e7730ec5bb41
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 FRZB LAMA2 DCC	5.73e-05	187	50	4	ac8e092b37e042975e2ee057d3f7c6821e58e8b5
ToppCell	Epithelial-Epithelial-D_(Ciliated)\|Epithelial / shred on cell class and cell subclass (v4)	SYNE1 AKAP14 CFAP210 CFAP44	5.85e-05	188	50	4	8f30535a32968a81a304315a49c0d90a77d36948
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HMCN1 GLI3 LAMA2 DCC	5.97e-05	189	50	4	203c80030df08ae112f9ae4043709f455d87ce89
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DZIP1L AKAP14 CFAP210 CFAP44	6.35e-05	192	50	4	1b6cac8156e608061e1405e36e18d185b6fa8f6f
ToppCell	Bronchial_Brush-Epithelial-Ciliated_1\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	SYNE1 AKAP14 CFAP210 CFAP44	6.61e-05	194	50	4	b4ce60c06568123008b1081d644733cb91c28f51
ToppCell	Bronchial_Brush-Epithelial-Ciliated_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	SYNE1 AKAP14 CFAP210 CFAP44	6.61e-05	194	50	4	7a7ddccfe72a4a0dc4d1a5c809988f0069f9f1a3
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	SYNE1 SPTBN1 ARHGEF12 CFAP210	6.74e-05	195	50	4	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	SYNE1 SPTBN1 ARHGEF12 CFAP210	6.74e-05	195	50	4	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SYNE1 DZIP1L CFAP210 CFAP44	6.74e-05	195	50	4	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	critical-Epithelial-Ciliated\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DZIP1L AKAP14 CFAP210 CFAP44	6.88e-05	196	50	4	27b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	SYNE1 SPTBN1 ARHGEF12 CFAP210	6.88e-05	196	50	4	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	SYNE1 SPTBN1 ARHGEF12 CFAP210	6.88e-05	196	50	4	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	PSB-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SYNE1 DZIP1L CFAP210 CFAP44	7.01e-05	197	50	4	6865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYNE1 DZIP1L AKAP14 CFAP44	7.01e-05	197	50	4	22c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYNE1 DZIP1L CFAP210 CFAP44	7.01e-05	197	50	4	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYNE1 DZIP1L AKAP14 CFAP44	7.01e-05	197	50	4	3bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYNE1 DZIP1L AKAP14 CFAP44	7.01e-05	197	50	4	87db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCell	Control_saline\|World / Treatment groups by lineage, cell group, cell type	HMCN1 SPTBN1 FRZB VASH1	7.29e-05	199	50	4	11c9c1779caceb725ecccf3f23b7d4e6dbd1af64
ToppCell	(10)_Ciliated\|World / shred by cell type by condition	SYNE1 AKAP14 CFAP210 CFAP44	7.44e-05	200	50	4	1b6a8025bd2746b626040058c122b1be3ab2fa61
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	HMCN1 SPTBN1 VASH1 ARHGEF12	7.44e-05	200	50	4	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	(09)_Interm._secr.>cil.\|World / shred by cell type by condition	SYNE1 AKAP14 CFAP210 CFAP44	7.44e-05	200	50	4	3305e14dba12e94da42f0414fdc7a2c8caf0a183
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_activate-7\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FRZB IRF8 AKAP14	4.37e-04	132	50	3	c07842a4b514f1e950c8af303f3b6b4275906e6a
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular\|TCGA-Stomach / Sample_Type by Project: Shred V9	FBXW10B CENPE CFAP44	4.98e-04	138	50	3	93497c0a5d5e54006653b2dedc7a7041e1a613e6
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPNE2 CENPE FGB	5.87e-04	146	50	3	74009a2921359a8352afbaea8c325a3743622543
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPNE2 CENPE FGB	5.87e-04	146	50	3	cb19f2bb6832d11fe69b670df49eac096a378a9d
