Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmechanosensitive monoatomic ion channel activity

TMC7 TMC8 TMEM63A

3.68e-0518733GO:0008381
GeneOntologyMolecularFunctionphosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity

TPTE TPTE2

1.31e-045732GO:0016314
GeneOntologyMolecularFunctionphosphatidylinositol phosphate phosphatase activity

TPTE MTMR14 TPTE2

1.77e-0430733GO:0052866
GeneOntologyMolecularFunctionprotein tyrosine phosphatase activity

TPTE PTPRF TPTE2 PTPN22

5.53e-04103734GO:0004725
GeneOntologyMolecularFunctioncomplement component C1q complex binding

C4A C4B

5.82e-0410732GO:0001849
GeneOntologyMolecularFunctionphosphoprotein phosphatase activity

TPTE PTPRF MTMR14 TPTE2 PTPN22

6.43e-04189735GO:0004721
GeneOntologyMolecularFunctionphosphatidylinositol trisphosphate phosphatase activity

TPTE TPTE2

7.10e-0411732GO:0034594
GeneOntologyCellularComponentsymbiont cell surface

C4A C4B

3.32e-048732GO:0106139
GeneOntologyCellularComponentother organism part

C4A C4B

4.26e-049732GO:0044217
DomainTyr_Pase_AS

TPTE PTPRF MTMR14 TPTE2 PTPN22

9.70e-0673735IPR016130
Domain-

TPTE PTPRF MTMR14 TPTE2 PTPN22

3.00e-05927353.90.190.10
DomainProt-tyrosine_phosphatase-like

TPTE PTPRF MTMR14 TPTE2 PTPN22

4.27e-0599735IPR029021
DomainAnaphylatoxin_comp_syst

C4A C4B

1.50e-045732IPR018081
DomainNFAT

NFATC2 NFAT5

1.50e-045732IPR008366
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

1.50e-045732IPR001840
DomainANATO

C4A C4B

3.12e-047732SM00104
DomainANATO

C4A C4B

3.12e-047732PF01821
DomainANAPHYLATOXIN_2

C4A C4B

3.12e-047732PS01178
DomainANAPHYLATOXIN_1

C4A C4B

3.12e-047732PS01177
DomainAnaphylatoxin/fibulin

C4A C4B

3.12e-047732IPR000020
DomainTYR_PHOSPHATASE_1

TPTE PTPRF TPTE2 PTPN22

3.58e-0486734PS00383
DomainTYR_PHOSPHATASE_2

TPTE PTPRF TPTE2 PTPN22

3.74e-0487734PS50056
DomainTYR_PHOSPHATASE_dom

TPTE PTPRF TPTE2 PTPN22

3.74e-0487734IPR000387
DomainPTEN_C2

TPTE TPTE2

4.16e-048732SM01326
DomainPTEN_C2

TPTE TPTE2

4.16e-048732PF10409
DomainC2_TENSIN

TPTE TPTE2

4.16e-048732PS51182
DomainTensin_lipid_phosphatase_dom

TPTE TPTE2

4.16e-048732IPR029023
DomainThiol-ester_cl

C4A C4B

4.16e-048732PF10569
DomainMacrogloblnA2_thiol-ester-bond

C4A C4B

4.16e-048732IPR019565
DomainTMC

TMC7 TMC8

4.16e-048732PF07810
DomainMacrogloblnA2_CS

C4A C4B

4.16e-048732IPR019742
DomainTensin_C2-dom

TPTE TPTE2

4.16e-048732IPR014020
DomainTMC

TMC7 TMC8

4.16e-048732IPR012496
DomainPPASE_TENSIN

TPTE TPTE2

5.33e-049732PS51181
DomainA2M_N

C4A C4B

6.64e-0410732PF01835
DomainA2M_N

C4A C4B

6.64e-0410732IPR002890
DomainA-macroglobulin_rcpt-bd

C4A C4B

6.64e-0410732IPR009048
DomainRHD_dimer

NFATC2 NFAT5

6.64e-0410732IPR032397
DomainRHD_dimer

NFATC2 NFAT5

6.64e-0410732PF16179
DomainNFkB/Dor

NFATC2 NFAT5

6.64e-0410732IPR000451
DomainREL_1

NFATC2 NFAT5

6.64e-0410732PS01204
DomainALPHA_2_MACROGLOBULIN

C4A C4B

6.64e-0410732PS00477
DomainRHD_DNA_bind_dom

NFATC2 NFAT5

6.64e-0410732IPR011539
DomainA2M

C4A C4B

6.64e-0410732PF00207
DomainRHD_DNA_bind

NFATC2 NFAT5

6.64e-0410732PF00554
DomainA2M_N_2

C4A C4B

6.64e-0410732IPR011625
DomainA2M_comp

C4A C4B

6.64e-0410732IPR011626
DomainA2M_N_2

C4A C4B

6.64e-0410732PF07703
DomainREL_2

NFATC2 NFAT5

6.64e-0410732PS50254
DomainA2M_recep

C4A C4B

6.64e-0410732PF07677
DomainA2M_comp

C4A C4B

6.64e-0410732PF07678
Domain-

NFATC2 NFAT5

6.64e-04107322.60.40.340
DomainMacroglobln_a2

C4A C4B

6.64e-0410732IPR001599
DomainER_TARGET

HSP90B1 CALR3 ERP44

8.21e-0447733PS00014
DomainHEAT

CEP104 HEATR4 UTP20

8.73e-0448733PF02985
DomainRasGAP

NF1 RASA3

1.33e-0314732SM00323
DomainRasGAP_CS

NF1 RASA3

1.33e-0314732IPR023152
DomainHEAT

CEP104 HEATR4 UTP20

1.52e-0358733IPR000357
DomainRasGAP

NF1 RASA3

1.53e-0315732PF00616
DomainRAS_GTPASE_ACTIV_1

NF1 RASA3

1.53e-0315732PS00509
DomainRAS_GTPASE_ACTIV_2

NF1 RASA3

1.53e-0315732PS50018
Domain-

CEP104 NF1 HEATR4 RRP12 UTP20

1.77e-032227351.25.10.10
DomainC345C

C4A C4B

1.97e-0317732SM00643
DomainARM-type_fold

CEP104 NF1 NOC2L HEATR4 RRP12 UTP20

2.10e-03339736IPR016024
DomainRasGAP_dom

NF1 RASA3

2.21e-0318732IPR001936
DomainTerpenoid_cyclase/PrenylTrfase

C4A C4B

2.21e-0318732IPR008930
DomainHATPase_c

HSP90B1 PDK3

2.21e-0318732SM00387
DomainHATPase_c

HSP90B1 PDK3

2.47e-0319732PF02518
DomainNTR

C4A C4B

2.47e-0319732PF01759
DomainNetrin_module_non-TIMP

C4A C4B

2.47e-0319732IPR018933
DomainHEAT_REPEAT

CEP104 HEATR4 UTP20

2.60e-0370733PS50077
Domain-

HSP90B1 PDK3

2.74e-03207323.30.565.10
DomainHATPase_C

HSP90B1 PDK3

3.02e-0321732IPR003594
DomainNTR

C4A C4B

3.61e-0323732PS50189
DomainNetrin_domain

C4A C4B

3.61e-0323732IPR001134
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

4.59e-06275222737222
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

4.59e-06275216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

