Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP-dependent protein disaggregase activity

HSPA1A HSPA1B HSPA8

4.61e-0661243GO:0140545
GeneOntologyMolecularFunctionC3HC4-type RING finger domain binding

HSPA1A HSPA1B HSPA8

4.61e-0661243GO:0055131
GeneOntologyMolecularFunctionATP-dependent protein folding chaperone

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

4.71e-06401245GO:0140662
GeneOntologyMolecularFunctionNF-kappaB binding

CPNE1 BCL10 HSPA1A HSPA1B

7.15e-05361244GO:0051059
GeneOntologyMolecularFunctionprotein folding chaperone

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

9.13e-05731245GO:0044183
GeneOntologyMolecularFunctionprotein-containing complex destabilizing activity

HSPA1A HSPA1B HSPA8

1.01e-04151243GO:0140776
GeneOntologyMolecularFunctiondenatured protein binding

HSPA1A HSPA1B

1.14e-0431242GO:0031249
GeneOntologyMolecularFunctiondeath receptor agonist activity

HSPA1A HSPA1B

3.78e-0451242GO:0038177
GeneOntologyMolecularFunctioncytoskeleton-nuclear membrane anchor activity

SYNE1 SYNE2

3.78e-0451242GO:0140444
GeneOntologyMolecularFunctionadenosine receptor binding

GRM5 HSPA8

1.05e-0381242GO:0031685
GeneOntologyMolecularFunctionunfolded protein binding

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

1.14e-031261245GO:0051082
GeneOntologyBiologicalProcessprotein refolding

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

8.79e-07301235GO:0042026
GeneOntologyBiologicalProcesschaperone cofactor-dependent protein refolding

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

1.95e-06351235GO:0051085
GeneOntologyBiologicalProcesscellular heat acclimation

HSPA1A HSPA1B HSPA6

4.09e-0661233GO:0070370
GeneOntologyBiologicalProcess'de novo' post-translational protein folding

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

4.39e-06411235GO:0051084
GeneOntologyBiologicalProcessheat acclimation

HSPA1A HSPA1B HSPA6

7.12e-0671233GO:0010286
GeneOntologyBiologicalProcess'de novo' protein folding

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

7.83e-06461235GO:0006458
GeneOntologyBiologicalProcesspositive regulation of tumor necrosis factor-mediated signaling pathway

CPNE1 HSPA1A HSPA1B

7.18e-05141233GO:1903265
GeneOntologyBiologicalProcessformin-nucleated actin cable organization

SPIRE2 FMN2

1.05e-0431232GO:0110009
GeneOntologyBiologicalProcessformin-nucleated actin cable assembly

SPIRE2 FMN2

1.05e-0431232GO:0070649
GeneOntologyBiologicalProcesschaperone-mediated protein folding

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

1.17e-04801235GO:0061077
GeneOntologyCellularComponentCOP9 signalosome

HSPA1A HSPA1B HSPA1L HSPA6

7.45e-05381244GO:0008180
GeneOntologyCellularComponentsite of double-strand break

RNF169 SMARCA5 SMCHD1 WDR70 DGCR8

3.41e-041011245GO:0035861
GeneOntologyCellularComponentdendrite

USP50 DIP2B URI1 SYNE1 FAT3 SRGAP2 GRM5 LRIT3 ITPKA CACNG3 IFT52 SORCS2 RTN4RL2 HSPA8

5.73e-0485812414GO:0030425
GeneOntologyCellularComponentdendritic tree

USP50 DIP2B URI1 SYNE1 FAT3 SRGAP2 GRM5 LRIT3 ITPKA CACNG3 IFT52 SORCS2 RTN4RL2 HSPA8

5.86e-0486012414GO:0097447
GeneOntologyCellularComponentdendritic spine

USP50 SYNE1 SRGAP2 GRM5 ITPKA SORCS2 HSPA8

6.10e-042421247GO:0043197
GeneOntologyCellularComponentneuron spine

USP50 SYNE1 SRGAP2 GRM5 ITPKA SORCS2 HSPA8

6.88e-042471247GO:0044309
GeneOntologyCellularComponentcytoplasmic vesicle membrane

SPIRE2 ANPEP RAB8B APOB ITGAL AQP4 CACNG3 IGF2R TBC1D4 STX5 SLCO4C1 CADPS SORCS2 SLC9A7 FMN2 CPNE1 HSPA8 ECE2

7.00e-04130712418GO:0030659
GeneOntologyCellularComponentvesicle membrane

SPIRE2 ANPEP RAB8B APOB ITGAL AQP4 CACNG3 IGF2R TBC1D4 STX5 SLCO4C1 CADPS SORCS2 SLC9A7 FMN2 CPNE1 HSPA8 ECE2

8.20e-04132512418GO:0012506
GeneOntologyCellularComponentficolin-1-rich granule lumen

SRP14 HSPA1A HSPA1B HSPA6 HSPA8

8.69e-041241245GO:1904813
GeneOntologyCellularComponentsomatodendritic compartment

USP50 DIP2B URI1 SYNE1 FAT3 APOB SRGAP2 GRM5 PTGER3 LRIT3 ITPKA CACNG3 IFT52 SCN1B SORCS2 RTN4RL2 HSPA8

9.41e-04122812417GO:0036477
GeneOntologyCellularComponentsecretory granule

DOCK2 ANPEP SRP14 ITGAL NIT2 IGF2R SLCO4C1 BRCA2 CADPS CPNE1 PYGB HSPA1A HSPA1B HSPA6 HSPA8

9.91e-04101412415GO:0030141
GeneOntologyCellularComponentsite of DNA damage

RNF169 SMARCA5 SMCHD1 WDR70 DGCR8

1.36e-031371245GO:0090734
GeneOntologyCellularComponentblood microparticle

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

1.69e-031441245GO:0072562
GeneOntologyCellularComponentzona pellucida receptor complex

HSPA1B HSPA1L

1.85e-03111242GO:0002199
GeneOntologyCellularComponentnuclear membrane protein complex

SYNE1 SYNE2

1.85e-03111242GO:0106083
GeneOntologyCellularComponentnuclear membrane microtubule tethering complex

SYNE1 SYNE2

1.85e-03111242GO:0106094
GeneOntologyCellularComponentmicrotubule organizing center attachment site

SYNE1 SYNE2

1.85e-03111242GO:0034992
GeneOntologyCellularComponentmeiotic nuclear membrane microtubule tethering complex

SYNE1 SYNE2

1.85e-03111242GO:0034993
GeneOntologyCellularComponentperikaryon

DIP2B LRIT3 SCN1B SORCS2 RTN4RL2 HSPA8

2.16e-032231246GO:0043204
DomainHSP70

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

4.70e-08161235PF00012
DomainHSP70_2

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

6.63e-08171235PS00329
DomainHSP70_1

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

6.63e-08171235PS00297
DomainHSP70_3

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

6.63e-08171235PS01036
DomainHsp_70_fam

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

9.13e-08181235IPR013126
Domain-

HSPA1A HSPA1L HSPA6 HSPA8

8.51e-071212342.60.34.10
DomainHSP70_peptide-bd

HSPA1A HSPA1L HSPA6 HSPA8

8.51e-07121234IPR029047
Domain-

HSPA1A HSPA1L HSPA6 HSPA8

1.22e-061312341.20.1270.10
DomainHeat_shock_70_CS

HSPA1A HSPA1L HSPA6 HSPA8

1.22e-06131234IPR018181
DomainHSP70_C

HSPA1A HSPA1L HSPA6 HSPA8

1.22e-06131234IPR029048
DomainKASH

SYNE1 SYNE2

2.56e-0441232IPR012315
DomainKASH

SYNE1 SYNE2

2.56e-0441232PS51049
DomainKASH

SYNE1 SYNE2

2.56e-0441232SM01249
DomainKASH

SYNE1 SYNE2

2.56e-0441232PF10541
PathwayREACTOME_ATTENUATION_PHASE

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

1.03e-0628945M27254
PathwayREACTOME_ATTENUATION_PHASE

HSPA1A HSPA1B HSPA1L HSPA8

1.27e-0613944MM14952
PathwayREACTOME_HSF1_DEPENDENT_TRANSACTIVATION

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

4.99e-0638945M27255
PathwayREACTOME_HSF1_DEPENDENT_TRANSACTIVATION

HSPA1A HSPA1B HSPA1L HSPA8

1.49e-0523944MM14953
PathwayREACTOME_NEUTROPHIL_DEGRANULATION

DOCK2 ANPEP SRP14 ITGAL NIT2 IGF2R SLCO4C1 CPNE1 PYGB HSPA1A HSPA1B HSPA6 HSPA8

1.63e-054789413M27620
PathwayREACTOME_HSF1_ACTIVATION

HSPA1A HSPA1B HSPA1L HSPA6

5.08e-0531944M27252
PathwayWP_PARKINUBIQUITIN_PROTEASOMAL_SYSTEM_PATHWAY

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

1.09e-0471945M39690
PathwayREACTOME_NEUTROPHIL_DEGRANULATION

DOCK2 ANPEP SRP14 ITGAL NIT2 IGF2R SLCO4C1 CPNE1 PYGB HSPA1A HSPA1B HSPA8

1.45e-045119412MM15330
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

2.16e-0482945M27250
PathwayWP_MEASLES_VIRUS_INFECTION

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8 CDK6

2.93e-04136946M42547
PathwayKEGG_ANTIGEN_PROCESSING_AND_PRESENTATION

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

3.00e-0488945M16004
PathwayREACTOME_HSP90_CHAPERONE_CYCLE_FOR_STEROID_HORMONE_RECEPTORS_SHR_IN_THE_PRESENCE_OF_LIGAND

HSPA1A HSPA1B HSPA1L HSPA8

3.93e-0452944MM14949
PathwayREACTOME_HSP90_CHAPERONE_CYCLE_FOR_STEROID_HORMONE_RECEPTORS_SHR_IN_THE_PRESENCE_OF_LIGAND

HSPA1A HSPA1B HSPA1L HSPA8

5.59e-0457944M27251
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

5.66e-04101945M27253
Pubmed

Association analysis of heat shock protein 70 gene polymorphisms in schizophrenia.