ToppCell	LPS-antiTNF-Endothelial-Epi-like-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FRZB CFAP44 ULBP3	6.35e-04	150	50	3	9cb3332924bd67c966873343c14445e30d3f384f
ToppCell	Control-PLT_4\|World / Disease Group and Platelet Clusters	RNF103 LEMD3 TEX14	6.85e-04	154	50	3	a2a03c5e6759c45aeeedf1e68ecb5a0112ef9a20
ToppCell	Adult-Immune-dendritic_cell-D122\|Adult / Lineage, Cell type, age group and donor	N4BP2 VASH1 IRF8	6.85e-04	154	50	3	64a4686586d08b1e9632dde917b472ac660de2d3
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-Migrating_MyoFibroblast\|E16.5-samps / Age Group, Lineage, Cell class and subclass	TRIM67 FRZB LAMA2	6.98e-04	155	50	3	1882fa5fd25f77d6e3ac47b613f6fb3c67d8e50c
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 LAMA2 DCC	7.65e-04	160	50	3	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXA7 CACNA1E IRF8	7.65e-04	160	50	3	e9e52532131cdc3fb01e81cfc046e3f670cc8e75
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 LAMA2 DCC	7.65e-04	160	50	3	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRIM67 FAM240C CENPE	7.79e-04	161	50	3	2165897924c790fec43502283f1df221c56c1e9f
ToppCell	Adult-Immune-dendritic_cell\|Adult / Lineage, Cell type, age group and donor	VASH1 IRF8 SEPTIN12	8.36e-04	165	50	3	073f52698dac1fe4edd7410865f81b30e1c7196a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 LAMA2 TEX14	8.36e-04	165	50	3	e2aebb2fe197151e019371b8960f76f0c2386f08
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 LAMA2 TEX14	8.36e-04	165	50	3	b087771499aeb31cc4a338d2d0a9392a4ec1ac45
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 LAMA2 TEX14	8.36e-04	165	50	3	d8f8b088fd28a6b9dbd6b51bcaee42000e963321
ToppCell	droplet-Spleen-nan-24m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPNE2 SYNE1 HNMT	8.36e-04	165	50	3	3cdb921f5b9facf04f81995d5641ac14ef3dbb6f
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage_3\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	GLI3 VXN LAMA2	8.66e-04	167	50	3	5c82d801e3b7d7c6c967a73b94b2ee2a8da1fd6e
ToppCell	Control-Myeloid-MoAM1,_IL1R2\|Myeloid / Condition, Lineage and Cell class	SAMD9 SYNE1 LAMA2	8.66e-04	167	50	3	6e5140527437193f441ca96893b9a00d346614f3
ToppCell	Sigmoid-Macrophage-Macrophage\|Macrophage / Region, Cell class and subclass	GRIPAP1 VASH1 IRF8	8.81e-04	168	50	3	bb16e135b6ae0d66615420b61edd6f62f2a3233c
ToppCell	facs-Heart-LV-18m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GLI3 FRZB LAMA2	8.96e-04	169	50	3	849a8f8509c58d65462a09c84d58b6ecdc8934f5
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RNF103 DZIP1L CFAP210	8.96e-04	169	50	3	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	facs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXA7 FBXW10 RGSL1	9.12e-04	170	50	3	d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCell	droplet-Spleen-nan-3m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNE1 TEX14 HNMT	9.12e-04	170	50	3	dbd6c9c7be824a1ff1b31af791064127cafbd194
ToppCell	droplet-Lung-nan-18m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXA7 CACNA1E IRF8	9.12e-04	170	50	3	749144a1a869a6bf9acdd227184319083367dc3f
ToppCell	droplet-Lung-nan-18m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXA7 CACNA1E IRF8	9.12e-04	170	50	3	25d60a62e8f99c31ab64fe6a0c07ccca3df1a7ee
ToppCell	droplet-Lung-18m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HOXA7 CACNA1E IRF8	9.43e-04	172	50	3	422d311bba2dd5d8bece4e96ee8c86e78086b62d
ToppCell	Ciliated_cells-B-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	AKAP14 CFAP210 CFAP44	9.43e-04	172	50	3	187ae91148d293537afc77e10da2b64302322224
