Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	pantetheine hydrolase activity	VNN2 VNN1	2.93e-05	3	63	2	GO:0017159
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF5 PRAMEF26 PRAMEF6	3.85e-04	47	63	3	GO:0031462
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	PRAMEF5 KCTD13 KCTD10 PRAMEF26 PRAMEF6	4.46e-04	212	63	5	GO:0031461
MousePheno	increased male germ cell apoptosis	ANKRD31 FANCB SETX PRAMEF5 PRAMEF26 PRAMEF6	1.97e-05	189	42	6	MP:0014052
MousePheno	abnormal male germ cell apoptosis	ANKRD31 FANCB SETX PRAMEF5 PRAMEF26 PRAMEF6	6.85e-05	236	42	6	MP:0008280
MousePheno	azoospermia	ANKRD31 SETX PRAMEF5 ATM PRAMEF26 PRAMEF6	8.24e-05	244	42	6	MP:0005159
MousePheno	abnormal male germ cell physiology	ANKRD31 FANCB SETX PRAMEF5 PRAMEF26 PRAMEF6	8.24e-05	244	42	6	MP:0020362
MousePheno	abnormal dorsal aorta morphology	KCTD10 ELP1 PTK2 SMAD2	9.90e-05	81	42	4	MP:0004787
MousePheno	absent gametes	ANKRD31 SETX PRAMEF5 ATM PRAMEF26 PRAMEF6	1.07e-04	256	42	6	MP:0001117
MousePheno	abnormal germ cell physiology	ANKRD31 FANCB SETX PRAMEF5 PRAMEF26 PRAMEF6	1.35e-04	267	42	6	MP:0020363
MousePheno	decreased renal tubule apoptosis	THBS1 SOSTDC1	2.44e-04	8	42	2	MP:0011372
MousePheno	abnormal primary sex determination	ANKRD31 FANCB SETX PRAMEF5 KCTD13 TMPRSS2 ATM PRAMEF26 ZFPM2 PRAMEF6	2.61e-04	901	42	10	MP:0002211
MousePheno	abnormal spermatogonia proliferation	PRAMEF5 PRAMEF26 PRAMEF6	3.73e-04	47	42	3	MP:0002685
MousePheno	abnormal sex determination	ANKRD31 FANCB SETX PRAMEF5 KCTD13 TMPRSS2 ATM PRAMEF26 ZFPM2 PRAMEF6	3.83e-04	945	42	10	MP:0002210
MousePheno	abnormal male reproductive system physiology	ANKRD31 FANCB SLC9C1 SETX PRAMEF5 KCTD13 GLRB TMPRSS2 ATM PRAMEF26 USP19 PRAMEF6	3.84e-04	1329	42	12	MP:0003698
MousePheno	decreased kidney apoptosis	THBS1 SOSTDC1	3.91e-04	10	42	2	MP:0011371
MousePheno	abnormal seminiferous tubule epithelium morphology	ANKRD31 FANCB SETX KCTD13	4.49e-04	120	42	4	MP:0011750
MousePheno	abnormal sperm number	ANKRD31 FANCB SETX PRAMEF5 KCTD13 ATM PRAMEF26 PRAMEF6	4.63e-04	624	42	8	MP:0002673
MousePheno	decreased circulating parathyroid hormone level	GCM2 CASR	4.76e-04	11	42	2	MP:0002905
MousePheno	decreased male germ cell number	ANKRD31 FANCB SETX PRAMEF5 KCTD13 ATM PRAMEF26 PRAMEF6	5.48e-04	640	42	8	MP:0004901
MousePheno	abnormal DNA repair	ANKRD31 FANCB SETX ATM	6.08e-04	130	42	4	MP:0008058
MousePheno	small testis	ANKRD31 FANCB SETX PRAMEF5 KCTD13 TMPRSS2 ATM PRAMEF26 PRAMEF6	6.25e-04	823	42	9	MP:0001147
MousePheno	abnormal artery development	KCTD10 ELP1 PTK2 SMAD2	6.62e-04	133	42	4	MP:0003410
Domain	-	PIK3C2G ATM TRRAP	1.80e-05	16	61	3	1.10.1070.11
Domain	PI3Kc	PIK3C2G ATM TRRAP	1.80e-05	16	61	3	SM00146
Domain	PI3/4_kinase_cat_dom	PIK3C2G ATM TRRAP	2.61e-05	18	61	3	IPR000403
Domain	PI3_PI4_kinase	PIK3C2G ATM TRRAP	2.61e-05	18	61	3	PF00454
Domain	PI3_4_KINASE_3	PIK3C2G ATM TRRAP	2.61e-05	18	61	3	PS50290
Domain	PI3_4_KINASE_1	PIK3C2G ATM TRRAP	2.61e-05	18	61	3	PS00915
Domain	PI3_4_KINASE_2	PIK3C2G ATM TRRAP	2.61e-05	18	61	3	PS00916
Domain	Biotinidase_euk	VNN2 VNN1	6.27e-05	4	61	2	IPR012101