4.59e-06275215998580
Pubmed

Structural polymorphism of murine C4 and its linkage to H-2.

C4A C4B

4.59e-0627527373044
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

4.59e-06275219062096
Pubmed

The chemical structure of the C4d fragment of the human complement component C4.

C4A C4B

4.59e-0627523696167
Pubmed

Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.

C4A C4B

4.59e-0627521357031
Pubmed

Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.

C4A C4B

4.59e-06275216098595
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

4.59e-06275219933335
Pubmed

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

C4A C4B

4.59e-0627522459207
Pubmed

Antigen-induced B cell apoptosis is independent of complement C4.

C4A C4B

4.59e-06275217645767
Pubmed

Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.

C4A C4B

4.59e-06275215787745
Pubmed

Anti-DNA autoreactivity in C4-deficient mice.

C4A C4B

4.59e-06275212207352
Pubmed

Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.

C4A C4B

4.59e-06275230026462
Pubmed

A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.

C4A C4B

4.59e-0627526559257
Pubmed

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

C4A C4B

4.59e-06275227758680
Pubmed

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

C4A C4B

4.59e-06275222387014
Pubmed

Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.

C4A C4B

4.59e-06275234299197
Pubmed

Assessment of complement C4 gene copy number using the paralog ratio test.

C4A C4B

4.59e-06275220506482
Pubmed

Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.

C4A C4B

4.59e-06275212480675
Pubmed

Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.

C4A C4B

4.59e-06275226800705
Pubmed

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.

C4A C4B

4.59e-06275223749435
Pubmed

Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.

C4A C4B

4.59e-06275223918728
Pubmed

Murine complement C4 is not required for experimental autoimmune encephalomyelitis.

C4A C4B

4.59e-06275215390104
Pubmed

Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.

C4A C4B

4.59e-0627523037333
Pubmed

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

C4A C4B

4.59e-06275211726230
Pubmed

Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

C4A C4B

4.59e-0627524216347
Pubmed

Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.

C4A C4B

4.59e-0627521699796
Pubmed

Sequence determination of the thiolester site of the fourth component of human complement.

C4A C4B

4.59e-0627526950384
Pubmed

Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.

C4A C4B

4.59e-0627522997024
Pubmed

Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.

C4A C4B

4.59e-0627528660986
Pubmed

Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.

C4A C4B

4.59e-0627523624865
Pubmed

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

C4A C4B

4.59e-0627528428773
Pubmed

Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.

C4A C4B

4.59e-06275221857912
Pubmed

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.

C4A C4B

4.59e-06275224638111
Pubmed

Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.

C4A C4B

4.59e-0627526208559
Pubmed

The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.

C4A C4B

4.59e-0627524514997
Pubmed

Transcriptional repression of C4 complement by hepatitis C virus proteins.

C4A C4B

4.59e-06275221345967
Pubmed

The inheritance of susceptibility to the Gross leukemia virus in mice.

C4A C4B

4.59e-0627525919331
Pubmed

An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.

C4A C4B

4.59e-0627523167981
Pubmed

The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.

C4A C4B

4.59e-0627527545960
Pubmed

Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.

C4A C4B

4.59e-06275230041577
Pubmed

Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

C4A C4B

4.59e-0627522572548
Pubmed

The complement component C4 of mammals.

C4A C4B

4.59e-0627522302180
Pubmed

Complete cDNA sequence of the fourth component of murine complement.

C4A C4B

4.59e-0627523862104
Pubmed

The BS variant of C4 protects against age-related loss of white matter microstructural integrity.

C4A C4B

4.59e-06275234358307
Pubmed

Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.

C4A C4B

4.59e-06275218360261
Pubmed

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

C4A C4B

4.59e-06275222151770
Pubmed

C4d-positive chronic rejection: a frequent entity with a poor outcome.

C4A C4B

4.59e-06275218091514
Pubmed

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.

C4A C4B

4.59e-06275229080553
Pubmed

Schizophrenia risk from complex variation of complement component 4.

C4A C4B

4.59e-06275226814963
Pubmed

Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

C4A C4B

4.59e-0627526589636
Pubmed

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.