ToppCell	droplet-Lung-18m-Hematologic-myeloid-plasmacytoid_dendritic_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HOXA7 CACNA1E IRF8	9.43e-04	172	50	3	1abb6fbb28c8aff384540493d0f70eeacaa751f4
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXA7 FBXW10 ARHGEF12	9.59e-04	173	50	3	0a0cd40bb5f61431fe34758626c8a63ec610a8a5
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBXW10 AKAP14 CFAP44	9.59e-04	173	50	3	a7cc63bb3ab41feb9e4072700d44dbbbc62c47c6
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	N4BP2 HNMT USP47	9.59e-04	173	50	3	c31076c725f4cd912c56903592a2d9356ae59f54
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	N4BP2 HNMT USP47	9.59e-04	173	50	3	a4ed191cfdf6588b7f3672995bf0a4fe9e4b8df6
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBXW10 AKAP14 CFAP44	9.59e-04	173	50	3	e3e3a67a5a93ef4475224a256d45ae24526383cc
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 FRZB LAMA2	9.91e-04	175	50	3	1b4cefae400bf756d09ece32d3f5c0bd4c6ad73f
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MBOAT1 SYNE1 FRZB	9.91e-04	175	50	3	12f5fd83c7710fc0c77406f765d9cbd133433b8b
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRZB VXN DCC	9.91e-04	175	50	3	d67c77eee979ad029e7545f383326f0ff77c6e5f
ToppCell	COVID-mDC1-\|COVID / Condition, Cell_class and T cell subcluster	HOXA7 VASH1 IRF8	9.91e-04	175	50	3	83a95d6fc2ddf3ec53f05825bbc982fb8d2ccd15
ToppCell	COVID-mDC1\|COVID / Condition, Cell_class and T cell subcluster	HOXA7 VASH1 IRF8	9.91e-04	175	50	3	b9280444016e21c28131a61df65cc5c56d402412
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRZB VXN DCC	9.91e-04	175	50	3	1d1cdbf3221b03e24eae38afd57cbd6736b37a53
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HOXA7 MBOAT1 CENPE	9.91e-04	175	50	3	3e56695a9db97cb1d3503425c48eb79bbf99213e
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 FRZB LAMA2	1.01e-03	176	50	3	e9152defb4fd41267fb33c42c01fd0c683280783
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E FBXW10 IRF8	1.01e-03	176	50	3	0f056597bc9e53176ce8670924ac925c801964b5
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 FRZB LAMA2	1.01e-03	176	50	3	a4d269075aa0efc46fa251b379f334e50c69391d
ToppCell	facs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GLI3 FRZB LAMA2	1.01e-03	176	50	3	fee4e0f32aaf77294040c7af6c1f503571750d43
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 FRZB LAMA2	1.01e-03	176	50	3	cc6f65a7d2c622841c9d1ab3755586039d4ccc4d
ToppCell	facs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GLI3 FRZB LAMA2	1.01e-03	176	50	3	f25251abd4ef9fb077a978f9f9f658af58e4e0d2
ToppCell	facs-Trachea-24m-Hematologic-lymphocytic-B_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1E STXBP2 IRF8	1.01e-03	176	50	3	318dc722b95e269002fb01a0feb91c0c8539e150
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	HMCN1 FRZB LAMA2	1.01e-03	176	50	3	510f9a14dc1c151d24d079e0cc004cdf4f86336c
ToppCell	facs-Trachea-24m-Hematologic-lymphocytic-B_cell-B_cell_of_the_trachea\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1E STXBP2 IRF8	1.01e-03	176	50	3	f6891006d816309edabe75b2abf60675f2958e55
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E FBXW10 IRF8	1.01e-03	176	50	3	d04be5acf0be46adc3d2055f6f21358c02792817
ToppCell	droplet-Lung-21m-Epithelial-airway_epithelial-lung_ciliated_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DZIP1L AKAP14 CFAP44	1.02e-03	177	50	3	d947ba38db1772fc5fdcdc211f7511c4aa699dee
ToppCell	droplet-Lung-21m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DZIP1L AKAP14 CFAP44	1.02e-03	177	50	3	d5640f0097878f0dac671e51dc51310278bb2682