Domain	DUF4371	ZMYM1 ZMYM6	1.04e-04	5	61	2	IPR025398
Domain	DUF4371	ZMYM1 ZMYM6	1.04e-04	5	61	2	PF14291
Domain	FAT	ATM TRRAP	1.56e-04	6	61	2	PS51189
Domain	FATC	ATM TRRAP	1.56e-04	6	61	2	PS51190
Domain	FAT	ATM TRRAP	1.56e-04	6	61	2	PF02259
Domain	PIK-rel_kinase_FAT	ATM TRRAP	1.56e-04	6	61	2	IPR003151
Domain	FATC_dom	ATM TRRAP	1.56e-04	6	61	2	IPR003152
Domain	PIK_FAT	ATM TRRAP	1.56e-04	6	61	2	IPR014009
Domain	FATC	ATM TRRAP	1.56e-04	6	61	2	SM01343
Domain	Znf_MYM	ZMYM1 ZMYM6	2.18e-04	7	61	2	IPR010507
Domain	zf-FCS	ZMYM1 ZMYM6	2.18e-04	7	61	2	PF06467
Domain	TRASH_dom	ZMYM1 ZMYM6	2.90e-04	8	61	2	IPR011017
Domain	TRASH	ZMYM1 ZMYM6	2.90e-04	8	61	2	SM00746
Domain	CN_hydrolase	VNN2 VNN1	2.90e-04	8	61	2	PF00795
Domain	-	VNN2 VNN1	2.90e-04	8	61	2	3.60.110.10
Domain	CN_HYDROLASE	VNN2 VNN1	2.90e-04	8	61	2	PS50263
Domain	C-N_Hydrolase	VNN2 VNN1	2.90e-04	8	61	2	IPR003010
Domain	Oxysterol-bd	OSBPL1A OSBPL6	6.78e-04	12	61	2	IPR000648
Domain	Oxysterol-bd_CS	OSBPL1A OSBPL6	6.78e-04	12	61	2	IPR018494
Domain	Oxysterol_BP	OSBPL1A OSBPL6	6.78e-04	12	61	2	PF01237
Domain	OSBP	OSBPL1A OSBPL6	6.78e-04	12	61	2	PS01013
Domain	PI3/4_kinase_CS	PIK3C2G ATM	1.07e-03	15	61	2	IPR018936
Domain	USP_CS	USP8 USP4 USP19	1.31e-03	66	61	3	IPR018200
Domain	USP_1	USP8 USP4 USP19	1.55e-03	70	61	3	PS00972
Domain	UCH	USP8 USP4 USP19	1.62e-03	71	61	3	PF00443
Domain	USP_2	USP8 USP4 USP19	1.62e-03	71	61	3	PS00973
Domain	USP_3	USP8 USP4 USP19	1.68e-03	72	61	3	PS50235
Domain	USP_dom	USP8 USP4 USP19	1.68e-03	72	61	3	IPR028889
Domain	Peptidase_C19_UCH	USP8 USP4 USP19	1.68e-03	72	61	3	IPR001394
Domain	PRAME_family	PRAMEF5 PRAMEF6	1.73e-03	19	61	2	IPR026271
Domain	RHOD	USP8 CDC25C	2.32e-03	22	61	2	SM00450
Domain	RHODANESE_3	USP8 CDC25C	2.54e-03	23	61	2	PS50206
Domain	Rhodanese-like_dom	USP8 CDC25C	2.77e-03	24	61	2	IPR001763
Domain	Rhodanese	USP8 CDC25C	2.77e-03	24	61	2	PF00581
Domain	-	USP8 CDC25C	2.77e-03	24	61	2	3.40.250.10
Domain	ARM-type_fold	DOCK11 PIK3C2G HEATR1 ATM TRRAP	4.96e-03	339	61	5	IPR016024
Domain	RAS	DIRAS1 DIRAS2	5.83e-03	35	61	2	PS51421
Domain	Small_GTPase_Ras	DIRAS1 DIRAS2	6.49e-03	37	61	2	IPR020849
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP8 USP4 TNKS2 TRRAP USP19 SMAD2	3.00e-05	191	45	6	MM15289
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP8 USP4 TNKS2 TRRAP USP19 SMAD2	6.78e-05	221	45	6	M27578
Pubmed	Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6.	VNN2 VNN1	3.33e-06	2	64	2	9790769
Pubmed	Whole exome sequencing of Rett syndrome-like patients reveals the mutational diversity of the clinical phenotype.	ANKRD31 CHRNA5	3.33e-06	2	64	2	27541642
Pubmed	A Mercaptoacetamide-Based Class II Histone Deacetylase Inhibitor Suppresses Cell Migration and Invasion in Monomorphic Malignant Human Glioma Cells by Inhibiting FAK/STAT3 Signaling.	PTK2 STAT3	3.33e-06	2	64	2	28498494
Pubmed	The Increase of pFAK and THBS1 Protein and Gene Expression Levels in Vascular Smooth Muscle Cells by Histamine-treated M1 Macrophages.	THBS1 PTK2	3.33e-06	2	64	2	30848575