C4A C4B

4.59e-06275225339671
Pubmed

A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.

C4A C4B

4.59e-06275217728371
Pubmed

Structure and organization of the C4 genes.

C4A C4B

4.59e-0627526149580
Pubmed

Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.

C4A C4B

4.59e-0627526149581
Pubmed

The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.

C4A C4B

4.59e-06275212115608
Pubmed

Biochemistry and biology of anaphylatoxins.

C4A C4B

4.59e-0627523542363
Pubmed

C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.

C4A C4B

4.59e-0627522387317
Pubmed

Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.

C4A C4B

4.59e-0627528132550
Pubmed

Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.

C4A C4B

4.59e-0627522395880
Pubmed

Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.

C4A C4B

4.59e-06275226814708
Pubmed

cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).

C4A C4B

4.59e-0627526192448
Pubmed

Complete primary structure of human C4a anaphylatoxin.

C4A C4B

4.59e-0627526167582
Pubmed

Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.

C4A C4B

4.59e-06275216908004
Pubmed

Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.

C4A C4B

4.59e-0627521438267
Pubmed

Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.

C4A C4B

4.59e-0627527365238
Pubmed

Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.

C4A C4B

4.59e-06275219150565
Pubmed

Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.

C4A C4B

4.59e-0627527391573
Pubmed

Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.

C4A C4B

4.59e-06275217506029
Pubmed

Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.

C4A C4B

4.59e-06275217971360
Pubmed

Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.

C4A C4B

4.59e-06275223715124
Pubmed

Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.

C4A C4B

4.59e-0627523464002
Pubmed

Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.

C4A C4B

4.59e-0627522993295
Pubmed

Clinical features of patients with homozygous complement C4A or C4B deficiency.

C4A C4B

4.59e-06275229928053
Pubmed

Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.

C4A C4B

4.59e-06275217971229
Pubmed

Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.

C4A C4B

4.59e-0627526881182
Pubmed

Identification of the site of sulfation of the fourth component of human complement.

C4A C4B

4.59e-0627523944109
Pubmed

Polarized PtdIns(4,5)P2 distribution mediated by a voltage-sensing phosphatase (VSP) regulates sperm motility.

TPTE TPTE2

4.59e-06275231776261
Pubmed

Partial C4 deficiency in juvenile idiopathic arthritis patients.

C4A C4B

4.59e-06275217921792
Pubmed

Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.

C4A C4B

4.59e-06275221880985
Pubmed

Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.

C4A C4B

4.59e-0627526978711
Pubmed

Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.

C4A C4B

4.59e-06275235898513
Pubmed

Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.

C4A C4B

4.59e-06275233353966
Pubmed

Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).

C4A C4B

4.59e-0627523008092
Pubmed

Splicing annotation of endometrial cancer GWAS risk loci reveals potentially causal variants and supports a role for NF1 and SKAP1 as susceptibility genes.

NF1 SKAP1

4.59e-06275236908940
Pubmed

Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.

C4A C4B

4.59e-06275228873507
Pubmed

The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4.

C4A C4B

4.59e-0627526609966
Pubmed

Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes.

C4A C4B

4.59e-0627522900855
Pubmed

Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.

C4A C4B

4.59e-062752276882
Pubmed

Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.

C4A C4B

4.59e-0627526832377
Pubmed

Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.

C4A C4B

4.59e-0627523794341
Pubmed

Complement and c4 null alleles in severe chronic adult periodontitis.

C4A C4B

4.59e-06275217257223
Pubmed

Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events.

C4A C4B

4.59e-0627522272665
Pubmed

Multiple C4/Slp genes distinguished by expression after transfection.

C4A C4B

4.59e-0627523023818
Pubmed

Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.

C4A C4B

4.59e-06275222785613
Pubmed

A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells.

TPTE TPTE2

4.59e-06275222164291
Pubmed

Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.

C4A C4B

4.59e-06275232691186
Pubmed

Genetic deficiency in complement component 4b does not alter radiation-induced lung disease in mice.

C4A C4B

4.59e-06275223259761
Pubmed

Lack of evidence of a specific role for C4A gene deficiency in determining disease susceptibility among C4-deficient patients with systemic lupus erythematosus (SLE).

C4A C4B

4.59e-06275211168010
GeneFamilyC2 tensin-type domain containing|PTEN protein phosphatases|Phosphoinositide phosphatases

TPTE TPTE2

6.03e-055452902
GeneFamilyNuclear factors of activated T-cells

NFATC2 NFAT5

6.03e-055452665
GeneFamilyDNAJ (HSP40) heat shock proteins|C2 tensin-type domain containing

TPTE TPTE2

1.68e-048452837
GeneFamilyTransmembrane channel likes

TMC7 TMC8

1.68e-0484521135
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

C4A C4B

2.16e-0494521234
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PRKD3 RASA3 ARHGEF7 SKAP1

1.69e-03206454682
GeneFamilyComplement system|Sushi domain containing

C4A C4B

3.62e-0336452492
GeneFamilyGlycosyltransferase family 6|Blood group antigens

C4A C4B

3.82e-0337452454
GeneFamilyFibronectin type III domain containing

PTPRF FLRT3 OSMR

7.35e-03160453555
GeneFamilyUbiquitin specific peptidases

USP10 USP11

8.57e-0356452366
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRRC63 NFATC2 SKAP1 SETBP1 TENM1 PTPN22

3.14e-07161756d72c572613f8eff3251cb7b1e9dcc76d193b2f21
ToppCellCOVID-19-lung-CD4+_Treg|COVID-19 / Disease (COVID-19 only), tissue and cell type