HSPA1A HSPA1B HSPA1L HSPA8

1.64e-104126418299791
Pubmed

HDJC9, a novel human type C DnaJ/HSP40 member interacts with and cochaperones HSP70 through the J domain.

HSPA1A HSPA1B HSPA1L HSPA8

8.19e-105126417182002
Pubmed

Genetic aspects of the hsp70 multigene family in vertebrates.

HSPA1A HSPA1B HSPA1L HSPA8

2.45e-09612647988674
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

DIP2B SPIRE2 DOCK11 MYO9A SRGAP2 MAST2 TBC1D4 STX5 RABGAP1L SYNE2 EXO1 FMN2 FAM53B DCLK2 PEAK1 WDR62 ARAP2

1.57e-088611261736931259
Pubmed

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities.

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

1.84e-0823126521231916
Pubmed

Reciprocal regulation of human immunodeficiency virus-1 gene expression and replication by heat shock proteins 40 and 70.

HSPA1A HSPA1B HSPA6 HSPA8

2.04e-089126421763498
Pubmed

Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription.

POLR2B HSPA1A HSPA1B HSPA6 HSPA8

2.32e-0824126510617616
Pubmed

Specific incorporation of heat shock protein 70 family members into primate lentiviral virions.

HSPA1A HSPA1B HSPA6 HSPA8

3.39e-0810126411932435
Pubmed

gp120 neurotoxicity fails to induce heat shock defenses, while the over expression of hsp70 protects against gp120.

HSPA1A HSPA1B HSPA6 HSPA8

3.39e-0810126412832005
Pubmed

Human immunodeficiency virus type 1 interaction with the membrane of CD4+ cells induces the synthesis and nuclear translocation of 70K heat shock protein.

HSPA1A HSPA1B HSPA6 HSPA8

3.39e-081012647906708
Pubmed

Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation.

HSPA1A HSPA1B HSPA6 HSPA8

3.39e-0810126423921388
Pubmed

Analysis of heat shock protein 70 gene polymorphisms Mexican patients with idiopathic pulmonary fibrosis.

HSPA1A HSPA1B HSPA1L

4.64e-083126326496868
Pubmed

Genetic polymorphisms of HSP70 in age-related cataract.

HSPA1A HSPA1B HSPA1L

4.64e-083126323666708
Pubmed

Stress-induced localization of HSPA6 (HSP70B') and HSPA1A (HSP70-1) proteins to centrioles in human neuronal cells.

HSPA1A HSPA1B HSPA6

4.64e-083126324061851
Pubmed

Interacting contribution of the five polymorphisms in three genes of Hsp70 family to essential hypertension in Uygur ethnicity.

HSPA1A HSPA1B HSPA1L

4.64e-083126319085089
Pubmed

Heat shock protein 70 gene polymorphisms in Mexican patients with spondyloarthropathies.

HSPA1A HSPA1B HSPA1L

4.64e-083126311779758
Pubmed

The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients.

HSPA1A HSPA1B HSPA1L

4.64e-083126319439993
Pubmed

Is preeclampsia associated with higher frequency of HSP70 gene polymorphisms?

HSPA1A HSPA1B HSPA1L

4.64e-083126316202503
Pubmed

Heat-shock protein-70 genes and response to antidepressants in major depression.

HSPA1A HSPA1B HSPA1L

4.64e-083126317428599
Pubmed

Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia.

HSPA1A HSPA1B HSPA1L

4.64e-083126315963589
Pubmed

Heat shock protein 70 gene polymorphisms in sudden sensorineural hearing loss.

HSPA1A HSPA1B HSPA1L

4.64e-083126322922572
Pubmed

Heat shock protein 70 gene polymorphisms in Han nationality of China with chronic obstructive pulmonary diseases.

HSPA1A HSPA1B HSPA1L

4.64e-083126315165109
Pubmed

Electrophoretic and immunocytochemical analysis of Hsp72 and Hsp73 expression in heat-stressed mouse testis and epididymis.

HSPA1A HSPA1B HSPA8

4.64e-083126323352621
Pubmed

A prospective evaluation of the heat shock protein 70 gene polymorphisms and the risk of stroke.

HSPA1A HSPA1B HSPA1L

4.64e-083126312008944
Pubmed

Stored of Hsp72/Hsp73 in germinal vesicle-stage mouse oocytes.

HSPA1A HSPA1B HSPA8

4.64e-083126315129916
Pubmed

Association of hsp70-2 and hsp-hom gene polymorphisms with risk of acute high-altitude illness in a Chinese population.

HSPA1A HSPA1B HSPA1L

4.64e-083126316333988
Pubmed

Heat shock protein 70 gene polymorphisms are associated with paranoid schizophrenia in the Polish population.

HSPA1A HSPA1B HSPA1L

4.64e-083126323893339
Pubmed

Interactive association of heat shock protein 70 genes variants with natural longevity in Xinjiang Hetian Uygur ethnicity.

HSPA1A HSPA1B HSPA1L

4.64e-083126319840767
Pubmed

Chromosomal location of human genes encoding major heat-shock protein HSP70.

HSPA1A HSPA1B HSPA1L

4.64e-08312633470951
Pubmed

Heat-shock protein gene polymorphisms and the risk of nephropathy in patients with Type 2 diabetes.

HSPA1A HSPA1B HSPA1L

4.64e-083126318518860
Pubmed

Genetic interaction of Hsp70 family genes polymorphisms with high-altitude pulmonary edema among Chinese railway constructors at altitudes exceeding 4000 meters.

HSPA1A HSPA1B HSPA1L

4.64e-083126319351530
Pubmed

Localization of a human heat-shock HSP 70 gene sequence to chromosome 6 and detection of two other loci by somatic-cell hybrid and restriction fragment length polymorphism analysis.

HSPA1A HSPA1B HSPA1L

4.64e-08312632880793
Pubmed

HLA complex-linked heat shock protein genes and childhood acute lymphoblastic leukemia susceptibility.

HSPA1A HSPA1B HSPA1L

4.64e-083126320012387
Pubmed

Analysis of the heat shock protein 70 (HSP70) genetic variants in nonsegmental vitiligo patients.

HSPA1A HSPA1B HSPA1L

4.64e-083126336345598
Pubmed

Functional analysis of HSPA1A and HSPA8 in parturition.

HSPA1A HSPA1B HSPA8

4.64e-083126328025138
Pubmed

Structure and expression of the three MHC-linked HSP70 genes.

HSPA1A HSPA1B HSPA1L

4.64e-08312631700760
Pubmed

Heat shock protein 70 gene polymorphism in Japanese patients with multiple sclerosis.

HSPA1A HSPA1B HSPA1L

4.64e-083126311696222
Pubmed

The relationship between three heat shock protein 70 gene polymorphisms and susceptibility to lung cancer.

HSPA1A HSPA1B HSPA1L

4.64e-083126320704535
Pubmed

Anti-inflammatory heat shock protein 70 genes are positively associated with human survival.

HSPA1A HSPA1B HSPA1L

4.64e-083126320388090
Pubmed

Human major histocompatibility complex contains genes for the major heat shock protein HSP70.

HSPA1A HSPA1B HSPA1L

4.64e-08312632538825
Pubmed

Analysis of heat-shock protein 70 gene polymorphisms and the risk of Parkinson's disease.

HSPA1A HSPA1B HSPA1L

4.64e-083126314605873
Pubmed

Genomic structure of the spermatid-specific hsp70 homolog gene located in the class III region of the major histocompatibility complex of mouse and man.

HSPA1A HSPA1B HSPA1L

4.64e-08312639685725
Pubmed

Effects of polymorphisms of heat shock protein 70 gene on ischemic stroke, and interaction with smoking in China.

HSPA1A HSPA1B HSPA1L

4.64e-083126317582394
Pubmed

Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study.

HSPA1A HSPA1B HSPA1L

4.64e-083126328182740
Pubmed

HIV-1 viral protein R (Vpr) and its interactions with host cell.

HSPA1A HSPA1B HSPA6 HSPA8

7.95e-0812126419275587
Pubmed

A CASPR1-ATP1B3 protein interaction modulates plasma membrane localization of Na+/K+-ATPase in brain microvascular endothelial cells.

HSPA1A HSPA1B HSPA1L HSPA8

1.14e-0713126430792309
Pubmed

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.

HSPA1A HSPA1B HSPA1L HSPA8

1.14e-0713126427477512
Pubmed

Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations.

HSPA1A HSPA1B HSPA1L

1.85e-074126318813331
Pubmed

[Effect of HSP70 gene polymorphism on genetic susceptibility of pneumoconiosis of coal worker].