Pubmed	Intermittent hypoxia mediated by TSP1 dependent on STAT3 induces cardiac fibroblast activation and cardiac fibrosis.	THBS1 STAT3	3.33e-06	2	64	2	31934850
Pubmed	Reduced FAK-STAT3 signaling contributes to ER stress-induced mitochondrial dysfunction and death in endothelial cells.	PTK2 STAT3	3.33e-06	2	64	2	28495589
Pubmed	Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background.	GCM2 CASR	3.33e-06	2	64	2	12671052
Pubmed	The hunting of the snark: the elusive calcium receptor(s).	GCM2 CASR	3.33e-06	2	64	2	12671040
Pubmed	Glial cells missing-2 (GCM2) transactivates the calcium-sensing receptor gene: effect of a dominant-negative GCM2 mutant associated with autosomal dominant hypoparathyroidism.	GCM2 CASR	3.33e-06	2	64	2	18712808
Pubmed	Calcium-sensing receptor expression is regulated by glial cells missing-2 in human parathyroid cells.	GCM2 CASR	3.33e-06	2	64	2	19257819
Pubmed	Calcium-sensing receptor abrogates secretagogue- induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction.	GCM2 CASR	3.33e-06	2	64	2	16760252
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF5 STAT3 PRAMEF6	6.63e-06	20	64	3	21425410
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF5 PRAMEF26 PRAMEF6	8.93e-06	22	64	3	31729367
Pubmed	STAT3β disrupted mitochondrial electron transport chain enhances chemosensitivity by inducing pyroptosis in esophageal squamous cell carcinoma.	GSDME STAT3	9.99e-06	3	64	2	34571081
Pubmed	Genetic and clinical characteristics of korean patients with isolated hypoparathyroidism: from the Korean hypopara registry study.	GCM2 CASR	9.99e-06	3	64	2	24133354
Pubmed	Pectenotoxin-2 induces G2/M phase cell cycle arrest in human breast cancer cells via ATM and Chk1/2-mediated phosphorylation of cdc25C.	ATM CDC25C	9.99e-06	3	64	2	20514472
Pubmed	ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres.	ATM CDC25C	9.99e-06	3	64	2	22842784
Pubmed	Milk fat globule EGF factor 8 restores mitochondrial function via integrin-medicated activation of the FAK-STAT3 signaling pathway in acute pancreatitis.	PTK2 STAT3	9.99e-06	3	64	2	33634976
Pubmed	FGL1: a novel biomarker and target for non-small cell lung cancer, promoting tumor progression and metastasis through KDM4A/STAT3 transcription mechanism.	KDM4A STAT3	9.99e-06	3	64	2	39085849
Pubmed	STAT3 and PD-L1 are negatively correlated with ATM and have impact on the prognosis of triple-negative breast cancer patients with low ATM expression.	ATM STAT3	9.99e-06	3	64	2	36056297
Pubmed	Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes.	VNN2 VNN1	9.99e-06	3	64	2	11491533
Pubmed	Analysis of Expression of the ANG1, CaSR and FAK Proteins in Uterine Fibroids.	CASR PTK2	9.99e-06	3	64	2	39000274
Pubmed	Thrombospondin-1 induced programmed death-ligand 1-mediated immunosuppression by activating the STAT3 pathway in osteosarcoma.	THBS1 STAT3	9.99e-06	3	64	2	34927311
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF5 PRAMEF26 PRAMEF6	1.33e-05	25	64	3	37451217
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF5 STAT3 PRAMEF6	1.50e-05	26	64	3	18500982