ANK3 NFATC2 RASA3 SKAP1 TMC8 PTPN22

8.54e-071917565a4ad5ae5c2dbfb225158cb598ef649c26a48350
ToppCellCOVID-19-T_cells-CD4+_T_cells|COVID-19 / group, cell type (main and fine annotations)

ANK3 NFATC2 RASA3 SKAP1 TMC8 PTPN22

8.54e-071917560646cca78e24aeb6baa9934d3c439b797c567997
ToppCellCOVID-19-T_cells|COVID-19 / group, cell type (main and fine annotations)

ANK3 NFATC2 RASA3 SKAP1 TMC8 PTPN22

8.54e-071917567f64add931b64b8d35836fa6bee9ebab593844d3
ToppCellChildren_(3_yrs)-Immune-natural_killer_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

NFATC2 RASA3 SKAP1 TMC8 TENM1 PTPN22

9.08e-071937561cb666375bc4e1b11a146d20896c9b5ae6fd0887
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NFATC2 SKAP1 SETBP1 TMC8 TENM1 PTPN22

9.93e-07196756c9fb81a0578db6d278b8582d7b3add6c407e6dcf
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_GZMK+|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFATC2 RASA3 SKAP1 TMC8 TENM1 PTPN22

1.12e-06200756510d84bf7a4621b079e5a7330d25e04508c84a49
ToppCellBronchial-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFATC2 RASA3 SKAP1 SETBP1 TMC8 PTPN22

1.12e-06200756bfbd2ccf4b28901aad63d70a382a8247e4458ba6
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_PP_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CALR3 ADAM7 TENM1 C4A MTFP1

8.50e-0616475574a35ba77e93d864161beb6b133d654473981bb7
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Lymphocytic-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRF ANK3 NOC2L SKAP1 PTPN22

1.13e-051747556987fe7959afce347282f632abc16d800ccab7c4
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BPIFC USP11 IFI44 KCTD1 ANKS3

1.13e-05174755a9f34d1237f335d27c5560ff514368f4709f9144
ToppCellChildren_(3_yrs)-Immune-natural_killer_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.13e-0517475533d6b81f31bfcb9c4b30206d88e20b9a94fba4a2
ToppCellAdult-Immune-natural_killer_cell-D175|Adult / Lineage, Cell type, age group and donor

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.33e-05180755fc59e28f39e7d4fb1bcc7205202cf39224b70d7b
ToppCellAdult-Immune-natural_killer_cell-D231|Adult / Lineage, Cell type, age group and donor

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.41e-05182755dbf47bf4754d8ec3bc3ab1d5be7a6c47a7afbf43
ToppCellControl-T_cells-CD8+_T_cells|Control / group, cell type (main and fine annotations)

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.52e-0518575502ab64c0166c0646d1d4c6ed110ef0b75a1096d0
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.52e-0518575545890fa81c65a48f4fdec164a4c8d0e2831243c0
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.52e-05185755585bcfdff85bf43f5aa4cd1b39f7dcf1c78d7b02
ToppCellControl-T_cells-NK_cells|Control / group, cell type (main and fine annotations)

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.52e-05185755755c0998c729f462399f1d5e88adf4bfae31be30
ToppCellControl-T_cells|Control / group, cell type (main and fine annotations)

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.60e-05187755f4e8e0eba58da89b56587667555a5d4754e108c7
ToppCellCOVID-19-T_cells-CD8+_T_cells|COVID-19 / group, cell type (main and fine annotations)

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.69e-051897552c018d6120f65f0b2704b483bc9da1c0984872e3
ToppCellCOVID-19-T_cells-NK_cells|COVID-19 / group, cell type (main and fine annotations)

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.69e-05189755b699152dfbb8cd8ed724e1e5a51838f29b681b62
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.73e-051907554a75457652d85874d5c6a41648f8003572008b15
ToppCellFetal_29-31_weeks-Immune-T_lymphocyte-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RASA3 SKAP1 TMC8 TENM1 PTPN22

1.73e-051907552a8de1cf27a9ebc3825cf9e7a489ecd064dfc7f9
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.73e-05190755d153a0bdedcd6865e6ee19575234a78b5d859ff1
ToppCellCOVID-19-kidney-NK|kidney / Disease (COVID-19 only), tissue and cell type

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.73e-05190755e3ca3c9fb9e27670a5dd128dd6564ff98a57159e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK-T_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.73e-0519075507ea0578ca0561077557203ae660530f53fc4067
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.73e-05190755b772a5d281fe016f259ddda80d6f33d949dcac2b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK-T_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.73e-051907555b4b3eed7aa798bb7e3c5e968c8dc4144e377a5f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.73e-05190755cda6173634531240e0bab8766231a150ff8d0129
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.77e-0519175596a7179a845d3daa046ed71fa45c51255f130a7f
ToppCellCOVID-19-kidney-Proliferating_T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

BRIP1 NFATC2 SKAP1 GTSE1 PTPN22

1.77e-05191755bae388e0e9447d576e68465d73d8313ef6925ffa
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-T_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.77e-051917551a2d5fec2bea96da2154b0aed252f1bb35102f6e
ToppCellAdult-Immune-natural_killer_cell|Adult / Lineage, Cell type, age group and donor

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.77e-05191755758ec27e47d7662a5175305e98a1506c6859dbf7
ToppCellCOVID-19-lung-CD8+_T_cells|COVID-19 / Disease (COVID-19 only), tissue and cell type

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.77e-05191755543f8ae07cc2e6950c888115a5ca9445e3c0f618
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-T_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.77e-05191755326b4541069efedc8ab409f85bb11f77346dda90
ToppCellChildren_(3_yrs)-Immune-natural_killer_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

NFATC2 RASA3 SKAP1 TMC8 TENM1

1.77e-051917556345c1aa0fd2f9f2154a44f9393bf7c72bb1f44e
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANK3 NFATC2 SKAP1 TENM1 TMEM63A