HSPA1A HSPA1B HSPA1L

1.85e-074126320568452
Pubmed

Delayed temporal increase of hepatic Hsp70 in ApoE knockout mice after prenatal arsenic exposure.

HSPA1A HSPA1B HSPA8

1.85e-074126322956628
Pubmed

Upregulation of the constitutively expressed HSC70 by KLF4.

HSPA1A HSPA1B HSPA8

1.85e-074126318379898
Pubmed

Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus.

HSPA1A HSPA1B HSPA1L

1.85e-074126320498198
Pubmed

Heat-shock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral preintegration complex.

HSPA1A HSPA1B HSPA6 HSPA8

2.17e-0715126410964507
Pubmed

Clathrin facilitates the morphogenesis of retrovirus particles.

HSPA1A HSPA1B HSPA6 HSPA8

2.89e-0716126421738476
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

SYNE1 ZC3H13 MAST2 SYNE2 HSPA1A HSPA1L HSPA6 HSPA8

4.40e-07187126826460568
Pubmed

A DnaJ protein, apobec-1-binding protein-2, modulates apolipoprotein B mRNA editing.

HSPA1A HSPA1B HSPA8

4.62e-075126311584023
Pubmed

Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration.

HSPA1A HSPA1B HSPA8

4.62e-075126316906134
Pubmed

A susceptibility gene for alveolar lung tumors in the mouse maps between Hsp70.3 and G7 within the H2 complex.

HSPA1A HSPA1B HSPA1L

4.62e-07512637806281
Pubmed

Small kinetochore associated protein (SKAP) promotes UV-induced cell apoptosis through negatively regulating pre-mRNA processing factor 19 (Prp19).

HSPA1A HSPA6 HSPA8

4.62e-075126324718257
Pubmed

Polymorphisms in TNF and HSP-70 show a significant association with gastric cancer and duodenal ulcer.

HSPA1A HSPA1B HSPA1L

4.62e-075126319626584
Pubmed

A screen for deubiquitinating enzymes involved in the G₂/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability.

USP50 HSPA1A HSPA8

4.62e-075126320930503
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

DOCK11 MYO19 ZC3H13 MUC19 CPT1B DARS2 OR2K2 ADRA1A TBC1D4 R3HCC1L TRPM3 TBC1D14 FMN2 HSPA8

4.96e-077361261429676528
Pubmed

Phosphorylation and binding partner analysis of the TSC1-TSC2 complex.

HSPA1A HSPA1B HSPA8

9.21e-076126315963462
Pubmed

New microsatellite size variants as markers for a cross-over hotspot in the C4-H-2D region.

HSPA1A HSPA1B HSPA1L

9.21e-07612638199408
Pubmed

BAG-1 modulates the chaperone activity of Hsp70/Hsc70.

HSPA1A HSPA1B HSPA8

9.21e-07612639305631
Pubmed

RING finger protein RNF207, a novel regulator of cardiac excitation.

HSPA1A HSPA1B HSPA8

9.21e-076126325281747
Pubmed

Three Hsp70 genes are located in the C4-H-2D region: possible candidates for the Orch-1 locus.

HSPA1A HSPA1B HSPA1L

9.21e-07612638449501
Pubmed

Heat shock factor 2 is activated during mouse heart development.

HSPA1A HSPA1B HSPA8

9.21e-076126311032181
Pubmed

RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.

URI1 POLR2B HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

1.21e-06148126735676246
Pubmed

Molecular analysis of the major MHC recombinational hot spot located within the G7c gene of the murine class III region that is involved in disease susceptibility.

HSPA1A HSPA1B HSPA1L

1.61e-06712639551980
Pubmed

Control of mRNA decay by heat shock-ubiquitin-proteasome pathway.

HSPA1A HSPA1B HSPA8

1.61e-067126310205060
Pubmed

Messenger RNA expression of heat shock proteins (HSPs) during ocular development.

HSPA1B HSPA1L HSPA8

1.61e-06712638974842
Pubmed

Prothymosin-α enhances phosphatase and tensin homolog expression and binds with tripartite motif-containing protein 21 to regulate Kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2 signaling in human bladder cancer.

HSPA1A HSPA1L HSPA6 HSPA8

1.65e-0624126430719818
Pubmed

Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex.

SMCHD1 STX5 HSPA1A HSPA8

1.65e-0624126435543156
Pubmed

Function and regulation of heat shock factor 2 during mouse embryogenesis.

HSPA1A HSPA1B HSPA8

2.57e-06812639122205
Pubmed

The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.

DIP2B RAB8B POLR2B SRP14 HSPA1A HSPA1B HSPA6 HSPA8

2.60e-06237126829564676
Pubmed

A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein.

URI1 HSPA1A HSPA1L HSPA6 HSPA8

2.91e-0661126519875381
Pubmed

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.

HSPA1A HSPA1L HSPA6 HSPA8

3.14e-0628126438492217
Pubmed

WWP2 is an E3 ubiquitin ligase for PTEN.

HSPA1A HSPA1L HSPA6 HSPA8

3.64e-0629126421532586
Pubmed

Chromosomal localization of five murine HSP70 gene family members: Hsp70-1, Hsp70-2, Hsp70-3, Hsc70t, and Grp78.

HSPA1A HSPA1B HSPA1L

3.84e-06912638486356
Pubmed

Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.

HSPA1A HSPA1B HSPA1L HSPA6

5.46e-0632126418850735
Pubmed

Proteomic analysis reveals novel binding partners of MIP-T3 in human cells.

HSPA1A HSPA1L HSPA6 HSPA8

7.00e-0634126420391533
Pubmed

ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation.

HSPA1A HSPA1B HSPA8

7.50e-0611126327708256
Pubmed

Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.

HSPA1A HSPA1B HSPA8

7.50e-0611126324318877
Pubmed

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.

URI1 SRP14 NADSYN1 SYNE2 HSPA1B HSPA1L HSPA6 HSPA8 CDK6

7.50e-06363126925036637
Pubmed

Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase.

HSPA1A HSPA1B HSPA6 HSPA8

7.88e-0635126419287380
Pubmed

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.

HSPA1A HSPA1B HSPA8

9.97e-0612126312150907
Pubmed

The ubiquitin-specific protease USP15 promotes RIG-I-mediated antiviral signaling by deubiquitylating TRIM25.

HSPA1A HSPA1B HSPA1L

9.97e-0612126324399297
Pubmed

P1 and cosmid clones define the organization of 280 kb of the mouse H-2 complex containing the Cps-1 and Hsp70 loci.

HSPA1A HSPA1B HSPA1L

9.97e-061212637993390
Pubmed

Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication.

CCDC14 SPAG5 WDR62

1.29e-0513126326297806
Pubmed

Exercise induces hepatosplanchnic release of heat shock protein 72 in humans.

HSPA1A HSPA1B

1.30e-052126212411538
Pubmed

Molecular cloning and analysis of DNA complementary to three mouse Mr = 68,000 heat shock protein mRNAs.

HSPA1A HSPA1B

1.30e-05212622868009
Pubmed

Up-regulation of inducible heat shock protein-70 expression in multiple sclerosis patients.

HSPA1A HSPA1B

1.30e-052126224328534
Pubmed

In vitro transcription of a human hsp 70 heat shock gene by extracts prepared from heat-shocked and non-heat-shocked human cells.

HSPA1A HSPA1B

1.30e-05212623786141
Pubmed

Processing of U14 small nucleolar RNA from three different introns of the mouse 70-kDa-cognate-heat-shock-protein pre-messenger RNA.

HSPA1B HSPA8

1.30e-05212627813466
Pubmed

Characterization of the binding between a 70-kDa heat shock protein, HspA1A, and phosphoinositides.

HSPA1A HSPA1B

1.30e-052126226923070
Pubmed

Soluble heat shock protein 70 members in patients undergoing allogeneic hematopoietic cell transplantation.

HSPA1A HSPA6

1.30e-052126227020764
Pubmed

Surface expression of HSP72 by LPS-stimulated neutrophils facilitates gammadeltaT cell-mediated killing.

HSPA1A HSPA1B

1.30e-052126216482515
Pubmed

Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.

SYNE1 SYNE2

1.30e-052126211792814
Pubmed

Effect of hyaluronan oligosaccharides on the expression of heat shock protein 72.