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF5 PRAMEF26 PRAMEF6	1.88e-05	28	64	3	25089626
Pubmed	The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation.	STAT3 SMAD2	2.00e-05	4	64	2	32827457
Pubmed	Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation.	STAT3 SMAD2	2.00e-05	4	64	2	26194464
Pubmed	ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1.	ATM CDC25C	2.00e-05	4	64	2	11390642
Pubmed	VPS35 promotes gastric cancer progression through integrin/FAK/SRC signalling-mediated IL-6/STAT3 pathway activation in a YAP-dependent manner.	PTK2 STAT3	2.00e-05	4	64	2	37950040
Pubmed	Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B.	USP8 USP4	2.00e-05	4	64	2	18728397
Pubmed	Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-β therapy in multiple sclerosis patients.	DENND3 PTK2	2.00e-05	4	64	2	21502966
Pubmed	The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways.	PTK2 STAT3	2.00e-05	4	64	2	21643014
Pubmed	Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly.	THBS1 PTK2	2.00e-05	4	64	2	15371459
Pubmed	Perilipin 5 Ameliorates Hepatic Stellate Cell Activation via SMAD2/3 and SNAIL Signaling Pathways and Suppresses STAT3 Activation.	STAT3 SMAD2	2.00e-05	4	64	2	34571833
Pubmed	SOCS3 promoter methylation is mutually exclusive to EGFR amplification in gliomas and promotes glioma cell invasion through STAT3 and FAK activation.	PTK2 STAT3	2.00e-05	4	64	2	21590492
Pubmed	Ascochlorin Suppresses MMP-2-Mediated Migration and Invasion by Targeting FAK and JAK-STAT Signaling Cascades.	PTK2 STAT3	2.00e-05	4	64	2	28569433
Pubmed	Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2.	GCM2 CASR	2.00e-05	4	64	2	20484821
Pubmed	Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin.	PTK2 STAT3	2.00e-05	4	64	2	10925297
Pubmed	R-loops in proliferating cells but not in the brain: implications for AOA2 and other autosomal recessive ataxias.	SETX ATM	2.00e-05	4	64	2	24637776
Pubmed	MicroRNA-10a silencing reverses cisplatin resistance in the A549/cisplatin human lung cancer cell line via the transforming growth factor-β/Smad2/STAT3/STAT5 pathway.	STAT3 SMAD2	2.00e-05	4	64	2	25586740
Pubmed	Gcm2 regulates the maintenance of parathyroid cells in adult mice.	GCM2 CASR	2.00e-05	4	64	2	30677043
Pubmed	Interleukin-6 Induces Vascular Endothelial Growth Factor-C Expression via Src-FAK-STAT3 Signaling in Lymphatic Endothelial Cells.	PTK2 STAT3	2.00e-05	4	64	2	27383632
Pubmed	Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.	ATM CDC25C	2.00e-05	4	64	2	16481012
Pubmed	Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity.	ATM CDC25C	2.00e-05	4	64	2	10744722
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	USP8 THBS1 ATP13A1 OSBPL1A HECTD4 KDM4A ATM TNKS2 PTK2 STAT3 SMAD2	2.07e-05	1285	64	11	35914814
Pubmed	SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination.	SHLD1 ATM	3.32e-05	5	64	2	35764636
Pubmed	USP8 promotes cancer progression and extracellular vesicle-mediated CD8+ T cell exhaustion by deubiquitinating the TGF-β receptor TβRII.	USP8 SMAD2	3.32e-05	5	64	2	35811497