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FRZB ARHGEF12 TEX14	1.04e-03	178	50	3	e5e4742e35c3d90f82b830d77bdbdc45828c7deb
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CENPE FRZB VASH1	1.04e-03	178	50	3	9fc5688cf705a74398d24e10e0aab4758612e72b
Disease	meningitis	CACNA1E ITPKB	1.41e-04	11	48	2	MONDO_0021108
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	LEMD3 SYNE1	1.69e-04	12	48	2	DOID:11726 (implicated_via_orthology)
Disease	chenodeoxycholate measurement	HMCN1 DCC	2.68e-04	15	48	2	EFO_0010471
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	DZIP1L AKT1	3.06e-04	16	48	2	DOID:0110861 (implicated_via_orthology)
Disease	muscular dystrophy (is_implicated_in)	SYNE1 LAMA2	3.47e-04	17	48	2	DOID:9884 (is_implicated_in)
Disease	prostate adenocarcinoma (is_implicated_in)	AKT1 AKT2	4.83e-04	20	48	2	DOID:2526 (is_implicated_in)
Disease	Adenocarcinoma of large intestine	AKT1 AKT2 DCC	5.19e-04	96	48	3	C1319315
Disease	Nasopharyngeal carcinoma	SYNE1 AKT2	5.86e-04	22	48	2	C2931822
Disease	malignant astrocytoma (is_marker_for)	AKT1 AKT2	6.41e-04	23	48	2	DOID:3069 (is_marker_for)
Disease	aggressive behavior	SAMD9 MBOAT1	7.59e-04	25	48	2	EFO_0003015
Disease	Kallmann Syndrome	WDR11 DCC	8.21e-04	26	48	2	C0162809
Disease	Colorectal cancer	AKT1 DCC	8.86e-04	27	48	2	cv:C0346629
Disease	COLORECTAL CANCER	AKT1 DCC	8.86e-04	27	48	2	114500
Disease	Neoplasm of the large intestine	AKT1 DCC	8.86e-04	27	48	2	cv:C0009404
Disease	Neoplasm of uncertain or unknown behavior of ovary	AKT1 AKT2	1.02e-03	29	48	2	C0496920
Disease	bipolar disorder (is_implicated_in)	SYNE1 AKT1	1.02e-03	29	48	2	DOID:3312 (is_implicated_in)
Disease	Ovarian Carcinoma	AKT1 AKT2	1.09e-03	30	48	2	C0029925
Disease	type 2 diabetes mellitus (is_marker_for)	FRZB FGB AKT2	1.42e-03	136	48	3	DOID:9352 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
MSDVAIVKEGWLHKR	AKT1	1	P31749
MNEVSVIKEGWLHKR	AKT2	1	P31751
KWMTHGEFTVEKGLK	AKAP14	66	Q86UN6
DDGKWMLVHRTEVIK	CPNE2	186	Q96FN4
HEKNKMEVKGREWKR	CACNA1E	1336	Q15878
VDDGKSMRVKHPKWK	FBXW10	356	Q5XX13
KWGFLTHKLAEMRVK	C1orf232	166	A0A0U1RR37
AWEKEKHELGLMKLK	CFAP44	1006	Q96MT7
WERKVEIAEMSLKGH	CCDC113	341	Q9H0I3
TKRKMIHEGPLVWKV	ARHGEF12	1016	Q9NZN5
KERGVGDIKILWHTM	RANBP2	2951	P49792
PHDRKKMKKVWDRAV	LEMD3	706	Q9Y2U8
VDDGKSMRVKHPKWK	FBXW10B	356	O95170
EWKRKVKELHEEHMA	DZIP1L	336	Q8IYY4
VIKWKKDGIHLALGM	DCC	71	P43146
GTKWMEHVKLERLKQ	GLI3	771	P10071
LIEMEDWKGDKVKAH	FGB	341	P02675
RMLEKKELQKWDFIH	HNMT	126	P50135
EEKSMFRIPWKHAGK	IRF8	31	Q02556
QWHKIKIMRSKQEGI	LAMA2	2846	P24043
EVKNAMRKLWHGKII	OR4C11	291	Q6IEV9
WMKDGHPLIKAKGVE	HMCN1	2326	Q96RW7
FHGKWKDKFKAERIM	SERPINA2	216	P20848
EGKHIHMKLLEVNWK	MBOAT1	211	Q6ZNC8
DSGGIKMFWEKKIEH	FAM240C	21	A0A1B0GVR7
EKWMLEEKVKHLEVS	GRIPAP1	721	Q4V328
LVGKIHWEKMVKKVS	RNF103	131	O00237
HWEKMVKKVSRFGIR	RNF103	136	O00237
EMALKWITKGEKSRH	CENPE	176	Q02224
RRMKWKKEHKDEGPT	HOXA7	181	P31268
MHLVIWKVREDAKTK	REXO1	1206	Q8N1G1
LQGHVMKSIEEKWFK	RGSL1	736	A5PLK6
AWKDVRHEMVVKKGL	HARS2	246	P49590
DDGKVHLKWKMEVKE	TEX14	926	Q8IWB6
AAAVWKGHVMDRRKK	RNF187	156	Q5TA31
WEKDIIKMLGLEKAH	MRPL30	81	Q8TCC3
MVKKTGDWKKHVETN	SYNE1	911	Q8NF91
LKWLKKEHLVDMGIT	SAMD9	46	Q5K651
LLFIHDKKEQAKVWM	ITPKB	881	P27987
VKEKLTGLHKMWEVL	SPTBN1	1351	Q01082
VMKADQIFWEHEKEK	CFAP210	406	Q0VFZ6
VVHAGARRMKEKWEK	ULBP3	161	Q9BZM4
GKEPWNIKRHEMVAK	ZNF100	91	Q8IYN0
KVTKEREHKLKMVWD	TRIM67	411	Q6ZTA4
VKRWDMKLRHLGLSK	FRZB	286	Q92765
SVKKDGEWKVLIMDH	STXBP2	21	Q15833
RKTKWGIIEVENMAH	SEPTIN12	266	Q8IYM1
GEGHKWLMVHVDKRI	USP47	1046	Q96K76
GILRKMWTRHKKKSE	VXN	181	Q8TAG6
VLEKHKADVVKVKWA	WDR11	56	Q9BZH6
RMWKHVAKIHPDGEK	VASH1	76	Q7L8A9
AKVIHEKWKESVMER	N4BP2	1416	Q86UW6