HSPA1A HSPA1B

1.30e-052126211864979
InteractionCCNI2 interactions

HSPA1B HSPA1L HSPA6 HSPA8

1.68e-0791244int:CCNI2
InteractionCCDC117 interactions

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

4.82e-07261245int:CCDC117
InteractionLRRC28 interactions

HSPA1B HSPA1L HSPA6 HSPA8

9.35e-07131244int:LRRC28
InteractionYWHAH interactions

DIP2B SPIRE2 DOCK11 MYO9A ZC3H13 SRGAP2 MAST2 CWC22 TBC1D4 STX5 RABGAP1L SYNE2 EXO1 FMN2 FAM53B DCLK2 PEAK1 HSPA1A WDR62 ARAP2

1.27e-05110212420int:YWHAH
InteractionIRF2BPL interactions

RNF169 RC3H1 NADK2 HSPA1A HSPA8

1.84e-05531245int:IRF2BPL
InteractionYWHAG interactions

SPIRE2 DOCK11 MYO9A ZC3H13 RC3H1 SRGAP2 MAST2 CWC22 TBC1D4 RABGAP1L SYNE2 EXO1 FMN2 FAM53B DCLK2 PEAK1 HSPA1A HSPA8 ZMYM3 WDR62 ARAP2

2.33e-05124812421int:YWHAG
InteractionCCDC142 interactions

HSPA1B HSPA1L HSPA8

2.64e-05101243int:CCDC142
InteractionGAN interactions

SYNE1 ZC3H13 MAST2 SYNE2 HSPA1A HSPA1L HSPA6 HSPA8 ZMYM3

2.72e-052531249int:GAN
InteractionDNAJB2 interactions

SRP14 HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

4.00e-051021246int:DNAJB2
InteractionFBXL4 interactions

MYO19 POLR2B CRYBG1 HSPA1A HSPA1B HSPA8

4.96e-051061246int:FBXL4
InteractionUSP50 interactions

USP50 IGF2R HSPA1A HSPA8

6.17e-05351244int:USP50
InteractionCFAP52 interactions

BRCA2 HSPA1A HSPA8

6.22e-05131243int:CFAP52
InteractionFAM83F interactions

HSPA1A HSPA1B HSPA6 HSPA8

6.91e-05361244int:FAM83F
InteractionMETTL21A interactions

HSPA1A HSPA1B HSPA1L HSPA8

6.91e-05361244int:METTL21A
InteractionDENND2D interactions

CWC22 HSPA1B HSPA1L HSPA8

6.91e-05361244int:DENND2D
InteractionDCLRE1B interactions

SPAG5 BRCA2 HSPA1A HSPA8

7.71e-05371244int:DCLRE1B
InteractionVILL interactions

TBC1D14 HSPA6 HSPA8

7.88e-05141243int:VILL
InteractionSFN interactions

SPIRE2 DOCK11 MYO9A SRGAP2 MAST2 TBC1D4 RABGAP1L EXO1 FMN2 FAM53B PEAK1 HSPA8 WDR62 ARAP2

9.26e-0569212414int:SFN
InteractionCYP2W1 interactions

HSPA1B HSPA1L HSPA8

9.80e-05151243int:CYP2W1
InteractionZUP1 interactions

POLR2B DARS2 KRT80 HELZ2 HSPA1A HSPA1L HSPA8

1.02e-041741247int:ZUP1
InteractionPRODH interactions

HSPA1L HSPA6 HSPA8

1.20e-04161243int:PRODH
InteractionVASH1 interactions

HSPA1L HSPA6 HSPA8

1.20e-04161243int:VASH1
InteractionC3orf38 interactions

HSPA1A HSPA6 HSPA8

1.45e-04171243int:C3orf38
InteractionYWHAB interactions

SPIRE2 URI1 DOCK11 MYO9A RC3H1 SRGAP2 MAST2 TBC1D4 EXO1 FAM53B DCLK2 PEAK1 HSPA1A HSPA1B HSPA8 WDR62 ARAP2

1.59e-04101412417int:YWHAB
InteractionRNF123 interactions

DOCK11 MYO19 ZC3H13 MUC19 CPT1B DARS2 OR2K2 ADRA1A TBC1D4 R3HCC1L TRPM3 TBC1D14 FMN2 HSPA1L HSPA8

1.65e-0482412415int:RNF123
InteractionARFGAP1 interactions

DIP2B APOB STX5 RABGAP1L HSPA1A HSPA8

1.89e-041351246int:ARFGAP1
InteractionTRIM38 interactions

HSPA1A HSPA1B HSPA1L HSPA8

1.98e-04471244int:TRIM38
InteractionDHDH interactions

MYO19 ZNF185 HSPA1B HSPA8

1.98e-04471244int:DHDH
InteractionTRMU interactions

FAT3 ZNF185 DARS2 HSPA1L HSPA8

2.01e-04871245int:TRMU
InteractionFRMD8P1 interactions

HSPA6 HSPA8

2.24e-0441242int:FRMD8P1
GeneFamilyHeat shock 70kDa proteins

HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

1.71e-0817915583
GeneFamilySpectrin repeat containing nuclear envelope family

SYNE1 SYNE2

1.49e-0449121252
GeneFamilyMaestro heat like repeat containing

MROH2A MROH1

1.34e-0311912636
CoexpressionAIZARANI_LIVER_C12_NK_NKT_CELLS_4

ITGAL HSPA1A HSPA1B HSPA6 HSPA8

3.82e-06491265M39116
CoexpressionGSE11818_WT_VS_DICER_KO_TREG_UP

FAT3 GRM5 ITPKA SCN1B CRYBG1 CATSPERB DLEC1

6.99e-061461267M412
CoexpressionDEN_INTERACT_WITH_LCA5

HSPA1A HSPA1B HSPA1L HSPA8

7.01e-06261264M1380
CoexpressionYAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP

TNFRSF9 ZC3H13 SRGAP2 PTGER3 BRWD3 HSPA1A HSPA1B

1.22e-051591267MM777
CoexpressionKRISHNAN_FURIN_TARGETS_UP

HSPA1A HSPA1B HSPA8

1.27e-05101263MM1243
CoexpressionBENPORATH_EED_TARGETS

URI1 DOCK11 PTGER3 DARS2 ITPKA EVA1C ADRA1A HOXD9 SPOCK3 SORCS2 CRYBG1 DCLK2 RTN4RL2 HSPA1A HSPA1B HSPA1L HSPA6

1.31e-05105912617M7617
CoexpressionNOJIMA_SFRP2_TARGETS_UP

TNFRSF9 HSPA1A HSPA1B HSPA6

1.65e-05321264M14772
CoexpressionAtlasdev gonad_e13.5_F_SupCellPrec_Sry_k-means-cluster#3_top-relative-expression-ranked_1000

DOCK2 ANPEP LHPP SLC9A7 PYGB FAM53B GREB1 HSPA8 ARAP2 CDK6

4.20e-0628111910gudmap_dev gonad_e13.5_F_SupCellPrec_Sry_k3_1000
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#1_top-relative-expression-ranked_1000

DOCK2 ZNF845 ANPEP LHPP PYGB PEAK1 HSPA8 CDK6

4.43e-061661198gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k1_1000
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_MedNas_2500_K1

ZNF845 SMARCA5 ZC3H13 FAT3 FAM98B CPT1B ZNF691 KRT80 SPAG5 BRCA2 CADPS SYNE2 KCNJ16 EXO1 SLC9A7 GREB1 GPR176 WDR62

2.49e-05106011918facebase_RNAseq_e10.5_Emin_MedNas_2500_K1
CoexpressionAtlasNK cells, NK.b2m-.Sp, NK1.1+ TCRb-, Spleen, avg-3

DOCK2 TNFRSF9 ITGAL RABGAP1L SLC9A7 CRYBG1 FAM53B PEAK1 HSPA8 ARAP2

7.00e-0539011910GSM538291_500
ToppCellSevere-CD4+_T_activated|Severe / Disease group and Cell class

USP50 SMCHD1 HELZ2 HSPA1A HSPA1B HSPA6 HSPA8

7.37e-071771267a08f170f1143fcdd7d0842a54d9b807a4548f8b7
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMARCA5 SYNE1 SMCHD1 TAX1BP1 SYNE2 HSPA8 ARAP2

7.66e-07178126701dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellCOVID-19-kidney-Epi_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

MYO9A GRM5 SYNE2 KCNJ16 FMN2 GPR176 NR1H4

7.66e-071781267544379f5a6145429762258d426b876bb36c112f5
ToppCellCOVID-19-kidney-T-cells-2|COVID-19 / Disease (COVID-19 only), tissue and cell type

DOCK2 TNFRSF9 ITGAL HSPA1A HSPA1B HSPA6 HSPA8

1.10e-06188126715484c05cb496cd98ed3f79a6134c5cec8f09a4d
ToppCellCOVID-19-kidney-T-cells-2|kidney / Disease (COVID-19 only), tissue and cell type

DOCK2 TNFRSF9 ITGAL HSPA1A HSPA1B HSPA6 HSPA8

1.23e-061911267698e6a28276704f8baa082d028db2345b973c4bc
ToppCellCOVID-19-kidney-CNT|COVID-19 / Disease (COVID-19 only), tissue and cell type

FRAS1 PTGER3 HOXD9 TRPM3 KCNJ16 CRYBG1 NR1H4

1.27e-061921267760c6b9628de9693034b00c5025c5c4df94bb2e8
ToppCellLA-08._Macrophage|World / Chamber and Cluster_Paper

DOCK2 DOCK11 SRGAP2 BRCA2 TBC1D14 SCN9A ARAP2

1.36e-061941267c1805572bcc11b1cd29083329d7b5911489fb758
ToppCell368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

SYNE1 TBC1D14 SCN9A HSPA1A HSPA1B PLEKHO1 HSPA6

1.36e-06194126758046894446cb250814252a23f60fdd59c114d77
ToppCellsystemic_lupus_erythematosus-flare|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SMARCA5 URI1 SYNE1 SMCHD1 TAX1BP1 SYNE2 HSPA8

1.56e-0619812674c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCellP28-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CPT1B ADRA1A FMN2 DLEC1 DGCR8 MYBPC2

5.12e-06154126644d4d99b08216c0901e3bc32743fa0a8b85b5149
ToppCell5'-Adult-SmallIntestine-Hematopoietic-T_cells-CD8_Tmem|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CLDND1 ITGAL HSPA1A HSPA6 HSPA8 ARAP2