Pubmed	Chk2 activation and phosphorylation-dependent oligomerization.	ATM CDC25C	3.32e-05	5	64	2	12024051
Pubmed	The CRL3BTBD9 E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration.	KCTD13 KCTD10	3.32e-05	5	64	2	32327643
Pubmed	Di-Ras, a distinct subgroup of ras family GTPases with unique biochemical properties.	DIRAS1 DIRAS2	3.32e-05	5	64	2	12194967
Pubmed	RUNX1 and TGF-β signaling cross talk regulates Ca2+ ion channels expression and activity during megakaryocyte development.	THBS1 LTBP2 SMAD2	3.73e-05	35	64	3	32281291
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF5 PRAMEF26 PRAMEF6	3.73e-05	35	64	3	19389355
Pubmed	Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism.	OSBPL1A OSBPL6	4.98e-05	6	64	2	10588946
Pubmed	The proinflammatory cytokine, interleukin-6, up-regulates calcium-sensing receptor gene transcription via Stat1/3 and Sp1/3.	CASR STAT3	4.98e-05	6	64	2	18348986
Pubmed	Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.	KCTD13 KCTD10	4.98e-05	6	64	2	28963344
Pubmed	Leptin augments myofibroblastic conversion and fibrogenic activity of human peritoneal mesothelial cells: a functional implication for peritoneal fibrosis.	STAT3 SMAD2	4.98e-05	6	64	2	17142261
Pubmed	Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28.	STAT3 SMAD2	4.98e-05	6	64	2	29651155
Pubmed	Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.	ATM CDC25C	4.98e-05	6	64	2	12660173
Pubmed	Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling.	PTK2 STAT3	4.98e-05	6	64	2	23920124
Pubmed	Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3.	THBS1 PTK2	4.98e-05	6	64	2	9169439
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	TRIML1 PRAMEF5 DOCK11 HECTD4 USP19 PRAMEF6	5.58e-05	363	64	6	14691545
Pubmed	Trp53 deficiency protects against acute intestinal inflammation.	ATM STAT3	6.96e-05	7	64	2	23772033
Pubmed	Deubiquitylation and stabilization of PTEN by USP13.	USP8 USP4	6.96e-05	7	64	2	24270891
Pubmed	Elongator and codon bias regulate protein levels in mammalian peripheral neurons.	SETX ELP1	6.96e-05	7	64	2	29497044
Pubmed	Ataxia telangiectasia mutated proteins, MAPKs, and RSK2 are involved in the phosphorylation of STAT3.	ATM STAT3	6.96e-05	7	64	2	12562765
Pubmed	Elevated lung cancer risk is associated with deficiencies in cell cycle checkpoints: genotype and phenotype analyses from a case-control study.	ATM CDC25C	6.96e-05	7	64	2	19626602
Pubmed	DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase.	ATM CDC25C	6.96e-05	7	64	2	12937170
Pubmed	USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling.	USP4 SMAD2	6.96e-05	7	64	2	28468752
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	USP8 KCTD13 KCTD10 PHLPP1 USP4 KDM4A TRRAP ZMYM6 USP19	8.98e-05	1005	64	9	19615732
Pubmed	p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress.	ATM CDC25C	9.27e-05	8	64	2	16705183
Pubmed	Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype.	ATM CDC25C	9.27e-05	8	64	2	16540636
Pubmed	USP4 Auto-Deubiquitylation Promotes Homologous Recombination.	USP4 SMAD2	9.27e-05	8	64	2	26455393