1.77e-051917554a29b7d5cd10e9077699d3aa76e3db6c4d5a0cf6
ToppCellCOVID-19-lung-CD4+_Treg|lung / Disease (COVID-19 only), tissue and cell type

ANK3 NFATC2 SKAP1 TMC8 PTPN22

1.77e-0519175573ea3078c1f55cd47e4d99e77b3ce4ff17549d49
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.82e-051927558f0d37d204958aaf77214a6c75bef2bf5498f11c
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.82e-051927558f7e0ddf3855199b0aa63b633dc2948f03607933
ToppCellImmune-natural_killer_cell|World / Lineage, Cell type, age group and donor

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.82e-0519275568121a6ef4115a93d87aad8802ef9b27d793d8c0
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.87e-0519375512f1333f11e6c262954ad7912d8fd2962ab06d25
ToppCellCF-Lymphoid|CF / Disease state, Lineage and Cell class

NFATC2 SKAP1 SETBP1 TMC8 PTPN22

1.87e-0519375511de07d13a7da223990b56fa89ba7fc1c3dd0122
ToppCellCOVID-19-lung-NK/NKT|COVID-19 / Disease (COVID-19 only), tissue and cell type

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.87e-05193755c24b44fcc92fff42ebba6f1aff91c7aaea179e56
ToppCellCOVID-19-lung-NK_cells|COVID-19 / Disease (COVID-19 only), tissue and cell type

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.91e-051947554c92f18e0a34fb50630d4b260eaf179202508b6d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-T_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.91e-05194755633fe72cc8a489abde12428e326478409ca03263
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-T_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.91e-0519475587a86df0b542f287b0b20f4a4b1a37002271671d
ToppCellCOVID-19-lung-CD4+_T_cells_metabolically_active|lung / Disease (COVID-19 only), tissue and cell type

ANK3 NFATC2 SKAP1 TMC8 PTPN22

1.91e-051947552a144a1c2d537c8a59aa419206ddd96c23f0aeab
ToppCellCOVID-19-kidney-Proliferating_T_cell|kidney / Disease (COVID-19 only), tissue and cell type

BRIP1 NFATC2 GTSE1 TMC8 PTPN22

1.96e-051957557e05e56f8d0a7a052830c7db12b10dace7d10760
ToppCellCOVID-19-lung-NK_cells|lung / Disease (COVID-19 only), tissue and cell type

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.96e-051957553b716ec7acc9a37af6bf40e711a539ce58d74aa4
ToppCellCOVID-19-lung-NK/NKT|lung / Disease (COVID-19 only), tissue and cell type

NFATC2 RASA3 SKAP1 TMC8 PTPN22

1.96e-051957553ab941a369e3815f338890b116dc77aefa054098
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NFATC2 SKAP1 SETBP1 TENM1 PTPN22

1.96e-0519575514a6466524c22920daa622fbc710daf1defb46c3
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NFATC2 RASA3 SKAP1 TENM1 PTPN22

2.06e-051977550e93800d5df652a9c691c66a3f75a2e8979aed8e
ToppCellCOVID-19-kidney-T-cells-1|kidney / Disease (COVID-19 only), tissue and cell type

NFATC2 RASA3 SKAP1 TMC8 PTPN22

2.06e-051977559bb7faf4ef63cca4d06c60e6c05a9616fdb6b98e
ToppCellTracheal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_GZMK+|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFATC2 RASA3 SKAP1 TMC8 PTPN22

2.16e-0519975509e0b45529fa9d5fc86da1747b3fb3a238a09aa6
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RASA3 SKAP1 SETBP1 TMC8 PTPN22

2.16e-051997557d69785717073491b5fb81bf24db0175f86cd0b0
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_CTL|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFATC2 RASA3 SKAP1 TMC8 PTPN22

2.16e-0519975554b64f01e7a73a88bd92b6d4e73cccde60396b2d
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_CTL|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFATC2 RASA3 SKAP1 TMC8 PTPN22

2.16e-05199755eb188b0b457136b6ee485d3b3052baa30d9c0002
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFATC2 RASA3 SKAP1 TMC8 PTPN22

2.21e-05200755dfdfad881c114e1bc9a64b411e1b00fb37cc859b
ToppCellBronchial-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFATC2 RASA3 SKAP1 TMC8 PTPN22

2.21e-052007557eed3d932018d6a87ce37d013883b371db55caeb
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-NK|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFATC2 RASA3 SKAP1 TMC8 PTPN22

2.21e-052007557d90fcb5dfc4c9d562c93b0f9293ed12b5f4f404
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-NK-ILC|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFATC2 RASA3 SKAP1 TMC8 PTPN22

2.21e-05200755d2422aaf807010194994db97142b9fd2e807312d
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD3|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFATC2 RASA3 SKAP1 TMC8 PTPN22

2.21e-052007556b34f2b85d4f83c1270ee151f602cba6f42042ba
ToppCellBronchial-NucSeq-Immune_Lymphocytic-NK-ILC|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFATC2 RASA3 SKAP1 TMC8 PTPN22

2.21e-0520075556d738ff019682af7f1f8cbe7b262a75dc8596d5
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFATC2 RASA3 SKAP1 TMC8 PTPN22

2.21e-05200755c6c2b39359c65c9444987d02d1c899dff2ad1366
ToppCellBronchial-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-NK|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFATC2 RASA3 SKAP1 TMC8 PTPN22

2.21e-052007550f8e2fed93cc103b20a825d8d3e83787c5c015cc
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFATC2 RASA3 SKAP1 TMC8 PTPN22