8.15e-061671266d80b64322d16d98c82a52724809740b9de208f39
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

FRAS1 GRM5 TRPM3 SYNE2 KCNJ16 NR1H4

8.43e-061681266a086c306be430adf0632ba53e98cd8014d2de330
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

SYNE1 SMCHD1 APOB SYNE2 CRYBG1 ARAP2

9.32e-0617112662e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell367C-Myeloid-Dendritic-cDC_activated|367C / Donor, Lineage, Cell class and subclass (all cells)

USP50 TNFRSF9 TBC1D4 PLEKHO1 ARAP2 MYBPC2

9.96e-06173126694f99f7e7813d6e53e0bedf97087400b1bf00129
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF169 DOCK11 SYNE1 ITGAL KRT80 SYNE2

1.06e-051751266cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK11 MYO9A SYNE1 FAT3 GRM5 TBC1D4

1.10e-051761266327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TNFRSF9 URI1 CLDND1 TBC1D4 SYNE2 HSPA8

1.21e-051791266593fc323b28304a57ae162f64b0890b893fff446
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TNFRSF9 URI1 CLDND1 TBC1D4 SYNE2 HSPA8

1.21e-051791266708fc0b8ffcb5fac43c52541acb6671fe1cfbb0d
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK11 ADRA1A TRPM3 SPOCK3 SCN9A ALPK3

1.29e-051811266af92b8b7f455210dab502ef6964f3a0162180759
ToppCellCOVID-19-kidney-Mito-rich_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

DOCK2 SMCHD1 ITGAL HSPA1A HSPA1B HSPA6

1.29e-0518112668448c2ad560cfd48bfe9dc1dd3a64373e6a622dd
ToppCellNS-critical-d_07-13-Epithelial-Ionocyte|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FAT3 PTGER3 TBC1D4 SPOCK3 SCN9A DCLK2

1.37e-051831266ba43bca2b45be1008eebd3f033cecb061fb3a966
ToppCellCOVID-19-kidney-PCT-S1|COVID-19 / Disease (COVID-19 only), tissue and cell type

FRAS1 SLCO4C1 TRPM3 SYNE2 KCNJ16 NR1H4

1.37e-0518312666878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCellCOVID-19_Mild-gd_T|COVID-19_Mild / Disease condition and Cell class

SYNE1 ITGAL IGF2R SYNE2 FAM53B ARAP2

1.37e-051831266f593a89b0aa8fffdfa403769916facfd30358521
ToppCellnormal-na-Lymphocytic_T-CytoT_GZMK+-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

TNFRSF9 SYNE1 SMCHD1 CLDND1 SYNE2 ARAP2

1.37e-05183126679defd22b3194dad16db55b9bdd220c09c1e6b90
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 MROH2A FAT3 APOB TRPM3 SCN9A

1.41e-0518412662cbed6462fea2622871bb7e49b0df3d984239281
ToppCellcritical-Epithelial-Ionocyte|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

FAT3 PTGER3 TBC1D4 SPOCK3 SCN9A DCLK2

1.41e-05184126658d36577eff814d46d72f031f3533d71549e3d6e
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 MROH2A FAT3 APOB TRPM3 SCN9A

1.41e-051841266ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 MROH2A FAT3 APOB TRPM3 SCN9A

1.41e-0518412662b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell10x5'-blood-Lymphocytic_T_CD4-Tregs|blood / Manually curated celltypes from each tissue

TNFRSF9 SMCHD1 CLDND1 TBC1D4 SYNE2 HSPA8

1.41e-05184126622c15ce30171c687ab564f4383ae74d38b759272
ToppCellCOVID-19_Severe-gd_T|COVID-19_Severe / Disease condition and Cell class

SYNE1 SH3BP2 ITGAL IGF2R SYNE2 FAM53B

1.41e-051841266791f1bcb954aadc63d4117c400537d036f68734d
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TNFRSF9 ANPEP IGF2R TBC1D4 R3HCC1L CDK6

1.55e-0518712664527d6426f2c4397e47f12439a13a8c14fd2aab2
ToppCellControl-T_cells|Control / group, cell type (main and fine annotations)

DOCK2 SMCHD1 ITGAL RABGAP1L SYNE2 CRYBG1

1.55e-051871266f4e8e0eba58da89b56587667555a5d4754e108c7
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FRAS1 MYO9A AQP4 TRPM3 SYNE2 SORCS2

1.55e-05187126658d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCellCOVID-19-kidney|COVID-19 / Disease (COVID-19 only), tissue and cell type

FRAS1 PTGER3 TRPM3 SYNE2 KCNJ16 NR1H4

1.55e-051871266d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCellhuman_hepatoblastoma-NK.T_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

DOCK2 TNFRSF9 DOCK11 ITGAL CRYBG1 ARAP2

1.60e-05188126671b7599e7e1d63cc0c8518c0501533755951d58f
ToppCellCOVID-19-kidney-CD-PC|COVID-19 / Disease (COVID-19 only), tissue and cell type

FRAS1 PTGER3 TRPM3 KCNJ16 CRYBG1 NR1H4

1.60e-0518812668f9996c3f3b27efaaae8960a66af77412de9c7ef
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK11 MYO9A FAT3 GRM5 TBC1D4 SYNE2

1.65e-051891266904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK11 SPOCK3 SCN9A GREB1 AGBL1 ECE2

1.70e-05190126626843ec1d19ac85a50990705353b802745d33e4d
ToppCellCOVID-19-T_cells|COVID-19 / group, cell type (main and fine annotations)

DOCK2 SMCHD1 ITGAL RABGAP1L SYNE2 ARAP2

1.75e-0519112667f64add931b64b8d35836fa6bee9ebab593844d3
ToppCellRV-08._Macrophage|World / Chamber and Cluster_Paper

DOCK2 DOCK11 SRGAP2 BRCA2 TBC1D14 SCN9A

1.80e-051921266a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCellLV-08._Macrophage|LV / Chamber and Cluster_Paper

DOCK2 DOCK11 SRGAP2 TBC1D14 SCN9A ARAP2

1.80e-0519212667be12d580aaf2f2f1562203fcad3a44639b8c5a6
ToppCellRV-08._Macrophage|RV / Chamber and Cluster_Paper

DOCK2 DOCK11 SRGAP2 BRCA2 TBC1D14 SCN9A

1.85e-05193126612bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK11 MYO9A SYNE1 GRM5 TBC1D4 SYNE2

1.85e-0519312660f2167eef8203a5659c8c72e4e77646003d64797
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

FRAS1 KDM4C SYNE1 SMCHD1 SYNE2 ARAP2

1.85e-0519312669337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell3'_v3-blood-Lymphocytic_T_CD4-Tregs|blood / Manually curated celltypes from each tissue

TNFRSF9 SMCHD1 CLDND1 TBC1D4 SYNE2 HSPA8

1.85e-0519312662ffe44edf2b02d11a7c10513692eb697a10f911e
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FRAS1 HOXD9 TRPM3 CRYBG1 HSPA1A CDK6

1.85e-051931266d994b2f2707877288f88cab7cd6002ef91962c50
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FRAS1 MYO9A PTGER3 SLCO4C1 TRPM3 KCNJ16

1.91e-05194126693c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK11 MYO9A GRM5 TBC1D4 SLCO4C1 SYNE2

1.91e-0519412668ddcaaf24cee6e30d5be52c0cbf778cfba309c53
ToppCellCOVID-19-Lymphoid-Tregs|Lymphoid / Condition, Lineage and Cell class

TNFRSF9 SMCHD1 CLDND1 TBC1D4 SYNE2 HSPA1A

1.96e-0519512669ad844d9d5aac39d133ae8ab9c4839300f08064c
ToppCellLA-08._Macrophage|LA / Chamber and Cluster_Paper

DOCK2 SRGAP2 BRCA2 TBC1D14 SCN9A ARAP2

1.96e-0519512665e1d5bdb8874091f5a2b1d0a8cc9008165718a97
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-F_2|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SYNE1 SMCHD1 CLDND1 SYNE2 HSPA1A HSPA8

2.02e-051961266ea8eceacc5d5e1a22b77c31e7c45985dc7bb15de
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYNE1 ITGAL TBC1D4 SYNE2 CRYBG1 HSPA8

2.02e-051961266e4c76e7ad68455e51fe93ce588bcec9383f8654b
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

ANPEP HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

2.02e-051961266d79a84aa25ba70483ae899cd5b52ba0bbffdcd7b
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FRAS1 MYO9A PTGER3 SLCO4C1 KCNJ16 NR1H4

2.02e-0519612666ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

FRAS1 KDM4C SYNE1 SMCHD1 SYNE2 ARAP2

2.08e-05197126657ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellCV-Severe-0|Severe / Virus stimulation, Condition and Cluster

TNFRSF9 CLDND1 STX5 RABGAP1L TAX1BP1 ARAP2

2.08e-051971266d13fc20b31ab6d9117437fba319c72f3a552858f
ToppCellBronchus_Control_(B.)-Epithelial-TX-AT1|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

FAT3 PTGER3 AQP4 TBC1D4 SCN9A DCLK2

2.08e-051971266f7ef62d78336812573148f8bfce401877ec4e29c
ToppCell343B-Lymphocytic-NK_cells-NK_cell_A|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TNFRSF9 RAB8B HSPA1A HSPA1B HSPA6 HSPA8