Pubmed	Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination.	KCTD10 USP19	9.27e-05	8	64	2	31511519
Pubmed	USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor.	USP4 USP19	9.27e-05	8	64	2	22706160
Pubmed	The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types.	USP8 USP4	1.19e-04	9	64	2	22195557
Pubmed	Interactions between BMP-7 and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations.	SOSTDC1 SMAD2	1.19e-04	9	64	2	24816837
Pubmed	Using real time RT-PCR analysis to determine multiple gene expression patterns during XX and XY mouse fetal gonad development.	VNN1 SOSTDC1 ZFPM2	1.38e-04	54	64	3	15533830
Pubmed	KCTD10 regulates brain development by destabilizing brain disorder-associated protein KCTD13.	KCTD13 KCTD10	1.49e-04	10	64	2	38489388
Pubmed	Tel2 regulates the stability of PI3K-related protein kinases.	ATM TRRAP	1.49e-04	10	64	2	18160036
Pubmed	Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.	ATM TRRAP	1.81e-04	11	64	2	20427287
Pubmed	Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.	ATM CDC25C	1.81e-04	11	64	2	11551930
Pubmed	The OSBP-related protein family in humans.	OSBPL1A OSBPL6	1.81e-04	11	64	2	11483621
Pubmed	Activator-Mediator binding regulates Mediator-cofactor interactions.	ATM TRRAP	1.81e-04	11	64	2	20534441
Pubmed	HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells.	PIK3C2G PTK2	1.81e-04	11	64	2	9708406
Pubmed	Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner.	THBS1 SMAD2	1.81e-04	11	64	2	38678560
Pubmed	Colony-stimulating factor-1 requires PI3-kinase-mediated metabolism for proliferation and survival in myeloid cells.	PIK3C2G STAT3	2.17e-04	12	64	2	16514418
Pubmed	A family of 12 human genes containing oxysterol-binding domains.	OSBPL1A OSBPL6	2.17e-04	12	64	2	11735225
Pubmed	An oxysterol-binding protein family identified in the mouse.	OSBPL1A OSBPL6	2.17e-04	12	64	2	12215260
Pubmed	Photocaged Cell-Permeable Ubiquitin Probe for Temporal Profiling of Deubiquitinating Enzymes.	USP8 USP4 USP19	2.29e-04	64	64	3	33141564
Pubmed	Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 deficient mouse.	SOSTDC1 SMAD2	2.57e-04	13	64	2	18329379
Pubmed	Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract.	PTK2 SMAD2	2.99e-04	14	64	2	34270692
Pubmed	Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia.	GCM2 CASR	2.99e-04	14	64	2	17382312
Pubmed	The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features.	FANCB ATM	3.45e-04	15	64	2	19536649
Pubmed	Deubiquitinating enzymes: a new class of biological regulators.	USP8 USP4	3.45e-04	15	64	2	9827704
Pubmed	Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesis.	PTK2 SMAD2	3.45e-04	15	64	2	26151572
Pubmed	Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation.	PTK2 SMAD2	3.45e-04	15	64	2	38018454
Pubmed	Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.	PHLPP1 PTK2 STAT3	3.65e-04	75	64	3	15951569
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	HECTD4 PTK2 USP19 SMAD2	3.68e-04	183	64	4	31932471
Pubmed	Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice.	PIK3C2G STAT3	3.93e-04	16	64	2	20019835