2.21e-0520075566fb892bda1d29e67a65717e85f2ec221f520b2a
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD3-NKT|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFATC2 RASA3 SKAP1 TMC8 PTPN22

2.21e-05200755b2c5618aa1ac19423996336795dadb39ea57cda7
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T-T_CD4|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFATC2 RASA3 SKAP1 TMC8 PTPN22

2.21e-052007559de4d6ebb7e9bee5d811519eb05913ef30f70786
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD4|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFATC2 RASA3 SKAP1 TMC8 PTPN22

2.21e-05200755f7a9d8b99de19e9842422bada348d940e0863645
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFATC2 RASA3 SKAP1 TMC8 PTPN22

2.21e-052007551d2ee63010b7b8b38bea7d3b30eebfbcdd18b967
ToppCellLPS-IL1RA-Lymphocytic_NKT-T_cells-iNKT-MAIT|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NFATC2 SKAP1 TMC8 PTPN22

7.76e-0513475492981dc68c1b3cdc53f9cf83386c47f0c6c98ae7
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NFATC2 TPTE2 SKAP1 TENM1

1.17e-041497543378d0fe79de6d7879fd48717ded5027593c785f
ToppCellPND07-28-samps-Mesenchymal-Pericyte-pericyte_F|PND07-28-samps / Age Group, Lineage, Cell class and subclass

GPR21 TMC7 HYKK TMEM178A

1.20e-041507542d0d6dc07dcfe28e3d7694c52d15d17dae2fd47b
ToppCellPND07-28-samps-Mesenchymal-Pericyte|PND07-28-samps / Age Group, Lineage, Cell class and subclass

GPR21 TMC7 HYKK TMEM178A

1.20e-041507545b111ec11a642d63fafa7e1422e36f81a2776531
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CNGB3 GPR52 NFAT5 TMEM63A

1.36e-04155754441fcb6d05364fc6f4973f0b973f1a80b573ce1f
ToppCellCOVID-19_Moderate-multiplets|World / disease group, cell group and cell class

NFATC2 TMC8 IFI44 ARHGAP20

1.40e-04156754afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SKAP1 RRP12 TMC8 CA13

1.50e-04159754f7bccfeffa737f151417bf52ea45111b0957bce9
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

NFATC2 SKAP1 TENM1 PTPN22

1.54e-041607548e2b51d7b42e0b6e62641efdbbc73d31561d6a3e
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PRKD3 SKAP1 TENM1 PTPN22

1.54e-0416075450d4f867d021abcfeb49e6812bcfd5bb57466a31
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PRKD3 SKAP1 TENM1 PTPN22

1.54e-041607540f15f895f11dcabb73df79b26bfc4947f38435a7
ToppCell10x3'2.3-week_12-13-Hematopoietic-HSC/MPP_and_pro-LMPP|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ANK3 ARHGEF7 IFI44 TMEM63A

1.54e-0416075460fa1c717410aad7e8647703cb416cd7617cac29
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PRKD3 SKAP1 TENM1 PTPN22

1.54e-041607547d004bfe42707605b3851cb2319126acda4d4802
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B1|367C / Donor, Lineage, Cell class and subclass (all cells)

NFATC2 SKAP1 UTP20 UBE3C

1.58e-04161754f470b662566131dfe69a2fd01186ac8491196396
ToppCell5'-Adult-Appendix-Hematopoietic-T_cells-Activated_CD8_T|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRRC63 TMC8 GPR52 PTPN22

1.69e-0416475424fdea5113d92b96f56b06dd2449910a3c785e69
ToppCellE16.5-Endothelial-Endothelial_lymphatic|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RASIP1 TMC7 SKAP1 TMEM63A

1.81e-04167754b93103a868fba63a8910bffb690a6242b9252833
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RASIP1 TMC7 SKAP1 TMEM63A

1.81e-04167754fcd583b1efd0ac883379982ea8e6c54f2c0be268
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RASIP1 TMC7 SKAP1 TMEM63A

1.81e-04167754f6bc63138b7239211fa5f27a8dc799b6e022c0f8
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RASIP1 TMC7 SKAP1 TMEM63A

1.81e-0416775426cd8ee5e826e71eaf58d10a906543a6932fb3f9
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5+_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR21 UTP20 ATIC KCTD1

1.85e-04168754d69452e2cfeb74023b5cf3d09064d7dcad0008ec
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NFATC2 SKAP1 SETBP1 TMC8

1.94e-0417075432917888c3f1d54302675c1d4de1fd3b7c79af5f
ToppCellLPS-IL1RA-Lymphocytic_NKT-T_cells-T-cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NFATC2 SKAP1 TMC8 PTPN22

1.98e-04171754539ea88acc6f948efdeae8b69e5c5ffaee29f1d9
ToppCellnormal_Pleural_Fluid-T/NK_cells-Cytotoxic_CD8+_T|normal_Pleural_Fluid / Location, Cell class and cell subclass

SKAP1 P4HA3 GPR52 PTPN22

1.98e-041717546be81c20f4e962b414afcedfe478dd59c510d1e1
ToppCellLPS-IL1RA-Lymphocytic_NKT-T_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NFATC2 SKAP1 TMC8 PTPN22

2.03e-041727540fc692be845d4225ff8b63bf9195724fc8510c2c
ToppCellnormal_Pleural_Fluid-T/NK_cells-Cytotoxic_CD8+_T|T/NK_cells / Location, Cell class and cell subclass

P4HA3 GPR52 PTPN22 ARHGAP20

2.07e-041737541e8a43ff32eab95857c794e0bf4f0b0dba155b4a
ToppCelldroplet-Mammary_Gland-nan-3m-Endothelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASIP1 ARHGEF7 IFI44 NFAT5