2.14e-051981266294a48ef6c0b89c7be948452cea79d23d3901e75
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FAT3 SPAG5 BRCA2 TRPM3 WDR62 CDK6

2.14e-0519812667225a6194c52b01c581e58d3cda107c4af96dc4f
ToppCellTransverse-T_cell-Th1|T_cell / Region, Cell class and subclass

BCL10 HSPA1A HSPA1B HSPA1L HSPA6 HSPA8

2.20e-0519912669271d9d36ffe1c169049d4340258f366916adfaf
ToppCellCOVID_vent-Lymphocytic-ILC|COVID_vent / Disease condition, Lineage, Cell class and subclass

SYNE1 ITGAL IGF2R SLCO4C1 SYNE2 ARAP2

2.20e-051991266e3ff7fa1b1de1aaf6b46cdf49afa95bad457728a
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_CTL|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK2 TNFRSF9 ITGAL HSPA1A HSPA1B HSPA8

2.20e-05199126654b64f01e7a73a88bd92b6d4e73cccde60396b2d
ToppCellCOVID_vent-Lymphocytic-ILC-NK_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

SYNE1 ITGAL IGF2R SLCO4C1 SYNE2 ARAP2

2.20e-0519912665f914962e2572b0c6372465b81b7496fa663d93c
ToppCellLPS_anti-TNF-Endothelial-Endothelial-FOXM1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

CCDC14 SPAG5 BRCA2 SYNE2 EXO1 WDR62

2.20e-05199126698575fcce726589e93fbb4df1aab03e57cb56076
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SMCHD1 SCN1B SYNE2 SCN9A HELZ2 PLEKHO1

2.26e-05200126689821a264e872ed53e08e9d3609d5cc5c314503e
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-Treg|COVID-19_Mild / Disease, condition lineage and cell class

TNFRSF9 SMCHD1 CLDND1 TBC1D4 SYNE2 HSPA8

2.26e-052001266c6ae15f7deba26008af5b647855675003bb2ebcd
ToppCellmild-NK|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SYNE1 ITGAL IGF2R SLCO4C1 SYNE2 ARAP2

2.26e-052001266a11fb1d7e124c352eb73fea0e0ec0fed577c97f7
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated|COVID-19_Mild / Disease, condition lineage and cell class

SYNE1 ITGAL IGF2R SYNE2 PEAK1 ARAP2

2.26e-0520012662281debd86e5d92e8fe0397aec9ef670800f7471
ToppCellThalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Rora-Excitatory_Neuron.Slc17a6.Rora.Cbln2_(Neuron.Slc17a6.Rora.Cbln2)|Thalamus / BrainAtlas - Mouse McCarroll V32

MROH2A PPP1R3A HOXD9 CEACAM16

3.92e-056712645202166895fd109ad0d7584fc35c74814a59ce2b
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

GRM5 CACNG3 SPOCK3 FMN2 AGBL1

6.38e-051481265d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCellAdult-Immune-enucleated_erythrocyte-D175|Adult / Lineage, Cell type, age group and donor

ZFP28 SPOCK3 HSPA1A HSPA1B HSPA8

7.24e-051521265530d5427d8617dcb223d807b73abee0ef89285f3
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4/8-lo-Trm_Tgd|lymph-node_spleen / Manually curated celltypes from each tissue

PTGER3 SLCO4C1 RTN4RL2 HSPA1A HSPA6

7.70e-05154126551ffb3fa0250bd31be764ed048728aa064056e16
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Batf3|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FRAS1 PTGER3 ITPKA KCNJ16 RTN4RL2

8.44e-051571265921805932f7974d37aed547861d555b07f30aba6
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

FAT3 GRM5 CADPS SPOCK3 AGBL1

8.96e-0515912655335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ANPEP ZFP28 CCDC168 FMN2 AGBL1

8.96e-051591265fd7db2f7328cfefdc3ada2af91006d5a91d137e1
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ANPEP ZFP28 CCDC168 FMN2 AGBL1

8.96e-051591265aaf449c768d6fbb0a1bb47746ff3bdb7f9eb8914
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ANPEP ZFP28 CCDC168 FMN2 AGBL1

8.96e-0515912658bbdef1e927f3130b578d7d7c5ff38bbe06fab63
ToppCelldroplet-Lung-nan-3m-Myeloid-Proliferating_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANPEP PTGER3 SPAG5 R3HCC1L EXO1

9.22e-0516012658a7a73b0ee1877fe02d47f745d36ae2858b529e1
ToppCell367C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

DLEC1 HSPA1A HSPA1B HSPA6

9.51e-05841264fedccab997a8ca298b97240e1db1683cdf56140b
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_4|356C / Donor, Lineage, Cell class and subclass (all cells)

NIM1K ALPK3 SLC9A7 ZMYM3 WDR62

9.78e-0516212657d43d59531cbefe3ac94953b7faf7156b2a31441
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC14 DOCK2 MYO9A SCN1B KCNJ16

1.01e-0416312658dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCellP07-Endothelial-lymphatic_endothelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MROH2A TBC1D4 HOXD9 SCN1B FAM53B

1.01e-0416312655cbab3d03bb1af9391ecad635d6eea1dd42c1337
ToppCellP07-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MROH2A TBC1D4 HOXD9 SCN1B FAM53B

1.01e-041631265322ba94c3ec1e1859c2e2195ecb3f7dab8d190f6
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC14 DOCK2 MYO9A SCN1B KCNJ16

1.01e-041631265fd243ca223079033be480a24817a399f281fa4d4
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MROH2A TBC1D4 HOXD9 SCN1B GPR176

1.04e-0416412654cfc9f92e49f86d3639e018b35b6a60dc62f494a
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MROH2A TBC1D4 HOXD9 SCN1B GPR176

1.04e-0416412657a8e5ef52a8fd2877d59ef0696af8a7af90bbed6
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MROH2A TBC1D4 HOXD9 SCN1B GPR176

1.04e-0416412655e5bd81414ea2d64f73cdef19a0a78c17bec8c18
ToppCellPND10-Endothelial-Endothelial_lymphatic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MROH2A TBC1D4 HOXD9 SCN1B GPR176

1.04e-041641265f13b8d9b7f42193f333d9a77571a1dde6bbb48d8
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)-DC2_L.1.2.1.3|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

R3HCC1L SCN9A ZNF816 HSPA1A HSPA6

1.07e-04165126576abebe80e5f8bf44825bb619ae86fcb6f66ffeb
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_6|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TNFRSF9 SMCHD1 CLDND1 TBC1D4 SYNE2

1.07e-041651265dbe231d00843cae917efd1abea6079ace3b45cdf
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_6|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TNFRSF9 SMCHD1 CLDND1 TBC1D4 SYNE2

1.07e-0416512659ccce713d4122054bf4bef4a7126d90cf9141b84
ToppCellControl-Myeloid-MoAM1,_IL1R2|Control / Condition, Lineage and Cell class

SRGAP2 CPT1B SLCO4C1 HELZ2 PLEKHO1

1.13e-041671265ab6029ba037b6a499da8758864c44e174cde5587
ToppCellControl-Myeloid-MoAM1,_IL1R2|Myeloid / Condition, Lineage and Cell class

SYNE1 CPT1B SLCO4C1 HELZ2 PLEKHO1

1.13e-0416712656e5140527437193f441ca96893b9a00d346614f3
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

TNFRSF9 COL6A6 MROH2A ITGAL

1.14e-0488126452d4e572e6800eaa073ef62adaf4e42882ce1eed
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

TNFRSF9 COL6A6 MROH2A ITGAL

1.14e-04881264eadf8f0fb1181c504942c48d55d309ca4e5f6485
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)--|Entopeduncular / BrainAtlas - Mouse McCarroll V32

TNFRSF9 COL6A6 MROH2A ITGAL

1.14e-0488126472b789cbccce675f37e0553f63df93643af12b4e
ToppCellNS-critical-d_16-33-Epithelial-Ionocyte|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FAT3 MUC19 PTGER3 SCN9A DCLK2

1.16e-0416812656a233045638cb83dab64789b996b7598c325001e
ToppCell5'-Adult-SmallIntestine-Hematopoietic-T_cells-ILC3|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RAB8B PTGER3 HSPA1A HSPA6 HSPA8

1.19e-041691265d4a0bd792bddfa34332d7dc432ce253f50d98c6f
ToppCellMyeloid-Myeloid-D_(Mast_cell)|Myeloid / shred on cell class and cell subclass (v4)

SYNE1 CPT1B PTGER3 TBC1D4 SCN1B

1.26e-0417112655f1aafc4c55a9c6c3153430186a8a351425a3cb9
ToppCell5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EECs|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTS13 TRPM3 CADPS ALPK3 CATSPERB

1.26e-041711265dd37e1693a5cfc42e40992d504f92048a8038b52
ComputationalProtein folding.