Cytoband	6q23-q24	VNN2 VNN1	6.84e-05	9	64	2	6q23-q24
Cytoband	1p36.21	PRAMEF5 PRAMEF26 PRAMEF6	9.67e-05	63	64	3	1p36.21
GeneFamily	Vanins	VNN2 VNN1	2.52e-05	3	53	2	10
GeneFamily	PRAME family	PRAMEF5 PRAMEF26 PRAMEF6	4.61e-05	24	53	3	686
GeneFamily	Zinc fingers MYM-type	ZMYM1 ZMYM6	1.26e-04	6	53	2	86
GeneFamily	Oxysterol binding proteins\|Pleckstrin homology domain containing	OSBPL1A OSBPL6	5.46e-04	12	53	2	670
GeneFamily	Ubiquitin specific peptidases	USP8 USP4 USP19	5.91e-04	56	53	3	366
GeneFamily	RAS type GTPase family	DIRAS1 DIRAS2	3.71e-03	31	53	2	389
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_C\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CD7 KCTD10 GLRB SOSTDC1 ATM	4.62e-06	170	64	5	81341bf4fe090af70b2091b6b2579ed08d76e22d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CASP8AP2 FANCB CKAP2L CDC25C CHRNA5	5.94e-06	179	64	5	88d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCell	(07)_Ionocytes\|World / shred by cell type by condition	DOCK11 OSBPL1A SOSTDC1 TMPRSS2 LTBP2	9.93e-06	199	64	5	8194777d367405a7840787e977854b5c07e3bd6b
Disease	Hypoparathyroidism familial isolated	GCM2 CASR	1.22e-05	3	60	2	C1832648
Disease	Familial Isolated Hyperparathyroidism	GCM2 CASR	2.43e-05	4	60	2	C4551961
Disease	hyperparathyroidism (is_implicated_in)	GCM2 CASR	4.05e-05	5	60	2	DOID:13543 (is_implicated_in)
Disease	response to interferon-beta	DENND3 PTK2	8.48e-05	7	60	2	GO_0035456
Disease	infertility (implicated_via_orthology)	GCM2 ATM	8.48e-05	7	60	2	DOID:5223 (implicated_via_orthology)
Disease	Fibrosis	THBS1 ATM STAT3	1.46e-04	50	60	3	C0016059
Disease	Cirrhosis	THBS1 ATM STAT3	1.46e-04	50	60	3	C1623038
Disease	cerebellar volume measurement	USP4 DENND3 PTK2	1.65e-04	52	60	3	EFO_0020864
Disease	endometrial hyperplasia (is_marker_for)	CDC25C PTK2	1.81e-04	10	60	2	DOID:0080365 (is_marker_for)
Disease	Psoriasis	VNN2 VNN1 STAT3	2.16e-04	57	60	3	C0033860
Disease	Pustulosis of Palms and Soles	VNN2 VNN1 STAT3	2.16e-04	57	60	3	C0030246
Disease	Copper-Overload Cirrhosis	STAT3 SMAD2	2.21e-04	11	60	2	C1876165
Disease	matrix metalloproteinase 1 measurement	CKAP2L ZFPM2	4.20e-04	15	60	2	EFO_0010588
Disease	head and neck squamous cell carcinoma (is_implicated_in)	FANCB STAT3	4.20e-04	15	60	2	DOID:5520 (is_implicated_in)
Disease	lung small cell carcinoma (is_marker_for)	CHRNA5 PTK2	4.79e-04	16	60	2	DOID:5409 (is_marker_for)
Disease	pancreatic ductal carcinoma (is_implicated_in)	THBS1 HEATR1	4.79e-04	16	60	2	DOID:3587 (is_implicated_in)
Disease	heart disease (biomarker_via_orthology)	THBS1 STAT3	5.42e-04	17	60	2	DOID:114 (biomarker_via_orthology)
Disease	pre-malignant neoplasm (biomarker_via_orthology)	ATM STAT3	5.42e-04	17	60	2	DOID:0060071 (biomarker_via_orthology)
Disease	ovulation	GCM2 KDM4A	6.80e-04	19	60	2	GO_0030728
Disease	atherosclerosis (biomarker_via_orthology)	CASR STAT3	7.55e-04	20	60	2	DOID:1936 (biomarker_via_orthology)
Disease	Congenital diaphragmatic hernia	ZFPM2 STAT3	8.33e-04	21	60	2	C0235833
Disease	Hepatitis, Chronic	STAT3 SMAD2	9.15e-04	22	60	2	C0019189