2.07e-04173754fbc8ed566ea36c39c258dd6b3823c82f5d6eb17f
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BRIP1 SKAP1 SPO11 PTPN22

2.12e-041747546b362b8a934a4fe6a1dd867b7c448cb3fb3ffd6a
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRRC63 NFATC2 SKAP1 SETBP1

2.12e-041747549bb8159a62640756d18ecbade3bf32bcbb7dd590
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRRC63 NFATC2 SKAP1 SETBP1

2.12e-04174754e70cc623a3a6aceec813ed852fec0c4240561133
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRRC63 NFATC2 SKAP1 SETBP1

2.12e-04174754b6725086fe5a2b057c7c495ec63c970ac52c2580
DrugThalidomide [50-35-1]; Down 200; 15.4uM; PC3; HT_HG-U133A

CEP104 HSP90B1 BRIP1 ARHGEF7 BTD IFI44 NFAT5 TMEM63A

2.80e-071977582095_DN
Drug2-aminothiophenol

C4A C4B

3.21e-053752ctd:C005464
DrugCP-319743 [172078-87-4]; Up 200; 10uM; MCF7; HT_HG-U133A

NF1 ERP44 ADAM7 RRP12 PTPN22 GRM1

4.01e-051917567486_UP
DrugCitalopram hydrobromide [59729-32-7]; Down 200; 1uM; MCF7; HT_HG-U133A

NF1 TMC7 RASA3 PDK3 NFAT5 TMEM63A

4.38e-051947563903_DN
DrugIopamidol [60166-93-0]; Up 200; 5.2uM; MCF7; HT_HG-U133A

CEP104 HSP90B1 TMC7 RASA3 RRP12 TMEM63A

4.38e-051947567189_UP
DrugHeptaminol hydrochloride [543-15-7]; Down 200; 22uM; MCF7; HT_HG-U133A

NF1 BTD RRP12 FLRT3 GRM1 TMEM63A

4.63e-051967566015_DN
DrugTetracycline hydrochloride [64-75-5]; Up 200; 8.4uM; MCF7; HT_HG-U133A

NF1 BTD ADAM7 CNGB3 OSMR TMEM63A

4.77e-051977566233_UP
DrugProbucol [23288-49-5]; Down 200; 7.8uM; PC3; HT_HG-U133A

CEP104 NF1 PDK3 BTD GRM1 TMEM63A

4.77e-051977564666_DN
DrugMyricetin [529-44-2]; Down 200; 12.6uM; MCF7; HT_HG-U133A

CEP104 ERP44 ANK3 BTD NFAT5 TMEM63A

4.77e-051977563270_DN
DrugPramoxine hydrochloride [637-58-1]; Down 200; 12.2uM; MCF7; HT_HG-U133A

NF1 RASA3 CNGB3 OSMR NFAT5 TMEM63A

4.77e-051977563894_DN
DrugDyclonine hydrochloride [536-43-6]; Up 200; 12.2uM; PC3; HT_HG-U133A

CEP104 HSP90B1 PTPRF ARHGEF7 BTD TMEM63A

4.90e-051987567261_UP
DrugLevamisole hydrochloride [16595-80-5]; Down 200; 16.6uM; MCF7; HT_HG-U133A

PRKD3 NF1 RRP12 OSMR PIGZ TMEM63A

4.90e-051987567450_DN
DrugAG-012559 [369370-06-9]; Down 200; 10uM; MCF7; HT_HG-U133A

PRKD3 NF1 PTPN22 FLRT3 OSMR TMEM63A

4.90e-051987566889_DN
DrugNorethynodrel [68-23-5]; Down 200; 13.4uM; MCF7; HT_HG-U133A

PRKD3 NF1 ARHGEF7 RRP12 OSMR TMEM63A

5.04e-051997567471_DN
DrugIsoetharine mesylate salt [7279-75-6]; Up 200; 12uM; MCF7; HT_HG-U133A

HSP90B1 NF1 TMC7 RRP12 FLRT3 TMEM63A

5.19e-052007567170_UP
DiseaseDrugs used in diabetes use measurement

NF1 NFATC2 CDC123 PTPN22 UBE3C NFAT5

4.80e-05255756EFO_0009924
DiseaseHWESASXX measurement

DPP10 CNGB3

1.33e-047752EFO_0021147
DiseaseGraves' disease (is_implicated_in)

PTPN22 C4A C4B

1.35e-0439753DOID:12361 (is_implicated_in)
Diseasesystemic lupus erythematosus (implicated_via_orthology)

ATG5 C4A C4B

1.81e-0443753DOID:9074 (implicated_via_orthology)
Diseaserheumatoid arthritis, systemic lupus erythematosus

ATG5 PTPN22

2.83e-0410752EFO_0000685, MONDO_0007915
Diseasesystemic lupus erythematosus (is_implicated_in)

PTPN22 C4A C4B

5.36e-0462753DOID:9074 (is_implicated_in)
DiseaseLupus Erythematosus, Systemic

PTPN22 C4A C4B

7.96e-0471753C0024141
Diseaserenal fibrosis (implicated_via_orthology)

GPR21 GPR52

8.46e-0417752DOID:0050855 (implicated_via_orthology)
DiseaseJuvenile Myelomonocytic Leukemia

NF1 SETBP1

1.06e-0319752C0349639
Diseasevitiligo (is_implicated_in)