URI1 HSPA1L HSPA6 HSPA8

5.05e-0529774MODULE_355
Drug2,4,4'-trichlorobiphenyl

DIP2B TNFRSF9 DOCK11 MYO19 SMCHD1 FAT3 SRGAP2 GRM5 PTGER3 BRWD3 ITPKA PPP1R3A OR2K2 TBC1D4 BRCA2 SPOCK3 SYNE2 HELZ2 EXO1 SLC9A7 CPNE1 FAM53B GREB1 CDK6

6.38e-07141112524ctd:C081766
Drug2,4,5,2',5'-pentachlorobiphenyl

DIP2B TNFRSF9 DOCK11 MYO19 SMCHD1 FAT3 SRGAP2 GRM5 PTGER3 BRWD3 ITPKA PPP1R3A OR2K2 TBC1D4 BRCA2 SPOCK3 SYNE2 HELZ2 EXO1 SLC9A7 CPNE1 FAM53B GREB1 CDK6

9.27e-07144112524ctd:C009828
Diseasegraft-versus-host disease (biomarker_via_orthology)

HSPA1A HSPA1B HSPA8

7.03e-0751233DOID:0081267 (biomarker_via_orthology)
DiseaseMajor depression, single episode

HSPA1A HSPA1B HSPA1L

5.83e-0691233C0024517
Diseaseserum metabolite measurement

KDM4C RAB8B LHPP APOB ADRA1A IGF2R MROH1 SPOCK3 RABGAP1L SYNE2 KCNJ16 DGCR8 AGBL1 HSPA8

4.12e-0594512314EFO_0005653
DiseaseMajor Depressive Disorder

ANPEP LHPP GRM5 ADRA1A HSPA1A HSPA1B HSPA1L

7.44e-052431237C1269683
DiseaseAutosomal dominant Emery-Dreifuss muscular dystrophy

SYNE1 SYNE2

1.03e-0441232cv:CN293514
Diseasetriglyceride measurement, intermediate density lipoprotein measurement

APOB IGF2R BRCA2 SYNE2 CPNE1

1.04e-041111235EFO_0004530, EFO_0008595
DiseaseUnipolar Depression

ANPEP LHPP GRM5 ADRA1A HSPA1A HSPA1B HSPA1L

1.11e-042591237C0041696
DiseaseAutosomal Recessive Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

1.71e-0451232C1450051
Diseasemedulloblastoma (is_marker_for)

KDM4C CDK6

1.71e-0451232DOID:0050902 (is_marker_for)
DiseaseAutosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)

SYNE1 SYNE2

1.71e-0451232C0410190
DiseaseEmery-Dreifuss muscular dystrophy

SYNE1 SYNE2

2.56e-0461232cv:C0410189
DiseaseMuscular Dystrophy, Emery-Dreifuss

SYNE1 SYNE2

2.56e-0461232C0410189
DiseaseMeniere's disease (is_implicated_in)

AQP4 HSPA1A

2.56e-0461232DOID:9849 (is_implicated_in)
DiseaseVertigo

GRM5 ITPKA CADPS SPOCK3 PEAK1

2.99e-041391235HP_0002321
Diseaseretinal detachment

FAT3 GRM5

3.57e-0471232EFO_0005773
DiseaseX-Linked Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

3.57e-0471232C0751337
Diseaseretinal detachment, retinal break

FRAS1 FAT3 GRM5

4.20e-04351233EFO_0005773, EFO_0010698
DiseaseDrug Allergy

PTGER3 HSPA1A HSPA1L

4.20e-04351233C0013182
Diseasefamilial hyperlipidemia (is_implicated_in)

APOB HSPA1B

4.75e-0481232DOID:1168 (is_implicated_in)
Diseasedihydroorotate measurement

LHPP HSPA8

6.09e-0491232EFO_0800647
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN1B SCN9A

6.09e-0491232C3502809
Diseasehigh grade glioma (is_implicated_in)

NADSYN1 BRCA2 CDK6

7.21e-04421233DOID:3070 (is_implicated_in)
Diseasehuman papilloma virus infection, oral cavity cancer

LHPP TBC1D4 HSPA1A

7.21e-04421233EFO_0001668, EFO_0005570
Diseasecardiovascular system disease (is_marker_for)

APOB HSPA1A

7.59e-04101232DOID:1287 (is_marker_for)
DiseaseChildhood Medulloblastoma

KDM4C BRCA2 CDK6

7.72e-04431233C0278510
DiseaseMelanotic medulloblastoma

KDM4C BRCA2 CDK6

7.72e-04431233C1275668
DiseaseMedullomyoblastoma

KDM4C BRCA2 CDK6

7.72e-04431233C0205833
DiseaseDesmoplastic Medulloblastoma

KDM4C BRCA2 CDK6

7.72e-04431233C0751291
Diseasetriglycerides in large LDL measurement

APOB IGF2R SYNE2

7.72e-04431233EFO_0022319
DiseaseAdult Medulloblastoma

KDM4C BRCA2 CDK6

7.72e-04431233C0278876
Diseasecardiac troponin I measurement

ELFN2 ALPK3 CRYBG1 GREB1 ARAP2

8.74e-041761235EFO_0010071
DiseaseEmery-Dreifuss muscular dystrophy (implicated_via_orthology)

SYNE1 SYNE2

1.11e-03121232DOID:11726 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1B SCN9A

1.11e-03121232DOID:0060170 (implicated_via_orthology)
DiseaseSudden infant death syndrome

AQP4 SCN1B

1.11e-03121232C0038644
DiseaseKawasaki disease (is_implicated_in)

HSPA1A HSPA1L

1.11e-03121232DOID:13378 (is_implicated_in)
DiseaseMedulloblastoma

KDM4C BRCA2 CDK6

1.20e-03501233C0025149
Diseasewhite matter microstructure measurement

DIP2B SPIRE2 APOB SRGAP2 MAST2 CATSPERB AGBL1

1.28e-033901237EFO_0005674
Diseaseamyotrophic lateral sclerosis (biomarker_via_orthology)

AQP4 IGF2R

1.30e-03131232DOID:332 (biomarker_via_orthology)
DiseaseInfantile Severe Myoclonic Epilepsy

SCN1B SCN9A

1.30e-03131232C0751122
DiseaseMuscular Dystrophy, Facioscapulohumeral

SMCHD1 HSPA1B

1.30e-03131232C0238288
DiseaseMetastatic melanoma

ALPK3 PEAK1 CDK6

1.50e-03541233C0278883
Diseasenephroblastoma (is_implicated_in)

IGF2R BRCA2

1.52e-03141232DOID:2154 (is_implicated_in)
Diseasetriglycerides in LDL measurement

APOB IGF2R SYNE2

1.67e-03561233EFO_0022320
DiseaseAutosomal recessive primary microcephaly

WDR62 CDK6

1.75e-03151232cv:C3711387
Diseasehair color

FRAS1 SPIRE2 TNFRSF9 GRM5 SYNE2 FMN2

1.98e-033111236EFO_0003924
DiseaseNeuralgia, Supraorbital

GRM5 SCN9A

1.99e-03161232C0038870
DiseaseNeuralgia

GRM5 SCN9A

1.99e-03161232C0027796
Diseaseneutrophil collagenase measurement

CPNE1 HSPA1L

1.99e-03161232EFO_0008248
DiseaseNeuralgia, Atypical

GRM5 SCN9A

1.99e-03161232C0234247
DiseaseNeuralgia, Stump

GRM5 SCN9A

1.99e-03161232C0234249
DiseaseNeuralgia, Iliohypogastric Nerve

GRM5 SCN9A

1.99e-03161232C0423712
DiseaseNeuralgia, Perineal

GRM5 SCN9A

1.99e-03161232C0423711
DiseaseParoxysmal Nerve Pain

GRM5 SCN9A

1.99e-03161232C0751373
DiseaseNerve Pain

GRM5 SCN9A

1.99e-03161232C0751372
DiseaseNeuralgia, Ilioinguinal

GRM5 SCN9A

1.99e-03161232C0751371
DiseaseNeuralgia, Vidian

GRM5 SCN9A

1.99e-03161232C0042656
Diseasebrain measurement, neuroimaging measurement

DIP2B FAT3 CADPS PYGB CATSPERB FAM53B AGBL1 CDK6

2.20e-035501238EFO_0004346, EFO_0004464
Diseasemajor depressive disorder (is_implicated_in)

HSPA1A HSPA1L

2.25e-03171232DOID:1470 (is_implicated_in)
Diseasesphingomyelin 14:0 measurement

TRPM3 SYNE2

2.25e-03171232EFO_0010390
Diseasebitter alcoholic beverage consumption measurement

FBXO40 POLR2B ADRA1A AGBL1

2.37e-031331234EFO_0010092
Diseaseacute lymphoblastic leukemia

LHPP ZNF230 AGBL1

2.67e-03661233EFO_0000220
Diseasenon-high density lipoprotein cholesterol measurement