Disease	Chronic active hepatitis	STAT3 SMAD2	9.15e-04	22	60	2	C0520463
Disease	Cryptogenic Chronic Hepatitis	STAT3 SMAD2	9.15e-04	22	60	2	C0524611
Disease	Chronic Persistent Hepatitis	STAT3 SMAD2	9.15e-04	22	60	2	C0149519
Disease	idiopathic pulmonary fibrosis (is_marker_for)	STAT3 SMAD2	1.00e-03	23	60	2	DOID:0050156 (is_marker_for)
Disease	lung squamous cell carcinoma (is_implicated_in)	ATM CHRNA5	1.09e-03	24	60	2	DOID:3907 (is_implicated_in)
Disease	pancreatic ductal adenocarcinoma (is_marker_for)	VNN1 SMAD2	1.38e-03	27	60	2	DOID:3498 (is_marker_for)
Disease	ovarian carcinoma (is_marker_for)	PTK2 SMAD2	1.49e-03	28	60	2	DOID:4001 (is_marker_for)
Disease	lung small cell carcinoma (is_implicated_in)	ATM PTK2	1.49e-03	28	60	2	DOID:5409 (is_implicated_in)
Disease	JT interval	CASR LTBP2 ZFPM2 STAT3	1.64e-03	248	60	4	EFO_0007885

Protein segments in the cluster

Peptide	Gene	Start	Entry
QKTHTTFKCLSCVKV	ZNF280B	301	Q86YH2
VCCTSIVYATEKKQT	KCTD13	236	Q8WZ19
VCCTSIVYATEKKQT	KCTD10	226	Q9H3F6
VACVLARTQIKKLCS	CD7	196	P09564
ISFVLCISCILVKTN	CASR	686	P41180
TSKLSSIQCICHVIK	ATP13A1	961	Q9HD20
CVLTQKITTMQKCVI	GSDME	156	O60443
CVCKLSSSVKTNLGV	DENND3	721	A2RUS2
NVCSVEKSKPCVSSI	CASP8AP2	1421	Q9UKL3
KICSVLGCVETKQIT	PIK3C2G	436	O75747
CSTSEKAITSKKVLC	ANKRD31	906	Q8N7Z5
TSLTINKCVPVSKCD	ZFPM2	801	Q8WW38
CLDSTACKITITVVL	HRH2	11	P25021
GTSILVSCKKCSVRV	KDM4A	731	O75164
VIISLCCNSKTKSVV	ELP1	556	O95163
STLQVGETRCKKVCT	GLRB	396	P48167
RESCILITKCQTVSK	HECTD4	416	Q9Y4D8
CKHLTQAVCTVKSTD	OSBPL1A	281	Q9BXW6
IRNTKSSVCICKLTF	OSBPL6	751	Q9BZF3
LCLKKTVSLCDITIT	CDC25C	256	P30307
KKECVQIITAVTSLS	FANCB	571	Q8NB91
IIKNCICTNVSVSKL	OR56A5	176	P0C7T3
QVISCDKSVCTLQIT	DIRAS1	46	O95057
KICLCTSVLVSLTVF	CHRNA5	281	P30532
CVKVRSAAVTCLKNI	ATM	1726	Q13315
VLKCCTSKISSTRNE	DOCK11	1486	Q5JSL3
QVISCDKSICTLQIT	DIRAS2	46	Q96HU8
IKIVFTPTICKQTCA	LTBP2	351	Q14767
VILSVLVSCCSSLKE	HEATR1	706	Q9H583
SCLKTSLKVLTITNC	PRAMEF26	196	H0Y7S4
SKSVLLITCKTCNRT	C18orf21	96	Q32NC0
ATCKTVVETCFIPKT	SLC9C1	966	Q4G0N8
VAIKTCKNCTSDSVR	PTK2	451	Q05397
ILKKSCLGVVVCTQA	GCM2	76	O75603
TTVSQKKSSKLCTCT	SETX	1216	Q7Z333
SLSASVCKCLSQKIT	SHLD1	116	Q8IYI0
CIPQTSCVLQKSKAI	CKAP2L	361	Q8IYA6
CLKTSLKVLTITNCV	PRAMEF6	291	Q5VXH4
VCTLLKCKTTNLTTC	VNN2	401	O95498
KSKLVCPVCAKVSIT	USP19	651	O94966
CQNSVTICKKVSCPI	THBS1	341	P07996
LTQCSSTKSKIFQCI	ZNF678	86	Q5SXM1
VCTSKTKKALCITLT	TMPRSS2	76	O15393
KSTLVCPECAKVSVT	USP4	456	Q13107
QICTLLKCKTTNLNT	VNN1	396	O95497
LEKAITTQNCNTKCV	SMAD2	61	Q15796
LKTKFICVTPTTCSN	STAT3	706	P40763
TAVLAQCSECKKTTR	TRIM51	46	Q9BSJ1
CLKTSLKVLTITNCV	PRAMEF5	291	Q5TYX0
STRTYKITVVTACKC	SOSTDC1	151	Q6X4U4
ETVKKLCTVQSVNCR	TNKS2	506	Q9H2K2
CLSTTQSKILQCKAS	ZNF141	136	Q15928
LCQEETKTCKQVVVS	TRIML1	166	Q8N9V2
KVIINATTCTVTCGL	TMEM81	41	Q6P7N7
CVTTTQSKIVQCDKY	ZNF708	131	P17019
ISCKPVTQTKATSCK	ZMYM6	691	O95789
QVILCGTCLIVSSVK	PHLPP1	561	O60346
STTAIQVSCAGCKKI	ZMYM1	81	Q5SVZ6
KPFVTICTNSILTKC	ZMYM1	176	Q5SVZ6
LVVCTLCSCVMKTKQ	RNF145	131	Q96MT1
CRSLVKTLVCGVKTI	TRRAP	546	Q9Y4A5
KSTVQCLTCHKKSRT	USP8	931	P40818
TIATCAKCKSVHKIS	ZNF518B	56	Q9C0D4
CTVCLKTFTAKSTLQ	ZBTB6	356	Q15916
SKVSVTERCFIKVCT	KTN1-AS1	36	Q86SY8