PTPN22 C4A

1.30e-0321752DOID:12306 (is_implicated_in)
Diseaseresponse to mTOR inhibitor

USP10 BRIP1

1.84e-0325752EFO_0005417

Protein segments in the cluster

PeptideGeneStartEntry
DYLLPEEYTSTLKVL

ADCK1

111

Q86TW2
LYTLILRPDLSYDVK

CALR3

171

Q96L12
IYLAPTLAASRYLDK

C4B

1016

P0C0L5
LPYYSTSIIKDLLPD

ADAM7

311

Q9H2U9
IRTITYDSLSKIPYL

FLRT3

116

Q9NZU0
YSKELQTVLSTYLRP

ARHGEF7

286

Q14155
YDSSLRPLSIKYDPS

CA13

41

Q8N1Q1
YLLLPRVSYLTLVTD

ATG5

36

Q9H1Y0
SSYLDLLTLSYKPGR

C7orf33

131

Q8WU49
YYQPDIKSSSLRLTS

DPP10

201

Q8N608
YLTKTLYSTLPALLD

RASIP1

706

Q5U651
LSALYRLESKEPFLS

RALYL

106

Q86SE5
SLTETELTKPNYLYL

OSMR

826

Q99650
SSDYYSPLRDLLLKS

RASA3

296

Q14644
KDILPYDYSRVELSL

PTPN22

61

Q9Y2R2
AITDLYSPKRLFSLT

P4HA3

166

Q7Z4N8
LYQRSKSLSPSLLGY

NFATC2

751

Q13469
YLSSTPQRLKLLDAY

DAD1

16

P61803
TSLKPTEILYLTVAY

MTMR14

356

Q8NCE2
YTSSLATLTKYPESR

KCTD1

41

Q719H9
YYKEIPLSEILRISS

PRKD3

456

O94806
DFLLDSSLRKLYPTV

MTFP1

146

Q9UDX5
SPELYTTYFVTKTLL

MT-ND1

251

P03886
FLTELAPLSIYSSRK

LRRC63

521

Q05C16
SALLPSIVYYSTLLE

TMEM63A

476

O94886
SVDRYLAITKPLSYN

GPR52

136

Q9Y2T5
KLTREEGTPLTLYYS

NOC2L

606

Q9Y3T9
ESPKSLYSRESVYDL

NFAT5

16

O94916
LYSRESVYDLLPKEL

NFAT5

21

O94916
SLKRETYYLSDSPLL

GTSE1

141

Q9NYZ3
VTSLKYSTSPYLLEA

BRIP1

911

Q9BX63
KSPRTYSEITLYLII

PCDHAC2

696

Q9Y5I4
ATLRSGYLLPDTKAY

HSP90B1

721

P14625
TYARKSDYISPLDDL

CEP104

186

O60308
SEIKSYLVRLLTYLP

HYKK

116

A2RU49
LRKSLLSALRTYEPY

IFI44

166

Q8TCB0
LLYALKSSPRLSLLY

BFAR

271

Q9NZS9
KSSPRLSLLYLYLFD

BFAR

276

Q9NZS9
YTLLDYSLISSPEIT

BPIFC

226

Q8NFQ6
YLSYRLPKDFVDLST

CDC123

301

O75794
LAYSKAYPRLLISSL

FCGBP

46

Q9Y6R7
SYILLSYLSEKTTLI

HEATR4

616

Q86WZ0
LLYERPTLSKELYAL

BTD

426

P43251
ASLALRKRYSYLTEP

ANK3

1461

Q12955
RYKSYSPSDLVELVA

ELP3

336

Q9H9T3
SFQKLAPSEYRYTLL

ERP44

386

Q9BS26
SLYRSPEKYEDLSSS

ANKS3

231

Q6ZW76
PSLLYLEVSTLVSKY

EXOC3

671

O60645
AEYLYSTPEQLSKRL

GTDC1

401

Q4AE62
TLYKYFLRVVPSDTL

GRM1

196

Q13255
DRYIAITKPLTYNTL

GPR21

126

Q99679
IYLAPTLAASRYLDK

C4A

1016

P0C0L4
SYTLEDLKPDTLYRF

PTPRF

566

P10586
PSIDYLDSKLSYLRE

ARHGAP20

706

Q9P2F6
SNPRALYLESKLYEL

UTP20

926

O75691
SISYDLNRLPKLIYS

TMEM178A

231

Q8NBL3
SLSAPLTSYKVIYVL

LARS1

361

Q9P2J5
LSYLSSRTPGYKTLL

TENM1

1026

Q9UKZ4
VTLTLTYLFIKEYSP

SGMS2

231

Q8NHU3
IYLKALSSESFERLP

PDK3

356

Q15120
EAAISKLYSTIRPYL

RRP12

766

Q5JTH9
LPNSIDSYTDRLYLL

CNGB3

206

Q9NQW8
RTDYKTLPSEYSILA

C11orf40

176

Q8WZ69
TDSKLYIPLEYRSIS

TPTE

116

P56180
SSVYSIRLAYLLSPL

TMC8

196

Q8IU68
PLKTSLELITRYFLD

MINDY4

66

Q4G0A6
LSSDYLSRVYLPNKL

SPO11

376

Q9Y5K1
PTDLETRSYKYLLLS

NF1

481

P21359
IATSKATEYYRTPLL

UBE2U

186

Q5VVX9
SLLSSPRSYLLLLYF

PIGZ

361

Q86VD9
DLYKTLTPISAAYAR

ATIC

291

P31939
PTYIYRLLTVNKSSL

USP10

501

Q14694
IFTDSKLYIPLEYRS

TPTE2

96

Q6XPS3
YDPLLYLRRTSDLKS

SETBP1

1001

Q9Y6X0
YKLYQLEEPLSSILD

USP11

551

P51784
SFLLKDLSSLTIPYE

SKAP1

206

Q86WV1
TYDLPLAYLLSTIAS

TMC7

261

Q7Z402
LYLLINSKLPSSIEY

UBE3C

211

Q15386