DIP2B APOB IGF2R BRCA2 RABGAP1L SYNE2 SORCS2 PYGB NR1H4

3.05e-037131239EFO_0005689
Diseasevenous thromboembolism

LHPP ADAMTS13 TBC1D4 TRPM3 CATSPERB DLEC1 AGBL1

3.22e-034601237EFO_0004286
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

DIP2B ANPEP MROH1 CPNE1 CDK6

3.33e-032391235EFO_0010934
DiseaseAutosomal Recessive Primary Microcephaly

WDR62 CDK6

3.77e-03221232C3711387
Diseasechronic widespread pain

DIP2B WDR70

4.12e-03231232EFO_0010099

Protein segments in the cluster

PeptideGeneStartEntry
KRTEEGRLSTSSCAS

nan

116

Q6ZR03
VFTIFASCDSKRTDV

AQP4

171

P55087
VTFERNRTLSESSSC

CATSPERB

316

Q9H7T0
RSLEATCEKLSRSNS

CTAGE9

126

A4FU28
TVSKDQSSCTTARVR

ADRA1A

411

P35348
QSSCTTARVRSKSFL

ADRA1A

416

P35348
DSTTRTGCTIKVDFN

CEACAM16

231

Q2WEN9
TTESCEVERLFKATS

SH3BP2

461

P78314
KSRSVSEDSDVRFTC

ALPK3

286

Q96L96
SRGVCRTKSTSDNET

CACNG3

36

O60359
RQTTRKICSSSDEEN

BRWD3

876

Q6RI45
STVEECFQSLRRKNS

ARAP2

416

Q8WZ64
DVCTVSRTDRETKLT

CDK6

81

Q00534
SSTVRFTCKEATDVI

ANPEP

106

P15144
KDVKISVSFTESCRS

DGCR8

116

Q8WYQ5
SVSFTESCRSKDRKV

DGCR8

121

Q8WYQ5
KTVSATCTDVLRNSF

CCDC14

291

Q49A88
TFSSKTNTLVVRQRC

ADAMTS13

1261

Q76LX8
SCSFLVEKSRASTAR

AGBL1

956

Q96MI9
TNRVCSKRGTTESKE

R3HCC1L

101

Q7Z5L2
FQRARVSSSDVTCAT

RTN4RL2

276

Q86UN3
RASCFKVTKRDEDSS

RC3H1

251

Q5TC82
ITENRSKKTSFFRCS

RAB8B

191

Q92930
RDLRQVTSTTKSCRE

NR1H4

241

Q96RI1
RFVRVNTLKTCSDDV

NSUN5

136

Q96P11
IRSTEGRSKAFSTCS

OR8G2P

241

Q6IF36
KTSRSTDFRVPQSIC

CADPS

1121

Q9ULU8
RTSKVRCSTRDGSAQ

FRAS1

3071

Q86XX4
LVRCVDGSSSSFRSK

GRM5

126

P41594
TCRTTVFKSVTNRFI

GPR176

66

Q14439
SKTRASEVQEPFSRC

GREB1

1701

Q4ZG55
FSSSRQRCFSSKVCV

NADK2

386

Q4G0N4
EKTRVACQASSERNF

MYO19

221

Q96H55
VVSAVQSRCKTAASR

KRT80

401

Q6KB66
ECIKLSEETTTSSSR

CWC22

566

Q9HCG8
SECRVLKSSYSRSSA

DCLK2

286

Q8N568
QKTTSSLDRRFESAQ

ECE2

441

P0DPD6
KRQCRSLSFSDEMSS

FAM53B

111

Q14153
ACERAKRTLSSSTQA

HSPA1B

266

P0DMV9
SIASSEERRKAFNTC

OR51F2

241

Q8NH61
EERRKAFNTCTSHIS

OR51F2

246

Q8NH61
QSSEDRRKAVSTCGS

OR4S1

226

Q8NGB4
RDKTSTCDTYSELSR

MUC19

681

Q7Z5P9
LVSRCRAKATASQSS

PTGER3

256

P43115
ESRSETASSLSQKIC

PEAK1

351

Q9H792
KRRSTFVQSPADACT

DIP2B

126

Q9P265
VRKASRSFQCARSTS

KDM4C

366

Q9H3R0
SSSKRTECSVARESQ

HOXD9

186

P28356
RTACERAKRTLSSST

HSPA1L

266

P34931
RFCTNESQKSRAELV

LHPP

51

Q9H008
LCSRSSVESQVTFKS

LRIT3

656

Q3SXY7
ESLAARQKDTCASVR

MROH1

1366

Q8NDA8
RRDSVESGCQTESSK

NIM1K

21

Q8IY84
SFCTAFKRSSRQVSD

RABGAP1L

246

Q5R372
SCSTDFKTTRSREQV

ITPKA

341

P23677
NTRSLKATTEELFTC

PPP1R3A

691

Q16821
REDSLTCVAATTFQK

EVA1C

106

P58658
GTADSRSATRINCKV

APOB

66

P04114
LIKSFDRTESQRCES

CEFIP

146

Q711Q0
TATLSKRNRECLQES

IFT52

266

Q9Y366
EQCKRRTILTTSNSF

DOCK11

1881

Q5JSL3
SRDVFSISTLVCSTK

DOCK2

596

Q92608
SSFGTILRKCSRNET

BRCA2

661

P51587
DTEEISCRTSSRKRA

BCL10

51

O95999
VSSKSFSCRETRVAQ

FAT3

676

Q8TDW7
IIRTSSGTSREKTAC

FAM98B

281

Q52LJ0
SECVTRRHNKSSSAF

FBXO40

461

Q9UH90
SFCRTSNRKSLIVTS

MAST2

166

Q6P0Q8
RTACERAKRTLSSST

HSPA6

266

P17066
ACERAKRTLSSSTQA

HSPA1A

266

P0DMV8
RITSSLTSEEKECNF

CCDC168

111

Q8NDH2
TSQIDDSFSTKSCRV

CRYBG1

1436

Q9Y4K1
VSTVRTCAKSDLDQR

HELZ2

2561

Q9BYK8
FQSTFSESICSIRRK

FMN2

1456

Q9NZ56
SKTRRSLASRTNECQ

DLEC1

6

Q9Y238
SVFSERTETLKSGCV

COL6A6

416

A6NMZ7
RTETVRSCTSESTAF

CPT1B

601

Q92523
RTERVRNCSSPEFSK

CPNE1

46

Q99829
CQLTLSSSKTVSEDR

POM121L1P

146

Q3SYA9
ACERAKRTLSSSTQA

HSPA8

266

P11142
RITSAEGRNKAFSTC

OR2K2

226

Q8NGT1
LQSTDVEKIFCASSR

MROH2A

1051

A6NES4
RKKSTTIRFTCSESQ

IGF2R

1466

P11717
SFVVRTNTCGELRSS

DARS2

46

Q6PI48
QRTFLLTTSSKEDTC

TAX1BP1

336

Q86VP1
CSKESLSSRTEAVRE

SPAG5

216

Q96R06
KSRSRENSVCSDTSE

URI1

411

O94763
TTSRKEITCDNFDET

SMCHD1

76

A6NHR9
AFSASARKVVNRDSC

SYNE1

1611

Q8NF91
FSSEEDRSSSCLQAK

SYNE2

1141

Q8WXH0
KGRSFTSALTSRVCE

SORCS2

686

Q96PQ0
KVRLNRSSSSECSTV

SCN9A

1116

Q15858
ESTNRRYTKRDCSTF

POLR2B

881

P30876
IKSDNVTRACSFIRE

NIT2

16

Q9NQR4
QSCSDTAQERAKSRV

RNF169

291

Q8NCN4
RRNIAVTTSMSCTDF

ITGAL

696

P20701
TSCAESFRVDLDKSV

PLEKHO1

201

Q53GL0
KVSEARECFTRSINI

EXO1

111

Q9UQ84
SCRDRTQEFLSACKS

STX5

56

Q13190
RTESFDVVTKCVSFT

CLDND1

96

Q9NY35
NECSRTFSRKSSLTR

ZNF845

386

Q96IR2
KALTRSDDVSVCSVS

TBC1D14

146

Q9P2M4
VTDRTSNTKLDCSSF

ZFP28

321

Q8NHY6
SECGKSFSRSSNRIR

ZNF691

146

Q5VV52
TELTRLFQKCRTSGS

SRP14

11

P37108
SCIERKTEITSTAET

SLCO4C1

546

Q6ZQN7
ECTSFVADVVRSSRK

SPIRE2

671

Q8WWL2
AESNKIRSRTSSDCT

TRPM3

1301

Q9HCF6
EPTSSRSNVVRDCSK

WDR70

81

Q9NW82
RSNVVRDCSKSSSRD

WDR70

86

Q9NW82
ISCKRRSETNAETFT

SCN1B

41

Q07699
CSLARRSSTVRKQDS

SRGAP2

486

O75044
ESCTSDTKARRRSFS

KCNJ16

361

Q9NPI9
VFRTRKECSSTSNAE

TNFRSF9

71

Q07011
IACSGKFSSDRTITE

PYGB

806

P11216
TKSRSCFNLSDDIRV

ZBED8

556

Q8IZ13
CEERGKVFSRSTLTN

ZNF716

271

A6NP11
SFCETKQETAVRASI

USP50

246

Q70EL3
RKRTSSTCSNESLSV

TBC1D4

746

O60343
TSTSRNVKRACSDLE

SPOCK3

191

Q9BQ16
KVSCRVIALSFSEDS

WDR62

196

O43379
RGKEFSQSSCLQTRE

ZNF230

201

Q9UIE0
ETFSTRRVKSGLCSQ

WDR27

256

A2RRH5
RDKSLSCTQEDRAFS

SLC9A7

126

Q96T83
TESSKATNVCTRFED

SMARCA5

156

O60264
ARSTLDSATSAKCRQ

TMEM271

196

A0A286YF58
SGSEQFVRRESCTSR

ZNF185

521

O15231
LSFTNVVRQSRKCTT

ZMYM3

1231

Q14202
DRTFESSQIESVKRC

ZC3H13

1376

Q5T200
ASSASESQRISCRLK

ZNF816

186

Q0VGE8
RQLSADAAVTRKTCS

ELFN2

616

Q5R3F8
KNSSQETCTRARELA

NADSYN1

421

Q6IA69
NRISRESSVDCLKES

MYO9A

1216

B2RTY4
KRVDCSSFVIESAQR

MYBPC2

596

Q14324